Strain Name:

B6;129-Psen1tm1Mpm Tg(APPSwe,tauP301L)1Lfa/Mmjax

Availability:

Repository- Live     Available at the JAX MMRRC

Use Restrictions Apply, see Terms of Use
Common Names: 3xTg-AD;    
This strain is now distributed by the Mutant Mouse Regional Resource Center. Please refer to the Mutant Mouse Regional Resource Center (MMRRC) for ordering information and strain details on B6;129-Psen1 Tg(APPSwe,tauP301L)1Lfa/Mmjax MMRRC Stock Number 034830.
As a designated MMRRC center, The Jackson Laboratory will continue to distribute these mice at the same high health and
quality standards but ordering is exclusively provided through the MMRRC.
These 3xTg-AD mice (formerly JAX Stock No. 004807) are useful when studying plaque and tangle pathology associated with synaptic dysfunction and Alzheimer's disease.

Description

Strain Information

Former Names B6;129-Psen1tm1Mpm Tg(APPSwe,tauP301L)1Lfa/J    (Changed: 10-AUG-11 )
B6.Cg-Psen1tm1Mpm Tg(APPSwe,tauP301L)1Lfa/J    (Changed: 07-AUG-09 )
C57BL/6-Psen1tm1Mpm Tg(APPSwe,tauP301L)1Lfa/J    (Changed: 13-MAR-08 )
C57BL/6-Psen1tm1Mpm Tg(APPSwe, tauP301L)1Lfa/J    (Changed: 30-MAR-06 )
Type Mutant Stock; Targeted Mutation; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Mating SystemSee Colony Maintenance under the Health & Care tab         (Female x Male)   28-OCT-13
Specieslaboratory mouse
GenerationF?+F13 (26-SEP-14)
Generation Definitions
 
Donating Investigator Frank LaFerla,   University of California, Irvine

Description
Mice homozygous for all three mutant alleles (3xTg-AD; homozygous for the Psen1 mutation and homozygous for the co-injected APPSwe and tauP301L transgenes (Tg(APPSwe,tauP301L)1Lfa)) are viable, fertile and display no initial gross physical or behavioral abnormalities. Translation of the overexpressed transgenes appears to be restricted to the central nervous system, notably in Alzheimer's disease-relevant areas including the hippocampus and cerebral cortex. The initial characterization of this mouse line indicated a progressive increase in amyloid beta peptide deposition, with intracellular immunoreactivity being detected in some brain regions as early as 3-4 months. Synaptic transmission and long-term potentiation are demonstrably impaired in mice 6 months of age. Between 12-15 months aggregates of conformationally altered and hyperphosphorylated tau are detected in the hippocampus. This mutant mouse exhibits plaque and tangle pathology associated with synaptic dysfunction, traits similar to those observed in Alzheimer's disease patients. The donating investigator recently communicated (February 2014) that, in contrast to the initial observations, male transgenic mice may not exhibit the phenotypic traits originally described. No reports of diminished traits in female carriers have been reported.

Development
Single-cell embryos from mice bearing the presenilin PS1M146V knockin mutation on a mixed C7BL/6;129X1/SvJ;129S1/Sv genetic background (B6;129-Psen1tm1Mpm) were co-injected with two independent mutant human transgenes; amyloid beta precursor protein (APPSwe) and microtubule-associated protein tau (tauP30IL). Both transgenes integrated at the same locus and are under the control of the mouse Thy1.2 regulatory element. Founder mice (line B1) were mated to B6;129-Psen1tm1Mpm mice. Offspring from this cross were bred together, resulting in mice homozygous for all three alleles (3xTg-AD; homozygous for the Psen1 mutation and homozygous for the co-injected APPSwe and tauP301L transgenes (Tg(APPSwe,tauP301L)1Lfa)). Both male and female 3xTg-AD mice on the mixed C7BL/6;129X1/SvJ;129S1/Sv genetic background were sent to The Jackson Laboratory and bred together to establish this colony for the MMRRC.

Control Information

  Control
   101045 B6129SF2/J (approximate)
 
  Considerations for Choosing Controls

Related Strains

Alzheimer's Disease Models
005987   129-Achetm1Loc/J
006409   129S1.129(Cg)-Tg(APPSw)40Btla/Mmjax
008077   129S1/Sv-Bchetm1Loc/J
016198   129S6.Cg-Tg(Camk2a-tTA)1Mmay/JlwsJ
014556   129S6/SvEv-Apoetm4Mae/J
006555   A.129(B6)-Tg(APPSw)40Btla/Mmjax
005708   B6.129-Apbb1tm1Quhu/J
004714   B6.129-Bace1tm1Pcw/J
004098   B6.129-Klc1tm1Gsn/J
004193   B6.129-Psen1tm1Mpm/J
003615   B6.129-Psen1tm1Shn/J
005300   B6.129-Tg(APPSw)40Btla/Mmjax
005617   B6.129P-Psen2tm1Bdes/J
002609   B6.129P2-Nos2tm1Lau/J
007685   B6.129P2-Psen1tm1Vln/J
007999   B6.129P2-Sorl1Gt(Ex255)Byg/J
008087   B6.129S1-Bchetm1Loc/J
002509   B6.129S2-Plautm1Mlg/J
005301   B6.129S2-Tg(APP)8.9Btla/J
004163   B6.129S4-Cdk5r1tm1Lht/J
010959   B6.129S4-Grk5tm1Rjl/J
010960   B6.129S4-Grk5tm2Rjl/J
002213   B6.129S4-Ngfrtm1Jae/J
006406   B6.129S4-Tg(APPSwLon)96Btla/Mmjax
006469   B6.129S4-Tg(PSEN1H163R)G9Btla/J
012564   B6.129S5-Dhcr24tm1Lex/SbpaJ
004142   B6.129S7-Aplp2tm1Dbo/J
004133   B6.129S7-Apptm1Dbo/J
007251   B6.129X1-Mapttm1Hnd/J
013040   B6.Cg-Apoetm1Unc Ins2Akita/J
005642   B6.Cg-Clutm1Jakh/J
005491   B6.Cg-Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
009126   B6.Cg-Nos2tm1Lau Tg(Thy1-APPSwDutIowa)BWevn/Mmjax
005866   B6.Cg-Tg(APP695)3Dbo Tg(PSEN1dE9)S9Dbo/Mmjax
008730   B6.Cg-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax
005864   B6.Cg-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax
007575   B6.Cg-Tg(CAG-Ngb,-EGFP)1Dgrn/J
016197   B6.Cg-Tg(CAG-OTC/CAT)4033Prab/J
005855   B6.Cg-Tg(Camk2a-Prkaca)426Tabe/J
007004   B6.Cg-Tg(Camk2a-tTA)1Mmay/DboJ
004996   B6.Cg-Tg(DBH-Gal)1923Stei/J
007673   B6.Cg-Tg(Gad1-EGFP)3Gfng/J
004662   B6.Cg-Tg(PDGFB-APP)5Lms/J
006293   B6.Cg-Tg(PDGFB-APPSwInd)20Lms/2Mmjax
006006   B6.Cg-Tg(Prnp-APP)A-2Dbo/J
008596   B6.Cg-Tg(Prnp-Abca1)EHol/J
006005   B6.Cg-Tg(Prnp-App/APPswe)E1-2Dbo/Mmjax
007180   B6.Cg-Tg(Prnp-ITM2B/APP695*40)1Emcg/J
007182   B6.Cg-Tg(Prnp-ITM2B/APP695*42)A12Emcg/J
005999   B6.Cg-Tg(SBE/TK-luc)7Twc/J
012597   B6.Cg-Tg(Thy1-COL25A1)861Yfu/J
007051   B6.Cg-Tg(tetO-APPSwInd)102Dbo/Mmjax
007052   B6.Cg-Tg(tetO-APPSwInd)107Dbo/Mmjax
007049   B6.Cg-Tg(tetO-APPSwInd)885Dbo/Mmjax
009337   B6.FVB-Tg(Prnp-RTN3)2Yanr/J
006394   B6;129-Apba2tm1Sud Apba3tm1Sud Apba1tm1Sud/J
008364   B6;129-Chattm1(cre/ERT)Nat/J
008476   B6;129-Ncstntm1Sud/J
007605   B6;129P-Psen1tm1Vln/J
005618   B6;129P2-Bace2tm1Bdes/J
008333   B6;129P2-Dldtm1Ptl/J
002596   B6;129P2-Nos2tm1Lau/J
003822   B6;129S-Psen1tm1Shn/J
012639   B6;129S4-Mapttm3(HDAC2)Jae/J
012869   B6;129S6-Apbb2tm1Her/J
006410   B6;129S6-Chattm2(cre)Lowl/J
005993   B6;129S6-Pcsk9tm1Jdh/J
008636   B6;C-Tg(Prnp-APP695*/EYFP)49Gsn/J
007002   B6;C3-Tg(Prnp-ITM2B/APP695*42)A12Emcg/Mmjax
008169   B6;C3-Tg(Prnp-MAPT*P301S)PS19Vle/J
000231   B6;C3Fe a/a-Csf1op/J
008850   B6;SJL-Tg(Mt1-LDLR)93-4Reh/AgnJ
003378   B6C3-Tg(APP695)3Dbo Tg(PSEN1)5Dbo/J
004462   B6C3-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax
003741   B6D2-Tg(Prnp-MAPT)43Vle/J
016556   B6N.129-Ptpn5tm1Pjlo/J
018957   B6N.129S6(B6)-Chattm2(cre)Lowl/J
024841   B6N.Cg-Tg(Prnp-MAPT*P301S)PS19Vle/J
006554   B6SJL-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax
012621   C.129S(B6)-Chrna3tm1.1Hwrt/J
002328   C.129S2-Plautm1Mlg/J
003375   C3B6-Tg(APP695)3Dbo/Mmjax
005087   C57BL/6-Tg(Camk2a-IDE)1Selk/J
005086   C57BL/6-Tg(Camk2a-MME)3Selk/J
008833   C57BL/6-Tg(Camk2a-UBB)3413-1Fwvl/J
007027   C57BL/6-Tg(Thy1-APPSwDutIowa)BWevn/Mmjax
010800   C57BL/6-Tg(Thy1-PTGS2)300Kand/J
010703   C57BL/6-Tg(Thy1-PTGS2)303Kand/J
005706   C57BL/6-Tg(tetO-CDK5R1/GFP)337Lht/J
006618   C57BL/6-Tg(tetO-COX8A/EYFP)1Ksn/J
007677   CB6-Tg(Gad1-EGFP)G42Zjh/J
007072   CByJ.129P2(B6)-Nos2tm1Lau/J
006472   D2.129(B6)-Tg(APPSw)40Btla/Mmjax
007067   D2.129P2(B6)-Apoetm1Unc/J
013719   D2.Cg-Apoetm1Unc Ins2Akita/J
003718   FVB-Tg(GadGFP)45704Swn/J
013732   FVB-Tg(NPEPPS)1Skar/J
013156   FVB-Tg(tetO-CDK5R1*)1Vln/J
015815   FVB-Tg(tetO-MAPT*P301L)#Kha/JlwsJ
002329   FVB.129S2-Plautm1Mlg/J
003753   FVB/N-Tg(Eno2CDK5R1)1Jdm/J
006143   FVB/N-Tg(Thy1-cre)1Vln/J
008051   NOD.129P2(B6)-Ctsbtm1Jde/RclJ
008390   STOCK Apptm1Sud/J
012640   STOCK Hdac2tm1.2Rdp/J
004808   STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
004779   STOCK Mapttm1(EGFP)Klt/J
014092   STOCK Tg(ACTB-tTA2,-MAPT/lacZ)1Luo/J
014544   STOCK Tg(tetO-ABL1*P242E*P249E)CPdav/J
View Alzheimer's Disease Models     (109 strains)

Parkinson's Disease Models
005987   129-Achetm1Loc/J
007587   129S-Park2tm1Rpa/J
002779   129S-Parp1tm1Zqw/J
017001   129S.B6N-Plk2tm1Elan/J
016198   129S6.Cg-Tg(Camk2a-tTA)1Mmay/JlwsJ
004608   B6(Cg)-Htra2mnd2/J
021828   B6(SJL)-Lrrk2tm3.1Mjff/J
008133   B6.129-Sncbtm1Sud/J
008084   B6.129P2-Drd4tm1Dkg/J
004744   B6.129P2-Esr1tm1Ksk/J
013586   B6.129P2-Gt(ROSA)26Sortm1Nik/J
002609   B6.129P2-Nos2tm1Lau/J
008843   B6.129P2-Sncgtm1Vlb/J
016566   B6.129S-Hcn1tm2Kndl/J
004322   B6.129S1-Mapk10tm1Flv/J
003190   B6.129S2-Drd2tm1Low/J
006582   B6.129S4-Park2tm1Shn/J
017946   B6.129S4-Pink1tm1Shn/J
005934   B6.129S4-Ucp2tm1Lowl/J
004936   B6.129S6(Cg)-Spp1tm1Blh/J
012453   B6.129X1(FVB)-Lrrk2tm1.1Cai/J
017009   B6.129X1-Nfe2l2tm1Ywk/J
009346   B6.Cg-Lrrk2tm1.1Shn/J
005491   B6.Cg-Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
006577   B6.Cg-Park7tm1Shn/J
000567   B6.Cg-T2J +/+ Qkqk-v/J
007004   B6.Cg-Tg(Camk2a-tTA)1Mmay/DboJ
003139   B6.Cg-Tg(DBHn-lacZ)8Rpk/J
007673   B6.Cg-Tg(Gad1-EGFP)3Gfng/J
012466   B6.Cg-Tg(Lrrk2)6Yue/J
012467   B6.Cg-Tg(Lrrk2*G2019S)2Yue/J
008323   B6.Cg-Tg(Mc4r-MAPT/Sapphire)21Rck/J
008321   B6.Cg-Tg(Npy-MAPT/Sapphire)1Rck/J
008324   B6.Cg-Tg(Pmch-MAPT/CFP)1Rck/J
008322   B6.Cg-Tg(Pomc-MAPT/Topaz)1Rck/J
007894   B6.Cg-Tg(Rgs4-EGFP)4Lvt/J
012588   B6.Cg-Tg(TH-ALPP)1Erav/J
012265   B6.Cg-Tg(THY1-SNCA*A30P)TS2Sud/J
008859   B6.Cg-Tg(THY1-SNCA*A53T)F53Sud/J
008135   B6.Cg-Tg(THY1-SNCA*A53T)M53Sud/J
008601   B6.Cg-Tg(Th-cre)1Tmd/J
013583   B6.Cg-Tg(tetO-LRRK2)C7874Cai/J
000544   B6.D2-Cacna1atg/J
012445   B6.FVB-Tg(LRRK2)WT1Mjfa/J
012446   B6.FVB-Tg(LRRK2*G2019S)1Mjfa/J
006660   B6.SJL-Slc6a3tm1.1(cre)Bkmn/J
008364   B6;129-Chattm1(cre/ERT)Nat/J
009688   B6;129-Dbhtm2(Th)Rpa Thtm1Rpa/J
008883   B6;129-Gt(ROSA)26Sortm1(SNCA*A53T)Djmo/TmdJ
008889   B6;129-Gt(ROSA)26Sortm2(SNCA*119)Djmo/TmdJ
008886   B6;129-Gt(ROSA)26Sortm3(SNCA*E46K)Djmo/TmdJ
009347   B6;129-Lrrk2tm1.1Shn/J
016209   B6;129-Lrrk2tm2.1Shn/J
016210   B6;129-Lrrk2tm3.1Shn/J
013050   B6;129-Pink1tm1Aub/J
006390   B6;129-Sncatm1Sud Sncbtm1.1Sud/J
008532   B6;129-Thtm1(cre/Esr1)Nat/J
008333   B6;129P2-Dldtm1Ptl/J
008333   B6;129P2-Dldtm1Ptl/J
002596   B6;129P2-Nos2tm1Lau/J
003243   B6;129S-Tnfrsf1atm1Imx Tnfrsf1btm1Imx/J
003692   B6;129X1-Sncatm1Rosl/J
016575   B6;C3-Tg(PDGFB-LRRK2*G2019S)340Djmo/J
016576   B6;C3-Tg(PDGFB-LRRK2*R1441C)574Djmo/J
008169   B6;C3-Tg(Prnp-MAPT*P301S)PS19Vle/J
004479   B6;C3-Tg(Prnp-SNCA*A53T)83Vle/J
000231   B6;C3Fe a/a-Csf1op/J
012450   B6;D2-Tg(tetO-SNCA)1Cai/J
013725   B6;SJL-Tg(LRRK2)66Mjff/J
008473   B6;SJL-Tg(THY1-SNCA*A30P)M30Sud/J
008134   B6;SJL-Tg(THY1-SNCA*A30P)TS2Sud/J
016976   B6C3-Tg(tetO-SNCA*A53T)33Vle/J
000506   B6C3Fe a/a-Qkqk-v/J
003741   B6D2-Tg(Prnp-MAPT)43Vle/J
024841   B6N.Cg-Tg(Prnp-MAPT*P301S)PS19Vle/J
018768   B6N.Cg-Tg(SNCA*E46K)3Elan/J
012621   C.129S(B6)-Chrna3tm1.1Hwrt/J
016120   C57BL/6-Lrrk1tm1.1Mjff/J
012444   C57BL/6-Lrrk2tm1Mjfa/J
008389   C57BL/6-Tg(THY1-SNCA)1Sud/J
012769   C57BL/6-Tg(Thy1-Sncg)HvP36Putt/J
005706   C57BL/6-Tg(tetO-CDK5R1/GFP)337Lht/J
006618   C57BL/6-Tg(tetO-COX8A/EYFP)1Ksn/J
018785   C57BL/6J-Tg(LRRK2*G2019S)2AMjff/J
018786   C57BL/6J-Tg(LRRK2*R1441G)3IMjff/J
008245   C57BL/6J-Tg(Th-SNCA)5Eric/J
008239   C57BL/6J-Tg(Th-SNCA*A30P*A53T)39Eric/J
016122   C57BL/6N-Lrrk1tm1.1Mjff Lrrk2tm1.1Mjff/J
016121   C57BL/6N-Lrrk2tm1.1Mjff/J
016123   C57BL/6N-Sncatm1Mjff/J
016936   C57BL/6N-Tg(Thy1-SNCA)12Mjff/J
017682   C57BL/6N-Tg(Thy1-SNCA)15Mjff/J
007677   CB6-Tg(Gad1-EGFP)G42Zjh/J
009610   FVB/N-Tg(LRRK2)1Cjli/J
009609   FVB/N-Tg(LRRK2*G2019S)1Cjli/J
009604   FVB/N-Tg(LRRK2*R1441G)135Cjli/J
009090   FVB/NJ-Tg(Slc6a3-PARK2*Q311X)AXwy/J
017678   FVB;129-Pink1tm1Aub Tg(Prnp-SNCA*A53T)AAub/J
017744   FVB;129-Tg(Prnp-SNCA*A53T)AAub/J
010710   FVB;129S6-Sncatm1Nbm Tg(SNCA)1Nbm/J
010788   FVB;129S6-Sncatm1Nbm Tg(SNCA*A30P)1Nbm Tg(SNCA*A30P)2Nbm/J
010799   FVB;129S6-Sncatm1Nbm Tg(SNCA*A53T)1Nbm Tg(SNCA*A53T)2Nbm/J
004808   STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
000942   STOCK Pitx3ak/2J
014092   STOCK Tg(ACTB-tTA2,-MAPT/lacZ)1Luo/J
006340   STOCK Tg(Gad1-EGFP)98Agmo/J
017000   STOCK Tg(SNCA*E46K)3Elan/J
008474   STOCK Tg(THY1-SNCA*A53T)F53Sud/J
008132   STOCK Tg(THY1-Snca)M1mSud/J
012441   STOCK Tg(tetO-LRRK2*G2019S)E3Cai/J
012442   STOCK Tg(tetO-SNCA*A53T)E2Cai/J
012449   STOCK Tg(teto-LRRK2)C7874Cai/J
View Parkinson's Disease Models     (112 strains)

Strains carrying   Psen1tm1Mpm allele
004193   B6.129-Psen1tm1Mpm/J
View Strains carrying   Psen1tm1Mpm     (1 strain)

View Strains carrying other alleles of APP     (16 strains)

View Strains carrying other alleles of MAPT     (19 strains)

Strains carrying other alleles of Psen1
003615   B6.129-Psen1tm1Shn/J
007685   B6.129P2-Psen1tm1Vln/J
004825   B6.129S4-Psen1tm2Shn/J
007605   B6;129P-Psen1tm1Vln/J
003822   B6;129S-Psen1tm1Shn/J
024025   B6N(Cg)-Psen1tm1.1(KOMP)Vlcg/J
View Strains carrying other alleles of Psen1     (6 strains)

Strains carrying other alleles of Thy1
005895   B10.Cg-Thy1a H2d Tg(TcraCl1,TcrbCl1)1Shrm/J
001317   B6.Cg-Gpi1a Thy1a Igha/J
017798   B6.Cg-Mapttm1Hnd Tg(Thy1-MAPT*)3610Gds/Mmjax
009126   B6.Cg-Nos2tm1Lau Tg(Thy1-APPSwDutIowa)BWevn/Mmjax
025855   B6.Cg-Ptprca Lag3tm1Doi Tg(CAG-luc,-GFP)L2G85Chco Thy1a/J
022073   B6.Cg-Rag1tm1Mom Thy1a Tg(Tcra2C,Tcrb2C)1Dlo/J
014550   B6.Cg-Thy1a Tg(TcraCWM5,TcrbCWM5)1807Wuth/J
005023   B6.Cg-Thy1a/Cy Tg(TcraTcrb)8Rest/J
008730   B6.Cg-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax
007901   B6.Cg-Tg(Thy1-Brainbow1.0)HLich/J
007911   B6.Cg-Tg(Thy1-Brainbow1.1)MLich/J
007921   B6.Cg-Tg(Thy1-Brainbow2.1)RLich/J
003710   B6.Cg-Tg(Thy1-CFP)23Jrs/J
014131   B6.Cg-Tg(Thy1-CFP)IJrs/GfngJ
007940   B6.Cg-Tg(Thy1-CFP/COX8A)C1Lich/J
007967   B6.Cg-Tg(Thy1-CFP/COX8A)S2Lich/J
012597   B6.Cg-Tg(Thy1-COL25A1)861Yfu/J
007612   B6.Cg-Tg(Thy1-COP4/EYFP)18Gfng/J
007615   B6.Cg-Tg(Thy1-COP4/EYFP)9Gfng/J
013161   B6.Cg-Tg(Thy1-Clomeleon)1Gjau/J
007919   B6.Cg-Tg(Thy1-EGFP)OJrs/GfngJ
005630   B6.Cg-Tg(Thy1-EYFP)15Jrs/J
009611   B6.Cg-Tg(Thy1-Nlgn1)6Hnes/J
009612   B6.Cg-Tg(Thy1-Nlgn2)6Hnes/J
021069   B6.Cg-Tg(Thy1-PA-GFP)5Rmpl/J
021070   B6.Cg-Tg(Thy1-PA-GFP)6Rmpl/J
003709   B6.Cg-Tg(Thy1-YFP)16Jrs/J
003782   B6.Cg-Tg(Thy1-YFP)HJrs/J
005627   B6.Cg-Tg(Thy1-YFP/Syp)10Jrs/J
007606   B6.Cg-Tg(Thy1-cre/ERT2,-EYFP)AGfng/J
025854   B6.FVB-Ptprca Tg(CAG-luc,-GFP)L2G85Chco Thy1a/J
000406   B6.PL-Thy1a/CyJ
000983   B6.PL/(84NS)CyJ
007910   B6;CBA-Tg(Thy1-Brainbow1.0)LLich/J
011070   B6;CBA-Tg(Thy1-EGFP)SJrs/NdivJ
017892   B6;CBA-Tg(Thy1-GCaMP2.2c)8Gfng/J
017893   B6;CBA-Tg(Thy1-GCaMP3)6Gfng/J
014130   B6;CBA-Tg(Thy1-YFP)GJrs/GfngJ
014651   B6;CBA-Tg(Thy1-spH)21Vnmu/J
015814   B6;CBA-Tg(Thy1-spH)64Vnmu/FrkJ
012341   B6;SJL-Tg(Thy1-COP3/EYFP)1Gfng/J
012344   B6;SJL-Tg(Thy1-COP3/EYFP)4Gfng/J
012348   B6;SJL-Tg(Thy1-COP3/EYFP)8Gfng/J
012350   B6;SJL-Tg(Thy1-COP4*H134R/EYFP)20Gfng/J
008004   B6;SJL-Tg(Thy1-ECFP/VAMP2)1Sud/J
012836   B6;SJL-Tg(Thy1-TARDBP)4Singh/J
007610   B6;SJL-Tg(Thy1-cre/ERT2,-EYFP)VGfng/J
012332   B6;SJL-Tg(Thy1-hop/EYFP)2Gfng/J
012334   B6;SJL-Tg(Thy1-hop/EYFP)4Gfng/J
006554   B6SJL-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax
025401   B6SJL-Tg(Thy1-COX8A/Dendra)57Gmnf/J
017590   B6SJL-Tg(Thy1-DCTN1*G59S)M2Pcw/J
007880   B6SJL-Tg(Thy1-Stx1a/EYFP)1Sud/J
007856   B6SJL-Tg(Thy1-Syt1/ECFP)1Sud/J
017589   B6SJL-Tg(Thy1-TARDBP*G298S)S97Pcw/J
017351   BKa.Cg-Ptprcb Bmi1tm1Ilw Thy1a/J
007687   BKa.Cg-Sox17tm1Sjm Ptprcb Thy1a/J
007686   BKa.Cg-Sox17tm2Sjm Ptprcb Thy1a/J
024703   C3A.Cg-Pde6b+Tg(Thy1-CFP)23Jrs/SjJ
007027   C57BL/6-Tg(Thy1-APPSwDutIowa)BWevn/Mmjax
010800   C57BL/6-Tg(Thy1-PTGS2)300Kand/J
010703   C57BL/6-Tg(Thy1-PTGS2)303Kand/J
012769   C57BL/6-Tg(Thy1-Sncg)HvP36Putt/J
024339   C57BL/6J-Tg(Thy1-GCaMP6f)GP5.11Dkim/J
025393   C57BL/6J-Tg(Thy1-GCaMP6f)GP5.17Dkim/J
024276   C57BL/6J-Tg(Thy1-GCaMP6f)GP5.5Dkim/J
025776   C57BL/6J-Tg(Thy1-GCaMP6s)GP4.12Dkim/J
024275   C57BL/6J-Tg(Thy1-GCaMP6s)GP4.3Dkim/J
025533   C57BL/6N-Sncatm1Mjff Tg(Thy1-SNCA)15Mjff/J
016936   C57BL/6N-Tg(Thy1-SNCA)12Mjff/J
017682   C57BL/6N-Tg(Thy1-SNCA)15Mjff/J
005307   CBy.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
005922   CBy.Cg-Thy1a Tg(TcraCl1,TcrbCl1)1Shrm/J
005443   CBy.PL(B6)-Thy1a/ScrJ
024704   D2.Cg-Gpnmb+Tg(Thy1-CFP)23Jrs/SjJ
025018   D2.Cg-Gpnmb+Tg(Thy1-YFP)HJrs/SjJ
018671   D2.Cg-Tg(Thy1-CFP)23Jrs/SjJ
024705   D2.Cg-Tg(Thy1-YFP)HJrs/SjJ
025019   D2.Cg-Tg(Thy1-YFP/Syp)10Jrs/SjJ
008230   FVB(Cg)-Tg(Thy1-SOD1*G93A)T3Hgrd/J
006143   FVB/N-Tg(Thy1-cre)1Vln/J
024476   NOD.Cg-Stat4tm1Gru Thy1a Ifngr1tm1Agt Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/LmbrJ
005686   NOD.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
004483   NOD.NON-Thy1a/1LtJ
002721   NOD.NON-Thy1a/J
005651   SJL.AK-Thy1a/TseJ
003961   SJL.Cg Thy1a-Noxo1hslt/J
021226   STOCK Tg(Thy1-Brainbow3.1)18Jrs/J
021225   STOCK Tg(Thy1-Brainbow3.1)3Jrs/J
021227   STOCK Tg(Thy1-Brainbow3.2)7Jrs/J
013162   STOCK Tg(Thy1-Clomeleon)12Gjau/J
013163   STOCK Tg(Thy1-Clomeleon)13Gjau/J
007788   STOCK Tg(Thy1-EGFP)MJrs/J
012708   STOCK Tg(Thy1-cre/ERT2,-EYFP)HGfng/PyngJ
View Strains carrying other alleles of Thy1     (94 strains)

Additional Web Information

Visit the Alzheimer's Disease Mouse Model Resource site for helpful information on Alzheimer's Disease and research resources.

Visit the Parkinson's Disease Resource site for helpful information on Parkinson's and research resources.

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Characteristics of this human disease are associated with transgenes and other mutation types in the mouse.
Alzheimer Disease; AD
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Acne Inversa, Familial, 3; ACNINV3   (PSEN1)
Alzheimer Disease 3   (PSEN1)
Cardiomyopathy, Dilated, 1u; CMD1U   (PSEN1)
Frontotemporal Dementia; FTD   (PSEN1)
Pick Disease of Brain   (PSEN1)
- Potential model based on transgenic expression of an ortholog of a human gene that is associated with this disease. Phenotypic similarity to the human disease has not been tested.
Cerebral Amyloid Angiopathy, App-Related   (APP)
Parkinson Disease, Late-Onset; PD   (MAPT)
Parkinson-Dementia Syndrome   (MAPT)
Supranuclear Palsy, Progressive, 1; PSNP1   (MAPT)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Psen1tm1Mpm/Psen1tm1Mpm Tg(APPSwe,tauP301L)1Lfa/?

        involves: 129S1/Sv * 129X1/SvJ * C57BL/6
  • nervous system phenotype
  • amyloid beta deposits
    • Abeta oligomers begin to accumulate between 2 and 6 months of age, with continued age-dependent increase observed between 12 and 20 months   (MGI Ref ID J:107286)
    • intraneuronal oligomers are detected at 4-6 months of age   (MGI Ref ID J:107286)
  • neurofibrillary tangles
    • tau pathology is detected initially by 6 months of age, and tangle pathology is advanced by 20 months   (MGI Ref ID J:107286)
  • homeostasis/metabolism phenotype
  • amyloid beta deposits
    • Abeta oligomers begin to accumulate between 2 and 6 months of age, with continued age-dependent increase observed between 12 and 20 months   (MGI Ref ID J:107286)
    • intraneuronal oligomers are detected at 4-6 months of age   (MGI Ref ID J:107286)

Psen1tm1Mpm/Psen1tm1Mpm Tg(APPSwe,tauP301L)1Lfa/?

        B6.Cg-Psen1tm1Mpm Tg(APPSwe,tauP301L)1Lfa
  • behavior/neurological phenotype
  • abnormal behavior
    • mutants attend less accurately to short, spatially unpredictable stimuli when the attentional demand of the task is high and also show a general tendency to make more perseverative responses than wild-type mice   (MGI Ref ID J:170670)
    • mutants initially respond as accurately as wild-type mice, however subsequently they fail to sustain their attention over the duration of the task, indicating reduced vigilance, or ability to sustain attention over a long period of time   (MGI Ref ID J:170670)
    • treatment of mice with the cholinesterase inhibitor donepezil results in an enhanced ability to sustain attention   (MGI Ref ID J:170670)

Psen1tm1Mpm/Psen1tm1Mpm Tg(APPSwe,tauP301L)1Lfa/Tg(APPSwe,tauP301L)1Lfa

        involves: 129S1/Sv * 129X1/SvJ * C57BL/6
  • behavior/neurological phenotype
  • abnormal learning/memory/conditioning
    • in Morris water mazed, learning of task is normal but retention is impaired; 6-month old mice require 6 days of training to achieve escape latency of >20 seconds, compared to 3 days in 2 month old control mice   (MGI Ref ID J:99604)
    • at 4 and 6 months, mice show longer escape latencies in the first daily trial relative to the last trial of the previous training day indicating day-to-day retention impairment; 2-month old mice do not show this impairment in retention   (MGI Ref ID J:99604)
    • short- (1.5 hr posttraining) and long-term (24 hr posttraining) spatial recognition memory in probe trials are impaired at 6 months, whereas 4-month old mice show similar performance at 1.5 hours and impaired retention at 24 hours   (MGI Ref ID J:99604)
    • after clearance of intraneuronal Abeta using antibodies, early retention deficits are ablated, whereas long-term retention remains impaired   (MGI Ref ID J:99604)
    • abnormal contextual conditioning behavior
      • at 6 months, naive and trained mice display significantly impaired long- and short-term retention for contextual fear; at 4 months, mice have normal retention for short-term (1.5 hr) contextual fear but impaired memory of contextual fear at 24 hours   (MGI Ref ID J:99604)
  • nervous system phenotype
  • amyloid beta deposits
    • at 6 months, extracellular Abeta plaques are observed in the cerebral cortex, and intracellular accumulation is seen in pyramidal neurons of the CA1 region of hippocampus and within basolateral amygdala and cortical neurons   (MGI Ref ID J:99604)
    • prominent intraneuronal Abeta accumulation is present at 4 months, preceding extracellular amyloid plaque formation   (MGI Ref ID J:99604)
    • treatment of mice with antibodies to Abeta results in clearance of intraneuroanl Abeta in hippocampus and cortex, but not in amygdala   (MGI Ref ID J:99604)
  • homeostasis/metabolism phenotype
  • amyloid beta deposits
    • at 6 months, extracellular Abeta plaques are observed in the cerebral cortex, and intracellular accumulation is seen in pyramidal neurons of the CA1 region of hippocampus and within basolateral amygdala and cortical neurons   (MGI Ref ID J:99604)
    • prominent intraneuronal Abeta accumulation is present at 4 months, preceding extracellular amyloid plaque formation   (MGI Ref ID J:99604)
    • treatment of mice with antibodies to Abeta results in clearance of intraneuroanl Abeta in hippocampus and cortex, but not in amygdala   (MGI Ref ID J:99604)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Neurobiology Research
Alzheimer's Disease
      APP and PSEN1 mutants
      Presenilin mutants
      Tau (Mapt) mutants
      strains expressing mutant APP
Behavioral and Learning Defects

Research Tools
Neurobiology Research

MAPT related

Neurobiology Research
Parkinson's Disease

Psen1tm1Mpm related

Developmental Biology Research
Neurodevelopmental Defects
Postnatal Lethality
      Homozygous
Skeletal Defects

Neurobiology Research
Alzheimer's Disease
Behavioral and Learning Defects
Neurodegeneration
Neurodevelopmental Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Psen1tm1Mpm
Allele Name targeted mutation 1, Mark P Mattson
Allele Type Targeted
Common Name(s) PS-1 M146V KI; PS1KI; PS1M146V; PS1M146VKI-;
Mutation Made By George Martin,   University of Washington
Strain of Origin(129X1/SvJ x 129S1/Sv)F1-Kitl<+>
ES Cell Line NameR1
ES Cell Line Strain(129X1/SvJ x 129S1/Sv)F1-Kitl<+>
Promoter Psen1, presenilin 1, mouse, laboratory
Molecular Note Point mutations were introduced into the coding region of exon 5 that altered the codons corresponding to amino acids 145 and 146 from isoleucine and methionine to valine and valine, respectively. A lox-P flanked neomycin cassette was also introduced into exon 4. F2 mice exhibited the expected polymorphism of the targeted allele when genomic DNA was amplified with exon 5 specific primers and the products were digested with the appropriate restriction enzyme. Northern blot analysis of total brain RNA using a Psen1 specific antibody showed that the targeted allele was expressed at normal physiological levels in homozygous mutant mice. [MGI Ref ID J:51950]
 
Allele Symbol Tg(APPSwe,tauP301L)1Lfa
Allele Name transgene insertion 1, Frank M LaFerla
Allele Type Transgenic (Inserted expressed sequence)
Expressed Gene APP, amyloid beta (A4) precursor protein, human
Expressed Gene MAPT, microtubule-associated protein tau, human
Promoter Thy1, thymus cell antigen 1, theta, mouse, laboratory
Molecular Note To develop a model of Alzheimer's Disease, mice harboring mutant human APP (Swedish double mutation; K670N, M671L) and MAPT (P301L) as well as Psentm1Mpm were generated by microinjection of the APP and MAPT transgenic constructs into single cell embryos harvested from mice homozygous for Psen1tm1Mpm. Southern blot analysis indicated that both transgenic constructs integrated into the same site. Western blot analysis showed APP and MAPT levels to be ~4 fold higher in hemizygous mice and ~6 (APP) to ~7 (Mapt) fold higher homozygous mice, relative to non transgenic mice. Amyloid-Beta peptide (both 40 and 42) was detected in transgenic mice, with greater levels in homozygous mice than in hemizygous mice. Expression was confined to the CNS. Highest steady state levels of proteins were detected in Alzheimer's Disease related regions including the hippocampus and cerebral cortex. Transgenic protein was not detected in the cerebellum. [MGI Ref ID J:84847]
 
 
 

Genotyping

Genotyping Information

Genotyping Protocols

Generic App QPCR, QPCR
Psen1tm1Mpm, Pyrosequencing
Psen1tm1Mpm-EP, End Point Analysis
Tg(TAU*P301S)#Elan, Melt Curve Analysis
Generic Tg(APP), Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Oddo S; Caccamo A; Shepherd JD; Murphy MP; Golde TE; Kayed R; Metherate R; Mattson MP; Akbari Y; LaFerla FM. 2003. Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron 39(3):409-21. [PubMed: 12895417]  [MGI Ref ID J:84847]

Additional References

Psen1tm1Mpm related

Adebakin A; Bradley J; Gumusgoz S; Waters EJ; Lawrence CB. 2012. Impaired satiation and increased feeding behaviour in the triple-transgenic Alzheimer's disease mouse model. PLoS One 7(10):e45179. [PubMed: 23056194]  [MGI Ref ID J:192107]

Algarzae N; Hebron M; Miessau M; Moussa CE. 2012. Parkin prevents cortical atrophy and Abeta-induced alterations of brain metabolism: (1)(3)C NMR and magnetic resonance imaging studies in AD models. Neuroscience 225:22-34. [PubMed: 22960314]  [MGI Ref ID J:192478]

Alvarado-Martinez R; Salgado-Puga K; Pena-Ortega F. 2013. Amyloid beta inhibits olfactory bulb activity and the ability to smell. PLoS One 8(9):e75745. [PubMed: 24086624]  [MGI Ref ID J:206016]

Arsenault D; Dal-Pan A; Tremblay C; Bennett DA; Guitton MJ; De Koninck Y; Tonegawa S; Calon F. 2013. PAK inactivation impairs social recognition in 3xTg-AD Mice without increasing brain deposition of tau and Abeta. J Neurosci 33(26):10729-40. [PubMed: 23804095]  [MGI Ref ID J:199637]

Arsenault D; Julien C; Tremblay C; Calon F. 2011. DHA improves cognition and prevents dysfunction of entorhinal cortex neurons in 3xTg-AD mice. PLoS One 6(2):e17397. [PubMed: 21383850]  [MGI Ref ID J:171054]

Attar A; Liu T; Chan WT; Hayes J; Nejad M; Lei K; Bitan G. 2013. A shortened Barnes maze protocol reveals memory deficits at 4-months of age in the triple-transgenic mouse model of Alzheimer's disease. PLoS One 8(11):e80355. [PubMed: 24236177]  [MGI Ref ID J:209208]

Badiola N; Alcalde V; Pujol A; Munter LM; Multhaup G; Lleo A; Coma M; Soler-Lopez M; Aloy P. 2013. The proton-pump inhibitor lansoprazole enhances amyloid beta production. PLoS One 8(3):e58837. [PubMed: 23520537]  [MGI Ref ID J:200185]

Baeta-Corral R; Gimenez-Llort L. 2014. Bizarre behaviors and risk assessment in 3xTg-AD mice at early stages of the disease. Behav Brain Res 258:97-105. [PubMed: 24144550]  [MGI Ref ID J:207948]

Baglietto-Vargas D; Kitazawa M; Le EJ; Estrada-Hernandez T; Rodriguez-Ortiz CJ; Medeiros R; Green KN; LaFerla FM. 2014. Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition. Neurobiol Dis 62:407-15. [PubMed: 24176788]  [MGI Ref ID J:207203]

Banaceur S; Banasr S; Sakly M; Abdelmelek H. 2013. Whole body exposure to 2.4 GHz WIFI signals: effects on cognitive impairment in adult triple transgenic mouse models of Alzheimer's disease (3xTg-AD). Behav Brain Res 240:197-201. [PubMed: 23195115]  [MGI Ref ID J:197070]

Barak B; Shvarts-Serebro I; Modai S; Gilam A; Okun E; Michaelson DM; Mattson MP; Shomron N; Ashery U. 2013. Opposing actions of environmental enrichment and Alzheimer's disease on the expression of hippocampal microRNAs in mouse models. Transl Psychiatry 3:e304. [PubMed: 24022509]  [MGI Ref ID J:202026]

Barron AM; Rosario ER; Elteriefi R; Pike CJ. 2013. Sex-specific effects of high fat diet on indices of metabolic syndrome in 3xTg-AD mice: implications for Alzheimer's disease. PLoS One 8(10):e78554. [PubMed: 24205258]  [MGI Ref ID J:209228]

Billings LM; Oddo S; Green KN; McGaugh JL; Laferla FM. 2005. Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice. Neuron 45(5):675-88. [PubMed: 15748844]  [MGI Ref ID J:99604]

Bittner T; Fuhrmann M; Burgold S; Ochs SM; Hoffmann N; Mitteregger G; Kretzschmar H; LaFerla FM; Herms J. 2010. Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice. PLoS One 5(11):e15477. [PubMed: 21103384]  [MGI Ref ID J:166981]

Blaney CE; Gunn RK; Stover KR; Brown RE. 2013. Maternal genotype influences behavioral development of 3xTg-AD mouse pups. Behav Brain Res 252C:40-48. [PubMed: 23711927]  [MGI Ref ID J:199110]

Blurton-Jones M; Kitazawa M; Martinez-Coria H; Castello NA; Muller FJ; Loring JF; Yamasaki TR; Poon WW; Green KN; LaFerla FM. 2009. Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease. Proc Natl Acad Sci U S A 106(32):13594-9. [PubMed: 19633196]  [MGI Ref ID J:152002]

Boeras DI; Granic A; Padmanabhan J; Crespo NC; Rojiani AM; Potter H. 2008. Alzheimer's presenilin 1 causes chromosome missegregation and aneuploidy. Neurobiol Aging 29(3):319-28. [PubMed: 17169464]  [MGI Ref ID J:135054]

Bories C; Guitton MJ; Julien C; Tremblay C; Vandal M; Msaid M; De Koninck Y; Calon F. 2012. Sex-dependent alterations in social behaviour and cortical synaptic activity coincide at different ages in a model of Alzheimer's disease. PLoS One 7(9):e46111. [PubMed: 23029404]  [MGI Ref ID J:191965]

Born HA; Kim JY; Savjani RR; Das P; Dabaghian YA; Guo Q; Yoo JW; Schuler DR; Cirrito JR; Zheng H; Golde TE; Noebels JL; Jankowsky JL. 2014. Genetic suppression of transgenic APP rescues Hypersynchronous network activity in a mouse model of Alzeimer's disease. J Neurosci 34(11):3826-40. [PubMed: 24623762]  [MGI Ref ID J:209607]

Bryleva EY; Rogers MA; Chang CC; Buen F; Harris BT; Rousselet E; Seidah NG; Oddo S; LaFerla FM; Spencer TA; Hickey WF; Chang TY. 2010. ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD. Proc Natl Acad Sci U S A 107(7):3081-6. [PubMed: 20133765]  [MGI Ref ID J:157545]

Caccamo A; Maldonado MA; Bokov AF; Majumder S; Oddo S. 2010. CBP gene transfer increases BDNF levels and ameliorates learning and memory deficits in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A 107(52):22687-92. [PubMed: 21149712]  [MGI Ref ID J:167287]

Caccamo A; Maldonado MA; Majumder S; Medina DX; Holbein W; Magri A; Oddo S. 2011. Naturally Secreted Amyloid-{beta} Increases Mammalian Target of Rapamycin (mTOR) Activity via a PRAS40-mediated Mechanism. J Biol Chem 286(11):8924-32. [PubMed: 21266573]  [MGI Ref ID J:170949]

Caccamo A; Oddo S; Billings LM; Green KN; Martinez-Coria H; Fisher A; LaFerla FM. 2006. M1 receptors play a central role in modulating AD-like pathology in transgenic mice. Neuron 49(5):671-82. [PubMed: 16504943]  [MGI Ref ID J:107582]

Carvalho C; Cardoso S; Correia SC; Santos RX; Santos MS; Baldeiras I; Oliveira CR; Moreira PI. 2012. Metabolic alterations induced by sucrose intake and Alzheimer's disease promote similar brain mitochondrial abnormalities. Diabetes 61(5):1234-42. [PubMed: 22427376]  [MGI Ref ID J:196853]

Cassano T; Romano A; Macheda T; Colangeli R; Cimmino CS; Petrella A; Laferla FM; Cuomo V; Gaetani S. 2011. Olfactory memory is impaired in a triple transgenic model of Alzheimer disease. Behav Brain Res 224(2):408-12. [PubMed: 21741995]  [MGI Ref ID J:175693]

Cassano T; Serviddio G; Gaetani S; Romano A; Dipasquale P; Cianci S; Bellanti F; Laconca L; Romano AD; Padalino I; LaFerla FM; Nicoletti F; Cuomo V; Vendemiale G. 2012. Glutamatergic alterations and mitochondrial impairment in a murine model of Alzheimer disease. Neurobiol Aging 33(6):1121.e1-12. [PubMed: 22035587]  [MGI Ref ID J:188184]

Castello NA; Green KN; LaFerla FM. 2012. Genetic knockdown of brain-derived neurotrophic factor in 3xTg-AD mice does not alter Abeta or tau pathology. PLoS One 7(8):e39566. [PubMed: 22870188]  [MGI Ref ID J:189666]

Chakravarthy B; Gaudet C; Menard M; Atkinson T; Chiarini A; Dal Pra I; Whitfield J. 2010. The p75 neurotrophin receptor is localized to primary cilia in adult murine hippocampal dentate gyrus granule cells. Biochem Biophys Res Commun 401(3):458-62. [PubMed: 20875398]  [MGI Ref ID J:166163]

Chakravarthy B; Gaudet C; Menard M; Brown L; Atkinson T; Laferla FM; Ito S; Armato U; Dal Pra I; Whitfield J. 2012. Reduction of the immunostainable length of the hippocampal dentate granule cells' primary cilia in 3xAD-transgenic mice producing human Abeta(1-42) and tau. Biochem Biophys Res Commun 427(1):218-22. [PubMed: 22995307]  [MGI Ref ID J:190096]

Chakravarthy B; Menard M; Brown L; Hewitt M; Atkinson T; Whitfield J. 2013. A synthetic peptide corresponding to a region of the human pericentriolar material 1 (PCM-1) protein binds beta-amyloid (Abeta1-42 ) oligomers. J Neurochem 126(3):415-24. [PubMed: 23432034]  [MGI Ref ID J:199628]

Chakroborty S; Briggs C; Miller MB; Goussakov I; Schneider C; Kim J; Wicks J; Richardson JC; Conklin V; Cameransi BG; Stutzmann GE. 2012. Stabilizing ER Ca2+ channel function as an early preventative strategy for Alzheimer's disease. PLoS One 7(12):e52056. [PubMed: 23284867]  [MGI Ref ID J:195625]

Chakroborty S; Goussakov I; Miller MB; Stutzmann GE. 2009. Deviant ryanodine receptor-mediated calcium release resets synaptic homeostasis in presymptomatic 3xTg-AD mice. J Neurosci 29(30):9458-70. [PubMed: 19641109]  [MGI Ref ID J:151323]

Chan SL; Culmsee C; Haughey N; Klapper W; Mattson MP. 2002. Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12. Neurobiol Dis 11(1):2-19. [PubMed: 12460542]  [MGI Ref ID J:125448]

Chan SL; Mayne M; Holden CP; Geiger JD; Mattson MP. 2000. Presenilin-1 mutations increase levels of ryanodine receptors and calcium release in PC12 cells and cortical neurons. J Biol Chem 275(24):18195-200. [PubMed: 10764737]  [MGI Ref ID J:62820]

Chen S; Wang JM; Irwin RW; Yao J; Liu L; Brinton RD. 2011. Allopregnanolone Promotes Regeneration and Reduces beta-Amyloid Burden in a Preclinical Model of Alzheimer's Disease. PLoS One 6(8):e24293. [PubMed: 21918687]  [MGI Ref ID J:176128]

Chen Y; Tian Z; Liang Z; Sun S; Dai CL; Lee MH; LaFerla FM; Grundke-Iqbal I; Iqbal K; Liu F; Gong CX. 2012. Brain gene expression of a sporadic (icv-STZ Mouse) and a familial mouse model (3xTg-AD mouse) of Alzheimer's disease. PLoS One 7(12):e51432. [PubMed: 23236499]  [MGI Ref ID J:195677]

Cheung KH; Mei L; Mak DO; Hayashi I; Iwatsubo T; Kang DE; Foskett JK. 2010. Gain-of-function enhancement of IP3 receptor modal gating by familial Alzheimer's disease-linked presenilin mutants in human cells and mouse neurons. Sci Signal 3(114):ra22. [PubMed: 20332427]  [MGI Ref ID J:185414]

Chu J; Li JG; Pratico D. 2013. Zileuton improves memory deficits, amyloid and tau pathology in a mouse model of Alzheimer's disease with plaques and tangles. PLoS One 8(8):e70991. [PubMed: 23951061]  [MGI Ref ID J:205889]

Chu TH; Yang CC; Liu CJ; Lui MT; Lin SC; Chang KW. 2013. miR-211 promotes the progression of head and neck carcinomas by targeting TGFbetaRII. Cancer Lett 337(1):115-24. [PubMed: 23726841]  [MGI Ref ID J:199100]

Clinton LK; Billings LM; Green KN; Caccamo A; Ngo J; Oddo S; McGaugh JL; LaFerla FM. 2007. Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice. Neurobiol Dis 28(1):76-82. [PubMed: 17659878]  [MGI Ref ID J:134819]

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Tg(APPSwe,tauP301L)1Lfa related

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Algarzae N; Hebron M; Miessau M; Moussa CE. 2012. Parkin prevents cortical atrophy and Abeta-induced alterations of brain metabolism: (1)(3)C NMR and magnetic resonance imaging studies in AD models. Neuroscience 225:22-34. [PubMed: 22960314]  [MGI Ref ID J:192478]

Alvarado-Martinez R; Salgado-Puga K; Pena-Ortega F. 2013. Amyloid beta inhibits olfactory bulb activity and the ability to smell. PLoS One 8(9):e75745. [PubMed: 24086624]  [MGI Ref ID J:206016]

Arsenault D; Dal-Pan A; Tremblay C; Bennett DA; Guitton MJ; De Koninck Y; Tonegawa S; Calon F. 2013. PAK inactivation impairs social recognition in 3xTg-AD Mice without increasing brain deposition of tau and Abeta. J Neurosci 33(26):10729-40. [PubMed: 23804095]  [MGI Ref ID J:199637]

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Bryleva EY; Rogers MA; Chang CC; Buen F; Harris BT; Rousselet E; Seidah NG; Oddo S; LaFerla FM; Spencer TA; Hickey WF; Chang TY. 2010. ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD. Proc Natl Acad Sci U S A 107(7):3081-6. [PubMed: 20133765]  [MGI Ref ID J:157545]

Caccamo A; Maldonado MA; Bokov AF; Majumder S; Oddo S. 2010. CBP gene transfer increases BDNF levels and ameliorates learning and memory deficits in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A 107(52):22687-92. [PubMed: 21149712]  [MGI Ref ID J:167287]

Caccamo A; Maldonado MA; Majumder S; Medina DX; Holbein W; Magri A; Oddo S. 2011. Naturally Secreted Amyloid-{beta} Increases Mammalian Target of Rapamycin (mTOR) Activity via a PRAS40-mediated Mechanism. J Biol Chem 286(11):8924-32. [PubMed: 21266573]  [MGI Ref ID J:170949]

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Caccamo A; Oddo S; Tran LX; Laferla FM. 2007. Lithium Reduces Tau Phosphorylation but Not A{beta} or Working Memory Deficits in a Transgenic Model with Both Plaques and Tangles. Am J Pathol 170(5):1669-78. [PubMed: 17456772]  [MGI Ref ID J:121081]

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Caruso D; Barron AM; Brown MA; Abbiati F; Carrero P; Pike CJ; Garcia-Segura LM; Melcangi RC. 2013. Age-related changes in neuroactive steroid levels in 3xTg-AD mice. Neurobiol Aging 34(4):1080-9. [PubMed: 23122920]  [MGI Ref ID J:203381]

Carvalho C; Cardoso S; Correia SC; Santos RX; Santos MS; Baldeiras I; Oliveira CR; Moreira PI. 2012. Metabolic alterations induced by sucrose intake and Alzheimer's disease promote similar brain mitochondrial abnormalities. Diabetes 61(5):1234-42. [PubMed: 22427376]  [MGI Ref ID J:196853]

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Robertson RT; Baratta J; Yu J; LaFerla FM. 2009. Amyloid-beta expression in retrosplenial cortex of triple transgenic mice: relationship to cholinergic axonal afferents from medial septum. Neuroscience 164(3):1334-46. [PubMed: 19772895]  [MGI Ref ID J:155135]

Rodriguez JJ; Jones VC; Tabuchi M; Allan SM; Knight EM; LaFerla FM; Oddo S; Verkhratsky A. 2008. Impaired adult neurogenesis in the dentate gyrus of a triple transgenic mouse model of Alzheimer's disease. PLoS ONE 3(8):e2935. [PubMed: 18698410]  [MGI Ref ID J:140591]

Rodriguez JJ; Noristani HN; Hilditch T; Olabarria M; Yeh CY; Witton J; Verkhratsky A. 2013. Increased densities of resting and activated microglia in the dentate gyrus follow senile plaque formation in the CA1 subfield of the hippocampus in the triple transgenic model of Alzheimer's disease. Neurosci Lett 552:129-34. [PubMed: 23827221]  [MGI Ref ID J:201677]

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Rohn TT; Vyas V; Hernandez-Estrada T; Nichol KE; Christie LA; Head E. 2008. Lack of pathology in a triple transgenic mouse model of Alzheimer's disease after overexpression of the anti-apoptotic protein Bcl-2. J Neurosci 28(12):3051-9. [PubMed: 18354008]  [MGI Ref ID J:133211]

Romberg C; Mattson MP; Mughal MR; Bussey TJ; Saksida LM. 2011. Impaired attention in the 3xTgAD mouse model of Alzheimer's disease: rescue by donepezil (Aricept). J Neurosci 31(9):3500-7. [PubMed: 21368062]  [MGI Ref ID J:170670]

Rosario ER; Carroll J; Pike CJ. 2010. Testosterone regulation of Alzheimer-like neuropathology in male 3xTg-AD mice involves both estrogen and androgen pathways. Brain Res 1359:281-90. [PubMed: 20807511]  [MGI Ref ID J:166622]

Rosario ER; Carroll JC; Oddo S; LaFerla FM; Pike CJ. 2006. Androgens regulate the development of neuropathology in a triple transgenic mouse model of Alzheimer's disease. J Neurosci 26(51):13384-9. [PubMed: 17182789]  [MGI Ref ID J:116683]

Rosario ER; Carroll JC; Pike CJ. 2012. Evaluation of the effects of testosterone and luteinizing hormone on regulation of beta-amyloid in male 3xTg-AD mice. Brain Res 1466:137-45. [PubMed: 22587890]  [MGI Ref ID J:186440]

Rothman SM; Herdener N; Camandola S; Texel SJ; Mughal MR; Cong WN; Martin B; Mattson MP. 2012. 3xTgAD mice exhibit altered behavior and elevated Abeta after chronic mild social stress. Neurobiol Aging 33(4):830.e1-12. [PubMed: 21855175]  [MGI Ref ID J:188192]

Sancheti H; Akopian G; Yin F; Brinton RD; Walsh JP; Cadenas E. 2013. Age-dependent modulation of synaptic plasticity and insulin mimetic effect of lipoic acid on a mouse model of Alzheimer's disease. PLoS One 8(7):e69830. [PubMed: 23875003]  [MGI Ref ID J:204388]

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Shilling D; Muller M; Takano H; Mak DO; Abel T; Coulter DA; Foskett JK. 2014. Suppression of InsP3 receptor-mediated Ca2+ signaling alleviates mutant presenilin-linked familial Alzheimer's disease pathogenesis. J Neurosci 34(20):6910-23. [PubMed: 24828645]  [MGI Ref ID J:211264]

Singh C; Liu L; Wang JM; Irwin RW; Yao J; Chen S; Henry S; Thompson RF; Brinton RD. 2012. Allopregnanolone restores hippocampal-dependent learning and memory and neural progenitor survival in aging 3xTgAD and nonTg mice. Neurobiol Aging 33(8):1493-506. [PubMed: 21803451]  [MGI Ref ID J:188197]

Smith IF; Hitt B; Green KN; Oddo S; LaFerla FM. 2005. Enhanced caffeine-induced Ca2+ release in the 3xTg-AD mouse model of Alzheimer's disease. J Neurochem 94(6):1711-8. [PubMed: 16156741]  [MGI Ref ID J:101318]

Song JM; DiBattista AM; Sung YM; Ahn JM; Turner RS; Yang J; Pak DT; Lee HK; Hoe HS. 2014. A tetra(ethylene glycol) derivative of benzothiazole aniline ameliorates dendritic spine density and cognitive function in a mouse model of Alzheimer's disease. Exp Neurol 252:105-13. [PubMed: 24316432]  [MGI Ref ID J:210695]

Sterniczuk R; Antle MC; Laferla FM; Dyck RH. 2010. Characterization of the 3xTg-AD mouse model of Alzheimer's disease: part 2. Behavioral and cognitive changes. Brain Res 1348:149-55. [PubMed: 20558146]  [MGI Ref ID J:163336]

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Stutzmann GE; Smith I; Caccamo A; Oddo S; Laferla FM; Parker I. 2006. Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young, adult, and aged Alzheimer's disease mice. J Neurosci 26(19):5180-9. [PubMed: 16687509]  [MGI Ref ID J:108684]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX12

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, mice that are homozygous for the Psen1 mutation and homozygous for the co-injected APPSwe and tauP301L transgenes (Tg(APPSwe,tauP301L)1Lfa) may be bred together.
Mating SystemSee Colony Maintenance under the Health & Care tab         (Female x Male)   28-OCT-13
Diet Information New Diet as of April 7, 2014: Lab Diet® 5K0Q

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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