Strain Name:

B6.Cg-Fcgrttm1Dcr Tg(CAG-FCGRT)276Dcr/DcrJ

Stock Number:

004919

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Availability:

Repository- Live

Use Restrictions Apply, see Terms of Use
Common Names: FcRn<-/-> hFcRn (276) Tg;    
FcRn-/- hFcRn (line 276) Tg mice are useful in evaluating the pharmacokinetics and pharmacodynamics of human immunoglobulin G (hIgG), such as therapeutic IgG. These mice carry a null mutation for the mouse gene and a transgene expressing the human FcRn α-chain under the control of the ubiquitous CAG promoter.

Description

Strain Information

Former Names B6.Cg-Fcgrttm1Dcr Tg(FCGRT)276Dcr    (Changed: 15-APR-10 )
Type Congenic; Mutant Strain; Targeted Mutation; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Mating SystemSee Colony Maintenance under the Health & Care tab         (Female x Male)   21-SEP-10
Specieslaboratory mouse
GenerationN11F13p+F12 (12-DEC-13)
Generation Definitions
 
Donating InvestigatorDr. Derry Roopenian,   The Jackson Laboratory

Description
FcRn-/- hFcRn (276) Tg mice harbor a knockout allele of the FcRn α-chain (Fcgrttm1Dcr) and express the human FcRn α-chain cDNA (FCGRT) under the control the human cytomegalovirus immediate early promoter/enhancer with chicken beta-actin/rabbit beta-globin hybrid promoter (CAG). FcRn-/- mice (see Stock No. 003982) lack murine FcRn α-chain expression and fail to transport IgG across the neonatal gut; they do not recycle IgG and albumin and therefore show low plasma levels of both. In FcRn-/- hFcRn (276) Tg mice, plasma albumin levels are similar to wild-type mice, however the serum IgG levels remain low due to the species-specific behavior of human FcRn. A number of studies have shown this model's usefulness for pharmacokinetic and pharmacodynamic studies of human IgG and to screen hIgGs, with regard to their serum half-life. For example, human antibodies engineered to have enhanced binding to human FcRn (Hu4D5-IgG1, directed against human EGFR2) exhibit a significant increase in their serum half-life (2-2.5 fold) in these mice. Specifically, longer half-lives are observed in this strain with mice homozygous for the hFcRn transgene (hFcRn Tg/Tg) when compared to mice hemizygous for the hFcRn transgene (hFcRn Tg/0), indicating that higher copy number correlates with higher expression of FCGRT and provides greater protection of IgG from clearance. This mouse model is useful for studying human FcRn biology and the behavior of IgG antibodies and Fc-domain proteins, including Fc-engineered molecules.

Development
FcRn α-chain knockout mice expressing a human FcRn transgene (line 276) are also called FcRn-/- hFcRn (276) Tg mice, cDNA transgenic line 276, mFcRn-/- hFcRn (276) Tg [carrying one allele of the transgene], or mFcRn-/- hFcRn (276) Tg/Tg [carrying two alleles of the transgene]. These FcRn-/- hFcRn (276) Tg mice were generated in the laboratory of Derry Roopenian (The Jackson Laboratory) by crossing Fcgrttm1Dcr targeted mutant mice (backcrossed five generations to C57BL/6J) with Tg(CAG-FCGRT)276Dcr transgenic mice (coisogenic on a C57BL/6J genetic background). These double mutant mice were backcrossed for several additional generations to C57BL/6J (~N11) prior to transfer to The Jackson Laboratory Repository.

To generate the FcRn α-chain knockout mice (Fcgrttm1Dcr; see also Stock No. 003982), a targeting vector was designed to replace 1588 nucleotide fragments (encoding promoter sequence 5' of the transcriptional start site, exon1, intron 2, and most of exon2) with a PGK-Neor cassette. The vector was electroporated into 129X1/SvJ-derived ESV/J-1182 embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts. The resulting chimeric animals were crossed to C57BL/6J mice. These FcRn α-chain mutant mice were backcrossed to C57BL/6J for five generations prior to breeding with hFcRn line 276 transgenic mice.

To generate the hFcRn line 276 transgenic mice, a transgene was designed with the 0.34 kb human cytomegalovirus immediate early promoter enhancer, 1.4 kb chicken beta-actin promoter and intron 1, a cDNA sequence encoding the human FcRn α-chain, 0.73 kb rabbit beta-globin intron, and 0.35 kb SV40 polyA sequence. The donating investigator reports that this transgene was injected into C57BL/6J embryos. The resulting transgenic offspring were bred to C57BL/6J mice to establish founder line 276. These hFcRn line 276 transgenic mice were maintained on a C57BL/6J genetic background.

Control Information

  Control
   See control note: Stock No. 003982 is an appropriate experimental control as well.
   000664 C57BL/6J
 
  Considerations for Choosing Controls

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Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Fcgrttm1Dcr/Fcgrttm1Dcr Tg(CAG-FCGRT)276Dcr/0

        involves: 129X1/SvJ * C57BL/6 * C57BL/6J
  • homeostasis/metabolism phenotype
  • increased circulating serum albumin level   (MGI Ref ID J:110885)
  • immune system phenotype
  • *normal* immune system phenotype
    • IgG levels are normalized   (MGI Ref ID J:110885)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Immunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
      genes regulating susceptibility to infectious disease and endotoxin
Immunodeficiency
      MHC class I deficiency
      defects in humoral immune responses

Research Tools
Immunology, Inflammation and Autoimmunity Research
      MHC class I deficiency

Virology Research
Reduced MHC Class I Responses to Specific Viruses

Fcgrttm1Dcr related

Immunology, Inflammation and Autoimmunity Research
Autoimmunity
CD Antigens, Antigen Receptors, and Histocompatibility Markers
      genes regulating susceptibility to infectious disease and endotoxin
Immunodeficiency
      defects in humoral immune responses

Research Tools
Immunology, Inflammation and Autoimmunity Research
      genes regulating susceptibility to infectious disease and endotoxin

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Fcgrttm1Dcr
Allele Name targeted mutation 1, Derry C Roopenian
Allele Type Targeted (Null/Knockout)
Common Name(s) FcRn-;
Strain of Origin129X1/SvJ
ES Cell Line NameRW-4
ES Cell Line Strain129X1/SvJ
Gene Symbol and Name Fcgrt, Fc receptor, IgG, alpha chain transporter
Chromosome 7
Gene Common Name(s) FCRN; alpha-chain; neonatal Fc receptor;
Molecular Note Sequence from exon 1 and part of exon2 was replaced with a PGK-neo cassette. Quantitative PCR of liver cDNA indicated the absence of mRNA. Western blot analysis of neonatal intestinal extracts failed to reveal protein product. [MGI Ref ID J:94189]
 
Allele Symbol Tg(CAG-FCGRT)276Dcr
Allele Name transgene insertion 276, Derry C Roopenian
Allele Type Transgenic (Inserted expressed sequence)
Common Name(s) Tg276; hFcRn (276) Tg;
Strain of OriginC57BL/6J
Expressed Gene FCGRT, Fc fragment of IgG, receptor, transporter, alpha, human
Promoter ACTB, actin, beta, chicken
Molecular Note To generate the hFcRn line 276 transgenic mice, a transgene was designed with the 0.34 kb human cytomegalovirus immediate early promoter enhancer, 1.4 kb chicken beta-actin promoter and intron 1, a cDNA sequence encoding the human FcRn alpha-chain, 0.73 kb rabbit beta-globin intron, and 0.35 kb SV40 polyA sequence. Line 276 was established. [MGI Ref ID J:110885]
 
 

Genotyping

Genotyping Information

Genotyping Protocols

Prkdcscid End Point, End Point Analysis
Tg(FCGRT), QPCR
Fcgrttm1Dcr, Standard PCR
Tg(FCGRT), Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Chaudhury C; Mehnaz S; Robinson JM; Hayton WL; Pearl DK; Roopenian DC; Anderson CL. 2003. The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan. J Exp Med 197(3):315-22. [PubMed: 12566415]  [MGI Ref ID J:110885]

Petkova SB; Akilesh S; Sproule TJ; Christianson GJ; Al Khabbaz H; Brown AC; Presta LG; Meng YG; Roopenian DC. 2006. Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease. Int Immunol 18(12):1759-69. [PubMed: 17077181]  [MGI Ref ID J:133048]

Roopenian DC; Christianson GJ; Sproule TJ; Brown AC; Akilesh S; Jung N; Petkova S; Avanessian L; Choi EY; Shaffer DJ; Eden PA; Anderson CL. 2003. The MHC class I-like IgG receptor controls perinatal IgG transport, IgG homeostasis, and fate of IgG-Fc-coupled drugs. J Immunol 170(7):3528-33. [PubMed: 12646614]  [MGI Ref ID J:94189]

Wang W; Vlasak J; Li Y; Pristatsky P; Fang Y; Pittman T; Roman J; Wang Y; Prueksaritanont T; Ionescu R. 2011. Impact of methionine oxidation in human IgG1 Fc on serum half-life of monoclonal antibodies. Mol Immunol 48(6-7):860-6. [PubMed: 21256596]  [MGI Ref ID J:170957]

Zalevsky J; Chamberlain AK; Horton HM; Karki S; Leung IW; Sproule TJ; Lazar GA; Roopenian DC; Desjarlais JR. 2010. Enhanced antibody half-life improves in vivo activity. Nat Biotechnol 28(2):157-9. [PubMed: 20081867]  [MGI Ref ID J:161273]

Additional References

Roopenian DC; Akilesh S. 2007. FcRn: the neonatal Fc receptor comes of age. Nat Rev Immunol 7(9):715-25. [PubMed: 17703228]  [MGI Ref ID J:161274]

Fcgrttm1Dcr related

Akilesh S; Christianson GJ; Roopenian DC; Shaw AS. 2007. Neonatal FcR expression in bone marrow-derived cells functions to protect serum IgG from catabolism. J Immunol 179(7):4580-8. [PubMed: 17878355]  [MGI Ref ID J:152349]

Akilesh S; Huber TB; Wu H; Wang G; Hartleben B; Kopp JB; Miner JH; Roopenian DC; Unanue ER; Shaw AS. 2008. Podocytes use FcRn to clear IgG from the glomerular basement membrane. Proc Natl Acad Sci U S A 105(3):967-72. [PubMed: 18198272]  [MGI Ref ID J:131366]

Akilesh S; Petkova S; Sproule TJ; Shaffer DJ; Christianson GJ; Roopenian D. 2004. The MHC class I-like Fc receptor promotes humorally mediated autoimmune disease. J Clin Invest 113(9):1328-33. [PubMed: 15124024]  [MGI Ref ID J:95104]

Andersen JT; Foss S; Kenanova VE; Olafsen T; Leikfoss IS; Roopenian DC; Wu AM; Sandlie I. 2012. Anti-carcinoembryonic antigen single-chain variable fragment antibody variants bind mouse and human neonatal Fc receptor with different affinities that reveal distinct cross-species differences in serum half-life. J Biol Chem 287(27):22927-37. [PubMed: 22570488]  [MGI Ref ID J:188378]

Bai Y; Ye L; Tesar DB; Song H; Zhao D; Bjorkman PJ; Roopenian DC; Zhu X. 2011. Intracellular neutralization of viral infection in polarized epithelial cells by neonatal Fc receptor (FcRn)-mediated IgG transport. Proc Natl Acad Sci U S A 108(45):18406-11. [PubMed: 22042859]  [MGI Ref ID J:180229]

Baker K; Qiao SW; Kuo TT; Aveson VG; Platzer B; Andersen JT; Sandlie I; Chen Z; de Haar C; Lencer WI; Fiebiger E; Blumberg RS. 2011. Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells. Proc Natl Acad Sci U S A 108(24):9927-32. [PubMed: 21628593]  [MGI Ref ID J:173310]

Baker K; Rath T; Flak MB; Arthur JC; Chen Z; Glickman JN; Zlobec I; Karamitopoulou E; Stachler MD; Odze RD; Lencer WI; Jobin C; Blumberg RS. 2013. Neonatal Fc receptor expression in dendritic cells mediates protective immunity against colorectal cancer. Immunity 39(6):1095-107. [PubMed: 24290911]  [MGI Ref ID J:209206]

Binstadt BA; Patel PR; Alencar H; Nigrovic PA; Lee DM; Mahmood U; Weissleder R; Mathis D; Benoist C. 2006. Particularities of the vasculature can promote the organ specificity of autoimmune attack. Nat Immunol 7(3):284-92. [PubMed: 16444258]  [MGI Ref ID J:112604]

Chaudhury C; Kim J; Mehnaz S; Wani MA; Oberyszyn TM; Bronson CL; Mohanty S; Hayton WL; Robinson JM; Anderson CL. 2006. Accelerated transferrin degradation in HFE-deficient mice is associated with increased transferrin saturation. J Nutr 136(12):2993-8. [PubMed: 17116709]  [MGI Ref ID J:117735]

Chen P; Li C; Lang S; Zhu G; Reheman A; Spring CM; Freedman J; Ni H. 2010. Animal model of fetal and neonatal immune thrombocytopenia: role of neonatal Fc receptor in the pathogenesis and therapy. Blood 116(18):3660-8. [PubMed: 20647570]  [MGI Ref ID J:166478]

Crow AR; Suppa SJ; Chen X; Mott PJ; Lazarus AH. 2011. The neonatal Fc receptor (FcRn) is not required for IVIg or anti-CD44 monoclonal antibody-mediated amelioration of murine immune thrombocytopenia. Blood 118(24):6403-6. [PubMed: 22001393]  [MGI Ref ID J:179078]

Crowley H; Alroy J; Sproule TJ; Roopenian D; Huber BT. 2006. The MHC class I-related FcRn ameliorates murine Lyme arthritis. Int Immunol 18(3):409-14. [PubMed: 16415101]  [MGI Ref ID J:106617]

Deane R; Sagare A; Hamm K; Parisi M; LaRue B; Guo H; Wu Z; Holtzman DM; Zlokovic BV. 2005. IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor. J Neurosci 25(50):11495-503. [PubMed: 16354907]  [MGI Ref ID J:103998]

Dumont JA; Liu T; Low SC; Zhang X; Kamphaus G; Sakorafas P; Fraley C; Drager D; Reidy T; McCue J; Franck HW; Merricks EP; Nichols TC; Bitonti AJ; Pierce GF; Jiang H. 2012. Prolonged activity of a recombinant factor VIII-Fc fusion protein in hemophilia A mice and dogs. Blood 119(13):3024-30. [PubMed: 22246033]  [MGI Ref ID J:182551]

Kim J; Bronson CL; Hayton WL; Radmacher MD; Roopenian DC; Robinson JM; Anderson CL. 2006. Albumin turnover: FcRn-mediated recycling saves as much albumin from degradation as the liver produces. Am J Physiol Gastrointest Liver Physiol 290(2):G352-60. [PubMed: 16210471]  [MGI Ref ID J:106048]

Kim J; Mohanty S; Ganesan LP; Hua K; Jarjoura D; Hayton WL; Robinson JM; Anderson CL. 2009. FcRn in the yolk sac endoderm of mouse is required for IgG transport to fetus. J Immunol 182(5):2583-9. [PubMed: 19234152]  [MGI Ref ID J:146267]

Koltun M; Nikolovski J; Strong K; Nikolic-Paterson D; Comper WD. 2005. Mechanism of hypoalbuminemia in rodents. Am J Physiol Heart Circ Physiol 288(4):H1604-10. [PubMed: 15539420]  [MGI Ref ID J:97362]

Letourneau S; van Leeuwen EM; Krieg C; Martin C; Pantaleo G; Sprent J; Surh CD; Boyman O. 2010. IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor alpha subunit CD25. Proc Natl Acad Sci U S A 107(5):2171-6. [PubMed: 20133862]  [MGI Ref ID J:157531]

Li N; Zhao M; Hilario-Vargas J; Prisayanh P; Warren S; Diaz LA; Roopenian DC; Liu Z. 2005. Complete FcRn dependence for intravenous Ig therapy in autoimmune skin blistering diseases. J Clin Invest 115(12):3440-50. [PubMed: 16284651]  [MGI Ref ID J:104709]

Martin CE; van Leeuwen EM; Im SJ; Roopenian DC; Sung YC; Surh CD. 2013. IL-7/anti-IL-7 mAb complexes augment cytokine potency in mice through association with IgG-Fc and by competition with IL-7R. Blood 121(22):4484-92. [PubMed: 23610371]  [MGI Ref ID J:198495]

McPhee CG; Sproule TJ; Shin DM; Bubier JA; Schott WH; Steinbuck MP; Avenesyan L; Morse HC 3rd; Roopenian DC. 2011. MHC class I family proteins retard systemic lupus erythematosus autoimmunity and B cell lymphomagenesis. J Immunol 187(9):4695-704. [PubMed: 21964024]  [MGI Ref ID J:179430]

Mezo AR; McDonnell KA; Hehir CA; Low SC; Palombella VJ; Stattel JM; Kamphaus GD; Fraley C; Zhang Y; Dumont JA; Bitonti AJ. 2008. Reduction of IgG in nonhuman primates by a peptide antagonist of the neonatal Fc receptor FcRn. Proc Natl Acad Sci U S A 105(7):2337-42. [PubMed: 18272495]  [MGI Ref ID J:132181]

Nakata K; Kobayashi K; Ishikawa Y; Yamamoto M; Funada Y; Kotani Y; Blumberg RS; Karasuyama H; Yoshida M; Nishimura Y. 2010. The transfer of maternal antigen-specific IgG regulates the development of allergic airway inflammation early in life in an FcRn-dependent manner. Biochem Biophys Res Commun 395(2):238-43. [PubMed: 20362552]  [MGI Ref ID J:160346]

Patel DA; Puig-Canto A; Challa DK; Perez Montoyo H; Ober RJ; Ward ES. 2011. Neonatal Fc receptor blockade by Fc engineering ameliorates arthritis in a murine model. J Immunol 187(2):1015-22. [PubMed: 21690327]  [MGI Ref ID J:178025]

Roopenian DC; Christianson GJ; Sproule TJ. 2010. Human FcRn transgenic mice for pharmacokinetic evaluation of therapeutic antibodies. Methods Mol Biol 602:93-104. [PubMed: 20012394]  [MGI Ref ID J:170668]

Sarav M; Wang Y; Hack BK; Chang A; Jensen M; Bao L; Quigg RJ. 2009. Renal FcRn reclaims albumin but facilitates elimination of IgG. J Am Soc Nephrol 20(9):1941-52. [PubMed: 19661163]  [MGI Ref ID J:166328]

Stein C; Kling L; Proetzel G; Roopenian DC; de Angelis MH; Wolf E; Rathkolb B. 2011. Clinical chemistry of human FcRn transgenic mice. Mamm Genome :. [PubMed: 22193411]  [MGI Ref ID J:179989]

Stoklasek TA; Colpitts SL; Smilowitz HM; Lefrancois L. 2010. MHC Class I and TCR Avidity Control the CD8 T Cell Response to IL-15/IL-15R{alpha} Complex. J Immunol 185(11):6857-65. [PubMed: 21041729]  [MGI Ref ID J:166134]

Vidarsson G; Stemerding AM; Stapleton NM; Spliethoff SE; Janssen H; Rebers FE; de Haas M; van de Winkel JG. 2006. FcRn: an IgG receptor on phagocytes with a novel role in phagocytosis. Blood 108(10):3573-9. [PubMed: 16849638]  [MGI Ref ID J:140454]

Yoshida M; Kobayashi K; Kuo TT; Bry L; Glickman JN; Claypool SM; Kaser A; Nagaishi T; Higgins DE; Mizoguchi E; Wakatsuki Y; Roopenian DC; Mizoguchi A; Lencer WI; Blumberg RS. 2006. Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria. J Clin Invest 116(8):2142-2151. [PubMed: 16841095]  [MGI Ref ID J:113122]

Tg(CAG-FCGRT)276Dcr related

Andersen JT; Foss S; Kenanova VE; Olafsen T; Leikfoss IS; Roopenian DC; Wu AM; Sandlie I. 2012. Anti-carcinoembryonic antigen single-chain variable fragment antibody variants bind mouse and human neonatal Fc receptor with different affinities that reveal distinct cross-species differences in serum half-life. J Biol Chem 287(27):22927-37. [PubMed: 22570488]  [MGI Ref ID J:188378]

Kliwinski C; Cooper PR; Perkinson R; Mabus JR; Tam SH; Wilkinson TM; Giles-Komar J; Scallon B; Powers GD; Hornby PJ. 2013. Contribution of FcRn binding to intestinal uptake of IgG in suckling rat pups and human FcRn-transgenic mice. Am J Physiol Gastrointest Liver Physiol 304(3):G262-70. [PubMed: 23220220]  [MGI Ref ID J:194859]

Stein C; Kling L; Proetzel G; Roopenian DC; de Angelis MH; Wolf E; Rathkolb B. 2011. Clinical chemistry of human FcRn transgenic mice. Mamm Genome :. [PubMed: 22193411]  [MGI Ref ID J:179989]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX11

Colony Maintenance

Mating SystemSee Colony Maintenance under the Health & Care tab         (Female x Male)   21-SEP-10
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $232.00Female or MaleHomozygous for Fcgrttm1Dcr, Hemizygous for Tg(CAG-FCGRT)276Dcr  
$232.00Female or MaleHomozygous for Fcgrttm1Dcr, Homozygous for Tg(CAG-FCGRT)276Dcr  
Price per Pair (US dollars $)Pair Genotype
$464.00Homozygous for Fcgrttm1Dcr, Homozygous for Tg(CAG-FCGRT)276Dcr x Homozygous for Fcgrttm1Dcr, Homozygous for Tg(CAG-FCGRT)276Dcr  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $301.60Female or MaleHomozygous for Fcgrttm1Dcr, Hemizygous for Tg(CAG-FCGRT)276Dcr  
$301.60Female or MaleHomozygous for Fcgrttm1Dcr, Homozygous for Tg(CAG-FCGRT)276Dcr  
Price per Pair (US dollars $)Pair Genotype
$603.20Homozygous for Fcgrttm1Dcr, Homozygous for Tg(CAG-FCGRT)276Dcr x Homozygous for Fcgrttm1Dcr, Homozygous for Tg(CAG-FCGRT)276Dcr  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

  Control
   See control note: Stock No. 003982 is an appropriate experimental control as well.
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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Tel: 1-800-422-6423 or 1-207-288-5845
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Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Research institutions require an MTA, companies require a license prior to shipping.

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phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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