Strain Name:

NOD.Cg-Selltm1Tft Itgb7tm1Cgn/LtJ

Stock Number:

004943

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Cryopreserved - Ready for recovery

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Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names NOD.Cg-Selltm1Tft Itgb7tm1Cgn/Lt    (Changed: 12-JUL-05 )
Type Congenic; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
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Additional information on Congenic nomenclature.
Specieslaboratory mouse
Background Strain NOD/ShiLt
Donor Strain Selltm1Tft: 129P2/OlaHsd via ES cell line E14.1. Itgb7tm1Cgn: C57BL/6
H2 Haplotypeg7
 
Donating InvestigatorDr. Edward Leiter,   The Jackson Laboratory

Appearance
albino
Related Genotype: A/A Tyrc/Tyrc

Development
This strain was derived from a cross between mice of strains NOD.B6-Itgb7tm1Cgn/Lt (Stock No. 004310), then at backcross generation N9, and NOD.129P2(B6)-Selltm1Tft/1Lt (Stock No. 3860), at backcross generation N10. Dr. Leiter transferred this stock to the T1DR in 2005.

Control Information

  Control
   001976 NOD/ShiLtJ
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Itgb7tm1Cgn allele
002965   C57BL/6-Itgb7tm1Cgn/J
004944   NOD.B6-Itgb7tm1Cgn/2LtJ
View Strains carrying   Itgb7tm1Cgn     (2 strains)

Strains carrying   Selltm1Tft allele
003860   NOD.129P2(B6)-Selltm1Tft/1LtJ
View Strains carrying   Selltm1Tft     (1 strain)

Strains carrying other alleles of Itgb7
007707   C57BL/6-Itgb7tm1Mshi/J
View Strains carrying other alleles of Itgb7     (1 strain)

View Strains carrying other alleles of Sell     (9 strains)

Phenotype

Phenotype Information

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Itgb7tm1Cgn related

Cell Biology Research
Defects in Cell Adhesion Molecules

Immunology, Inflammation and Autoimmunity Research
Growth Factors/Receptors/Cytokines
Lymphoid Tissue Defects

Selltm1Tft related
CD Antigens, Antigen Receptors, and Histocompatibility Markers

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Itgb7tm1Cgn
Allele Name targeted mutation 1, University of Cologne
Allele Type Targeted (Null/Knockout)
Common Name(s) Itgbtm1Ctg; beta7-;
Mutation Made By Norbert Wagner,   University of Cologne
Strain of OriginC57BL/6J
ES Cell Line NameBL/6-III
ES Cell Line StrainC57BL/6J
Gene Symbol and Name Itgb7, integrin beta 7
Chromosome 15
Molecular Note A neomycin resistance cassette replaced part of exon 12 and all of exons 13 and 14, which encode the transmembrane and part of the extracellular domains. [MGI Ref ID J:34306]
 
Allele Symbol Selltm1Tft
Allele Name targeted mutation 1, Thomas F Tedder
Allele Type Targeted (Null/Knockout)
Common Name(s) CD62L KO; CD62L-; L-selectin-; L-; selectin-;
Mutation Made ByDr. Thomas Tedder,   Duke University Medical Center
Strain of Origin129P2/OlaHsd
ES Cell Line NameE14.1
ES Cell Line Strain129P2/OlaHsd
Gene Symbol and Name Sell, selectin, lymphocyte
Chromosome 1
Gene Common Name(s) A.11; AI528707; CD62L; L-selectin; LAM1; LECAM-1; LECAM1; LEU8; LNHR; LSEL; LYAM1; Lnhr; Ly-22; Ly-m22; Lyam-1; Lyam1; PLNHR; TQ1; expressed sequence AI528707; lymph node homing receptor; lymphocyte adhesion molecule 1; lymphocyte antigen 22; lymphocyte antigen m22;
Molecular Note A neomycin resistance gene replaced the majority of the exon encoding the L-selectin domain. [MGI Ref ID J:25005]

Genotyping

Genotyping Information

Genotyping Protocols

Itgb7tm1Cgn, High Resolution Melting
Itgb7tm1Cgn, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Itgb7tm1Cgn related

Abonia JP; Hallgren J; Jones T; Shi T; Xu Y; Koni P; Flavell RA; Boyce JA; Austen KF; Gurish MF. 2006. Alpha-4 integrins and VCAM-1, but not MAdCAM-1, are essential for recruitment of mast cell progenitors to the inflamed lung. Blood 108(5):1588-94. [PubMed: 16670268]  [MGI Ref ID J:138072]

Agnello D; Denimal D; Lavaux A; Blondeau-Germe L; Lu B; Gerard NP; Gerard C; Pothier P. 2013. Intrarectal immunization and IgA antibody-secreting cell homing to the small intestine. J Immunol 190(9):4836-47. [PubMed: 23547118]  [MGI Ref ID J:195497]

Apostolaki M; Manoloukos M; Roulis M; Wurbel MA; Muller W; Papadakis KA; Kontoyiannis DL; Malissen B; Kollias G. 2008. Role of beta7 integrin and the chemokine/chemokine receptor pair CCL25/CCR9 in modeled TNF-dependent Crohn's disease. Gastroenterology 134(7):2025-35. [PubMed: 18439426]  [MGI Ref ID J:136667]

Artis D; Humphreys NE; Potten CS; Wagner N; Muller W; McDermott JR; Grencis RK; Else KJ. 2000. Beta7 integrin-deficient mice: delayed leukocyte recruitment and attenuated protective immunity in the small intestine during enteric helminth infection Eur J Immunol 30(6):1656-64. [PubMed: 10898502]  [MGI Ref ID J:62733]

Berberich S; Dahne S; Schippers A; Peters T; Muller W; Kremmer E; Forster R; Pabst O. 2008. Differential molecular and anatomical basis for B cell migration into the peritoneal cavity and omental milky spots. J Immunol 180(4):2196-203. [PubMed: 18250426]  [MGI Ref ID J:132002]

Bry L; Brenner MB. 2004. Critical role of T cell-dependent serum antibody, but not the gut-associated lymphoid tissue, for surviving acute mucosal infection with Citrobacter rodentium, an attaching and effacing pathogen. J Immunol 172(1):433-41. [PubMed: 14688352]  [MGI Ref ID J:87077]

Collins CB; Ho J; Wilson TE; Wermers JD; Tlaxca JL; Lawrence MB; Solga M; Lannigan J; Rivera-Nieves J. 2008. CD44 deficiency attenuates chronic murine ileitis. Gastroenterology 135(6):1993-2002. [PubMed: 18854186]  [MGI Ref ID J:145626]

Croy BA; Ashkar AA; Foster RA; DiSanto JP; Magram J; Carson D; Gendler SJ; Grusby MJ; Wagner N; Muller W; Guimond MJ. 1997. Histological studies of gene-ablated mice support important functional roles for natural killer cells in the uterus during pregnancy J Reprod Immunol 35(2):111-33. [PubMed: 9421796]  [MGI Ref ID J:44813]

Czarneski J; Berguer P; Bekinschtein P; Kim DC; Hakimpour P; Wagner N; Nepomnaschy I; Piazzon I; Ross SR. 2002. Neonatal infection with a milk-borne virus is independent of beta7 integrin- and L-selectin-expressing lymphocytes. Eur J Immunol 32(4):945-56. [PubMed: 11920560]  [MGI Ref ID J:76001]

DeNucci CC; Pagan AJ; Mitchell JS; Shimizu Y. 2010. Control of alpha4beta7 integrin expression and CD4 T cell homing by the beta1 integrin subunit. J Immunol 184(5):2458-67. [PubMed: 20118278]  [MGI Ref ID J:159655]

Denucci CC; Shimizu Y. 2011. {beta}1 Integrin Is Critical for the Maintenance of Antigen-Specific CD4 T Cells in the Bone Marrow but Not Long-Term Immunological Memory. J Immunol 186(7):4019-26. [PubMed: 21357540]  [MGI Ref ID J:170691]

Dutt S; Ermann J; Tseng D; Liu YP; George TI; Fathman CG; Strober S. 2005. L-selectin and beta7 integrin on donor CD4 T cells are required for the early migration to host mesenteric lymph nodes and acute colitis of graft-versus-host disease. Blood 106(12):4009-15. [PubMed: 16105972]  [MGI Ref ID J:124067]

Fernekorn U; Butcher EC; Behrends J; Hartz S; Kruse A. 2004. Functional involvement of P-selectin and MAdCAM-1 in the recruitment of alpha4beta7-integrin-expressing monocyte-like cells to the pregnant mouse uterus. Eur J Immunol 34(12):3423-33. [PubMed: 15484189]  [MGI Ref ID J:94597]

Forbes E; Hulett M; Ahrens R; Wagner N; Smart V; Matthaei KI; Brandt EB; Dent LA; Rothenberg ME; Tang M; Foster PS; Hogan SP. 2006. ICAM-1-dependent pathways regulate colonic eosinophilic inflammation. J Leukoc Biol 80(2):330-41. [PubMed: 16731772]  [MGI Ref ID J:111227]

Ghosh S; Chackerian AA; Parker CM; Ballantyne CM; Behar SM. 2006. The LFA-1 adhesion molecule is required for protective immunity during pulmonary Mycobacterium tuberculosis infection. J Immunol 176(8):4914-22. [PubMed: 16585587]  [MGI Ref ID J:131154]

Gorfu G; Rivera-Nieves J; Hoang S; Abbott DW; Arbenz-Smith K; Azar DW; Pizarro TT; Cominelli F; McDuffie M; Ley K. 2010. Beta7 integrin deficiency suppresses B cell homing and attenuates chronic ileitis in SAMP1/YitFc mice. J Immunol 185(9):5561-8. [PubMed: 20926792]  [MGI Ref ID J:165177]

Gurish MF; Tao H; Abonia JP; Arya A; Friend DS; Parker CM; Austen KF. 2001. Intestinal mast cell progenitors require CD49dbeta7 (alpha4beta7 integrin) for tissue-specific homing. J Exp Med 194(9):1243-52. [PubMed: 11696590]  [MGI Ref ID J:119138]

Hadis U; Wahl B; Schulz O; Hardtke-Wolenski M; Schippers A; Wagner N; Muller W; Sparwasser T; Forster R; Pabst O. 2011. Intestinal Tolerance Requires Gut Homing and Expansion of FoxP3(+) Regulatory T Cells in the Lamina Propria. Immunity 34(2):237-46. [PubMed: 21333554]  [MGI Ref ID J:168976]

Ho J; Kurtz CC; Naganuma M; Ernst PB; Cominelli F; Rivera-Nieves J. 2008. A CD8+/CD103high T cell subset regulates TNF-mediated chronic murine ileitis. J Immunol 180(4):2573-80. [PubMed: 18250468]  [MGI Ref ID J:131978]

Karsten CM; Behrends J; Wagner AK; Fuchs F; Figge J; Schmudde I; Hellberg L; Kruse A. 2009. DC within the pregnant mouse uterus influence growth and functional properties of uterine NK cells. Eur J Immunol 39(8):2203-14. [PubMed: 19593769]  [MGI Ref ID J:151694]

Kuklin NA; Rott L; Feng N; Conner ME; Wagner N; Muller W; Greenberg HB. 2001. Protective intestinal anti-rotavirus B cell immunity is dependent on alpha(4)beta(7) integrin expression but does not require IgA antibody production. J Immunol 166(3):1894-902. [PubMed: 11160237]  [MGI Ref ID J:67098]

Kunkel EJ; Ramos CL; Steeber DA; Muller W; Wagner N; Tedder TF; Ley K. 1998. The roles of L-selectin, beta 7 integrins, and P-selectin in leukocyte rolling and adhesion in high endothelial venules of Peyer's patches. J Immunol 161(5):2449-56. [PubMed: 9725243]  [MGI Ref ID J:112049]

Lammermann T; Bader BL; Monkley SJ; Worbs T; Wedlich-Soldner R; Hirsch K; Keller M; Forster R; Critchley DR; Fassler R; Sixt M. 2008. Rapid leukocyte migration by integrin-independent flowing and squeezing. Nature 453(7191):51-5. [PubMed: 18451854]  [MGI Ref ID J:134784]

Mancassola R; Lacroix-Lamande S; Barrier M; Naciri M; Salmon H; Laurent F. 2004. Increased susceptibility of beta7-integrin-deficient neonatal mice in the early stage of Cryptosporidium parvum infection. Infect Immun 72(6):3634-7. [PubMed: 15155674]  [MGI Ref ID J:90262]

Park EJ; Mora JR; Carman CV; Chen J; Sasaki Y; Cheng G; von Andrian UH; Shimaoka M. 2007. Aberrant activation of integrin alpha4beta7 suppresses lymphocyte migration to the gut. J Clin Invest 117(9):2526-38. [PubMed: 17786243]  [MGI Ref ID J:127413]

Quast T; Tappertzhofen B; Schild C; Grell J; Czeloth N; Forster R; Alon R; Fraemohs L; Dreck K; Weber C; Lammermann T; Sixt M; Kolanus W. 2009. Cytohesin-1 controls the activation of RhoA and modulates integrin-dependent adhesion and migration of dendritic cells. Blood 113(23):5801-10. [PubMed: 19346499]  [MGI Ref ID J:149500]

Schippers A; Kochut A; Pabst O; Frischmann U; Clahsen T; Tenbrock K; Muller W; Wagner N. 2012. beta7 integrin controls immunogenic and tolerogenic mucosal B cell responses. Clin Immunol 144(2):87-97. [PubMed: 22710445]  [MGI Ref ID J:188011]

Steeber DA; Tang ML; Zhang XQ; Muller W; Wagner N; Tedder TF. 1998. Efficient lymphocyte migration across high endothelial venules of mouse Peyer's patches requires overlapping expression of L-selectin and beta7 integrin. J Immunol 161(12):6638-47. [PubMed: 9862692]  [MGI Ref ID J:112112]

Sydora BC; Wagner N; Lohler J; Yakoub G; Kronenberg M; Muller W; Aranda R. 2002. beta7 Integrin expression is not required for the localization of T cells to the intestine and colitis pathogenesis. Clin Exp Immunol 129(1):35-42. [PubMed: 12100020]  [MGI Ref ID J:115570]

Tu L; Poe JC; Kadono T; Venturi GM; Bullard DC; Tedder TF; Steeber DA. 2002. A functional role for circulating mouse L-selectin in regulating leukocyte/endothelial cell interactions in vivo. J Immunol 169(4):2034-43. [PubMed: 12165530]  [MGI Ref ID J:120206]

Wagner N; Lohler J; Kunkel EJ; Ley K; Leung E; Krissansen G; Rajewsky K; Muller W. 1996. Critical role for beta7 integrins in formation of the gut-associated lymphoid tissue. Nature 382(6589):366-70. [PubMed: 8684468]  [MGI Ref ID J:34306]

Wagner N; Lohler J; Tedder TF; Rajewsky K; Muller W; Steeber DA. 1998. L-selectin and beta7 integrin synergistically mediate lymphocyte migration to mesenteric lymph nodes. Eur J Immunol 28(11):3832-9. [PubMed: 9842926]  [MGI Ref ID J:114211]

Waldman E; Lu SX; Hubbard VM; Kochman AA; Eng JM; Terwey TH; Muriglan SJ; Kim TD; Heller G; Murphy GF; Liu C; Alpdogan O; van den Brink MR. 2006. Absence of beta7 integrin results in less graft-versus-host disease because of decreased homing of alloreactive T cells to intestine. Blood 107(4):1703-11. [PubMed: 16291587]  [MGI Ref ID J:129395]

Wang C; Kang SG; HogenEsch H; Love PE; Kim CH. 2010. Retinoic acid determines the precise tissue tropism of inflammatory Th17 cells in the intestine. J Immunol 184(10):5519-26. [PubMed: 20400707]  [MGI Ref ID J:160990]

Wang C; McDonough JS; McDonald KG; Huang C; Newberry RD. 2008. Alpha4beta7/MAdCAM-1 interactions play an essential role in transitioning cryptopatches into isolated lymphoid follicles and a nonessential role in cryptopatch formation. J Immunol 181(6):4052-61. [PubMed: 18768861]  [MGI Ref ID J:139096]

Yamada D; Kadono T; Masui Y; Yanaba K; Sato S. 2014. beta7 Integrin controls mast cell recruitment, whereas alphaE integrin modulates the number and function of CD8+ T cells in immune complex-mediated tissue injury. J Immunol 192(9):4112-21. [PubMed: 24670804]  [MGI Ref ID J:209980]

Selltm1Tft related

Anderson BE; Taylor PA; McNiff JM; Jain D; Demetris AJ; Panoskaltsis-Mortari A; Ager A; Blazar BR; Shlomchik WD; Shlomchik MJ. 2008. Effects of donor T-cell trafficking and priming site on graft-versus-host disease induction by naive and memory phenotype CD4 T cells. Blood 111(10):5242-51. [PubMed: 18285547]  [MGI Ref ID J:135662]

Arbones ML; Ord DC; Ley K; Ratech H; Maynard-Curry C; Otten G; Capon DJ; Tedder TF. 1994. Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice. Immunity 1(4):247-60. [PubMed: 7534203]  [MGI Ref ID J:25005]

Bae SJ; Shimizu K; Yozaki M; Yamaoka T; Akiyama Y; Yoshizaki A; Muroi E; Hara T; Ogawa F; Sato S. 2010. Involvement of L-selectin in contact hypersensitivity responses augmented by auditory stress. Am J Pathol 176(1):187-97. [PubMed: 19948832]  [MGI Ref ID J:156378]

Diacovo TG; Blasius AL; Mak TW; Cella M; Colonna M. 2005. Adhesive mechanisms governing interferon-producing cell recruitment into lymph nodes. J Exp Med 202(5):687-96. [PubMed: 16147979]  [MGI Ref ID J:100718]

Doyle NA; Bhagwan SD; Meek BB; Kutkoski GJ; Steeber DA; Tedder TF; Doerschuk CM. 1997. Neutrophil margination, sequestration, and emigration in the lungs of L-selectin-deficient mice. J Clin Invest 99(3):526-33. [PubMed: 9022088]  [MGI Ref ID J:39042]

Forbes E; Hulett M; Ahrens R; Wagner N; Smart V; Matthaei KI; Brandt EB; Dent LA; Rothenberg ME; Tang M; Foster PS; Hogan SP. 2006. ICAM-1-dependent pathways regulate colonic eosinophilic inflammation. J Leukoc Biol 80(2):330-41. [PubMed: 16731772]  [MGI Ref ID J:111227]

Forlow SB; Ley K. 2001. Selectin-independent leukocyte rolling and adhesion in mice deficient in E-, P-, and L-selectin and ICAM-1. Am J Physiol Heart Circ Physiol 280(2):H634-41. [PubMed: 11158961]  [MGI Ref ID J:68044]

Friedline RH; Wong CP; Steeber DA; Tedder TF; Tisch R. 2002. L-selectin is not required for T cell-mediated autoimmune diabetes. J Immunol 168(6):2659-66. [PubMed: 11884430]  [MGI Ref ID J:126855]

Galkina E; Florey O; Zarbock A; Smith BR; Preece G; Lawrence MB; Haskard DO; Ager A. 2007. T lymphocyte rolling and recruitment into peripheral lymph nodes is regulated by a saturable density of L-selectin (CD62L). Eur J Immunol 37(5):1243-53. [PubMed: 17429841]  [MGI Ref ID J:123557]

Galkina E; Kadl A; Sanders J; Varughese D; Sarembock IJ; Ley K. 2006. Lymphocyte recruitment into the aortic wall before and during development of atherosclerosis is partially L-selectin dependent. J Exp Med 203(5):1273-82. [PubMed: 16682495]  [MGI Ref ID J:124135]

Galkina E; Tanousis K; Preece G; Tolaini M; Kioussis D; Florey O; Haskard DO; Tedder TF; Ager A. 2003. L-selectin shedding does not regulate constitutive T cell trafficking but controls the migration pathways of antigen-activated T lymphocytes. J Exp Med 198(9):1323-35. [PubMed: 14597735]  [MGI Ref ID J:86473]

Hafezi-Moghadam A; Thomas KL; Prorock AJ; Huo Y; Ley K. 2001. L-selectin shedding regulates leukocyte recruitment. J Exp Med 193(7):863-72. [PubMed: 11283159]  [MGI Ref ID J:120579]

Hamaguchi Y; Nishizawa Y; Yasui M; Hasegawa M; Kaburagi Y; Komura K; Nagaoka T; Saito E; Shimada Y; Takehara K; Kadono T; Steeber DA; Tedder TF; Sato S. 2002. Intercellular adhesion molecule-1 and L-selectin regulate bleomycin-induced lung fibrosis. Am J Pathol 161(5):1607-18. [PubMed: 12414509]  [MGI Ref ID J:79905]

Hickey MJ; Forster M; Mitchell D; Kaur J; De Caigny C; Kubes P. 2000. L-Selectin facilitates emigration and extravascular locomotion of leukocytes during acute inflammatory responses In vivo J Immunol 165(12):7164-70. [PubMed: 11120848]  [MGI Ref ID J:66107]

Ishii T; Fujita T; Matsushita T; Yanaba K; Hasegawa M; Nakashima H; Ogawa F; Shimizu K; Takehara K; Tedder TF; Sato S; Fujimoto M. 2009. Establishment of experimental eosinophilic vasculitis by IgE-mediated cutaneous reverse passive arthus reaction. Am J Pathol 174(6):2225-33. [PubMed: 19389931]  [MGI Ref ID J:148778]

Jung U; Ley K. 1999. Mice lacking two or all three selectins demonstrate overlapping and distinct functions for each selectin. J Immunol 162(11):6755-62. [PubMed: 10352295]  [MGI Ref ID J:55032]

Jung U; Ramos CL; Bullard DC; Ley K. 1998. Gene-targeted mice reveal importance of L-selectin-dependent rolling for neutrophil adhesion. Am J Physiol 274(5 Pt 2):H1785-91. [PubMed: 9612391]  [MGI Ref ID J:47723]

Kaburagi Y; Hasegawa M; Nagaoka T; Shimada Y; Hamaguchi Y; Komura K; Saito E; Yanaba K; Takehara K; Kadono T; Steeber DA; Tedder TF; Sato S. 2002. The cutaneous reverse Arthus reaction requires intercellular adhesion molecule 1 and L-selectin expression. J Immunol 168(6):2970-8. [PubMed: 11884469]  [MGI Ref ID J:112251]

Kamata M; Tada Y; Mitsui A; Shibata S; Miyagaki T; Asano Y; Sugaya M; Kadono T; Sato S. 2013. ICAM-1 deficiency exacerbates sarcoid-like granulomatosis induced by Propionibacterium acnes through impaired IL-10 production by regulatory T cells. Am J Pathol 183(6):1731-9. [PubMed: 24103557]  [MGI Ref ID J:205994]

Kanwar S; Steeber DA; Tedder TF; Hickey MJ; Kubes P. 1999. Overlapping roles for L-selectin and P-selectin in antigen-induced immune responses in the microvasculature. J Immunol 162(5):2709-16. [PubMed: 10072515]  [MGI Ref ID J:111002]

Kawasuji A; Hasegawa M; Horikawa M; Fujita T; Matsushita Y; Matsushita T; Fujimoto M; Steeber DA; Tedder TF; Takehara K; Sato S. 2006. L-selectin and intercellular adhesion molecule-1 regulate the development of Concanavalin A-induced liver injury. J Leukoc Biol 79(4):696-705. [PubMed: 16461740]  [MGI Ref ID J:107551]

Komura K; Hasegawa M; Hamaguchi Y; Saito E; Kaburagi Y; Yanaba K; Kawara S; Takehara K; Seki M; Steeber DA; Tedder TF; Sato S. 2003. Ultraviolet light exposure suppresses contact hypersensitivity by abrogating endothelial intercellular adhesion molecule-1 up-regulation at the elicitation site. J Immunol 171(6):2855-62. [PubMed: 12960307]  [MGI Ref ID J:85377]

Komura K; Iwata Y; Ogawa F; Yoshizaki A; Yamaoka T; Akiyama Y; Hara T; Hasegawa M; Fujimoto M; Sato S. 2009. Low zone tolerance requires ICAM-1 expression to limit contact hypersensitivity elicitation. J Invest Dermatol 129(11):2661-7. [PubMed: 19536145]  [MGI Ref ID J:157133]

Kunkel EJ; Chomas JE; Ley K. 1998. Role of primary and secondary capture for leukocyte accumulation in vivo. Circ Res 82(1):30-8. [PubMed: 9440702]  [MGI Ref ID J:114235]

Kunkel EJ; Ramos CL; Steeber DA; Muller W; Wagner N; Tedder TF; Ley K. 1998. The roles of L-selectin, beta 7 integrins, and P-selectin in leukocyte rolling and adhesion in high endothelial venules of Peyer's patches. J Immunol 161(5):2449-56. [PubMed: 9725243]  [MGI Ref ID J:112049]

Matsushita Y; Hasegawa M; Matsushita T; Fujimoto M; Horikawa M; Fujita T; Kawasuji A; Ogawa F; Steeber DA; Tedder TF; Takehara K; Sato S. 2007. Intercellular adhesion molecule-1 deficiency attenuates the development of skin fibrosis in tight-skin mice. J Immunol 179(1):698-707. [PubMed: 17579093]  [MGI Ref ID J:143152]

Nagaoka T; Kaburagi Y; Hamaguchi Y; Hasegawa M; Takehara K; Steeber DA; Tedder TF; Sato S. 2000. Delayed wound healing in the absence of intercellular adhesion molecule-1 or L-selectin expression. Am J Pathol 157(1):237-47. [PubMed: 10880393]  [MGI Ref ID J:63135]

Nakano H; Yanagita M; Gunn MD. 2001. CD11c(+)B220(+)Gr-1(+) cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells. J Exp Med 194(8):1171-8. [PubMed: 11602645]  [MGI Ref ID J:118783]

Ogawa A; Yoshizaki A; Yanaba K; Ogawa F; Hara T; Muroi E; Takenaka M; Shimizu K; Hasegawa M; Fujimoto M; Tedder TF; Sato S. 2010. The differential role of L-selectin and ICAM-1 in Th1-type and Th2-type contact hypersensitivity. J Invest Dermatol 130(6):1558-70. [PubMed: 20182448]  [MGI Ref ID J:160092]

Ostanin DV; Furr KL; Pavlick KP; Gray L; Kevil CG; Shukla D; D'Souza D; Hoffman JM; Grisham MB. 2007. T cell-associated CD18 but not CD62L, ICAM-1, or PSGL-1 is required for the induction of chronic colitis. Am J Physiol Gastrointest Liver Physiol 292(6):G1706-14. [PubMed: 17332469]  [MGI Ref ID J:123696]

Patnode ML; Yu SY; Cheng CW; Ho MY; Tegesjo L; Sakuma K; Uchimura K; Khoo KH; Kannagi R; Rosen SD. 2013. KSGal6ST generates galactose-6-O-sulfate in high endothelial venules but does not contribute to L-selectin-dependent lymphocyte homing. Glycobiology 23(3):381-94. [PubMed: 23254996]  [MGI Ref ID J:204813]

Ridger VC; Hellewell PG; Norman KE. 2005. L- and P-selectins collaborate to support leukocyte rolling in vivo when high-affinity P-selectin-P-selectin glycoprotein ligand-1 interaction is inhibited. Am J Pathol 166(3):945-52. [PubMed: 15743805]  [MGI Ref ID J:96776]

Rosenzweig HL; Martin TM; Jann MM; Planck SR; Davey MP; Kobayashi K; Flavell RA; Rosenbaum JT. 2008. NOD2, the gene responsible for familial granulomatous uveitis, in a mouse model of uveitis. Invest Ophthalmol Vis Sci 49(4):1518-24. [PubMed: 18385071]  [MGI Ref ID J:136140]

Schuster K; Gadiot J; Andreesen R; Mackensen A; Gajewski TF; Blank C. 2009. Homeostatic proliferation of naive CD8(+) T cells depends on CD62L/L-selectin-mediated homing to peripheral LN. Eur J Immunol 39(11):2981-2990. [PubMed: 19658092]  [MGI Ref ID J:154207]

Shigeta A; Matsumoto M; Tedder TF; Lowe JB; Miyasaka M; Hirata T. 2008. An L-selectin ligand distinct from P-selectin glycoprotein ligand-1 is expressed on endothelial cells and promotes neutrophil rolling in inflammation. Blood 112(13):4915-23. [PubMed: 18818390]  [MGI Ref ID J:144251]

Shimada Y; Hasegawa M; Kaburagi Y; Hamaguchi Y; Komura K; Saito E; Takehara K; Steeber DA; Tedder TF; Sato S. 2003. L-selectin or ICAM-1 deficiency reduces an immediate-type hypersensitivity response by preventing mast cell recruitment in repeated elicitation of contact hypersensitivity. J Immunol 170(8):4325-34. [PubMed: 12682269]  [MGI Ref ID J:125436]

Shimizu K; Ogawa F; Hara T; Yoshizaki A; Muroi E; Yanaba K; Akiyama Y; Yamaoka T; Sato S. 2013. Exogenous application of hydrogen sulfide donor attenuates inflammatory reactions through the L-selectin-involved pathway in the cutaneous reverse passive Arthus reaction. J Leukoc Biol 93(4):573-84. [PubMed: 23381473]  [MGI Ref ID J:198849]

Sinclair LV; Finlay D; Feijoo C; Cornish GH; Gray A; Ager A; Okkenhaug K; Hagenbeek TJ; Spits H; Cantrell DA. 2008. Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking. Nat Immunol 9(5):513-21. [PubMed: 18391955]  [MGI Ref ID J:134510]

Smith ML; Olson TS; Ley K. 2004. CXCR2- and E-selectin-induced neutrophil arrest during inflammation in vivo. J Exp Med 200(7):935-9. [PubMed: 15466624]  [MGI Ref ID J:93946]

Stadtmann A; Germena G; Block H; Boras M; Rossaint J; Sundd P; Lefort C; Fisher CI; Buscher K; Gelschefarth B; Urzainqui A; Gerke V; Ley K; Zarbock A. 2013. The PSGL-1-L-selectin signaling complex regulates neutrophil adhesion under flow. J Exp Med 210(11):2171-80. [PubMed: 24127491]  [MGI Ref ID J:206535]

Steeber DA; Campbell MA; Basit A; Ley K; Tedder TF. 1998. Optimal selectin-mediated rolling of leukocytes during inflammation in vivo requires intercellular adhesion molecule-1 expression. Proc Natl Acad Sci U S A 95(13):7562-7. [PubMed: 9636189]  [MGI Ref ID J:48271]

Steeber DA; Green NE; Sato S; Tedder TF. 1996. Humoral immune responses in L-selectin-deficient mice. J Immunol 157(11):4899-907. [PubMed: 8943394]  [MGI Ref ID J:37490]

Steeber DA; Tang ML; Green NE; Zhang XQ; Sloane JE; Tedder TF. 1999. Leukocyte entry into sites of inflammation requires overlapping interactions between the L-selectin and ICAM-1 pathways. J Immunol 163(4):2176-86. [PubMed: 10438959]  [MGI Ref ID J:57424]

Steeber DA; Tang ML; Zhang XQ; Muller W; Wagner N; Tedder TF. 1998. Efficient lymphocyte migration across high endothelial venules of mouse Peyer's patches requires overlapping expression of L-selectin and beta7 integrin. J Immunol 161(12):6638-47. [PubMed: 9862692]  [MGI Ref ID J:112112]

Subramanian H; Grailer JJ; Ohlrich KC; Rymaszewski AL; Loppnow JJ; Kodera M; Conway RM; Steeber DA. 2012. Signaling through L-selectin mediates enhanced chemotaxis of lymphocyte subsets to secondary lymphoid tissue chemokine. J Immunol 188(7):3223-36. [PubMed: 22387549]  [MGI Ref ID J:183093]

Tang ML; Hale LP; Steeber DA; Tedder TF. 1997. L-selectin is involved in lymphocyte migration to sites of inflammation in the skin: delayed rejection of allografts in L-selectin-deficient mice. J Immunol 158(11):5191-9. [PubMed: 9164936]  [MGI Ref ID J:40629]

Tang ML; Steeber DA; Zhang XQ; Tedder TF. 1998. Intrinsic differences in L-selectin expression levels affect T and B lymphocyte subset-specific recirculation pathways. J Immunol 160(10):5113-21. [PubMed: 9590263]  [MGI Ref ID J:47480]

Tedder TF; Steeber DA; Pizcueta P. 1995. L-selectin-deficient mice have impaired leukocyte recruitment into inflammatory sites. J Exp Med 181(6):2259-64. [PubMed: 7539045]  [MGI Ref ID J:26621]

Tu L; Poe JC; Kadono T; Venturi GM; Bullard DC; Tedder TF; Steeber DA. 2002. A functional role for circulating mouse L-selectin in regulating leukocyte/endothelial cell interactions in vivo. J Immunol 169(4):2034-43. [PubMed: 12165530]  [MGI Ref ID J:120206]

Venturi GM; Conway RM; Steeber DA; Tedder TF. 2007. CD25+CD4+ regulatory T cell migration requires L-selectin expression: L-selectin transcriptional regulation balances constitutive receptor turnover. J Immunol 178(1):291-300. [PubMed: 17182566]  [MGI Ref ID J:141931]

Venturi GM; Tu L; Kadono T; Khan AI; Fujimoto Y; Oshel P; Bock CB; Miller AS; Albrecht RM; Kubes P; Steeber DA; Tedder TF. 2003. Leukocyte migration is regulated by L-selectin endoproteolytic release. Immunity 19(5):713-24. [PubMed: 14614858]  [MGI Ref ID J:142184]

Wagner N; Lohler J; Tedder TF; Rajewsky K; Muller W; Steeber DA. 1998. L-selectin and beta7 integrin synergistically mediate lymphocyte migration to mesenteric lymph nodes. Eur J Immunol 28(11):3832-9. [PubMed: 9842926]  [MGI Ref ID J:114211]

Wang L; Fuster M; Sriramarao P; Esko JD. 2005. Endothelial heparan sulfate deficiency impairs L-selectin- and chemokine-mediated neutrophil trafficking during inflammatory responses. Nat Immunol 6(9):902-10. [PubMed: 16056228]  [MGI Ref ID J:100456]

Yamada M; Yanaba K; Hasegawa M; Matsushita Y; Horikawa M; Komura K; Matsushita T; Kawasuji A; Fujita T; Takehara K; Steeber DA; Tedder TF; Sato S. 2006. Regulation of local and metastatic host-mediated anti-tumour mechanisms by L-selectin and intercellular adhesion molecule-1. Clin Exp Immunol 143(2):216-27. [PubMed: 16412045]  [MGI Ref ID J:108135]

Yoshizaki A; Yanaba K; Iwata Y; Komura K; Ogawa A; Akiyama Y; Muroi E; Hara T; Ogawa F; Takenaka M; Shimizu K; Hasegawa M; Fujimoto M; Tedder TF; Sato S. 2010. Cell Adhesion Molecules Regulate Fibrotic Process via Th1/Th2/Th17 Cell Balance in a Bleomycin-Induced Scleroderma Model. J Immunol 185(4):2502-15. [PubMed: 20624949]  [MGI Ref ID J:162381]

Yukami T; Hasegawa M; Matsushita Y; Fujita T; Matsushita T; Horikawa M; Komura K; Yanaba K; Hamaguchi Y; Nagaoka T; Ogawa F; Fujimoto M; Steeber DA; Tedder TF; Takehara K; Sato S. 2007. Endothelial selectins regulate skin wound healing in cooperation with L-selectin and ICAM-1. J Leukoc Biol 82(3):519-31. [PubMed: 17595378]  [MGI Ref ID J:124291]

Zhang S; Condac E; Qiu H; Jiang J; Gutierrez-Sanchez G; Bergmann C; Handel T; Wang L. 2012. Heparin-induced leukocytosis requires 6-O-sulfation and is caused by blockade of selectin- and CXCL12 protein-mediated leukocyte trafficking in mice. J Biol Chem 287(8):5542-53. [PubMed: 22194593]  [MGI Ref ID J:182444]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2525.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $1650.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3283.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $2145.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

General Supply Notes

Control Information

  Control
   001976 NOD/ShiLtJ
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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