Strain Name:

C3H/HeJ-agil/J

Stock Number:

004780

Availability:

Repository- Live

Description

Strain Information

Former Names C3H/HeJ-agil    (Changed: 15-DEC-04 )
Type Coisogenic; Mutant Strain; Spontaneous Mutation;
Additional information on Genetically Engineered Mutant Mice.
Specieslaboratory mouse
H2 Haplotypek
GenerationN2F2 (07-DEC-07)

Appearance
agouti, unaffected
Related Genotype: A/A agil/+ or A/A +/?

Important Note
This strain is homozygous for the retinal degeneration allele Pde6brd1.

Description
Mice homozygous for this recessive mutation are recognized by 15 days of age by their shaky, unsteady, wobbly gait. Mutants die around three weeks of age. The agitans-like mutation maps to Chromosome 14 between D14Mit39 and D14Mit115 which are near the neurological mouse mutation agitans (ag). The agitans mutants exhibit a similar phenotype.

Development
The agil mutation arose spontaneously in 1999 at The Jackson Laboratory on the C3H/HeJ background when that inbred was at F233. It has been maintained by sibling breeding.

Control Information

  Control
   +/? untyped from the colony
 
  Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of agil
008657   AKR/J-agil2J/J
View Strains carrying other alleles of agil     (1 strain)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms
      assigned by genotype

agil/agil

        C3H/HeJ
  • lethality-postnatal
  • postnatal lethality (MGI Ref ID J:84746)
    • homozygotes die by 3 weeks of age
  • behavior/neurological phenotype
  • ataxia (MGI Ref ID J:84746)
    • mice exhibit an unsteady, shaky, wobbly gait
  • growth/size phenotype
  • postnatal growth retardation (MGI Ref ID J:84746)
    • by 15 days of age, homozygous mutant mice are smaller than their littermates
  • nervous system phenotype
  • abnormal myelination (MGI Ref ID J:84746)
    • pathological screen of ten mutants and two controls, all at about 3 weeks of age, had slightly less deeply staining myelin in spinal cord stained with luxal fast blue
  • abnormal spinal cord morphology (MGI Ref ID J:84746)
    • three of ten mutants had a few scatttered dystrophic axons and degenerating myelin sheaths (myelin figures) in spinal cord white matter; these changes are consistant with early degeneration of spinal cord white matter
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

agil related

Developmental Biology Research
Neurodevelopmental Defects
Postnatal Mortality

Neurobiology Research
Ataxia (Movement) Defects
Myelination Defects

Genes & Alleles

Gene & Allele Information

Allele Symbol agil
Allele Name agitans-like
Allele Type Spontaneous
Strain of OriginC3H/HeJ

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Optimizing PCR Protocols

References

References

Selected Reference(s)

Harris BS; Ward-Bailey P; Bronson RT; Donahue LR. 2003. Agitans-like (agil), a suspected remutation to agitans (ag) on mouse Chromosome 14. Mouse Mutant Resources Web Site, The Jackson Laboratory, Bar Harbor, Maine (http://www.jax.org/mmr) MGI Direct Data Submission :.  [MGI Ref ID J:84746]

Original article from The Mouse Mutant Resource

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           A1

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations View International pricing
Weeks of AgePrice*GenderGenotypes Provided
Individual Mouse Price $127.90Female or MaleHeterozygous for agil
Pairs /Price*Pair Genotype
$255.80Heterozygous for agil x Heterozygous for agil
*Price(s) in US dollars ($)

Additional Supply Details

Supply Notes

Pricing for International shipping destinations View USA Canada and Mexico pricing
Weeks of AgePrice*GenderGenotypes Provided
Individual Mouse Price $166.30Female or MaleHeterozygous for agil
Pairs /Price*Pair Genotype
$332.60Heterozygous for agil x Heterozygous for agil
*Price(s) in US dollars ($)

Additional Supply Details

Supply Notes

Supply Details

Standard SupplyRepository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.
Supply Notes
Important NoteThis strain is homozygous for the retinal degeneration allele Pde6brd1.

Control Information

  Control
   +/? untyped from the colony
 
  Considerations for Choosing Controls
  USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
  International - Control Pricing Information for Genetically Engineered Mutant Strains.

General Terms and Conditions


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