Strain Name: |
B6EiC3Sn-Ts(16C-tel)1Cje |
|---|---|
Stock Number: |
004861 |
Availability: | Repository-Cryopreserved |
Price and Supply Information | |
General Terms and Conditions |
| Former Name |
B6EiC3Sn-Ts(1216C-tel)1Cje (Changed: 17-FEB-05
) |
|
B6Ei;C3Sn-Ts(1216C-tel)1Cje (Changed: 15-DEC-04
) | |
| Genes & Alleles | T(12;16)1Cje; ; |
Product Information
Strain Details
Type Chromosome Aberration Additional information on Mice with Chromosomal Aberrations. Type JAX® GEMM® Strain - Mutant Stock Additional information on JAX® GEMM® Strains. Type Translocation Additional information on Mice with Chromosomal Aberrations. Type Trisomy Additional information on Mice with Chromosomal Aberrations. Species laboratory mouse Important Note
Pde6brd1, the recessive retinal degeneration 1 mutation, is segregating in this colony. Animals that are homozygous for rd1 will be blind.Strain Description
Ts(16C-tel)1Cje trisomic mice display decreased exploratory behavior and have spatial learning deficits detectable in the hidden platform and probe versions of the Morris water maze. These learning deficits are less severe than those of mice carrying Ts(1716)Dn, a larger distal chromosome 16 translocation. The degeneration of basal forebrain cholinergic neurons that is found in Ts(1716)Dn carriers has not been found by six months of age in mice carrying Ts(16C-tel)1Cje. Additionally, the male sterility found in Ts(1716)Dn carriers is not a phenotype associated with Ts(16C-tel)1Cje. (Sago et al., 1998.) Despite having fewer trisomic genes, Ts(16C-tel)1Cje carriers display much of the same craniofacial dysmorphology as that found in Ts(1716)Dn, which includes brachycephaly, reduced interorbital breadth, and smaller mandible. (Richtsmeier et al., 2002.)Strain Development
The Ts(16C-tel)1Cje mutation was identified during the screening that followed the tm1Cje targeted mutation of Sod1. This targeted disruption was done in CB1-4 ES cells which were derived from the embryos of a C57BL/6 female bred to an (Rb(11.16)2H x Rb(16.17)32Lub) F1 male, and the founders were backcrossed to CD1 for several generations. In these progeny a sub-population of mice was found that carried the neomycin resistance gene indicative of the targeted disruption of Sod1 but had normal levels of copper-zinc superoxide dismutase activity. FISH analysis revealed an Sod1tm1Cje-bearing translocation of distal chromosome 16 onto chromosome 12, which has been named Ts(16C-tel)1Cje. By breeding to wildtype mice, a partial trisomy line was generated with two wildtype chromosomes 16 and the additional copy of distal chromosome 16 translocated onto one chromosome 12. This was backcrossed onto C57BL/6J and in 1997 Dr Charlie Epstein sent N10 carriers to The Jackson Laboratory where they were backcrossed to C57BL/6J for several generations. However, the viability on the inbred background proved difficult. It is now bred to B6EiC3SnF1/J A/a at each generation.
Gene & Allele Details
| Gene Symbol and Name | T(12;16)1Cje, reciprocal translocation, Chr 12 and 16, Epstein 1 | ||
|---|---|---|---|
| Chromosome | 16 | ||
| Gene Symbol and Name | T(12;16)1Cje, reciprocal translocation, Chr 12 and 16, Epstein 1 | ||
| Chromosome | 12 | ||
Control Information
| Control | ||
|---|---|---|
| Wild-type littermate | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for JAX® GEMM® Strains | ||
Genotyping Protocols
NEOTD (Generic Neo)
Related Strains
Trisomies
001924 B6EiC3Sn a/A-Ts(1716)65Dn 001923 B6EiC3Sn a/A-Ts(417)2Lws Tim/J View Trisomies (2 strains)
Research Applications
This mouse can be used to support research in many areas including:
Mouse/Human Gene Homologs
Down syndrome
Neurobiology Research
Behavioral and Learning Defects (Down syndrome)
References
Selected Reference(s)
Additional ReferencesSago H; Carlson EJ; Smith DJ; Kilbridge J; Rubin EM; Mobley WC; Epstein CJ; Huang TT. 1998. Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities. Proc Natl Acad Sci U S A 95(11):6256-61. [PubMed: 9600952] [MGI Ref ID J:47907]
Price and Supply Information
| Strain Name: | B6EiC3Sn-Ts(16C-tel)1Cje |
| Stock Number: | 004861 |
Price Details
IMPORTANT NOTE: Prices are based on shipping destination. The shipping destinations are:
- USA, Canada and Mexico
- International
*Pricing for Shipping Destination selected:
USA, Canada and Mexico
| Price(s) in US dollars ($) | |||||
|---|---|---|---|---|---|
| Cryorecovery Fee | $1900.00 | ||||
Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to the Supply Notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Request Form |
Strain from the Cytogenetic Models Resource. First time use requires submission of a Request Form, please inquire. |
| Licensing | See General Terms and Conditions below |
| Control Information | View Control Information in Strain Details. View Control Pricing Information for JAX® Strains. |
General Terms and Conditions
View JAX® Mice & Services Conditions of Use.
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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