Strain Name:

B6.129P2-Lyz2tm1(cre)Ifo/J

Stock Number:

004781

Availability:

Repository- Live

Use Restrictions Apply, see Terms of Use

Description

Strain Information

Former Names B6.129P2-Lyzstm1(cre)Ifo/J    (Changed: 19-FEB-08 )
B6.129-Lyzstm1(cre)Ifo/J    (Changed: 15-DEC-04 )
Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Specieslaboratory mouse
GenerationN6F?+F12 (30-DEC-08)
 
Donating Investigator Irmgard Foerster,   University of Duesseldorf

Description
This strain expresses Cre recombinase from the endogenous Lyzs locus. When crossed with a strain containing loxP site flanked sequence of interest, Cre-mediated recombination results in deletion of the targeted gene in the myeloid cell lineage, including monocytes, mature macrophages, and granulocytes. Mice that are homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. This strain represents an effective tool for generating myeloid cell-specific targeted mutants.

Development
A targeting vector containing a FRT-flanked neomycin resistance gene, herpes simplex virus thymidine kinase genes and NLS (nuclear localization signal) -Cre cDNA, was inserted into the endogenous ATG-start site within exon 1 of the Lyzs gene. The construct was electroporated into 129P2/OlaHsd-derived E14.1 embryonic stem (ES) cells. Correctly targeted ES cells were transiently transfected with a Flp expression vector for the purpose of removing the selectable marker cassette. ES cells that had successfully undergone Flp recombination were injected in blastocysts.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of cre
004337   129(Cg)-Foxg1tm1(cre)Skm/J
008569   129-Alpltm1(cre)Nagy/J
003328   129-Tg(Prm-cre)58Og/J
005989   129;FVB-Tg(PTH-cre)4167Slib/J
007179   129S.Cg-Tg(UBC-cre/ESR1)1Ejb/J
007915   129S.FVB-Tg(Amh-cre)8815Reb/J
004302   129S1-Hprt1tm1(cre)Mnn/J
003960   129S6-Tg(Prnp-GFP/cre)1Blw/J
005697   B6.129-Otx1tm4(cre)Asim/J
004146   B6.129-Tg(Pcp2-cre)2Mpin/J
006785   B6.129P2(C)-Cd19tm1(cre)Cgn/J
006084   B6.129P2(Cg)-Foxg1tm1(cre)Skm/J
008710   B6.129P2-Hprt1tm10(Ple162-EGFP/cre)Ems/J
008877   B6.129P2-Hprt1tm12(Ple177-EGFP/cre)Ems/J
008709   B6.129P2-Hprt1tm9(Ple178-EGFP/cre)Ems/J
005623   B6.129S-Shhtm2(cre/ESR1)Cjt/J
006600   B6.129S1-Mnx1tm4(cre)Tmj/J
005628   B6.129S2-Emx1tm1(cre)Krj/J
003755   B6.129S4-Meox2tm1(cre)Sor/J
006878   B6.129S6-Taglntm2(cre)Yec/J
006054   B6.C-Tg(CMV-cre)1Cgn/J
009642   B6.Cg(129)-Tg(Gh1-cre)1Sac/J
006230   B6.Cg-Cebpatm1Dgt Tg(Mx1-cre)1Cgn/J
005622   B6.Cg-Shhtm1(EGFP/cre)Cjt/J
009616   B6.Cg-Tg(A930038C07Rik-cre)4Aibs/J
006149   B6.Cg-Tg(ACTA1-cre)79Jme/J
003574   B6.Cg-Tg(Alb-cre)21Mgn/J
006881   B6.Cg-Tg(Aqp2-cre)1Dek/J
004682   B6.Cg-Tg(CAG-cre/Esr1)5Amc/J
008520   B6.Cg-Tg(CD2-cre)4Kio/J
009350   B6.Cg-Tg(CDX2-cre)101Erf/J
009352   B6.Cg-Tg(CDX2-cre*)189Erf/J
005359   B6.Cg-Tg(Camk2a-cre)T29-1Stl/J
006137   B6.Cg-Tg(Cdh5-cre)7Mlia/J
006368   B6.Cg-Tg(Cr2-cre)3Cgn/J
006663   B6.Cg-Tg(Eno2-cre)39Jme/J
005069   B6.Cg-Tg(Fabp4-cre)1Rev/J
003573   B6.Cg-Tg(Ins2-cre)25Mgn/J
008068   B6.Cg-Tg(Itgax-cre)1-1Reiz/J
008781   B6.Cg-Tg(Kap-cre)29066/2Sig/J
003802   B6.Cg-Tg(Lck-cre)548Jxm/J
006889   B6.Cg-Tg(Lck-cre)I540Jxm/J
009643   B6.Cg-Tg(Lhb-cre)1Sac/J
003556   B6.Cg-Tg(Mx1-cre)1Cgn/J
007742   B6.Cg-Tg(Myh11-cre,-EGFP)2Mik/J
005657   B6.Cg-Tg(Myh6-cre/Esr1)1Jmk/J
008205   B6.Cg-Tg(NPHS2-cre)295Lbh/J
003771   B6.Cg-Tg(Nes-cre)1Kln/J
005975   B6.Cg-Tg(Plp1-cre/ESR1)3Pop/J
008827   B6.Cg-Tg(Prdm1-cre)1Masu/J
005584   B6.Cg-Tg(Prrx1-cre)1Cjt/J
003967   B6.Cg-Tg(Rbp3-cre)528Jxm/J
009613   B6.Cg-Tg(Scnn1a-cre)3Aibs/J
008454   B6.Cg-Tg(Sox2-cre)1Amc/J
006361   B6.Cg-Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/J
003966   B6.Cg-Tg(Syn1-cre)671Jxm/J
004128   B6.Cg-Tg(Tek-cre)12Flv/J
008863   B6.Cg-Tg(Tek-cre)1Ywa/J
008601   B6.Cg-Tg(Th-cre)1Tmd/J
007606   B6.Cg-Tg(Thy1-cre/ESR1,-EYFP)AGfng/J
008085   B6.Cg-Tg(UBC-cre/ESR1)1Ejb/J
008610   B6.Cg-Tg(Vav1-cre)A2Kio/J
008735   B6.Cg-Tg(Wap-cre)11738Mam/JKnwJ
009614   B6.Cg-Tg(Wfs1-cre/ERT2)2Aibs/J
006234   B6.Cg-Tg(tetO-cre)1Jaw/J
006475   B6.FVB(129S4)-Tg(Ckmm-cre)5Khn/J
006451   B6.FVB(129X1)-Tg(Sim1-cre)1Lowl/J
006333   B6.FVB(Cg)-Tg(Neurog3-cre)C1Able/J
003724   B6.FVB-Tg(EIIa-cre)C5379Lmgd/J
003394   B6.FVB-Tg(Zp3-cre)3Mrt/J
006660   B6.SJL-Slc6a3tm1.1(cre)Bkmn/J
004586   B6.SJL-Tg(Vil-cre)997Gum/J
003552   B6129-Tg(Wap-cre)11738Mam/J
004847   B6;129-Gt(ROSA)26Sortm1(cre/Esr1)Nat/J
008876   B6;129-Hprt1tm11(Ple176-EGFP/cre)Ems/J
005549   B6;129-Pax3tm1(cre)Joe/J
005650   B6;129-Tg(Myh6-cre/Esr1)1Jmk/J
008529   B6;129P-Tg(Neurog1-cre/ESR1)1Good/J
006668   B6;129P2-Omptm4(cre)Mom/MomJ
007001   B6;129S-Tg(UBC-cre/ESR1)1Ejb/J
006410   B6;129S6-Chattm1(cre)Lowl/J
008844   B6;C3-Tg(Ctgf-cre)2Aibs/J
008839   B6;C3-Tg(Cyp39a1-cre)1Aibs/J
009117   B6;C3-Tg(Cyp39a1-cre)7Aibs/J
008848   B6;C3-Tg(Mybpc1-cre)2Aibs/J
009111   B6;C3-Tg(Scnn1a-cre)1Aibs/J
009112   B6;C3-Tg(Scnn1a-cre)2Aibs/J
009103   B6;C3-Tg(Wfs1-cre/ERT2)3Aibs/J
003466   B6;D2-Tg(Sycp1-cre)4Min/J
008533   B6;FVB-Tg(Cspg4-cre)1Akik/J
003734   B6;FVB-Tg(GZMB-cre)1Jcb/J
004426   B6;SJL-Tg(Cga-cre)3Sac/J
003554   B6;SJL-Tg(Col2a1-cre)1Bhr/J
005249   B6;SJL-Tg(Krt1-15-cre/PGR)22Cot/J
007610   B6;SJL-Tg(Thy1-cre/ESR1,-EYFP)VGfng/J
007252   B6Ei.129S4-Tg(Prm-cre)58Og/EiJ
003465   BALB/c-Tg(CMV-cre)1Cgn/J
004126   C.Cg-Cd19tm1(cre)Cgn Ighb/J
005673   C.Cg-Tg(Mx1-cre)1Cgn/J
006244   C.Cg-Tg(tetO-cre)1Jaw/J
008766   C57BL/6-Tg(Cd8a-cre)1Itan/J
006474   C57BL/6-Tg(Grik4-cre)G32-4Stl/J
008314   C57BL/6-Tg(HBB-cre)12Kpe/J
008870   C57BL/6-Tg(Hspa2-cre)1Eddy/J
008535   C57BL/6-Tg(Pf4-cre)Q3Rsko/J
006888   C57BL/6-Tg(Zp3-cre)1Gwh/J
003651   C57BL/6-Tg(Zp3-cre)93Knw/J
007567   C57BL/6J-Tg(Itgax-cre,-EGFP)4097Ach/J
008661   C57BL/6J-Tg(Nkx2-1-cre)2Sand/J
006405   FVB-Tg(Ckmm-cre)5Khn/J
006774   FVB-Tg(Col2a1-cre/ESR1)KA3Smac/J
006954   FVB-Tg(Ddx4-cre)1Dcas/J
004600   FVB-Tg(GFAP-cre)25Mes/J
006364   FVB-Tg(Nr5a1-cre)2Lowl/J
008537   FVB-Tg(Tek-cre)2352Rwng/J
006139   FVB.Cg-Tg(ACTA1-cre)79Jme/J
006297   FVB.Cg-Tg(Eno2-cre)39Jme/J
008244   FVB.Cg-Tg(tetO-cre)1Jaw/J
003376   FVB/N-Tg(ACTB-cre)2Mrt/J
003314   FVB/N-Tg(EIIa-cre)C5379Lmgd/J
006143   FVB/N-Tg(Thy1-cre)1Vln/J
003377   FVB/N-Tg(Zp3-cre)3Mrt/J
005732   NOD.Cg-Tg(Lck-cre)548Jxm/AchJ
008694   NOD/ShiLt-Tg(Foxp3-EGFP/cre)1Jbs/J
004986   NOD/ShiLt-Tg(Ins2-cre)3Lt/Lt
003855   NOD/ShiLt-Tg(Ins2-cre)5Lt/LtJ
004987   NOD/ShiLt-Tg(Ins2-cre)6Lt/Lt
008464   STOCK Foxa2tm2.1(cre/Esr1)Moon/J
004192   STOCK Mttptm2Sgy Ldlrtm1Her Apobtm2Sgy Tg(Mx1-cre)1Cgn/J
006677   STOCK Olfr151tm28Mom/MomJ
007684   STOCK Tg(Atoh1-cre/ESR1)14Fsh/J
004453   STOCK Tg(CAG-cre/Esr1)5Amc/J
009615   STOCK Tg(Cartpt-cre)1Aibs/J
005105   STOCK Tg(Chx10-EGFP/cre,-ALPP)2Clc/J
008861   STOCK Tg(Ela1-Cre/ESR1)1Stof/J
005938   STOCK Tg(Eno2-cre)39Jme/J
004692   STOCK Tg(Hoxb7-cre)13Amc/J
008122   STOCK Tg(Ins2-cre/Esr1)1Dam/J
004782   STOCK Tg(KRT14-cre)1Amc/J
005107   STOCK Tg(KRT14-cre/Esr1)20Efu/J
008582   STOCK Tg(Kcnc2-Cre)K128Stl/LetJ
003551   STOCK Tg(MMTV-cre)1Mam/J
003553   STOCK Tg(MMTV-cre)4Mam/J
002527   STOCK Tg(Mx1-cre)1Cgn/J
009074   STOCK Tg(Myh6-cre)1Jmk/J
009102   STOCK Tg(Nefh-cre)12Kul/J
002858   STOCK Tg(Nes-cre)1Wme/J
002859   STOCK Tg(Nes-cre)2Wme/J
005667   STOCK Tg(Neurog3-cre)C1Able/J
008119   STOCK Tg(Neurog3-cre/Esr1)1Dam/J
006207   STOCK Tg(Pcp2-cre)1Amc/J
005965   STOCK Tg(Pomc1-cre)16Lowl/J
006395   STOCK Tg(Sim1-cre)1Lowl/J
009606   STOCK Tg(Six2-EGFP/cre)1Amc/J
004783   STOCK Tg(Sox2-cre)1Amc/J
008208   STOCK Tg(Stra8-cre)1Reb/J
004746   STOCK Tg(Tagln-cre)1Her/J
003829   STOCK Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J
007807   STOCK Tg(Wnt1-cre)11Rth/MileJ
008199   STOCK Tg(dlx6a-cre)1Mekk/J
002471   STOCK Tg(hCMV-cre)140Sau/J
006224   STOCK Tg(tetO-cre)1Jaw/J
View Strains carrying other alleles of cre     (162 strains)

Additional Web Information

Introduction to Cre-lox technology

Phenotype

Phenotype Information

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Hematological Research
Hematopoietic Defects

Immunology and Inflammation Research
Autoimmunity
Immunodeficiency
Lymphoid Tissue Defects
      hematopoietic development

Internal/Organ Research
Lymphoid Tissue Defects

Research Tools
Cre-lox System
      Cre Recombinase Expression
Genetics Research
      Tissue/Cell Markers: Cre-lox System
Immunology and Inflammation Research
      Macrophage Deficiency

cre related

Research Tools
Cre-lox System

Lyz2tm1(cre)Ifo related

Developmental Biology Research
Internal/Organ Defects
      Lymphoid Tissue Defects
Lymphoid Tissue Defects
      hematopoietic defects

Hematological Research
Hematopoietic Defects
Immunological Defects
Neutrophil Defects

Immunology and Inflammation Research
Autoimmunity
      experimentally induced rheumatoid arthritis
CD Antigens, Antigen Receptors, and Histocompatibility Markers
      genes regulating susceptibility to infectious disease and endotoxin
Growth Factors/Receptors/Cytokines
Immunodeficiency
      Neutrophil Defects
Inflammation
      Neutrophil defects
Lymphoid Tissue Defects
      hematopoietic development

Internal/Organ Research
Gastrointestinal Defects
Lymphoid Tissue Defects

Research Tools
Cancer Research
      Leukemia
Cre-lox System
      Cre Recombinase Expression
Genetics Research
      Mutagenesis and Transgenesis: Cre-lox System
Hematological Research
Immunology and Inflammation Research
      Macrophage Deficiency
      genes regulating susceptibility to infectious disease and endotoxin

Genes & Alleles

Gene & Allele Information

 
Allele Symbol Lyz2tm1(cre)Ifo
Allele Name targeted mutation 1, Irmgard Foerster
Allele Type Targeted (knock-in)
Common Name(s) LC; Lys-cre; LysM Cre; LysM-Cre; LysMCre; LysMCre; Lystm1(cre)Ifo; lysM/cre;
Mutation Made By Irmgard Foerster,   University of Duesseldorf
Strain of Origin129P2/OlaHsd
ES Cell Line NameE14
ES Cell Line Strain129P2/OlaHsd
Site of Expressionmyeloid cells - including monocytes, mature macrophages, and granulocytes
Expressed Gene cre, cre recombinase, bacteriophage P1
Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence.
Gene Symbol and Name Lyz2, lysozyme 2
Chromosome 10
Gene Common Name(s) AI326280; LZM; Lys; Lysz; Lyz; Lyzs; Lzm-s1; Lzp; M lysozyme structural 1; expressed sequence AI326280; lysozyme;
Driver Note Lyz2
Molecular Note An NLS-cre gene was inserted into the endogenous ATG start site of the gene. An frt-flanked neomycin cassette was removed in ES cells via Flp-mediated recombination prior to production of chimeric mice. [MGI Ref ID J:67924]
 

Genotyping

Genotyping Information

Genotyping Protocols

Lyz2tm1(cre)Ifo, Separated PCR

Helpful Links

Genotyping resources and troubleshooting

References

References

Selected Reference(s)

Clausen BE; Burkhardt C; Reith W; Renkawitz R; Forster I. 1999. Conditional gene targeting in macrophages and granulocytes using LysMcre mice. Transgenic Res 8(4):265-77. [PubMed: 10621974]  [MGI Ref ID J:67924]

Additional References

Takeda K; Clausen BE; Kaisho T; Tsujimura T; Terada N; Forster I ; Akira S. 1999. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 10(1):39-49. [PubMed: 10023769]  [MGI Ref ID J:53681]

Lyz2tm1(cre)Ifo related

Acharyya S; Villalta SA; Bakkar N; Bupha-Intr T; Janssen PM; Carathers M; Li ZW; Beg AA; Ghosh S; Sahenk Z; Weinstein M; Gardner KL; Rafael-Fortney JA; Karin M; Tidball JG; Baldwin AS; Guttridge DC. 2007. Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy. J Clin Invest 117(4):889-901. [PubMed: 17380205]  [MGI Ref ID J:121279]

Aliprantis AO; Ueki Y; Sulyanto R; Park A; Sigrist KS; Sharma SM; Ostrowski MC; Olsen BR; Glimcher LH. 2008. NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism. J Clin Invest 118(11):3775-89. [PubMed: 18846253]  [MGI Ref ID J:144598]

Babaev VR; Yancey PG; Ryzhov SV; Kon V; Breyer MD; Magnuson MA; Fazio S; Linton MF. 2005. Conditional knockout of macrophage PPARgamma increases atherosclerosis in C57BL/6 and low-density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol 25(8):1647-53. [PubMed: 15947238]  [MGI Ref ID J:114332]

Bai S; Kopan R; Zou W; Hilton MJ; Ong CT; Long F; Ross FP; Teitelbaum SL. 2008. NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells. J Biol Chem 283(10):6509-18. [PubMed: 18156632]  [MGI Ref ID J:133664]

Baumgartl J; Baudler S; Scherner M; Babaev V; Makowski L; Suttles J; McDuffie M; Tobe K; Kadowaki T; Fazio S; Kahn CR; Hotamisligil GS; Krone W; Linton M; Bruning JC. 2006. Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis. Cell Metab 3(4):247-56. [PubMed: 16581002]  [MGI Ref ID J:129654]

Bayele HK; Peyssonnaux C; Giatromanolaki A; Arrais-Silva WW; Mohamed HS; Collins H; Giorgio S; Koukourakis M; Johnson RS; Blackwell JM; Nizet V; Srai SK. 2007. HIF-1 regulates heritable variation and allele expression phenotypes of the macrophage immune response gene SLC11A1 from a Z-DNA forming microsatellite. Blood 110(8):3039-48. [PubMed: 17606764]  [MGI Ref ID J:148905]

Bhattacharjee G; Ahamed J; Pawlinski R; Liu C; Mackman N; Ruf W; Edgington TS. 2008. Factor Xa binding to annexin 2 mediates signal transduction via protease-activated receptor 1. Circ Res 102(4):457-64. [PubMed: 18174463]  [MGI Ref ID J:147663]

Bhattacharyya S; Brown DE; Brewer JA; Vogt SK; Muglia LJ. 2007. Macrophage glucocorticoid receptors regulate Toll-like receptor 4-mediated inflammatory responses by selective inhibition of p38 MAP kinase. Blood 109(10):4313-9. [PubMed: 17255352]  [MGI Ref ID J:141671]

Boesten LS; Zadelaar AS; van Nieuwkoop A; Hu L; Jonkers J; van de Water B; Gijbels MJ; van der Made I; de Winther MP; Havekes LM; van Vlijmen BJ. 2006. Macrophage retinoblastoma deficiency leads to enhanced atherosclerosis development in ApoE-deficient mice. FASEB J 20(7):953-5. [PubMed: 16585057]  [MGI Ref ID J:111494]

Bogunovic M; Ginhoux F; Helft J; Shang L; Hashimoto D; Greter M; Liu K; Jakubzick C; Ingersoll MA; Leboeuf M; Stanley ER; Nussenzweig M; Lira SA; Randolph GJ; Merad M. 2009. Origin of the lamina propria dendritic cell network. Immunity 31(3):513-25. [PubMed: 19733489]  [MGI Ref ID J:152688]

Bonfield TL; Thomassen MJ; Farver CF; Abraham S; Koloze MT; Zhang X; Mosser DM; Culver DA. 2008. Peroxisome proliferator-activated receptor-gamma regulates the expression of alveolar macrophage macrophage colony-stimulating factor. J Immunol 181(1):235-42. [PubMed: 18566389]  [MGI Ref ID J:137408]

Bozec A; Bakiri L; Hoebertz A; Eferl R; Schilling AF; Komnenovic V; Scheuch H; Priemel M; Stewart CL; Amling M; Wagner EF. 2008. Osteoclast size is controlled by Fra-2 through LIF/LIF-receptor signalling and hypoxia. Nature 454(7201):221-5. [PubMed: 18548006]  [MGI Ref ID J:137646]

Brydges SD; Mueller JL; McGeough MD; Pena CA; Misaghi A; Gandhi C; Putnam CD; Boyle DL; Firestein GS; Horner AA; Soroosh P; Watford WT; O'Shea JJ; Kastner DL; Hoffman HM. 2009. Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity. Immunity 30(6):875-87. [PubMed: 19501000]  [MGI Ref ID J:150054]

Butcher BA; Kim L; Panopoulos AD; Watowich SS; Murray PJ; Denkers EY. 2005. IL-10-independent STAT3 activation by Toxoplasma gondii mediates suppression of IL-12 and TNF-alpha in host macrophages. J Immunol 174(6):3148-52. [PubMed: 15749841]  [MGI Ref ID J:97691]

Caglayan E; Stauber B; Collins AR; Lyon CJ; Yin F; Liu J; Rosenkranz S; Erdmann E; Peterson LE; Ross RS; Tangirala RK; Hsueh WA. 2008. Differential roles of cardiomyocyte and macrophage peroxisome proliferator-activated receptor gamma in cardiac fibrosis. Diabetes 57(9):2470-9. [PubMed: 18511847]  [MGI Ref ID J:141807]

Cao X; Wei G; Fang H; Guo J; Weinstein M; Marsh CB; Ostrowski MC; Tridandapani S. 2004. The inositol 3-phosphatase PTEN negatively regulates Fc gamma receptor signaling, but supports Toll-like receptor 4 signaling in murine peritoneal macrophages. J Immunol 172(8):4851-7. [PubMed: 15067063]  [MGI Ref ID J:89105]

Cervantes-Barragan L; Kalinke U; Zust R; Konig M; Reizis B; Lopez-Macias C; Thiel V; Ludewig B. 2009. Type I IFN-mediated protection of macrophages and dendritic cells secures control of murine coronavirus infection. J Immunol 182(2):1099-106. [PubMed: 19124753]  [MGI Ref ID J:143484]

Chong MM; Metcalf D; Jamieson E; Alexander WS; Kay TW. 2005. Suppressor of cytokine signaling-1 in T cells and macrophages is critical for preventing lethal inflammation. Blood 106(5):1668-75. [PubMed: 15899915]  [MGI Ref ID J:118492]

Clemens RA; Lenox LE; Kambayashi T; Bezman N; Maltzman JS; Nichols KE; Koretzky GA. 2007. Loss of SLP-76 expression within myeloid cells confers resistance to neutrophil-mediated tissue damage while maintaining effective bacterial killing. J Immunol 178(7):4606-14. [PubMed: 17372019]  [MGI Ref ID J:145136]

Corzo CA; Cotter MJ; Cheng P; Cheng F; Kusmartsev S; Sotomayor E; Padhya T; McCaffrey TV; McCaffrey JC; Gabrilovich DI. 2009. Mechanism regulating reactive oxygen species in tumor-induced myeloid-derived suppressor cells. J Immunol 182(9):5693-701. [PubMed: 19380816]  [MGI Ref ID J:147709]

Cramer T; Yamanishi Y; Clausen BE; Forster I; Pawlinski R; Mackman N; Haase VH; Jaenisch R; Corr M; Nizet V; Firestein GS; Gerber HP; Ferrara N; Johnson RS. 2003. HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell 112(5):645-57. [PubMed: 12628185]  [MGI Ref ID J:107682]

Cucak H; Yrlid U; Reizis B; Kalinke U; Johansson-Lindbom B. 2009. Type I interferon signaling in dendritic cells stimulates the development of lymph-node-resident T follicular helper cells. Immunity 31(3):491-501. [PubMed: 19733096]  [MGI Ref ID J:152690]

Dzhagalov I; St John A; He YW. 2007. The antiapoptotic protein Mcl-1 is essential for the survival of neutrophils but not macrophages. Blood 109(4):1620-6. [PubMed: 17062731]  [MGI Ref ID J:137502]

Eash KJ; Means JM; White DW; Link DC. 2009. CXCR4 is a key regulator of neutrophil release from the bone marrow under basal and stress granulopoiesis conditions. Blood 113(19):4711-9. [PubMed: 19264920]  [MGI Ref ID J:150156]

El Kasmi KC; Holst J; Coffre M; Mielke L; de Pauw A; Lhocine N; Smith AM; Rutschman R; Kaushal D; Shen Y; Suda T; Donnelly RP; Myers MG Jr; Alexander W; Vignali DA; Watowich SS; Ernst M; Hilton DJ; Murray PJ. 2006. General nature of the STAT3-activated anti-inflammatory response. J Immunol 177(11):7880-8. [PubMed: 17114459]  [MGI Ref ID J:140695]

El Kasmi KC; Qualls JE; Pesce JT; Smith AM; Thompson RW; Henao-Tamayo M; Basaraba RJ; Konig T; Schleicher U; Koo MS; Kaplan G; Fitzgerald KA; Tuomanen EI; Orme IM; Kanneganti TD; Bogdan C; Wynn TA; Murray PJ. 2008. Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens. Nat Immunol 9(12):1399-406. [PubMed: 18978793]  [MGI Ref ID J:143229]

El Kasmi KC; Smith AM; Williams L; Neale G; Panopolous A; Watowich SS; Hacker H; Foxwell BM; Murray PJ. 2007. Cutting edge: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway. J Immunol 179(11):7215-9. [PubMed: 18025162]  [MGI Ref ID J:133009]

Fong CH; Bebien M; Didierlaurent A; Nebauer R; Hussell T; Broide D; Karin M; Lawrence T. 2008. An antiinflammatory role for IKKbeta through the inhibition of 'classical' macrophage activation. J Exp Med 205(6):1269-76. [PubMed: 18490491]  [MGI Ref ID J:137075]

Gallina G; Dolcetti L; Serafini P; De Santo C; Marigo I; Colombo MP; Basso G; Brombacher F; Borrello I; Zanovello P; Bicciato S; Bronte V. 2006. Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells. J Clin Invest 116(10):2777-90. [PubMed: 17016559]  [MGI Ref ID J:114986]

Gaultier A; Arandjelovic S; Niessen S; Overton CD; Linton MF; Fazio S; Campana WM; Cravatt BF rd; Gonias SL. 2008. Regulation of tumor necrosis factor receptor-1 and the IKK-NF-kappaB pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor. Blood 111(11):5316-25. [PubMed: 18369152]  [MGI Ref ID J:136163]

Glogauer M; Marchal CC; Zhu F; Worku A; Clausen BE; Foerster I; Marks P; Downey GP; Dinauer M; Kwiatkowski DJ. 2003. Rac1 deletion in mouse neutrophils has selective effects on neutrophil functions. J Immunol 170(11):5652-7. [PubMed: 12759446]  [MGI Ref ID J:83457]

Goren I; Allmann N; Yogev N; Schurmann C; Linke A; Holdener M; Waisman A; Pfeilschifter J; Frank S. 2009. A transgenic mouse model of inducible macrophage depletion: effects of diphtheria toxin-driven lysozyme M-specific cell lineage ablation on wound inflammatory, angiogenic, and contractive processes. Am J Pathol 175(1):132-47. [PubMed: 19528348]  [MGI Ref ID J:150035]

Greten FR; Arkan MC; Bollrath J; Hsu LC; Goode J; Miething C; Goktuna SI; Neuenhahn M; Fierer J; Paxian S; Van Rooijen N; Xu Y; O'Cain T; Jaffee BB; Busch DH; Duyster J; Schmid RM; Eckmann L; Karin M. 2007. NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta. Cell 130(5):918-31. [PubMed: 17803913]  [MGI Ref ID J:129928]

Greten FR; Eckmann L; Greten TF; Park JM; Li ZW; Egan LJ; Kagnoff MF; Karin M. 2004. IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 118(3):285-96. [PubMed: 15294155]  [MGI Ref ID J:91947]

Grivennikov SI; Tumanov AV; Liepinsh DJ; Kruglov AA; Marakusha BI; Shakhov AN; Murakami T; Drutskaya LN; Forster I; Clausen BE; Tessarollo L; Ryffel B; Kuprash DV; Nedospasov SA. 2005. Distinct and nonredundant in vivo functions of TNF produced by t cells and macrophages/neutrophils: protective and deleterious effects. Immunity 22(1):93-104. [PubMed: 15664162]  [MGI Ref ID J:95684]

Hall AB; Gakidis MA; Glogauer M; Wilsbacher JL; Gao S; Swat W; Brugge JS. 2006. Requirements for Vav guanine nucleotide exchange factors and Rho GTPases in FcgammaR- and complement-mediated phagocytosis. Immunity 24(3):305-16. [PubMed: 16546099]  [MGI Ref ID J:113323]

Hashimoto M; Ayada T; Kinjyo I; Hiwatashi K; Yoshida H; Okada Y; Kobayashi T; Yoshimura A. 2009. Silencing of SOCS1 in macrophages suppresses tumor development by enhancing antitumor inflammation. Cancer Sci 100(4):730-6. [PubMed: 19469017]  [MGI Ref ID J:150670]

Hasselblatt P; Gresh L; Kudo H; Guinea-Viniegra J; Wagner EF. 2008. The role of the transcription factor AP-1 in colitis-associated and beta-catenin-dependent intestinal tumorigenesis in mice. Oncogene 27(47):6102-9. [PubMed: 18679426]  [MGI Ref ID J:140139]

Herbert DR; Holscher C; Mohrs M; Arendse B; Schwegmann A; Radwanska M; Leeto M; Kirsch R; Hall P; Mossmann H; Claussen B; Forster I; Brombacher F. 2004. Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology. Immunity 20(5):623-35. [PubMed: 15142530]  [MGI Ref ID J:114751]

Hevener AL; Olefsky JM; Reichart D; Nguyen MT; Bandyopadyhay G; Leung HY; Watt MJ; Benner C; Febbraio MA; Nguyen AK; Folian B; Subramaniam S; Gonzalez FJ; Glass CK; Ricote M. 2007. Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones. J Clin Invest 117(6):1658-69. [PubMed: 17525798]  [MGI Ref ID J:122186]

Holscher C; Arendse B; Schwegmann A; Myburgh E; Brombacher F. 2006. Impairment of alternative macrophage activation delays cutaneous leishmaniasis in nonhealing BALB/c mice. J Immunol 176(2):1115-21. [PubMed: 16394000]  [MGI Ref ID J:126442]

Horiguchi N; Wang L; Mukhopadhyay P; Park O; Jeong WI; Lafdil F; Osei-Hyiaman D; Moh A; Fu XY; Pacher P; Kunos G; Gao B. 2008. Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury. Gastroenterology 134(4):1148-58. [PubMed: 18395093]  [MGI Ref ID J:136121]

Horiuchi K; Kimura T; Miyamoto T; Takaishi H; Okada Y; Toyama Y; Blobel CP. 2007. Cutting edge: TNF-alpha-converting enzyme (TACE/ADAM17) inactivation in mouse myeloid cells prevents lethality from endotoxin shock. J Immunol 179(5):2686-9. [PubMed: 17709479]  [MGI Ref ID J:139846]

Hu L; Boesten LS; May P; Herz J; Bovenschen N; Huisman MV; Berbee JF; Havekes LM; van Vlijmen BJ; Tamsma JT. 2006. Macrophage low-density lipoprotein receptor-related protein deficiency enhances atherosclerosis in ApoE/LDLR double knockout mice. Arterioscler Thromb Vasc Biol 26(12):2710-5. [PubMed: 17038633]  [MGI Ref ID J:129557]

Hu X; Chung AY; Wu I; Foldi J; Chen J; Ji JD; Tateya T; Kang YJ; Han J; Gessler M; Kageyama R; Ivashkiv LB. 2008. Integrated regulation of Toll-like receptor responses by Notch and interferon-gamma pathways. Immunity 29(5):691-703. [PubMed: 18976936]  [MGI Ref ID J:143772]

Imai Y; Kuba K; Neely GG; Yaghubian-Malhami R; Perkmann T; van Loo G; Ermolaeva M; Veldhuizen R; Leung YH; Wang H; Liu H; Sun Y; Pasparakis M; Kopf M; Mech C; Bavari S; Peiris JS; Slutsky AS; Akira S; Hultqvist M; Holmdahl R; Nicholls J; Jiang C; Binder CJ; Penninger JM. 2008. Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell 133(2):235-49. [PubMed: 18423196]  [MGI Ref ID J:145306]

Jakubzick C; Bogunovic M; Bonito AJ; Kuan EL; Merad M; Randolph GJ. 2008. Lymph-migrating, tissue-derived dendritic cells are minor constituents within steady-state lymph nodes. J Exp Med 205(12):2839-50. [PubMed: 18981237]  [MGI Ref ID J:143220]

Jennewein C; Kuhn AM; Schmidt MV; Meilladec-Jullig V; von Knethen A; Gonzalez FJ; Brune B. 2008. Sumoylation of peroxisome proliferator-activated receptor gamma by apoptotic cells prevents lipopolysaccharide-induced NCoR removal from kappaB binding sites mediating transrepression of proinflammatory cytokines. J Immunol 181(8):5646-52. [PubMed: 18832723]  [MGI Ref ID J:140756]

Johnnidis JB; Harris MH; Wheeler RT; Stehling-Sun S; Lam MH; Kirak O; Brummelkamp TR; Fleming MD; Camargo FD. 2008. Regulation of progenitor cell proliferation and granulocyte function by microRNA-223. Nature 451(7182):1125-9. [PubMed: 18278031]  [MGI Ref ID J:140009]

Jude CD; Climer L; Xu D; Artinger E; Fisher JK; Ernst P. 2007. Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors. Cell Stem Cell 1(3):324-37. [PubMed: 18371366]  [MGI Ref ID J:147265]

Kang K; Reilly SM; Karabacak V; Gangl MR; Fitzgerald K; Hatano B; Lee CH. 2008. Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity. Cell Metab 7(6):485-95. [PubMed: 18522830]  [MGI Ref ID J:137033]

Kang TB; Ben-Moshe T; Varfolomeev EE; Pewzner-Jung Y; Yogev N; Jurewicz A; Waisman A; Brenner O; Haffner R; Gustafsson E; Ramakrishnan P; Lapidot T; Wallach D. 2004. Caspase-8 serves both apoptotic and nonapoptotic roles. J Immunol 173(5):2976-84. [PubMed: 15322156]  [MGI Ref ID J:92722]

Kang YJ; Chen J; Otsuka M; Mols J; Ren S; Wang Y; Han J. 2008. Macrophage Deletion of p38{alpha} Partially Impairs Lipopolysaccharide-Induced Cellular Activation. J Immunol 180(7):5075-82. [PubMed: 18354233]  [MGI Ref ID J:133368]

Kanters E; Pasparakis M; Gijbels MJ; Vergouwe MN; Partouns-Hendriks I; Fijneman RJ; Clausen BE; Forster I; Kockx MM; Rajewsky K; Kraal G; Hofker MH; de Winther MP. 2003. Inhibition of NF-kappaB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice. J Clin Invest 112(8):1176-85. [PubMed: 14561702]  [MGI Ref ID J:86163]

Karlsson MC; Guinamard R; Bolland S; Sankala M; Steinman RM; Ravetch JV. 2003. Macrophages control the retention and trafficking of B lymphocytes in the splenic marginal zone. J Exp Med 198(2):333-40. [PubMed: 12874264]  [MGI Ref ID J:119256]

Kasorn A; Alcaide P; Jia Y; Subramanian KK; Sarraj B; Li Y; Loison F; Hattori H; Silberstein LE; Luscinskas WF; Luo HR. 2009. Focal adhesion kinase regulates pathogen-killing capability and life span of neutrophils via mediating both adhesion-dependent and -independent cellular signals. J Immunol 183(2):1032-43. [PubMed: 19561112]  [MGI Ref ID J:151655]

Kasper LH; Fukuyama T; Biesen MA; Boussouar F; Tong C; de Pauw A; Murray PJ; van Deursen JM; Brindle PK. 2006. Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development. Mol Cell Biol 26(3):789-809. [PubMed: 16428436]  [MGI Ref ID J:105505]

Kenner L; Hoebertz A; Beil T; Keon N; Karreth F; Eferl R; Scheuch H; Szremska A; Amling M; Schorpp-Kistner M; Angel P; Wagner EF. 2004. Mice lacking JunB are osteopenic due to cell-autonomous osteoblast and osteoclast defects. J Cell Biol 164(4):613-23. [PubMed: 14769860]  [MGI Ref ID J:88126]

Kim C; Sano Y; Todorova K; Carlson BA; Arpa L; Celada A; Lawrence T; Otsu K; Brissette JL; Arthur JS; Park JM. 2008. The kinase p38 alpha serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression. Nat Immunol 9(9):1019-27. [PubMed: 18677317]  [MGI Ref ID J:140029]

Kimura A; Kinjyo I; Matsumura Y; Mori H; Mashima R; Harada M; Chien KR; Yasukawa H; Yoshimura A. 2004. SOCS3 is a physiological negative regulator for granulopoiesis and granulocyte colony-stimulating factor receptor signaling. J Biol Chem 279(8):6905-10. [PubMed: 14699146]  [MGI Ref ID J:88961]

Kobayashi M; Kweon MN; Kuwata H; Schreiber RD; Kiyono H; Takeda K; Akira S. 2003. Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice. J Clin Invest 111(9):1297-308. [PubMed: 12727921]  [MGI Ref ID J:83280]

Kontoyiannis D; Boulougouris G; Manoloukos M; Armaka M; Apostolaki M; Pizarro T; Kotlyarov A; Forster I; Flavell R; Gaestel M; Tsichlis P; Cominelli F; Kollias G. 2002. Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease. J Exp Med 196(12):1563-74. [PubMed: 12486099]  [MGI Ref ID J:108572]

Kuroda S; Nishio M; Sasaki T; Horie Y; Kawahara K; Sasaki M; Natsui M; Matozaki T; Tezuka H; Ohteki T; Forster I; Mak TW; Nakano T; Suzuki A. 2008. Effective clearance of intracellular Leishmania major in vivo requires Pten in macrophages. Eur J Immunol 38(5):1331-40. [PubMed: 18398930]  [MGI Ref ID J:133966]

Lacy-Hulbert A; Smith AM; Tissire H; Barry M; Crowley D; Bronson RT; Roes JT; Savill JS; Hynes RO. 2007. Ulcerative colitis and autoimmunity induced by loss of myeloid alphav integrins. Proc Natl Acad Sci U S A 104(40):15823-8. [PubMed: 17895374]  [MGI Ref ID J:125508]

Li Y; Jia Y; Pichavant M; Loison F; Sarraj B; Kasorn A; You J; Robson BE; Umetsu DT; Mizgerd JP; Ye K; Luo HR. 2009. Targeted deletion of tumor suppressor PTEN augments neutrophil function and enhances host defense in neutropenia-associated pneumonia. Blood 113(20):4930-41. [PubMed: 19286998]  [MGI Ref ID J:148947]

Lillis AP; Greenlee MC; Mikhailenko I; Pizzo SV; Tenner AJ; Strickland DK; Bohlson SS. 2008. Murine low-density lipoprotein receptor-related protein 1 (LRP) is required for phagocytosis of targets bearing LRP ligands but is not required for C1q-triggered enhancement of phagocytosis. J Immunol 181(1):364-73. [PubMed: 18566402]  [MGI Ref ID J:137404]

Luyendyk JP; Schabbauer GA; Tencati M; Holscher T; Pawlinski R; Mackman N. 2008. Genetic Analysis of the Role of the PI3K-Akt Pathway in Lipopolysaccharide-Induced Cytokine and Tissue Factor Gene Expression in Monocytes/Macrophages. J Immunol 180(6):4218-26. [PubMed: 18322234]  [MGI Ref ID J:132956]

Mabrouk I; Buart S; Hasmim M; Michiels C; Connault E; Opolon P; Chiocchia G; Levi-Strauss M; Chouaib S; Karray S. 2008. Prevention of autoimmunity and control of recall response to exogenous antigen by Fas death receptor ligand expression on T cells. Immunity 29(6):922-33. [PubMed: 19013083]  [MGI Ref ID J:142793]

Maeda S; Kamata H; Luo JL; Leffert H; Karin M. 2005. IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 121(7):977-90. [PubMed: 15989949]  [MGI Ref ID J:115107]

Magez S; Radwanska M; Drennan M; Fick L; Baral TN; Allie N; Jacobs M; Nedospasov S; Brombacher F; Ryffel B; De Baetselier P. 2007. Tumor necrosis factor (TNF) receptor-1 (TNFp55) signal transduction and macrophage-derived soluble TNF are crucial for nitric oxide-mediated Trypanosoma congolense parasite killing. J Infect Dis 196(6):954-62. [PubMed: 17703428]  [MGI Ref ID J:145248]

Malur A; Mccoy AJ; Arce S; Barna BP; Kavuru MS; Malur AG; Thomassen MJ. 2009. Deletion of PPARgamma in alveolar macrophages is associated with a Th-1 pulmonary inflammatory response. J Immunol 182(9):5816-22. [PubMed: 19380830]  [MGI Ref ID J:147703]

Matsukawa A; Kudo S; Maeda T; Numata K; Watanabe H; Takeda K; Akira S; Ito T. 2005. Stat3 in resident macrophages as a repressor protein of inflammatory response. J Immunol 175(5):3354-9. [PubMed: 16116228]  [MGI Ref ID J:113215]

Matsumura Y; Kobayashi T; Ichiyama K; Yoshida R; Hashimoto M; Takimoto T; Tanaka K; Chinen T; Shichita T; Wyss-Coray T; Sato K; Yoshimura A. 2007. Selective expansion of foxp3-positive regulatory T cells and immunosuppression by suppressors of cytokine signaling 3-deficient dendritic cells. J Immunol 179(4):2170-9. [PubMed: 17675476]  [MGI Ref ID J:151229]

Milovanova TN; Bhopale VM; Sorokina EM; Moore JS; Hunt TK; Hauer-Jensen M; Velazquez OC; Thom SR. 2008. Lactate stimulates vasculogenic stem cells via the thioredoxin system and engages an autocrine activation loop involving hypoxia-inducible factor 1. Mol Cell Biol 28(20):6248-61. [PubMed: 18710947]  [MGI Ref ID J:140963]

Necela BM; Su W; Thompson EA. 2008. Toll-like receptor 4 mediates cross-talk between peroxisome proliferator-activated receptor gamma and nuclear factor-kappaB in macrophages. Immunology 125(3):344-58. [PubMed: 18422969]  [MGI Ref ID J:144451]

Nieuwenhuizen N; Herbert DR; Lopata AL; Brombacher F. 2007. CD4+ T cell-specific deletion of IL-4 receptor alpha prevents ovalbumin-induced anaphylaxis by an IFN-gamma-dependent mechanism. J Immunol 179(5):2758-65. [PubMed: 17709489]  [MGI Ref ID J:151835]

Nishio M; Watanabe K; Sasaki J; Taya C; Takasuga S; Iizuka R; Balla T; Yamazaki M; Watanabe H; Itoh R; Kuroda S; Horie Y; Forster I; Mak TW; Yonekawa H; Penninger JM; Kanaho Y; Suzuki A; Sasaki T. 2007. Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1. Nat Cell Biol 9(1):36-44. [PubMed: 17173042]  [MGI Ref ID J:126426]

Odegaard JI; Ricardo-Gonzalez RR; Goforth MH; Morel CR; Subramanian V; Mukundan L; Eagle AR; Vats D; Brombacher F; Ferrante AW; Chawla A. 2007. Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature 447(7148):1116-20. [PubMed: 17515919]  [MGI Ref ID J:122754]

Ohtani M; Nagai S; Kondo S; Mizuno S; Nakamura K; Tanabe M; Takeuchi T; Matsuda S; Koyasu S. 2008. Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells. Blood 112(3):635-43. [PubMed: 18492954]  [MGI Ref ID J:138434]

Overton CD; Yancey PG; Major AS; Linton MF; Fazio S. 2007. Deletion of macrophage LDL receptor-related protein increases atherogenesis in the mouse. Circ Res 100(5):670-7. [PubMed: 17303763]  [MGI Ref ID J:133698]

Owen KA; Pixley FJ; Thomas KS; Vicente-Manzanares M; Ray BJ; Horwitz AF; Parsons JT; Beggs HE; Stanley ER; Bouton AH. 2007. Regulation of lamellipodial persistence, adhesion turnover, and motility in macrophages by focal adhesion kinase. J Cell Biol 179(6):1275-87. [PubMed: 18070912]  [MGI Ref ID J:135535]

Panopoulos AD; Zhang L; Snow JW; Jones DM; Smith AM; El Kasmi KC; Liu F; Goldsmith MA; Link DC; Murray PJ; Watowich SS. 2006. STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils. Blood 108(12):3682-90. [PubMed: 16888100]  [MGI Ref ID J:133477]

Park JM; Greten FR; Li ZW; Karin M. 2002. Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition. Science 297(5589):2048-51. [PubMed: 12202685]  [MGI Ref ID J:80159]

Park JM; Greten FR; Wong A; Westrick RJ; Arthur JS; Otsu K; Hoffmann A; Montminy M; Karin M. 2005. Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators. Immunity 23(3):319-29. [PubMed: 16169504]  [MGI Ref ID J:113273]

Park-Min KH; Serbina NV; Yang W; Ma X; Krystal G; Neel BG; Nutt SL; Hu X; Ivashkiv LB. 2007. FcgammaRIII-dependent inhibition of interferon-gamma responses mediates suppressive effects of intravenous immune globulin. Immunity 26(1):67-78. [PubMed: 17239631]  [MGI Ref ID J:118322]

Peng M; Falk MJ; Haase VH; King R; Polyak E; Selak M; Yudkoff M; Hancock WW; Meade R; Saiki R; Lunceford AL; Clarke CF; L Gasser D. 2008. Primary coenzyme Q deficiency in Pdss2 mutant mice causes isolated renal disease. PLoS Genet 4(4):e1000061. [PubMed: 18437205]  [MGI Ref ID J:136670]

Pestonjamasp KN; Forster C; Sun C; Gardiner EM; Bohl B; Weiner O; Bokoch GM; Glogauer M. 2006. Rac1 links leading edge and uropod events through Rho and myosin activation during chemotaxis. Blood 108(8):2814-20. [PubMed: 16809619]  [MGI Ref ID J:139459]

Peyssonnaux C; Cejudo-Martin P; Doedens A; Zinkernagel AS; Johnson RS; Nizet V. 2007. Cutting edge: Essential role of hypoxia inducible factor-1alpha in development of lipopolysaccharide-induced sepsis. J Immunol 178(12):7516-9. [PubMed: 17548584]  [MGI Ref ID J:148597]

Peyssonnaux C; Datta V; Cramer T; Doedens A; Theodorakis EA; Gallo RL; Hurtado-Ziola N; Nizet V; Johnson RS. 2005. HIF-1alpha expression regulates the bactericidal capacity of phagocytes. J Clin Invest 115(7):1806-15. [PubMed: 16007254]  [MGI Ref ID J:99628]

Prinz M; Schmidt H; Mildner A; Knobeloch KP; Hanisch UK; Raasch J; Merkler D; Detje C; Gutcher I; Mages J; Lang R; Martin R; Gold R; Becher B; Bruck W; Kalinke U. 2008. Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system. Immunity 28(5):675-86. [PubMed: 18424188]  [MGI Ref ID J:136301]

Rebholz B; Haase I; Eckelt B; Paxian S; Flaig MJ; Ghoreschi K; Nedospasov SA; Mailhammer R; Debey-Pascher S; Schultze JL; Weindl G; Forster I; Huss R; Stratis A; Ruzicka T; Rocken M; Pfeffer K; Schmid RM; Rupec RA. 2007. Crosstalk between Keratinocytes and Adaptive Immune Cells in an IkappaBalpha Protein-Mediated Inflammatory Disease of the Skin. Immunity 27(2):296-307. [PubMed: 17692539]  [MGI Ref ID J:124343]

Redecha P; Tilley R; Tencati M; Salmon JE; Kirchhofer D; Mackman N; Girardi G. 2007. Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody induced fetal injury. Blood 110(7):2423-31. [PubMed: 17536017]  [MGI Ref ID J:147022]

Reindl W; Weiss S; Lehr HA; Forster I. 2007. Essential crosstalk between myeloid and lymphoid cells for development of chronic colitis in myeloid-specific signal transducer and activator of transcription 3-deficient mice. Immunology 120(1):19-27. [PubMed: 17233738]  [MGI Ref ID J:122311]

Reutershan J; Cagnina RE; Chang D; Linden J; Ley K. 2007. Therapeutic anti-inflammatory effects of myeloid cell adenosine receptor A2a stimulation in lipopolysaccharide-induced lung injury. J Immunol 179(2):1254-63. [PubMed: 17617618]  [MGI Ref ID J:149341]

Rupec RA; Jundt F; Rebholz B; Eckelt B; Weindl G; Herzinger T; Flaig MJ; Moosmann S; Plewig G; Dorken B; Forster I; Huss R; Pfeffer K. 2005. Stroma-mediated dysregulation of myelopoiesis in mice lacking I kappa B alpha. Immunity 22(4):479-91. [PubMed: 15845452]  [MGI Ref ID J:97945]

Sabio G; Das M; Mora A; Zhang Z; Jun JY; Ko HJ; Barrett T; Kim JK; Davis RJ. 2008. A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science 322(5907):1539-43. [PubMed: 19056984]  [MGI Ref ID J:142035]

Sarraj B; Massberg S; Li Y; Kasorn A; Subramanian K; Loison F; Silberstein LE; von Andrian U; Luo HR. 2009. Myeloid-specific deletion of tumor suppressor PTEN augments neutrophil transendothelial migration during inflammation. J Immunol 182(11):7190-200. [PubMed: 19454716]  [MGI Ref ID J:148853]

Schabbauer G; Luyendyk J; Crozat K; Jiang Z; Mackman N; Bahram S; Georgel P. 2008. TLR4/CD14-mediated PI3K activation is an essential component of interferon-dependent VSV resistance in macrophages. Mol Immunol 45(10):2790-6. [PubMed: 18339426]  [MGI Ref ID J:134467]

Schaljo B; Kratochvill F; Gratz N; Sadzak I; Sauer I; Hammer M; Vogl C; Strobl B; Muller M; Blackshear PJ; Poli V; Lang R; Murray PJ; Kovarik P. 2009. Tristetraprolin is required for full anti-inflammatory response of murine macrophages to IL-10. J Immunol 183(2):1197-206. [PubMed: 19542371]  [MGI Ref ID J:151504]

Seimon TA; Obstfeld A; Moore KJ; Golenbock DT; Tabas I. 2006. Combinatorial pattern recognition receptor signaling alters the balance of life and death in macrophages. Proc Natl Acad Sci U S A 103(52):19794-9. [PubMed: 17167049]  [MGI Ref ID J:118240]

Seimon TA; Wang Y; Han S; Senokuchi T; Schrijvers DM; Kuriakose G; Tall AR; Tabas IA. 2009. Macrophage deficiency of p38alpha MAPK promotes apoptosis and plaque necrosis in advanced atherosclerotic lesions in mice. J Clin Invest 119(4):886-98. [PubMed: 19287091]  [MGI Ref ID J:149625]

Shah YM; Morimura K; Gonzalez FJ. 2007. Expression of peroxisome proliferator-activated receptor-gamma in macrophage suppresses experimentally induced colitis. Am J Physiol Gastrointest Liver Physiol 292(2):G657-66. [PubMed: 17095756]  [MGI Ref ID J:120606]

Siewe L; Bollati-Fogolin M; Wickenhauser C; Krieg T; Muller W; Roers A. 2006. Interleukin-10 derived from macrophages and/or neutrophils regulates the inflammatory response to LPS but not the response to CpG DNA. Eur J Immunol 36(12):3248-55. [PubMed: 17111348]  [MGI Ref ID J:117122]

Sinclair GB; Jevon G; Colobong KE; Randall DR; Choy FY; Clarke LA. 2007. Generation of a conditional knockout of murine glucocerebrosidase: Utility for the study of Gaucher disease. Mol Genet Metab 90(2):148-56. [PubMed: 17079175]  [MGI Ref ID J:117763]

Sinha P; Chi HH; Kim HR; Clausen BE; Pederson B; Sercarz EE; Forster I; Moudgil KD. 2004. Mouse lysozyme-M knockout mice reveal how the self-determinant hierarchy shapes the T cell repertoire against this circulating self antigen in wild-type mice. J Immunol 173(3):1763-71. [PubMed: 15265906]  [MGI Ref ID J:92024]

Sjogren AK; Andersson KM; Liu M; Cutts BA; Karlsson C; Wahlstrom AM; Dalin M; Weinbaum C; Casey PJ; Tarkowski A; Swolin B; Young SG; Bergo MO. 2007. GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer. J Clin Invest 117(5):1294-304. [PubMed: 17476360]  [MGI Ref ID J:122107]

Stadtfeld M; Graf T. 2005. Assessing the role of hematopoietic plasticity for endothelial and hepatocyte development by non-invasive lineage tracing. Development 132(1):203-13. [PubMed: 15576407]  [MGI Ref ID J:127936]

Stadtfeld M; Ye M; Graf T. 2007. Identification of interventricular septum precursor cells in the mouse embryo. Dev Biol 302(1):195-207. [PubMed: 17064678]  [MGI Ref ID J:119953]

Steimer DA; Boyd K; Takeuchi O; Fisher JK; Zambetti GP; Opferman JT. 2009. Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function. Blood 113(12):2805-15. [PubMed: 19064728]  [MGI Ref ID J:146310]

Stockmann C; Doedens A; Weidemann A; Zhang N; Takeda N; Greenberg JI; Cheresh DA; Johnson RS. 2008. Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis. Nature 456(7223):814-8. [PubMed: 18997773]  [MGI Ref ID J:143170]

Subramanian KK; Jia Y; Zhu D; Simms BT; Jo H; Hattori H; You J; Mizgerd JP; Luo HR. 2007. Tumor suppressor PTEN is a physiologic suppressor of chemoattractant-mediated neutrophil functions. Blood 109(9):4028-37. [PubMed: 17202315]  [MGI Ref ID J:145331]

Sun CX; Downey GP; Zhu F; Koh AL; Thang H; Glogauer M. 2004. Rac1 is the small GTPase responsible for regulating the neutrophil chemotaxis compass. Blood 104(12):3758-65. [PubMed: 15308574]  [MGI Ref ID J:94828]

Suzuki T; Kelly VP; Motohashi H; Nakajima O; Takahashi S; Nishimura S; Yamamoto M. 2008. Deletion of the selenocysteine tRNA gene in macrophages and liver results in compensatory gene induction of cytoprotective enzymes by Nrf2. J Biol Chem 283(4):2021-30. [PubMed: 18039655]  [MGI Ref ID J:130723]

Takeda K; Clausen BE; Kaisho T; Tsujimura T; Terada N; Forster I ; Akira S. 1999. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 10(1):39-49. [PubMed: 10023769]  [MGI Ref ID J:53681]

Tang X; Metzger D; Leeman S; Amar S. 2006. LPS-induced TNF-alpha factor (LITAF)-deficient mice express reduced LPS-induced cytokine: Evidence for LITAF-dependent LPS signaling pathways. Proc Natl Acad Sci U S A 103(37):13777-82. [PubMed: 16954198]  [MGI Ref ID J:113750]

Thorp E; Li Y; Bao L; Yao PM; Kuriakose G; Rong J; Fisher EA; Tabas I. 2009. Brief report: increased apoptosis in advanced atherosclerotic lesions of Apoe-/- mice lacking macrophage Bcl-2. Arterioscler Thromb Vasc Biol 29(2):169-72. [PubMed: 18988889]  [MGI Ref ID J:144243]

Tuckermann JP; Kleiman A; Moriggl R; Spanbroek R; Neumann A; Illing A; Clausen BE; Stride B; Forster I; Habenicht AJ; Reichardt HM; Tronche F; Schmid W; Schutz G. 2007. Macrophages and neutrophils are the targets for immune suppression by glucocorticoids in contact allergy. J Clin Invest 117(5):1381-90. [PubMed: 17446934]  [MGI Ref ID J:122112]

Tzima S; Victoratos P; Kranidioti K; Alexiou M; Kollias G. 2009. Myeloid heme oxygenase-1 regulates innate immunity and autoimmunity by modulating IFN-beta production. J Exp Med 206(5):1167-79. [PubMed: 19398754]  [MGI Ref ID J:148498]

Utomo A; Hirahashi J; Mekala D; Asano K; Glogauer M; Cullere X; Mayadas TN. 2008. Requirement for Vav proteins in post-recruitment neutrophil cytotoxicity in IgG but not complement C3-dependent injury. J Immunol 180(9):6279-87. [PubMed: 18424751]  [MGI Ref ID J:134524]

Valledor AF; Arpa L; Sanchez-Tillo E; Comalada M; Casals C; Xaus J; Caelles C; Lloberas J; Celada A. 2008. IFN-{gamma}-mediated inhibition of MAPK phosphatase expression results in prolonged MAPK activity in response to M-CSF and inhibition of proliferation. Blood 112(8):3274-82. [PubMed: 18682602]  [MGI Ref ID J:140209]

Valledor AF; Sanchez-Tillo E; Arpa L; Park JM; Caelles C; Lloberas J; Celada A. 2008. Selective Roles of MAPKs during the Macrophage Response to IFN-{gamma}. J Immunol 180(7):4523-9. [PubMed: 18354174]  [MGI Ref ID J:132992]

Vujic Spasic M; Kiss J; Herrmann T; Galy B; Martinache S; Stolte J; Grone HJ; Stremmel W; Hentze MW; Muckenthaler MU. 2008. Hfe acts in hepatocytes to prevent hemochromatosis. Cell Metab 7(2):173-8. [PubMed: 18249176]  [MGI Ref ID J:132134]

Wahlstrom AM; Cutts BA; Liu M; Lindskog A; Karlsson C; Sjogren AK; Andersson KM; Young SG; Bergo MO. 2008. Inactivating Icmt ameliorates K-RAS-induced myeloproliferative disease. Blood 112(4):1357-65. [PubMed: 18502828]  [MGI Ref ID J:138426]

Wang QQ; Li H; Oliver T; Glogauer M; Guo J; He YW. 2008. Integrin beta1 regulates phagosome maturation in macrophages through Rac expression. J Immunol 180(4):2419-28. [PubMed: 18250451]  [MGI Ref ID J:131992]

Wang Y; Lebowitz D; Sun C; Thang H; Grynpas MD; Glogauer M. 2008. Identifying the relative contributions of Rac1 and Rac2 to osteoclastogenesis. J Bone Miner Res 23(2):260-70. [PubMed: 17922611]  [MGI Ref ID J:145675]

Weischenfeldt J; Damgaard I; Bryder D; Theilgaard-Monch K; Thoren LA; Nielsen FC; Jacobsen SE; Nerlov C; Porse BT. 2008. NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements. Genes Dev 22(10):1381-96. [PubMed: 18483223]  [MGI Ref ID J:134765]

Wust S; van den Brandt J; Tischner D; Kleiman A; Tuckermann JP; Gold R; Luhder F; Reichardt HM. 2008. Peripheral T cells are the therapeutic targets of glucocorticoids in experimental autoimmune encephalomyelitis. J Immunol 180(12):8434-43. [PubMed: 18523311]  [MGI Ref ID J:137157]

Yamamoto M; Okamoto T; Takeda K; Sato S; Sanjo H; Uematsu S; Saitoh T; Yamamoto N; Sakurai H; Ishii KJ; Yamaoka S; Kawai T; Matsuura Y; Takeuchi O; Akira S. 2006. Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling. Nat Immunol 7(9):962-70. [PubMed: 16862162]  [MGI Ref ID J:112287]

Yang Y; Liu B; Dai J; Srivastava PK; Zammit DJ; Lefrancois L; Li Z. 2007. Heat Shock Protein gp96 Is a Master Chaperone for Toll-like Receptors and Is Important in the Innate Function of Macrophages. Immunity 26(2):215-26. [PubMed: 17275357]  [MGI Ref ID J:118427]

Yasukawa H; Ohishi M; Mori H; Murakami M; Chinen T; Aki D; Hanada T; Takeda K; Akira S; Hoshijima M; Hirano T; Chien KR; Yoshimura A. 2003. IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. Nat Immunol 4(6):551-6. [PubMed: 12754507]  [MGI Ref ID J:92040]

Zhang C; An J; Strickland DK; Yepes M. 2009. The low-density lipoprotein receptor-related protein 1 mediates tissue-type plasminogen activator-induced microglial activation in the ischemic brain. Am J Pathol 174(2):586-94. [PubMed: 19147818]  [MGI Ref ID J:144185]

Zhang D; Tang W; Yao PM; Yang C; Xie B; Jackowski S; Tabas I. 2000. Macrophages deficient in CTP:Phosphocholine cytidylyltransferase-alpha are viable under normal culture conditions but are highly susceptible to free cholesterol-induced death. MOLECULAR GENETIC EVIDENCE THAT THE INDUCTION OF PHOSPHATIDYLCHOLINE BIOSYNTHESIS IN FREE CHOLESTEROL-LOADED MACROPHAGES IS AN ADAPTIVE RESPONSE [In Process Citation] J Biol Chem 275(45):35368-76. [PubMed: 10944538]  [MGI Ref ID J:65639]

Zhang H; Sun C; Glogauer M; Bokoch GM. 2009. Human neutrophils coordinate chemotaxis by differential activation of Rac1 and Rac2. J Immunol 183(4):2718-28. [PubMed: 19625648]  [MGI Ref ID J:151789]

Zhao C; Irie N; Takada Y; Shimoda K; Miyamoto T; Nishiwaki T; Suda T; Matsuo K. 2006. Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis. Cell Metab 4(2):111-21. [PubMed: 16890539]  [MGI Ref ID J:129733]

Zhou J; Dehne N; Brune B. 2009. Nitric oxide causes macrophage migration via the HIF-1-stimulated small GTPases Cdc42 and Rac1. Free Radic Biol Med 47(6):741-9. [PubMed: 19523512]  [MGI Ref ID J:152571]

Zhu D; Hattori H; Jo H; Jia Y; Subramanian KK; Loison F; You J; Le Y; Honczarenko M; Silberstein L; Luo HR. 2006. Deactivation of phosphatidylinositol 3,4,5-trisphosphate/Akt signaling mediates neutrophil spontaneous death. Proc Natl Acad Sci U S A 103(40):14836-41. [PubMed: 16988010]  [MGI Ref ID J:114699]

Zhu X; Lee JY; Timmins JM; Brown JM; Boudyguina E; Mulya A; Gebre AK; Willingham MC; Hiltbold EM; Mishra N; Maeda N; Parks JS. 2008. Increased cellular free cholesterol in macrophage-specific Abca1 knock-out mice enhances pro-inflammatory response of macrophages. J Biol Chem 283(34):22930-41. [PubMed: 18552351]  [MGI Ref ID J:140263]

Zwaferink H; Stockinger S; Reipert S; Decker T. 2008. Stimulation of inducible nitric oxide synthase expression by beta interferon increases necrotic death of macrophages upon Listeria monocytogenes infection. Infect Immun 76(4):1649-56. [PubMed: 18268032]  [MGI Ref ID J:133523]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX12

Colony Maintenance

Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Diet Information LabDiet® 5K52/5K67

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations View International pricing
Weeks of AgePrice (US dollars $)GenderGenotypes Provided
Individual Mouse $107.90Female or MaleHomozygous for Lyz2tm1(cre)Ifo
Pairs /Price (US dollars $)Pair Genotype
$215.80Homozygous for Lyz2tm1(cre)Ifo x Homozygous for Lyz2tm1(cre)Ifo

Additional Supply Details

Pricing for International shipping destinations View USA Canada and Mexico pricing
Weeks of AgePrice (US dollars $)GenderGenotypes Provided
Individual Mouse $140.30Female or MaleHomozygous for Lyz2tm1(cre)Ifo
Pairs /Price (US dollars $)Pair Genotype
$280.60Homozygous for Lyz2tm1(cre)Ifo x Homozygous for Lyz2tm1(cre)Ifo

Additional Supply Details

Supply Details

Standard SupplyRepository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement.
Supply Notes

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
  International - Control Pricing Information for Genetically Engineered Mutant Strains.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering and Purchasing Information

      Purchasing Information
      JAX® Mice Orders
      Surgical Services

Contact Information
Orders & Technical Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.
- Use of MICE by companies or for-profit entities requires a license.

Contact information

General inquiries

Contracts Administration

phone:207-288-6470
fax:207-288-6655

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. In purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


(3.12)