Strain Name:

C3H/HeJ-Clic5jbg/J

Stock Number:

004965

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Availability:

Cryopreserved - Ready for recovery

Other products are available, see Purchasing Information for Cryopreserved Embryos

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names C3H/HeJ-Clic5jbg    (Changed: 18-OCT-06 )
C3H/HeJ-jbg    (Changed: 18-OCT-06 )
Type Coisogenic; Mutant Strain; Spontaneous Mutation;
Additional information on Genetically Engineered and Mutant Mice.
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Specieslaboratory mouse

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Deafness, Autosomal Recessive 103; DFNB103   (CLIC5)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Clic5jbg/Clic5jbg

        C3H/HeJ-Clic5jbg/J
  • hearing/vestibular/ear phenotype
  • abnormal cochlear hair cell stereociliary bundle morphology
    • at 3 days of age hair bundle orientation, patterning, and morphology appear nearly normal but by 15 days of age abnormal and missing stereocilia are commonly observed in hair cells throughout the cochlear duct and progressive degeneration of hair cells is found with diminished numbers in the crista ampullaris by 3 months of age and nearly absent by 12 months of age   (MGI Ref ID J:112741)
  • cochlear inner hair cell degeneration
    • outer hair cells degenerate before innner hair cells   (MGI Ref ID J:112741)
  • cochlear outer hair cell degeneration
    • outer hair cells degenerate before innner hair cells   (MGI Ref ID J:112741)
  • deafness
    • hearing loss leads to deafness by 7 months of age   (MGI Ref ID J:112741)
  • increased or absent threshold for auditory brainstem response
    • at 1 to 5 months of age homozygotes have an ABR threshold of 40-50 dB above wildtype controls   (MGI Ref ID J:112741)
    • by 7 months of age, mutants show no evoked response to the highest auditory stimuli presented   (MGI Ref ID J:112741)
  • organ of Corti degeneration
    • severe degeneration by 12 months of age   (MGI Ref ID J:112741)
    • Reissner's membrane and stria vascularis remain intact despite degeneration in the inner ear   (MGI Ref ID J:112741)
  • vestibular hair cell degeneration
    • progressive degeneration of vestibular hair cells   (MGI Ref ID J:112741)
    • in the crista ampullaris, vestibular hair cells are markedly reduced in number at 3 months and nearly absent at 12 months of age   (MGI Ref ID J:112741)
  • behavior/neurological phenotype
  • bidirectional circling   (MGI Ref ID J:112741)
  • head bobbing   (MGI Ref ID J:112741)
  • impaired swimming
    • homozygotes fail to orient in water   (MGI Ref ID J:112741)
  • nervous system phenotype
  • abnormal cochlear hair cell stereociliary bundle morphology
    • at 3 days of age hair bundle orientation, patterning, and morphology appear nearly normal but by 15 days of age abnormal and missing stereocilia are commonly observed in hair cells throughout the cochlear duct and progressive degeneration of hair cells is found with diminished numbers in the crista ampullaris by 3 months of age and nearly absent by 12 months of age   (MGI Ref ID J:112741)
  • cochlear ganglion degeneration
    • density of spiral ganglion cells is diminished in the cochlea by 12 months of age   (MGI Ref ID J:112741)
  • cochlear inner hair cell degeneration
    • outer hair cells degenerate before innner hair cells   (MGI Ref ID J:112741)
  • cochlear outer hair cell degeneration
    • outer hair cells degenerate before innner hair cells   (MGI Ref ID J:112741)
  • vestibular hair cell degeneration
    • progressive degeneration of vestibular hair cells   (MGI Ref ID J:112741)
    • in the crista ampullaris, vestibular hair cells are markedly reduced in number at 3 months and nearly absent at 12 months of age   (MGI Ref ID J:112741)
  • respiratory system phenotype
  • abnormal pulmonary alveolus morphology
    • progressive enlargement of alveolar air spaces   (MGI Ref ID J:112741)

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Clic5jbg
Allele Name jitterbug
Allele Type Spontaneous
Strain of OriginC3H/HeJ
Gene Symbol and Name Clic5, chloride intracellular channel 5
Chromosome 17
Gene Common Name(s) 5730531E12Rik; DFNB102; DFNB103; MST130; MSTP130; RIKEN cDNA 5730531E12 gene; jbg; jitterbug;
Molecular Note A 97 base pair deletion, including the 3'-most 87 base pairs of exon 5 and 10 base pairs of the flanking intron sequence including the exon/intron splice donor recognition sequence, results in a frame shift and premature stop codon in both Clic5A and Clic5B transcripts, effectively resulting in a null mutation of both transcripts. [MGI Ref ID J:112741]

Genotyping

Genotyping Information

Genotyping Protocols

Clic5jbg, High Resolution Melting


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Gagnon LH; Longo-Guess CM; Berryman M; Shin JB; Saylor KW; Yu H; Gillespie PG; Johnson KR. 2006. The chloride intracellular channel protein CLIC5 is expressed at high levels in hair cell stereocilia and is essential for normal inner ear function. J Neurosci 26(40):10188-98. [PubMed: 17021174]  [MGI Ref ID J:112741]

Additional References

Clic5jbg related

Bradford EM; Miller ML; Prasad V; Nieman ML; Gawenis LR; Berryman M; Lorenz JN; Tso P; Shull GE. 2010. CLIC5 mutant mice are resistant to diet-induced obesity and exhibit gastric hemorrhaging and increased susceptibility to torpor. Am J Physiol Regul Integr Comp Physiol 298(6):R1531-42. [PubMed: 20357015]  [MGI Ref ID J:160186]

Pierchala BA; Munoz MR; Tsui CC. 2010. Proteomic analysis of the slit diaphragm complex: CLIC5 is a protein critical for podocyte morphology and function. Kidney Int 78(9):868-82. [PubMed: 20664558]  [MGI Ref ID J:184254]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2525.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $1650.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3283.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $2145.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

General Supply Notes

  • View the complete collection of spontaneous mutants in the Mouse Mutant Resource.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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