Strain Name:

NOD.MRL-Faslpr/Dvs

Stock Number:

004922

Availability:

Repository-Cryopreserved

Description

Strain Information

Former Names NOD.MRL-Tnfrsf6lpr/Dvs    (Changed: 26-JAN-05 )
Type Congenic; Mutant Strain; Spontaneous Mutation;
Additional information on Genetically Engineered Mutant Mice.
Specieslaboratory mouse
Background Strain NOD/LtDvs
Donor Strain MRL/MpJ-Faslpr/J

Development
The Faslpr mutation was backcrossed from MRL/MpJ-Faslpr/J onto NOD/LtDvs for 13 backcross generations in the laboratory of Dr. David Serreze. The strain was then intercrossed and made homozygous for Faslpr. It was cryopreserved in 2006 at generation N13F8.

Control Information

  Control
   001976 NOD/ShiLtJ
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Faslpr allele
000482   B6.MRL-Faslpr/J
000480   C3.MRL-Faslpr/J
002455   MRL-Faslpr.129P2(B6)-B2mtm1Unc
003896   MRL/MpJ Faslpr-Foxq1sa-J/J
006825   MRL/MpJ-Faslpr/2J
000485   MRL/MpJ-Faslpr/J
004519   NOD.MRL(C3)-Faslpr/DoiJ
View Strains carrying   Faslpr     (7 strains)

Strains carrying other alleles of Fas
003233   B6.129P2-Fastm1Osa/J
007895   C57BL/6-Fastm1Cgn/J
001876   CBA/KlJms-Faslpr-cg/J
003234   MRL.129P2(B6)-Fastm1Osa/J
002983   MRL.CBAJms-Faslpr-cg/J
View Strains carrying other alleles of Fas     (5 strains)

Additional Web Information

Congenic Nomenclature

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms
NOTDiabetes Mellitus, Insulin-Dependent; IDDM - No similarity to the expected human disease phenotype was found.4
4 One or more human genes are associated with this human disease. The mouse genotype may involve mutations to orthologs of one or more of those genes, but the phenotype did not resemble the disease.
View Mammalian Phenotype Terms

Mammalian Phenotype Terms
      assigned by genotype

Faslpr/Faslpr

        NOD.MRL(B6)-Faslpr
  • immune system phenotype
  • decreased susceptibility to autoimmune diabetes (MGI Ref ID J:64051)
    • during the 24 week period, no animals show diabetes or insulitis (mice are considered diabetic after a blood glucose measure of >300 mg/dl)

Faslpr/Faslpr

        NOD.MRL-Faslpr
  • immune system phenotype
  • decreased susceptibility to autoimmune diabetes (MGI Ref ID J:78679)
    • when mice are injected with islet specific CD8+ T cell clones, Faslpr mice are resistant to diabetogenic effect of injected T cells; 0/5 of Fas mutants are diabetic within 20 day observation period, while control NOD littermates become diabetic within 6 days
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Faslpr related

Apoptosis Research
Death Receptors

Cancer Research
Genes Regulating Growth and Proliferation

Immunology and Inflammation Research
Autoimmunity (lupus erythematosus: rheumatoid arthritis)
Inflammation (rheumatoid arthritis)

Mouse/Human Gene Homologs
autoimmune lymphoproliferative syndrome

Genes & Alleles

Gene & Allele Information

Allele Symbol Faslpr
Allele Name lymphoproliferation
Allele Type Spontaneous
Common Name(s) Fas-; Tnfrf6lpr; Tnfrsf6lpr; Tnfrsf6lpr; lpr;
Strain of OriginMRL/Mp
Gene Symbol and Name Fas, Fas (TNF receptor superfamily member 6)
Chromosome 19
Gene Common Name(s) AI196731; ALPS1A; APO-1; APT1; CD95; FAS1; FASTM; Fas antigen; TNFR6; TNFRSF6; Tnfrsf6; expressed sequence AI196731; lpr; lymphoproliferation; tumor necrosis factor receptor superfamily, member 6;
General Note Faslpr, lymphoproliferation, recessive. This mutation was found during inbreeding of a strain MRL/Mp derived from crosses among strains LG, AKR, C3H, and C57BL/6. The resemblance has led to extensive use of Faslpr mice in attemptsto determine the etiology of SLE and to evaluate therapies. However, the human APT1 gene (OMIM 134637) encodes the FAS antigen; Tnfrsf6 is not the homolog of the human (SLE) gene.
Molecular Note Southern blotting experiments indicated that the mutation is a genomic rearrangement within the gene, probably within intron 2. [MGI Ref ID J:1181] [MGI Ref ID J:140028] [MGI Ref ID J:14206] [MGI Ref ID J:14503] [MGI Ref ID J:15429] [MGI Ref ID J:4166] [MGI Ref ID J:4342] [MGI Ref ID J:72675] [MGI Ref ID J:92470]

Genotyping

Genotyping Information

Genotyping Protocols

Faslpr, SEP PCR, vers. 2

Helpful Links

Optimizing PCR Protocols

References

References

Additional References

Faslpr related

Adachi K; Tsutsui H; Kashiwamura S; Seki E; Nakano H; Takeuchi O; Takeda K; Okumura K; Van Kaer L; Okamura H; Akira S; Nakanishi K. 2001. Plasmodium berghei infection in mice induces liver injury by an IL-12- and toll-like receptor/myeloid differentiation factor 88-dependent mechanism. J Immunol 167(10):5928-34. [PubMed: 11698470]  [MGI Ref ID J:118004]

Adachi M; Watanabe-Fukunaga R; Nagata S. 1993. Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice. Proc Natl Acad Sci U S A 90(5):1756-60. [PubMed: 7680478]  [MGI Ref ID J:4342]

Aicher WK; Fujihashi K; Yamamoto M; Kiyono H; Pitts AM; McGhee JR. 1992. Effects of the lpr/lpr mutation on T and B cell populations in the lamina propria of the small intestine, a mucosal effector site. Int Immunol 4(9):959-68. [PubMed: 1390438]  [MGI Ref ID J:3154]

Akashi T; Nagafuchi S; Anzai K; Kitamura D; Wang J; Taniuchi I; Niho Y; Watanabe T. 1998. Proliferation of CD3+ B220- single-positive normal T cells was suppressed in B-cell-deficient lpr mice. Immunology 93(2):238-48. [PubMed: 9616374]  [MGI Ref ID J:45808]

Alarcon-Riquelme ME; Fernandez C. 1995. CDR3 regions in the preimmune VH B cell repertoire of lpr mice. Clin Exp Immunol 101(1):73-7. [PubMed: 7621595]  [MGI Ref ID J:26829]

Alarcon-Riquelme ME; Fernandez C. 1995. Expression of the B cell repertoire in lpr mice; abnormal expansion of a few VHJ558 germ-line genes. Clin Exp Immunol 99(2):262-8. [PubMed: 7851020]  [MGI Ref ID J:22861]

Alenzi FQ; Marley SB; Lewis JL; Chandrashekran A; Warrens AN; Goldman JM; Gordon MY. 2002. A role for the Fas/Fas ligand apoptotic pathway in regulating myeloid progenitor cell kinetics. Exp Hematol 30(12):1428-35. [PubMed: 12482505]  [MGI Ref ID J:118008]

Alexander JJ; Jacob A; Bao L; Macdonald RL; Quigg RJ. 2005. Complement-dependent apoptosis and inflammatory gene changes in murine lupus cerebritis. J Immunol 175(12):8312-9. [PubMed: 16339572]  [MGI Ref ID J:122254]

Alexander JJ; Jacob A; Vezina P; Sekine H; Gilkeson GS; Quigg RJ. 2007. Absence of functional alternative complement pathway alleviates lupus cerebritis. Eur J Immunol 37(6):1691-701. [PubMed: 17523212]  [MGI Ref ID J:123511]

Alexander JJ; Zwingmann C; Jacob A; Quigg R. 2007. Alteration in kidney glucose and amino acids are implicated in renal pathology in MRL/lpr mice. Biochim Biophys Acta 1772(10):1143-9. [PubMed: 17942282]  [MGI Ref ID J:130687]

Alexander JJ; Zwingmann C; Quigg R. 2005. MRL/lpr mice have alterations in brain metabolism as shown with [1H-13C] NMR spectroscopy. Neurochem Int 47(1-2):143-51. [PubMed: 15893408]  [MGI Ref ID J:129820]

Ali M; Weinreich M; Balcaitis S; Cooper CJ; Fink PJ. 2003. Differential regulation of peripheral CD4+ T cell tolerance induced by deletion and TCR revision. J Immunol 171(11):6290-6. [PubMed: 14634147]  [MGI Ref ID J:132828]

Allison J; Thomas HE; Catterall T; Kay TW; Strasser A. 2005. Transgenic expression of dominant-negative Fas-associated death domain protein in beta cells protects against Fas ligand-induced apoptosis and reduces spontaneous diabetes in nonobese diabetic mice. J Immunol 175(1):293-301. [PubMed: 15972661]  [MGI Ref ID J:100606]

Alsharifi M; Lobigs M; Simon MM; Kersten A; Muller K; Koskinen A; Lee E; Mullbacher A. 2006. NK cell-mediated immunopathology during an acute viral infection of the CNS. Eur J Immunol 36(4):887-96. [PubMed: 16541469]  [MGI Ref ID J:114787]

Altman A. 1994. Abnormal antigen receptor-initiated signal transduction in lpr T lymphocytes. Semin Immunol 6(1):9-17. [PubMed: 7513195]  [MGI Ref ID J:19053]

Amital H; Heilweil M; Ulmansky R; Szafer F; Bar-Tana R; Morel L; Foster MH; Mostoslavsky G; Eilat D; Pizov G; Naparstek Y. 2005. Treatment with a laminin-derived peptide suppresses lupus nephritis. J Immunol 175(8):5516-23. [PubMed: 16210660]  [MGI Ref ID J:119103]

Anderson CC; Mukherjee R; Sinclair NR; Jevnikar AM. 1997. Hypogammaglobulinaemia occurs in Fas-deficient MRL-lpr mice following deletion of MHC class II molecules. Clin Exp Immunol 109(3):473-9. [PubMed: 9328125]  [MGI Ref ID J:42959]

Andrews BS; Eisenberg RA; Theofilopoulos AN; Izui S; Wilson CB; McConahey PJ; Murphy ED; Roths JB; Dixon FJ. 1978. Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains. J Exp Med 148(5):1198-215. [PubMed: 309911]  [MGI Ref ID J:27634]

Apte RS; Richter J; Herndon J; Ferguson TA. 2006. Macrophages inhibit neovascularization in a murine model of age-related macular degeneration. PLoS Med 3(8):e310. [PubMed: 16903779]  [MGI Ref ID J:134144]

Arens R; Baars PA; Jak M; Tesselaar K; van der Valk M; van Oers MH; van Lier RA. 2005. Cutting edge: CD95 maintains effector T cell homeostasis in chronic immune activation. J Immunol 174(10):5915-20. [PubMed: 15879081]  [MGI Ref ID J:98994]

Ashany D; Savir A; Bhardwaj N; Elkon KB. 1999. Dendritic cells are resistant to apoptosis through the Fas (CD95/APO-1) pathway. J Immunol 163(10):5303-11. [PubMed: 10553053]  [MGI Ref ID J:118433]

Balasa B; Van Gunst K; Jung N; Balakrishna D; Santamaria P; Hanafusa T; Itoh N; Sarvetnick N. 2000. Islet-specific expression of IL-10 promotes diabetes in nonobese diabetic mice independent of Fas, perforin, TNF receptor-1, and TNF receptor-2 molecules. J Immunol 165(5):2841-9. [PubMed: 10946317]  [MGI Ref ID J:64051]

Balkow S; Kersten A; Tran TT; Stehle T; Grosse P; Museteanu C; Utermohlen O; Pircher H; von Weizsacker F; Wallich R; Mullbacher A; Simon MM. 2001. Concerted action of the FasL/Fas and perforin/granzyme A and B pathways is mandatory for the development of early viral hepatitis but not for recovery from viral infection. J Virol 75(18):8781-91. [PubMed: 11507223]  [MGI Ref ID J:71217]

Bao L; Haas M; Boackle SA; Kraus DM; Cunningham PN; Park P; Alexander JJ; Anderson RK; Culhane K; Holers VM; Quigg RJ. 2002. Transgenic expression of a soluble complement inhibitor protects against renal disease and promotes survival in MRL/lpr mice. J Immunol 168(7):3601-7. [PubMed: 11907125]  [MGI Ref ID J:75572]

Bao L; Osawe I; Haas M; Quigg RJ. 2005. Signaling through up-regulated C3a receptor is key to the development of experimental lupus nephritis. J Immunol 175(3):1947-55. [PubMed: 16034139]  [MGI Ref ID J:107265]

Barazzone C; Horowitz S; Donati YR; Rodriguez I; Piguet PF. 1998. Oxygen toxicity in mouse lung: pathways to cell death. Am J Respir Cell Mol Biol 19(4):573-81. [PubMed: 9761753]  [MGI Ref ID J:51593]

Barreiro R; Luker G; Herndon J; Ferguson TA. 2004. Termination of antigen-specific immunity by CD95 ligand (Fas ligand) and IL-10. J Immunol 173(3):1519-25. [PubMed: 15265879]  [MGI Ref ID J:92022]

Barrington RA; Zhang M; Zhong X; Jonsson H; Holodick N; Cherukuri A; Pierce SK; Rothstein TL; Carroll MC. 2005. CD21/CD19 coreceptor signaling promotes B cell survival during primary immune responses. J Immunol 175(5):2859-67. [PubMed: 16116172]  [MGI Ref ID J:113242]

Bernstein KA; Bolshoun D; Lefkowith JB. 1993. Serum glomerular binding activity is highly correlated with renal disease in MRL/lpr mice. Clin Exp Immunol 93(3):418-23. [PubMed: 8370169]  [MGI Ref ID J:15039]

Bhandoola A; Yui K; Siegel RM; Zerva L; Greene MI. 1994. Gld and lpr mice: single gene mutant models for failed self tolerance. Int Rev Immunol 11(3):231-44. [PubMed: 7930847]  [MGI Ref ID J:21989]

Bloch DB; Rabkina D; Bloch KD. 1995. The cell proliferation-associated protein Ki-67 is a target of autoantibodies in the serum of MRL mice. Lab Invest 73(3):366-71. [PubMed: 7564269]  [MGI Ref ID J:28749]

Bloom DD; Davignon JL; Cohen PL; Eisenberg RA; Clarke SH. 1993. Overlap of the anti-Sm and anti-DNA responses of MRL/Mp-lpr/lpr mice. J Immunol 150(4):1579-90. [PubMed: 8432994]  [MGI Ref ID J:3924]

Bolland S; Yim YS; Tus K; Wakeland EK; Ravetch JV. 2002. Genetic modifiers of systemic lupus erythematosus in FcgammaRIIB(-/-) mice. J Exp Med 195(9):1167-74. [PubMed: 11994421]  [MGI Ref ID J:76486]

Bonardelle D; Benihoud K; Kiger N; Bobe P. 2005. B lymphocytes mediate Fas-dependent cytotoxicity in MRL/lpr mice. J Leukoc Biol 78(5):1052-1059. [PubMed: 16204618]  [MGI Ref ID J:102764]

Booker JK; Reap EA; Cohen PL. 1998. Expression and function of Fas on cells damaged by gamma-irradiation in B6 and B6/lpr mice. J Immunol 161(9):4536-41. [PubMed: 9794379]  [MGI Ref ID J:112150]

Boone DL; Dassopoulos T; Chai S; Chien M; Lodolce J; Ma A. 2003. Fas is not essential for lamina propria T lymphocyte homeostasis. Am J Physiol Gastrointest Liver Physiol 285(2):G382-8. [PubMed: 12702495]  [MGI Ref ID J:84826]

Bossu P; Singer GG; Andres P; Ettinger R; Marshak-Rothstein A; Abbas AK. 1993. Mature CD4+ T lymphocytes from MRL/lpr mice are resistant to receptor-mediated tolerance and apoptosis. J Immunol 151(12):7233-9. [PubMed: 7903104]  [MGI Ref ID J:16035]

Bour-Jordan H; Thompson HL; Bluestone JA. 2005. Distinct effector mechanisms in the development of autoimmune neuropathy versus diabetes in nonobese diabetic mice. J Immunol 175(9):5649-55. [PubMed: 16237054]  [MGI Ref ID J:119359]

Bowen DG; Warren A; Davis T; Hoffmann MW; McCaughan GW; De St Groth BF; Bertolino P. 2002. Cytokine-dependent bystander hepatitis due to intrahepatic murine CD8 T-cell activation by bone marrow-derived cells. Gastroenterology 123(4):1252-64. [PubMed: 12360486]  [MGI Ref ID J:79335]

Bradshaw S; Zheng WJ; Tsoi LC; Gilkeson G; Zhang XK. 2008. A role for Fli-1 in B cell proliferation: implications for SLE pathogenesis. Clin Immunol 129(1):19-30. [PubMed: 18692443]  [MGI Ref ID J:140403]

Brard F; Shannon M; Prak EL; Litwin S; Weigert M. 1999. Somatic mutation and light chain rearrangement generate autoimmunity in anti-single-stranded DNA transgenic MRL/lpr mice. J Exp Med 190(5):691-704. [PubMed: 10477553]  [MGI Ref ID J:57612]

Braun D; Geraldes P; Demengeot J. 2003. Type I Interferon controls the onset and severity of autoimmune manifestations in lpr mice. J Autoimmun 20(1):15-25. [PubMed: 12604309]  [MGI Ref ID J:82338]

Breneman SM; Moynihan JA; Grota LJ; Felten DL; Felten SY. 1993. Splenic norepinephrine is decreased in MRL-lpr/lpr mice. Brain Behav Immun 7(2):135-43. [PubMed: 8347895]  [MGI Ref ID J:12758]

Brown NJ; Hutcheson J; Bickel E; Scatizzi JC; Albee LD; Haines GK rd; Eslick J; Bradley K; Taricone E; Perlman H. 2004. Fas death receptor signaling represses monocyte numbers and macrophage activation in vivo. J Immunol 173(12):7584-93. [PubMed: 15585886]  [MGI Ref ID J:94851]

Brownlie RJ; Lawlor KE; Niederer HA; Cutler AJ; Xiang Z; Clatworthy MR; Floto RA; Greaves DR; Lyons PA; Smith KG. 2008. Distinct cell-specific control of autoimmunity and infection by FcgammaRIIb. J Exp Med 205(4):883-95. [PubMed: 18362174]  [MGI Ref ID J:133975]

Brummel R; Roberts TL; Stacey KJ; Lenert P. 2006. Higher-order CpG-DNA stimulation reveals distinct activation requirements for marginal zone and follicular B cells in lupus mice. Eur J Immunol 36(7):1951-62. [PubMed: 16791898]  [MGI Ref ID J:115797]

Budd RC; Van Houten N; Clements J; Mixter PF. 1994. Parallels in T lymphocyte development between lpr and normal mice. Semin Immunol 6(1):43-8. [PubMed: 8167306]  [MGI Ref ID J:19056]

Bullard DC; King PD; Hicks MJ; Dupont B; Beaudet AL; Elkon KB. 1997. Intercellular adhesion molecule-1 deficiency protects MRL/MpJ-Fas(lpr) mice from early lethality. J Immunol 159(4):2058-67. [PubMed: 9257874]  [MGI Ref ID J:42669]

Buonocore S; Haddou NO; Moore F; Florquin S; Paulart F; Heirman C; Thielemans K; Goldman M; Flamand V. 2008. Neutrophil-dependent tumor rejection and priming of tumoricidal CD8+ T cell response induced by dendritic cells overexpressing CD95L. J Leukoc Biol 84(3):713-20. [PubMed: 18567840]  [MGI Ref ID J:138270]

Busser BW; Cancro MP; Laufer TM. 2004. An increased frequency of autoantibody-inducing CD4+ T cells in pre-diseased lupus-prone mice. Int Immunol 16(7):1001-7. [PubMed: 15159378]  [MGI Ref ID J:90761]

Carvalho-Pinto CE; Garcia MI; Mellado M; Rodriguez-Frade JM; Martin-Caballero J; Flores J; Martinez-A C; Balomenos D. 2002. Autocrine production of IFN-gamma by macrophages controls their recruitment to kidney and the development of glomerulonephritis in MRL/lpr mice. J Immunol 169(2):1058-67. [PubMed: 12097414]  [MGI Ref ID J:123834]

Catterall T; Stockwell D; Marshall V; Strasser A; Allison J. 2003. Autoimmune kidney disease and lymphadenopathy in NODlpr mice are not modified by deficiency in tumor necrosis factor receptor 1 or beta(2)-microglobulin. Int Immunol 15(6):679-90. [PubMed: 12750352]  [MGI Ref ID J:83719]

Caucheteux SM; Gendron MC; Kanellopoulos-Langevin C. 2005. Pregnancy-induced alterations of B cell maturation and survival are differentially affected by Fas and Bcl-2, independently of BcR expression. Int Immunol 17(1):55-63. [PubMed: 15569774]  [MGI Ref ID J:94796]

Chakour R; Guler R; Bugnon M; Allenbach C; Garcia I; Mauel J; Louis J; Tacchini-Cottier F. 2003. Both the Fas ligand and inducible nitric oxide synthase are needed for control of parasite replication within lesions in mice infected with Leishmania major whereas the contribution of tumor necrosis factor is minimal. Infect Immun 71(9):5287-95. [PubMed: 12933876]  [MGI Ref ID J:85214]

Chan O; Shlomchik MJ. 1998. A new role for B cells in systemic autoimmunity: B cells promote spontaneous T cell activation in MRL-lpr/lpr mice. J Immunol 160(1):51-9. [PubMed: 9551955]  [MGI Ref ID J:44923]

Chan OT; Paliwal V; McNiff JM; Park SH; Bendelac A; Shlomchik MJ. 2001. Deficiency in beta(2)-Microglobulin, But Not CD1, Accelerates Spontaneous Lupus Skin Disease While Inhibiting Nephritis in MRL-Fas(lpr) Mice: An Example of Disease Regulation at the Organ Level. J Immunol 167(5):2985-90. [PubMed: 11509649]  [MGI Ref ID J:71175]

Chastagner P; Reddy J; Theze J. 2002. Lymphoadenopathy in IL-2-Deficient Mice: Further Characterization and Overexpression of the Antiapoptotic Molecule Cellular FLIP. J Immunol 169(7):3644-51. [PubMed: 12244156]  [MGI Ref ID J:79241]

Chen C; Li H; Tian Q; Beardall M; Xu Y; Casanova N; Weigert M. 2006. Selection of anti-double-stranded DNA B cells in autoimmune MRL-lpr/lpr mice. J Immunol 176(9):5183-90. [PubMed: 16621982]  [MGI Ref ID J:131631]

Chen M; Wang YH; Wang Y; Huang L; Sandoval H; Liu YJ; Wang J. 2006. Dendritic cell apoptosis in the maintenance of immune tolerance. Science 311(5764):1160-4. [PubMed: 16497935]  [MGI Ref ID J:105747]

Chen Z; Koralov SB; Kelsoe G. 2000. Complement C4 inhibits systemic autoimmunity through a mechanism independent of complement receptors CR1 and CR2. J Exp Med 192(9):1339-52. [PubMed: 11067882]  [MGI Ref ID J:111811]

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Chu JL; Drappa J; Parnassa A; Elkon KB. 1993. The defect in Fas mRNA expression in MRL/lpr mice is associated with insertion of the retrotransposon, ETn. J Exp Med 178(2):723-30. [PubMed: 7688033]  [MGI Ref ID J:14206]

Chu JL; Ramos P; Rosendorff A; Nikolic-Zugic J; Lacy E; Matsuzawa A; Elkon KB. 1995. Massive upregulation of the Fas ligand in lpr and gld mice: implications for Fas regulation and the graft-versus-host disease-like wasting syndrome. J Exp Med 181(1):393-8. [PubMed: 7528774]  [MGI Ref ID J:22200]

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Colino J; Snapper CM. 2003. Two distinct mechanisms for induction of dendritic cell apoptosis in response to intact Streptococcus pneumoniae. J Immunol 171(5):2354-65. [PubMed: 12928382]  [MGI Ref ID J:121185]

Conceicao-Silva F; Hahne M; Schroter M; Louis J; Tschopp J. 1998. The resolution of lesions induced by Leishmania major in mice requires a functional Fas (APO-1, CD95) pathway of cytotoxicity Eur J Immunol 28(1):237-45. [PubMed: 9485203]  [MGI Ref ID J:45903]

Cruse JM; Lewis RE; Dilioglou S. 2000. Fate of immune complexes, glomerulonephritis, and cell-mediated vasculitis in lupus-prone MRL/Mp lpr/lpr mice. Exp Mol Pathol 69(3):211-22. [PubMed: 11115362]  [MGI Ref ID J:106331]

Cui H; Ju ST; Sherr DH. 1996. Functional expression of Fas (CD95) protein in autoimmune lpr mice. Cell Immunol 174(1):35-41. [PubMed: 8929452]  [MGI Ref ID J:36837]

Cullen CM; Bonventre PF; Heeg H; Bluethmann H; Mountz JD; Edwards CK 3rd. 1995. A fas antigen receptor mutation allows development of toxic shock syndrome toxin-1-induced lethal shock in V beta 8.2 T-cell receptor transgenic mice. Pathobiology 63(6):293-304. [PubMed: 8738468]  [MGI Ref ID J:33149]

Dai Z; Nasr IW; Reel M; Deng S; Diggs L; Larsen CP; Rothstein DM; Lakkis FG. 2005. Impaired recall of CD8 memory T cells in immunologically privileged tissue. J Immunol 174(3):1165-70. [PubMed: 15661869]  [MGI Ref ID J:135113]

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