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- Description
- Phenotype
- Genes & alleles
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Description
Strain Information
Former Names B6.129P2-Lyzstm1(cre)Ifo/J (Changed: 19-FEB-08 ) B6.129-Lyzstm1(cre)Ifo/J (Changed: 15-DEC-04 ) Type Congenic; Mutant Strain; Targeted Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Homozygote x Homozygote (Female x Male) 01-MAR-06 Species laboratory mouse Generation N6F?+F12 (30-DEC-08) Donating Investigator Irmgard Foerster, University of Duesseldorf Description
This strain expresses Cre recombinase from the endogenous Lyzs locus. When crossed with a strain containing loxP site flanked sequence of interest, Cre-mediated recombination results in deletion of the targeted gene in the myeloid cell lineage, including monocytes, mature macrophages, and granulocytes. Mice that are homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. This strain represents an effective tool for generating myeloid cell-specific targeted mutants.Development
A targeting vector containing a FRT-flanked neomycin resistance gene, herpes simplex virus thymidine kinase genes and NLS (nuclear localization signal) -Cre cDNA, was inserted into the endogenous ATG-start site within exon 1 of the Lyzs gene. The construct was electroporated into 129P2/OlaHsd-derived E14.1 embryonic stem (ES) cells. Correctly targeted ES cells were transiently transfected with a Flp expression vector for the purpose of removing the selectable marker cassette. ES cells that had successfully undergone Flp recombination were injected in blastocysts.
Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of cre
View Strains carrying other alleles of cre (162 strains)
Additional Web Information
Introduction to Cre-lox technology
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
cre relatedHematological Research
Hematopoietic Defects
Immunology and Inflammation Research
Autoimmunity
Immunodeficiency
Lymphoid Tissue Defects
hematopoietic development
Internal/Organ Research
Lymphoid Tissue Defects
Research Tools
Cre-lox System
Cre Recombinase Expression
Genetics Research
Tissue/Cell Markers: Cre-lox System
Immunology and Inflammation Research
Macrophage Deficiency
Lyz2tm1(cre)Ifo relatedResearch Tools
Cre-lox System
Developmental Biology Research
Internal/Organ Defects
Lymphoid Tissue Defects
Lymphoid Tissue Defects
hematopoietic defects
Hematological Research
Hematopoietic Defects
Immunological Defects
Neutrophil Defects
Immunology and Inflammation Research
Autoimmunity
experimentally induced rheumatoid arthritis
CD Antigens, Antigen Receptors, and Histocompatibility Markers
genes regulating susceptibility to infectious disease and endotoxin
Growth Factors/Receptors/Cytokines
Immunodeficiency
Neutrophil Defects
Inflammation
Neutrophil defects
Lymphoid Tissue Defects
hematopoietic development
Internal/Organ Research
Gastrointestinal Defects
Lymphoid Tissue Defects
Research Tools
Cancer Research
Leukemia
Cre-lox System
Cre Recombinase Expression
Genetics Research
Mutagenesis and Transgenesis: Cre-lox System
Hematological Research
Immunology and Inflammation Research
Macrophage Deficiency
genes regulating susceptibility to infectious disease and endotoxin
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Lyz2tm1(cre)Ifo | ||
|---|---|---|---|
| Allele Name | targeted mutation 1, Irmgard Foerster | ||
| Allele Type | Targeted (knock-in) | ||
| Common Name(s) | LC; Lys-cre; LysM Cre; LysM-Cre; LysMCre; LysMCre; Lystm1(cre)Ifo; lysM/cre; | ||
| Mutation Made By | Irmgard Foerster, University of Duesseldorf | ||
| Strain of Origin | 129P2/OlaHsd | ||
| ES Cell Line Name | E14 | ||
| ES Cell Line Strain | 129P2/OlaHsd | ||
| Site of Expression | myeloid cells - including monocytes, mature macrophages, and granulocytes | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Gene Symbol and Name | Lyz2, lysozyme 2 | ||
| Chromosome | 10 | ||
| Gene Common Name(s) | AI326280; LZM; Lys; Lysz; Lyz; Lyzs; Lzm-s1; Lzp; M lysozyme structural 1; expressed sequence AI326280; lysozyme; | ||
| Driver Note | Lyz2 | ||
| Molecular Note | An NLS-cre gene was inserted into the endogenous ATG start site of the gene. An frt-flanked neomycin cassette was removed in ES cells via Flp-mediated recombination prior to production of chimeric mice. [MGI Ref ID J:67924] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Lyz2tm1(cre)Ifo, Separated PCR
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Clausen BE; Burkhardt C; Reith W; Renkawitz R; Forster I. 1999. Conditional gene targeting in macrophages and granulocytes using LysMcre mice. Transgenic Res 8(4):265-77. [PubMed: 10621974] [MGI Ref ID J:67924]
Additional References
Takeda K; Clausen BE; Kaisho T; Tsujimura T; Terada N; Forster I ; Akira S. 1999. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 10(1):39-49. [PubMed: 10023769] [MGI Ref ID J:53681]
Lyz2tm1(cre)Ifo relatedAcharyya S; Villalta SA; Bakkar N; Bupha-Intr T; Janssen PM; Carathers M; Li ZW; Beg AA; Ghosh S; Sahenk Z; Weinstein M; Gardner KL; Rafael-Fortney JA; Karin M; Tidball JG; Baldwin AS; Guttridge DC. 2007. Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy. J Clin Invest 117(4):889-901. [PubMed: 17380205] [MGI Ref ID J:121279]
Aliprantis AO; Ueki Y; Sulyanto R; Park A; Sigrist KS; Sharma SM; Ostrowski MC; Olsen BR; Glimcher LH. 2008. NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism. J Clin Invest 118(11):3775-89. [PubMed: 18846253] [MGI Ref ID J:144598]
Babaev VR; Yancey PG; Ryzhov SV; Kon V; Breyer MD; Magnuson MA; Fazio S; Linton MF. 2005. Conditional knockout of macrophage PPARgamma increases atherosclerosis in C57BL/6 and low-density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol 25(8):1647-53. [PubMed: 15947238] [MGI Ref ID J:114332]
Bai S; Kopan R; Zou W; Hilton MJ; Ong CT; Long F; Ross FP; Teitelbaum SL. 2008. NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells. J Biol Chem 283(10):6509-18. [PubMed: 18156632] [MGI Ref ID J:133664]
Baumgartl J; Baudler S; Scherner M; Babaev V; Makowski L; Suttles J; McDuffie M; Tobe K; Kadowaki T; Fazio S; Kahn CR; Hotamisligil GS; Krone W; Linton M; Bruning JC. 2006. Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis. Cell Metab 3(4):247-56. [PubMed: 16581002] [MGI Ref ID J:129654]
Bayele HK; Peyssonnaux C; Giatromanolaki A; Arrais-Silva WW; Mohamed HS; Collins H; Giorgio S; Koukourakis M; Johnson RS; Blackwell JM; Nizet V; Srai SK. 2007. HIF-1 regulates heritable variation and allele expression phenotypes of the macrophage immune response gene SLC11A1 from a Z-DNA forming microsatellite. Blood 110(8):3039-48. [PubMed: 17606764] [MGI Ref ID J:148905]
Bhattacharjee G; Ahamed J; Pawlinski R; Liu C; Mackman N; Ruf W; Edgington TS. 2008. Factor Xa binding to annexin 2 mediates signal transduction via protease-activated receptor 1. Circ Res 102(4):457-64. [PubMed: 18174463] [MGI Ref ID J:147663]
Bhattacharyya S; Brown DE; Brewer JA; Vogt SK; Muglia LJ. 2007. Macrophage glucocorticoid receptors regulate Toll-like receptor 4-mediated inflammatory responses by selective inhibition of p38 MAP kinase. Blood 109(10):4313-9. [PubMed: 17255352] [MGI Ref ID J:141671]
Boesten LS; Zadelaar AS; van Nieuwkoop A; Hu L; Jonkers J; van de Water B; Gijbels MJ; van der Made I; de Winther MP; Havekes LM; van Vlijmen BJ. 2006. Macrophage retinoblastoma deficiency leads to enhanced atherosclerosis development in ApoE-deficient mice. FASEB J 20(7):953-5. [PubMed: 16585057] [MGI Ref ID J:111494]
Bogunovic M; Ginhoux F; Helft J; Shang L; Hashimoto D; Greter M; Liu K; Jakubzick C; Ingersoll MA; Leboeuf M; Stanley ER; Nussenzweig M; Lira SA; Randolph GJ; Merad M. 2009. Origin of the lamina propria dendritic cell network. Immunity 31(3):513-25. [PubMed: 19733489] [MGI Ref ID J:152688]
Bonfield TL; Thomassen MJ; Farver CF; Abraham S; Koloze MT; Zhang X; Mosser DM; Culver DA. 2008. Peroxisome proliferator-activated receptor-gamma regulates the expression of alveolar macrophage macrophage colony-stimulating factor. J Immunol 181(1):235-42. [PubMed: 18566389] [MGI Ref ID J:137408]
Bozec A; Bakiri L; Hoebertz A; Eferl R; Schilling AF; Komnenovic V; Scheuch H; Priemel M; Stewart CL; Amling M; Wagner EF. 2008. Osteoclast size is controlled by Fra-2 through LIF/LIF-receptor signalling and hypoxia. Nature 454(7201):221-5. [PubMed: 18548006] [MGI Ref ID J:137646]
Brydges SD; Mueller JL; McGeough MD; Pena CA; Misaghi A; Gandhi C; Putnam CD; Boyle DL; Firestein GS; Horner AA; Soroosh P; Watford WT; O'Shea JJ; Kastner DL; Hoffman HM. 2009. Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity. Immunity 30(6):875-87. [PubMed: 19501000] [MGI Ref ID J:150054]
Butcher BA; Kim L; Panopoulos AD; Watowich SS; Murray PJ; Denkers EY. 2005. IL-10-independent STAT3 activation by Toxoplasma gondii mediates suppression of IL-12 and TNF-alpha in host macrophages. J Immunol 174(6):3148-52. [PubMed: 15749841] [MGI Ref ID J:97691]
Caglayan E; Stauber B; Collins AR; Lyon CJ; Yin F; Liu J; Rosenkranz S; Erdmann E; Peterson LE; Ross RS; Tangirala RK; Hsueh WA. 2008. Differential roles of cardiomyocyte and macrophage peroxisome proliferator-activated receptor gamma in cardiac fibrosis. Diabetes 57(9):2470-9. [PubMed: 18511847] [MGI Ref ID J:141807]
Cao X; Wei G; Fang H; Guo J; Weinstein M; Marsh CB; Ostrowski MC; Tridandapani S. 2004. The inositol 3-phosphatase PTEN negatively regulates Fc gamma receptor signaling, but supports Toll-like receptor 4 signaling in murine peritoneal macrophages. J Immunol 172(8):4851-7. [PubMed: 15067063] [MGI Ref ID J:89105]
Cervantes-Barragan L; Kalinke U; Zust R; Konig M; Reizis B; Lopez-Macias C; Thiel V; Ludewig B. 2009. Type I IFN-mediated protection of macrophages and dendritic cells secures control of murine coronavirus infection. J Immunol 182(2):1099-106. [PubMed: 19124753] [MGI Ref ID J:143484]
Chong MM; Metcalf D; Jamieson E; Alexander WS; Kay TW. 2005. Suppressor of cytokine signaling-1 in T cells and macrophages is critical for preventing lethal inflammation. Blood 106(5):1668-75. [PubMed: 15899915] [MGI Ref ID J:118492]
Clemens RA; Lenox LE; Kambayashi T; Bezman N; Maltzman JS; Nichols KE; Koretzky GA. 2007. Loss of SLP-76 expression within myeloid cells confers resistance to neutrophil-mediated tissue damage while maintaining effective bacterial killing. J Immunol 178(7):4606-14. [PubMed: 17372019] [MGI Ref ID J:145136]
Corzo CA; Cotter MJ; Cheng P; Cheng F; Kusmartsev S; Sotomayor E; Padhya T; McCaffrey TV; McCaffrey JC; Gabrilovich DI. 2009. Mechanism regulating reactive oxygen species in tumor-induced myeloid-derived suppressor cells. J Immunol 182(9):5693-701. [PubMed: 19380816] [MGI Ref ID J:147709]
Cramer T; Yamanishi Y; Clausen BE; Forster I; Pawlinski R; Mackman N; Haase VH; Jaenisch R; Corr M; Nizet V; Firestein GS; Gerber HP; Ferrara N; Johnson RS. 2003. HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell 112(5):645-57. [PubMed: 12628185] [MGI Ref ID J:107682]
Cucak H; Yrlid U; Reizis B; Kalinke U; Johansson-Lindbom B. 2009. Type I interferon signaling in dendritic cells stimulates the development of lymph-node-resident T follicular helper cells. Immunity 31(3):491-501. [PubMed: 19733096] [MGI Ref ID J:152690]
Dzhagalov I; St John A; He YW. 2007. The antiapoptotic protein Mcl-1 is essential for the survival of neutrophils but not macrophages. Blood 109(4):1620-6. [PubMed: 17062731] [MGI Ref ID J:137502]
Eash KJ; Means JM; White DW; Link DC. 2009. CXCR4 is a key regulator of neutrophil release from the bone marrow under basal and stress granulopoiesis conditions. Blood 113(19):4711-9. [PubMed: 19264920] [MGI Ref ID J:150156]
El Kasmi KC; Holst J; Coffre M; Mielke L; de Pauw A; Lhocine N; Smith AM; Rutschman R; Kaushal D; Shen Y; Suda T; Donnelly RP; Myers MG Jr; Alexander W; Vignali DA; Watowich SS; Ernst M; Hilton DJ; Murray PJ. 2006. General nature of the STAT3-activated anti-inflammatory response. J Immunol 177(11):7880-8. [PubMed: 17114459] [MGI Ref ID J:140695]
El Kasmi KC; Qualls JE; Pesce JT; Smith AM; Thompson RW; Henao-Tamayo M; Basaraba RJ; Konig T; Schleicher U; Koo MS; Kaplan G; Fitzgerald KA; Tuomanen EI; Orme IM; Kanneganti TD; Bogdan C; Wynn TA; Murray PJ. 2008. Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens. Nat Immunol 9(12):1399-406. [PubMed: 18978793] [MGI Ref ID J:143229]
El Kasmi KC; Smith AM; Williams L; Neale G; Panopolous A; Watowich SS; Hacker H; Foxwell BM; Murray PJ. 2007. Cutting edge: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway. J Immunol 179(11):7215-9. [PubMed: 18025162] [MGI Ref ID J:133009]
Fong CH; Bebien M; Didierlaurent A; Nebauer R; Hussell T; Broide D; Karin M; Lawrence T. 2008. An antiinflammatory role for IKKbeta through the inhibition of 'classical' macrophage activation. J Exp Med 205(6):1269-76. [PubMed: 18490491] [MGI Ref ID J:137075]
Gallina G; Dolcetti L; Serafini P; De Santo C; Marigo I; Colombo MP; Basso G; Brombacher F; Borrello I; Zanovello P; Bicciato S; Bronte V. 2006. Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells. J Clin Invest 116(10):2777-90. [PubMed: 17016559] [MGI Ref ID J:114986]
Gaultier A; Arandjelovic S; Niessen S; Overton CD; Linton MF; Fazio S; Campana WM; Cravatt BF rd; Gonias SL. 2008. Regulation of tumor necrosis factor receptor-1 and the IKK-NF-kappaB pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor. Blood 111(11):5316-25. [PubMed: 18369152] [MGI Ref ID J:136163]
Glogauer M; Marchal CC; Zhu F; Worku A; Clausen BE; Foerster I; Marks P; Downey GP; Dinauer M; Kwiatkowski DJ. 2003. Rac1 deletion in mouse neutrophils has selective effects on neutrophil functions. J Immunol 170(11):5652-7. [PubMed: 12759446] [MGI Ref ID J:83457]
Goren I; Allmann N; Yogev N; Schurmann C; Linke A; Holdener M; Waisman A; Pfeilschifter J; Frank S. 2009. A transgenic mouse model of inducible macrophage depletion: effects of diphtheria toxin-driven lysozyme M-specific cell lineage ablation on wound inflammatory, angiogenic, and contractive processes. Am J Pathol 175(1):132-47. [PubMed: 19528348] [MGI Ref ID J:150035]
Greten FR; Arkan MC; Bollrath J; Hsu LC; Goode J; Miething C; Goktuna SI; Neuenhahn M; Fierer J; Paxian S; Van Rooijen N; Xu Y; O'Cain T; Jaffee BB; Busch DH; Duyster J; Schmid RM; Eckmann L; Karin M. 2007. NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta. Cell 130(5):918-31. [PubMed: 17803913] [MGI Ref ID J:129928]
Greten FR; Eckmann L; Greten TF; Park JM; Li ZW; Egan LJ; Kagnoff MF; Karin M. 2004. IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 118(3):285-96. [PubMed: 15294155] [MGI Ref ID J:91947]
Grivennikov SI; Tumanov AV; Liepinsh DJ; Kruglov AA; Marakusha BI; Shakhov AN; Murakami T; Drutskaya LN; Forster I; Clausen BE; Tessarollo L; Ryffel B; Kuprash DV; Nedospasov SA. 2005. Distinct and nonredundant in vivo functions of TNF produced by t cells and macrophages/neutrophils: protective and deleterious effects. Immunity 22(1):93-104. [PubMed: 15664162] [MGI Ref ID J:95684]
Hall AB; Gakidis MA; Glogauer M; Wilsbacher JL; Gao S; Swat W; Brugge JS. 2006. Requirements for Vav guanine nucleotide exchange factors and Rho GTPases in FcgammaR- and complement-mediated phagocytosis. Immunity 24(3):305-16. [PubMed: 16546099] [MGI Ref ID J:113323]
Hashimoto M; Ayada T; Kinjyo I; Hiwatashi K; Yoshida H; Okada Y; Kobayashi T; Yoshimura A. 2009. Silencing of SOCS1 in macrophages suppresses tumor development by enhancing antitumor inflammation. Cancer Sci 100(4):730-6. [PubMed: 19469017] [MGI Ref ID J:150670]
Hasselblatt P; Gresh L; Kudo H; Guinea-Viniegra J; Wagner EF. 2008. The role of the transcription factor AP-1 in colitis-associated and beta-catenin-dependent intestinal tumorigenesis in mice. Oncogene 27(47):6102-9. [PubMed: 18679426] [MGI Ref ID J:140139]
Herbert DR; Holscher C; Mohrs M; Arendse B; Schwegmann A; Radwanska M; Leeto M; Kirsch R; Hall P; Mossmann H; Claussen B; Forster I; Brombacher F. 2004. Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology. Immunity 20(5):623-35. [PubMed: 15142530] [MGI Ref ID J:114751]
Hevener AL; Olefsky JM; Reichart D; Nguyen MT; Bandyopadyhay G; Leung HY; Watt MJ; Benner C; Febbraio MA; Nguyen AK; Folian B; Subramaniam S; Gonzalez FJ; Glass CK; Ricote M. 2007. Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones. J Clin Invest 117(6):1658-69. [PubMed: 17525798] [MGI Ref ID J:122186]
Holscher C; Arendse B; Schwegmann A; Myburgh E; Brombacher F. 2006. Impairment of alternative macrophage activation delays cutaneous leishmaniasis in nonhealing BALB/c mice. J Immunol 176(2):1115-21. [PubMed: 16394000] [MGI Ref ID J:126442]
Horiguchi N; Wang L; Mukhopadhyay P; Park O; Jeong WI; Lafdil F; Osei-Hyiaman D; Moh A; Fu XY; Pacher P; Kunos G; Gao B. 2008. Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury. Gastroenterology 134(4):1148-58. [PubMed: 18395093] [MGI Ref ID J:136121]
Horiuchi K; Kimura T; Miyamoto T; Takaishi H; Okada Y; Toyama Y; Blobel CP. 2007. Cutting edge: TNF-alpha-converting enzyme (TACE/ADAM17) inactivation in mouse myeloid cells prevents lethality from endotoxin shock. J Immunol 179(5):2686-9. [PubMed: 17709479] [MGI Ref ID J:139846]
Hu L; Boesten LS; May P; Herz J; Bovenschen N; Huisman MV; Berbee JF; Havekes LM; van Vlijmen BJ; Tamsma JT. 2006. Macrophage low-density lipoprotein receptor-related protein deficiency enhances atherosclerosis in ApoE/LDLR double knockout mice. Arterioscler Thromb Vasc Biol 26(12):2710-5. [PubMed: 17038633] [MGI Ref ID J:129557]
Hu X; Chung AY; Wu I; Foldi J; Chen J; Ji JD; Tateya T; Kang YJ; Han J; Gessler M; Kageyama R; Ivashkiv LB. 2008. Integrated regulation of Toll-like receptor responses by Notch and interferon-gamma pathways. Immunity 29(5):691-703. [PubMed: 18976936] [MGI Ref ID J:143772]
Imai Y; Kuba K; Neely GG; Yaghubian-Malhami R; Perkmann T; van Loo G; Ermolaeva M; Veldhuizen R; Leung YH; Wang H; Liu H; Sun Y; Pasparakis M; Kopf M; Mech C; Bavari S; Peiris JS; Slutsky AS; Akira S; Hultqvist M; Holmdahl R; Nicholls J; Jiang C; Binder CJ; Penninger JM. 2008. Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell 133(2):235-49. [PubMed: 18423196] [MGI Ref ID J:145306]
Jakubzick C; Bogunovic M; Bonito AJ; Kuan EL; Merad M; Randolph GJ. 2008. Lymph-migrating, tissue-derived dendritic cells are minor constituents within steady-state lymph nodes. J Exp Med 205(12):2839-50. [PubMed: 18981237] [MGI Ref ID J:143220]
Jennewein C; Kuhn AM; Schmidt MV; Meilladec-Jullig V; von Knethen A; Gonzalez FJ; Brune B. 2008. Sumoylation of peroxisome proliferator-activated receptor gamma by apoptotic cells prevents lipopolysaccharide-induced NCoR removal from kappaB binding sites mediating transrepression of proinflammatory cytokines. J Immunol 181(8):5646-52. [PubMed: 18832723] [MGI Ref ID J:140756]
Johnnidis JB; Harris MH; Wheeler RT; Stehling-Sun S; Lam MH; Kirak O; Brummelkamp TR; Fleming MD; Camargo FD. 2008. Regulation of progenitor cell proliferation and granulocyte function by microRNA-223. Nature 451(7182):1125-9. [PubMed: 18278031] [MGI Ref ID J:140009]
Jude CD; Climer L; Xu D; Artinger E; Fisher JK; Ernst P. 2007. Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors. Cell Stem Cell 1(3):324-37. [PubMed: 18371366] [MGI Ref ID J:147265]
Kang K; Reilly SM; Karabacak V; Gangl MR; Fitzgerald K; Hatano B; Lee CH. 2008. Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity. Cell Metab 7(6):485-95. [PubMed: 18522830] [MGI Ref ID J:137033]
Kang TB; Ben-Moshe T; Varfolomeev EE; Pewzner-Jung Y; Yogev N; Jurewicz A; Waisman A; Brenner O; Haffner R; Gustafsson E; Ramakrishnan P; Lapidot T; Wallach D. 2004. Caspase-8 serves both apoptotic and nonapoptotic roles. J Immunol 173(5):2976-84. [PubMed: 15322156] [MGI Ref ID J:92722]
Kang YJ; Chen J; Otsuka M; Mols J; Ren S; Wang Y; Han J. 2008. Macrophage Deletion of p38{alpha} Partially Impairs Lipopolysaccharide-Induced Cellular Activation. J Immunol 180(7):5075-82. [PubMed: 18354233] [MGI Ref ID J:133368]
Kanters E; Pasparakis M; Gijbels MJ; Vergouwe MN; Partouns-Hendriks I; Fijneman RJ; Clausen BE; Forster I; Kockx MM; Rajewsky K; Kraal G; Hofker MH; de Winther MP. 2003. Inhibition of NF-kappaB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice. J Clin Invest 112(8):1176-85. [PubMed: 14561702] [MGI Ref ID J:86163]
Karlsson MC; Guinamard R; Bolland S; Sankala M; Steinman RM; Ravetch JV. 2003. Macrophages control the retention and trafficking of B lymphocytes in the splenic marginal zone. J Exp Med 198(2):333-40. [PubMed: 12874264] [MGI Ref ID J:119256]
Kasorn A; Alcaide P; Jia Y; Subramanian KK; Sarraj B; Li Y; Loison F; Hattori H; Silberstein LE; Luscinskas WF; Luo HR. 2009. Focal adhesion kinase regulates pathogen-killing capability and life span of neutrophils via mediating both adhesion-dependent and -independent cellular signals. J Immunol 183(2):1032-43. [PubMed: 19561112] [MGI Ref ID J:151655]
Kasper LH; Fukuyama T; Biesen MA; Boussouar F; Tong C; de Pauw A; Murray PJ; van Deursen JM; Brindle PK. 2006. Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development. Mol Cell Biol 26(3):789-809. [PubMed: 16428436] [MGI Ref ID J:105505]
Kenner L; Hoebertz A; Beil T; Keon N; Karreth F; Eferl R; Scheuch H; Szremska A; Amling M; Schorpp-Kistner M; Angel P; Wagner EF. 2004. Mice lacking JunB are osteopenic due to cell-autonomous osteoblast and osteoclast defects. J Cell Biol 164(4):613-23. [PubMed: 14769860] [MGI Ref ID J:88126]
Kim C; Sano Y; Todorova K; Carlson BA; Arpa L; Celada A; Lawrence T; Otsu K; Brissette JL; Arthur JS; Park JM. 2008. The kinase p38 alpha serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression. Nat Immunol 9(9):1019-27. [PubMed: 18677317] [MGI Ref ID J:140029]
Kimura A; Kinjyo I; Matsumura Y; Mori H; Mashima R; Harada M; Chien KR; Yasukawa H; Yoshimura A. 2004. SOCS3 is a physiological negative regulator for granulopoiesis and granulocyte colony-stimulating factor receptor signaling. J Biol Chem 279(8):6905-10. [PubMed: 14699146] [MGI Ref ID J:88961]
Kobayashi M; Kweon MN; Kuwata H; Schreiber RD; Kiyono H; Takeda K; Akira S. 2003. Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice. J Clin Invest 111(9):1297-308. [PubMed: 12727921] [MGI Ref ID J:83280]
Kontoyiannis D; Boulougouris G; Manoloukos M; Armaka M; Apostolaki M; Pizarro T; Kotlyarov A; Forster I; Flavell R; Gaestel M; Tsichlis P; Cominelli F; Kollias G. 2002. Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease. J Exp Med 196(12):1563-74. [PubMed: 12486099] [MGI Ref ID J:108572]
Kuroda S; Nishio M; Sasaki T; Horie Y; Kawahara K; Sasaki M; Natsui M; Matozaki T; Tezuka H; Ohteki T; Forster I; Mak TW; Nakano T; Suzuki A. 2008. Effective clearance of intracellular Leishmania major in vivo requires Pten in macrophages. Eur J Immunol 38(5):1331-40. [PubMed: 18398930] [MGI Ref ID J:133966]
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Lillis AP; Greenlee MC; Mikhailenko I; Pizzo SV; Tenner AJ; Strickland DK; Bohlson SS. 2008. Murine low-density lipoprotein receptor-related protein 1 (LRP) is required for phagocytosis of targets bearing LRP ligands but is not required for C1q-triggered enhancement of phagocytosis. J Immunol 181(1):364-73. [PubMed: 18566402] [MGI Ref ID J:137404]
Luyendyk JP; Schabbauer GA; Tencati M; Holscher T; Pawlinski R; Mackman N. 2008. Genetic Analysis of the Role of the PI3K-Akt Pathway in Lipopolysaccharide-Induced Cytokine and Tissue Factor Gene Expression in Monocytes/Macrophages. J Immunol 180(6):4218-26. [PubMed: 18322234] [MGI Ref ID J:132956]
Mabrouk I; Buart S; Hasmim M; Michiels C; Connault E; Opolon P; Chiocchia G; Levi-Strauss M; Chouaib S; Karray S. 2008. Prevention of autoimmunity and control of recall response to exogenous antigen by Fas death receptor ligand expression on T cells. Immunity 29(6):922-33. [PubMed: 19013083] [MGI Ref ID J:142793]
Maeda S; Kamata H; Luo JL; Leffert H; Karin M. 2005. IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 121(7):977-90. [PubMed: 15989949] [MGI Ref ID J:115107]
Magez S; Radwanska M; Drennan M; Fick L; Baral TN; Allie N; Jacobs M; Nedospasov S; Brombacher F; Ryffel B; De Baetselier P. 2007. Tumor necrosis factor (TNF) receptor-1 (TNFp55) signal transduction and macrophage-derived soluble TNF are crucial for nitric oxide-mediated Trypanosoma congolense parasite killing. J Infect Dis 196(6):954-62. [PubMed: 17703428] [MGI Ref ID J:145248]
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Milovanova TN; Bhopale VM; Sorokina EM; Moore JS; Hunt TK; Hauer-Jensen M; Velazquez OC; Thom SR. 2008. Lactate stimulates vasculogenic stem cells via the thioredoxin system and engages an autocrine activation loop involving hypoxia-inducible factor 1. Mol Cell Biol 28(20):6248-61. [PubMed: 18710947] [MGI Ref ID J:140963]
Necela BM; Su W; Thompson EA. 2008. Toll-like receptor 4 mediates cross-talk between peroxisome proliferator-activated receptor gamma and nuclear factor-kappaB in macrophages. Immunology 125(3):344-58. [PubMed: 18422969] [MGI Ref ID J:144451]
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Redecha P; Tilley R; Tencati M; Salmon JE; Kirchhofer D; Mackman N; Girardi G. 2007. Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody induced fetal injury. Blood 110(7):2423-31. [PubMed: 17536017] [MGI Ref ID J:147022]
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Sarraj B; Massberg S; Li Y; Kasorn A; Subramanian K; Loison F; Silberstein LE; von Andrian U; Luo HR. 2009. Myeloid-specific deletion of tumor suppressor PTEN augments neutrophil transendothelial migration during inflammation. J Immunol 182(11):7190-200. [PubMed: 19454716] [MGI Ref ID J:148853]
Schabbauer G; Luyendyk J; Crozat K; Jiang Z; Mackman N; Bahram S; Georgel P. 2008. TLR4/CD14-mediated PI3K activation is an essential component of interferon-dependent VSV resistance in macrophages. Mol Immunol 45(10):2790-6. [PubMed: 18339426] [MGI Ref ID J:134467]
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Seimon TA; Obstfeld A; Moore KJ; Golenbock DT; Tabas I. 2006. Combinatorial pattern recognition receptor signaling alters the balance of life and death in macrophages. Proc Natl Acad Sci U S A 103(52):19794-9. [PubMed: 17167049] [MGI Ref ID J:118240]
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Sinclair GB; Jevon G; Colobong KE; Randall DR; Choy FY; Clarke LA. 2007. Generation of a conditional knockout of murine glucocerebrosidase: Utility for the study of Gaucher disease. Mol Genet Metab 90(2):148-56. [PubMed: 17079175] [MGI Ref ID J:117763]
Sinha P; Chi HH; Kim HR; Clausen BE; Pederson B; Sercarz EE; Forster I; Moudgil KD. 2004. Mouse lysozyme-M knockout mice reveal how the self-determinant hierarchy shapes the T cell repertoire against this circulating self antigen in wild-type mice. J Immunol 173(3):1763-71. [PubMed: 15265906] [MGI Ref ID J:92024]
Sjogren AK; Andersson KM; Liu M; Cutts BA; Karlsson C; Wahlstrom AM; Dalin M; Weinbaum C; Casey PJ; Tarkowski A; Swolin B; Young SG; Bergo MO. 2007. GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer. J Clin Invest 117(5):1294-304. [PubMed: 17476360] [MGI Ref ID J:122107]
Stadtfeld M; Graf T. 2005. Assessing the role of hematopoietic plasticity for endothelial and hepatocyte development by non-invasive lineage tracing. Development 132(1):203-13. [PubMed: 15576407] [MGI Ref ID J:127936]
Stadtfeld M; Ye M; Graf T. 2007. Identification of interventricular septum precursor cells in the mouse embryo. Dev Biol 302(1):195-207. [PubMed: 17064678] [MGI Ref ID J:119953]
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Takeda K; Clausen BE; Kaisho T; Tsujimura T; Terada N; Forster I ; Akira S. 1999. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 10(1):39-49. [PubMed: 10023769] [MGI Ref ID J:53681]
Tang X; Metzger D; Leeman S; Amar S. 2006. LPS-induced TNF-alpha factor (LITAF)-deficient mice express reduced LPS-induced cytokine: Evidence for LITAF-dependent LPS signaling pathways. Proc Natl Acad Sci U S A 103(37):13777-82. [PubMed: 16954198] [MGI Ref ID J:113750]
Thorp E; Li Y; Bao L; Yao PM; Kuriakose G; Rong J; Fisher EA; Tabas I. 2009. Brief report: increased apoptosis in advanced atherosclerotic lesions of Apoe-/- mice lacking macrophage Bcl-2. Arterioscler Thromb Vasc Biol 29(2):169-72. [PubMed: 18988889] [MGI Ref ID J:144243]
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Tzima S; Victoratos P; Kranidioti K; Alexiou M; Kollias G. 2009. Myeloid heme oxygenase-1 regulates innate immunity and autoimmunity by modulating IFN-beta production. J Exp Med 206(5):1167-79. [PubMed: 19398754] [MGI Ref ID J:148498]
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Vujic Spasic M; Kiss J; Herrmann T; Galy B; Martinache S; Stolte J; Grone HJ; Stremmel W; Hentze MW; Muckenthaler MU. 2008. Hfe acts in hepatocytes to prevent hemochromatosis. Cell Metab 7(2):173-8. [PubMed: 18249176] [MGI Ref ID J:132134]
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Mating System Homozygote x Homozygote (Female x Male) 01-MAR-06 Diet Information LabDiet® 5K52/5K67
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Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $107.90 Female or Male Homozygous for Lyz2tm1(cre)Ifo
Pairs /Price (US dollars $) Pair Genotype $215.80 Homozygous for Lyz2tm1(cre)Ifo x Homozygous for Lyz2tm1(cre)Ifo
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Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $140.30 Female or Male Homozygous for Lyz2tm1(cre)Ifo
Pairs /Price (US dollars $) Pair Genotype $280.60 Homozygous for Lyz2tm1(cre)Ifo x Homozygous for Lyz2tm1(cre)Ifo
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| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement. |
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Terms of Use
Terms of Use
General Terms and Conditions
For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.
- Use of MICE by companies or for-profit entities requires a license.
Contact information
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| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. In purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.