Strain Name:

STOCK Tg(KRT14-cre)1Amc/J

Stock Number:

004782

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Availability:

Repository- Live

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The K14-Cre transgene has a human keratin 14 promoter directing expression of Cre recombinase. These K14-Cre transgenic mice are a Cre-lox tool useful for deletion of floxed sequences in the ectoderm and its derivatives (including the skin, dental epithelium, and oral ectoderm).

Description

Strain Information

Type Mutant Stock; Transgenic;
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Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Specieslaboratory mouse
Generation?+N1F22 (31-DEC-07)
Generation Definitions
 
Donating Investigator Andrew P McMahon,   University of Southern California

Description
Mice hemizygous for the K14-Cre transgene are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. These transgenic mice express Cre recombinase under the control of the human keratin 14 promoter. Cre transcript is detected in the skin. When crossed to a reporter line containing Gt(ROSA)26Sortm1Sor, Beta-galactosidase activity is detected in the oral ectoderm at 11.75 dpc, and at 14.5 dpc activity is detected in the skin and throughout the dental epithelium. This strain represents an effective tool for generating tissue-specific targeted mutants that would be useful to study developmentally critical gene function in the ectoderm and its derivatives.

View cre expression characterization.

Development
The K14-Cre transgene was designed with a human keratin 14 promoter/enhancer sequence, Cre recombinase gene, and the human growth hormone gene and polyadenylation signal. This transgene was introduced into B6CBAF1 donor eggs. The resulting transgenic founder animals were initially crossed to C57BL/6 mice, and then crossed to outbred Swiss Webster mice. Mice from two founder lines (199 and 200) were crossed with Shhn (null allele) mice for an unknown number of times. The Shhnallele was subsequently bred out of the The Jackson Laboratory Repository colony before 2005.

Control Information

  Control
   None Available
 
  Considerations for Choosing Controls

Related Strains

View Facebase: tools     (9 strains)

Strains carrying   Tg(KRT14-cre)1Amc allele
018964   B6N.Cg-Tg(KRT14-cre)1Amc/J
View Strains carrying   Tg(KRT14-cre)1Amc     (1 strain)

View Strains carrying other alleles of KRT14     (12 strains)

Strains carrying other alleles of cre
004337   129(Cg)-Foxg1tm1(cre)Skm/J
008569   129-Alpltm1(cre)Nagy/J
017611   129-Mcm2tm1(cre/ERT2)Scpr/J
005989   129;FVB-Tg(PTH-cre)4167Slib/J
007179   129S.Cg-Tg(UBC-cre/ERT2)1Ejb/J
007915   129S.FVB-Tg(Amh-cre)8815Reb/J
003328   129S/Sv-Tg(Prm-cre)58Og/J
026200   129S1.Cg-Tg(Vsx2-cre)2690Chow/J
004302   129S1/Sv-Hprttm1(cre)Mnn/J
022137   129S4.Cg-Tg(Wnt1-cre)2Sor/J
003960   129S6-Tg(Prnp-GFP/cre)1Blw/J
008523   129S6.Cg-Tg(NPHS2-cre)295Lbh/BroJ
009575   B6(129S4)-Et(cre/ERT2)119Rdav/J
009580   B6(129S4)-Et(cre/ERT2)1382Rdav/J
012688   B6(129S4)-Et(cre/ERT2)13866Rdav/J
009581   B6(129S4)-Et(cre/ERT2)1642Rdav/J
009582   B6(129S4)-Et(cre/ERT2)1645Rdav/J
009583   B6(129S4)-Et(cre/ERT2)1957Rdav/J
009584   B6(129S4)-Et(cre/ERT2)2007Rdav/J
009585   B6(129S4)-Et(cre/ERT2)2047Rdav/J
009574   B6(129S4)-Et(cre/ERT2)21Rdav/J
009577   B6(129S4)-Et(cre/ERT2)296Rdav/J
009578   B6(129S4)-Et(cre/ERT2)398Rdav/J
009573   B6(129S4)-Et(cre/ERT2)4Rdav/J
010688   B6(129S4)-Et(cre/ERT2)6691Rdav/J
010689   B6(129S4)-Et(cre/ERT2)6959Rdav/J
010690   B6(129S4)-Et(cre/ERT2)7089Rdav/J
010691   B6(129S4)-Et(cre/ERT2)7149Rdav/J
010692   B6(129S4)-Et(cre/ERT2)7381Rdav/J
010693   B6(129S4)-Et(cre/ERT2)8120Rdav/J
010694   B6(129S4)-Et(cre/ERT2)8131Rdav/J
009579   B6(129S4)-Et(cre/ERT2)837Rdav/J
010695   B6(129S4)-Et(cre/ERT2)9699Rdav/J
009587   B6(129S4)-Et(icre)1402Rdav/J
009588   B6(129S4)-Et(icre)1470Rdav/J
009589   B6(129S4)-Et(icre)1555Rdav/J
009586   B6(129S4)-Et(icre)754Rdav/J
010696   B6(129S4)-Et(icre/ERT2)10596Rdav/J
010697   B6(129S4)-Et(icre/ERT2)10727Rdav/J
012689   B6(129S4)-Et(icre/ERT2)14163Rdav/J
012690   B6(129S4)-Et(icre/ERT2)14208Rdav/J
012694   B6(129S4)-Et(icre/ERT2)14915Rdav/J
012687   B6(129S4)-Tg(SYN1-icre/mRFP1)9934Rdav/J
022356   B6(129X1)-Tg(Cd4-cre/ERT2)11Gnri/J
010774   B6(Cg)-Calb2tm1(cre)Zjh/J
013730   B6(Cg)-Calb2tm2.1(cre/ERT2)Zjh/J
017562   B6(Cg)-Cd8atm1.1(cre)Koni/J
012704   B6(Cg)-Crhtm1(cre)Zjh/J
010705   B6(Cg)-Dlx5tm1(cre/ERT2)Zjh/J
013048   B6(Cg)-Etv1tm1.1(cre/ERT2)Zjh/J
018448   B6(Cg)-Foxn1tm3(cre)Nrm/J
010776   B6(Cg)-Lhx6tm1(cre/ERT2)Zjh/J
010777   B6(Cg)-Pvalbtm1(cre/ERT2)Zjh/J
010708   B6(Cg)-Ssttm1(cre/ERT2)Zjh/J
016223   B6(Cg)-Tg(Phox2b-cre)3Jke/J
016829   B6(SJL)-Pou5f1tm1.1(cre/Esr1*)Yseg/J
021881   B6.129(Cg)-Arctm1.1(cre/ERT2)Luo/J
018867   B6.129(Cg)-Axin2tm1(cre/ERT2)Rnu/J
021882   B6.129(Cg)-Fostm1.1(cre/ERT2)Luo/J
016959   B6.129(Cg)-Foxp3tm4(YFP/cre)Ayr/J
023055   B6.129(Cg)-Krt12tm3(cre)Wwk/J
008463   B6.129-Gt(ROSA)26Sortm1(cre/ERT2)Tyj/J
008320   B6.129-Leprtm2(cre)Rck/J
017526   B6.129-Nos1tm1(cre)Mgmj/J
005697   B6.129-Otx1tm4(cre)Asim/J
018938   B6.129-Tac2tm1.1(cre)Qima/J
017769   B6.129-Trpv1tm1(cre)Bbm/J
004146   B6.129-Tg(Pcp2-cre)2Mpin/J
008710   B6.129P2(129S4)-Hprttm10(Ple162-EGFP/cre)Ems/Mmjax
008877   B6.129P2(129S4)-Hprttm12(Ple177-EGFP/cre)Ems/Mmjax
009116   B6.129P2(129S4)-Hprttm16(Ple167-EGFP/cre)Ems/Mmjax
008709   B6.129P2(129S4)-Hprttm9(Ple178-EGFP/cre)Ems/Mmjax
006785   B6.129P2(C)-Cd19tm1(cre)Cgn/J
021160   B6.129P2(Cg)-Cx3cr1tm2.1(cre/ERT)Litt/WganJ
006084   B6.129P2(Cg)-Foxg1tm1(cre)Skm/J
010611   B6.129P2(Cg)-Ighg1tm1(IRES-cre)Cgn/J
007770   B6.129P2-Aicdatm1(cre)Mnz/J
008875   B6.129P2-Lgr5tm1(cre/ERT2)Cle/J
016934   B6.129P2-Lgr6tm2.1(cre/ERT2)Cle/J
004781   B6.129P2-Lyz2tm1(cre)Ifo/J
017320   B6.129P2-Pvalbtm1(cre)Arbr/J
016222   B6.129S(Cg)-Id2tm1.1(cre/ERT2)Blh/ZhuJ
017915   B6.129S(Cg)-Pgrtm1.1(cre)Shah/AndJ
013594   B6.129S-Atoh1tm5.1(Cre/PGR)Hzo/J
021794   B6.129S1(Cg)-Ascl3tm1.1(EGFP/cre)Ovi/J
024637   B6.129S1(SJL)-Nkx2-5tm2(cre)Rph/J
006600   B6.129S1-Mnx1tm4(cre)Tmj/J
005628   B6.129S2-Emx1tm1(cre)Krj/J
022510   B6.129S4-Gpr88tm1.1(cre/GFP)Rpa/J
017578   B6.129S4-Mcpt8tm1(cre)Lky/J
003755   B6.129S4-Meox2tm1(cre)Sor/J
007893   B6.129S4-Myf5tm3(cre)Sor/J
005623   B6.129S6-Shhtm2(cre/ERT2)Cjt/J
006878   B6.129S6-Taglntm2(cre)Yec/J
012839   B6.129X1(Cg)-Tnfrsf4tm2(cre)Nik/J
008712   B6.129X1-Twist2tm1.1(cre)Dor/J
006054   B6.C-Tg(CMV-cre)1Cgn/J
020811   B6.C-Tg(Pgk1-cre)1Lni/CrsJ
019148   B6.Cg-Acantm1(cre/ERT2)Crm/J
023530   B6.Cg-Avptm1.1(cre)Hze/J
013590   B6.Cg-Braftm1Mmcm Ptentm1Hwu Tg(Tyr-cre/ERT2)13Bos/BosJ
023531   B6.Cg-Calb1tm1.1(folA/EGFP/cre)Hze/J
006230   B6.Cg-Cebpatm1Dgt Tg(Mx1-cre)1Cgn/J
012360   B6.Cg-Erbb4tm1.1(cre/ERT2)Aibs/J
023676   B6.Cg-Hprttm331(Ple275-icre/ERT2)Ems/Mmjax
023678   B6.Cg-Hprttm333(Ple281-icre/ERT2)Ems/Mmjax
023679   B6.Cg-Hprttm334(Ple279-icre/ERT2)Ems/Mmjax
023680   B6.Cg-Hprttm335(Ple277-icre/ERT2)Ems/Mmjax
023685   B6.Cg-Hprttm340(Ple252-icre/ERT2)Ems/Mmjax
023686   B6.Cg-Hprttm341(Ple273-icre/ERT2)Ems/Mmjax
023688   B6.Cg-Hprttm343(Ple270-icre/ERT2)Ems/Mmjax
022861   B6.Cg-Nxph4tm1.1(cre/ERT2)Hze/J
017763   B6.Cg-Pax7tm1(cre/ERT2)Gaka/J
022862   B6.Cg-Penktm1.1(cre/ERT2)Hze/J
012358   B6.Cg-Pvalbtm1.1(cre)Aibs/J
022863   B6.Cg-Pvalbtm5.1(cre/folA)Hze/J
005622   B6.Cg-Shhtm1(EGFP/cre)Cjt/J
022865   B6.Cg-Trib2tm1.1(cre/ERT2)Hze/J
022762   B6.Cg-Zfp335tm1.2Caw Emx1tm1(cre)Krj/J
017346   B6.Cg-Tg(A930038C07Rik-cre)1Aibs/J
006149   B6.Cg-Tg(ACTA1-cre)79Jme/J
003574   B6.Cg-Tg(Alb-cre)21Mgn/J
006881   B6.Cg-Tg(Aqp2-cre)1Dek/J
011104   B6.Cg-Tg(Atoh1-cre)1Bfri/J
004682   B6.Cg-Tg(CAG-cre/Esr1*)5Amc/J
008520   B6.Cg-Tg(CD2-cre)4Kio/J
009350   B6.Cg-Tg(CDX2-cre)101Erf/J
009352   B6.Cg-Tg(CDX2-cre*)189Erf/J
005359   B6.Cg-Tg(Camk2a-cre)T29-1Stl/J
022071   B6.Cg-Tg(Cd4-cre)1Cwi/BfluJ
012237   B6.Cg-Tg(Cdh16-cre)91Igr/J
016241   B6.Cg-Tg(Col1a1-cre/ERT2)1Crm/J
016237   B6.Cg-Tg(Col1a2-cre/ERT)7Cpd/J
006368   B6.Cg-Tg(Cr2-cre)3Cgn/J
008538   B6.Cg-Tg(Cspg4-cre/Esr1*)BAkik/J
006663   B6.Cg-Tg(Eno2-cre)39Jme/J
005069   B6.Cg-Tg(Fabp4-cre)1Rev/J
012712   B6.Cg-Tg(Fev-cre)1Esd/J
012849   B6.Cg-Tg(GFAP-cre/ERT2)505Fmv/J
012886   B6.Cg-Tg(Gfap-cre)73.12Mvs/J
024098   B6.Cg-Tg(Gfap-cre)77.6Mvs/2J
009642   B6.Cg-Tg(Gh1-cre)1Sac/J
024474   B6.Cg-Tg(Il9-cre)#Stck/J
003573   B6.Cg-Tg(Ins2-cre)25Mgn/J
008068   B6.Cg-Tg(Itgax-cre)1-1Reiz/J
008781   B6.Cg-Tg(Kap-cre)29066/2Sig/J
012837   B6.Cg-Tg(Lck-cre)3779Nik/J
003802   B6.Cg-Tg(Lck-cre)548Jxm/J
006889   B6.Cg-Tg(Lck-cre)I540Jxm/J
009643   B6.Cg-Tg(Lhb-cre)1Sac/J
008330   B6.Cg-Tg(Mc4r-cre)25Rck/J
003556   B6.Cg-Tg(Mx1-cre)1Cgn/J
007742   B6.Cg-Tg(Myh11-cre,-EGFP)2Mik/J
008205   B6.Cg-Tg(NPHS2-cre)295Lbh/J
003771   B6.Cg-Tg(Nes-cre)1Kln/J
010536   B6.Cg-Tg(Pcp2-cre)3555Jdhu/J
005975   B6.Cg-Tg(Plp1-cre/ERT)3Pop/J
008827   B6.Cg-Tg(Prdm1-cre)1Masu/J
005584   B6.Cg-Tg(Prrx1-cre)1Cjt/J
003967   B6.Cg-Tg(Rbp3-cre)528Jxm/J
021614   B6.Cg-Tg(S100A8-cre,-EGFP)1Ilw/J
008454   B6.Cg-Tg(Sox2-cre)1Amc/J
006361   B6.Cg-Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/J
003966   B6.Cg-Tg(Syn1-cre)671Jxm/J
017491   B6.Cg-Tg(Tagln-cre)1Her/J
004128   B6.Cg-Tg(Tek-cre)12Flv/J
008863   B6.Cg-Tg(Tek-cre)1Ywa/J
008601   B6.Cg-Tg(Th-cre)1Tmd/J
007606   B6.Cg-Tg(Thy1-cre/ERT2,-EYFP)AGfng/J
012328   B6.Cg-Tg(Tyr-cre/ERT2)13Bos/J
008085   B6.Cg-Tg(UBC-cre/ERT2)1Ejb/J
008610   B6.Cg-Tg(Vav1-cre)A2Kio/J
004586   B6.Cg-Tg(Vil-cre)997Gum/J
021504   B6.Cg-Tg(Vil1-cre)1000Gum/J
008735   B6.Cg-Tg(Wap-cre)11738Mam/JKnwJ
009614   B6.Cg-Tg(Wfs1-cre/ERT2)2Aibs/J
009107   B6.Cg-Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J
006234   B6.Cg-Tg(tetO-cre)1Jaw/J
016832   B6.FVB(129)-Tg(Alb1-cre)1Dlr/J
005657   B6.FVB(129)-Tg(Myh6-cre/Esr1*)1Jmk/J
024688   B6.FVB(129S)-Tg(Pax6-GFP/cre)1Rilm/J
006475   B6.FVB(129S4)-Tg(Ckmm-cre)5Khn/J
006451   B6.FVB(129X1)-Tg(Sim1-cre)1Lowl/J
006333   B6.FVB(Cg)-Tg(Neurog3-cre)C1Able/J
014643   B6.FVB-Tg(CMA1-cre)6Thhe/J
006137   B6.FVB-Tg(Cdh5-cre)7Mlia/J
018980   B6.FVB-Tg(Ddx4-cre)1Dcas/KnwJ
003724   B6.FVB-Tg(EIIa-cre)C5379Lmgd/J
011069   B6.FVB-Tg(Gh1-cre)bKnmn/J
011038   B6.FVB-Tg(Myh6-cre)2182Mds/J
014647   B6.FVB-Tg(Pdx1-cre)6Tuv/J
010714   B6.FVB-Tg(Pomc-cre)1Stl/J
022791   B6.FVB-Tg(Rorc-cre)1Litt/J
017535   B6.FVB-Tg(Slc32a1-cre)2.1Hzo/FrkJ
017490   B6.FVB-Tg(Stra8-cre)1Reb/LguJ
024670   B6.FVB-Tg(Ucp1-cre)1Evdr/J
003394   B6.FVB-Tg(Zp3-cre)3Mrt/J
006660   B6.SJL-Slc6a3tm1.1(cre)Bkmn/J
003552   B6129-Tg(Wap-cre)11738Mam/J
023161   B6129S-Tg(Foxp3-EGFP/cre)1aJbs/J
021961   B6;129-Abcg2tm3.1(cre/ERT2)Bsor/J
010531   B6;129-Bmi1tm1(cre/ERT)Mrc/J
008364   B6;129-Chattm1(cre/ERT)Nat/J
004847   B6;129-Gt(ROSA)26Sortm1(cre/ERT)Nat/J
021025   B6;129-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm1(tetO-cre)Haho/J
010557   B6;129-Gt(ROSA)26Sortm3(rtTA,tetO-cre/ERT)Nat/J
010529   B6;129-Myf5tm1(cre)Mrc/J
010528   B6;129-Myf6tm2(cre)Mrc/J
024475   B6;129-Myod1tm1.1(cre/ERT,TVA)Gcg/J
008363   B6;129-Nefltm1(cre/ERT)Nat/J
017525   B6;129-Ntstm1(cre)Mgmj/J
005549   B6;129-Pax3tm1(cre)Joe/J
012476   B6;129-Pax7tm2.1(cre/ERT2)Fan/J
009600   B6;129-Six2tm3(EGFP/cre/ERT2)Amc/J
008532   B6;129-Thtm1(cre/Esr1)Nat/J
008531   B6;129-Vamp2tm1(cre/ERT)Nat/J
017968   B6;129-Tg(Cdh5-cre)1Spe/J
024860   B6;129-Tg(Drd1-cre)120Mxu/Mmjax
010988   B6;129P-Cyp11a1tm1(GFP/cre)Pzg/J
010985   B6;129P-Klf3tm1(cre/ERT2)Pzg/J
008529   B6;129P-Tg(Neurog1-cre/ERT2)1Good/J
015854   B6;129P2-Foxl2tm1(GFP/cre/ERT2)Pzg/J
012601   B6;129P2-Lyve1tm1.1(EGFP/cre)Cys/J
006668   B6;129P2-Omptm4(cre)Mom/MomJ
008069   B6;129P2-Pvalbtm1(cre)Arbr/J
012373   B6;129S-Hoxb1tm1(cre)Og/J
014541   B6;129S-Nos1tm1.1(cre/ERT2)Zjh/J
024234   B6;129S-Oxttm1.1(cre)Dolsn/J
022864   B6;129S-Rasgrf2tm1(cre/folA)Hze/J
023526   B6;129S-Rorbtm1.1(cre)Hze/J
023527   B6;129S-Slc17a7tm1.1(cre)Hze/J
023525   B6;129S-Snap25tm2.1(cre)Hze/J
010987   B6;129S-Sox18tm1(GFP/cre/ERT2)Pzg/J
017593   B6;129S-Sox2tm1(cre/ERT2)Hoch/J
021877   B6;129S-Tac1tm1.1(cre)Hze/J
021878   B6;129S-Tac2tm1.1(cre)Hze/J
017685   B6;129S-Wisp3tm1(cre)Mawa/J
007001   B6;129S-Tg(UBC-cre/ERT2)1Ejb/J
009388   B6;129S1-Osr2tm2(cre)Jian/J
014551   B6;129S4-Dlx1tm1(cre/ERT2)Zjh/J
012463   B6;129S4-Foxd1tm1(GFP/cre)Amc/J
012464   B6;129S4-Foxd1tm2(GFP/cre/ERT2)Amc/J
011105   B6;129S4-Olig1tm1(cre)Rth/J
009576   B6;129S4-Et(cre/ERT2)278Rdav/J
006410   B6;129S6-Chattm2(cre)Lowl/J
024948   B6;129S6-Gdnftm1(cre/ERT2)Cos/J
012362   B6;129S6-Tg(Camk2a-cre/ERT2)1Aibs/J
017495   B6;129S7-Crim1tm1(GFP/cre/ERT2)Pzg/J
014638   B6;129X1-Cldn6tm1(cre/ERT2)Dam/J
009616   B6;C3-Tg(A930038C07Rik-cre)4Aibs/J
012433   B6;C3-Tg(ACTA1-rtTA,tetO-cre)102Monk/J
008844   B6;C3-Tg(Ctgf-cre)2Aibs/J
008839   B6;C3-Tg(Cyp39a1-cre)1Aibs/J
009117   B6;C3-Tg(Cyp39a1-cre)7Aibs/J
008848   B6;C3-Tg(Mybpc1-cre)2Aibs/J
009111   B6;C3-Tg(Scnn1a-cre)1Aibs/J
009112   B6;C3-Tg(Scnn1a-cre)2Aibs/J
009613   B6;C3-Tg(Scnn1a-cre)3Aibs/J
009103   B6;C3-Tg(Wfs1-cre/ERT2)3Aibs/J
025806   B6;CBA-Tg(Gsx2-cre)1Kess/J
025807   B6;CBA-Tg(Sox10-cre)1Wdr/J
024507   B6;CBA-Tg(Tbx21-cre)1Dlc/J
017494   B6;D-Tg(Tshz3-GFP/cre)43Amc/J
024926   B6;D2-Tg(Fshr-cre)1Ldu/J
003466   B6;D2-Tg(Sycp1-cre)4Min/J
014160   B6;DBA-Tg(S100b-EGFP/cre/ERT2)22Amc/J
014159   B6;DBA-Tg(Tmem100-EGFP/cre/ERT2)30Amc/J
015855   B6;DBA-Tg(Upk3a-GFP/cre/ERT2)26Amc/J
010803   B6;FVB-Tg(Adipoq-cre)1Evdr/J
018422   B6;FVB-Tg(Aicda-cre)1Rcas/J
023748   B6;FVB-Tg(Aldh1l1-cre)JD1884Gsat/J
011087   B6;FVB-Tg(Crh-cre)1Kres/J
008533   B6;FVB-Tg(Cspg4-cre)1Akik/J
003734   B6;FVB-Tg(GZMB-cre)1Jcb/J
004426   B6;SJL-Tg(Cga-cre)3Sac/J
003554   B6;SJL-Tg(Col2a1-cre)1Bhr/J
017738   B6;SJL-Tg(Foxl1-cre)1Khk/J
005249   B6;SJL-Tg(Krt1-15-cre/PGR)22Cot/J
007610   B6;SJL-Tg(Thy1-cre/ERT2,-EYFP)VGfng/J
007252   B6Ei.129S4-Tg(Prm-cre)58Og/EiJ
018956   B6N.129P2(B6)-Lyz2tm1(cre)Ifo/J
018958   B6N.129P2-Cd19tm1(cre)Cgn/J
021077   B6N.129S1-Mrgprb4tm3(cre)And/J
018957   B6N.129S6(B6)-Chattm2(cre)Lowl/J
017911   B6N.129S6(Cg)-Esr1tm1.1(cre)And/J
019013   B6N.129S6(Cg)-Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
016225   B6N.129S6(Cg)-Scgb1a1tm1(cre/ERT)Blh/J
018974   B6N.B6-Tg(Nr4a1-EGFP/cre)820Khog/J
019021   B6N.Cg-Ccktm1.1(cre)Zjh/J
019022   B6N.Cg-Gad2tm2(cre)Zjh/J
018973   B6N.Cg-Ssttm2.1(cre)Zjh/J
018961   B6N.Cg-Tg(Alb-cre)21Mgn/J
019102   B6N.Cg-Tg(CAG-cre/Esr1*)5Amc/CjDswJ
018966   B6N.Cg-Tg(Camk2a-cre)T29-1Stl/J
018965   B6N.Cg-Tg(Fabp4-cre)1Rev/J
017310   B6N.Cg-Tg(Hsd17b1-icre/ERT2)3Casa/J
018960   B6N.Cg-Tg(Ins2-cre)25Mgn/J
018967   B6N.Cg-Tg(Itgax-cre)1-1Reiz/J
019103   B6N.Cg-Tg(Nes-cre)1Kln/CjDswJ
014094   B6N.Cg-Tg(Sox2-cre)1Amc/J
018968   B6N.Cg-Tg(Vav1-cre)A2Kio/J
018963   B6N.Cg-Tg(Vil-cre)997Gum/J
018972   B6N.FVB(B6)-Tg(Myh6-cre)2182Mds/J
019099   B6N.FVB-Tg(ACTB-cre)2Mrt/CjDswJ
019509   B6N.FVB-Tg(BGLAP-cre)1Clem/J
023047   B6N.FVB-Tg(Dmp1-cre)1Jqfe/BwdJ
017927   B6N.FVB-Tg(Mpz-cre)26Mes/J
010550   B6N.FVB-Tg(Penk-glc-2-cre/ERT2)2And/J
017743   B6N;129S-Prom1tm1(cre/ERT2)Gilb/J
003465   BALB/c-Tg(CMV-cre)1Cgn/J
012641   BALB/c-Tg(S100a4-cre)1Egn/YunkJ
010612   C.129P2(Cg)-Ighg1tm1(IRES-cre)Cgn/J
017353   C.129S4(B6)-Il13tm1(YFP/cre)Lky/J
017582   C.129S4(B6)-Mcpt8tm1(cre)Lky/J
004126   C.Cg-Cd19tm1(cre)Cgn Ighb/J
005673   C.Cg-Tg(Mx1-cre)1Cgn/J
006244   C.Cg-Tg(tetO-cre)1Jaw/J
009155   C57BL/6-Cldn6tm1(cre)Dkwu/J
017557   C57BL/6-Tg(BEST1-cre)1Jdun/J
016097   C57BL/6-Tg(Car1-cre)5Flt/J
011086   C57BL/6-Tg(Cck-cre)CKres/J
008766   C57BL/6-Tg(Cd8a-cre)1Itan/J
006474   C57BL/6-Tg(Grik4-cre)G32-4Stl/J
008314   C57BL/6-Tg(HBB-cre)12Kpe/J
008870   C57BL/6-Tg(Hspa2-cre)1Eddy/J
016261   C57BL/6-Tg(Nes-cre/ERT2)KEisc/J
012906   C57BL/6-Tg(Nes-cre/Esr1*)1Kuan/J
016617   C57BL/6-Tg(Nr4a1-EGFP/cre)820Khog/J
020287   C57BL/6-Tg(Pbsn-cre/Esr1*)14Abch/J
013148   C57BL/6-Tg(Pdgfra-cre)1Clc/J
008535   C57BL/6-Tg(Pf4-cre)Q3Rsko/J
024034   C57BL/6-Tg(Pmch-cre)1Rck/J
016583   C57BL/6-Tg(Slc6a3-icre/ERT2)2Gloss/J
006888   C57BL/6-Tg(Zp3-cre)1Gwh/J
003651   C57BL/6-Tg(Zp3-cre)93Knw/J
021119   C57BL/6J-Tg(Dlx2-cre,-mCherry)4Grsr/GrsrJ
021423   C57BL/6J-Tg(Dlx2-cre,-mCherry)9Grsr/GrsrJ
007567   C57BL/6J-Tg(Itgax-cre,-EGFP)4097Ach/J
018895   C57BL/6J-Tg(Krt6,-cre,-Cerulean)1Grsr/Grsr
018896   C57BL/6J-Tg(Krt6,-cre,-Cerulean)2Grsr/Grsr
018898   C57BL/6J-Tg(Krt6,-cre,-Cerulean)4Grsr/Grsr
018899   C57BL/6J-Tg(Krt6,-cre,-Cerulean)5Grsr/Grsr
021582   C57BL/6J-Tg(Mchr1-cre)1Emf/J
008661   C57BL/6J-Tg(Nkx2-1-cre)2Sand/J
018754   C57BL/6J-Tg(Tbx22,-cre,-mCherry)1Grsr/GrsrJ
019363   C57BL/6J-Tg(Trp63,-cre,-Cerulean)10Grsr/Grsr
018792   C57BL/6J-Tg(Trp63,-cre,-Cerulean)4Grsr/GrsrJ
003650   C57BL/6J-Tg(Zp3-cre)82Knw/KnwJ
018151   C57BL/6N-Krt17tm1(cre,Cerulean)Murr/GrsrJ
023014   C57BL/6N-Tg(Calcrl,cre)4688Nkza/J
012686   C57BL/6N-Tg(Ppp1r2-cre)4127Nkza/J
016582   C57BL/6N-Tg(Slc32a1-icre/ERT2)3Gloss/J
026266   D2.B6-Tg(Zp3-cre)93Knw/SjJ
024701   D2.Cg-Tg(Plp1-cre/ERT)3Pop/SjJ
016833   FVB(Cg)-Tg(Alb1-cre)1Dlr/J
012929   FVB(Cg)-Tg(Dhh-cre)1Mejr/J
011034   FVB(Cg)-Tg(Ghrhr-cre)3242Lsk/J
023407   FVB-HhatTg(TFAP2A-cre)1Will/J
006405   FVB-Tg(Ckmm-cre)5Khn/J
006774   FVB-Tg(Col2a1-cre/ERT)KA3Smac/J
021024   FVB-Tg(Csf1r-icre)1Jwp/J
006954   FVB-Tg(Ddx4-cre)1Dcas/J
004600   FVB-Tg(GFAP-cre)25Mes/J
011037   FVB-Tg(Myh6-cre)2182Mds/J
006364   FVB-Tg(Nr5a1-cre)2Lowl/J
008537   FVB-Tg(Tek-cre)2352Rwng/J
019382   FVB.Cg-Myh9tm1.1Gac Tg(NPHS2-cre)295Lbh/Mmjax
014140   FVB.Cg-Myod1tm2.1(icre)Glh/J
006139   FVB.Cg-Tg(ACTA1-cre)79Jme/J
017595   FVB.Cg-Tg(CAG-cre/Esr1*)5Amc/J
006297   FVB.Cg-Tg(Eno2-cre)39Jme/J
018394   FVB.Cg-Tg(KRT5-cre/ERT2)2Ipc/JeldJ
008244   FVB.Cg-Tg(tetO-cre)1Jaw/J
003376   FVB/N-Tg(ACTB-cre)2Mrt/J
024384   FVB/N-Tg(AMELX-cre)A1Kul/J
003314   FVB/N-Tg(EIIa-cre)C5379Lmgd/J
017928   FVB/N-Tg(Mpz-cre)26Mes/J
006143   FVB/N-Tg(Thy1-cre)1Vln/J
003377   FVB/N-Tg(Zp3-cre)3Mrt/J
023325   FVB;B6-Tg(Pbsn-cre)20Fwan/J
019096   NOD.129P2(B6)-Lyz2tm1(cre)Ifo/NadlJ
023806   NOD.129P2(Cg)-Cd19tm1(cre)Cgn/J
013233   NOD.B6-Tg(Itgax-cre,-EGFP)4097Ach/J
013234   NOD.Cg-Tg(Cd4-cre)1Cwi/2AchJ
023972   NOD.Cg-Tg(Ins2-cre/ERT)1Dam/SbwJ
023203   NOD.Cg-Tg(Itgax-cre)1-1Reiz/PesaJ
005732   NOD.Cg-Tg(Lck-cre)548Jxm/AchJ
023973   NOD.Cg-Tg(Neurog3-cre)1Dam/SbwJ
013251   NOD.FVB-Tg(EIIa-cre)C5379Lmgd/J
008694   NOD/ShiLt-Tg(Foxp3-EGFP/cre)1cJbs/J
004986   NOD/ShiLt-Tg(Ins2-cre)3Lt/LtJ
003855   NOD/ShiLt-Tg(Ins2-cre)5Lt/LtJ
004987   NOD/ShiLt-Tg(Ins2-cre)6Lt/LtJ
012899   STOCK Agrptm1(cre)Lowl/J
012882   STOCK Ascl1tm1.1(Cre/ERT2)Jejo/J
012706   STOCK Ccktm1.1(cre)Zjh/J
012710   STOCK Ccktm2.1(cre/ERT2)Zjh/J
010910   STOCK Corttm1(cre)Zjh/J
007916   STOCK En1tm2(cre)Wrst/J
007917   STOCK En1tm7(cre/ESR1)Alj/J
007924   STOCK En2tm4(cre/ERT2)Alj/J
008464   STOCK Foxa2tm2.1(cre/Esr1*)Moon/J
016961   STOCK Foxp3tm9(EGFP/cre/ERT2)Ayr/J
010702   STOCK Gad2tm1(cre/ERT2)Zjh/J
010802   STOCK Gad2tm2(cre)Zjh/J
022135   STOCK Gbx2tm1.1(cre/ERT2)Jyhl/J
007913   STOCK Gli1tm3(cre/ERT2)Alj/J
018903   STOCK Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
024283   STOCK Hcn4tm2.1(cre/ERT2)Sev/J
017606   STOCK Hopxtm2.1(cre/ERT2)Joe/J
008876   STOCK Hprttm11(Ple176-EGFP/cre)Ems/Mmjax
016879   STOCK Il17atm1.1(icre)Stck/J
024242   STOCK Isl1tm1(cre)Sev/J
018976   STOCK Kdrtm1(cre)Sato/J
017701   STOCK Kiss1tm1.1(cre/EGFP)Stei/J
018418   STOCK Lrig1tm1.1(cre/ERT2)Rjc/J
007022   STOCK Mnx1tm4(cre)Tmj Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
004192   STOCK Mttptm2Sgy Ldlrtm1Her Apobtm2Sgy Tg(Mx1-cre)1Cgn/J
023342   STOCK Myf5tm1(cre/Esr1*)Trdo/J
024713   STOCK Myl1tm1(cre)Sjb/J
014180   STOCK Myocdtm1(cre)Jomm/J
014552   STOCK Nkx2-1tm1.1(cre/ERT2)Zjh/J
017536   STOCK Nkx6-2tm1(cre/ERT2)Fsh/J
006953   STOCK Notch1tm3(cre)Rko/J
006677   STOCK Olfr151tm28(cre)Mom/MomJ
011103   STOCK Olig2tm2(TVA,cre)Rth/J
009061   STOCK Osr1tm1(EGFP/cre/ERT2)Amc/J
010530   STOCK Pax7tm1(cre)Mrc/J
017569   STOCK Polr2atm1(cre/ERT2)Bbd E4f1tm1.1Llca/J
017585   STOCK Polr2atm1(cre/ERT2)Bbd/J
022757   STOCK Prg4tm1(GFP/cre/ERT2)Abl/J
019378   STOCK Ptf1atm2(cre/ESR1)Cvw/J
016963   STOCK Slc17a6tm2(cre)Lowl/J
016962   STOCK Slc32a1tm2(cre)Lowl/J
013044   STOCK Ssttm2.1(cre)Zjh/J
012719   STOCK Tgfb3tm1(cre)Vk/J
012620   STOCK Trp53tm1Brd Brca1tm1Aash Tg(LGB-cre)74Acl/J
008813   STOCK Trpa1tm2Kykw Tg(CAG-cre/Esr1*)5Amc/J
010908   STOCK Viptm1(cre)Zjh/J
010911   STOCK Wt1tm1(EGFP/cre)Wtp/J
010912   STOCK Wt1tm2(cre/ERT2)Wtp/J
012691   STOCK Et(icre/ERT2)14374Rdav/J
012692   STOCK Et(icre/ERT2)14602Rdav/J
012693   STOCK Et(icre/ERT2)14624Rdav/J
007684   STOCK Tg(Atoh1-cre/Esr1*)14Fsh/J
008783   STOCK Tg(CAG-cre/Esr1*)5Amc Smn1tm3(SMN2/Smn1)Mrph Tg(SMN2*delta7)4299Ahmb Tg(SMN2)89Ahmb/J
004453   STOCK Tg(CAG-cre/Esr1*)5Amc/J
009615   STOCK Tg(Cartpt-cre)1Aibs/J
017336   STOCK Tg(Cd4-cre)1Cwi/BfluJ
005105   STOCK Tg(Chx10-EGFP/cre,-ALPP)2Clc/J
008861   STOCK Tg(Ela1-Cre/ERT2)1Stof/J
008852   STOCK Tg(En2-cre)22Alj/J
005938   STOCK Tg(Eno2-cre)39Jme/J
022763   STOCK Tg(Eno2-cre/ERT2)1Pohlk/J
011062   STOCK Tg(Gdf9-cre)5092Coo/J
012841   STOCK Tg(Ggt1-cre)M3Egn/J
021207   STOCK Tg(Gnrh1-cre)1Dlc/J
017981   STOCK Tg(Hoxb6-cre)#Mku/J
004692   STOCK Tg(Hoxb7-cre)13Amc/J
014600   STOCK Tg(I12b-cre/ERT2,-ALPP)37Fsh/J
008122   STOCK Tg(Ins2-cre/ERT)1Dam/J
005107   STOCK Tg(KRT14-cre/ERT)20Efu/J
008582   STOCK Tg(Kcnc2-Cre)K128Stl/LetJ
023426   STOCK Tg(Kiss1-cre)J2-4Cfe/J
017836   STOCK Tg(LGB-cre)74Acl/J
003551   STOCK Tg(MMTV-cre)1Mam/J
003553   STOCK Tg(MMTV-cre)4Mam/J
002527   STOCK Tg(Mx1-cre)1Cgn/J
009074   STOCK Tg(Myh6-cre)1Jmk/J
005650   STOCK Tg(Myh6-cre/Esr1*)1Jmk/J
009102   STOCK Tg(Nefh-cre)12Kul/J
002858   STOCK Tg(Nes-cre)1Wme/J
002859   STOCK Tg(Nes-cre)2Wme/J
012859   STOCK Tg(Neurog1-cre)1Jejo/J
005667   STOCK Tg(Neurog3-cre)C1Able/J
008119   STOCK Tg(Neurog3-cre/Esr1*)1Dam/J
012462   STOCK Tg(Nr5a1-cre)7Lowl/J
014158   STOCK Tg(Pax4-cre)1Dam/J
024578   STOCK Tg(Pax6-GFP/cre)1Rilm/J
006207   STOCK Tg(Pcp2-cre)1Amc/J
014099   STOCK Tg(Pmch-cre)1Lowl/J
005965   STOCK Tg(Pomc1-cre)16Lowl/J
012452   STOCK Tg(Rr5-GFP/cre)1Sapc/J
006395   STOCK Tg(Sim1-cre)1Lowl/J
009606   STOCK Tg(Six2-EGFP/cre)1Amc/J
018147   STOCK Tg(Slc17a8-icre)1Edw/SealJ
012586   STOCK Tg(Slc1a3-cre/ERT)1Nat/J
004783   STOCK Tg(Sox2-cre)1Amc/J
008208   STOCK Tg(Stra8-cre)1Reb/J
016236   STOCK Tg(TCF/Lef1-cre/ERT2)1Dje/J
004746   STOCK Tg(Tagln-cre)1Her/J
012708   STOCK Tg(Thy1-cre/ERT2,-EYFP)HGfng/PyngJ
024240   STOCK Tg(Tnnt2-cre)5Blh/JiaoJ
016584   STOCK Tg(Tph2-icre/ERT2)6Gloss/J
003829   STOCK Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J
008851   STOCK Tg(Wnt1-cre/ERT)1Alj/J
018281   STOCK Tg(Wnt7a-EGFP/cre)#Bhr/Mmjax
008199   STOCK Tg(dlx6a-cre)1Mekk/J
002471   STOCK Tg(hCMV-cre)140Sau/J
023724   STOCK Tg(mI56i-cre,EGFP)1Kc/J
006224   STOCK Tg(tetO-cre)1Jaw/J
View Strains carrying other alleles of cre     (501 strains)

Additional Web Information

Introduction to Cre-lox technology

Phenotype

Phenotype Information

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Cancer Research
Cre-lox System
      Cre recombinase expression

Developmental Biology Research
Craniofacial and Palate Defects
      Orofacial clefting-specific cre expression

Research Tools
Cancer Research
      Cre-lox System
Cre-lox System
      Cre Recombinase Expression
Developmental Biology Research
      Cre-lox System
Genetics Research
      Mutagenesis and Transgenesis
      Mutagenesis and Transgenesis: Cre-lox System
      Tissue/Cell Markers: Cre-lox System

cre related

Research Tools
Cre-lox System
Genetics Research
      Mutagenesis and Transgenesis
      Mutagenesis and Transgenesis: Cre-lox System

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Tg(KRT14-cre)1Amc
Allele Name transgene insertion 1, Andrew P McMahon
Allele Type Transgenic (Recombinase (cre or Flp) expressing)
Common Name(s) K14 cre; K14-cre; K14cre; Krt14Cre;
Mutation Made By Joe Vaughan,   Harvard University
Strain of Origin(C57BL/6 x CBA)F1
Site of Expressionskin, the oral ectoderm including the dental lamina at 11.75 d.p.c., and the dental epithelium by 14.5 d.p.c.
Expressed Gene cre, cre recombinase, bacteriophage P1
Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence.
Promoter KRT14, keratin 14, human
Driver Note KRT14
General Note This allele is representative of 2 founders (#199 and #200) exhibiting the highest level of transgene expression.

Hemizygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities.

Molecular Note The transgene is composed of a cre recombinase gene under the control of a human keratin 14 promoter. The human KRT14 promoter directs transgene expression in hair and skin. The transgene also contains a human growth hormone sequence and polyadenylationsignal. When crossed to a transgenic reporter line, beta-galactosidase activity was detected in the oral ectoderm at 11.75 dpc, and at 14.5 dpc activity is detected in the skin and throughout the dental epithelium. [MGI Ref ID J:65294]
 
 

Genotyping

Genotyping Information

Genotyping Protocols

Generic Cre Quantitative PCR, QPCR
Generic Cre, Standard PCR
Tg(KRT14-cre)1Amc, Melt Curve Analysis
Tg(KRT14-cre)1Amc, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Dassule HR; Lewis P; Bei M; Maas R; McMahon AP. 2000. Sonic hedgehog regulates growth and morphogenesis of the tooth Development 127(22):4775-85. [PubMed: 11044393]  [MGI Ref ID J:65294]

Additional References

Tg(KRT14-cre)1Amc related

Ahn Y; Sanderson BW; Klein OD; Krumlauf R. 2010. Inhibition of Wnt signaling by Wise (Sostdc1) and negative feedback from Shh controls tooth number and patterning. Development 137(19):3221-31. [PubMed: 20724449]  [MGI Ref ID J:168361]

Ahn Y; Sims C; Logue JM; Weatherbee SD; Krumlauf R. 2013. Lrp4 and Wise interplay controls the formation and patterning of mammary and other skin appendage placodes by modulating Wnt signaling. Development 140(3):583-93. [PubMed: 23293290]  [MGI Ref ID J:194074]

Azarova AM; Lyu YL; Lin CP; Tsai YC; Lau JY; Wang JC; Liu LF. 2007. From the Cover: Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies. Proc Natl Acad Sci U S A 104(26):11014-9. [PubMed: 17578914]  [MGI Ref ID J:125761]

Bardot ES; Valdes VJ; Zhang J; Perdigoto CN; Nicolis S; Hearn SA; Silva JM; Ezhkova E. 2013. Polycomb subunits Ezh1 and Ezh2 regulate the Merkel cell differentiation program in skin stem cells. EMBO J 32(14):1990-2000. [PubMed: 23673358]  [MGI Ref ID J:198919]

Blanco S; Kurowski A; Nichols J; Watt FM; Benitah SA; Frye M. 2011. The RNA-methyltransferase Misu (NSun2) poises epidermal stem cells to differentiate. PLoS Genet 7(12):e1002403. [PubMed: 22144916]  [MGI Ref ID J:179810]

Bojovic B; Ho HY; Wu J; Crowe DL. 2013. Stem cell expansion during carcinogenesis in stem cell-depleted conditional telomeric repeat factor 2 null mutant mice. Oncogene 32(43):5156-66. [PubMed: 23178498]  [MGI Ref ID J:203237]

Bowman-Colin C; Xia B; Bunting S; Klijn C; Drost R; Bouwman P; Fineman L; Chen X; Culhane AC; Cai H; Rodig SJ; Bronson RT; Jonkers J; Nussenzweig A; Kanellopoulou C; Livingston DM. 2013. Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer. Proc Natl Acad Sci U S A 110(21):8632-7. [PubMed: 23657012]  [MGI Ref ID J:197442]

Breart B; Ramos-Perez WD; Mendoza A; Salous AK; Gobert M; Huang Y; Adams RH; Lafaille JJ; Escalante-Alcalde D; Morris AJ; Schwab SR. 2011. Lipid phosphate phosphatase 3 enables efficient thymic egress. J Exp Med 208(6):1267-78. [PubMed: 21576386]  [MGI Ref ID J:176831]

Caffarel MM; Zaragoza R; Pensa S; Li J; Green AR; Watson CJ. 2012. Constitutive activation of JAK2 in mammary epithelium elevates Stat5 signalling, promotes alveologenesis and resistance to cell death, and contributes to tumourigenesis. Cell Death Differ 19(3):511-22. [PubMed: 21941370]  [MGI Ref ID J:203080]

Cang Y; Zhang J; Nicholas SA; Kim AL; Zhou P; Goff SP. 2007. DDB1 is essential for genomic stability in developing epidermis. Proc Natl Acad Sci U S A 104(8):2733-7. [PubMed: 17301228]  [MGI Ref ID J:125911]

Chakrabarti R; Hwang J; Andres Blanco M; Wei Y; Lukacisin M; Romano RA; Smalley K; Liu S; Yang Q; Ibrahim T; Mercatali L; Amadori D; Haffty BG; Sinha S; Kang Y. 2012. Elf5 inhibits the epithelial-mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2. Nat Cell Biol 14(11):1212-22. [PubMed: 23086238]  [MGI Ref ID J:194019]

Chakrabarti R; Wei Y; Romano RA; DeCoste C; Kang Y; Sinha S. 2012. Elf5 regulates mammary gland stem/progenitor cell fate by influencing notch signaling. Stem Cells 30(7):1496-508. [PubMed: 22523003]  [MGI Ref ID J:194574]

Chen D; Jarrell A; Guo C; Lang R; Atit R. 2012. Dermal beta-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation. Development 139(8):1522-33. [PubMed: 22434869]  [MGI Ref ID J:183485]

Chen J; Den Z; Koch PJ. 2008. Loss of desmocollin 3 in mice leads to epidermal blistering. J Cell Sci 121(Pt 17):2844-9. [PubMed: 18682494]  [MGI Ref ID J:140129]

Cheng X; Jin J; Hu L; Shen D; Dong XP; Samie MA; Knoff J; Eisinger B; Liu ML; Huang SM; Caterina MJ; Dempsey P; Michael LE; Dlugosz AA; Andrews NC; Clapham DE; Xu H. 2010. TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation. Cell 141(2):331-43. [PubMed: 20403327]  [MGI Ref ID J:164741]

Choi YI; Duke-Cohan JS; Tan J; Gui J; Singh MK; Epstein JA; Reinherz EL. 2013. Plxnd1 expression in thymocytes regulates their intrathymic migration while that in thymic endothelium impacts medullary topology. Front Immunol 4:392. [PubMed: 24312099]  [MGI Ref ID J:206838]

Choi YS; Chakrabarti R; Escamilla-Hernandez R; Sinha S. 2009. Elf5 conditional knockout mice reveal its role as a master regulator in mammary alveolar development: failure of Stat5 activation and functional differentiation in the absence of Elf5. Dev Biol 329(2):227-41. [PubMed: 19269284]  [MGI Ref ID J:148362]

Croyle MJ; Lehman JM; O'Connor AK; Wong SY; Malarkey EB; Iribarne D; Dowdle WE; Schoeb TR; Verney ZM; Athar M; Michaud EJ; Reiter JF; Yoder BK. 2011. Role of epidermal primary cilia in the homeostasis of skin and hair follicles. Development 138(9):1675-85. [PubMed: 21429982]  [MGI Ref ID J:171221]

Cui CY; Childress V; Piao Y; Michel M; Johnson AA; Kunisada M; Ko MS; Kaestner KH; Marmorstein AD; Schlessinger D. 2012. Forkhead transcription factor FoxA1 regulates sweat secretion through Bestrophin 2 anion channel and Na-K-Cl cotransporter 1. Proc Natl Acad Sci U S A :. [PubMed: 22223659]  [MGI Ref ID J:179924]

Dai D; Li L; Huebner A; Zeng H; Guevara E; Claypool DJ; Liu A; Chen J. 2013. Planar cell polarity effector gene Intu regulates cell fate-specific differentiation of keratinocytes through the primary cilia. Cell Death Differ 20(1):130-8. [PubMed: 22935613]  [MGI Ref ID J:205544]

Donati G; Proserpio V; Lichtenberger BM; Natsuga K; Sinclair R; Fujiwara H; Watt FM. 2014. Epidermal Wnt/beta-catenin signaling regulates adipocyte differentiation via secretion of adipogenic factors. Proc Natl Acad Sci U S A 111(15):E1501-9. [PubMed: 24706781]  [MGI Ref ID J:208878]

Driskell I; Oda H; Blanco S; Nascimento E; Humphreys P; Frye M. 2012. The histone methyltransferase Setd8 acts in concert with c-Myc and is required to maintain skin. EMBO J 31(3):616-29. [PubMed: 22117221]  [MGI Ref ID J:181779]

Economou AD; Ohazama A; Porntaveetus T; Sharpe PT; Kondo S; Basson MA; Gritli-Linde A; Cobourne MT; Green JB. 2012. Periodic stripe formation by a Turing mechanism operating at growth zones in the mammalian palate. Nat Genet 44(3):348-51. [PubMed: 22344222]  [MGI Ref ID J:181644]

Egawa G; Osawa M; Uemura A; Miyachi Y; Nishikawa S. 2009. Transient expression of ephrin b2 in perinatal skin is required for maintenance of keratinocyte homeostasis. J Invest Dermatol 129(10):2386-95. [PubMed: 19571816]  [MGI Ref ID J:157054]

Evers BM; Farooqi MS; Shelton JM; Richardson JA; Goldstein JL; Brown MS; Liang G. 2010. Hair growth defects in Insig-deficient mice caused by cholesterol precursor accumulation and reversed by simvastatin. J Invest Dermatol 130(5):1237-48. [PubMed: 20090767]  [MGI Ref ID J:159927]

Fell GL; Robinson KC; Mao J; Woolf CJ; Fisher DE. 2014. Skin beta-endorphin mediates addiction to UV light. Cell 157(7):1527-34. [PubMed: 24949966]  [MGI Ref ID J:214436]

Flowers MT; Paton CM; O'Byrne SM; Schiesser K; Dawson JA; Blaner WS; Kendziorski C; Ntambi JM. 2011. Metabolic changes in skin caused by scd1 deficiency: a focus on retinol metabolism. PLoS One 6(5):e19734. [PubMed: 21573029]  [MGI Ref ID J:172432]

Foijer F; DiTommaso T; Donati G; Hautaviita K; Xie SZ; Heath E; Smyth I; Watt FM; Sorger PK; Bradley A. 2013. Spindle checkpoint deficiency is tolerated by murine epidermal cells but not hair follicle stem cells. Proc Natl Acad Sci U S A 110(8):2928-33. [PubMed: 23382243]  [MGI Ref ID J:194539]

Franzke CW; Cobzaru C; Triantafyllopoulou A; Loffek S; Horiuchi K; Threadgill DW; Kurz T; van Rooijen N; Bruckner-Tuderman L; Blobel CP. 2012. Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation. J Exp Med 209(6):1105-19. [PubMed: 22565824]  [MGI Ref ID J:189051]

Funato N; Nakamura M; Richardson JA; Srivastava D; Yanagisawa H. 2012. Tbx1 regulates oral epithelial adhesion and palatal development. Hum Mol Genet 21(11):2524-37. [PubMed: 22371266]  [MGI Ref ID J:183770]

Genetic Resource Science at The Jackson Laboratory. 2012. Expression/Specificity Patterns of Cre Alleles, 2012 MGI Direct Data Submission :.  [MGI Ref ID J:184579]

Genetic Resource Science at The Jackson Laboratory. 2008. Expression/Specificity patterns of Cre transgenes MGI Direct Data Submission :.  [MGI Ref ID J:137887]

Gonzalez-Gonzalez E; Ra H; Hickerson RP; Wang Q; Piyawattanametha W; Mandella MJ; Kino GS; Leake D; Avilion AA; Solgaard O; Doyle TC; Contag CH; Kaspar RL. 2009. siRNA silencing of keratinocyte-specific GFP expression in a transgenic mouse skin model. Gene Ther 16(8):963-72. [PubMed: 19474811]  [MGI Ref ID J:173006]

Gritli-Linde A; Bei M; Maas R; Zhang XM; Linde A; McMahon AP. 2002. Shh signaling within the dental epithelium is necessary for cell proliferation, growth and polarization. Development 129(23):5323-37. [PubMed: 12403705]  [MGI Ref ID J:80081]

Gritli-Linde A; Hallberg K; Harfe BD; Reyahi A; Kannius-Janson M; Nilsson J; Cobourne MT; Sharpe PT; McMahon AP; Linde A. 2007. Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling. Dev Cell 12(1):99-112. [PubMed: 17199044]  [MGI Ref ID J:117334]

Groot AJ; Cobzaru C; Weber S; Saftig P; Blobel CP; Kopan R; Vooijs M; Franzke CW. 2013. Epidermal ADAM17 Is Dispensable for Notch Activation. J Invest Dermatol 133(9):2286-8. [PubMed: 23657465]  [MGI Ref ID J:200543]

Guo J; Feng Y; Barnes P; Huang FF; Idell S; Su DM; Shams H. 2012. Deletion of FoxN1 in the thymic medullary epithelium reduces peripheral T cell responses to infection and mimics changes of aging. PLoS One 7(4):e34681. [PubMed: 22514652]  [MGI Ref ID J:187080]

Guo J; Rahman M; Cheng L; Zhang S; Tvinnereim A; Su DM. 2011. Morphogenesis and maintenance of the 3D thymic medulla and prevention of nude skin phenotype require FoxN1 in pre- and post-natal K14 epithelium. J Mol Med (Berl) 89(3):263-77. [PubMed: 21109991]  [MGI Ref ID J:187504]

Hamanaka RB; Glasauer A; Hoover P; Yang S; Blatt H; Mullen AR; Getsios S; Gottardi CJ; DeBerardinis RJ; Lavker RM; Chandel NS. 2013. Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development. Sci Signal 6(261):ra8. [PubMed: 23386745]  [MGI Ref ID J:213840]

Huh SH; Narhi K; Lindfors PH; Haara O; Yang L; Ornitz DM; Mikkola ML. 2013. Fgf20 governs formation of primary and secondary dermal condensations in developing hair follicles. Genes Dev 27(4):450-8. [PubMed: 23431057]  [MGI Ref ID J:193958]

Ishikawa TO; Herschman HR. 2010. Conditional Bicistronic Cre Reporter Line Expressing Both Firefly Luciferase and beta-galactosidase. Mol Imaging Biol :. [PubMed: 20495880]  [MGI Ref ID J:165837]

Jiao J; Mikulec C; Ishikawa TO; Magyar C; Dumlao DS; Dennis EA; Fischer SM; Herschman H. 2014. Cell-type-specific roles for COX-2 in UVB-induced skin cancer. Carcinogenesis 35(6):1310-9. [PubMed: 24469308]  [MGI Ref ID J:211594]

Kanemaru K; Nakamura Y; Sato K; Kojima R; Takahashi S; Yamaguchi M; Ichinohe M; Kiyonari H; Shioi G; Kabashima K; Nakahigashi K; Asagiri M; Jamora C; Yamaguchi H; Fukami K. 2012. Epidermal phospholipase Cdelta1 regulates granulocyte counts and systemic interleukin-17 levels in mice. Nat Commun 3:963. [PubMed: 22805570]  [MGI Ref ID J:205633]

Klein OD; Lyons DB; Balooch G; Marshall GW; Basson MA; Peterka M; Boran T; Peterkova R; Martin GR. 2008. An FGF signaling loop sustains the generation of differentiated progeny from stem cells in mouse incisors. Development 135(2):377-85. [PubMed: 18077585]  [MGI Ref ID J:130572]

Kurosaka H; Islam MN; Kuremoto K; Hayano S; Nakamura M; Kawanabe N; Yanagita T; Rice DP; Harada H; Taniuchi I; Yamashiro T. 2011. Core binding factor beta functions in the maintenance of stem cells and orchestrates continuous proliferation and differentiation in mouse incisors. Stem Cells 29(11):1792-803. [PubMed: 21898689]  [MGI Ref ID J:190203]

Kyrylkova K; Kyryachenko S; Biehs B; Klein O; Kioussi C; Leid M. 2012. BCL11B regulates epithelial proliferation and asymmetric development of the mouse mandibular incisor. PLoS One 7(5):e37670. [PubMed: 22629441]  [MGI Ref ID J:187316]

Landrette SF; Cornett JC; Ni TK; Bosenberg MW; Xu T. 2011. piggyBac transposon somatic mutagenesis with an activated reporter and tracker (PB-SMART) for genetic screens in mice. PLoS One 6(10):e26650. [PubMed: 22039523]  [MGI Ref ID J:179725]

Larrieu-Lahargue F; Welm AL; Thomas KR; Li DY. 2010. Netrin-4 induces lymphangiogenesis in vivo. Blood 115(26):5418-26. [PubMed: 20407033]  [MGI Ref ID J:162807]

Lee DW; Zhao X; Yim YI; Eisenberg E; Greene LE. 2008. Essential role of cyclin-G-associated kinase (Auxilin-2) in developing and mature mice. Mol Biol Cell 19(7):2766-76. [PubMed: 18434600]  [MGI Ref ID J:180119]

Lee R; Chang SY; Trinh H; Tu Y; White AC; Davies BS; Bergo MO; Fong LG; Lowry WE; Young SG. 2010. Genetic studies on the functional relevance of the protein prenyltransferases in skin keratinocytes. Hum Mol Genet 19(8):1603-17. [PubMed: 20106865]  [MGI Ref ID J:158528]

Lee TC; Threadgill DW. 2009. Generation and validation of mice carrying a conditional allele of the epidermal growth factor receptor. Genesis 47(2):85-92. [PubMed: 19115345]  [MGI Ref ID J:145161]

Leishman E; Howard JM; Garcia GE; Miao Q; Ku AT; Dekker JD; Tucker H; Nguyen H. 2013. Foxp1 maintains hair follicle stem cell quiescence through regulation of Fgf18. Development 140(18):3809-18. [PubMed: 23946441]  [MGI Ref ID J:204447]

Leonoudakis D; Singh M; Mohajer R; Mohajer P; Fata JE; Campbell KP; Muschler JL. 2010. Dystroglycan controls signaling of multiple hormones through modulation of STAT5 activity. J Cell Sci 123(Pt 21):3683-92. [PubMed: 20940259]  [MGI Ref ID J:182923]

Longmate WM; Monichan R; Chu ML; Tsuda T; Mahoney MG; DiPersio CM. 2014. Reduced fibulin-2 contributes to loss of basement membrane integrity and skin blistering in mice lacking integrin alpha3beta1 in the epidermis. J Invest Dermatol 134(6):1609-17. [PubMed: 24390135]  [MGI Ref ID J:210857]

Lu H; Lu Q; Zheng Y; Li Q. 2012. Notch signaling promotes the corneal epithelium wound healing. Mol Vis 18:403-11. [PubMed: 22355251]  [MGI Ref ID J:191494]

Ma L; Lopez GF; Krimm RF. 2009. Epithelial-derived brain-derived neurotrophic factor is required for gustatory neuron targeting during a critical developmental period. J Neurosci 29(11):3354-64. [PubMed: 19295142]  [MGI Ref ID J:147048]

Maklad A; Nicolai JR; Bichsel KJ; Evenson JE; Lee TC; Threadgill DW; Hansen LA. 2009. The EGFR is required for proper innervation to the skin. J Invest Dermatol 129(3):690-8. [PubMed: 18830272]  [MGI Ref ID J:145069]

Maksimovic S; Nakatani M; Baba Y; Nelson AM; Marshall KL; Wellnitz SA; Firozi P; Woo SH; Ranade S; Patapoutian A; Lumpkin EA. 2014. Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors. Nature 509(7502):617-21. [PubMed: 24717432]  [MGI Ref ID J:213252]

Maricich SM; Morrison KM; Mathes EL; Brewer BM. 2012. Rodents rely on Merkel cells for texture discrimination tasks. J Neurosci 32(10):3296-300. [PubMed: 22399751]  [MGI Ref ID J:182735]

McFarlane MR; Liang G; Engelking LJ. 2014. Insig proteins mediate feedback inhibition of cholesterol synthesis in the intestine. J Biol Chem 289(4):2148-56. [PubMed: 24337570]  [MGI Ref ID J:209522]

Medvetz DA; Khabibullin D; Hariharan V; Ongusaha PP; Goncharova EA; Schlechter T; Darling TN; Hofmann I; Krymskaya VP; Liao JK; Huang H; Henske EP. 2012. Folliculin, the product of the Birt-Hogg-Dube tumor suppressor gene, interacts with the adherens junction protein p0071 to regulate cell-cell adhesion. PLoS One 7(11):e47842. [PubMed: 23139756]  [MGI Ref ID J:195594]

Meng L; Lin T; Peng G; Hsu JK; Lee S; Lin SY; Tsai RY. 2013. Nucleostemin deletion reveals an essential mechanism that maintains the genomic stability of stem and progenitor cells. Proc Natl Acad Sci U S A 110(28):11415-20. [PubMed: 23798389]  [MGI Ref ID J:198698]

Ming M; Feng L; Shea CR; Soltani K; Zhao B; Han W; Smart RC; Trempus CS; He YY. 2011. PTEN Positively Regulates UVB-Induced DNA Damage Repair. Cancer Res 71(15):5287-95. [PubMed: 21771908]  [MGI Ref ID J:174190]

Ming M; Shea CR; Feng L; Soltani K; He YY. 2011. UVA induces lesions resembling seborrheic keratoses in mice with keratinocyte-specific PTEN downregulation. J Invest Dermatol 131(7):1583-6. [PubMed: 21390050]  [MGI Ref ID J:182077]

Missan DS; Chittur SV; DiPersio CM. 2014. Regulation of Fibulin-2 Gene Expression by Integrin alpha3beta1 Contributes to the Invasive Phenotype of Transformed Keratinocytes. J Invest Dermatol 134(9):2418-27. [PubMed: 24694902]  [MGI Ref ID J:212837]

Mitchell EH; Serra R. 2014. Normal mammary development and function in mice with Ift88 deleted in MMTV- and K14-Cre expressing cells. Cilia 3(1):4. [PubMed: 24594320]  [MGI Ref ID J:210639]

Mitchell K; Szekeres C; Milano V; Svenson KB; Nilsen-Hamilton M; Kreidberg JA; DiPersio CM. 2009. Alpha3beta1 integrin in epidermis promotes wound angiogenesis and keratinocyte-to-endothelial-cell crosstalk through the induction of MRP3. J Cell Sci 122(Pt 11):1778-87. [PubMed: 19435806]  [MGI Ref ID J:150583]

Molyneux G; Geyer FC; Magnay FA; McCarthy A; Kendrick H; Natrajan R; Mackay A; Grigoriadis A; Tutt A; Ashworth A; Reis-Filho JS; Smalley MJ. 2010. BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells. Cell Stem Cell 7(3):403-17. [PubMed: 20804975]  [MGI Ref ID J:164435]

Morrison KM; Miesegaes GR; Lumpkin EA; Maricich SM. 2009. Mammalian Merkel cells are descended from the epidermal lineage. Dev Biol 336(1):76-83. [PubMed: 19782676]  [MGI Ref ID J:154915]

Murphy MJ; Polok BK; Schorderet DF; Cleary ML. 2010. Essential role for Pbx1 in corneal morphogenesis. Invest Ophthalmol Vis Sci 51(2):795-803. [PubMed: 19797217]  [MGI Ref ID J:160421]

Murthy A; Shao YW; Narala SR; Molyneux SD; Zuniga-Pflucker JC; Khokha R. 2012. Notch activation by the metalloproteinase ADAM17 regulates myeloproliferation and atopic barrier immunity by suppressing epithelial cytokine synthesis. Immunity 36(1):105-19. [PubMed: 22284418]  [MGI Ref ID J:181258]

Nakrieko KA; Welch I; Dupuis H; Bryce D; Pajak A; St Arnaud R; Dedhar S; D'Souza SJ; Dagnino L. 2008. Impaired hair follicle morphogenesis and polarized keratinocyte movement upon conditional inactivation of integrin-linked kinase in the epidermis. Mol Biol Cell 19(4):1462-73. [PubMed: 18234842]  [MGI Ref ID J:172934]

Ni TK; Landrette SF; Bjornson RD; Bosenberg MW; Xu T. 2013. Low-copy piggyBac transposon mutagenesis in mice identifies genes driving melanoma. Proc Natl Acad Sci U S A 110(38):E3640-9. [PubMed: 24003131]  [MGI Ref ID J:201160]

Oda Y; Hu L; Bul V; Elalieh H; Reddy JK; Bikle DD. 2012. Coactivator MED1 ablation in keratinocytes results in hair-cycling defects and epidermal alterations. J Invest Dermatol 132(4):1075-83. [PubMed: 22189783]  [MGI Ref ID J:185244]

Ohazama A; Johnson EB; Ota MS; Choi HJ; Porntaveetus T; Oommen S; Itoh N; Eto K; Gritli-Linde A; Herz J; Sharpe PT. 2008. Lrp4 modulates extracellular integration of cell signaling pathways in development. PLoS ONE 3(12):e4092. [PubMed: 19116665]  [MGI Ref ID J:144348]

Ponugoti B; Xu F; Zhang C; Tian C; Pacios S; Graves DT. 2013. FOXO1 promotes wound healing through the up-regulation of TGF-beta1 and prevention of oxidative stress. J Cell Biol 203(2):327-43. [PubMed: 24145170]  [MGI Ref ID J:208099]

Rashel M; Alston N; Ghazizadeh S. 2014. Protein kinase d1 has a key role in wound healing and skin carcinogenesis. J Invest Dermatol 134(4):902-9. [PubMed: 24213370]  [MGI Ref ID J:207335]

Rice R; Spencer-Dene B; Connor EC; Gritli-Linde A; McMahon AP; Dickson C; Thesleff I; Rice DP. 2004. Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate. J Clin Invest 113(12):1692-700. [PubMed: 15199404]  [MGI Ref ID J:90909]

Sahu RP; Dasilva SC; Rashid B; Martel KC; Jernigan D; Mehta SR; Mohamed DR; Rezania S; Bradish JR; Armstrong AB; Warren S; Konger RL. 2012. Mice lacking epidermal PPARgamma exhibit a marked augmentation in photocarcinogenesis associated with increased UVB-induced apoptosis, inflammation and barrier dysfunction. Int J Cancer 131(7):E1055-66. [PubMed: 22467332]  [MGI Ref ID J:186081]

Sampath H; Flowers MT; Liu X; Paton CM; Sullivan R; Chu K; Zhao M; Ntambi JM. 2009. Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity. J Biol Chem 284(30):19961-73. [PubMed: 19429677]  [MGI Ref ID J:152631]

Schlegelmilch K; Mohseni M; Kirak O; Pruszak J; Rodriguez JR; Zhou D; Kreger BT; Vasioukhin V; Avruch J; Brummelkamp TR; Camargo FD. 2011. Yap1 acts downstream of alpha-catenin to control epidermal proliferation. Cell 144(5):782-95. [PubMed: 21376238]  [MGI Ref ID J:171057]

Shih MY; Kane MA; Zhou P; Yen CL; Streeper RS; Napoli JL; Farese RV Jr. 2009. Retinol Esterification by DGAT1 Is Essential for Retinoid Homeostasis in Murine Skin. J Biol Chem 284(7):4292-9. [PubMed: 19028692]  [MGI Ref ID J:147611]

Singh P; Chen C; Pal-Ghosh S; Stepp MA; Sheppard D; Van De Water L. 2009. Loss of integrin alpha9beta1 results in defects in proliferation, causing poor re-epithelialization during cutaneous wound healing. J Invest Dermatol 129(1):217-28. [PubMed: 18633440]  [MGI Ref ID J:144854]

Solovei I; Wang AS; Thanisch K; Schmidt CS; Krebs S; Zwerger M; Cohen TV; Devys D; Foisner R; Peichl L; Herrmann H; Blum H; Engelkamp D; Stewart CL; Leonhardt H; Joffe B. 2013. LBR and Lamin A/C Sequentially Tether Peripheral Heterochromatin and Inversely Regulate Differentiation. Cell 152(3):584-98. [PubMed: 23374351]  [MGI Ref ID J:193454]

Takekoshi T; Wu X; Mitsui H; Tada Y; Kao MC; Sato S; Dwinell MB; Hwang ST. 2013. CXCR4 Negatively Regulates Keratinocyte Proliferation in IL-23-Mediated Psoriasiform Dermatitis. J Invest Dermatol 133(11):2530-7. [PubMed: 23528817]  [MGI Ref ID J:202414]

Torchia EC; Zhang L; Huebner AJ; Sen S; Roop DR. 2013. Aurora kinase-A deficiency during skin development impairs cell division and stratification. J Invest Dermatol 133(1):78-86. [PubMed: 22832491]  [MGI Ref ID J:196491]

Verdoni AM; Ikeda S; Ikeda A. 2010. Serum response factor is essential for the proper development of skin epithelium. Mamm Genome 21(1-2):64-76. [PubMed: 20047077]  [MGI Ref ID J:156871]

Wang XP; O'Connell DJ; Lund JJ; Saadi I; Kuraguchi M; Turbe-Doan A; Cavallesco R; Kim H; Park PJ; Harada H; Kucherlapati R; Maas RL. 2009. Apc inhibition of Wnt signaling regulates supernumerary tooth formation during embryogenesis and throughout adulthood. Development 136(11):1939-49. [PubMed: 19429790]  [MGI Ref ID J:149542]

Wang Z; Zhang LJ; Guha G; Li S; Kyrylkova K; Kioussi C; Leid M; Ganguli-Indra G; Indra AK. 2012. Selective ablation of Ctip2/Bcl11b in epidermal keratinocytes triggers atopic dermatitis-like skin inflammatory responses in adult mice. PLoS One 7(12):e51262. [PubMed: 23284675]  [MGI Ref ID J:195636]

Weber S; Niessen MT; Prox J; Lullmann-Rauch R; Schmitz A; Schwanbeck R; Blobel CP; Jorissen E; de Strooper B; Niessen CM; Saftig P. 2011. The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling. Development 138(3):495-505. [PubMed: 21205794]  [MGI Ref ID J:170542]

Woo SH; Baba Y; Franco AM; Lumpkin EA; Owens DM. 2012. Excitatory glutamate is essential for development and maintenance of the piloneural mechanoreceptor. Development 139(4):740-8. [PubMed: 22241839]  [MGI Ref ID J:181187]

Woo SH; Ranade S; Weyer AD; Dubin AE; Baba Y; Qiu Z; Petrus M; Miyamoto T; Reddy K; Lumpkin EA; Stucky CL; Patapoutian A. 2014. Piezo2 is required for Merkel-cell mechanotransduction. Nature 509(7502):622-6. [PubMed: 24717433]  [MGI Ref ID J:211312]

Woo SH; Stumpfova M; Jensen UB; Lumpkin EA; Owens DM. 2010. Identification of epidermal progenitors for the Merkel cell lineage. Development 137(23):3965-71. [PubMed: 21041368]  [MGI Ref ID J:166901]

Yanagida J; Hammiller B; Al-Matouq J; Behrens M; Trempus CS; Repertinger SK; Hansen LA. 2012. Accelerated elimination of ultraviolet-induced DNA damage through apoptosis in CDC25A-deficient skin. Carcinogenesis 33(9):1754-61. [PubMed: 22764135]  [MGI Ref ID J:191020]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX11

Colony Maintenance

Breeding & HusbandryWhen maintaining the live colony, homozygous mice may be bred together.
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $239.00Female or MaleHomozygous for Tg(KRT14-cre)1Amc  
Price per Pair (US dollars $)Pair Genotype
$478.00Homozygous for Tg(KRT14-cre)1Amc x Homozygous for Tg(KRT14-cre)1Amc  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Cryopreserved

Frozen Products

Price (US dollars $)
Frozen Embryo $1650.00

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $310.70Female or MaleHomozygous for Tg(KRT14-cre)1Amc  
Price per Pair (US dollars $)Pair Genotype
$621.40Homozygous for Tg(KRT14-cre)1Amc x Homozygous for Tg(KRT14-cre)1Amc  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Cryopreserved

Frozen Products

Price (US dollars $)
Frozen Embryo $2145.00

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
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Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

  Control
   None Available
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
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Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
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Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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