Strain Name: |
B6 x B6JCu.Cg-wl/J |
|---|---|
Stock Number: |
004835 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Former Name |
B6 x B6JCu-wl/J (Changed: 15-DEC-04
) |
|
B6.Cg-wl/J (Changed: 15-DEC-04
) | |
| Genes & Alleles | wl; |
Product Information
Strain Details
Type JAX® GEMM® Strain - Congenic Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Mutant Stock Type JAX® GEMM® Strain - Spontaneous Mutation Species laboratory mouse Generation F?+N1p (25-JAN-04) Strain Description
Homozygous wabbler-lethal mice are first recognizable at 12 days of age and usually die at about 4 weeks. They have an abnormal wobbly gait and a pronounced tremor when walking.
Gene & Allele Details
| Allele Symbol | wl | ||
|---|---|---|---|
| Allele Name | wabbler lethal | ||
| Strain of Origin | STOCK pi | ||
| General Note | Homozygotes are first recognizable at 12 days of age and usually die at about 4 weeks. They have an abnormal wobbly gait and a pronounced tremor when walking. Difficulty in walking increases in severity until the animal dies (J:13068). In an extensive study of behavioral development of this mutant, homozygotes were shown to be deficient in nearly all behaviors tested. From 20 days until death they were hypoglycemic (J:14851). Histological examination showed myelin degeneration widely distributed throughout the central nervous system, particularly in the vestibulocerebellar and spinocerebellar systems (J:15162). Electron microscopy showed widespread axonal (Wallerian) degeneration in the medulla with secondary myelin dissolution. Similar abnormalities were present to a lesser extent in the basal ganglia, spinal cord, and cerebellum (J:5028) and in the optic nerve (J:2856). Primary demyelination was found in the sciatic nerve (J:5028). Aromatic amino acid metabolism is abnormal in affected mice with depressed activity of phenyalanine hydroxylase and elevated activity of several other enzymes. This condition characterizes several other neurological mutants and is probably secondary to their neurological deficit (J:5108). | ||
Related Strains
Strains carrying wl allele
000147 WLHR/LeJ View Strains carrying wl (1 strain)
001767 C3H/HeSnJ-wlvmd/J 002457 CBA/J-wl3J/J
Additional Web Information
Congenic Nomenclature
Research Applications
This mouse can be used to support research in many areas including:wl related
Neurobiology Research
Ataxia (Movement) Defects
Myelination Defects
Tremor Defects
Vestibular and Hearing Defects
Sensorineural Research
Vestibular and Hearing Defects
References
Selected Reference(s)
Additional ReferencesCarroll EW; Curtis RL; Sullivan DA; Melvin JL. 1992. Wallerian degeneration in the optic nerve of the wabbler-lethal (wl/wl) mouse. Brain Res Bull 29(3-4):411-8. [PubMed: 1382814] [MGI Ref ID J:2856]
Price and Supply Information
| Strain Name: | B6 x B6JCu.Cg-wl/J |
| Stock Number: | 004835 |
Price Details
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery of Strains Needing Progeny Testing. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two untested males and two untested females (two pairs) will be recovered, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the overall recovery time to approximately 25 weeks. However, all pups recovered will be sent. Progeny testing is required to identify the genotype of mice of this strain, as a genotyping assay is not available. This type of testing involves breeding the recovered animals and assessing the phenotype of the offspring in order to identify animals carrying the mutation of interest. We can perform the progeny testing for you as a service or we can ship all recovered animals (at least two untested pairs) to you for progeny testing at your facility. If you perform the progeny testing, there is NO guarantee that a carrier will be identified. If we perform progeny testing as a service, additional breeding time will be required. In this case, when a male and female (one pair) are identified that carry the mutation, they and their offspring will be shipped. Delivery time for strains requiring progeny testing often exceeds 25 weeks and may take 12 months or more due to the difficulties in breeding some strains. The progeny testing cost is in addition to the recovery cost and is based on the number of boxes used and the time taken to produce the mice identified as carrying the mutation. Please note that identified pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Please contact Customer Service for more information on the cost of progeny testing for a strain: Tel: 1-800-422-6423 or 1-207-288-5845. Cryorecovery to establish a Dedicated Supply for greater quantities of mice |
| Licensing | See General Terms and Conditions below |
General Terms and Conditions
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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