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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Former Names C3H/HeJ-agil (Changed: 15-DEC-04 ) Type Coisogenic; Mutant Strain; Spontaneous Mutation; Additional information on Genetically Engineered Mutant Mice. Species laboratory mouse H2 Haplotype k Generation N2F2 (07-DEC-07) Appearance
agouti, unaffected
Related Genotype: A/A agil/+ or A/A +/?Important Note
This strain is homozygous for the retinal degeneration allele Pde6brd1.Description
Mice homozygous for this recessive mutation are recognized by 15 days of age by their shaky, unsteady, wobbly gait. Mutants die around three weeks of age. The agitans-like mutation maps to Chromosome 14 between D14Mit39 and D14Mit115 which are near the neurological mouse mutation agitans (ag). The agitans mutants exhibit a similar phenotype.Development
The agil mutation arose spontaneously in 1999 at The Jackson Laboratory on the C3H/HeJ background when that inbred was at F233. It has been maintained by sibling breeding.
Control Information
| Control | ||
|---|---|---|
| +/? untyped from the colony | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of agil
008657 AKR/J-agil2J/J View Strains carrying other alleles of agil (1 strain)
Phenotype
Phenotype Information
assigned by genotype
agil/agil
C3H/HeJ
- lethality-postnatal
- postnatal lethality (MGI Ref ID J:84746)
- homozygotes die by 3 weeks of age
- behavior/neurological phenotype
- ataxia (MGI Ref ID J:84746)
- mice exhibit an unsteady, shaky, wobbly gait
- growth/size phenotype
- postnatal growth retardation (MGI Ref ID J:84746)
- by 15 days of age, homozygous mutant mice are smaller than their littermates
- nervous system phenotype
- abnormal myelination (MGI Ref ID J:84746)
- pathological screen of ten mutants and two controls, all at about 3 weeks of age, had slightly less deeply staining myelin in spinal cord stained with luxal fast blue
- abnormal spinal cord morphology (MGI Ref ID J:84746)
- three of ten mutants had a few scatttered dystrophic axons and degenerating myelin sheaths (myelin figures) in spinal cord white matter; these changes are consistant with early degeneration of spinal cord white matter
This mouse can be used to support research in many areas including:agil related
Developmental Biology Research
Neurodevelopmental Defects
Postnatal Mortality
Neurobiology Research
Ataxia (Movement) Defects
Myelination Defects
Genes & Alleles
Gene & Allele Information
| Allele Symbol | agil | ||
|---|---|---|---|
| Allele Name | agitans-like | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | C3H/HeJ | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Optimizing PCR Protocols
References
References
Selected Reference(s)
Original article from The Mouse Mutant ResourceHarris BS; Ward-Bailey P; Bronson RT; Donahue LR. 2003. Agitans-like (agil), a suspected remutation to agitans (ag) on mouse Chromosome 14. Mouse Mutant Resources Web Site, The Jackson Laboratory, Bar Harbor, Maine (http://www.jax.org/mmr) MGI Direct Data Submission :. [MGI Ref ID J:84746]
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Weeks of Age Price* Gender Genotypes Provided Individual Mouse Price $127.90 Female or Male Heterozygous for agil *Price(s) in US dollars ($)
Pairs /Price* Pair Genotype $255.80 Heterozygous for agil x Heterozygous for agil
Additional Supply Details
| Supply Notes |
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| Pricing for International shipping destinations |
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Weeks of Age Price* Gender Genotypes Provided Individual Mouse Price $166.30 Female or Male Heterozygous for agil *Price(s) in US dollars ($)
Pairs /Price* Pair Genotype $332.60 Heterozygous for agil x Heterozygous for agil
Additional Supply Details
| Supply Notes |
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement. |
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| Supply Notes |
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| Important Note | This strain is homozygous for the retinal degeneration allele Pde6brd1. |
Control Information
| Control | ||
|---|---|---|
| +/? untyped from the colony | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
General Terms and Conditions
See Terms of Use
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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Contact Information
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Terms of Use
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Contact information
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| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
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