Strain Name: |
B6EiC3Sn-Rb(12.T171665Dn)2Cje/CjeDn |
|---|---|
Stock Number: |
004850 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Former Name |
B6EiC3Sn-Rb(12.Ts171665Dn)2Cje/CjeDn (Changed: 09-MAY-08
) |
|
B6EiC3Sn-Rb(12.Ts65Dn)1Cje (Changed: 29-MAR-05
) | |
| Genes & Alleles | Rb(12.T171665Dn)2Cje; |
Product Information
Strain Details
Type Chromosome Aberration Additional information on Mice with Chromosomal Aberrations. Type JAX® GEMM® Strain - Mutant Strain Additional information on JAX® GEMM® Strains. Type Robertsonian Additional information on Mice with Chromosomal Aberrations. Species laboratory mouse Generation N12p Appearance
agouti or black
Related Genotype: A/A or A/a or a/aImportant Note
Pde6brd1, the recessive retinal degeneration 1 mutation, is segregating in this colony. Animals that are homozygous for rd1 will be blind.Strain Description
Like B6EiC3Sn a/A - Ts(1716)65Dn (Stock No. 001924), this strain has three copies of most of the genes on mouse Chromosome 16 that are homologues of human Chromosome 21 genes. Transmission of the chromosome 16 segmental trisomy through the female germline is significantly improved over Ts65Dn (43% versus 24%). Dendritic spines on granule cells in the fascia dentata are enlarged in size and decreased in density (Villar AJ, et al. 2005). Unlike Ts65Dn, males are fertile. Mice are 20% smaller in size than controls. This strain serves a model for Down syndrome.Strain Development
This strain is the result of a mating between a female B6EiC3Sn a/A - Ts(1716)65Dn (Stock No. 001924) and a diploid B6EiC3SnF1 male. The founder female carried a spontaneous fusion in which the small marker chromosome carrying the distal end of chromosome 16 in B6EiC3Sn a/A - Ts(1716)65Dn translocated to chromosome 12 forming a Robertsonian fusion chromosome. Quantitative PCR confirmed the triplication of chromosome 16 genes from App to Mx1.
Related Disease (OMIM) Terms |
Mammalian Phenotype Terms assigned by genotype |
Gene & Allele Details
| Allele Symbol | Rb(12.T171665Dn)2Cje | ||
|---|---|---|---|
| Allele Name | Robertsonian translocation, Chr 12 and T17<16>Dn, Charles J Epstein 2 | ||
| Common Name(s) | Ts(Rb(12.1716))2Cje; | ||
| Molecular Note | A female mouse with 40 chromosomes and 41 arms was detected by chromosome analysis of progeny from T171665Dn mice. This mouse had a unique biarmed chromosome that appeared to be the result of a fusion between chromosome 12 and the marker chromosome T(1716)65Dn. | ||
Control Information
| Control | ||
|---|---|---|
| Littermates from the colony | ||
| 001875 B6EiC3SnF1/J | ||
| Considerations for Choosing Controls | ||
Related Strains
Robertsonian Chromosome
View Robertsonian Chromosome (69 strains)
Research Applications
This mouse can be used to support research in many areas including:
Neurobiology Research
Behavioral and Learning Defects (Down syndrome)
References
Selected Reference(s)
Additional ReferencesVillar AJ; Belichenko PV; Gillespie AM; Kozy HM; Mobley WC; Epstein CJ. 2005. Identification and characterization of a new Down syndrome model, Ts[Rb(12.1716)]2Cje, resulting from a spontaneous Robertsonian fusion between T(171)65Dn and mouse chromosome 12. Mamm Genome 16(2):79-90. [PubMed: 15859352] [MGI Ref ID J:96650]
Price and Supply Information
| Strain Name: | B6EiC3Sn-Rb(12.T171665Dn)2Cje/CjeDn |
| Stock Number: | 004850 |
Price Details
IMPORTANT NOTE: Prices are based on shipping destination. To view prices, select your shipping destination.
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Request Form |
Strain from the Cytogenetic Models Resource. First time use requires submission of a Request Form, please inquire. |
| Licensing | See General Terms and Conditions below |
| Control Information | View Control Information in Strain Details. |
General Terms and Conditions
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The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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