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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Former Names NOD/ShiLtDvs-Tg(Ins2-E3*734)3Dvs (Changed: 07-MAR-07 ) NOD/LtDvs-Tg(Ins2-E3*734)3Dvs (Changed: 23-FEB-07 ) NOD/LtDvs-Tg(RIP E3-734)3Dvs (Changed: 03-APR-06 ) Type Mutant Strain; Transgenic; Additional information on Genetically Engineered Mutant Mice. Species laboratory mouse Appearance
albino
Related Genotype: A/A Tyrc/TyrcDescription
Carriers of this transgene express the transcripts of the adenoviral E3 19K, 11.6K, 14.5K, 14.7K, and 10.4K glycoproteins in the islets but the adenovirus death protein is not expressed due to point mutations in the first two methionines of the 11.6K open reading frame. Female carriers of this transgene have slower kinetics and rates of development of diabetes through 30 weeks of age relative to NOD/Lt controls. These carriers do not display a significantly different diabetes rate than un-mutated adenovirus E3 carriers.
Related Strains
Strains carrying other alleles of Ins2
View Strains carrying other alleles of Ins2 (45 strains)
Phenotype
Phenotype Information
assigned by genotype
Tg(Ins2-E3*734)3Dvs/0
NOD/ShiLtDvs-Tg(Ins2-E3*734)3Dvs/DvsJ
- immune system phenotype
- decreased susceptibility to autoimmune diabetes (MGI Ref ID J:106340)
- female carriers of this transgene have slower kinetics and rates of development of diabetes through 30 weeks of age relative to NOD controls and these transgene carriers do not display a significantly different diabetes rate than unmutated adenovirus E3 carriers
This mouse can be used to support research in many areas including:
Diabetes and Obesity Research
Type 1 Diabetes (IDDM) (resistant)
Type 1 Diabetes (IDDM) Analysis Strains (NOD Transgenics)
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Tg(Ins2-E3*734)3Dvs | ||
|---|---|---|---|
| Allele Name | transgene insertion 3, David V Serreze | ||
| Allele Type | Transgenic (random, expressed) | ||
| Common Name(s) | DL734; RIP-DL734; Tg(RIP-E3-734)3Dvs; | ||
| Mutation Made By | David Serreze, The Jackson Laboratory | ||
| Expressed Gene | E3, adenovirus early region 3, adenovirus | ||
| Promoter | Ins2, insulin 2, rat | ||
| Molecular Note | The rat insulin promoter was placed upstream of the adenovirus early reagion 3 (E3) sequences with two point mutations in the first two methionines of the 11.6K open reading frame and this construct was injected into NOD/LtDvs oocytes [MGI Ref ID J:106340] | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Optimizing PCR Protocols
References
References
Selected Reference(s)
Pierce MA; Svetlanov A; Horwitz MS; Serreze DV. 2005. Adenovirus early region 3 transgenes expressed in beta cells prevent autoimmune diabetes in nonobese diabetic mice: effects of deleting the adenovirus death protein 11.6K. J Virol 79(1):619-21. [PubMed: 15596856] [MGI Ref ID J:106340]
Health & husbandry
Health & Colony Maintenance Information
Currently there no information available for this strain. This may be due to the supply level of this strain.
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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*Price(s) in US dollars ($)
Weeks of Age Price* Gender Cryorecovery Fee $1900.00
Additional Supply Details
| Pricing for International shipping destinations |
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*Price(s) in US dollars ($)
Weeks of Age Price* Gender Cryorecovery Fee $2470.00
Additional Supply Details
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
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| Supply Notes |
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General Terms and Conditions
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