Strain Name:

B6.Cg-Tg(DBH-Gal)1923Stei/J

Stock Number:

004996

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Availability:

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Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Congenic; Mutant Strain; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
 
Donating Investigator Robert A. Steiner,   University of Washington, Box 357290

Description
These transgenic mice overexpress the mouse galanin protein under the direction of the human dopamine beta-hydroxylase promoter. Mice that are homozygous for the transgene are viable, normal in size and do not display any gross physical or behavioral abnormalities. In situ hybridization analysis of brain detects a 5-fold increase in galanin mRNA levels in the locus coeruleus region. Radioimmunoassay reveals a 2-fold increase in gene product peptide level in the forebrain. An increase of galanin-like immunoreactive staining and fiber density is also detected. The number of basal forebrain cholinergic neurons is decreased. Transgenic mice have impaired learning and memory as assessed by the Morris spatial navigational test and the social transmission of food preference test. Resistance to seizures induced by perforant path stimulation or administration of kainic acid is increased. Mutant mice exhibit increased afterdischarge (AD) induction threshold and diminished glutamate release after depolarization. Treatment with M35, a galanin receptor antagonist, rescues abnormal seizure response. Perforant path-dentate gyrus long-term potentiation is impaired. This mutant mouse strain represents a model that may be useful in studies of Alzheimer's disease and epileptic seizures.

Development
A transgenic construct containing a 5.8 Kb sequence of human dopamine beta-hydroxylase promoter, and a 4.6 Kb sequence of the mouse galanin gene was injected into fertilized SJL X C57BL/6 mouse eggs. The resulting male transgenic mice were backcrossed for 7 generations on the C57BL/6J background.

Control Information

  Control
   Noncarrier
   000664 C57BL/6J
 
  Considerations for Choosing Controls

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View Alzheimer's Disease Models     (109 strains)

View Strains carrying other alleles of DBH     (3 strains)

Additional Web Information

Visit the Alzheimer's Disease Mouse Model Resource site for helpful information on Alzheimer's Disease and research resources.

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Tg(DBH-Gal)1923Stei/0

        B6.Cg-Tg(DBH-Gal)1923Stei
  • mortality/aging
  • decreased sensitivity to xenobiotic induced morbidity/mortality
    • 1/6 mice die after 30 mg/kg kainic acid treatment compared to 5/6 wild-type mice   (MGI Ref ID J:77625)
  • behavior/neurological phenotype
  • abnormal olfactory -discrimination memory
    • transgenic mice show no preference for a previously cued food odor 24 hours after exposure, whereas wild-type show significant preference for cued food odor   (MGI Ref ID J:102197)
  • abnormal spatial learning
    • mice show significant impairment compared to controls, failing to display selective search during the probe trial when the platform is removed in the Morris water maze; controls show greater preference for the target quadrant at 8 and 16 months   (MGI Ref ID J:102197)
    • mutants have normal performance in the visible and hidden platform trials, but show inability to remember navigational cues needed to solve spatial navigation problem   (MGI Ref ID J:102197)
  • seizures
    • after 60 minutes of perforant path stimulation, only brief seizure activity is seen in transgenic mice compared to wild-type controls; last seizure occurs 25 minutes after PPS   (MGI Ref ID J:77625)
    • decreased susceptibility to pharmacologically induced seizures
      • 30 mg/kg kainic acid treatment induces a few stage 5 seizures, resulting in death of 1/6 animals, but wild-type animals exhibit severe seizures, with death occurring in 5/6 animals within 30 minutes   (MGI Ref ID J:77625)
      • pentylene tetrazol (PTZ) treatment results in less severe seizures than those induced by kainic acid   (MGI Ref ID J:77625)
      • galanin agonist treatment reduces the latency and severity of PTZ-induced seizures   (MGI Ref ID J:77625)
  • nervous system phenotype
  • abnormal cholinergic neuron morphology
    • disappearance of detectable cholinergic neurons is observed   (MGI Ref ID J:102197)
  • abnormal hippocampus morphology
    • after kainic acid treatment, the surviving transgenic mice display mild injury to the hippocampus, compared to the wild-type survivor which displayed moderate injury in the CA1, CA3, and hilus   (MGI Ref ID J:77625)
  • reduced long term potentiation
    • mutants show faster LTP decay compared to wild-type   (MGI Ref ID J:77625)
  • seizures
    • after 60 minutes of perforant path stimulation, only brief seizure activity is seen in transgenic mice compared to wild-type controls; last seizure occurs 25 minutes after PPS   (MGI Ref ID J:77625)
    • decreased susceptibility to pharmacologically induced seizures
      • 30 mg/kg kainic acid treatment induces a few stage 5 seizures, resulting in death of 1/6 animals, but wild-type animals exhibit severe seizures, with death occurring in 5/6 animals within 30 minutes   (MGI Ref ID J:77625)
      • pentylene tetrazol (PTZ) treatment results in less severe seizures than those induced by kainic acid   (MGI Ref ID J:77625)
      • galanin agonist treatment reduces the latency and severity of PTZ-induced seizures   (MGI Ref ID J:77625)
  • homeostasis/metabolism phenotype
  • decreased sensitivity to xenobiotic induced morbidity/mortality
    • 1/6 mice die after 30 mg/kg kainic acid treatment compared to 5/6 wild-type mice   (MGI Ref ID J:77625)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Tg(DBH-Gal)1923Stei/0

        involves: C57BL/6 * SJL
  • behavior/neurological phenotype
  • increased thermal nociceptive threshold
    • paw withdrawal and tail flick latency are elevated compared to wild-type controls in response to radiant heat   (MGI Ref ID J:100969)
  • integument phenotype
  • increased thermal nociceptive threshold
    • paw withdrawal and tail flick latency are elevated compared to wild-type controls in response to radiant heat   (MGI Ref ID J:100969)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Neurobiology Research
Alzheimer's Disease
Epilepsy

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Tg(DBH-Gal)1923Stei
Allele Name transgene insertion 1923, Robert A Steiner
Allele Type Transgenic (Inserted expressed sequence)
Common Name(s) GALANIN-Tg; GALTG; GalOE; GalOE/D;
Mutation Made By Karen Hansen,   University of Washington
Strain of Origin(SJL x C57BL/6)F1
Expressed Gene Gal, galanin, mouse, laboratory
Promoter DBH, dopamine beta-hydroxylase (dopamine beta-monooxygenase), human
Molecular Note The transgene contains a 5.8 Kb sequence of human dopamine beta-hydroxylase promoter and a 4.6 Kb sequence of the mouse galanin gene. In situ hybridization analysis of brain detects a 5-fold increase in galanin mRNA levels in the locus coeruleus region. Radioimmunoassay reveals a 2-fold increase in gene product peptide level in the forebrain. An increase of galanin-like immunoreactive staining and fiber density is also detected. [MGI Ref ID J:77625]
 
 

Genotyping

Genotyping Information

Genotyping Protocols

Tg(DBH-Gal)1923Stei, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Mazarati AM; Hohmann JG; Bacon A; Liu H; Sankar R; Steiner RA; Wynick D; Wasterlain CG. 2000. Modulation of hippocampal excitability and seizures by galanin. J Neurosci 20(16):6276-81. [PubMed: 10934278]  [MGI Ref ID J:77625]

Additional References

Hohmann JG; Krasnow SM; Teklemichael DN; Clifton DK; Wynick D; Steiner RA. 2003. Neuroendocrine profiles in galanin-overexpressing and knockout mice. Neuroendocrinology 77(6):354-66. [PubMed: 12845222]  [MGI Ref ID J:84420]

Tg(DBH-Gal)1923Stei related

Blakeman KH; Holmberg K; Hao JX; Xu XJ; Kahl U; Lendahl U; Bartfai T; Wiesenfeld-Hallin Z; Hokfelt T. 2001. Mice over-expressing galanin have elevated heat nociceptive threshold. Neuroreport 12(2):423-5. [PubMed: 11209961]  [MGI Ref ID J:100969]

Hohmann JG; Krasnow SM; Teklemichael DN; Clifton DK; Wynick D; Steiner RA. 2003. Neuroendocrine profiles in galanin-overexpressing and knockout mice. Neuroendocrinology 77(6):354-66. [PubMed: 12845222]  [MGI Ref ID J:84420]

Holmes A; Li Q; Koenig EA; Gold E; Stephenson D; Yang RJ; Dreiling J; Sullivan T; Crawley JN. 2005. Phenotypic assessment of galanin overexpressing and galanin receptor R1 knockout mice in the tail suspension test for depression-related behavior. Psychopharmacology (Berl) 178(2-3):276-85. [PubMed: 15365683]  [MGI Ref ID J:110141]

Karatayev O; Baylan J; Leibowitz SF. 2009. Increased intake of ethanol and dietary fat in galanin overexpressing mice. Alcohol 43(8):571-80. [PubMed: 20004335]  [MGI Ref ID J:157471]

Kinney JW; Starosta G; Holmes A; Wrenn CC; Yang RJ; Harris AP; Long KC; Crawley JN. 2002. Deficits in trace cued fear conditioning in galanin-treated rats and galanin-overexpressing transgenic mice. Learn Mem 9(4):178-90. [PubMed: 12177231]  [MGI Ref ID J:130554]

Laplante F; Crawley JN; Quirion R. 2004. Selective reduction in ventral hippocampal acetylcholine release in awake galanin-treated rats and galanin-overexpressing transgenic mice. Regul Pept 122(2):91-8. [PubMed: 15380926]  [MGI Ref ID J:132463]

Steiner RA; Hohmann JG; Holmes A; Wrenn CC; Cadd G; Jureus A; Clifton DK; Luo M; Gutshall M; Ma SY; Mufson EJ; Crawley JN. 2001. Galanin transgenic mice display cognitive and neurochemical deficits characteristic of Alzheimer's disease. Proc Natl Acad Sci U S A 98(7):4184-9. [PubMed: 11259657]  [MGI Ref ID J:102197]

Wrenn CC; Marriott LK; Kinney JW; Holmes A; Wenk GL; Crawley JN. 2002. Galanin peptide levels in hippocampus and cortex of galanin-overexpressing transgenic mice evaluated for cognitive performance. Neuropeptides 36(6):413-26. [PubMed: 12507436]  [MGI Ref ID J:131253]

Wrenn CC; Turchi JN; Schlosser S; Dreiling JL; Stephenson DA; Crawley JN. 2006. Performance of galanin transgenic mice in the 5-choice serial reaction time attentional task. Pharmacol Biochem Behav 83(3):428-40. [PubMed: 16626795]  [MGI Ref ID J:128407]

Yoshitake T; Wang FH; Kuteeva E; Holmberg K; Yamaguchi M; Crawley JN; Steiner R; Bartfai T; Ogren SO; Hokfelt T; Kehr J. 2004. Enhanced hippocampal noradrenaline and serotonin release in galanin-overexpressing mice after repeated forced swimming test. Proc Natl Acad Sci U S A 101(1):354-9. [PubMed: 14701907]  [MGI Ref ID J:88271]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryThis transgenic strain originated on a B6;SJL background, was backcrossed for 7 generations on the C57BL/6J background.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2525.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3283.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   Noncarrier
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


(6.6)