Strain Name:

NOD.B6-Itgb7tm1Cgn/2LtJ

Stock Number:

004944

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Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names NOD.B6-Itgb7tm1Cgn/2Lt    (Changed: 12-JUL-05 )
Type Congenic; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
Background Strain NOD/ShiLt
Donor Strain C57BL/6
H2 Haplotypeg7
 
Donating InvestigatorDr. Edward Leiter,   The Jackson Laboratory

Appearance
albino
Related Genotype: A/A Tyrc/Tyrc

Description
Mice homozygous for the targeted mutation have a marked hypoplasia of the gut-associated lymphoid tissue(GALT). This deficit is apparently due to the failure of Itgb7 deficient lymphocytes to arrest and adhere in the GALT.

Development
This strain was derived from an initial cross between mice of strains NOD/Lt and C57BL/6-Itgb7tm1Cgn (Stock No. 002965), followed by 10 backcrosses (to N11) to NOD/Lt of progeny selected for heterozygosity for the targeted allele. Heterozygous offspring of the final backcross were intercrossed to initiate a line homozygous for Itgb7tm1Cgn, and the strain was then maintained by sibling inbreeding. Statistically, this strain's genome is approximately 99.95% of NOD/Lt origin. Marker assisted analysis of all known Idd loci (1-21) are of NOD origin. This stock was transferred from Ed Leiter's research colony into the T1DR via rederivation.

Control Information

  Control
   001976 NOD/ShiLtJ
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Itgb7tm1Cgn allele
002965   C57BL/6-Itgb7tm1Cgn/J
004943   NOD.Cg-Selltm1Tft Itgb7tm1Cgn/LtJ
View Strains carrying   Itgb7tm1Cgn     (2 strains)

Strains carrying other alleles of Itgb7
007707   C57BL/6-Itgb7tm1Mshi/J
View Strains carrying other alleles of Itgb7     (1 strain)

Phenotype

Phenotype Information

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Itgb7tm1Cgn related

Cell Biology Research
Defects in Cell Adhesion Molecules

Immunology, Inflammation and Autoimmunity Research
Growth Factors/Receptors/Cytokines
Lymphoid Tissue Defects

Currently there is no phenotype information for this strain.

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Itgb7tm1Cgn
Allele Name targeted mutation 1, University of Cologne
Allele Type Targeted (Null/Knockout)
Common Name(s) Itgbtm1Ctg; beta7-;
Mutation Made By Norbert Wagner,   University of Cologne
Strain of OriginC57BL/6J
ES Cell Line NameBL/6-III
ES Cell Line StrainC57BL/6J
Gene Symbol and Name Itgb7, integrin beta 7
Chromosome 15
Molecular Note A neomycin resistance cassette replaced part of exon 12 and all of exons 13 and 14, which encode the transmembrane and part of the extracellular domains. [MGI Ref ID J:34306]

Genotyping

Genotyping Information

Genotyping Protocols

Itgb7tm1Cgn, High Resolution Melting
Itgb7tm1Cgn, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Wagner N; Lohler J; Kunkel EJ; Ley K; Leung E; Krissansen G; Rajewsky K; Muller W. 1996. Critical role for beta7 integrins in formation of the gut-associated lymphoid tissue. Nature 382(6589):366-70. [PubMed: 8684468]  [MGI Ref ID J:34306]

Additional References

Itgb7tm1Cgn related

Abonia JP; Hallgren J; Jones T; Shi T; Xu Y; Koni P; Flavell RA; Boyce JA; Austen KF; Gurish MF. 2006. Alpha-4 integrins and VCAM-1, but not MAdCAM-1, are essential for recruitment of mast cell progenitors to the inflamed lung. Blood 108(5):1588-94. [PubMed: 16670268]  [MGI Ref ID J:138072]

Agnello D; Denimal D; Lavaux A; Blondeau-Germe L; Lu B; Gerard NP; Gerard C; Pothier P. 2013. Intrarectal immunization and IgA antibody-secreting cell homing to the small intestine. J Immunol 190(9):4836-47. [PubMed: 23547118]  [MGI Ref ID J:195497]

Apostolaki M; Manoloukos M; Roulis M; Wurbel MA; Muller W; Papadakis KA; Kontoyiannis DL; Malissen B; Kollias G. 2008. Role of beta7 integrin and the chemokine/chemokine receptor pair CCL25/CCR9 in modeled TNF-dependent Crohn's disease. Gastroenterology 134(7):2025-35. [PubMed: 18439426]  [MGI Ref ID J:136667]

Artis D; Humphreys NE; Potten CS; Wagner N; Muller W; McDermott JR; Grencis RK; Else KJ. 2000. Beta7 integrin-deficient mice: delayed leukocyte recruitment and attenuated protective immunity in the small intestine during enteric helminth infection Eur J Immunol 30(6):1656-64. [PubMed: 10898502]  [MGI Ref ID J:62733]

Berberich S; Dahne S; Schippers A; Peters T; Muller W; Kremmer E; Forster R; Pabst O. 2008. Differential molecular and anatomical basis for B cell migration into the peritoneal cavity and omental milky spots. J Immunol 180(4):2196-203. [PubMed: 18250426]  [MGI Ref ID J:132002]

Bry L; Brenner MB. 2004. Critical role of T cell-dependent serum antibody, but not the gut-associated lymphoid tissue, for surviving acute mucosal infection with Citrobacter rodentium, an attaching and effacing pathogen. J Immunol 172(1):433-41. [PubMed: 14688352]  [MGI Ref ID J:87077]

Collins CB; Ho J; Wilson TE; Wermers JD; Tlaxca JL; Lawrence MB; Solga M; Lannigan J; Rivera-Nieves J. 2008. CD44 deficiency attenuates chronic murine ileitis. Gastroenterology 135(6):1993-2002. [PubMed: 18854186]  [MGI Ref ID J:145626]

Croy BA; Ashkar AA; Foster RA; DiSanto JP; Magram J; Carson D; Gendler SJ; Grusby MJ; Wagner N; Muller W; Guimond MJ. 1997. Histological studies of gene-ablated mice support important functional roles for natural killer cells in the uterus during pregnancy J Reprod Immunol 35(2):111-33. [PubMed: 9421796]  [MGI Ref ID J:44813]

Czarneski J; Berguer P; Bekinschtein P; Kim DC; Hakimpour P; Wagner N; Nepomnaschy I; Piazzon I; Ross SR. 2002. Neonatal infection with a milk-borne virus is independent of beta7 integrin- and L-selectin-expressing lymphocytes. Eur J Immunol 32(4):945-56. [PubMed: 11920560]  [MGI Ref ID J:76001]

DeNucci CC; Pagan AJ; Mitchell JS; Shimizu Y. 2010. Control of alpha4beta7 integrin expression and CD4 T cell homing by the beta1 integrin subunit. J Immunol 184(5):2458-67. [PubMed: 20118278]  [MGI Ref ID J:159655]

Denucci CC; Shimizu Y. 2011. {beta}1 Integrin Is Critical for the Maintenance of Antigen-Specific CD4 T Cells in the Bone Marrow but Not Long-Term Immunological Memory. J Immunol 186(7):4019-26. [PubMed: 21357540]  [MGI Ref ID J:170691]

Dutt S; Ermann J; Tseng D; Liu YP; George TI; Fathman CG; Strober S. 2005. L-selectin and beta7 integrin on donor CD4 T cells are required for the early migration to host mesenteric lymph nodes and acute colitis of graft-versus-host disease. Blood 106(12):4009-15. [PubMed: 16105972]  [MGI Ref ID J:124067]

Fernekorn U; Butcher EC; Behrends J; Hartz S; Kruse A. 2004. Functional involvement of P-selectin and MAdCAM-1 in the recruitment of alpha4beta7-integrin-expressing monocyte-like cells to the pregnant mouse uterus. Eur J Immunol 34(12):3423-33. [PubMed: 15484189]  [MGI Ref ID J:94597]

Forbes E; Hulett M; Ahrens R; Wagner N; Smart V; Matthaei KI; Brandt EB; Dent LA; Rothenberg ME; Tang M; Foster PS; Hogan SP. 2006. ICAM-1-dependent pathways regulate colonic eosinophilic inflammation. J Leukoc Biol 80(2):330-41. [PubMed: 16731772]  [MGI Ref ID J:111227]

Ghosh S; Chackerian AA; Parker CM; Ballantyne CM; Behar SM. 2006. The LFA-1 adhesion molecule is required for protective immunity during pulmonary Mycobacterium tuberculosis infection. J Immunol 176(8):4914-22. [PubMed: 16585587]  [MGI Ref ID J:131154]

Gorfu G; Rivera-Nieves J; Hoang S; Abbott DW; Arbenz-Smith K; Azar DW; Pizarro TT; Cominelli F; McDuffie M; Ley K. 2010. Beta7 integrin deficiency suppresses B cell homing and attenuates chronic ileitis in SAMP1/YitFc mice. J Immunol 185(9):5561-8. [PubMed: 20926792]  [MGI Ref ID J:165177]

Gurish MF; Tao H; Abonia JP; Arya A; Friend DS; Parker CM; Austen KF. 2001. Intestinal mast cell progenitors require CD49dbeta7 (alpha4beta7 integrin) for tissue-specific homing. J Exp Med 194(9):1243-52. [PubMed: 11696590]  [MGI Ref ID J:119138]

Hadis U; Wahl B; Schulz O; Hardtke-Wolenski M; Schippers A; Wagner N; Muller W; Sparwasser T; Forster R; Pabst O. 2011. Intestinal Tolerance Requires Gut Homing and Expansion of FoxP3(+) Regulatory T Cells in the Lamina Propria. Immunity 34(2):237-46. [PubMed: 21333554]  [MGI Ref ID J:168976]

Ho J; Kurtz CC; Naganuma M; Ernst PB; Cominelli F; Rivera-Nieves J. 2008. A CD8+/CD103high T cell subset regulates TNF-mediated chronic murine ileitis. J Immunol 180(4):2573-80. [PubMed: 18250468]  [MGI Ref ID J:131978]

Karsten CM; Behrends J; Wagner AK; Fuchs F; Figge J; Schmudde I; Hellberg L; Kruse A. 2009. DC within the pregnant mouse uterus influence growth and functional properties of uterine NK cells. Eur J Immunol 39(8):2203-14. [PubMed: 19593769]  [MGI Ref ID J:151694]

Kuklin NA; Rott L; Feng N; Conner ME; Wagner N; Muller W; Greenberg HB. 2001. Protective intestinal anti-rotavirus B cell immunity is dependent on alpha(4)beta(7) integrin expression but does not require IgA antibody production. J Immunol 166(3):1894-902. [PubMed: 11160237]  [MGI Ref ID J:67098]

Kunkel EJ; Ramos CL; Steeber DA; Muller W; Wagner N; Tedder TF; Ley K. 1998. The roles of L-selectin, beta 7 integrins, and P-selectin in leukocyte rolling and adhesion in high endothelial venules of Peyer's patches. J Immunol 161(5):2449-56. [PubMed: 9725243]  [MGI Ref ID J:112049]

Lammermann T; Bader BL; Monkley SJ; Worbs T; Wedlich-Soldner R; Hirsch K; Keller M; Forster R; Critchley DR; Fassler R; Sixt M. 2008. Rapid leukocyte migration by integrin-independent flowing and squeezing. Nature 453(7191):51-5. [PubMed: 18451854]  [MGI Ref ID J:134784]

Mancassola R; Lacroix-Lamande S; Barrier M; Naciri M; Salmon H; Laurent F. 2004. Increased susceptibility of beta7-integrin-deficient neonatal mice in the early stage of Cryptosporidium parvum infection. Infect Immun 72(6):3634-7. [PubMed: 15155674]  [MGI Ref ID J:90262]

Park EJ; Mora JR; Carman CV; Chen J; Sasaki Y; Cheng G; von Andrian UH; Shimaoka M. 2007. Aberrant activation of integrin alpha4beta7 suppresses lymphocyte migration to the gut. J Clin Invest 117(9):2526-38. [PubMed: 17786243]  [MGI Ref ID J:127413]

Quast T; Tappertzhofen B; Schild C; Grell J; Czeloth N; Forster R; Alon R; Fraemohs L; Dreck K; Weber C; Lammermann T; Sixt M; Kolanus W. 2009. Cytohesin-1 controls the activation of RhoA and modulates integrin-dependent adhesion and migration of dendritic cells. Blood 113(23):5801-10. [PubMed: 19346499]  [MGI Ref ID J:149500]

Schippers A; Kochut A; Pabst O; Frischmann U; Clahsen T; Tenbrock K; Muller W; Wagner N. 2012. beta7 integrin controls immunogenic and tolerogenic mucosal B cell responses. Clin Immunol 144(2):87-97. [PubMed: 22710445]  [MGI Ref ID J:188011]

Steeber DA; Tang ML; Zhang XQ; Muller W; Wagner N; Tedder TF. 1998. Efficient lymphocyte migration across high endothelial venules of mouse Peyer's patches requires overlapping expression of L-selectin and beta7 integrin. J Immunol 161(12):6638-47. [PubMed: 9862692]  [MGI Ref ID J:112112]

Sydora BC; Wagner N; Lohler J; Yakoub G; Kronenberg M; Muller W; Aranda R. 2002. beta7 Integrin expression is not required for the localization of T cells to the intestine and colitis pathogenesis. Clin Exp Immunol 129(1):35-42. [PubMed: 12100020]  [MGI Ref ID J:115570]

Tu L; Poe JC; Kadono T; Venturi GM; Bullard DC; Tedder TF; Steeber DA. 2002. A functional role for circulating mouse L-selectin in regulating leukocyte/endothelial cell interactions in vivo. J Immunol 169(4):2034-43. [PubMed: 12165530]  [MGI Ref ID J:120206]

Wagner N; Lohler J; Tedder TF; Rajewsky K; Muller W; Steeber DA. 1998. L-selectin and beta7 integrin synergistically mediate lymphocyte migration to mesenteric lymph nodes. Eur J Immunol 28(11):3832-9. [PubMed: 9842926]  [MGI Ref ID J:114211]

Waldman E; Lu SX; Hubbard VM; Kochman AA; Eng JM; Terwey TH; Muriglan SJ; Kim TD; Heller G; Murphy GF; Liu C; Alpdogan O; van den Brink MR. 2006. Absence of beta7 integrin results in less graft-versus-host disease because of decreased homing of alloreactive T cells to intestine. Blood 107(4):1703-11. [PubMed: 16291587]  [MGI Ref ID J:129395]

Wang C; Kang SG; HogenEsch H; Love PE; Kim CH. 2010. Retinoic acid determines the precise tissue tropism of inflammatory Th17 cells in the intestine. J Immunol 184(10):5519-26. [PubMed: 20400707]  [MGI Ref ID J:160990]

Wang C; McDonough JS; McDonald KG; Huang C; Newberry RD. 2008. Alpha4beta7/MAdCAM-1 interactions play an essential role in transitioning cryptopatches into isolated lymphoid follicles and a nonessential role in cryptopatch formation. J Immunol 181(6):4052-61. [PubMed: 18768861]  [MGI Ref ID J:139096]

Yamada D; Kadono T; Masui Y; Yanaba K; Sato S. 2014. beta7 Integrin controls mast cell recruitment, whereas alphaE integrin modulates the number and function of CD8+ T cells in immune complex-mediated tissue injury. J Immunol 192(9):4112-21. [PubMed: 24670804]  [MGI Ref ID J:209980]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2525.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $1650.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3283.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $2145.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

General Supply Notes

Control Information

  Control
   001976 NOD/ShiLtJ
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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