Strain Name:

B6EiC3Sn-Ts(16C-tel)1Cje/DnJ

Stock Number:

004861

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Availability:

Cryopreserved - Ready for recovery

Use Restrictions Apply, see Terms of Use

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names B6EiC3Sn-Ts(16C-tel)1Cje    (Changed: 11-JAN-10 )
B6EiC3Sn-Ts(1216C-tel)1Cje    (Changed: 17-FEB-05 )
B6Ei;C3Sn-Ts(1216C-tel)1Cje    (Changed: 15-DEC-04 )
Type Chromosome Aberration; Translocation; Trisomy;
Additional information on Mice with Chromosomal Aberrations.
Type Mutant Stock;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse

Important Note
Pde6brd1, the recessive retinal degeneration 1 mutation, is segregating in this colony. Animals that are homozygous for rd1 will be blind.

Description
Ts(16C-tel)1Cje trisomic mice display decreased exploratory behavior and have spatial learning deficits detectable in the hidden platform and probe versions of the Morris water maze. These learning deficits are less severe than those of mice carrying Ts(1716)Dn (Ts65Dn, Stock No. 001924 or 005252) with a larger distal Chr 16 translocation. The degeneration of basal forebrain cholinergic neurons that is found in Ts65Dn trisomic mice has not been found by six months of age in mice carrying Ts(16C-tel)1Cje. Additionally, the male sterility found in Ts65Dn mice is not a phenotype associated with Ts(16C-tel)1Cje (Sago et al., 1998). Despite having fewer trisomic genes, Ts(16C-tel)1Cje carriers display much of the same craniofacial dysmorphology as that found in Ts(1716)Dn, which includes brachycephaly, reduced interorbital breadth, and smaller mandible (Richtsmeier et al., 2002).

Development
The Ts(16C-tel)1Cje trisomy was derived from a chromosomal translocation that was identified in the Laboratory of Dr. Charles Epstein during the screening that followed the creation of the tm1Cje targeted mutation of Sod1 on Chr 16. This targeted disruption was done in CB1-4 ES cells which were derived from the embryos of a C57BL/6J female bred to an (Rb(11.16)2H x Rb(16.17)32Lub) F1 male, and the founders were backcrossed to CD1 for several generations. In these progeny, a sub-population of mice was found that carried the neomycin resistance gene indicative of the targeted disruption of Sod1 but the mice had normal levels of copper-zinc superoxide dismutase activity. FISH analysis revealed an Sod1tm1Cje-bearing translocation of distal Chr 16 onto Chr 12, which was named T(12;16)1Cje (Stock No. 004838). By breeding translocation carriers to wild-type mice, a partial trisomy line (designated Ts(16C-tel)1Cje) was generated harboring two wild-type Chr 16 copies and an additional copy of distal Chr 16 translocated onto Chr 12. Further analysis also reveals a small deletion of the telomeric part of Chr 12, with a translocation breakpoint between positions 119,278,499 and 119,289,499, in the Dnahc11 gene, between exons 35 and 41. Approximately half of this gene is truncated, leading to a monosomy that encompasses all the genes located downstream toward the telomeric end of mouse Chr 12.

The Ts(16C-tel)1Cje strain was then backcrossed onto C57BL/6J by the Donating Investigator. In 1997, N10 carriers were sent to The Jackson Laboratory where they were backcrossed to C57BL/6J for 9 generations and then to C57BL/6JEiJ (003645) for several more generations. However, viability on the inbred background was severely reduced. Therefore, it was bred to B6EiC3SnF1/J (001875) mice henceforth to produce the current Ts(16C-tel)1Cje strain (004861), which has a genetic background comparable to that of the Ts65Dn trisomic strains (001924 and 005252).

In 2007, embryos were generated for cryopreservation via in vitro fertilization using B6EiC3SnF1/J females and trisomic males.

Control Information

  Control
   Wild-type littermate
 
  Considerations for Choosing Controls

Related Strains

View Trisomies     (2 strains)

Strains carrying   Ts(16C-tel)1Cje allele
004838   B6.Cg-T(12;16)1Cje/CjeDnJ
View Strains carrying   Ts(16C-tel)1Cje     (1 strain)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Characteristics of this human disease are associated with transgenes and other mutation types in the mouse.
Down Syndrome
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Ts(16C-tel)1Cje/0

        involves: C3H/HeSnJ * C57BL/6J * Rb(11.16)2H * Rb(16.17)32Lub
  • reproductive system phenotype
  • decreased testis weight
    • slightly smaller testes than controls   (MGI Ref ID J:117029)
  • oligozoospermia
    • sperm concentration was reduced below controls   (MGI Ref ID J:117029)
  • reduced male fertility
    • reduced fertility but five of six males produced plugs and three sired pups   (MGI Ref ID J:117029)
  • endocrine/exocrine gland phenotype
  • decreased testis weight
    • slightly smaller testes than controls   (MGI Ref ID J:117029)

Ts(16C-tel)1Cje/0

        involves: C3H/HeSnJ * C57BL/6J * CD-1 * Rb(16.17)32Lub * STOCK Rb(11.16)2H/H
  • behavior/neurological phenotype
  • abnormal spatial learning
    • in a hidden platform test and reverse platform test of a Morris water maze, mice exhibit impaired performance compared to wild-type mice   (MGI Ref ID J:47907)
    • learning over a 3 month period in the Morris water maze tests improves but remains impaired compared to in wild-type mice   (MGI Ref ID J:47907)
  • nervous system phenotype
  • *normal* nervous system phenotype
    • adult brain gross morphology is normal   (MGI Ref ID J:47907)

Ts(16C-tel)1Cje/0

        involves: C3H/HeJ * C57BL/6 * Rb(16.17)32Lub * STOCK Rb(11.16)2H/H
  • craniofacial phenotype
  • abnormal mandibular angle morphology
    • reduced in size compared to in wild-type mice   (MGI Ref ID J:73800)
  • abnormal mandibular coronoid process morphology
    • reduced in size compared to in wild-type mice   (MGI Ref ID J:73800)
  • abnormal molar morphology
    • the distance between the most anterior and most posterior points on the molar alveolar is smaller than in wild-type mice   (MGI Ref ID J:73800)
  • abnormal neurocranium morphology
    • the cranial vault is reduced by 4%   (MGI Ref ID J:73800)
  • decreased cranium height
    • the cranium is reduced along the anteriorposterior axis compared to in wild-type mice   (MGI Ref ID J:73800)
  • shortened head   (MGI Ref ID J:73800)
  • small mandible   (MGI Ref ID J:73800)
  • nervous system phenotype
  • *normal* nervous system phenotype
    • despite reductions in granule cell density and cerebellar size, Purkinje cell density is normal   (MGI Ref ID J:91221)
    • abnormal cerebellar granule cell morphology
      • granule cell density is reduced to 76% of normal   (MGI Ref ID J:91221)
    • small cerebellum
      • cerebellar volume is decreased to 88.8% of normal   (MGI Ref ID J:91221)
      • cerebellar area is decreased to 86.3% of normal   (MGI Ref ID J:91221)
  • skeleton phenotype
  • abnormal mandibular angle morphology
    • reduced in size compared to in wild-type mice   (MGI Ref ID J:73800)
  • abnormal mandibular coronoid process morphology
    • reduced in size compared to in wild-type mice   (MGI Ref ID J:73800)
  • abnormal neurocranium morphology
    • the cranial vault is reduced by 4%   (MGI Ref ID J:73800)
  • decreased cranium height
    • the cranium is reduced along the anteriorposterior axis compared to in wild-type mice   (MGI Ref ID J:73800)
  • small mandible   (MGI Ref ID J:73800)
  • growth/size/body phenotype
  • abnormal molar morphology
    • the distance between the most anterior and most posterior points on the molar alveolar is smaller than in wild-type mice   (MGI Ref ID J:73800)
  • shortened head   (MGI Ref ID J:73800)

Ts(16C-tel)1Cje/0

        involves: C57BL/6J * Rb(11.16)2H * Rb(16.17)32Lub
  • tumorigenesis
  • increased lymphoma incidence
    • malignant lymphoma in the spleen and lymph nodes is observed in some mutants   (MGI Ref ID J:174270)
    • megakaryocytes are numerous is some spleens, suggesting a relation to megakaryocytic leukemia   (MGI Ref ID J:174270)
    • increased follicular lymphoma incidence
      • splenic architecture is replaced by proliferated immature mononuclear cells arranged in follicular aggregates indicating follicular lymphoma   (MGI Ref ID J:174270)
  • immune system phenotype
  • abnormal spleen B cell follicle morphology
    • splenic white pulp contains follicles that are larger and more irregular in shape than normal follicles and are often fused with adjacent follicles   (MGI Ref ID J:174270)
  • abnormal spleen red pulp morphology
    • splenic red pulp is largely obliterated   (MGI Ref ID J:174270)
  • hematopoietic system phenotype
  • abnormal spleen B cell follicle morphology
    • splenic white pulp contains follicles that are larger and more irregular in shape than normal follicles and are often fused with adjacent follicles   (MGI Ref ID J:174270)
  • abnormal spleen red pulp morphology
    • splenic red pulp is largely obliterated   (MGI Ref ID J:174270)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Neurobiology Research
Down syndrome

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Ts(16C-tel)1Cje
Allele Name trisomy, (16C-tel), 1 Charles J Epstein
Allele Type Spontaneous
Common Name(s) Ts(1216)1Cje; Ts108Cje; Ts1Cje; partial trisomy 16;
Strain of OriginC57BL/6J x (Rb(11.16)2H x Rb(16.17)32Lub)F1
ES Cell Line NameCB1-4
ES Cell Line StrainC57BL/6J x (Rb(11.16)2H x Rb(16.17)32Lub)F1
Gene Symbol and Name Ts(16C-tel)1Cje, trisomy, (16C-tel), 1 Charles J Epstein
Chromosome 16
Gene Common Name(s) Ts(1216)1Cje; Ts108Cje; Ts1Cje; partial trisomy 16; trisomy,Chr 12 translocation to Chr 16, Charles J Epstein;
Molecular Note This chromosomal trisomy comprises two normal Chr 16s and the reciprocal translocation product 1216. Mice are trisomic for the cytogenetic interval 16C-tel and the genetic interval Sod1 to Mx1. Sod1 is not functionally trisomic because the Sod1 gene in the translocated segment is inactivated by the insertion of the neomycin resistance sequence. The Ts1Cje mouse model ofDown syndrome is trisomic for 94 genes on Mmu16, covering approximately two-thirds of the trisomic region in Ts65Dn mice. [MGI Ref ID J:160790] [MGI Ref ID J:47907]

Genotyping

Genotyping Information

Genotyping Protocols

Generic Pde6b, High Resolution Melting
Generic Neo Quantitative PCR-QPCR- 1.2, QPCR
Generic Pde6b, Standard PCR
NEOTD (Generic Neo), Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Sago H; Carlson EJ; Smith DJ; Kilbridge J; Rubin EM; Mobley WC; Epstein CJ; Huang TT. 1998. Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities. Proc Natl Acad Sci U S A 95(11):6256-61. [PubMed: 9600952]  [MGI Ref ID J:47907]

Additional References

Davisson M; Akeson E; Schmidt C; Harris B; Farley J; Handel MA. 2007. Impact of trisomy on fertility and meiosis in male mice. Hum Reprod 22(2):468-76. [PubMed: 17050550]  [MGI Ref ID J:117029]

Huang TT; Yasunami M; Carlson EJ; Gillespie AM; Reaume AG; Hoffman EK ; Chan PH ; Scott RW ; Epstein CJ. 1997. Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch Biochem Biophys 344(2):424-32. [PubMed: 9264557]  [MGI Ref ID J:42265]

Richtsmeier JT; Zumwalt A; Carlson EJ; Epstein CJ; Reeves RH. 2002. Craniofacial phenotypes in segmentally trisomic mouse models for Down syndrome. Am J Med Genet 107(4):317-24. [PubMed: 11840489]  [MGI Ref ID J:73800]

Ts(16C-tel)1Cje related

Adorno M; Sikandar S; Mitra SS; Kuo A; Nicolis Di Robilant B; Haro-Acosta V; Ouadah Y; Quarta M; Rodriguez J; Qian D; Reddy VM; Cheshier S; Garner CC; Clarke MF. 2013. Usp16 contributes to somatic stem-cell defects in Down's syndrome. Nature 501(7467):380-4. [PubMed: 24025767]  [MGI Ref ID J:206099]

Alford KA; Slender A; Vanes L; Li Z; Fisher EM; Nizetic D; Orkin SH; Roberts I; Tybulewicz VL. 2010. Perturbed hematopoiesis in the Tc1 mouse model of Down syndrome. Blood 115(14):2928-37. [PubMed: 20154221]  [MGI Ref ID J:160790]

Alves-Sampaio A; Troca-Marin JA; Montesinos ML. 2010. NMDA-mediated regulation of DSCAM dendritic local translation is lost in a mouse model of Down's syndrome. J Neurosci 30(40):13537-48. [PubMed: 20926679]  [MGI Ref ID J:165095]

Amano K; Sago H; Uchikawa C; Suzuki T; Kotliarova SE; Nukina N; Epstein CJ; Yamakawa K. 2004. Dosage-dependent over-expression of genes in the trisomic region of Ts1Cje mouse model for Down syndrome. Hum Mol Genet 13(13):1333-40. [PubMed: 15138197]  [MGI Ref ID J:91249]

Belichenko PV; Kleschevnikov AM; Salehi A; Epstein CJ; Mobley WC. 2007. Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships. J Comp Neurol 504(4):329-45. [PubMed: 17663443]  [MGI Ref ID J:132525]

Bhutta MF; Cheeseman MT; Herault Y; Yu YE; Brown SD. 2013. Surveying the Down syndrome mouse model resource identifies critical regions responsible for chronic otitis media. Mamm Genome :. [PubMed: 24068166]  [MGI Ref ID J:201811]

Canzonetta C; Mulligan C; Deutsch S; Ruf S; O'Doherty A; Lyle R; Borel C; Lin-Marq N; Delom F; Groet J; Schnappauf F; De Vita S; Averill S; Priestley JV; Martin JE; Shipley J; Denyer G; Epstein CJ; Fillat C; Estivill X; Tybulewicz VL; Fisher EM; Antonarakis SE; Nizetic D. 2008. DYRK1A-dosage imbalance perturbs NRSF/REST levels, deregulating pluripotency and embryonic stem cell fate in Down syndrome. Am J Hum Genet 83(3):388-400. [PubMed: 18771760]  [MGI Ref ID J:140118]

Carmichael CL; Majewski IJ; Alexander WS; Metcalf D; Hilton DJ; Hewitt CA; Scott HS. 2009. Hematopoietic defects in the Ts1Cje mouse model of Down syndrome. Blood 113(9):1929-37. [PubMed: 19109561]  [MGI Ref ID J:145995]

Colas D; Valletta JS; Takimoto-Kimura R; Nishino S; Fujiki N; Mobley WC; Mignot E. 2008. Sleep and EEG features in genetic models of Down syndrome. Neurobiol Dis 30(1):1-7. [PubMed: 18282758]  [MGI Ref ID J:136520]

Davisson M; Akeson E; Schmidt C; Harris B; Farley J; Handel MA. 2007. Impact of trisomy on fertility and meiosis in male mice. Hum Reprod 22(2):468-76. [PubMed: 17050550]  [MGI Ref ID J:117029]

Duchon A; Raveau M; Chevalier C; Nalesso V; Sharp AJ; Herault Y. 2011. Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling down syndrome. Mamm Genome 22(11-12):674-84. [PubMed: 21953411]  [MGI Ref ID J:178872]

Hewitt CA; Ling KH; Merson TD; Simpson KM; Ritchie ME; King SL; Pritchard MA; Smyth GK; Thomas T; Scott HS; Voss AK. 2010. Gene network disruptions and neurogenesis defects in the adult Ts1Cje mouse model of Down syndrome. PLoS One 5(7):e11561. [PubMed: 20661276]  [MGI Ref ID J:163093]

Huang TT; Yasunami M; Carlson EJ; Gillespie AM; Reaume AG; Hoffman EK ; Chan PH ; Scott RW ; Epstein CJ. 1997. Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch Biochem Biophys 344(2):424-32. [PubMed: 9264557]  [MGI Ref ID J:42265]

Ishihara K; Amano K; Takaki E; Ebrahim AS; Shimohata A; Shibazaki N; Inoue I; Takaki M; Ueda Y; Sago H; Epstein CJ; Yamakawa K. 2009. Increased lipid peroxidation in Down's syndrome mouse models. J Neurochem 110(6):1965-76. [PubMed: 19645748]  [MGI Ref ID J:152486]

Ishihara K; Amano K; Takaki E; Shimohata A; Sago H; Epstein CJ; Yamakawa K. 2010. Enlarged brain ventricles and impaired neurogenesis in the Ts1Cje and Ts2Cje mouse models of Down syndrome. Cereb Cortex 20(5):1131-43. [PubMed: 19710359]  [MGI Ref ID J:174165]

Klusmann JH; Godinho FJ; Heitmann K; Maroz A; Koch ML; Reinhardt D; Orkin SH; Li Z. 2010. Developmental stage-specific interplay of GATA1 and IGF signaling in fetal megakaryopoiesis and leukemogenesis. Genes Dev 24(15):1659-72. [PubMed: 20679399]  [MGI Ref ID J:163249]

Kurabayashi N; Sanada K. 2013. Increased dosage of DYRK1A and DSCR1 delays neuronal differentiation in neocortical progenitor cells. Genes Dev 27(24):2708-21. [PubMed: 24352425]  [MGI Ref ID J:205486]

Laffaire J; Rivals I; Dauphinot L; Pasteau F; Wehrle R; Larrat B; Vitalis T; Moldrich RX; Rossier J; Sinkus R; Herault Y; Dusart I; Potier MC. 2009. Gene expression signature of cerebellar hypoplasia in a mouse model of Down syndrome during postnatal development. BMC Genomics 10:138. [PubMed: 19331679]  [MGI Ref ID J:148509]

Levine S; Saltzman A; Levy E; Ginsberg SD. 2009. Systemic pathology in aged mouse models of Down's syndrome and Alzheimer's disease. Exp Mol Pathol 86(1):18-22. [PubMed: 19041304]  [MGI Ref ID J:174270]

Mouton-Liger F; Thomas S; Rattenbach R; Magnol L; Larigaldie V; Ledru A; Herault Y; Verney C; Creau N. 2011. PCP4 (PEP19) overexpression induces premature neuronal differentiation associated with Ca(2+) /Calmodulin-Dependent kinase II-delta activation in mouse models of down syndrome. J Comp Neurol 519(14):2779-802. [PubMed: 21491429]  [MGI Ref ID J:174150]

Olson LE; Roper RJ; Baxter LL; Carlson EJ; Epstein CJ; Reeves RH. 2004. Down syndrome mouse models Ts65Dn, Ts1Cje, and Ms1Cje/Ts65Dn exhibit variable severity of cerebellar phenotypes. Dev Dyn 230(3):581-9. [PubMed: 15188443]  [MGI Ref ID J:91221]

Potier MC; Rivals I; Mercier G; Ettwiller L; Moldrich RX; Laffaire J; Personnaz L; Rossier J; Dauphinot L. 2006. Transcriptional disruptions in Down syndrome: a case study in the Ts1Cje mouse cerebellum during post-natal development. J Neurochem 97 Suppl 1:104-9. [PubMed: 16635258]  [MGI Ref ID J:144411]

Rachidi M; Lopes C. 2007. Mental retardation in Down syndrome: from gene dosage imbalance to molecular and cellular mechanisms. Neurosci Res 59(4):349-69. [PubMed: 17897742]  [MGI Ref ID J:128743]

Richtsmeier JT; Zumwalt A; Carlson EJ; Epstein CJ; Reeves RH. 2002. Craniofacial phenotypes in segmentally trisomic mouse models for Down syndrome. Am J Med Genet 107(4):317-24. [PubMed: 11840489]  [MGI Ref ID J:73800]

Sago H; Carlson EJ; Smith DJ; Rubin EM; Crnic LS; Huang TT; Epstein CJ. 2000. Genetic dissection of region associated with behavioral abnormalities in mouse models for Down syndrome. Pediatr Res 48(5):606-13. [PubMed: 11044479]  [MGI Ref ID J:86822]

Salehi A; Delcroix JD; Belichenko PV; Zhan K; Wu C; Valletta JS; Takimoto-Kimura R; Kleschevnikov AM; Sambamurti K; Chung PP; Xia W; Villar A; Campbell WA; Kulnane LS; Nixon RA; Lamb BT; Epstein CJ; Stokin GB; Goldstein LS; Mobley WC. 2006. Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron 51(1):29-42. [PubMed: 16815330]  [MGI Ref ID J:122937]

Salehi A; Faizi M; Colas D; Valletta J; Laguna J; Takimoto-Kimura R; Kleschevnikov A; Wagner SL; Aisen P; Shamloo M; Mobley WC. 2009. Restoration of norepinephrine-modulated contextual memory in a mouse model of Down syndrome. Sci Transl Med 1(7):7ra17. [PubMed: 20368182]  [MGI Ref ID J:167886]

Shukkur EA; Shimohata A; Akagi T; Yu W; Yamaguchi M; Murayama M; Chui D; Takeuchi T; Amano K; Subramhanya KH; Hashikawa T; Sago H; Epstein CJ; Takashima A; Yamakawa K. 2006. Mitochondrial dysfunction and tau hyperphosphorylation in Ts1Cje, a mouse model for Down syndrome. Hum Mol Genet 15(18):2752-62. [PubMed: 16891409]  [MGI Ref ID J:114926]

Siarey RJ; Villar AJ; Epstein CJ; Galdzicki Z. 2005. Abnormal synaptic plasticity in the Ts1Cje segmental trisomy 16 mouse model of Down syndrome. Neuropharmacology 49(1):122-8. [PubMed: 15992587]  [MGI Ref ID J:106375]

Siddiqui A; Lacroix T; Stasko MR; Scott-McKean JJ; Costa AC; Gardiner KJ. 2008. Molecular responses of the Ts65Dn and Ts1Cje mouse models of Down syndrome to MK-801. Genes Brain Behav 7(7):810-20. [PubMed: 19125866]  [MGI Ref ID J:151137]

Vialard F; Toyama K; Vernoux S; Carlson EJ; Epstein CJ; Sinet PM; Rahmani Z. 2000. Overexpression of mSim2 gene in the zona limitans of the diencephalon of segmental trisomy 16 Ts1Cje fetuses, a mouse model for trisomy 21: a novel whole-mount based RNA hybridization study. Brain Res Dev Brain Res 121(1):73-8. [PubMed: 10837894]  [MGI Ref ID J:62599]

Villar AJ; Belichenko PV; Gillespie AM; Kozy HM; Mobley WC; Epstein CJ. 2005. Identification and characterization of a new Down syndrome model, Ts[Rb(12.1716)]2Cje, resulting from a spontaneous Robertsonian fusion between T(171)65Dn and mouse chromosome 12. Mamm Genome 16(2):79-90. [PubMed: 15859352]  [MGI Ref ID J:96650]

Wiseman FK; Alford KA; Tybulewicz VL; Fisher EM. 2009. Down syndrome--recent progress and future prospects. Hum Mol Genet 18(R1):R75-83. [PubMed: 19297404]  [MGI Ref ID J:156661]

Xu JC; Dawson VL; Dawson TM. 2013. Usp16: key controller of stem cells in Down syndrome. EMBO J 32(21):2788-9. [PubMed: 24076652]  [MGI Ref ID J:202008]

Zhang L; Fu D; Belichenko PV; Liu C; Kleschevnikov AM; Pao A; Liang P; Clapcote SJ; Mobley WC; Yu YE. 2012. Genetic analysis of Down syndrome facilitated by mouse chromosome engineering. Bioeng Bugs 3(1):8-12. [PubMed: 22126738]  [MGI Ref ID J:196862]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2525.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3283.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

General Supply Notes

Control Information

  Control
   Wild-type littermate
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Important Note

Pde6brd1, the recessive retinal degeneration 1 mutation, is segregating in this colony. Animals that are homozygous for rd1 will be blind.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Strain from the Cytogenetic Models Resource. First time use requires submission of a Request Form, please inquire.

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phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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