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| These R26CreER mutant mice have a tamoxifen-inducible Cre-mediated recombination system driven by the endogenous mouse Gt(ROSA)26Sor promoter. When crossed with a strain containing a loxP site-flanked sequence of interest, this mutant is useful for generating tamoxifen-induced, Cre-mediated targeted deletions. | |||||||||||||||||||
- Description
- Disease & phenotype
- Genes & alleles
- Genotyping
- Health & care
- References
- Pricing & purchasing
- Terms of use
Description
Strain Information
Former Names B6;129-Gt(ROSA)26Sortm1(cre/Esr1)Nat/J (Changed: 30-MAR-10 ) Type Mutant Stock; Targeted Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Mating System Homozygote x Homozygote (Female x Male) 01-MAR-06 Species laboratory mouse Generation F?+F11 (30-DEC-08)
Generation DefinitionsDonating Investigator Jeremy Nathans, Johns Hopkins University Description
These R26CreER mutant mice have a tamoxifen-inducible Cre-mediated recombination system driven by the endogenous mouse Gt(ROSA)26Sor promoter. The mutant allele consists of a fusion product involving Cre recombinase and an altered version of the mouse estrogen receptor ligand binding domain. The mutant ligand binding domain does not bind natural ligand at physiological concentrations but will bind the synthetic ligand, 4-hydroxytamoxifen. Restricted to the cytoplasm, the CRE/ESR1 protein can only gain access to the nuclear compartment to mediate recombination after exposure to tamoxifen. Tamoxifen administration will also induce Cre recombination in the developing embryos of treated mothers. When crossed with a strain containing a loxP site-flanked sequence of interest, this mutant is useful for generating tamoxifen-induced, Cre-mediated targeted deletions. Homozygous mutant mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities.Development
A targeting vector containing a PGK-neo cassette and Cre recombinase/estrogen receptor ligand-binding domain fusion protein sequence was used to insert the fusion protein into a site located within intron 1 of the GT(ROSA)26Sor locus. The construct was introduced into 129X1/SvJ x 129S1/Sv-derived R1-derived embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6 blastocysts. Correctly targeted ES cells were injected into C57BL/6J blastocysts to obtain chimeric animals.
Control Information
| Control | ||
|---|---|---|
| 101045 B6129SF2/J | (approximate) | |
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of Gt(ROSA)26Sor
View Strains carrying other alleles of Gt(ROSA)26Sor (130 strains)
Additional Web Information
Introduction to Cre-lox technology
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1(cre/ERT)Nat
B6.129-Gt(ROSA)26Sortm1(cre/Esr1)Nat
- normal phenotype
- no abnormal phenotype detected (MGI Ref ID J:84747)
This mouse can be used to support research in many areas including:
cre relatedResearch Tools
Cre-lox System
Cre Recombinase Expression
Cre Recombinase Expression: Inducible
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Gt(ROSA)26Sortm1(cre/ERT)Nat relatedResearch Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Developmental Biology Research
Internal/Organ Defects
ovary; uterus
Internal/Organ Research
Other Organ Defects
Reproductive Biology Research
Developmental Defects Affecting Gonads
germ cell deficient
Fertility Defects
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Gt(ROSA)26Sortm1(cre/ERT)Nat | ||
|---|---|---|---|
| Allele Name | targeted mutation 1, Jeremy Nathans | ||
| Allele Type | Targeted (knock-in) | ||
| Common Name(s) | CreERT1; Gt(ROSA)26Sortm1(cre/Esr1)Nat; R26CreER; R26ERCre; R26RNatCre; | ||
| Mutation Made By | Tudor Badea, Johns Hopkins University | ||
| Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> | ||
| ES Cell Line Name | R1 | ||
| ES Cell Line Strain | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> | ||
| Site of Expression | tamoxifen-inducible cre; when crossed with a strain containing a loxP site-flanked sequence of interest, this mutant is useful for generating tamoxifen-induced, Cre-mediated targeted deletions | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Driver Note | Gt(ROSA)26Sor | ||
| Inducible Note | induced by tamoxifen | ||
| Molecular Note | A cDNA fragment encoding a fusion protein comprised of cre recombinase and the ligand binding domain of Esr1 was inserted at the endogenous locus via homologous recombination. The initiator methionine was placed in an optimal translational context, allowing for near ubiquitous expression via the endogenous promoter. Activation of cre recombinase activity is dependent on the administration of 4-HO-tamoxifen. [MGI Ref ID J:84747] | ||
| Gene Symbol and Name | Gt(ROSA)26Sor, gene trap ROSA 26, Philippe Soriano | ||
| Chromosome | 6 | ||
| Gene Common Name(s) | AV258896; Gtrgeo26; Gtrosa26; R26; ROSA26; beta geo; expressed sequence AV258896; gene trap ROSA 26; gene trap ROSA b-geo 26; | ||
Genotyping
Genotyping Information
Genotyping Protocols
Gt(Rosa)26Sortm1(cre/Esr1)Nat, Melt Curve Analysis
Gt(ROSA)26Sortm1(cre/Esr1)Nat, Separated PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Badea TC; Wang Y; Nathans J. 2003. A noninvasive genetic/pharmacologic strategy for visualizing cell morphology and clonal relationships in the mouse. J Neurosci 23(6):2314-22. [PubMed: 12657690] [MGI Ref ID J:84747]
Additional References
Gt(ROSA)26Sortm1(cre/ERT)Nat relatedBadea TC; Cahill H; Ecker J; Hattar S; Nathans J. 2009. Distinct roles of transcription factors brn3a and brn3b in controlling the development, morphology, and function of retinal ganglion cells. Neuron 61(6):852-64. [PubMed: 19323995] [MGI Ref ID J:147350]
Badea TC; Hua ZL; Smallwood PM; Williams J; Rotolo T; Ye X; Nathans J. 2009. New mouse lines for the analysis of neuronal morphology using CreER(T)/loxP-directed sparse labeling. PLoS One 4(11):e7859. [PubMed: 19924248] [MGI Ref ID J:155417]
Badea TC; Williams J; Smallwood P; Shi M; Motajo O; Nathans J. 2012. Combinatorial expression of brn3 transcription factors in somatosensory neurons: genetic and morphologic analysis. J Neurosci 32(3):995-1007. [PubMed: 22262898] [MGI Ref ID J:179888]
Bondar T; Medzhitov R. 2010. p53-mediated hematopoietic stem and progenitor cell competition. Cell Stem Cell 6(4):309-22. [PubMed: 20362536] [MGI Ref ID J:158953]
Cellurale C; Girnius N; Jiang F; Cavanagh-Kyros J; Lu S; Garlick DS; Mercurio AM; Davis RJ. 2012. Role of JNK in mammary gland development and breast cancer. Cancer Res 72(2):472-81. [PubMed: 22127926] [MGI Ref ID J:181146]
Cellurale C; Sabio G; Kennedy NJ; Das M; Barlow M; Sandy P; Jacks T; Davis RJ. 2011. Requirement of c-Jun NH2-Terminal Kinase for Ras-Initiated Tumor Formation. Mol Cell Biol 31(7):1565-76. [PubMed: 21282468] [MGI Ref ID J:170101]
Chiang PM; Ling J; Jeong YH; Price DL; Aja SM; Wong PC. 2010. Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism. Proc Natl Acad Sci U S A 107(37):16320-4. [PubMed: 20660762] [MGI Ref ID J:164406]
Chong MM; Rasmussen JP; Rundensky AY; Littman DR. 2008. The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease. J Exp Med 205(9):2005-17. [PubMed: 18725527] [MGI Ref ID J:138683]
Chong MM; Zhang G; Cheloufi S; Neubert TA; Hannon GJ; Littman DR. 2010. Canonical and alternate functions of the microRNA biogenesis machinery. Genes Dev 24(17):1951-60. [PubMed: 20713509] [MGI Ref ID J:163823]
Cornacchia D; Dileep V; Quivy JP; Foti R; Tili F; Santarella-Mellwig R; Antony C; Almouzni G; Gilbert DM; Buonomo SB. 2012. Mouse Rif1 is a key regulator of the replication-timing programme in mammalian cells. EMBO J 31(18):3678-90. [PubMed: 22850673] [MGI Ref ID J:188030]
Cowley DO; Rivera-Perez JA; Schliekelman M; He YJ; Oliver TG; Lu L; O'Quinn R; Salmon ED; Magnuson T; Van Dyke T. 2009. Aurora-A kinase is essential for bipolar spindle formation and early development. Mol Cell Biol 29(4):1059-71. [PubMed: 19075002] [MGI Ref ID J:145744]
Das M; Jiang F; Sluss HK; Zhang C; Shokat KM; Flavell RA; Davis RJ. 2007. Suppression of p53-dependent senescence by the JNK signal transduction pathway. Proc Natl Acad Sci U S A 104(40):15759-64. [PubMed: 17893331] [MGI Ref ID J:131766]
Doan LT; Javier AL; Furr NM; Nguyen KL; Cho KW; Monuki ES. 2012. A Bmp reporter with ultrasensitive characteristics reveals that high Bmp signaling is not required for cortical hem fate. PLoS One 7(9):e44009. [PubMed: 22984456] [MGI Ref ID J:192898]
Dubois CL; Shih HP; Seymour PA; Patel NA; Behrmann JM; Ngo V; Sander M. 2011. Sox9-haploinsufficiency causes glucose intolerance in mice. PLoS One 6(8):e23131. [PubMed: 21829703] [MGI Ref ID J:176523]
Ferguson SM; Raimondi A; Paradise S; Shen H; Mesaki K; Ferguson A; Destaing O; Ko G; Takasaki J; Cremona O; O' Toole E; De Camilli P. 2009. Coordinated actions of actin and BAR proteins upstream of dynamin at endocytic clathrin-coated pits. Dev Cell 17(6):811-22. [PubMed: 20059951] [MGI Ref ID J:161127]
Flora A; Klisch TJ; Schuster G; Zoghbi HY. 2009. Deletion of Atoh1 disrupts Sonic Hedgehog signaling in the developing cerebellum and prevents medulloblastoma. Science 326(5958):1424-7. [PubMed: 19965762] [MGI Ref ID J:155047]
Furumoto Y; Charles N; Olivera A; Leung WH; Dillahunt S; Sargent JL; Tinsley K; Odom S; Scott E; Wilson TM; Ghoreschi K; Kneilling M; Chen M; Lee DM; Bolland S; Rivera J. 2011. PTEN deficiency in mast cells causes a mastocytosis-like proliferative disease that heightens allergic responses and vascular permeability. Blood 118(20):5466-75. [PubMed: 21926349] [MGI Ref ID J:178784]
Gantier MP; McCoy CE; Rusinova I; Saulep D; Wang D; Xu D; Irving AT; Behlke MA; Hertzog PJ; Mackay F; Williams BR. 2011. Analysis of microRNA turnover in mammalian cells following Dicer1 ablation. Nucleic Acids Res 39(13):5692-703. [PubMed: 21447562] [MGI Ref ID J:174036]
Ghosh S; Lau H; Simons BW; Powell JD; Meyers DJ; De Marzo AM; Berman DM; Lotan TL. 2011. PI3K/mTOR signaling regulates prostatic branching morphogenesis. Dev Biol 360(2):329-42. [PubMed: 22015718] [MGI Ref ID J:178714]
Haldar M; Hedberg ML; Hockin MF; Capecchi MR. 2009. A CreER-based random induction strategy for modeling translocation-associated sarcomas in mice. Cancer Res 69(8):3657-64. [PubMed: 19351831] [MGI Ref ID J:147728]
Jones C; Roper VC; Foucher I; Qian D; Banizs B; Petit C; Yoder BK; Chen P. 2008. Ciliary proteins link basal body polarization to planar cell polarity regulation. Nat Genet 40(1):69-77. [PubMed: 18066062] [MGI Ref ID J:131308]
Kuhne C; Puk O; Graw J; Hrabe de Angelis M; Schutz G; Wurst W; Deussing JM. 2012. Visualizing corticotropin-releasing hormone receptor type 1 expression and neuronal connectivities in the mouse using a novel multifunctional allele. J Comp Neurol 520(14):3150-80. [PubMed: 22886732] [MGI Ref ID J:187372]
Liu C; Bakeri H; Li T; Swaroop A. 2012. Regulation of retinal progenitor expansion by Frizzled receptors: implications for microphthalmia and retinal coloboma. Hum Mol Genet 21(8):1848-60. [PubMed: 22228100] [MGI Ref ID J:181885]
Liu C; Wang Y; Smallwood PM; Nathans J. 2008. An essential role for Frizzled5 in neuronal survival in the parafascicular nucleus of the thalamus. J Neurosci 28(22):5641-53. [PubMed: 18509025] [MGI Ref ID J:136390]
Lu TL; Chang JL; Liang CC; You LR; Chen CM. 2007. Tumor spectrum, tumor latency and tumor incidence of the pten-deficient mice. PLoS ONE 2(11):e1237. [PubMed: 18043744] [MGI Ref ID J:130367]
Macfarlan TS; Gifford WD; Agarwal S; Driscoll S; Lettieri K; Wang J; Andrews SE; Franco L; Rosenfeld MG; Ren B; Pfaff SL. 2011. Endogenous retroviruses and neighboring genes are coordinately repressed by LSD1/KDM1A. Genes Dev 25(6):594-607. [PubMed: 21357675] [MGI Ref ID J:169674]
Mangale VS; Hirokawa KE; Satyaki PR; Gokulchandran N; Chikbire S; Subramanian L; Shetty AS; Martynoga B; Paul J; Mai MV; Li Y; Flanagan LA; Tole S; Monuki ES. 2008. Lhx2 selector activity specifies cortical identity and suppresses hippocampal organizer fate. Science 319(5861):304-9. [PubMed: 18202285] [MGI Ref ID J:130167]
Milosevic I; Giovedi S; Lou X; Raimondi A; Collesi C; Shen H; Paradise S; O'Toole E; Ferguson S; Cremona O; Camilli PD. 2011. Recruitment of endophilin to clathrin-coated pit necks is required for efficient vesicle uncoating after fission. Neuron 72(4):587-601. [PubMed: 22099461] [MGI Ref ID J:178947]
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Nakatsu F; Baskin JM; Chung J; Tanner LB; Shui G; Lee SY; Pirruccello M; Hao M; Ingolia NT; Wenk MR; De Camilli P. 2012. PtdIns4P synthesis by PI4KIIIalpha at the plasma membrane and its impact on plasma membrane identity. J Cell Biol 199(6):1003-16. [PubMed: 23229899] [MGI Ref ID J:195235]
Nichol PF; Corliss RF; Tyrrell JD; Graham B; Reeder A; Saijoh Y. 2011. Conditional mutation of fibroblast growth factor receptors 1 and 2 results in an omphalocele in mice associated with disruptions in ventral body wall muscle formation. J Pediatr Surg 46(1):90-6. [PubMed: 21238647] [MGI Ref ID J:170635]
Olson LE ; Soriano P. 2009. Increased PDGFRalpha activation disrupts connective tissue development and drives systemic fibrosis. Dev Cell 16(2):303-13. [PubMed: 19217431] [MGI Ref ID J:146617]
Ostrowski LE; Yin W; Rogers TD; Busalacchi KB; Chua M; O'Neal WK; Grubb BR. 2009. Conditional Deletion of Dnaic1 in a Murine Model of Primary Ciliary Dyskinesia Causes Chronic Rhinosinusitis. Am J Respir Cell Mol Biol :. [PubMed: 19675306] [MGI Ref ID J:155730]
Park SO; Wankhede M; Lee YJ; Choi EJ; Fliess N; Choe SW; Oh SH; Walter G; Raizada MK; Sorg BS; Oh SP. 2009. Real-time imaging of de novo arteriovenous malformation in a mouse model of hereditary hemorrhagic telangiectasia. J Clin Invest 119(11):3487-96. [PubMed: 19805914] [MGI Ref ID J:154620]
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Qian D; Jones C; Rzadzinska A; Mark S; Zhang X; Steel KP; Dai X; Chen P. 2007. Wnt5a functions in planar cell polarity regulation in mice. Dev Biol 306(1):121-33. [PubMed: 17433286] [MGI Ref ID J:122585]
Sabharwal P; Lee C; Park S; Rao M; Sockanathan S. 2011. GDE2 regulates subtype-specific motor neuron generation through inhibition of Notch signaling. Neuron 71(6):1058-70. [PubMed: 21943603] [MGI Ref ID J:178550]
Shen H; Ferguson SM; Dephoure N; Park R; Yang Y; Volpicelli-Daley L; Gygi S; Schlessinger J; De Camilli P. 2011. Constitutive activated Cdc42-associated kinase (Ack) phosphorylation at arrested endocytic clathrin-coated pits of cells that lack dynamin. Mol Biol Cell 22(4):493-502. [PubMed: 21169560] [MGI Ref ID J:182890]
Shiomi T; Tschumperlin DJ; Park JA; Sunnarborg SW; Horiuchi K; Blobel CP; Drazen JM. 2011. TNF-alpha-converting enzyme/a disintegrin and metalloprotease-17 mediates mechanotransduction in murine tracheal epithelial cells. Am J Respir Cell Mol Biol 45(2):376-85. [PubMed: 21097655] [MGI Ref ID J:186821]
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Takaesu G; Inagaki M; Takubo K; Mishina Y; Hess PR; Dean GA; Yoshimura A; Matsumoto K; Suda T; Ninomiya-Tsuji J. 2012. TAK1 (MAP3K7) signaling regulates hematopoietic stem cells through TNF-dependent and -independent mechanisms. PLoS One 7(11):e51073. [PubMed: 23226465] [MGI Ref ID J:194994]
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Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX12
Colony Maintenance
Breeding & Husbandry This strain originated and is maintained on a B6;129 background as a homozygote. Mating System Homozygote x Homozygote (Female x Male) 01-MAR-06 Diet Information LabDiet® 5K52/5K67
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $232.00 Female or Male Homozygous for Gt(ROSA)26Sortm1(cre/ERT)Nat
Price per Pair (US dollars $) Pair Genotype $464.00 Homozygous for Gt(ROSA)26Sortm1(cre/ERT)Nat x Homozygous for Gt(ROSA)26Sortm1(cre/ERT)Nat Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
| Pricing for International shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $301.60 Female or Male Homozygous for Gt(ROSA)26Sortm1(cre/ERT)Nat
Price per Pair (US dollars $) Pair Genotype $603.20 Homozygous for Gt(ROSA)26Sortm1(cre/ERT)Nat x Homozygous for Gt(ROSA)26Sortm1(cre/ERT)Nat Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
|
|
|
Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| 101045 B6129SF2/J | (approximate) | |
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
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In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.