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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Type Congenic; Major Histocompatibility Congenic; Mutant Strain; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Sibling x Sibling (Female x Male) 01-MAR-06 Species laboratory mouse Background Strain C57BL/10SnSg Donor Strain C57BR/cdJ Generation N9[F52p]+F10 (14-DEC-06) Appearance
black, may exhibit white belly spots
Related Genotype: a/aDescription
Some phenotypic parameters of the B10.BR-H2k H2-T18a/SgSnJ (Stock No. 000465) mice may have changed recently relative to the strain's previous performance. In order to confirm that a change has occurred and in order to better characterize any differences that may have arisen, animals were recovered from cryopreserved embryos of the strain (B10.BR-H2k H2-T18a/SgSnJJrep Stock No. 004804) that had been frozen in 1991, and the two lines of B10.BR-H2k H2-T18a/SgSnJ were compared. Differences between the two strains have been identified in the CD4/CD8 ratios among several cell populations, and in some dendritic cell populations. As more information is gathered, this website will be updated. Both colonies of B10.BR-H2k H2-T18a/SgSnJ (000465 and 004804) may exhibit white belly spots; these spots are considered a strain characteristic.
Control Information
| Control | ||
|---|---|---|
| 000666 C57BL/10SnJ | (approximate) | |
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying H2k allele
000465 B10.BR-H2k H2-T18a/SgSnJ 006100 B10.Cg-H2k Tg(NFkB/Fos-luc)26Rinc/J 006102 B10.Cg-H2k Tg(Il2/NFAT-luc)83Rinc/J 001148 B6.AK-H2k/FlaEgJ 001895 B6.AK-H2k/J 001951 C.C3-H2k/LilMcdJ 001383 LT.MA-Glo1b H2k/J View Strains carrying H2k (7 strains)
Additional Web Information
Genetic Quality Control Annual Report
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
H2k relatedImmunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Genes & Alleles
Gene & Allele Information
| Allele Symbol | H2k | ||
|---|---|---|---|
| Allele Name | k variant | ||
| Allele Type | Not Applicable | ||
| Common Name(s) | H-2k; | ||
| Gene Symbol and Name | H2, histocompatibility-2, MHC | ||
| Chromosome | 17 | ||
| Gene Common Name(s) | H-2; MHC-II; | ||
| General Note | The k variant has been observed in the following strains: C3H, C3H/HeJ, C3H/An, C3H/Bi, C3H/DiSn, C3H/St, CBA, CBA/CaJ, CBA/N, AKR/J, CE/J, C57BR/cdJ, C58/J, MA/J, RF/J, ST/bJ, MRL/MpJ-Faslpr/J | ||
| Gene Symbol and Name | H2-T18, histocompatibility 2, T region locus 18 | ||
| Chromosome | 17 | ||
| Gene Common Name(s) | H-2T18; TL Ag; Tla; thymus leukemia antigen; | ||
Genotyping
Genotyping Information
The Jackson Laboratory has not developed a genotyping protocol for H2 haplotypes. The following reference may helpful: Saha BK. J Immunol Meth 1996 Jul 17;194(1):77-83. (PMID: 8690943). Alternatively, haplotype-specific antibodies can be used with FACS.
Helpful Links
Genotyping resources and troubleshooting
References
References
Additional References
H2k relatedBlazar BR; Carreno BM; Panoskaltsis-Mortari A; Carter L; Iwai Y; Yagita H; Nishimura H; Taylor PA. 2003. Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-gamma-dependent mechanism. J Immunol 171(3):1272-7. [PubMed: 12874215] [MGI Ref ID J:120213]
Cemerski S; Das J; Locasale J; Arnold P; Giurisato E; Markiewicz MA; Fremont D; Allen PM; Chakraborty AK; Shaw AS. 2007. The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse. Immunity 26(3):345-55. [PubMed: 17346997] [MGI Ref ID J:120073]
Chiorazzi N; Fox DA; Katz DH. 1977. Hapten-specific IgE antibody responses in mice. VII. Conversion of IgE non-responder strains to IgE responders by elimination of suppressor T cell activity. J Immunol 118(1):48-54. [PubMed: 299762] [MGI Ref ID J:5739]
Clarke SR; Barnden M; Kurts C; Carbone FR; Miller JF; Heath WR. 2000. Characterization of the ovalbumin-specific TCR transgenic line OT-I: MHC elements for positive and negative selection. Immunol Cell Biol 78(2):110-7. [PubMed: 10762410] [MGI Ref ID J:133645]
Fischer Lindahl K. 1997. On naming H2 haplotypes: functional significance of MHC class Ib alleles. Immunogenetics 46(1):53-62. [PubMed: 9148789] [MGI Ref ID J:41130]
Gustavsson S; Wernersson S; Heyman B. 2000. Restoration of the antibody response to IgE/antigen complexes in CD23-deficient mice by CD23+ spleen or bone marrow cells. J Immunol 164(8):3990-5. [PubMed: 10754289] [MGI Ref ID J:112143]
Hegde S; Niederkorn JY. 2000. The role of cytotoxic T lymphocytes in corneal allograft rejection. Invest Ophthalmol Vis Sci 41(11):3341-7. [PubMed: 11006223] [MGI Ref ID J:115389]
Jenkinson EJ; Van Ewijk W; Owen JJ. 1981. Major histocompatibility complex antigen expression on the epithelium of the developing thymus in normal and nude mice. J Exp Med 153(2):280-92. [PubMed: 6940949] [MGI Ref ID J:109960]
Kaye J; Vasquez NJ; Hedrick SM. 1992. Involvement of the same region of the T cell antigen receptor in thymic selection and foreign peptide recognition. J Immunol 148(11):3342-53. [PubMed: 1316916] [MGI Ref ID J:124701]
Klein J; Figueroa F; David CS. 1983. H-2 haplotypes, genes and antigens: second listing. II. The H-2 complex. Immunogenetics 17(6):553-96. [PubMed: 6407984] [MGI Ref ID J:7097]
Lakkis FG; Arakelov A; Konieczny BT; Inoue Y. 2000. Immunologic 'ignorance' of vascularized organ transplants in the absence of secondary lymphoid tissue. Nat Med 6(6):686-8. [PubMed: 10835686] [MGI Ref ID J:118716]
Le PH; Leiter EH; Leyendecker JR. 1985. Genetic control of susceptibility to streptozotocin diabetes in inbred mice: effect of testosterone and H-2 haplotype. Endocrinology 116(6):2450-5. [PubMed: 3888611] [MGI Ref ID J:109951]
Liu P; Aitken K; Kong YY; Opavsky MA; Martino T; Dawood F; Wen WH; Kozieradzki I; Bachmaier K; Straus D; Mak TW; Penninger JM. 2000. The tyrosine kinase p56lck is essential in coxsackievirus B3-mediated heart disease. Nat Med 6(4):429-34. [PubMed: 10742150] [MGI Ref ID J:119597]
Lucas JA; Atherly LO; Berg LJ. 2002. The absence of Itk inhibits positive selection without changing lineage commitment. J Immunol 168(12):6142-51. [PubMed: 12055226] [MGI Ref ID J:123795]
Mendiratta SK; Kovalik JP; Hong S; Singh N; Martin WD; Van Kaer L. 1999. Peptide dependency of alloreactive CD4+ T cell responses. Int Immunol 11(3):351-60. [PubMed: 10221647] [MGI Ref ID J:110542]
Merino R; Shibata T; De Kossodo S; Izui S. 1989. Differential effect of the autoimmune Yaa and lpr genes on the acceleration of lupus-like syndrome in MRL/MpJ mice. Eur J Immunol 19(11):2131-7. [PubMed: 2599002] [MGI Ref ID J:108759]
Miyashita N; Migita S; Moriwaki K. 1987. Effects of H-2 complex and non-H-2 background on urethane-induced chromosomal aberrations in mice. Mutat Res 176(1):59-67. [PubMed: 3099189] [MGI Ref ID J:109945]
Murphy DB. 1986. Overview: the murine MHC. In: Handbook of Experimental Immunology. Vol. 3, Genetic and Molecular Immunology. Blackwell Scientific Publ., Oxford. [MGI Ref ID J:30731]
Panoskaltsis-Mortari A; Hermanson JR; Taras E; Wangensteen OD; Charo IF; Rollins BJ; Blazar BR. 2004. Post-BMT lung injury occurs independently of the expression of CCL2 or its receptor, CCR2, on host cells. Am J Physiol Lung Cell Mol Physiol 286(2):L284-92. [PubMed: 14527928] [MGI Ref ID J:101226]
Podolin PL; Pressey A; DeLarato NH; Fischer PA; Peterson LB; Wicker LS. 1993. I-E+ nonobese diabetic mice develop insulitis and diabetes. J Exp Med 178(3):793-803. [PubMed: 8350054] [MGI Ref ID J:14178]
Qiu H; Wang S; Yang J; Fan Y; Joyee AG; Han X; Jiao L; Yang X. 2005. Resistance to chlamydial lung infection is dependent on major histocompatibility complex as well as non-major histocompatibility complex determinants. Immunology 116(4):499-506. [PubMed: 16313363] [MGI Ref ID J:106140]
Sharma RB; Alegria JD; Talor MV; Rose NR; Caturegli P; Burek CL. 2005. Iodine and IFN-gamma synergistically enhance intercellular adhesion molecule 1 expression on NOD.H2h4 mouse thyrocytes. J Immunol 174(12):7740-5. [PubMed: 15944276] [MGI Ref ID J:100880]
Sutton VR; Waterhouse NJ; Browne KA; Sedelies K; Ciccone A; Anthony D; Koskinen A; Mullbacher A; Trapani JA. 2007. Residual active granzyme B in cathepsin C-null lymphocytes is sufficient for perforin-dependent target cell apoptosis. J Cell Biol 176(4):425-33. [PubMed: 17283185] [MGI Ref ID J:119725]
Venkatesan P; Finch RG; Wakelin D. 1993. MHC haplotype influences primary Giardia muris infections in H-2 congenic strains of mice. Int J Parasitol 23(5):661-4. [PubMed: 8225770] [MGI Ref ID J:21687]
Willse A; Kwak J; Yamazaki K; Preti G; Wahl JH; Beauchamp GK. 2006. Individual odortypes: interaction of MHC and background genes. Immunogenetics 58(12):967-82. [PubMed: 17089117] [MGI Ref ID J:116154]
Zhang ZX; Yang L; Young KJ; DuTemple B; Zhang L. 2000. Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression. Nat Med 6(7):782-9. [PubMed: 10888927] [MGI Ref ID J:118729]
Zhou P; Szot GL; Guo Z; Kim O; He G; Wang J; Grusby MJ; Newell KA; Thistlethwaite JR; Bluestone JA; Alegre ML. 2000. Role of STAT4 and STAT6 signaling in allograft rejection and CTLA4-Ig-mediated tolerance. J Immunol 165(10):5580-7. [PubMed: 11067913] [MGI Ref ID J:119580]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number MP21
Colony Maintenance
Mating System Sibling x Sibling (Female x Male) 01-MAR-06 Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
|
Weeks of Age Price (US dollars $) Gender Genotypes Provided 3-5 weeks $30.70 Female or Male Homozygous for H2k, Homozygous for H2-T18a 6 weeks $32.75 Female or Male Homozygous for H2k, Homozygous for H2-T18a 7 weeks $34.80 Female or Male Homozygous for H2k, Homozygous for H2-T18a 8 weeks $36.85 Female or Male Homozygous for H2k, Homozygous for H2-T18a
Additional Supply Details
| Pricing for International shipping destinations |
|
Weeks of Age Price (US dollars $) Gender Genotypes Provided 3-5 weeks $40.00 Female or Male Homozygous for H2k, Homozygous for H2-T18a 6 weeks $42.70 Female or Male Homozygous for H2k, Homozygous for H2-T18a 7 weeks $45.40 Female or Male Homozygous for H2k, Homozygous for H2-T18a 8 weeks $48.10 Female or Male Homozygous for H2k, Homozygous for H2-T18a
Additional Supply Details
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Supply Details
| Standard Supply | Level 3. Up to 50 mice. Larger quantities or custom orders arranged upon request. |
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| Supply Notes |
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Control Information
| Control | ||
|---|---|---|
| 000666 C57BL/10SnJ | (approximate) | |
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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