Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names B6.Cg-T(12;16)1Cje    (Changed: 11-JAN-10 ) Type Chromosome Aberration; Translocation; Additional information on Mice with Chromosomal Aberrations. Type Congenic; Mutant Strain; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse

Related Strains

Strains carrying   Ts(16C-tel)1Cje allele

004861

B6EiC3Sn-Ts(16C-tel)1Cje/DnJ

View Strains carrying   Ts(16C-tel)1Cje     (1 strain)

Phenotype

Phenotype Information

Currently there is no phenotype information for this strain.

Genes & Alleles

Gene & Allele Information provided by MGI

Gene Symbol and Name		T(12;16)1Cje, reciprocal translocation, Chr 12 and 16, Epstein 1
Chromosome		12
Allele Symbol		Ts(16C-tel)1Cje
Allele Name		trisomy, (16C-tel), 1 Charles J Epstein
Allele Type		Spontaneous
Common Name(s)		Ts(1216)1Cje; Ts108Cje; Ts1Cje; partial trisomy 16;
Strain of Origin		C57BL/6J x (Rb(11.16)2H x Rb(16.17)32Lub)F1
ES Cell Line Name		CB1-4
ES Cell Line Strain		C57BL/6J x (Rb(11.16)2H x Rb(16.17)32Lub)F1
Gene Symbol and Name		Ts(16C-tel)1Cje, trisomy, (16C-tel), 1 Charles J Epstein
Chromosome		16
Gene Common Name(s)		Ts(1216)1Cje; Ts108Cje; Ts1Cje; partial trisomy 16; trisomy,Chr 12 translocation to Chr 16, Charles J Epstein;

Genotyping

Genotyping Information

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Sago H; Carlson EJ; Smith DJ; Kilbridge J; Rubin EM; Mobley WC; Epstein CJ; Huang TT. 1998. Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities. Proc Natl Acad Sci U S A 95(11):6256-61. [PubMed: 9600952]  [MGI Ref ID J:47907]

Sago H; Carlson EJ; Smith DJ; Rubin EM; Crnic LS; Huang TT; Epstein CJ. 2000. Genetic dissection of region associated with behavioral abnormalities in mouse models for Down syndrome. Pediatr Res 48(5):606-13. [PubMed: 11044479]  [MGI Ref ID J:86822]

Additional References

Huang TT; Yasunami M; Carlson EJ; Gillespie AM; Reaume AG; Hoffman EK ; Chan PH ; Scott RW ; Epstein CJ. 1997. Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch Biochem Biophys 344(2):424-32. [PubMed: 9264557]  [MGI Ref ID J:42265]

Ts(16C-tel)1Cje related

Alford KA; Slender A; Vanes L; Li Z; Fisher EM; Nizetic D; Orkin SH; Roberts I; Tybulewicz VL. 2010. Perturbed hematopoiesis in the Tc1 mouse model of Down syndrome. Blood 115(14):2928-37. [PubMed: 20154221]  [MGI Ref ID J:160790]

Alves-Sampaio A; Troca-Marin JA; Montesinos ML. 2010. NMDA-mediated regulation of DSCAM dendritic local translation is lost in a mouse model of Down's syndrome. J Neurosci 30(40):13537-48. [PubMed: 20926679]  [MGI Ref ID J:165095]

Amano K; Sago H; Uchikawa C; Suzuki T; Kotliarova SE; Nukina N; Epstein CJ; Yamakawa K. 2004. Dosage-dependent over-expression of genes in the trisomic region of Ts1Cje mouse model for Down syndrome. Hum Mol Genet 13(13):1333-40. [PubMed: 15138197]  [MGI Ref ID J:91249]

Belichenko PV; Kleschevnikov AM; Salehi A; Epstein CJ; Mobley WC. 2007. Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships. J Comp Neurol 504(4):329-45. [PubMed: 17663443]  [MGI Ref ID J:132525]

Canzonetta C; Mulligan C; Deutsch S; Ruf S; O'Doherty A; Lyle R; Borel C; Lin-Marq N; Delom F; Groet J; Schnappauf F; De Vita S; Averill S; Priestley JV; Martin JE; Shipley J; Denyer G; Epstein CJ; Fillat C; Estivill X; Tybulewicz VL; Fisher EM; Antonarakis SE; Nizetic D. 2008. DYRK1A-dosage imbalance perturbs NRSF/REST levels, deregulating pluripotency and embryonic stem cell fate in Down syndrome. Am J Hum Genet 83(3):388-400. [PubMed: 18771760]  [MGI Ref ID J:140118]

Carmichael CL; Majewski IJ; Alexander WS; Metcalf D; Hilton DJ; Hewitt CA; Scott HS. 2009. Hematopoietic defects in the Ts1Cje mouse model of Down syndrome. Blood 113(9):1929-37. [PubMed: 19109561]  [MGI Ref ID J:145995]

Colas D; Valletta JS; Takimoto-Kimura R; Nishino S; Fujiki N; Mobley WC; Mignot E. 2008. Sleep and EEG features in genetic models of Down syndrome. Neurobiol Dis 30(1):1-7. [PubMed: 18282758]  [MGI Ref ID J:136520]

Davisson M; Akeson E; Schmidt C; Harris B; Farley J; Handel MA. 2007. Impact of trisomy on fertility and meiosis in male mice. Hum Reprod 22(2):468-76. [PubMed: 17050550]  [MGI Ref ID J:117029]

Duchon A; Raveau M; Chevalier C; Nalesso V; Sharp AJ; Herault Y. 2011. Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling down syndrome. Mamm Genome 22(11-12):674-84. [PubMed: 21953411]  [MGI Ref ID J:178872]

Hewitt CA; Ling KH; Merson TD; Simpson KM; Ritchie ME; King SL; Pritchard MA; Smyth GK; Thomas T; Scott HS; Voss AK. 2010. Gene network disruptions and neurogenesis defects in the adult Ts1Cje mouse model of Down syndrome. PLoS One 5(7):e11561. [PubMed: 20661276]  [MGI Ref ID J:163093]

Huang TT; Yasunami M; Carlson EJ; Gillespie AM; Reaume AG; Hoffman EK ; Chan PH ; Scott RW ; Epstein CJ. 1997. Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch Biochem Biophys 344(2):424-32. [PubMed: 9264557]  [MGI Ref ID J:42265]

Ishihara K; Amano K; Takaki E; Ebrahim AS; Shimohata A; Shibazaki N; Inoue I; Takaki M; Ueda Y; Sago H; Epstein CJ; Yamakawa K. 2009. Increased lipid peroxidation in Down's syndrome mouse models. J Neurochem 110(6):1965-76. [PubMed: 19645748]  [MGI Ref ID J:152486]

Ishihara K; Amano K; Takaki E; Shimohata A; Sago H; Epstein CJ; Yamakawa K. 2010. Enlarged brain ventricles and impaired neurogenesis in the Ts1Cje and Ts2Cje mouse models of Down syndrome. Cereb Cortex 20(5):1131-43. [PubMed: 19710359]  [MGI Ref ID J:174165]

Klusmann JH; Godinho FJ; Heitmann K; Maroz A; Koch ML; Reinhardt D; Orkin SH; Li Z. 2010. Developmental stage-specific interplay of GATA1 and IGF signaling in fetal megakaryopoiesis and leukemogenesis. Genes Dev 24(15):1659-72. [PubMed: 20679399]  [MGI Ref ID J:163249]

Laffaire J; Rivals I; Dauphinot L; Pasteau F; Wehrle R; Larrat B; Vitalis T; Moldrich RX; Rossier J; Sinkus R; Herault Y; Dusart I; Potier MC. 2009. Gene expression signature of cerebellar hypoplasia in a mouse model of Down syndrome during postnatal development. BMC Genomics 10:138. [PubMed: 19331679]  [MGI Ref ID J:148509]

Levine S; Saltzman A; Levy E; Ginsberg SD. 2009. Systemic pathology in aged mouse models of Down's syndrome and Alzheimer's disease. Exp Mol Pathol 86(1):18-22. [PubMed: 19041304]  [MGI Ref ID J:174270]

Mouton-Liger F; Thomas S; Rattenbach R; Magnol L; Larigaldie V; Ledru A; Herault Y; Verney C; Creau N. 2011. PCP4 (PEP19) overexpression induces premature neuronal differentiation associated with Ca(2+) /Calmodulin-Dependent kinase II-delta activation in mouse models of down syndrome. J Comp Neurol 519(14):2779-802. [PubMed: 21491429]  [MGI Ref ID J:174150]

Olson LE; Roper RJ; Baxter LL; Carlson EJ; Epstein CJ; Reeves RH. 2004. Down syndrome mouse models Ts65Dn, Ts1Cje, and Ms1Cje/Ts65Dn exhibit variable severity of cerebellar phenotypes. Dev Dyn 230(3):581-9. [PubMed: 15188443]  [MGI Ref ID J:91221]

Potier MC; Rivals I; Mercier G; Ettwiller L; Moldrich RX; Laffaire J; Personnaz L; Rossier J; Dauphinot L. 2006. Transcriptional disruptions in Down syndrome: a case study in the Ts1Cje mouse cerebellum during post-natal development. J Neurochem 97 Suppl 1:104-9. [PubMed: 16635258]  [MGI Ref ID J:144411]

Rachidi M; Lopes C. 2007. Mental retardation in Down syndrome: from gene dosage imbalance to molecular and cellular mechanisms. Neurosci Res 59(4):349-69. [PubMed: 17897742]  [MGI Ref ID J:128743]

Richtsmeier JT; Zumwalt A; Carlson EJ; Epstein CJ; Reeves RH. 2002. Craniofacial phenotypes in segmentally trisomic mouse models for Down syndrome. Am J Med Genet 107(4):317-24. [PubMed: 11840489]  [MGI Ref ID J:73800]

Salehi A; Delcroix JD; Belichenko PV; Zhan K; Wu C; Valletta JS; Takimoto-Kimura R; Kleschevnikov AM; Sambamurti K; Chung PP; Xia W; Villar A; Campbell WA; Kulnane LS; Nixon RA; Lamb BT; Epstein CJ; Stokin GB; Goldstein LS; Mobley WC. 2006. Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron 51(1):29-42. [PubMed: 16815330]  [MGI Ref ID J:122937]

Salehi A; Faizi M; Colas D; Valletta J; Laguna J; Takimoto-Kimura R; Kleschevnikov A; Wagner SL; Aisen P; Shamloo M; Mobley WC. 2009. Restoration of norepinephrine-modulated contextual memory in a mouse model of Down syndrome. Sci Transl Med 1(7):7ra17. [PubMed: 20368182]  [MGI Ref ID J:167886]

Shukkur EA; Shimohata A; Akagi T; Yu W; Yamaguchi M; Murayama M; Chui D; Takeuchi T; Amano K; Subramhanya KH; Hashikawa T; Sago H; Epstein CJ; Takashima A; Yamakawa K. 2006. Mitochondrial dysfunction and tau hyperphosphorylation in Ts1Cje, a mouse model for Down syndrome. Hum Mol Genet 15(18):2752-62. [PubMed: 16891409]  [MGI Ref ID J:114926]

Siarey RJ; Villar AJ; Epstein CJ; Galdzicki Z. 2005. Abnormal synaptic plasticity in the Ts1Cje segmental trisomy 16 mouse model of Down syndrome. Neuropharmacology 49(1):122-8. [PubMed: 15992587]  [MGI Ref ID J:106375]

Siddiqui A; Lacroix T; Stasko MR; Scott-McKean JJ; Costa AC; Gardiner KJ. 2008. Molecular responses of the Ts65Dn and Ts1Cje mouse models of Down syndrome to MK-801. Genes Brain Behav 7(7):810-20. [PubMed: 19125866]  [MGI Ref ID J:151137]

Vialard F; Toyama K; Vernoux S; Carlson EJ; Epstein CJ; Sinet PM; Rahmani Z. 2000. Overexpression of mSim2 gene in the zona limitans of the diencephalon of segmental trisomy 16 Ts1Cje fetuses, a mouse model for trisomy 21: a novel whole-mount based RNA hybridization study. Brain Res Dev Brain Res 121(1):73-8. [PubMed: 10837894]  [MGI Ref ID J:62599]

Villar AJ; Belichenko PV; Gillespie AM; Kozy HM; Mobley WC; Epstein CJ. 2005. Identification and characterization of a new Down syndrome model, Ts[Rb(12.1716)]2Cje, resulting from a spontaneous Robertsonian fusion between T(171)65Dn and mouse chromosome 12. Mamm Genome 16(2):79-90. [PubMed: 15859352]  [MGI Ref ID J:96650]

Wiseman FK; Alford KA; Tybulewicz VL; Fisher EM. 2009. Down syndrome--recent progress and future prospects. Hum Mol Genet 18(R1):R75-83. [PubMed: 19297404]  [MGI Ref ID J:156661]

Health & husbandry

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Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

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