Description

Strain Information

Former Names C3H/HeJ-agil/J    (Changed: 22-JUN-09 ) C3H/HeJ-agil    (Changed: 15-DEC-04 ) Type Coisogenic; Mutant Strain; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse H2 Haplotype k Generation N2F8 (12-NOV-10) Generation Definitions

Appearance
agouti, unaffected
Related Genotype: A/A agil/+ or A/A +/?

Important Note
This strain is homozygous for the retinal degeneration allele Pde6b^rd1.

Description
Mice homozygous for this recessive mutation are recognized by 15 days of age by their shaky, unsteady, wobbly gait. Mutants die around three weeks of age. The agitans-like mutation maps to Chromosome 14 between D14Mit39 and D14Mit115 which are near the neurological mouse mutation agitans (ag). The agitans mutants exhibit a similar phenotype.

Development
The agil mutation arose spontaneously in 1999 at The Jackson Laboratory on the C3H/HeJ background when that inbred was at F233. It has been maintained by sibling breeding.

Control Information

	Control
	+/? untyped from the colony
Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of agil

008657	AKR/J-agil2J/J
014084	CBA/J-agil3J/GrsrJ

View Strains carrying other alleles of agil     (2 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI

      assigned by genotype

agil/agil

        C3H/HeJ

• mortality/aging
• complete postnatal lethality
  • homozygotes die by 3 weeks of age   (MGI Ref ID J:84746)
• behavior/neurological phenotype
• ataxia
  • mice exhibit an unsteady, shaky, wobbly gait   (MGI Ref ID J:84746)
• growth/size phenotype
• postnatal growth retardation
  • by 15 days of age, homozygous mutant mice are smaller than their littermates   (MGI Ref ID J:84746)
• nervous system phenotype
• abnormal myelination
  • pathological screen of ten mutants and two controls, all at about 3 weeks of age, had slightly less deeply staining myelin in spinal cord stained with luxal fast blue   (MGI Ref ID J:84746)
• abnormal spinal cord white matter morphology
  • three of ten mutants had a few scatttered dystrophic axons and degenerating myelin sheaths (myelin figures) in spinal cord white matter; these changes are consistant with early degeneration of spinal cord white matter   (MGI Ref ID J:84746)
• axonal dystrophy
  • three of ten mutants had a few scatttered dystrophic axons in spinal cord white matter   (MGI Ref ID J:84746)

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

agil related

Developmental Biology Research
Neurodevelopmental Defects
Postnatal Lethality

Neurobiology Research
Ataxia (Movement) Defects
Myelination Defects

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol		agil
Allele Name		agitans-like
Allele Type		Spontaneous
Strain of Origin		C3H/HeJ
Gene Symbol and Name		agil, agitans-like
Chromosome		14

Genotyping

Genotyping Information

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Harris BS; Ward-Bailey P; Bronson RT; Donahue LR. 2003. Agitans-like (agil), a suspected remutation to agitans (ag) on mouse Chromosome 14. Mouse Mutant Resources Web Site, The Jackson Laboratory, Bar Harbor, Maine MGI Direct Data Submission :.  [MGI Ref ID J:84746]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           A1

Purchasing information

Pricing, Supply Level & Notes, Controls

General Supply Notes

• This strain is included in the Mouse Mutant Resource collection.
• Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

	Control
	+/? untyped from the colony
Considerations for Choosing Controls
Control Pricing Information for Genetically Engineered Mutant Strains.

Important Note

This strain is homozygous for the retinal degeneration allele Pde6b^rd1.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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