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| The LysMcre knock-in allele has a nuclear-localized Cre recombinase inserted into the first coding ATG of the lysozyme 2 gene (Lyz2); both abolishing endogenous Lyz2 gene function and placing NLS-Cre expression under the control of the endogenous Lyz2 promoter/enhancer elements. These LysMcre mice may be useful for Cre-lox studies of the myeloid cell lineage (monocytes, mature macrophages, and granulocytes) and the innate immune response. | |||||||||||||||||||
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Description
Strain Information
Former Names B6.129P2-Lyzstm1(cre)Ifo/J (Changed: 19-FEB-08 ) B6.129-Lyzstm1(cre)Ifo/J (Changed: 15-DEC-04 ) Type Congenic; Mutant Strain; Targeted Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Homozygote x Homozygote (Female x Male) 01-MAR-06 Species laboratory mouse Generation N6F?+N1F2 (28-DEC-12)
Generation DefinitionsDonating Investigator Irmgard Foerster, University of Duesseldorf Description
The LysMcre knock-in allele has a nuclear-localized Cre recombinase inserted into the first coding ATG of the lysozyme 2 gene (Lyz2); both abolishing endogenous Lyz2 gene function and placing NLS-Cre expression under the control of the endogenous Lyz2 promoter/enhancer elements. When crossed with a strain containing loxP site flanked sequence of interest, Cre-mediated recombination results in deletion of the targeted gene in the myeloid cell lineage, including monocytes, mature macrophages, and granulocytes. Mice that are homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. This strain represents an effective tool for generating myeloid cell-specific targeted mutants.View cre expression characterization.
Development
A targeting vector was designed to insert a frt-flanked neomycin resistance gene and Cre recombinase cDNA sequence (with nuclear localization signal) into the ATG-start site within exon 1 of the lysozyme 2 gene (Lyz2). The construct was electroporated into 129P2/OlaHsd-derived E14.1 embryonic stem (ES) cells. Correctly targeted ES cells were transiently transfected with a Flp expression vector to remove the frt-flanked neo cassette. ES cells that had successfully undergone Flp recombination were injected in blastocysts. The resulting chimeric animals were crossed to C57BL/6 mice. The donating investigator reported that mutant mice were then backcrossed to C57BL/6 mice for at least six generations prior to sending to The Jackson Laboratory Repository (see SNP notes below).A 32 SNP (single nucleotide polymorphism) panel analysis, with 27 markers covering all 19 chromosomes and the X chromosome, as well as 5 markers that distinguish between the C57BL/6J and C57BL/6N substrains, was performed on the rederived living colony at The Jackson Laboratory Repository. While the 27 markers throughout the genome suggested a C57BL/6 genetic background, 3 of 5 markers that determine C57BL/6J from C57BL/6N were found to be segregating. These data suggest the mice sent to The Jackson Laboratory Repository were on a mixed C57BL/6J ; C57BL/6N genetic background.
Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Lyz2tm1(cre)Ifo allele
019096 NOD.129P2(B6)-Lyz2tm1(cre)Ifo/NadlJ View Strains carrying Lyz2tm1(cre)Ifo (1 strain)
Additional Web Information
Introduction to Cre-lox technology
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * C57BL/6This mouse can be used to support research in many areas including:
cre relatedHematological Research
Hematopoietic Defects
Immunology, Inflammation and Autoimmunity Research
Autoimmunity
Immunodeficiency
Lymphoid Tissue Defects
hematopoietic development
Internal/Organ Research
Lymphoid Tissue Defects
Research Tools
Cre-lox System
Cre Recombinase Expression
Genetics Research
Tissue/Cell Markers
Tissue/Cell Markers: Cre-lox System
Immunology and Inflammation Research
Macrophage Deficiency
Lyz2tm1(cre)Ifo relatedResearch Tools
Cre-lox System
Developmental Biology Research
Internal/Organ Defects
Lymphoid Tissue Defects
Lymphoid Tissue Defects
hematopoietic defects
Hematological Research
Hematopoietic Defects
Immunological Defects
Neutrophil Defects
Immunology, Inflammation and Autoimmunity Research
Autoimmunity
experimentally induced rheumatoid arthritis
CD Antigens, Antigen Receptors, and Histocompatibility Markers
genes regulating susceptibility to infectious disease and endotoxin
Growth Factors/Receptors/Cytokines
Immunodeficiency
Neutrophil Defects
Inflammation
Neutrophil defects
Lymphoid Tissue Defects
hematopoietic development
Internal/Organ Research
Gastrointestinal Defects
Lymphoid Tissue Defects
Research Tools
Cancer Research
Leukemia
Cre-lox System
Cre Recombinase Expression
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Hematological Research
Immunology and Inflammation Research
Macrophage Deficiency
genes regulating susceptibility to infectious disease and endotoxin
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Lyz2tm1(cre)Ifo | ||
|---|---|---|---|
| Allele Name | targeted mutation 1, Irmgard Forster | ||
| Allele Type | Targeted (knock-in) | ||
| Common Name(s) | LCre; LC; Lys-cre; LysCre; LysM Cre; LysM-Cre; LysMCre; LysMCre; Lystm1(cre)Ifo; Lyz-cre; LyzCre; lysM/cre; | ||
| Mutation Made By | Irmgard Foerster, University of Duesseldorf | ||
| Strain of Origin | 129P2/OlaHsd | ||
| ES Cell Line Name | E14 | ||
| ES Cell Line Strain | 129P2/OlaHsd | ||
| Site of Expression | myeloid cells - including monocytes, mature macrophages, and granulocytes | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Driver Note | Lyz2 | ||
| Molecular Note | An NLS-cre gene was inserted into the endogenous ATG start site of the gene. An frt-flanked neomycin cassette was removed in ES cells via Flp-mediated recombination prior to production of chimeric mice. [MGI Ref ID J:67924] | ||
| Gene Symbol and Name | Lyz2, lysozyme 2 | ||
| Chromosome | 10 | ||
| Gene Common Name(s) | AI326280; Lys; Lysm; Lysz; Lyz; Lyz1; Lyzs; Lzm; Lzm-s1; Lzp; M lysozyme structural 1; expressed sequence AI326280; lysozyme; | ||
Genotyping
Genotyping Information
Genotyping Protocols
Lyz2tm1(cre)Ifo,Separated MCA
Lyz2tm1(cre)Ifo, Separated PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Clausen BE; Burkhardt C; Reith W; Renkawitz R; Forster I. 1999. Conditional gene targeting in macrophages and granulocytes using LysMcre mice. Transgenic Res 8(4):265-77. [PubMed: 10621974] [MGI Ref ID J:67924]
Additional References
Takeda K; Clausen BE; Kaisho T; Tsujimura T; Terada N; Forster I ; Akira S. 1999. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 10(1):39-49. [PubMed: 10023769] [MGI Ref ID J:53681]
Lyz2tm1(cre)Ifo relatedAbshire MY; Thomas KS; Owen KA; Bouton AH. 2011. Macrophage motility requires distinct {alpha}5{beta}1/FAK and {alpha}4{beta}1/paxillin signaling events. J Leukoc Biol 89(2):251-7. [PubMed: 21084629] [MGI Ref ID J:168496]
Acharya M; Mukhopadhyay S; Paidassi H; Jamil T; Chow C; Kissler S; Stuart LM; Hynes RO; Lacy-Hulbert A. 2010. alphav Integrin expression by DCs is required for Th17 cell differentiation and development of experimental autoimmune encephalomyelitis in mice. J Clin Invest 120(12):4445-52. [PubMed: 21099114] [MGI Ref ID J:171863]
Acharyya S; Villalta SA; Bakkar N; Bupha-Intr T; Janssen PM; Carathers M; Li ZW; Beg AA; Ghosh S; Sahenk Z; Weinstein M; Gardner KL; Rafael-Fortney JA; Karin M; Tidball JG; Baldwin AS; Guttridge DC. 2007. Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy. J Clin Invest 117(4):889-901. [PubMed: 17380205] [MGI Ref ID J:121279]
Alagbala Ajibade A; Wang Q; Cui J; Zou J; Xia X; Wang M; Tong Y; Hui W; Liu D; Su B; Wang HY; Wang RF. 2012. TAK1 Negatively Regulates NF-kappaB and p38 MAP Kinase Activation in Gr-1(+)CD11b(+) Neutrophils. Immunity 36(1):43-54. [PubMed: 22226633] [MGI Ref ID J:180736]
Albers J; Keller J; Baranowsky A; Beil FT; Catala-Lehnen P; Schulze J; Amling M; Schinke T. 2013. Canonical Wnt signaling inhibits osteoclastogenesis independent of osteoprotegerin. J Cell Biol 200(4):537-49. [PubMed: 23401003] [MGI Ref ID J:195205]
Aliprantis AO; Ueki Y; Sulyanto R; Park A; Sigrist KS; Sharma SM; Ostrowski MC; Olsen BR; Glimcher LH. 2008. NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism. J Clin Invest 118(11):3775-89. [PubMed: 18846253] [MGI Ref ID J:144598]
Allende ML; Bektas M; Lee BG; Bonifacino E; Kang J; Tuymetova G; Chen W; Saba JD; Proia RL. 2011. Sphingosine-1-phosphate lyase deficiency produces a pro-inflammatory response while impairing neutrophil trafficking. J Biol Chem 286(9):7348-58. [PubMed: 21173151] [MGI Ref ID J:170381]
Babaev VR; Yancey PG; Ryzhov SV; Kon V; Breyer MD; Magnuson MA; Fazio S; Linton MF. 2005. Conditional knockout of macrophage PPARgamma increases atherosclerosis in C57BL/6 and low-density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol 25(8):1647-53. [PubMed: 15947238] [MGI Ref ID J:114332]
Bai L; Constantinides MG; Thomas SY; Reboulet R; Meng F; Koentgen F; Teyton L; Savage PB; Bendelac A. 2012. Distinct APCs explain the cytokine bias of alpha-galactosylceramide variants in vivo. J Immunol 188(7):3053-61. [PubMed: 22393151] [MGI Ref ID J:183087]
Bai S; Kopan R; Zou W; Hilton MJ; Ong CT; Long F; Ross FP; Teitelbaum SL. 2008. NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells. J Biol Chem 283(10):6509-18. [PubMed: 18156632] [MGI Ref ID J:133664]
Baker AD; Malur A; Barna BP; Ghosh S; Kavuru MS; Malur AG; Thomassen MJ. 2010. Targeted PPAR{gamma} deficiency in alveolar macrophages disrupts surfactant catabolism. J Lipid Res 51(6):1325-31. [PubMed: 20064973] [MGI Ref ID J:161502]
Bakiri L; Reschke MO; Gefroh HA; Idarraga MH; Polzer K; Zenz R; Schett G; Wagner EF. 2011. Functions of Fos phosphorylation in bone homeostasis, cytokine response and tumourigenesis. Oncogene 30(13):1506-17. [PubMed: 21119595] [MGI Ref ID J:175064]
Balli D; Ren X; Chou FS; Cross E; Zhang Y; Kalinichenko VV; Kalin TV. 2012. Foxm1 transcription factor is required for macrophage migration during lung inflammation and tumor formation. Oncogene 31(34):3875-88. [PubMed: 22139074] [MGI Ref ID J:187794]
Baschant U; Frappart L; Rauchhaus U; Bruns L; Reichardt HM; Kamradt T; Brauer R; Tuckermann JP. 2011. Glucocorticoid therapy of antigen-induced arthritis depends on the dimerized glucocorticoid receptor in T cells. Proc Natl Acad Sci U S A 108(48):19317-22. [PubMed: 22084093] [MGI Ref ID J:180395]
Baumgartl J; Baudler S; Scherner M; Babaev V; Makowski L; Suttles J; McDuffie M; Tobe K; Kadowaki T; Fazio S; Kahn CR; Hotamisligil GS; Krone W; Linton M; Bruning JC. 2006. Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis. Cell Metab 3(4):247-56. [PubMed: 16581002] [MGI Ref ID J:129654]
Bayele HK; Peyssonnaux C; Giatromanolaki A; Arrais-Silva WW; Mohamed HS; Collins H; Giorgio S; Koukourakis M; Johnson RS; Blackwell JM; Nizet V; Srai SK. 2007. HIF-1 regulates heritable variation and allele expression phenotypes of the macrophage immune response gene SLC11A1 from a Z-DNA forming microsatellite. Blood 110(8):3039-48. [PubMed: 17606764] [MGI Ref ID J:148905]
Belikoff BG; Hatfield S; Georgiev P; Ohta A; Lukashev D; Buras JA; Remick DG; Sitkovsky M. 2011. A2B adenosine receptor blockade enhances macrophage-mediated bacterial phagocytosis and improves polymicrobial sepsis survival in mice. J Immunol 186(4):2444-53. [PubMed: 21242513] [MGI Ref ID J:169155]
Belikoff BG; Vaickus LJ; Sitkovsky M; Remick DG. 2012. A2B adenosine receptor expression by myeloid cells is proinflammatory in murine allergic-airway inflammation. J Immunol 189(7):3707-13. [PubMed: 22956582] [MGI Ref ID J:190542]
Benesova K; Vujic Spasic M; Schaefer SM; Stolte J; Baehr-Ivacevic T; Waldow K; Zhou Z; Klingmueller U; Benes V; Mall MA; Muckenthaler MU. 2012. Hfe deficiency impairs pulmonary neutrophil recruitment in response to inflammation. PLoS One 7(6):e39363. [PubMed: 22745741] [MGI Ref ID J:187935]
Bhattacharjee G; Ahamed J; Pawlinski R; Liu C; Mackman N; Ruf W; Edgington TS. 2008. Factor Xa binding to annexin 2 mediates signal transduction via protease-activated receptor 1. Circ Res 102(4):457-64. [PubMed: 18174463] [MGI Ref ID J:147663]
Bhattacharyya S; Brown DE; Brewer JA; Vogt SK; Muglia LJ. 2007. Macrophage glucocorticoid receptors regulate Toll-like receptor 4-mediated inflammatory responses by selective inhibition of p38 MAP kinase. Blood 109(10):4313-9. [PubMed: 17255352] [MGI Ref ID J:141671]
Bhattacharyya S; Ratajczak CK; Vogt SK; Kelley C; Colonna M; Schreiber RD; Muglia LJ. 2010. TAK1 targeting by glucocorticoids determines JNK and IkappaB regulation in Toll-like receptor-stimulated macrophages. Blood 115(10):1921-31. [PubMed: 20065289] [MGI Ref ID J:158841]
Bhattacharyya S; Zhao Y; Kay TW; Muglia LJ. 2011. Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor-induced STAT1 activation. Proc Natl Acad Sci U S A 108(23):9554-9. [PubMed: 21606371] [MGI Ref ID J:173334]
Bienvenu LA; Morgan J; Rickard AJ; Tesch GH; Cranston GA; Fletcher EK; Delbridge LM; Young MJ. 2012. Macrophage mineralocorticoid receptor signaling plays a key role in aldosterone-independent cardiac fibrosis. Endocrinology 153(7):3416-25. [PubMed: 22653557] [MGI Ref ID J:189110]
Bies J; Sramko M; Fares J; Rosu-Myles M; Zhang S; Koller R; Wolff L. 2010. Myeloid-specific inactivation of p15Ink4b results in monocytosis and predisposition to myeloid leukemia. Blood 116(6):979-87. [PubMed: 20457873] [MGI Ref ID J:163498]
Binder F; Hayakawa M; Choo MK; Sano Y; Park JM. 2013. Interleukin-4-induced beta-catenin regulates the conversion of macrophages to multinucleated giant cells. Mol Immunol 54(2):157-63. [PubMed: 23287596] [MGI Ref ID J:193264]
Boesten LS; Zadelaar AS; van Nieuwkoop A; Hu L; Jonkers J; van de Water B; Gijbels MJ; van der Made I; de Winther MP; Havekes LM; van Vlijmen BJ. 2006. Macrophage retinoblastoma deficiency leads to enhanced atherosclerosis development in ApoE-deficient mice. FASEB J 20(7):953-5. [PubMed: 16585057] [MGI Ref ID J:111494]
Bogunovic M; Ginhoux F; Helft J; Shang L; Hashimoto D; Greter M; Liu K; Jakubzick C; Ingersoll MA; Leboeuf M; Stanley ER; Nussenzweig M; Lira SA; Randolph GJ; Merad M. 2009. Origin of the lamina propria dendritic cell network. Immunity 31(3):513-25. [PubMed: 19733489] [MGI Ref ID J:152688]
Bonfield TL; Hodges CA; Cotton CU; Drumm ML. 2012. Absence of the cystic fibrosis transmembrane regulator (Cftr) from myeloid-derived cells slows resolution of inflammation and infection. J Leukoc Biol 92(5):1111-22. [PubMed: 22859830] [MGI Ref ID J:189685]
Bonfield TL; Thomassen MJ; Farver CF; Abraham S; Koloze MT; Zhang X; Mosser DM; Culver DA. 2008. Peroxisome proliferator-activated receptor-gamma regulates the expression of alveolar macrophage macrophage colony-stimulating factor. J Immunol 181(1):235-42. [PubMed: 18566389] [MGI Ref ID J:137408]
Bosschaerts T; Morias Y; Stijlemans B; Herin M; Porta C; Sica A; Mantovani A; De Baetselier P; Beschin A. 2011. IL-10 limits production of pathogenic TNF by M1 myeloid cells through induction of nuclear NF-kappaB p50 member in Trypanosoma congolense infection-resistant C57BL/6 mice. Eur J Immunol 41(11):3270-80. [PubMed: 21805465] [MGI Ref ID J:179528]
Bourquard N; Ng CJ; Reddy ST. 2011. Impaired hepatic insulin signalling in PON2-deficient mice: a novel role for the PON2/apoE axis on the macrophage inflammatory response. Biochem J 436(1):91-100. [PubMed: 21361875] [MGI Ref ID J:172089]
Bozec A; Bakiri L; Hoebertz A; Eferl R; Schilling AF; Komnenovic V; Scheuch H; Priemel M; Stewart CL; Amling M; Wagner EF. 2008. Osteoclast size is controlled by Fra-2 through LIF/LIF-receptor signalling and hypoxia. Nature 454(7201):221-5. [PubMed: 18548006] [MGI Ref ID J:137646]
Brunham LR; Singaraja RR; Duong M; Timmins JM; Fievet C; Bissada N; Kang MH; Samra A; Fruchart JC; McManus B; Staels B; Parks JS; Hayden MR. 2009. Tissue-specific roles of ABCA1 influence susceptibility to atherosclerosis. Arterioscler Thromb Vasc Biol 29(4):548-54. [PubMed: 19201688] [MGI Ref ID J:159775]
Brydges SD; Mueller JL; McGeough MD; Pena CA; Misaghi A; Gandhi C; Putnam CD; Boyle DL; Firestein GS; Horner AA; Soroosh P; Watford WT; O'Shea JJ; Kastner DL; Hoffman HM. 2009. Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity. Immunity 30(6):875-87. [PubMed: 19501000] [MGI Ref ID J:150054]
Bryson KJ; Millington OR; Mokgethi T; McGachy HA; Brombacher F; Alexander J. 2011. BALB/c Mice Deficient in CD4 T Cell IL-4Ralpha Expression Control Leishmania mexicana Load although Female but Not Male Mice Develop a Healer Phenotype. PLoS Negl Trop Dis 5(1):e930. [PubMed: 21245915] [MGI Ref ID J:168069]
Butcher BA; Kim L; Panopoulos AD; Watowich SS; Murray PJ; Denkers EY. 2005. IL-10-independent STAT3 activation by Toxoplasma gondii mediates suppression of IL-12 and TNF-alpha in host macrophages. J Immunol 174(6):3148-52. [PubMed: 15749841] [MGI Ref ID J:97691]
Buxade M; Lunazzi G; Minguillon J; Iborra S; Berga-Bolanos R; Del Val M; Aramburu J; Lopez-Rodriguez C. 2012. Gene expression induced by Toll-like receptors in macrophages requires the transcription factor NFAT5. J Exp Med 209(2):379-93. [PubMed: 22312110] [MGI Ref ID J:181691]
Caglayan E; Stauber B; Collins AR; Lyon CJ; Yin F; Liu J; Rosenkranz S; Erdmann E; Peterson LE; Ross RS; Tangirala RK; Hsueh WA. 2008. Differential roles of cardiomyocyte and macrophage peroxisome proliferator-activated receptor gamma in cardiac fibrosis. Diabetes 57(9):2470-9. [PubMed: 18511847] [MGI Ref ID J:141807]
Campbell L; Emmerson E; Davies F; Gilliver SC; Krust A; Chambon P; Ashcroft GS; Hardman MJ. 2010. Estrogen promotes cutaneous wound healing via estrogen receptor beta independent of its antiinflammatory activities. J Exp Med 207(9):1825-33. [PubMed: 20733032] [MGI Ref ID J:165719]
Cao X; Wei G; Fang H; Guo J; Weinstein M; Marsh CB; Ostrowski MC; Tridandapani S. 2004. The inositol 3-phosphatase PTEN negatively regulates Fc gamma receptor signaling, but supports Toll-like receptor 4 signaling in murine peritoneal macrophages. J Immunol 172(8):4851-7. [PubMed: 15067063] [MGI Ref ID J:89105]
Cao Y; Brombacher F; Tunyogi-Csapo M; Glant TT; Finnegan A. 2007. Interleukin-4 regulates proteoglycan-induced arthritis by specifically suppressing the innate immune response. Arthritis Rheum 56(3):861-70. [PubMed: 17330244] [MGI Ref ID J:168136]
Carlson BA; Yoo MH; Conrad M; Gladyshev VN; Hatfield DL; Park JM. 2011. Protein kinase-regulated expression and immune function of thioredoxin reductase 1 in mouse macrophages. Mol Immunol 49(1-2):311-6. [PubMed: 21943784] [MGI Ref ID J:177348]
Carow B; Ye X; Gavier-Widen D; Bhuju S; Oehlmann W; Singh M; Skold M; Ignatowicz L; Yoshimura A; Wigzell H; Rottenberg ME. 2011. Silencing suppressor of cytokine signaling-1 (SOCS1) in macrophages improves Mycobacterium tuberculosis control in an interferon-gamma (IFN-gamma)-dependent manner. J Biol Chem 286(30):26873-87. [PubMed: 21622562] [MGI Ref ID J:175389]
Castillo EF; Dekonenko A; Arko-Mensah J; Mandell MA; Dupont N; Jiang S; Delgado-Vargas M; Timmins GS; Bhattacharya D; Yang H; Hutt J; Lyons CR; Dobos KM; Deretic V. 2012. Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation. Proc Natl Acad Sci U S A 109(46):E3168-76. [PubMed: 23093667] [MGI Ref ID J:191229]
Cervantes-Barragan L; Kalinke U; Zust R; Konig M; Reizis B; Lopez-Macias C; Thiel V; Ludewig B. 2009. Type I IFN-mediated protection of macrophages and dendritic cells secures control of murine coronavirus infection. J Immunol 182(2):1099-106. [PubMed: 19124753] [MGI Ref ID J:143484]
Chaurasia B; Mauer J; Koch L; Goldau J; Kock AS; Bruning JC. 2010. Phosphoinositide-dependent kinase 1 provides negative feedback inhibition to Toll-like receptor-mediated NF-kappaB activation in macrophages. Mol Cell Biol 30(17):4354-66. [PubMed: 20584979] [MGI Ref ID J:163291]
Cheng S; Zhao SL; Nelson B; Kesavan C; Qin X; Wergedal J; Mohan S; Xing W. 2012. Targeted disruption of ephrin B1 in cells of myeloid lineage increases osteoclast differentiation and bone resorption in mice. PLoS One 7(3):e32887. [PubMed: 22403721] [MGI Ref ID J:186937]
Choi SH; Wiesner P; Almazan F; Kim J; Miller YI. 2012. Spleen tyrosine kinase regulates AP-1 dependent transcriptional response to minimally oxidized LDL. PLoS One 7(2):e32378. [PubMed: 22384232] [MGI Ref ID J:185297]
Chong MM; Metcalf D; Jamieson E; Alexander WS; Kay TW. 2005. Suppressor of cytokine signaling-1 in T cells and macrophages is critical for preventing lethal inflammation. Blood 106(5):1668-75. [PubMed: 15899915] [MGI Ref ID J:118492]
Clemens RA; Lenox LE; Kambayashi T; Bezman N; Maltzman JS; Nichols KE; Koretzky GA. 2007. Loss of SLP-76 expression within myeloid cells confers resistance to neutrophil-mediated tissue damage while maintaining effective bacterial killing. J Immunol 178(7):4606-14. [PubMed: 17372019] [MGI Ref ID J:145136]
Collazo MM; Paraiso KH; Park MY; Hazen AL; Kerr WG. 2012. Lineage extrinsic and intrinsic control of immunoregulatory cell numbers by SHIP. Eur J Immunol 42(7):1785-95. [PubMed: 22535653] [MGI Ref ID J:187777]
Corzo CA; Cotter MJ; Cheng P; Cheng F; Kusmartsev S; Sotomayor E; Padhya T; McCaffrey TV; McCaffrey JC; Gabrilovich DI. 2009. Mechanism regulating reactive oxygen species in tumor-induced myeloid-derived suppressor cells. J Immunol 182(9):5693-701. [PubMed: 19380816] [MGI Ref ID J:147709]
Coudriet GM; He J; Trucco M; Mars WM; Piganelli JD. 2010. Hepatocyte growth factor modulates interleukin-6 production in bone marrow derived macrophages: implications for inflammatory mediated diseases. PLoS One 5(11):e15384. [PubMed: 21072211] [MGI Ref ID J:166840]
Cramer T; Yamanishi Y; Clausen BE; Forster I; Pawlinski R; Mackman N; Haase VH; Jaenisch R; Corr M; Nizet V; Firestein GS; Gerber HP; Ferrara N; Johnson RS. 2003. HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell 112(5):645-57. [PubMed: 12628185] [MGI Ref ID J:107682]
Cremasco V; Benasciutti E; Cella M; Kisseleva M; Croke M; Faccio R. 2010. Phospholipase C gamma 2 is critical for development of a murine model of inflammatory arthritis by affecting actin dynamics in dendritic cells. PLoS One 5(1):e8909. [PubMed: 20111715] [MGI Ref ID J:157619]
Croker BA; Krebs DL; Zhang JG; Wormald S; Willson TA; Stanley EG; Robb L; Greenhalgh CJ; Forster I; Clausen BE; Nicola NA; Metcalf D; Hilton DJ; Roberts AW; Alexander WS. 2003. SOCS3 negatively regulates IL-6 signaling in vivo. Nat Immunol 4(6):540-5. [PubMed: 12754505] [MGI Ref ID J:83645]
Cucak H; Yrlid U; Reizis B; Kalinke U; Johansson-Lindbom B. 2009. Type I interferon signaling in dendritic cells stimulates the development of lymph-node-resident T follicular helper cells. Immunity 31(3):491-501. [PubMed: 19733096] [MGI Ref ID J:152690]
Dann A; Poeck H; Croxford AL; Gaupp S; Kierdorf K; Knust M; Pfeifer D; Maihoefer C; Endres S; Kalinke U; Meuth SG; Wiendl H; Knobeloch KP; Akira S; Waisman A; Hartmann G; Prinz M. 2012. Cytosolic RIG-I-like helicases act as negative regulators of sterile inflammation in the CNS. Nat Neurosci 15(1):98-106. [PubMed: 22138643] [MGI Ref ID J:180319]
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Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX12
Colony Maintenance
Breeding & Husbandry When maintaining the live colony, homozygous mice may be bred together. The expected coat color is black (non-agouti). Mating System Homozygote x Homozygote (Female x Male) 01-MAR-06 Diet Information LabDiet® 5K52/5K67
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $177.00 Female or Male Homozygous for Lyz2tm1(cre)Ifo
Price per Pair (US dollars $) Pair Genotype $354.00 Homozygous for Lyz2tm1(cre)Ifo x Homozygous for Lyz2tm1(cre)Ifo Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
| Pricing for International shipping destinations |
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Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $230.10 Female or Male Homozygous for Lyz2tm1(cre)Ifo
Price per Pair (US dollars $) Pair Genotype $460.20 Homozygous for Lyz2tm1(cre)Ifo x Homozygous for Lyz2tm1(cre)Ifo Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
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Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form
Terms of Use
Terms of Use
General Terms and Conditions
For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.
- Use of MICE by companies or for-profit entities requires a license.
Contact information
General inquiries regarding Terms of UseContracts Administration
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.