Strain Name:

B6;129-Gt(ROSA)26Sortm1(cre/ERT)Nat/J

Stock Number:

004847

Order this mouse

Availability:

Repository- Live

Other products are available, see Purchasing Information for Cryopreserved Embryos

Use Restrictions Apply, see Terms of Use
Common Names: R26CreER;    
These R26CreER mutant mice have a tamoxifen-inducible Cre-mediated recombination system driven by the endogenous mouse Gt(ROSA)26Sor promoter. When crossed with a strain containing a loxP site-flanked sequence of interest, this mutant is useful for generating tamoxifen-induced, Cre-mediated targeted deletions.

Description

Strain Information

Former Names B6;129-Gt(ROSA)26Sortm1(cre/Esr1)Nat/J    (Changed: 30-MAR-10 )
Type Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Specieslaboratory mouse
GenerationF?+F11N1F13 (24-JAN-14)
Generation Definitions
 
Donating Investigator Jeremy Nathans,   Johns Hopkins University

Description
These R26CreER mutant mice have a tamoxifen-inducible Cre-mediated recombination system driven by the endogenous mouse Gt(ROSA)26Sor promoter. The mutant allele consists of a fusion product involving Cre recombinase and an altered version of the mouse estrogen receptor ligand binding domain. The mutant ligand binding domain does not bind natural ligand at physiological concentrations but will bind the synthetic ligand, 4-hydroxytamoxifen. Restricted to the cytoplasm, the CRE/ESR1 protein can only gain access to the nuclear compartment to mediate recombination after exposure to tamoxifen. Tamoxifen administration will also induce Cre recombination in the developing embryos of treated mothers. When crossed with a strain containing a loxP site-flanked sequence of interest, this mutant is useful for generating tamoxifen-induced, Cre-mediated targeted deletions. Homozygous mutant mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities.

Development
A targeting vector containing a PGK-neo cassette and Cre recombinase/estrogen receptor ligand-binding domain fusion protein sequence was used to insert the fusion protein into a site located within intron 1 of the GT(ROSA)26Sor locus. The construct was introduced into 129X1/SvJ x 129S1/Sv-derived R1-derived embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6 blastocysts. Correctly targeted ES cells were injected into C57BL/6J blastocysts to obtain chimeric animals.

Control Information

  Control
   101045 B6129SF2/J (approximate)
 
  Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of Gt(ROSA)26Sor
002292   129-Gt(ROSA)26Sor/J
006053   129-Gt(ROSA)26Sortm1(CAG-EGFP)Luo/J
006067   129-Gt(ROSA)26Sortm2(CAG-Dsred2/EGFP)Luo/J
006041   129-Gt(ROSA)26Sortm3(CAG-EGFP/Dsred2)Luo/J
013205   129S-Gt(ROSA)26Sortm1(NOTCH3)Sat/Mmjax
003310   129S-Gt(ROSA)26Sortm1Sor/J
013207   129S-Gt(ROSA)26Sortm2(NOTCH3*C455R)Sat/Mmjax
009043   129S-Gt(ROSA)26Sortm3(CAG-luc)Tyj/J
007844   129S4/SvJae-Gt(ROSA)26Sortm2(FLP*)Sor/J
003946   129S4/SvJaeSor-Gt(ROSA)26Sortm1(FLP1)Dym/J
007689   129S4/SvJaeSor-Gt(ROSA)26Sortm4(attB/attP)Sor/J
017626   B6(Cg)-Gt(ROSA)26Sortm1(CAG-GFP/Eif2c2)Zjh/J
026283   B6(Cg)-Gt(ROSA)26Sortm1(CAG-Trp53*,-EGFP)Medz/J
010633   B6(Cg)-Gt(ROSA)26Sortm1(CAG-taulacZ)Bene/J
024540   B6(Cg)-Gt(ROSA)26Sortm1(Sstr3/GFP)Bky/J
008242   B6(Cg)-Gt(ROSA)26Sortm4(Ikbkb)Rsky/J
007676   B6.129(Cg)-Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/J
006071   B6.129-Gt(ROSA)26Sortm1(CAG-EGFP)Luo/J
007708   B6.129-Gt(ROSA)26Sortm1(HD*103Q)Xwy/J
024512   B6.129-Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key/J
008463   B6.129-Gt(ROSA)26Sortm1(cre/ERT2)Tyj/J
008606   B6.129-Gt(ROSA)26Sortm1Joe/J
006080   B6.129-Gt(ROSA)26Sortm2(CAG-Dsred2/EGFP)Luo/J
006075   B6.129-Gt(ROSA)26Sortm3(CAG-EGFP/Dsred2)Luo/J
011008   B6.129P2(Cg)-Gt(ROSA)26Sortm1(tTA)Roos/J
017492   B6.129P2-Gt(ROSA)26Sortm1(CAG-Brainbow2.1)Cle/J
009669   B6.129P2-Gt(ROSA)26Sortm1(DTA)Lky/J
008513   B6.129P2-Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde/J
013586   B6.129P2-Gt(ROSA)26Sortm1Nik/J
013587   B6.129P2-Gt(ROSA)26Sortm3Nik/J
022367   B6.129S4-Gt(ROSA)26Sortm1(CAG-EGFP/Rpl10a,-birA)Wtp/J
009086   B6.129S4-Gt(ROSA)26Sortm1(FLP1)Dym/RainJ
003474   B6.129S4-Gt(ROSA)26Sortm1Sor/J
012930   B6.129S4-Gt(ROSA)26Sortm2(FLP*)Sor/J
009044   B6.129S4-Gt(ROSA)26Sortm3(CAG-luc)Tyj/J
007743   B6.129S4-Gt(ROSA)26Sortm3(phiC31*)Sor/J
009673   B6.129S6(C)-Gt(ROSA)26Sortm3(HIF1A*)Kael/J
022626   B6.129S6(SJL)-Gt(ROSA)26Sortm2.1(mix1b-mCherry)Mgn/Mmjax
002192   B6.129S7-Gt(ROSA)26Sor/J
006148   B6.129X1-Gt(ROSA)26Sortm1(EYFP)Cos/J
026294   B6.Cg(129S)-Gt(ROSA)26Sortm2.2Ksvo/J
021071   B6.Cg-Gt(ROSA)26Sortm1(CAG-PA-GFP)Rmpl/J
014588   B6.Cg-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm6(tetO-MSI2)Jae/J
017983   B6.Cg-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm9(tetO-Dnmt3b_i1)Jae/J
014602   B6.Cg-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm1(tetO-mCherry)Eggn/J
023749   B6.Cg-Gt(ROSA)26Sortm1(rtTA*M2)Jae Tg(tetO-Pou5f1,-Sox2,-Klf4,-Myc)1Srn/J
006965   B6.Cg-Gt(ROSA)26Sortm1(rtTA*M2)Jae/J
005670   B6.Cg-Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/J
026930   B6.Cg-Gt(ROSA)26Sortm1.1(CAG-tdTomato,-EGFP)Pjen/J
026931   B6.Cg-Gt(ROSA)26Sortm1.2(CAG-tdTomato,-EGFP)Pjen/J
026932   B6.Cg-Gt(ROSA)26Sortm1.3(CAG-tdTomato,-EGFP)Pjen/J
007914   B6.Cg-Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/J
007920   B6.Cg-Gt(ROSA)26Sortm2(CAG-EYFP)Hze/J
012567   B6.Cg-Gt(ROSA)26Sortm27.1(CAG-COP4*H134R/tdTomato)Hze/J
007903   B6.Cg-Gt(ROSA)26Sortm3(CAG-EYFP)Hze/J
024109   B6.Cg-Gt(ROSA)26Sortm32(CAG-COP4*H134R/EYFP)Hze/J
014648   B6.Cg-Gt(ROSA)26Sortm37(H1/tetO-RNAi:Taz)Arte/ZkhuJ
021188   B6.Cg-Gt(ROSA)26Sortm40.1(CAG-aop3/EGFP)Hze/J
007906   B6.Cg-Gt(ROSA)26Sortm6(CAG-ZsGreen1)Hze/J
025106   B6.Cg-Gt(ROSA)26Sortm75.1(CAG-tdTomato*)Hze/J
025109   B6.Cg-Gt(ROSA)26Sortm80.1(CAG-COP4*L132C/EYFP)Hze/J
007909   B6.Cg-Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/J
007897   B6.Cg-Tg(Gt(ROSA)26Sor-EGFP)I1Able/J
024179   B6;129-Gt(ROSA)26Sortm1(Actb-T,-GFP)Dalco/J
017455   B6;129-Gt(ROSA)26Sortm1(CAG-COP4*E123T*H134R,-tdTomato)Gfng/J
024857   B6;129-Gt(ROSA)26Sortm1(CAG-cas9*,-EGFP)Fezh/J
010527   B6;129-Gt(ROSA)26Sortm1(DTA)Mrc/J
016262   B6;129-Gt(ROSA)26Sortm1(Foxo1/GFP)Jke/J
017962   B6;129-Gt(ROSA)26Sortm1(RAC1*)Jkis/J
008883   B6;129-Gt(ROSA)26Sortm1(SNCA*A53T)Djmo/TmdJ
021025   B6;129-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm1(tetO-cre)Haho/J
006911   B6;129-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm2(tetO-Pou5f1)Jae/J
008516   B6;129-Gt(ROSA)26Sortm1Joe/J
003504   B6;129-Gt(ROSA)26Sortm1Sho/J
021847   B6;129-Gt(ROSA)26Sortm1Ytchn/J
008889   B6;129-Gt(ROSA)26Sortm2(SNCA*119)Djmo/TmdJ
009253   B6;129-Gt(ROSA)26Sortm2Nat/J
004077   B6;129-Gt(ROSA)26Sortm2Sho/J
008886   B6;129-Gt(ROSA)26Sortm3(SNCA*E46K)Djmo/TmdJ
010557   B6;129-Gt(ROSA)26Sortm3(rtTA,tetO-cre/ERT)Nat/J
021429   B6;129-Gt(ROSA)26Sortm4(CAG-GFP*)Nat/J
021039   B6;129-Gt(ROSA)26Sortm5(CAG-Sun1/sfGFP)Nat/J
023843   B6;129-Gt(ROSA)26Sortm6(Fzd6)Nat/J
010523   B6;129P2-Gt(ROSA)26Sortm1(CAG-ALPP)Fawa/J
024708   B6;129P2-Gt(ROSA)26Sortm1(CAG-RABVgp4,-TVA)Arenk/J
002073   B6;129S-Gt(ROSA)26Sor/J
018385   B6;129S-Gt(ROSA)26Sortm1(CAG-COX8A/Dendra2)Dcc/J
022516   B6;129S-Gt(ROSA)26Sortm1(Cdkn1c)Jfpa/J
013206   B6;129S-Gt(ROSA)26Sortm1(NOTCH3*R1031C)Sat/Mmjax
018397   B6;129S-Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/J
023139   B6;129S-Gt(ROSA)26Sortm1.1Ksvo/J
024846   B6;129S-Gt(ROSA)26Sortm2.1Ksvo/J
012569   B6;129S-Gt(ROSA)26Sortm32(CAG-COP4*H134R/EYFP)Hze/J
012570   B6;129S-Gt(ROSA)26Sortm34.1(CAG-Syp/tdTomato)Hze/J
012735   B6;129S-Gt(ROSA)26Sortm35.1(CAG-aop3/GFP)Hze/J
014538   B6;129S-Gt(ROSA)26Sortm38(CAG-GCaMP3)Hze/J
014539   B6;129S-Gt(ROSA)26Sortm39(CAG-hop/EYFP)Hze/J
021875   B6;129S-Gt(ROSA)26Sortm65.1(CAG-tdTomato)Hze/J
021876   B6;129S-Gt(ROSA)26Sortm66.1(CAG-tdTomato)Hze/J
024105   B6;129S-Gt(ROSA)26Sortm95.1(CAG-GCaMP6f)Hze/J
016836   B6;129S4-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm7(tetO-HIST1H2BJ/GFP)Jae/J
003309   B6;129S4-Gt(ROSA)26Sortm1Sor/J
004598   B6;129S4-Gt(ROSA)26Sortm2Dym/J
007670   B6;129S4-Gt(ROSA)26Sortm3(phiC31*)Sor/J
024750   B6;129S4-Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc/J
023035   B6;129S6-Gt(ROSA)26Sortm1(CAG-tdTomato*,-EGFP*)Ees/J
016999   B6;129S6-Gt(ROSA)26Sortm1(rtTA2S*M2)Whsu/J
007908   B6;129S6-Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/J
007905   B6;129S6-Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/J
024106   B6;129S6-Gt(ROSA)26Sortm96(CAG-GCaMP6s)Hze/J
026175   B6J.129(B6N)-Gt(ROSA)26Sortm1(CAG-cas9*,-EGFP)Fezh/J
026179   B6J.129(Cg)-Gt(ROSA)26Sortm1.1(CAG-cas9,-EGFP)Fezh/J
026219   B6N.129-Gt(ROSA)26Sortm1(CAG-CHRM4*,-mCitrine)Ute/J
019101   B6N.129S4(B6)-Gt(ROSA)26Sortm1Sor/CjDswJ
016226   B6N.129S4-Gt(ROSA)26Sortm1(FLP1)Dym/J
019013   B6N.129S6(Cg)-Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
019016   B6N.129S6(Cg)-Gt(ROSA)26Sortm3(CAG-FLPo/ERT2)Alj/J
023537   B6N.129S6-Gt(ROSA)26Sortm1(CAG-tdTomato*,-EGFP*)Ees/J
026220   B6N;129-Gt(ROSA)26Sortm2(CAG-CHRM3*,-mCitrine)Ute/J
026261   B6N;129-Gt(ROSA)26Sortm3(CAG-Chrm3*,-mCitrine)Ute/J
025701   B6N;129S1-Gt(ROSA)26Sortm1(Grem1)Svok/J
019120   BALB/c-Gt(ROSA)26Sortm10(Lmp1)Rsky/J
009670   C.129P2(B6)-Gt(ROSA)26Sortm1(DTA)Lky/J
008603   C.129P2(B6)-Gt(ROSA)26Sortm1(tTA)Roos/J
002955   C.129S7-Gt(ROSA)26Sor/J
025322   C57BL/6-Gt(ROSA)26Sortm1(CAG-MFN2*T105M)Dple/J
007900   C57BL/6-Gt(ROSA)26Sortm1(HBEGF)Awai/J
008517   C57BL/6-Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/J
012637   C57BL/6-Gt(ROSA)26Sortm5(Map3k14)Rsky/J
012638   C57BL/6-Gt(ROSA)26Sortm6(Map3k14*)Rsky/J
012343   C57BL/6-Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky/J
012352   C57BL/6-Gt(ROSA)26Sortm8(Map2k1*,EGFP)Rsky/J
012361   C57BL/6-Gt(ROSA)26Sortm9(Rac1*,EGFP)Rsky/J
020458   C57BL/6N-Gt(ROSA)26Sortm13(CAG-MYC,-CD2*)Rsky/J
005420   C;129S7 Gt(ROSA)26Sor-Bmp5cfe-se7J/GrsrJ
008040   CBy.B6-Gt(ROSA)26Sortm1(HBEGF)Awai/J
007898   CBy.Cg-Tg(Gt(ROSA)26Sor-EGFP)I1Able/J
026862   D2.129(Cg)-Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/SjJ
026863   D2.129S4(B6)-Gt(ROSA)26Sortm1Sor/SjJ
009427   FVB.129S4(B6)-Gt(ROSA)26Sortm1Sor/J
005125   FVB.129S6(B6)-Gt(ROSA)26Sortm1(Luc)Kael/J
016977   FVB.129S6-Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/J
006206   FVB.129S6-Gt(ROSA)26Sortm2(HIF1A/luc)Kael/J
012429   FVB.Cg-Gt(ROSA)26Sortm1(CAG-lacZ,-EGFP)Glh/J
010920   FVB;129P2-Gt(ROSA)26Sortm1.1(birA)Mejr/J
016603   NOD.B6-Gt(ROSA)26Sortm1(HBEGF)Awai/DvsJ
013731   STOCK Gt(ROSA)26Sortm1(CAG-Brainbow2.1)Cle/J
010675   STOCK Gt(ROSA)26Sortm1(CAG-EGFP)Fsh/Mmjax
006331   STOCK Gt(ROSA)26Sortm1(DTA)Jpmb/J
022793   STOCK Gt(ROSA)26Sortm1(LRRK2*R1441C)Djmo/J
023451   STOCK Gt(ROSA)26Sortm1(Luc)Kael Tg(UBC-CCR5,-CD4)19Mnz/J
008159   STOCK Gt(ROSA)26Sortm1(Notch1)Dam/J
005130   STOCK Gt(ROSA)26Sortm1(Smo/EYFP)Amc/J
018121   STOCK Gt(ROSA)26Sortm1(birA)Mejr Gata4tm3.1Wtp/J
011004   STOCK Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm3(tetO-Pou5f1,-Sox2,-Klf4,-Myc)Jae/J
011011   STOCK Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm4(tetO-Pou5f1,-Sox2,-Klf4,-Myc)Jae/J
011013   STOCK Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm5(tetO-Pou5f1,-Klf4,-Myc)Jae/J
005572   STOCK Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/J
008600   STOCK Gt(ROSA)26Sortm1(tTA)Roos/J
010701   STOCK Gt(ROSA)26Sortm1.1(CAG-EGFP)Fsh/Mmjax
022386   STOCK Gt(ROSA)26Sortm1.1(CAG-EGFP/Rpl10a,-birA)Wtp/J
024858   STOCK Gt(ROSA)26Sortm1.1(CAG-cas9,-EGFP)Fezh/J
025983   STOCK Gt(ROSA)26Sortm1.1(birA)Mejr Mef2ctm1.1Wtp/Mmjax
025977   STOCK Gt(ROSA)26Sortm1.1(birA)Mejr Zfpm2tm1.1Wtp /Mmjax
017596   STOCK Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb Tg(tetO-SMN2,-luc)#aAhmb/J
017597   STOCK Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb Tg(tetO-SMN2,-luc)#bAhmb/J
025671   STOCK Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy Tg(tetO-Fgf10)1Jaw/SpdlJ
024746   STOCK Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy Hprttm1(tetO-Dkk1)Spdl Tg(TCF/Lef1-lacZ)34Efu/J
010812   STOCK Gt(ROSA)26Sortm1.2(CAG-EGFP)Fsh/Mmjax
017922   STOCK Gt(ROSA)26Sortm10(ACTB-tdTomato)Luo/J
023898   STOCK Gt(ROSA)26Sortm11.1(Setd5-GFP)Mgn/Mmjax
026570   STOCK Gt(ROSA)26Sortm1Embph/J
018903   STOCK Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
018906   STOCK Gt(ROSA)26Sortm3(CAG-FLPo/ERT2)Alj/J
013124   STOCK Gt(ROSA)26Sortm3(Gli3)Amc/J
007576   STOCK Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/J
009674   STOCK Gt(ROSA)26Sortm4(HIF2A*)Kael/J
024107   STOCK Gt(ROSA)26Sortm5(ACTB-tTA)Luo Igs7tm93.1(tetO-GCaMP6f)Hze/HzeJ
012266   STOCK Gt(ROSA)26Sortm5(ACTB-tTA)Luo/J
017912   STOCK Gt(ROSA)26Sortm6(ACTB-EGFP*,-tdTomato)Luo/J
013123   STOCK Gt(ROSA)26Sortm6(Gli1)Amc/J
017921   STOCK Gt(ROSA)26Sortm7(ACTB-EGFP*)Luo/J
017909   STOCK Gt(ROSA)26Sortm8(ACTB-EGFP*,-tTA2)Luo/J
025982   STOCK Rbpjtm1.1Wtp Gt(ROSA)26Sortm1.1birA)Mejr/Mmjax
007577   STOCK Tg(Gt(ROSA)26Sor-BCHE*G117H)837Loc/J
007896   STOCK Tg(Gt(ROSA)26Sor-EGFP)I1Able/J
View Strains carrying other alleles of Gt(ROSA)26Sor     (186 strains)

View Strains carrying other alleles of cre/ER     (12 strains)

Additional Web Information

Information about the Rosa26 locus on the Soriano lab web page

Introduction to Cre-lox technology

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1(cre/ERT)Nat

        B6.129-Gt(ROSA)26Sortm1(cre/Esr1)Nat
  • normal phenotype
  • no abnormal phenotype detected   (MGI Ref ID J:84747)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Research Tools
Cre-lox System
      Cre Recombinase Expression
      Cre Recombinase Expression: Inducible
Genetics Research
      Mutagenesis and Transgenesis
      Mutagenesis and Transgenesis: Cre-lox System

Gt(ROSA)26Sortm1(cre/ERT)Nat related

Developmental Biology Research
Internal/Organ Defects
      ovary; uterus

Internal/Organ Research
Other Organ Defects

Reproductive Biology Research
Developmental Defects Affecting Gonads
      germ cell deficient
Fertility Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Gt(ROSA)26Sortm1(cre/ERT)Nat
Allele Name targeted mutation 1, Jeremy Nathans
Allele Type Targeted (Inducible, cre- or Flp-expressing)
Common Name(s) CreERT1; Gt(ROSA)26Sortm1(cre/Esr1)Nat; R26CreER; R26ERCre; R26RNatCre;
Mutation Made By Tudor Badea,   Johns Hopkins University
Strain of Origin(129X1/SvJ x 129S1/Sv)F1-Kitl<+>
ES Cell Line NameR1
ES Cell Line Strain(129X1/SvJ x 129S1/Sv)F1-Kitl<+>
Site of Expressiontamoxifen-inducible cre; when crossed with a strain containing a loxP site-flanked sequence of interest, this mutant is useful for generating tamoxifen-induced, Cre-mediated targeted deletions
Expressed Gene cre/ER, cre inducible estrogen receptor, bacteriophage P1/Human
Gene Symbol and Name Gt(ROSA)26Sor, gene trap ROSA 26, Philippe Soriano
Chromosome 6
Gene Common Name(s) AV258896; Gtrgeo26; Gtrosa26; R26; ROSA26; SETD5-AS1; beta geo; expressed sequence AV258896; gene trap ROSA 26; gene trap ROSA b-geo 26;
Driver Note Gt(ROSA)26Sor
Inducible Note induced by tamoxifen
Molecular Note A cDNA fragment encoding a fusion protein comprised of cre recombinase and the ligand binding domain of Esr1 was inserted at the endogenous locus via homologous recombination. The initiator methionine was placed in an optimal translational context, allowing for near ubiquitous expression via the endogenous promoter. Activation of cre recombinase activity is dependent on the administration of 4-HO-tamoxifen. [MGI Ref ID J:84747]
 

Genotyping

Genotyping Information

Genotyping Protocols

Gt(ROSA)26Sortm1(cre/ERT)Natalternate2, Standard PCR
Gt(ROSA)26Sortm1(cre/Esr1)Nat, Separated PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Badea TC; Wang Y; Nathans J. 2003. A noninvasive genetic/pharmacologic strategy for visualizing cell morphology and clonal relationships in the mouse. J Neurosci 23(6):2314-22. [PubMed: 12657690]  [MGI Ref ID J:84747]

Additional References

Gt(ROSA)26Sortm1(cre/ERT)Nat related

Badea TC; Cahill H; Ecker J; Hattar S; Nathans J. 2009. Distinct roles of transcription factors brn3a and brn3b in controlling the development, morphology, and function of retinal ganglion cells. Neuron 61(6):852-64. [PubMed: 19323995]  [MGI Ref ID J:147350]

Badea TC; Hua ZL; Smallwood PM; Williams J; Rotolo T; Ye X; Nathans J. 2009. New mouse lines for the analysis of neuronal morphology using CreER(T)/loxP-directed sparse labeling. PLoS One 4(11):e7859. [PubMed: 19924248]  [MGI Ref ID J:155417]

Badea TC; Williams J; Smallwood P; Shi M; Motajo O; Nathans J. 2012. Combinatorial expression of brn3 transcription factors in somatosensory neurons: genetic and morphologic analysis. J Neurosci 32(3):995-1007. [PubMed: 22262898]  [MGI Ref ID J:179888]

Bondar T; Medzhitov R. 2010. p53-mediated hematopoietic stem and progenitor cell competition. Cell Stem Cell 6(4):309-22. [PubMed: 20362536]  [MGI Ref ID J:158953]

Campolo F; Gori M; Favaro R; Nicolis S; Pellegrini M; Botti F; Rossi P; Jannini EA; Dolci S. 2013. Essential role of sox2 for the establishment and maintenance of the germ cell line. Stem Cells :. [PubMed: 23553930]  [MGI Ref ID J:196968]

Cellurale C; Girnius N; Jiang F; Cavanagh-Kyros J; Lu S; Garlick DS; Mercurio AM; Davis RJ. 2012. Role of JNK in mammary gland development and breast cancer. Cancer Res 72(2):472-81. [PubMed: 22127926]  [MGI Ref ID J:181146]

Cellurale C; Sabio G; Kennedy NJ; Das M; Barlow M; Sandy P; Jacks T; Davis RJ. 2011. Requirement of c-Jun NH2-Terminal Kinase for Ras-Initiated Tumor Formation. Mol Cell Biol 31(7):1565-76. [PubMed: 21282468]  [MGI Ref ID J:170101]

Chen J; Chen J; Zhu Y; Liang C; Zhao HB. 2014. Deafness induced by Connexin 26 (GJB2) deficiency is not determined by endocochlear potential (EP) reduction but is associated with cochlear developmental disorders. Biochem Biophys Res Commun 448(1):28-32. [PubMed: 24732355]  [MGI Ref ID J:219459]

Chiang PM; Ling J; Jeong YH; Price DL; Aja SM; Wong PC. 2010. Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism. Proc Natl Acad Sci U S A 107(37):16320-4. [PubMed: 20660762]  [MGI Ref ID J:164406]

Chong MM; Rasmussen JP; Rundensky AY; Littman DR. 2008. The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease. J Exp Med 205(9):2005-17. [PubMed: 18725527]  [MGI Ref ID J:138683]

Chong MM; Zhang G; Cheloufi S; Neubert TA; Hannon GJ; Littman DR. 2010. Canonical and alternate functions of the microRNA biogenesis machinery. Genes Dev 24(17):1951-60. [PubMed: 20713509]  [MGI Ref ID J:163823]

Collins C; Wang J; Miao H; Bronstein J; Nawer H; Xu T; Figueroa M; Muntean AG; Hess JL. 2014. C/EBPalpha is an essential collaborator in Hoxa9/Meis1-mediated leukemogenesis. Proc Natl Acad Sci U S A 111(27):9899-904. [PubMed: 24958854]  [MGI Ref ID J:212177]

Cornacchia D; Dileep V; Quivy JP; Foti R; Tili F; Santarella-Mellwig R; Antony C; Almouzni G; Gilbert DM; Buonomo SB. 2012. Mouse Rif1 is a key regulator of the replication-timing programme in mammalian cells. EMBO J 31(18):3678-90. [PubMed: 22850673]  [MGI Ref ID J:188030]

Cowley DO; Rivera-Perez JA; Schliekelman M; He YJ; Oliver TG; Lu L; O'Quinn R; Salmon ED; Magnuson T; Van Dyke T. 2009. Aurora-A kinase is essential for bipolar spindle formation and early development. Mol Cell Biol 29(4):1059-71. [PubMed: 19075002]  [MGI Ref ID J:145744]

Das M; Jiang F; Sluss HK; Zhang C; Shokat KM; Flavell RA; Davis RJ. 2007. Suppression of p53-dependent senescence by the JNK signal transduction pathway. Proc Natl Acad Sci U S A 104(40):15759-64. [PubMed: 17893331]  [MGI Ref ID J:131766]

Doan LT; Javier AL; Furr NM; Nguyen KL; Cho KW; Monuki ES. 2012. A Bmp reporter with ultrasensitive characteristics reveals that high Bmp signaling is not required for cortical hem fate. PLoS One 7(9):e44009. [PubMed: 22984456]  [MGI Ref ID J:192898]

Dubois CL; Shih HP; Seymour PA; Patel NA; Behrmann JM; Ngo V; Sander M. 2011. Sox9-haploinsufficiency causes glucose intolerance in mice. PLoS One 6(8):e23131. [PubMed: 21829703]  [MGI Ref ID J:176523]

Ferguson SM; Raimondi A; Paradise S; Shen H; Mesaki K; Ferguson A; Destaing O; Ko G; Takasaki J; Cremona O; O' Toole E; De Camilli P. 2009. Coordinated actions of actin and BAR proteins upstream of dynamin at endocytic clathrin-coated pits. Dev Cell 17(6):811-22. [PubMed: 20059951]  [MGI Ref ID J:161127]

Flora A; Klisch TJ; Schuster G; Zoghbi HY. 2009. Deletion of Atoh1 disrupts Sonic Hedgehog signaling in the developing cerebellum and prevents medulloblastoma. Science 326(5958):1424-7. [PubMed: 19965762]  [MGI Ref ID J:155047]

Fu X; Zhao JX; Zhu MJ; Foretz M; Viollet B; Dodson MV; Du M. 2013. AMP-activated protein kinase alpha1 but not alpha2 catalytic subunit potentiates myogenin expression and myogenesis. Mol Cell Biol 33(22):4517-25. [PubMed: 24043309]  [MGI Ref ID J:206092]

Furumoto Y; Charles N; Olivera A; Leung WH; Dillahunt S; Sargent JL; Tinsley K; Odom S; Scott E; Wilson TM; Ghoreschi K; Kneilling M; Chen M; Lee DM; Bolland S; Rivera J. 2011. PTEN deficiency in mast cells causes a mastocytosis-like proliferative disease that heightens allergic responses and vascular permeability. Blood 118(20):5466-75. [PubMed: 21926349]  [MGI Ref ID J:178784]

Gantier MP; McCoy CE; Rusinova I; Saulep D; Wang D; Xu D; Irving AT; Behlke MA; Hertzog PJ; Mackay F; Williams BR. 2011. Analysis of microRNA turnover in mammalian cells following Dicer1 ablation. Nucleic Acids Res 39(13):5692-703. [PubMed: 21447562]  [MGI Ref ID J:174036]

Gantier MP; Stunden HJ; McCoy CE; Behlke MA; Wang D; Kaparakis-Liaskos M; Sarvestani ST; Yang YH; Xu D; Corr SC; Morand EF; Williams BR. 2012. A miR-19 regulon that controls NF-kappaB signaling. Nucleic Acids Res 40(16):8048-58. [PubMed: 22684508]  [MGI Ref ID J:198890]

Ghosh S; Lau H; Simons BW; Powell JD; Meyers DJ; De Marzo AM; Berman DM; Lotan TL. 2011. PI3K/mTOR signaling regulates prostatic branching morphogenesis. Dev Biol 360(2):329-42. [PubMed: 22015718]  [MGI Ref ID J:178714]

Haldar M; Hedberg ML; Hockin MF; Capecchi MR. 2009. A CreER-based random induction strategy for modeling translocation-associated sarcomas in mice. Cancer Res 69(8):3657-64. [PubMed: 19351831]  [MGI Ref ID J:147728]

Harms MJ; Ishibashi J; Wang W; Lim HW; Goyama S; Sato T; Kurokawa M; Won KJ; Seale P. 2014. Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice. Cell Metab 19(4):593-604. [PubMed: 24703692]  [MGI Ref ID J:213153]

Ikeda Y; Morioka S; Matsumoto K; Ninomiya-Tsuji J. 2014. TAK1 binding protein 2 is essential for liver protection from stressors. PLoS One 9(2):e88037. [PubMed: 24498425]  [MGI Ref ID J:212972]

Jones C; Roper VC; Foucher I; Qian D; Banizs B; Petit C; Yoder BK; Chen P. 2008. Ciliary proteins link basal body polarization to planar cell polarity regulation. Nat Genet 40(1):69-77. [PubMed: 18066062]  [MGI Ref ID J:131308]

Kourepini E; Aggelakopoulou M; Alissafi T; Paschalidis N; Simoes DC; Panoutsakopoulou V. 2014. Osteopontin expression by CD103- dendritic cells drives intestinal inflammation. Proc Natl Acad Sci U S A 111(9):E856-65. [PubMed: 24550510]  [MGI Ref ID J:207403]

Kuhne C; Puk O; Graw J; Hrabe de Angelis M; Schutz G; Wurst W; Deussing JM. 2012. Visualizing corticotropin-releasing hormone receptor type 1 expression and neuronal connectivities in the mouse using a novel multifunctional allele. J Comp Neurol 520(14):3150-80. [PubMed: 22886732]  [MGI Ref ID J:187372]

Liu C; Bakeri H; Li T; Swaroop A. 2012. Regulation of retinal progenitor expansion by Frizzled receptors: implications for microphthalmia and retinal coloboma. Hum Mol Genet 21(8):1848-60. [PubMed: 22228100]  [MGI Ref ID J:181885]

Liu C; Wang Y; Smallwood PM; Nathans J. 2008. An essential role for Frizzled5 in neuronal survival in the parafascicular nucleus of the thalamus. J Neurosci 28(22):5641-53. [PubMed: 18509025]  [MGI Ref ID J:136390]

Lu TL; Chang JL; Liang CC; You LR; Chen CM. 2007. Tumor spectrum, tumor latency and tumor incidence of the pten-deficient mice. PLoS ONE 2(11):e1237. [PubMed: 18043744]  [MGI Ref ID J:130367]

Macfarlan TS; Gifford WD; Agarwal S; Driscoll S; Lettieri K; Wang J; Andrews SE; Franco L; Rosenfeld MG; Ren B; Pfaff SL. 2011. Endogenous retroviruses and neighboring genes are coordinately repressed by LSD1/KDM1A. Genes Dev 25(6):594-607. [PubMed: 21357675]  [MGI Ref ID J:169674]

Mangale VS; Hirokawa KE; Satyaki PR; Gokulchandran N; Chikbire S; Subramanian L; Shetty AS; Martynoga B; Paul J; Mai MV; Li Y; Flanagan LA; Tole S; Monuki ES. 2008. Lhx2 selector activity specifies cortical identity and suppresses hippocampal organizer fate. Science 319(5861):304-9. [PubMed: 18202285]  [MGI Ref ID J:130167]

Milosevic I; Giovedi S; Lou X; Raimondi A; Collesi C; Shen H; Paradise S; O'Toole E; Ferguson S; Cremona O; Camilli PD. 2011. Recruitment of endophilin to clathrin-coated pit necks is required for efficient vesicle uncoating after fission. Neuron 72(4):587-601. [PubMed: 22099461]  [MGI Ref ID J:178947]

Morioka S; Broglie P; Omori E; Ikeda Y; Takaesu G; Matsumoto K; Ninomiya-Tsuji J. 2014. TAK1 kinase switches cell fate from apoptosis to necrosis following TNF stimulation. J Cell Biol 204(4):607-23. [PubMed: 24535827]  [MGI Ref ID J:208251]

Morioka S; Inagaki M; Komatsu Y; Mishina Y; Matsumoto K; Ninomiya-Tsuji J. 2012. TAK1 kinase signaling regulates embryonic angiogenesis by modulating endothelial cell survival and migration. Blood 120(18):3846-57. [PubMed: 22972987]  [MGI Ref ID J:191285]

Nakatsu F; Baskin JM; Chung J; Tanner LB; Shui G; Lee SY; Pirruccello M; Hao M; Ingolia NT; Wenk MR; De Camilli P. 2012. PtdIns4P synthesis by PI4KIIIalpha at the plasma membrane and its impact on plasma membrane identity. J Cell Biol 199(6):1003-16. [PubMed: 23229899]  [MGI Ref ID J:195235]

Nichol PF; Corliss RF; Tyrrell JD; Graham B; Reeder A; Saijoh Y. 2011. Conditional mutation of fibroblast growth factor receptors 1 and 2 results in an omphalocele in mice associated with disruptions in ventral body wall muscle formation. J Pediatr Surg 46(1):90-6. [PubMed: 21238647]  [MGI Ref ID J:170635]

Olson LE ; Soriano P. 2009. Increased PDGFRalpha activation disrupts connective tissue development and drives systemic fibrosis. Dev Cell 16(2):303-13. [PubMed: 19217431]  [MGI Ref ID J:146617]

Ostrowski LE; Yin W; Rogers TD; Busalacchi KB; Chua M; O'Neal WK; Grubb BR. 2009. Conditional Deletion of Dnaic1 in a Murine Model of Primary Ciliary Dyskinesia Causes Chronic Rhinosinusitis. Am J Respir Cell Mol Biol :. [PubMed: 19675306]  [MGI Ref ID J:155730]

Park EJ; Grabinska KA; Guan Z; Stranecky V; Hartmannova H; Hodanova K; Baresova V; Sovova J; Jozsef L; Ondruskova N; Hansikova H; Honzik T; Zeman J; Hulkova H; Wen R; Kmoch S; Sessa WC. 2014. Mutation of Nogo-B receptor, a subunit of cis-prenyltransferase, causes a congenital disorder of glycosylation. Cell Metab 20(3):448-57. [PubMed: 25066056]  [MGI Ref ID J:215785]

Park JA; Sharif AS; Shiomi T; Kobzik L; Kasahara DI; Tschumperlin DJ; Voynow J; Drazen JM. 2013. Human neutrophil elastase-mediated goblet cell metaplasia is attenuated in TACE-deficient mice. Am J Physiol Lung Cell Mol Physiol 304(10):L701-7. [PubMed: 23564510]  [MGI Ref ID J:196680]

Park SO; Wankhede M; Lee YJ; Choi EJ; Fliess N; Choe SW; Oh SH; Walter G; Raizada MK; Sorg BS; Oh SP. 2009. Real-time imaging of de novo arteriovenous malformation in a mouse model of hereditary hemorrhagic telangiectasia. J Clin Invest 119(11):3487-96. [PubMed: 19805914]  [MGI Ref ID J:154620]

Penzo M; Molteni R; Suda T; Samaniego S; Raucci A; Habiel DM; Miller F; Jiang HP; Li J; Pardi R; Palumbo R; Olivotto E; Kew RR; Bianchi ME; Marcu KB. 2010. Inhibitor of NK-kappaB kinases alpha and beta are both essential for high mobility group box 1-mediated chemotaxis. J Immunol 184(8):4497-509. [PubMed: 20231695]  [MGI Ref ID J:159873]

Prashar P; Yadav PS; Samarjeet F; Bandyopadhyay A. 2014. Microarray meta-analysis identifies evolutionarily conserved BMP signaling targets in developing long bones. Dev Biol 389(2):192-207. [PubMed: 24583261]  [MGI Ref ID J:209351]

Qian D; Jones C; Rzadzinska A; Mark S; Zhang X; Steel KP; Dai X; Chen P. 2007. Wnt5a functions in planar cell polarity regulation in mice. Dev Biol 306(1):121-33. [PubMed: 17433286]  [MGI Ref ID J:122585]

Roy A; de Melo J; Chaturvedi D; Thein T; Cabrera-Socorro A; Houart C; Meyer G; Blackshaw S; Tole S. 2013. LHX2 is necessary for the maintenance of optic identity and for the progression of optic morphogenesis. J Neurosci 33(16):6877-84. [PubMed: 23595746]  [MGI Ref ID J:196967]

Sabharwal P; Lee C; Park S; Rao M; Sockanathan S. 2011. GDE2 regulates subtype-specific motor neuron generation through inhibition of Notch signaling. Neuron 71(6):1058-70. [PubMed: 21943603]  [MGI Ref ID J:178550]

Sajgo S; Ghinia MG; Shi M; Liu P; Dong L; Parmhans N; Popescu O; Badea TC. 2014. Dre - Cre sequential recombination provides new tools for retinal ganglion cell labeling and manipulation in mice. PLoS One 9(3):e91435. [PubMed: 24608965]  [MGI Ref ID J:215125]

Schulze RJ; Weller SG; Schroeder B; Krueger EW; Chi S; Casey CA; McNiven MA. 2013. Lipid droplet breakdown requires dynamin 2 for vesiculation of autolysosomal tubules in hepatocytes. J Cell Biol 203(2):315-26. [PubMed: 24145164]  [MGI Ref ID J:207947]

Shen H; Ferguson SM; Dephoure N; Park R; Yang Y; Volpicelli-Daley L; Gygi S; Schlessinger J; De Camilli P. 2011. Constitutive activated Cdc42-associated kinase (Ack) phosphorylation at arrested endocytic clathrin-coated pits of cells that lack dynamin. Mol Biol Cell 22(4):493-502. [PubMed: 21169560]  [MGI Ref ID J:182890]

Shetty AS; Godbole G; Maheshwari U; Padmanabhan H; Chaudhary R; Muralidharan B; Hou PS; Monuki ES; Kuo HC; Rema V; Tole S. 2013. Lhx2 regulates a cortex-specific mechanism for barrel formation. Proc Natl Acad Sci U S A 110(50):E4913-21. [PubMed: 24262147]  [MGI Ref ID J:205196]

Shiomi T; Tschumperlin DJ; Park JA; Sunnarborg SW; Horiuchi K; Blobel CP; Drazen JM. 2011. TNF-alpha-converting enzyme/a disintegrin and metalloprotease-17 mediates mechanotransduction in murine tracheal epithelial cells. Am J Respir Cell Mol Biol 45(2):376-85. [PubMed: 21097655]  [MGI Ref ID J:186821]

Simons BW; Hurley PJ; Huang Z; Ross AE; Miller R; Marchionni L; Berman DM; Schaeffer EM. 2012. Wnt signaling though beta-catenin is required for prostate lineage specification. Dev Biol 371(2):246-55. [PubMed: 22960283]  [MGI Ref ID J:190538]

Straessler KM; Jones KB; Hu H; Jin H; van de Rijn M; Capecchi MR. 2013. Modeling clear cell sarcomagenesis in the mouse: cell of origin differentiation state impacts tumor characteristics. Cancer Cell 23(2):215-27. [PubMed: 23410975]  [MGI Ref ID J:194308]

Takaesu G; Inagaki M; Takubo K; Mishina Y; Hess PR; Dean GA; Yoshimura A; Matsumoto K; Suda T; Ninomiya-Tsuji J. 2012. TAK1 (MAP3K7) signaling regulates hematopoietic stem cells through TNF-dependent and -independent mechanisms. PLoS One 7(11):e51073. [PubMed: 23226465]  [MGI Ref ID J:194994]

Takai H; Wang RC; Takai KK; Yang H; de Lange T. 2007. Tel2 regulates the stability of PI3K-related protein kinases. Cell 131(7):1248-59. [PubMed: 18160036]  [MGI Ref ID J:141633]

Takai H; Xie Y; de Lange T; Pavletich NP. 2010. Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes. Genes Dev 24(18):2019-30. [PubMed: 20801936]  [MGI Ref ID J:164024]

Tran PV; Talbott GC; Turbe-Doan A; Jacobs DT; Schonfeld MP; Silva LM; Chatterjee A; Prysak M; Allard BA; Beier DR. 2014. Downregulating Hedgehog Signaling Reduces Renal Cystogenic Potential of Mouse Models. J Am Soc Nephrol :. [PubMed: 24700869]  [MGI Ref ID J:213263]

Van Handel B; Montel-Hagen A; Sasidharan R; Nakano H; Ferrari R; Boogerd CJ; Schredelseker J; Wang Y; Hunter S; Org T; Zhou J; Li X; Pellegrini M; Chen JN; Orkin SH; Kurdistani SK; Evans SM; Nakano A; Mikkola HK. 2012. Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium. Cell 150(3):590-605. [PubMed: 22863011]  [MGI Ref ID J:187883]

Vassen L; Beauchemin H; Lemsaddek W; Krongold J; Trudel M; Moroy T. 2014. Growth factor independence 1b (gfi1b) is important for the maturation of erythroid cells and the regulation of embryonic globin expression. PLoS One 9(5):e96636. [PubMed: 24800817]  [MGI Ref ID J:217367]

Vernia S; Cavanagh-Kyros J; Barrett T; Jung DY; Kim JK; Davis RJ. 2013. Diet-induced obesity mediated by the JNK/DIO2 signal transduction pathway. Genes Dev 27(21):2345-55. [PubMed: 24186979]  [MGI Ref ID J:202882]

Wakabayashi N; Shin S; Slocum SL; Agoston ES; Wakabayashi J; Kwak MK; Misra V; Biswal S; Yamamoto M; Kensler TW. 2010. Regulation of notch1 signaling by nrf2: implications for tissue regeneration. Sci Signal 3(130):ra52. [PubMed: 20628156]  [MGI Ref ID J:185406]

Wang Q; Huang C; Xue M; Zhang X. 2011. Expression of endogenous BMP-2 in periosteal progenitor cells is essential for bone healing. Bone 48(3):524-32. [PubMed: 21056707]  [MGI Ref ID J:170281]

Wang R; Dillon CP; Shi LZ; Milasta S; Carter R; Finkelstein D; McCormick LL; Fitzgerald P; Chi H; Munger J; Green DR. 2011. The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation. Immunity 35(6):871-82. [PubMed: 22195744]  [MGI Ref ID J:179281]

Weinlich R; Oberst A; Dillon CP; Janke LJ; Milasta S; Lukens JR; Rodriguez DA; Gurung P; Savage C; Kanneganti TD; Green DR. 2013. Protective roles for caspase-8 and cFLIP in adult homeostasis. Cell Rep 5(2):340-8. [PubMed: 24095739]  [MGI Ref ID J:203778]

Ye X; Wang Y; Rattner A; Nathans J. 2011. Genetic mosaic analysis reveals a major role for frizzled 4 and frizzled 8 in controlling ureteric growth in the developing kidney. Development 138(6):1161-72. [PubMed: 21343368]  [MGI Ref ID J:170839]

Yoo SE; Chen L; Na R; Liu Y; Rios C; Van Remmen H; Richardson A; Ran Q. 2012. Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain. Free Radic Biol Med 52(9):1820-7. [PubMed: 22401858]  [MGI Ref ID J:183246]

Yun S; Saijoh Y; Hirokawa KE; Kopinke D; Murtaugh LC; Monuki ES; Levine EM. 2009. Lhx2 links the intrinsic and extrinsic factors that control optic cup formation. Development 136(23):3895-906. [PubMed: 19906857]  [MGI Ref ID J:154982]

Zhao F; Edwards R; Dizon D; Afrasiabi K; Mastroianni JR; Geyfman M; Ouellette AJ; Andersen B; Lipkin SM. 2010. Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2-/- mice. Dev Biol 338(2):270-9. [PubMed: 20025862]  [MGI Ref ID J:156704]

Zheng L; Njauw CN; Martins-Green M. 2007. A hCXCR1 transgenic mouse model containing a conditional color-switching system for imaging of hCXCL8/IL-8 functions in vivo. J Leukoc Biol 82(5):1247-56. [PubMed: 17704296]  [MGI Ref ID J:127327]

Zhou X; Xiang Y; Ding X; Garrard WT. 2013. Loss of an Igkappa gene enhancer in mature B cells results in rapid gene silencing and partial reversible dedifferentiation. Mol Cell Biol 33(10):2091-101. [PubMed: 23508106]  [MGI Ref ID J:204030]

Zhu Y; Chen J; Liang C; Zong L; Chen J; Jones RO; Zhao HB. 2015. Connexin26 (GJB2) deficiency reduces active cochlear amplification leading to late-onset hearing loss. Neuroscience 284:719-29. [PubMed: 25451287]  [MGI Ref ID J:221450]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX12

Colony Maintenance

Breeding & HusbandryThis strain originated and is maintained on a B6;129 background as a homozygote.
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $246.90Female or MaleHomozygous for Gt(ROSA)26Sortm1(cre/ERT)Nat  
Price per Pair (US dollars $)Pair Genotype
$493.80Homozygous for Gt(ROSA)26Sortm1(cre/ERT)Nat x Homozygous for Gt(ROSA)26Sortm1(cre/ERT)Nat  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Cryopreserved

Frozen Products

Price (US dollars $)
Frozen Embryo $1725.00

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $321.00Female or MaleHomozygous for Gt(ROSA)26Sortm1(cre/ERT)Nat  
Price per Pair (US dollars $)Pair Genotype
$642.00Homozygous for Gt(ROSA)26Sortm1(cre/ERT)Nat x Homozygous for Gt(ROSA)26Sortm1(cre/ERT)Nat  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Cryopreserved

Frozen Products

Price (US dollars $)
Frozen Embryo $2242.50

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

  Control
   101045 B6129SF2/J (approximate)
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Mice are subject to US Patent 6040430.
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


(6.10)