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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Former Names C3HeB/FeJ-Cacnb4lh-3J/J (Changed: 22-JUN-09 ) Type Coisogenic; Mutant Strain; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation F6+N1p (15-JAN-06)
Generation DefinitionsImportant Note
This strain is homozygous for the retinal degeneration allele Pde6brd1.Description
Mice homozygous for lethargic 3 Jackson are recognizable at 14 days of age. They exhibit a behavior characteristic of lethargic with a wobbly gait resembling an unsteady wide legged shuffle. Some Cacnb4lh-3J homozygotes also have a stargazing phenotype, but seizures have not been reported. The homozygotes are smaller than their wildtype littermates but live a normal lifespan. Both sexes may breed but they produce smaller litters or stop breeding earlier than heterozygous sibs.Development
The lethargic 3 Jackson mutation arose spontaneously in the C3HeB/FeJ colony at The Jackson Laboratory in the Spring of 2001 when that colony was at F182. After one backcross to C3HeB/FeJ, the strain was maintained by sibling mating, primarily homozygous female x heterozygous male since homozygous males do not tend to breed. In 2004 this strain reached F182+N1F6.
Control Information
| Control | ||
|---|---|---|
| Heterozygote from the colony | ||
| 000658 C3HeB/FeJ | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of Cacnb4
000504 B6EiC3Sn a/A-Cacnb4lh/J 008626 STOCK Cacnb4lh-2J/LetJ View Strains carrying other alleles of Cacnb4 (2 strains)
Phenotype
Phenotype Information
assigned by genotype
Cacnb4lh-3J/Cacnb4lh-3J
C3HeB/FeJ
- behavior/neurological phenotype
- abnormal head movements (MGI Ref ID J:88414)
- abnormal locomotor behavior (MGI Ref ID J:88414)
- abnormal gait
- lethargy
- some lh-3J mice also have a stargazing phenotype, where their heads frequently point upwards, but seizures have not been reported (MGI Ref ID J:88414)
- growth/size phenotype
- decreased body size
- homozygotes are smaller than their littermates but live a nornal lifespan (MGI Ref ID J:88414)
This mouse can be used to support research in many areas including:Cacnb4lh-3J related
Cell Biology Research
Channel and Transporter Defects
calcium
Neurobiology Research
Ataxia (Movement) Defects
Channel and Transporter Defects
calcium
Epilepsy
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Cacnb4lh-3J | ||
|---|---|---|---|
| Allele Name | lethargic 3 Jackson | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | C3HeB/FeJ | ||
| Gene Symbol and Name | Cacnb4, calcium channel, voltage-dependent, beta 4 subunit | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | 3110038O15Rik; CAB4; CACNLB4; Cchb4; EA5; EIG9; EJM; EJM4; EJM6; RIKEN cDNA 3110038O15 gene; calcium channel, B4 subunit; lethargic; lh; | ||
| Molecular Note | The allelic nature of this mouse to this locus was determined by complementation analysis with the original lh mouse. [MGI Ref ID J:88414] | ||
References
References provided by MGI
Selected Reference(s)
Samples RM; Ward-Bailey P; Donahue LR; Bronson RT; Davisson MT. 2004. Lethargic 3 Jackson, a remutation of the Cacnb4 gene on mouse Chromosome 2. Mouse Mutant Resource Web Site, The Jackson Laboratory, Bar Harbor, Maine. World Wide Web MGI Direct Data Submission :. [MGI Ref ID J:88414]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, RG10/RG30.
Purchasing information
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $1980.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Embryos
Price (US dollars $) Frozen Embryo $1600.00 Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
Supply Notes
- Cryopreserved Embryos
Available to most shipping destinations1
This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.
1 Shipments cannot be made to Australia due to Australian government import restrictions.
2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.- Cryorecovery - Standard.
We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
| Pricing for International shipping destinations |
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Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $2574.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Embryos
Price (US dollars $) Frozen Embryo $2080.00 Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
Supply Notes
- Cryopreserved Embryos
Available to most shipping destinations1
This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.
1 Shipments cannot be made to Australia due to Australian government import restrictions.
2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.- Cryorecovery - Standard.
We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
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Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
General Supply Notes
- This strain is included in the Mouse Mutant Resource collection.
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| Heterozygote from the colony | ||
| 000658 C3HeB/FeJ | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Important Note
This strain is homozygous for the retinal degeneration allele Pde6brd1.
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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Tel: 1-800-422-6423 or 1-207-288-5845
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| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
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