JAX Mice Database - 004828 FVB.129P2-Pde6b<+> Tyr<c-ch>/AntJ

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Strain Name:	FVB.129P2-Pde6b⁺ Tyr^c-ch/AntJ
Stock Number:	004828
Availability:	Repository- Live

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General Terms and Conditions

Genes & Alleles

Pde6b; Pde6b⁺; Tyr; Tyr^c-ch;

Product Information

Strain Details

Type JAX^® GEMM^® Strain - Congenic

Additional information on JAX^® GEMM^® Strains.

Type JAX^® GEMM^® Strain - Mutant Strain

Mating System Homozygote x Homozygote (Female x Male)

Species laboratory mouse

Donating Investigator IMR Colony, The Jackson Laboratory

Generation N11+N1F10 (05-DEC-07)

Strain Description
These mice are homozygous for the 129P2/OlaHsd wildtype Pde6b allele and do not suffer from blindness due to retinal degeneration. Mice from the colony of FVB.129P2-Fmr1 ^tm1Cgr, Stock # 4624, that no longer carried the mutant allele for Fmr1 were used to establish this line. Mice are pigmented as a result of the homozygosity of the Tyr^c-ch allele. This mutant mouse strain may be useful in studies where a sighted mouse on the FVB background is an appropriate control, such as behavioral studies. This strain serves as the control for the FVB.129P2-Fmr1 ^tm1Cgr strain, Stock # 4624.
Strain Development
This strain originated on a FVB;129P2 background, was backcrossed for 11 generations on the FVB background. ( Please refer to Strain Development for Stock#4624 for details.) Mice from the colony of FVB.129P2-Fmr1 ^tm1Cgr, Stock # 4624, that no longer carried the mutant allele for Fmr1 and carried the 129P2/OlaHsd wildtype Pde6b allele were used to establish this line.

Mammalian Phenotype Terms assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX^® Mice strain.
Tyr^c-ch/Tyr^c-ch
Background Not Specified
pigmentation phenotype

diluted coat color (J:6611)

mice have a grey coat color

the amount of melanin found in anagen hairbulbs is reduced by more than 30% compared to wild-type mice

skin/coat/nails phenotype

diluted coat color (J:6611)

mice have a grey coat color

the amount of melanin found in anagen hairbulbs is reduced by more than 30% compared to wild-type mice

Gene & Allele Details

Allele Symbol		Pde6b⁺
Allele Name		wild type
Mutation Made By		Frank Kooy, University of Antwerp
Gene Symbol and Name		Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
Chromosome		5
Gene Common Name(s)		CSNB3; PDEB; Pdeb; RP40; nmf137; phosphodiesterase, cGMP, rod receptor, beta polypeptide; r; rd; rd-1; rd1; rd10; retinal degeneration; retinal degeneration 1; retinal degeneration 10;

Allele Symbol		Tyr^c-ch
Allele Name		chinchilla
Common Name(s)		c^ch; c^r;
Strain of Origin		fancier's stock
Gene Symbol and Name		Tyr, tyrosinase
Chromosome		7
Gene Common Name(s)		C; OCA1A; OCAIA; SHEP3; albino; c; skc35; skin/coat color 35;
Molecular Note		The mutation in the chinchilla allele was found to be a G to A point mutation that results in an amino acid change at position 464 from alanine to threonine. [J:19279]

Control Information

	Control
	None Available

Considerations for Choosing Controls

Genotyping Protocols

Pde6b^rd1

Colony Maintenance

Breeding & Husbandry	This strain originated on a FVB;129P2 background, and was backcrossed for 11 generations on the FVB background.
Diet Information	LabDiet® 5K52/5K67

Related Strains

Strains carrying Pde6b⁺ allele

002802 C3.BLiA Pde6b⁺-Krd/J

001979 C3A.BLiA-Pde6b⁺.O20-Prph2^Rd2/J

001912 C3A.BLiA-Pde6b⁺/J

003648 C3Sn.BLiA-Pde6b⁺/Dn

004808 STOCK Mapt^tm1(EGFP)Klt Tg(MAPT)8cPdav/J

View Strains carrying Pde6b⁺ (5 strains)

Strains carrying Tyr^c-ch allele

000091 129T1/Sv-Oca2⁺ Tyr^c-ch Dnd1^Ter/J

001279 129T1/Sv-Oca2⁺ Tyr^c-ch-Aft/J

000578 B6 x STOCK Tyr^c-ch Bmp5^se +/+ Myo6^sv/J

000619 FS/EiJ

000271 SH1/LeJ

000306 STOCK Dll3^pu + Tyr^c-ch/+ Oca2^p Tyr^c-ch/J

View Strains carrying Tyr^c-ch (6 strains)

Strains carrying other alleles of Pde6b

004202 B6.C3 Pde6b^rd1 Hps4^le/+ +-Lmx1a^dr-8J/J

000002 B6.C3-Pde6b^rd1 Hps4^le/J

004297 B6.CXB1-Pde6b^rd10/J

001022 B6C3FeF1/J a/a

000652 BDP/J

000653 BUB/BnJ

002439 C3.129P2(B6)-B2m^tm1Unc/J

005494 C3.129S1(B6)-Grm1^rcw/J

000480 C3.MRL-Fas^lpr/J

001957 C3A Pde6b^rd1.O20/A-Prph2^Rd2/J

005973 C3Bir.129P2(B6)-Il10^C3Bir/LtJ

004326 C3Bir.129P2(B6)-Il10^tm1Cgn/Lt

003968 C3Bir.129P2(B6)-Il10^tm1Cgn/LtJ

001906 C3Ga.Cg-Cat^b/J

001904 C3H-Atcay^ji-hes/J

000659 C3H/HeJ

000784 C3H/HeJ-Fasl^gld/J

000509 C3H/HeJ-Lyst^bg-2J/J

002433 C3H/HeJ-Spnb4^qv-lnd2J/J

005972 C3H/HeJBirLtJ

001824 C3H/HeJSxJ

000635 C3H/HeOuJ

000474 C3H/HeSn

001431 C3H/HeSn-ocd/J

000661 C3H/HeSnJ

002235 C3H/HeSnJ-Ctnna2^cdf/J

002333 C3H/HeSnJ-gri/J

006435 C3HeB.SW-Soa^a/MonJ

000658 C3HeB/FeJ

001576 C3HeB/FeJ-Atp7b^tx-J/J

002588 C3HeB/FeJ-Eya1^bor/J

001533 C3HeB/FeJ-Mc1r^E-so Gli3^Xt-J/J

001886 C3HeB/FeJLe a/a-gnd/J

001908 C3HfB/BiJ

001502 C3Sn.B6-Epha4^rb/J

001547 C3Sn.Cg-Cm/J

004766 C57BL/6J-Pde6b^rd1-2J/J

000656 CBA/J

000813 CBA/J-Atp7a^Mo-pew/J

000660 DA/HuSnJ

000023 FL/1ReJ

000025 FL/4ReJ

003078 FVB-Tg(WapIgf1)39Dlr/J

003024 FVB.129P2(B6)-Fmr1^tm1Cgr/J

002539 FVB.129P2-Abcb4^tm1Bor/J

002935 FVB.129S2(B6)-Ccnd1^tm1Wbg/J

002953 FVB.Cg-Tg(MMTVTGFA)254Rjc/J

003170 FVB.Cg-Tg(Myh6-tTA)6Smbf/J

003257 FVB/N-Tg(GFAPGFP)14Mes/J

002374 FVB/N-Tg(MMTV-PyVT)634Mul/J

002856 FVB/N-Tg(TIE2-lacZ)182Sato/J

002384 FVB/N-Tg(UcpDta)1Kz/J

001800 FVB/NJ

003487 FVB/NJ-Tg(XGFAP-lacZ)3Mes/J

001491 FVB/NMob

000734 MOLD/RkJ

000550 MOLF/EiJ

002423 NON/ShiLtJ

000679 P/J

000680 PL/J

100299 PLSJLF1/J

000269 SB/LeJ

005651 SJL.AK-Thy1^a/TseJ

000686 SJL/J

000688 ST/bJ

004808 STOCK Mapt^tm1(EGFP)Klt Tg(MAPT)8cPdav/J

002648 STOCK a/a Cln6^nclf/J

000279 STOCK gr +/+ Ap3d1^mh/J

005965 STOCK Tg(Pomc1-cre)16Lowl/J

004770 SW.B6-Soa^b/J

002023 SWR.M-Emv21 Emv22/J

000689 SWR/J

000939 SWR/J-Clcn1^adr-mto/J

000692 WB/ReJ Kit^W/J

100410 WBB6F1/J-Kit^W/Kit^W-v/J

000693 WC/ReJ Kitl^Sl/J

100401 WCB6F1/J Kitl^Sl Kitl^Sl-d

View Strains carrying other alleles of Pde6b (77 strains)

Strains carrying other alleles of Tyr

000090 129S1/Sv-Oca2⁺ Tyr⁺ Kitl^Sl-J/J

005445 A.B6 Tyr⁺-Cyba^nmf333/J

005012 A.B6 Tyr⁺-Myo5a^d-l31J/J

002565 A.B6-Tyr⁺/J

000409 B10.129P-H1^b Hbb^d Tyr^c Ea7^a/(5M)oSnJ

000418 B10.129P-H1^b Tyr^c Hbb^d/(5M)nSnJ

000432 B10.C-H1^b Hbb^d Tyr^c/(41N)SnJ

000580 B10.D2/nSn-Tyr^c-4J/J

000822 B6 x 129S1/SvEi Oca2⁺ Tyr⁺-Vsx2^or-J/J

000058 B6(Cg)-Tyr^c-2J/J

000383 B6.C-Tyr^c H1^b Hbb^d/ByJ

007484 B6.Cg-Tyr^c-2J Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ

000035 B6.Cg-Tyr^c-J/J

000104 B6.Cg-Tyr^c-h/J

000054 B6.D2-Tyr^c-p/J

000899 C.B6-Tyr⁺ Hbb^s/J

000339 C3H/HeJ-Tyr^c-9J/J

001294 C3H/HeJ-Tyr^c-a/J

001002 C57BL/10SnJ-Tyr^c-11J/J

001006 CBA/J-Tyr^c-10J/J

000657 CE/J

007483 FVB.Cg-Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ

000494 J.Cg-Oca2⁺ Tyr⁺ Lyst^bg/J

002281 NFS.C58-Tyr⁺/J

004304 NOD.CBALs-Tyr⁺/LtJ

005115 NOD.FVB-Tg(INS-MT2A,Tyr)1Pne/PneJ

005114 NOD.FVB-Tg(Ins1-Cat,Tyr)25Pne/PneJ

001759 STOCK A Tyr^c Sha/J

000006 STOCK Hk Tyr^c/J

000206 STOCK a/a Tyr^c-h/J

View Strains carrying other alleles of Tyr (30 strains)

Additional Web Information

Congenic Nomenclature
Genetic Quality Control Annual Report

Animal Health Reports

Room Number AX12

Research Applications

This mouse can be used to support research in many areas including:

Pde6b⁺ related

Mouse/Human Gene Homologs
retinitis pigmentosa, wildtype

Sensorineural Research
Retinal Degeneration (wild-type)

Tyr^c-ch related

Dermatology Research
Color and White Spotting Defects

Developmental Biology Research
Neurodevelopmental Defects
Skeletal Defects

Mouse/Human Gene Homologs
albinism, tyrosine negative

References

Additional References

Price and Supply Information

Strain Name:	*FVB.129P2-Pde6b⁺ Tyr^c-ch/AntJ*
Stock Number:	004828

Price Details

IMPORTANT NOTE: Prices are based on shipping destination. To view prices, select your shipping destination.

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Supply Details

Standard Supply	Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.
Supply Notes	Usually shipped between four and eight weeks of age. This strain is included in the Induced Mutant Resource Colony collection. Genomic DNA is available for this strain from the Mouse DNA Resource.
Licensing	See General Terms and Conditions below
Control Information	View Control Information in Strain Details.

General Terms and Conditions

View JAX^® Mice & Services Conditions of Use.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

Ordering and Purchasing Information

Purchasing Information
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Contact Information
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Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form

Go to JAX^® Mice Query Form

002802	C3.BLiA Pde6b⁺-Krd/J
001979	C3A.BLiA-Pde6b⁺.O20-Prph2^Rd2/J
001912	C3A.BLiA-Pde6b⁺/J
003648	C3Sn.BLiA-Pde6b⁺/Dn
004808	STOCK Mapt^tm1(EGFP)Klt Tg(MAPT)8cPdav/J

000091	129T1/Sv-Oca2⁺ Tyr^c-ch Dnd1^Ter/J
001279	129T1/Sv-Oca2⁺ Tyr^c-ch-Aft/J
000578	B6 x STOCK Tyr^c-ch Bmp5^se +/+ Myo6^sv/J
000619	FS/EiJ
000271	SH1/LeJ
000306	STOCK Dll3^pu + Tyr^c-ch/+ Oca2^p Tyr^c-ch/J

004202	B6.C3 Pde6b^rd1 Hps4^le/+ +-Lmx1a^dr-8J/J
000002	B6.C3-Pde6b^rd1 Hps4^le/J
004297	B6.CXB1-Pde6b^rd10/J
001022	B6C3FeF1/J a/a
000652	BDP/J
000653	BUB/BnJ
002439	C3.129P2(B6)-B2m^tm1Unc/J
005494	C3.129S1(B6)-Grm1^rcw/J
000480	C3.MRL-Fas^lpr/J
001957	C3A Pde6b^rd1.O20/A-Prph2^Rd2/J
005973	C3Bir.129P2(B6)-Il10^C3Bir/LtJ
004326	C3Bir.129P2(B6)-Il10^tm1Cgn/Lt
003968	C3Bir.129P2(B6)-Il10^tm1Cgn/LtJ
001906	C3Ga.Cg-Cat^b/J
001904	C3H-Atcay^ji-hes/J
000659	C3H/HeJ
000784	C3H/HeJ-Fasl^gld/J
000509	C3H/HeJ-Lyst^bg-2J/J
002433	C3H/HeJ-Spnb4^qv-lnd2J/J
005972	C3H/HeJBirLtJ
001824	C3H/HeJSxJ
000635	C3H/HeOuJ
000474	C3H/HeSn
001431	C3H/HeSn-ocd/J
000661	C3H/HeSnJ
002235	C3H/HeSnJ-Ctnna2^cdf/J
002333	C3H/HeSnJ-gri/J
006435	C3HeB.SW-Soa^a/MonJ
000658	C3HeB/FeJ
001576	C3HeB/FeJ-Atp7b^tx-J/J
002588	C3HeB/FeJ-Eya1^bor/J
001533	C3HeB/FeJ-Mc1r^E-so Gli3^Xt-J/J
001886	C3HeB/FeJLe a/a-gnd/J
001908	C3HfB/BiJ
001502	C3Sn.B6-Epha4^rb/J
001547	C3Sn.Cg-Cm/J
004766	C57BL/6J-Pde6b^rd1-2J/J
000656	CBA/J
000813	CBA/J-Atp7a^Mo-pew/J
000660	DA/HuSnJ
000023	FL/1ReJ
000025	FL/4ReJ
003078	FVB-Tg(WapIgf1)39Dlr/J
003024	FVB.129P2(B6)-Fmr1^tm1Cgr/J
002539	FVB.129P2-Abcb4^tm1Bor/J
002935	FVB.129S2(B6)-Ccnd1^tm1Wbg/J
002953	FVB.Cg-Tg(MMTVTGFA)254Rjc/J
003170	FVB.Cg-Tg(Myh6-tTA)6Smbf/J
003257	FVB/N-Tg(GFAPGFP)14Mes/J
002374	FVB/N-Tg(MMTV-PyVT)634Mul/J
002856	FVB/N-Tg(TIE2-lacZ)182Sato/J
002384	FVB/N-Tg(UcpDta)1Kz/J
001800	FVB/NJ
003487	FVB/NJ-Tg(XGFAP-lacZ)3Mes/J
001491	FVB/NMob
000734	MOLD/RkJ
000550	MOLF/EiJ
002423	NON/ShiLtJ
000679	P/J
000680	PL/J
100299	PLSJLF1/J
000269	SB/LeJ
005651	SJL.AK-Thy1^a/TseJ
000686	SJL/J
000688	ST/bJ
004808	STOCK Mapt^tm1(EGFP)Klt Tg(MAPT)8cPdav/J
002648	STOCK a/a Cln6^nclf/J
000279	STOCK gr +/+ Ap3d1^mh/J
005965	STOCK Tg(Pomc1-cre)16Lowl/J
004770	SW.B6-Soa^b/J
002023	SWR.M-Emv21 Emv22/J
000689	SWR/J
000939	SWR/J-Clcn1^adr-mto/J
000692	WB/ReJ Kit^W/J
100410	WBB6F1/J-Kit^W/Kit^W-v/J
000693	WC/ReJ Kitl^Sl/J
100401	WCB6F1/J Kitl^Sl Kitl^Sl-d

000090	129S1/Sv-Oca2⁺ Tyr⁺ Kitl^Sl-J/J
005445	A.B6 Tyr⁺-Cyba^nmf333/J
005012	A.B6 Tyr⁺-Myo5a^d-l31J/J
002565	A.B6-Tyr⁺/J
000409	B10.129P-H1^b Hbb^d Tyr^c Ea7^a/(5M)oSnJ
000418	B10.129P-H1^b Tyr^c Hbb^d/(5M)nSnJ
000432	B10.C-H1^b Hbb^d Tyr^c/(41N)SnJ
000580	B10.D2/nSn-Tyr^c-4J/J
000822	B6 x 129S1/SvEi Oca2⁺ Tyr⁺-Vsx2^or-J/J
000058	B6(Cg)-Tyr^c-2J/J
000383	B6.C-Tyr^c H1^b Hbb^d/ByJ
007484	B6.Cg-Tyr^c-2J Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ
000035	B6.Cg-Tyr^c-J/J
000104	B6.Cg-Tyr^c-h/J
000054	B6.D2-Tyr^c-p/J
000899	C.B6-Tyr⁺ Hbb^s/J
000339	C3H/HeJ-Tyr^c-9J/J
001294	C3H/HeJ-Tyr^c-a/J
001002	C57BL/10SnJ-Tyr^c-11J/J
001006	CBA/J-Tyr^c-10J/J
000657	CE/J
007483	FVB.Cg-Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ
000494	J.Cg-Oca2⁺ Tyr⁺ Lyst^bg/J
002281	NFS.C58-Tyr⁺/J
004304	NOD.CBALs-Tyr⁺/LtJ
005115	NOD.FVB-Tg(INS-MT2A,Tyr)1Pne/PneJ
005114	NOD.FVB-Tg(Ins1-Cat,Tyr)25Pne/PneJ
001759	STOCK A Tyr^c Sha/J
000006	STOCK Hk Tyr^c/J
000206	STOCK a/a Tyr^c-h/J

Strain Name:

FVB.129P2-Pde6b+ Tyrc-ch/AntJ

Stock Number:

004828

Availability:

Repository- Live

General Terms and Conditions

Product Information

Strain Details

Tyrc-ch/Tyrc-ch

Gene & Allele Details

Control Information

Genotyping Protocols

Colony Maintenance

Related Strains

Additional Web Information

Animal Health Reports

Research Applications

References

Price and Supply Information

Price Details

*NO Shipping Destination selected!

Supply Details

General Terms and Conditions

The Jackson Laboratory's Genotype Promise

FVB.129P2-Pde6b⁺ Tyr^c-ch/AntJ

Tyr^c-ch/Tyr^c-ch