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Former Name	C57BL/6J-Kcne1nmf190/J    (Changed: 15-DEC-04 )
	C57BL/6J-nmf190/J    (Changed: 15-DEC-04 )
	NMF190    (Changed: 15-DEC-04 )
Genes & Alleles	Cdh23;   Cdh23ahl;   Kcne1;   Kcne12J;

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Product Information

Strain Details

Type JAX® GEMM® Strain - Chemically Induced Mutation Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Coisogenic Type JAX® GEMM® Strain - Mutant Strain Species laboratory mouse H2 Haplotype b

Appearance
black
Related Genotype: a/a

Important Note
The C57BL/6J background strain is homozygous for the age related hearing loss mutation Cdh23^ahl, which on this background causes progressive hearing loss with onset after 10 months of age.

Strain Description
View strain phenotype and additional information on the Neuroscience Mutagenesis Facility web page for Kcne1^2J entry.

Mammalian Phenotype Terms assigned by genotype Kcne12J/Kcne12J         C57BL/6J-Kcne12J/J behavior/neurological phenotype head bobbing (J:82238) discernable by weaning age head tilt (J:82238) discernable by weaning age hearing/vestibular/ear phenotype abnormal brainstem auditory evoked potential (J:82238) deafness (J:82238) one mutant was subject to testing by ABR and found to be deaf head bobbing (J:82238) discernable by weaning age head tilt (J:82238) discernable by weaning age

Gene & Allele Details

Allele Symbol		Kcne12J
Allele Name		2 Jackson
Common Name(s)		Kcne1nmf190; NMF190; neuroscience mutagenesis facility, 190;
Strain of Origin		C57BL/6J
Gene Symbol and Name		Kcne1, potassium voltage-gated channel, Isk-related subfamily, member 1
Chromosome		16
Gene Common Name(s)		ISK; JLNS; JLNS2; LQT5; MGC33114; MinK; m; neuroscience mutagenesis facility, 190; nmf190;
Molecular Note		This phenotypic mutant was identified in an ENU mutagenesis screen. Complemetation tests demonstrated that this mutation is an allele of Kcne1.
Allele Symbol		Cdh23ahl
Allele Name		age related hearing loss 1
Common Name(s)		Cdh23753A; mdfw;

Control Information

Allele	Control
Kcne12J	Untyped from the colony
Considerations for Choosing Controls

Related Strains

Strains carrying   Cdh23^ahl allele

001137	129P1/ReJ
000690	129P3/J
002065	129T2/SvEmsJ
000691	129X1/SvJ
000646	A/J
000647	A/WySnJ
003070	ALR/LtJ
003072	ALS/LtJ
004502	B6;AKR-Lxl2/J
001026	BALB/cByJ
000653	BUB/BnJ
005494	C3.129S1(B6)-Grm1rcw/J
000664	C57BL/6J
004764	C57BL/6J-Cdh23v-8J/J
003129	C57BL/6J-Epha4rb-2J/J
004703	C57BL/6J-Nmf134/J
004811	C57BL/6J-nmf110/J
004812	C57BL/6J-nmf111/J
004747	C57BL/6J-nmf118/J
004656	C57BL/6J-nmf88/J
004391	C57BL/6J-Chr 13A/J/NaJ
004385	C57BL/6J-Chr 7A/J/NaJ
000662	C57BLKS/J
000667	C57BR/cdJ
000668	C57L/J
000669	C58/J
000657	CE/J
000670	DBA/1J
001140	DBA/1LacJ
000671	DBA/2J
007048	DBA/2J-Gpnmb+/SjJ
002106	KK/HlJ
000675	LG/J
000676	LP/J
000677	MA/MyJ
001976	NOD/ShiLtJ
002050	NOR/LtJ
000679	P/J
002747	SENCARB/PtJ
002335	SKH2/J
003392	STOCK Crb1rd8/J

View Strains carrying   Cdh23^ahl     (41 strains)

Strains carrying other alleles of Cdh23

002756	B6.CAST-Cdh23Ahl+/Kjn
002432	B6J x B6.C-H2bm1/ByJ-Cdh23v-J/J
002552	C57BL/6J-Cdh23v-2J/J
004764	C57BL/6J-Cdh23v-8J/J
004819	C57BL/6J-Cdh23v-9J/J
005016	CByJ;B6-Cdh23v-10J/J
000275	V/LeJ

View Strains carrying other alleles of Cdh23     (7 strains)

Strains carrying other alleles of Kcne1

003009

129-Kcne1tm1Sfh/J

View Strains carrying other alleles of Kcne1     (1 strain)

Research Applications

This mouse can be used to support research in many areas including:

Cdh23^ahl related

Neurobiology Research
Vestibular and Hearing Defects (Age related hearing loss)

Sensorineural Research
Vestibular and Hearing Defects (Age related hearing loss)

Kcne1^2J related

Cell Biology Research
Channel and Transporter Defects (potassium)

Neurobiology Research
Channel and Transporter Defects (potassium)
Neuroscience Mutagenesis Facility Strain
Vestibular and Hearing Defects

References

Additional References

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Price and Supply Information

Strain Name:	C57BL/6J-Kcne12J/J
Stock Number:	004820

Price Details

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Supply Details

Standard Supply	Repository-Cryopreserved. Must Be Recovered. Please refer to the Supply Notes for further information.
Supply Notes	Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services: Tel: 800-422-6423 or 207-288-5845; Email: jaxservices@jax.org. This strain is included in the Neuroscience Mutagenesis Facility (NMF).
Licensing	See General Terms and Conditions below
Control Information	View Control Information in Strain Details.

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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