Strain Name:

B6.129S4-Ccr2tm1Ifc/J

Stock Number:

004999

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Ccr2 deficient mice exhibit defective monocyte recruitment during immune responses.

Description

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
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Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Specieslaboratory mouse
GenerationN9+N2F12 (24-JAN-14)
Generation Definitions
 
Donating Investigator Israel F. Charo,   Gladstone Inst of Cardiovascular Disease, UCSF

Description
    Mice that are homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. No CCR2 mRNA is detected by RT-PCR analysis of spleen or thioglycollate elicited peritoneal exudate cells.
    The absence of the CCR2 chemokine receptor in these mice affects monocyte/macrophage infiltration leading to inflammatory responses, which, in turn, impact various systematic processes including immune response to various pathogens, reduced retinal vascularation, aggravation of mnesic deficits, pathogenesis of angiotensin II-induced cardiac fibrosis, exacerbation of collagen-induced arthritis, and reduced hepatic steatosis in obese mice.
    Specific effects include defective delayed-type hypersensitivity and production of Th1-type cytokine immune responses. Mycobacteria bovis purified protein derivative induced lung granulomas are initially smaller in size and contain fewer macrophages than wild-type controls. Ccr2-KO mice are extremely susceptible to pulmonary infection with Burkholderia mallei compared with wild-type mice. Increased mortality due to West Nile virus infection is seen. Mutant mice also exhibit decreased interferon-alpha production after lung granuloma induction. When challenged with thioglycollate treatment homozygotes respond with reduced peritoneal macrophage recruitment. Macrophages derived from these animals fail to migrate in response monocyte chemoattractant protein-1. Homozygotes are resistant to experimental autoimmune encephalomyelitis, a macrophage-mediated inflammatory disease.

Development
A targeting vector containing polII- neomycin resistance and herpes simplex virus thymidine kinase genes was used to disrupt the entire coding region except the first 39 nucleotides and 5' untranslated region. The construct was electroporated into 129S4/SvJae derived RF8 embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6 blastocysts. The resulting chimeric animals were crossed to C57BL/6 mice, and then backcrossed for nine generations to C57BL/6 mice (October 2003).

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of Ccr2
017586   B6.129(Cg)-Ccr2tm2.1Ifc/J
View Strains carrying other alleles of Ccr2     (1 strain)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Ccr2tm1Ifc/Ccr2tm1Ifc

        B6.129S4-Ccr2tm1Ifc/J
  • mortality/aging
  • increased susceptibility to viral infection induced morbidity/mortality
    • mouse hepatitis virus (MHV-V5A13.1)-infected mice exhibit increased mortality compared with similarly treated wild-type mice   (MGI Ref ID J:106738)
  • immune system phenotype
  • abnormal leukocyte physiology
    • in tumor models, myeloid suppressor cells exhibit 20- and 8-fold reduction migration into tumors and the spleen, respectively, compared with wild-type cells   (MGI Ref ID J:122119)
    • myeloid suppressor cells fail to promote growth of B16 melanoma cells when transplanted into wild-type mice unlike wild-type myeloid suppressor cells   (MGI Ref ID J:122119)
    • abnormal leukocyte migration
      • in mouse hepatitis virus (MHV-V5A13.1)-infected mice , T cells and microglia/macrophage infiltration of the central nervous system is decreased compared to in similarly treated wild-type mice   (MGI Ref ID J:106738)
    • abnormal microglial cell physiology
      • in mouse hepatitis virus (MHV-V5A13.1)-infected mice , microglia/macrophage infiltration of the central nervous system is decreased compared to in similarly treated wild-type mice   (MGI Ref ID J:106738)
    • abnormal osteoclast physiology
      • resorptive capacity of osteoclasts is decreased compared to wild-type cells   (MGI Ref ID J:149360)
  • abnormal osteoclast cell number
    • ovariectomized mice do not exhibit a change in osteoclast numbers unlike in similarly treated wild-type mice   (MGI Ref ID J:149360)
    • decreased osteoclast cell number
      • osteoclast number, covered bone surface, and size are decreased compared to in wild-type mice   (MGI Ref ID J:149360)
  • abnormal osteoclast differentiation
    • osteoclastogenesis from bone marrow macrophages is less extensive than from wild-type cells   (MGI Ref ID J:149360)
    • osteoclasts derived from bone marrow macrophages are smaller with fewer nuclei than cells derived from wild-type bone marrow macrophages   (MGI Ref ID J:149360)
    • differentiation of preosteoclasts in ovariectomized mice is impaired compared to in wild-type mice   (MGI Ref ID J:149360)
  • decreased acute inflammation
    • Th1 response to MHV-V5A13.1 infection is decreased compared to in wild-type mice   (MGI Ref ID J:106738)
  • decreased interferon-gamma secretion
    • 10-fold in the central nervous system of mouse hepatitis virus (MHV-V5A13.1)-infected mice   (MGI Ref ID J:106738)
  • increased susceptibility to viral infection
    • mouse hepatitis virus (MHV-V5A13.1)-infected mice exhibit increased mortality and viral recovery from the brain and decreased infiltration of T cells and microglia/macrophage in the central nervous system (CNS), IFN-gamma levels in the CNS, and demyelination compared with similarly treated wild-type mice   (MGI Ref ID J:106738)
    • increased susceptibility to viral infection induced morbidity/mortality
      • mouse hepatitis virus (MHV-V5A13.1)-infected mice exhibit increased mortality compared with similarly treated wild-type mice   (MGI Ref ID J:106738)
  • skeleton phenotype
  • abnormal bone mineral density
    • ovariectomized mice do not exhibit a change in bone marrow density unlike in similarly treated wild-type mice   (MGI Ref ID J:149360)
  • abnormal osteoclast cell number
    • ovariectomized mice do not exhibit a change in osteoclast numbers unlike in similarly treated wild-type mice   (MGI Ref ID J:149360)
    • decreased osteoclast cell number
      • osteoclast number, covered bone surface, and size are decreased compared to in wild-type mice   (MGI Ref ID J:149360)
  • abnormal osteoclast differentiation
    • osteoclastogenesis from bone marrow macrophages is less extensive than from wild-type cells   (MGI Ref ID J:149360)
    • osteoclasts derived from bone marrow macrophages are smaller with fewer nuclei than cells derived from wild-type bone marrow macrophages   (MGI Ref ID J:149360)
    • differentiation of preosteoclasts in ovariectomized mice is impaired compared to in wild-type mice   (MGI Ref ID J:149360)
  • abnormal osteoclast physiology
    • resorptive capacity of osteoclasts is decreased compared to wild-type cells   (MGI Ref ID J:149360)
  • abnormal trabecular bone morphology   (MGI Ref ID J:149360)
    • abnormal bone trabecula morphology
      • at 10 weeks, trabecular separation is decreased compared to in controls   (MGI Ref ID J:149360)
    • increased trabecular bone thickness   (MGI Ref ID J:149360)
    • increased trabecular bone volume
      • mice exhibit a greater increase in trabecular bone volume fraction between 6 weeks and 10 weeks compared to in wild-type mice   (MGI Ref ID J:149360)
  • decreased susceptibility to bone fracture
    • mice exhibit an increase in force-to-failure values compared with wild-type mice   (MGI Ref ID J:149360)
  • tumorigenesis
  • decreased tumor growth/size
    • myeloid suppressor cells fail to promote growth of B16 melanoma cells when transplanted into wild-type mice unlike wild-type myeloid suppressor cells   (MGI Ref ID J:122119)
  • nervous system phenotype
  • abnormal microglial cell physiology
    • in mouse hepatitis virus (MHV-V5A13.1)-infected mice , microglia/macrophage infiltration of the central nervous system is decreased compared to in similarly treated wild-type mice   (MGI Ref ID J:106738)
  • hematopoietic system phenotype
  • abnormal leukocyte physiology
    • in tumor models, myeloid suppressor cells exhibit 20- and 8-fold reduction migration into tumors and the spleen, respectively, compared with wild-type cells   (MGI Ref ID J:122119)
    • myeloid suppressor cells fail to promote growth of B16 melanoma cells when transplanted into wild-type mice unlike wild-type myeloid suppressor cells   (MGI Ref ID J:122119)
    • abnormal leukocyte migration
      • in mouse hepatitis virus (MHV-V5A13.1)-infected mice , T cells and microglia/macrophage infiltration of the central nervous system is decreased compared to in similarly treated wild-type mice   (MGI Ref ID J:106738)
    • abnormal microglial cell physiology
      • in mouse hepatitis virus (MHV-V5A13.1)-infected mice , microglia/macrophage infiltration of the central nervous system is decreased compared to in similarly treated wild-type mice   (MGI Ref ID J:106738)
    • abnormal osteoclast physiology
      • resorptive capacity of osteoclasts is decreased compared to wild-type cells   (MGI Ref ID J:149360)
  • abnormal osteoclast cell number
    • ovariectomized mice do not exhibit a change in osteoclast numbers unlike in similarly treated wild-type mice   (MGI Ref ID J:149360)
    • decreased osteoclast cell number
      • osteoclast number, covered bone surface, and size are decreased compared to in wild-type mice   (MGI Ref ID J:149360)
  • abnormal osteoclast differentiation
    • osteoclastogenesis from bone marrow macrophages is less extensive than from wild-type cells   (MGI Ref ID J:149360)
    • osteoclasts derived from bone marrow macrophages are smaller with fewer nuclei than cells derived from wild-type bone marrow macrophages   (MGI Ref ID J:149360)
    • differentiation of preosteoclasts in ovariectomized mice is impaired compared to in wild-type mice   (MGI Ref ID J:149360)
  • cellular phenotype
  • abnormal leukocyte migration
    • in mouse hepatitis virus (MHV-V5A13.1)-infected mice , T cells and microglia/macrophage infiltration of the central nervous system is decreased compared to in similarly treated wild-type mice   (MGI Ref ID J:106738)
  • abnormal osteoclast differentiation
    • osteoclastogenesis from bone marrow macrophages is less extensive than from wild-type cells   (MGI Ref ID J:149360)
    • osteoclasts derived from bone marrow macrophages are smaller with fewer nuclei than cells derived from wild-type bone marrow macrophages   (MGI Ref ID J:149360)
    • differentiation of preosteoclasts in ovariectomized mice is impaired compared to in wild-type mice   (MGI Ref ID J:149360)

Ccr2tm1Ifc/Ccr2tm1Ifc

        B6.129S4-Ccr2tm1Ifc
  • immune system phenotype
  • *normal* immune system phenotype
    • mice exhibit normal experimental autoimmune uveitis   (MGI Ref ID J:154558)
    • abnormal leukocyte tethering or rolling
      • monocyte rolling velocity is increased compared to in wild-type cells   (MGI Ref ID J:154558)
    • decreased susceptibility to induced colitis
      • DDS-treated mice fail to recruit macrophages and exhibit less colon shortening, weight loss, and clinical disease compared with similarly treated wild-type mice   (MGI Ref ID J:161138)
  • digestive/alimentary phenotype
  • decreased susceptibility to induced colitis
    • DDS-treated mice fail to recruit macrophages and exhibit less colon shortening, weight loss, and clinical disease compared with similarly treated wild-type mice   (MGI Ref ID J:161138)
  • cellular phenotype
  • abnormal leukocyte tethering or rolling
    • monocyte rolling velocity is increased compared to in wild-type cells   (MGI Ref ID J:154558)
  • hematopoietic system phenotype
  • abnormal leukocyte tethering or rolling
    • monocyte rolling velocity is increased compared to in wild-type cells   (MGI Ref ID J:154558)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Ccr2tm1Ifc/Ccr2+

        involves: 129S4/SvJae * C57BL/6
  • immune system phenotype
  • impaired macrophage chemotaxis
    • macrophages migrate in response to CCl2 is decreased unlike with similarly treated wild-type cells   (MGI Ref ID J:121703)
    • however, macrophage migration in response to CCL3, CCR1, and CCR5 is normal   (MGI Ref ID J:121703)
  • cellular phenotype
  • impaired macrophage chemotaxis
    • macrophages migrate in response to CCl2 is decreased unlike with similarly treated wild-type cells   (MGI Ref ID J:121703)
    • however, macrophage migration in response to CCL3, CCR1, and CCR5 is normal   (MGI Ref ID J:121703)
  • hematopoietic system phenotype
  • impaired macrophage chemotaxis
    • macrophages migrate in response to CCl2 is decreased unlike with similarly treated wild-type cells   (MGI Ref ID J:121703)
    • however, macrophage migration in response to CCL3, CCR1, and CCR5 is normal   (MGI Ref ID J:121703)

Ccr2tm1Ifc/Ccr2tm1Ifc

        involves: 129S4/SvJae
  • immune system phenotype
  • abnormal monocyte morphology
    • 7/4bri and 7/4dim cells in the blood are decreased even after mice are fed a high fat diet   (MGI Ref ID J:121281)
    • intraperitoneal thioglycollate challenge leads to an increase in 7/4bri cells   (MGI Ref ID J:121281)
  • hematopoietic system phenotype
  • abnormal monocyte morphology
    • 7/4bri and 7/4dim cells in the blood are decreased even after mice are fed a high fat diet   (MGI Ref ID J:121281)
    • intraperitoneal thioglycollate challenge leads to an increase in 7/4bri cells   (MGI Ref ID J:121281)

Ccr2tm1Ifc/Ccr2tm1Ifc

        involves: 129S4/SvJae * C57BL/6
  • immune system phenotype
  • abnormal Langerhans cell physiology
    • Langerhan cell repopulation after skin irradiation is impaired in these mice   (MGI Ref ID J:112594)
  • abnormal immune serum protein physiology   (MGI Ref ID J:118971)
    • decreased interferon-gamma secretion
      • in mice exposed to purified protein derivative (PPD) from Mycobacterium bovis   (MGI Ref ID J:44345)
      • in splenocytes treated with ConA   (MGI Ref ID J:44345)
      • in T cells and splenocytes from MOGp35-55 treated mice   (MGI Ref ID J:75838)
    • decreased interleukin-2 secretion
      • in mice exposed to purified protein derivative (PPD) from Mycobacterium bovis   (MGI Ref ID J:44345)
    • decreased interleukin-6 secretion
      • in splenocytes from MOGp35-55 treated mice   (MGI Ref ID J:75838)
    • increased interferon-gamma secretion
      • in the livers of mice subjected to acute challenge with acetaminophen (APAP)   (MGI Ref ID J:61542)
    • increased tumor necrosis factor secretion
      • in the livers of mice subjected to acute challenge with acetaminophen (APAP)   (MGI Ref ID J:61542)
  • abnormal macrophage chemotaxis
    • fewer thioglycollate-elicited macrophages are recovered compared to in similarly treated wild-type mice   (MGI Ref ID J:44345)
    • however, the number of resident macrophage in mice is normal   (MGI Ref ID J:44345)
    • impaired macrophage chemotaxis
      • in response to CCR2 agonists, macrophage migration is impaired compared with similarly treated wild-type cells   (MGI Ref ID J:44345)
      • however, migration in response to MIP-1alpha is normal   (MGI Ref ID J:44345)
      • following injection of [3H]FC cat LDL into muscles   (MGI Ref ID J:81363)
      • macrophages fail to migrate in response to CCl2 unlike similarly treated wild-type cells   (MGI Ref ID J:121703)
      • however, macrophage migration in response to CCL3, CCR1, and CCR5 is normal   (MGI Ref ID J:121703)
  • abnormal microglial cell physiology
    • microglia fail to accumulate at the site of beta-amyloid injection unlike in similarly treated wild-type mice   (MGI Ref ID J:121703)
  • decreased T cell proliferation
    • T cells from mice treated with MOGp35-55 exhibit 2 times less proliferation compared with T cells from similarly treated wild-type mice   (MGI Ref ID J:75838)
  • decreased inflammatory response
    • mice exposed to purified protein derivative (PPD) of Mycobacterium bovis produce smaller granulomas with fewer macrophages, no monocytosis, and decreased IFN-gamma and IL2 production compared with similarly treated wild-type mice   (MGI Ref ID J:44345)
    • decreased susceptibility to type I hypersensitivity reaction
      • mice sensitized and challenged with cockroach allergen exhibit attenuated airway hyperreactivity response, increased lung MCP-1 levels, and no histamine release compared with similarly treated wild-type mice   (MGI Ref ID J:118971)
      • mice treated MCP-1 exhibit decreased airway hyperreactivity response compared with similarly treated wild-type mice   (MGI Ref ID J:118971)
      • however, eosinophil accumulation is normal   (MGI Ref ID J:118971)
  • decreased splenocyte proliferation
    • splenocytes from mice treated with MOGp35-55 exhibit less proliferation than cells from similarly treated wild-type mice   (MGI Ref ID J:75838)
    • however, proliferation in response to ConA or anti-CD3 antibodies is normal   (MGI Ref ID J:75838)
  • decreased susceptibility to experimental autoimmune encephalomyelitis
    • MOGp35-55-treated mice fail to develop experimental autoimmune encephalomyelitis and exhibit no increase in chemokine production, reduced T cell and splenocyte proliferation, decreased IL6 production in splenocytes, and reduced IFN-gamma production in T cells and splenocytes compared with similarly treated wild-type mice   (MGI Ref ID J:75838)
    • however, monocyte recruitment in mice immunized with CFA beads is normal   (MGI Ref ID J:75838)
  • homeostasis/metabolism phenotype
  • abnormal lipid homeostasis
    • although serum levels of total and HDL cholesterol and phospholipids are slightly lower than in wild-type mice the difference was not statistically significant   (MGI Ref ID J:81363)
    • abnormal cholesterol homeostasis
      • cholesterol egress from muscles injected with [3H]FC cat LDL is slower than in similarly treated wild-type muscle due to a decrease in cholesteryl ester hydrolysis   (MGI Ref ID J:81363)
  • increased circulating alanine transaminase level
    • 120-fold above baseline in mice subjected to acute challenge with acetaminophen (APAP)   (MGI Ref ID J:61542)
  • increased physiological sensitivity to xenobiotic
    • mice subjected to acute challenge with acetaminophen (APAP) exhibit liver necrosis/apoptosis, liver hemorrhage, and increased hepatic MCP-1, IFN-gamma, and TNF-alpha levels compared with similarly treated wild-type mice   (MGI Ref ID J:61542)
    • however, IL13 hepatic production in response to APAP is normal and immunoneutralization of IFN-gamma or TNF-alpha attenuates hepatotoxicity induced by APAP   (MGI Ref ID J:61542)
  • liver/biliary system phenotype
  • hepatic necrosis
    • in mice subjected to acute challenge with acetaminophen (APAP)   (MGI Ref ID J:61542)
  • increased hepatocyte apoptosis
    • in mice subjected to acute challenge with acetaminophen (APAP)   (MGI Ref ID J:61542)
  • liver hemorrhage
    • in mice subjected to acute challenge with acetaminophen (APAP)   (MGI Ref ID J:61542)
  • cardiovascular system phenotype
  • liver hemorrhage
    • in mice subjected to acute challenge with acetaminophen (APAP)   (MGI Ref ID J:61542)
  • respiratory system phenotype
  • decreased airway responsiveness
    • mice sensitized and challenged with cockroach allergen exhibit attenuated airway hyperreactivity response compared with similarly treated wild-type mice   (MGI Ref ID J:118971)
    • mice treated MCP-1 exhibit decreased airway hyperreactivity response compared with similarly treated wild-type mice   (MGI Ref ID J:118971)
  • hematopoietic system phenotype
  • abnormal macrophage chemotaxis
    • fewer thioglycollate-elicited macrophages are recovered compared to in similarly treated wild-type mice   (MGI Ref ID J:44345)
    • however, the number of resident macrophage in mice is normal   (MGI Ref ID J:44345)
    • impaired macrophage chemotaxis
      • in response to CCR2 agonists, macrophage migration is impaired compared with similarly treated wild-type cells   (MGI Ref ID J:44345)
      • however, migration in response to MIP-1alpha is normal   (MGI Ref ID J:44345)
      • following injection of [3H]FC cat LDL into muscles   (MGI Ref ID J:81363)
      • macrophages fail to migrate in response to CCl2 unlike similarly treated wild-type cells   (MGI Ref ID J:121703)
      • however, macrophage migration in response to CCL3, CCR1, and CCR5 is normal   (MGI Ref ID J:121703)
  • abnormal microglial cell physiology
    • microglia fail to accumulate at the site of beta-amyloid injection unlike in similarly treated wild-type mice   (MGI Ref ID J:121703)
  • decreased T cell proliferation
    • T cells from mice treated with MOGp35-55 exhibit 2 times less proliferation compared with T cells from similarly treated wild-type mice   (MGI Ref ID J:75838)
  • decreased common myeloid progenitor cell number
    • colony-forming unit granulocyte macrophage fail to form in response to mJE and hMCP-1 stimulation of bone marrow cells unlike similarly treated wild-type cells   (MGI Ref ID J:44345)
    • however, the number of progenitor cells in the marrow, spleen, and peripheral blood is normal   (MGI Ref ID J:44345)
  • decreased splenocyte proliferation
    • splenocytes from mice treated with MOGp35-55 exhibit less proliferation than cells from similarly treated wild-type mice   (MGI Ref ID J:75838)
    • however, proliferation in response to ConA or anti-CD3 antibodies is normal   (MGI Ref ID J:75838)
  • nervous system phenotype
  • abnormal microglial cell physiology
    • microglia fail to accumulate at the site of beta-amyloid injection unlike in similarly treated wild-type mice   (MGI Ref ID J:121703)
  • cellular phenotype
  • abnormal macrophage chemotaxis
    • fewer thioglycollate-elicited macrophages are recovered compared to in similarly treated wild-type mice   (MGI Ref ID J:44345)
    • however, the number of resident macrophage in mice is normal   (MGI Ref ID J:44345)
    • impaired macrophage chemotaxis
      • in response to CCR2 agonists, macrophage migration is impaired compared with similarly treated wild-type cells   (MGI Ref ID J:44345)
      • however, migration in response to MIP-1alpha is normal   (MGI Ref ID J:44345)
      • following injection of [3H]FC cat LDL into muscles   (MGI Ref ID J:81363)
      • macrophages fail to migrate in response to CCl2 unlike similarly treated wild-type cells   (MGI Ref ID J:121703)
      • however, macrophage migration in response to CCL3, CCR1, and CCR5 is normal   (MGI Ref ID J:121703)
  • decreased splenocyte proliferation
    • splenocytes from mice treated with MOGp35-55 exhibit less proliferation than cells from similarly treated wild-type mice   (MGI Ref ID J:75838)
    • however, proliferation in response to ConA or anti-CD3 antibodies is normal   (MGI Ref ID J:75838)
  • increased hepatocyte apoptosis
    • in mice subjected to acute challenge with acetaminophen (APAP)   (MGI Ref ID J:61542)

Ccr2tm1Ifc/Ccr2tm1Ifc

        involves: 129S4/SvJae * C57BL/6J
  • cardiovascular system phenotype
  • abnormal vascular wound healing
    • cuff-induced neointimal hyperplasia is reduced compared to in similarly treated wild-type mice   (MGI Ref ID J:110790)
  • homeostasis/metabolism phenotype
  • abnormal vascular wound healing
    • cuff-induced neointimal hyperplasia is reduced compared to in similarly treated wild-type mice   (MGI Ref ID J:110790)
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Research Applications
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Ccr2tm1Ifc related

Immunology, Inflammation and Autoimmunity Research
Autoimmunity
      experimental allergic encephalomyelitis (EAE)

Research Tools
Immunology, Inflammation and Autoimmunity Research
      Macrophage Deficiency

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Ccr2tm1Ifc
Allele Name targeted mutation 1, Israel F Charo
Allele Type Targeted (Null/Knockout)
Common Name(s) CCR2-; Cmkbr2tm1Kuz;
Mutation Made By Israel Charo,   Gladstone Inst of Cardiovascular Disease, UCSF
Strain of Origin129S4/SvJae
ES Cell Line NameRF8
ES Cell Line Strain129S4/SvJae
Gene Symbol and Name Ccr2, chemokine (C-C motif) receptor 2
Chromosome 9
Gene Common Name(s) CC-CKR-2; CCR-2; CCR2A; CCR2B; CD192; CKR2; CKR2A; CKR2B; CMKBR2; Cmkbr2; MCP-1-R;
Molecular Note The coding region and 3' untranslated region are replaced with a polII-neo cassette. Absence of transcript was confirmed by RT-PCR using mRNA isolated from spleens and thioglycolate elicited peritoneal exudate cells of homozygous mutant animals. [MGI Ref ID J:44345]

Genotyping

Genotyping Information

Genotyping Protocols

Ccr2tm1Ifc, Melt Curve Analysis
Ccr2tm1Ifc, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Boring L; Gosling J; Chensue SW; Kunkel SL; Farese RV Jr; Broxmeyer HE; Charo IF. 1997. Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice. J Clin Invest 100(10):2552-61. [PubMed: 9366570]  [MGI Ref ID J:44345]

Additional References

Izikson L; Klein RS; Charo IF; Weiner HL; Luster AD. 2000. Resistance to experimental autoimmune encephalomyelitis in mice lacking the CC chemokine receptor (CCR)2. J Exp Med 192(7):1075-80. [PubMed: 11015448]  [MGI Ref ID J:75838]

Ccr2tm1Ifc related

Aldridge JR Jr; Moseley CE; Boltz DA; Negovetich NJ; Reynolds C; Franks J; Brown SA; Doherty PC; Webster RG; Thomas PG. 2009. TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection. Proc Natl Acad Sci U S A 106(13):5306-11. [PubMed: 19279209]  [MGI Ref ID J:147144]

Antonelli LR; Gigliotti Rothfuchs A; Goncalves R; Roffe E; Cheever AW; Bafica A; Salazar AM; Feng CG; Sher A. 2010. Intranasal Poly-IC treatment exacerbates tuberculosis in mice through the pulmonary recruitment of a pathogen-permissive monocyte/macrophage population. J Clin Invest 120(5):1674-82. [PubMed: 20389020]  [MGI Ref ID J:161475]

Avraham-Davidi I; Yona S; Grunewald M; Landsman L; Cochain C; Silvestre JS; Mizrahi H; Faroja M; Strauss-Ayali D; Mack M; Jung S; Keshet E. 2013. On-site education of VEGF-recruited monocytes improves their performance as angiogenic and arteriogenic accessory cells. J Exp Med 210(12):2611-25. [PubMed: 24166715]  [MGI Ref ID J:207718]

Bamboat ZM; Ocuin LM; Balachandran VP; Obaid H; Plitas G; Dematteo RP. 2010. Conventional DCs reduce liver ischemia/reperfusion injury in mice via IL-10 secretion. J Clin Invest 120(2):559-69. [PubMed: 20093775]  [MGI Ref ID J:156672]

Belarbi K; Jopson T; Arellano C; Fike JR; Rosi S. 2013. CCR2 deficiency prevents neuronal dysfunction and cognitive impairments induced by cranial irradiation. Cancer Res 73(3):1201-10. [PubMed: 23243025]  [MGI Ref ID J:194366]

Bierly AL; Shufesky WJ; Sukhumavasi W; Morelli AE; Denkers EY. 2008. Dendritic cells expressing plasmacytoid marker PDCA-1 are Trojan horses during Toxoplasma gondii infection. J Immunol 181(12):8485-91. [PubMed: 19050266]  [MGI Ref ID J:142065]

Binder NB; Niederreiter B; Hoffmann O; Stange R; Pap T; Stulnig TM; Mack M; Erben RG; Smolen JS; Redlich K. 2009. Estrogen-dependent and C-C chemokine receptor-2-dependent pathways determine osteoclast behavior in osteoporosis. Nat Med 15(4):417-24. [PubMed: 19330010]  [MGI Ref ID J:149360]

Blease K; Mehrad B; Standiford TJ; Lukacs NW; Gosling J; Boring L; Charo IF; Kunkel SL; Hogaboam CM. 2000. Enhanced pulmonary allergic responses to Aspergillus in CCR2-/- mice. J Immunol 165(5):2603-11. [PubMed: 10946288]  [MGI Ref ID J:64054]

Boring L; Gosling J; Cleary M; Charo IF. 1998. Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis. Nature 394(6696):894-7. [PubMed: 9732872]  [MGI Ref ID J:111471]

Bromley SK; Larson RP; Ziegler SF; Luster AD. 2013. IL-23 induces atopic dermatitis-like inflammation instead of psoriasis-like inflammation in CCR2-deficient mice. PLoS One 8(3):e58196. [PubMed: 23472158]  [MGI Ref ID J:199389]

Campbell EM; Charo IF; Kunkel SL; Strieter RM; Boring L; Gosling J; Lukacs NW. 1999. Monocyte chemoattractant protein-1 mediates cockroach allergen-induced bronchial hyperreactivity in normal but not CCR2-/- mice: the role of mast cells. J Immunol 163(4):2160-7. [PubMed: 10438957]  [MGI Ref ID J:118971]

Capoccia BJ; Gregory AD; Link DC. 2008. Recruitment of the inflammatory subset of monocytes to sites of ischemia induces angiogenesis in a monocyte chemoattractant protein-1-dependent fashion. J Leukoc Biol 84(3):760-8. [PubMed: 18550788]  [MGI Ref ID J:138153]

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Panoskaltsis-Mortari A; Hermanson JR; Taras E; Wangensteen OD; Charo IF; Rollins BJ; Blazar BR. 2004. Post-BMT lung injury occurs independently of the expression of CCL2 or its receptor, CCR2, on host cells. Am J Physiol Lung Cell Mol Physiol 286(2):L284-92. [PubMed: 14527928]  [MGI Ref ID J:101226]

Peters W; Cyster JG; Mack M; Schlondorff D; Wolf AJ; Ernst JD; Charo IF. 2004. CCR2-dependent trafficking of F4/80dim macrophages and CD11cdim/intermediate dendritic cells is crucial for T cell recruitment to lungs infected with Mycobacterium tuberculosis. J Immunol 172(12):7647-53. [PubMed: 15187146]  [MGI Ref ID J:90822]

Peters W; Dupuis M; Charo IF. 2000. A mechanism for the impaired IFN-gamma production in C-C chemokine receptor 2 (CCR2) knockout mice: role of CCR2 in linking the innate and adaptive immune responses J Immunol 165(12):7072-7. [PubMed: 11120836]  [MGI Ref ID J:66108]

Plantinga M; Guilliams M; Vanheerswynghels M; Deswarte K; Branco-Madeira F; Toussaint W; Vanhoutte L; Neyt K; Killeen N; Malissen B; Hammad H; Lambrecht BN. 2013. Conventional and Monocyte-Derived CD11b(+) Dendritic Cells Initiate and Maintain T Helper 2 Cell-Mediated Immunity to House Dust Mite Allergen. Immunity 38(2):322-35. [PubMed: 23352232]  [MGI Ref ID J:193483]

Platt AM; Bain CC; Bordon Y; Sester DP; Mowat AM. 2010. An independent subset of TLR expressing CCR2-dependent macrophages promotes colonic inflammation. J Immunol 184(12):6843-54. [PubMed: 20483766]  [MGI Ref ID J:161138]

Qian BZ; Li J; Zhang H; Kitamura T; Zhang J; Campion LR; Kaiser EA; Snyder LA; Pollard JW. 2011. CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis. Nature 475(7355):222-5. [PubMed: 21654748]  [MGI Ref ID J:186831]

Qu C; Edwards EW; Tacke F; Angeli V; Llodra J; Sanchez-Schmitz G; Garin A; Haque NS; Peters W; van Rooijen N; Sanchez-Torres C; Bromberg J; Charo IF; Jung S; Lira SA; Randolph GJ. 2004. Role of CCR8 and other chemokine pathways in the migration of monocyte-derived dendritic cells to lymph nodes. J Exp Med 200(10):1231-41. [PubMed: 15534368]  [MGI Ref ID J:94536]

Raber J; Allen AR; Rosi S; Sharma S; Dayger C; Davis MJ; Fike JR. 2013. Effects of (56)Fe radiation on hippocampal function in mice deficient in chemokine receptor 2 (CCR2). Behav Brain Res 246:69-75. [PubMed: 23500678]  [MGI Ref ID J:197529]

Rafei M; Hsieh J; Fortier S; Li M; Yuan S; Birman E; Forner K; Boivin MN; Doody K; Tremblay M; Annabi B; Galipeau J. 2008. Mesenchymal stromal cell-derived CCL2 suppresses plasma cell immunoglobulin production via STAT3 inactivation and PAX5 induction. Blood 112(13):4991-8. [PubMed: 18812467]  [MGI Ref ID J:144261]

Rampersad RR; Tarrant TK; Vallanat CT; Quintero-Matthews T; Weeks MF; Esserman DA; Clark J; Di Padova F; Patel DD; Fong AM; Liu P. 2011. Enhanced Th17-cell responses render CCR2-deficient mice more susceptible for autoimmune arthritis. PLoS One 6(10):e25833. [PubMed: 21991368]  [MGI Ref ID J:178121]

Rangel-Moreno J; Carragher DM; de la Luz Garcia-Hernandez M; Hwang JY; Kusser K; Hartson L; Kolls JK; Khader SA; Randall TD. 2011. The development of inducible bronchus-associated lymphoid tissue depends on IL-17. Nat Immunol 12(7):639-46. [PubMed: 21666689]  [MGI Ref ID J:174312]

Ren G; Zhao X; Wang Y; Zhang X; Chen X; Xu C; Yuan ZR; Roberts AI; Zhang L; Zheng B; Wen T; Han Y; Rabson AB; Tischfield JA; Shao C; Shi Y. 2012. CCR2-dependent recruitment of macrophages by tumor-educated mesenchymal stromal cells promotes tumor development and is mimicked by TNFalpha. Cell Stem Cell 11(6):812-24. [PubMed: 23168163]  [MGI Ref ID J:194684]

Roy RM; Wuthrich M; Klein BS. 2012. Chitin elicits CCL2 from airway epithelial cells and induces CCR2-dependent innate allergic inflammation in the lung. J Immunol 189(5):2545-52. [PubMed: 22851704]  [MGI Ref ID J:189859]

Ruckh JM; Zhao JW; Shadrach JL; van Wijngaarden P; Rao TN; Wagers AJ; Franklin RJ. 2012. Rejuvenation of regeneration in the aging central nervous system. Cell Stem Cell 10(1):96-103. [PubMed: 22226359]  [MGI Ref ID J:181499]

Saederup N; Chan L; Lira SA; Charo IF. 2008. Fractalkine deficiency markedly reduces macrophage accumulation and atherosclerotic lesion formation in CCR2-/- mice: evidence for independent chemokine functions in atherogenesis. Circulation 117(13):1642-8. [PubMed: 18165355]  [MGI Ref ID J:153310]

Said N; Sanchez-Carbayo M; Smith SC; Theodorescu D. 2012. RhoGDI2 suppresses lung metastasis in mice by reducing tumor versican expression and macrophage infiltration. J Clin Invest 122(4):1503-18. [PubMed: 22406535]  [MGI Ref ID J:184557]

Satpathy AT; Briseno CG; Lee JS; Ng D; Manieri NA; Kc W; Wu X; Thomas SR; Lee WL; Turkoz M; McDonald KG; Meredith MM; Song C; Guidos CJ; Newberry RD; Ouyang W; Murphy TL; Stappenbeck TS; Gommerman JL; Nussenzweig MC; Colonna M; Kopan R; Murphy KM. 2013. Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens. Nat Immunol 14(9):937-48. [PubMed: 23913046]  [MGI Ref ID J:208234]

Sawanobori Y; Ueha S; Kurachi M; Shimaoka T; Talmadge JE; Abe J; Shono Y; Kitabatake M; Kakimi K; Mukaida N; Matsushima K. 2008. Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice. Blood 111(12):5457-66. [PubMed: 18375791]  [MGI Ref ID J:136844]

Scholten D; Reichart D; Paik YH; Lindert J; Bhattacharya J; Glass CK; Brenner DA; Kisseleva T. 2011. Migration of fibrocytes in fibrogenic liver injury. Am J Pathol 179(1):189-98. [PubMed: 21703401]  [MGI Ref ID J:173686]

Scott HM; Flynn JL. 2002. Mycobacterium tuberculosis in Chemokine Receptor 2-Deficient Mice: Influence of Dose on Disease Progression. Infect Immun 70(11):5946-54. [PubMed: 12379669]  [MGI Ref ID J:79751]

Sere K; Baek JH; Ober-Blobaum J; Muller-Newen G; Tacke F; Yokota Y; Zenke M; Hieronymus T. 2012. Two distinct types of Langerhans cells populate the skin during steady state and inflammation. Immunity 37(5):905-16. [PubMed: 23159228]  [MGI Ref ID J:190439]

Si Y; Tsou CL; Croft K; Charo IF. 2010. CCR2 mediates hematopoietic stem and progenitor cell trafficking to sites of inflammation in mice. J Clin Invest 120(4):1192-203. [PubMed: 20234092]  [MGI Ref ID J:159685]

Soudja SM; Ruiz AL; Marie JC; Lauvau G. 2012. Inflammatory Monocytes Activate Memory CD8(+) T and Innate NK Lymphocytes Independent of Cognate Antigen during Microbial Pathogen Invasion. Immunity 37(3):549-62. [PubMed: 22940097]  [MGI Ref ID J:187687]

Spear P; Barber A; Rynda-Apple A; Sentman CL. 2012. Chimeric antigen receptor T cells shape myeloid cell function within the tumor microenvironment through IFN-gamma and GM-CSF. J Immunol 188(12):6389-98. [PubMed: 22586039]  [MGI Ref ID J:188969]

Stein O; Dabach Y; Ben-Naim M; Halperin G; Charo IF; Stein Y. 2003. In CCR2-/- mice monocyte recruitment and egress of LDL cholesterol in vivo is impaired. Biochem Biophys Res Commun 300(2):477-81. [PubMed: 12504109]  [MGI Ref ID J:81363]

Sullivan T; Miao Z; Dairaghi DJ; Krasinski A; Wang Y; Zhao BN; Baumgart T; Ertl LS; Pennell A; Seitz L; Powers J; Zhao R; Ungashe S; Wei Z; Boring L; Tsou CL; Charo I; Berahovich RD; Schall TJ; Jaen JC. 2013. CCR2 antagonist CCX140-B provides renal and glycemic benefits in diabetic transgenic human CCR2 knockin mice. Am J Physiol Renal Physiol 305(9):F1288-97. [PubMed: 23986513]  [MGI Ref ID J:203000]

Sumida H; Yanagida K; Kita Y; Abe J; Matsushima K; Nakamura M; Ishii S; Sato S; Shimizu T. 2014. Interplay between CXCR2 and BLT1 facilitates neutrophil infiltration and resultant keratinocyte activation in a murine model of imiquimod-induced psoriasis. J Immunol 192(9):4361-9. [PubMed: 24663678]  [MGI Ref ID J:209983]

Suresh MV; Yu B; Machado-Aranda D; Bender MD; Ochoa-Frongia L; Helinski JD; Davidson BA; Knight PR; Hogaboam CM; Moore BB; Raghavendran K. 2012. Role of macrophage chemoattractant protein-1 in acute inflammation after lung contusion. Am J Respir Cell Mol Biol 46(6):797-806. [PubMed: 22281985]  [MGI Ref ID J:197889]

Suzuki M; Tsujikawa M; Itabe H; Du ZJ; Xie P; Matsumura N; Fu X; Zhang R; Sonoda KH; Egashira K; Hazen SL; Kamei M. 2012. Chronic photo-oxidative stress and subsequent MCP-1 activation as causative factors for age-related macular degeneration. J Cell Sci 125(Pt 10):2407-15. [PubMed: 22357958]  [MGI Ref ID J:197709]

Swirski FK; Libby P; Aikawa E; Alcaide P; Luscinskas FW; Weissleder R; Pittet MJ. 2007. Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata. J Clin Invest 117(1):195-205. [PubMed: 17200719]  [MGI Ref ID J:117447]

Szymczak WA; Deepe GS Jr. 2010. Antigen-presenting dendritic cells rescue CD4-depleted CCR2-/- mice from lethal Histoplasma capsulatum infection. Infect Immun 78(5):2125-37. [PubMed: 20194586]  [MGI Ref ID J:159184]

Szymczak WA; Deepe GS Jr. 2009. The CCL7-CCL2-CCR2 axis regulates IL-4 production in lungs and fungal immunity. J Immunol 183(3):1964-74. [PubMed: 19587014]  [MGI Ref ID J:151704]

Tamoutounour S; Guilliams M; Montanana Sanchis F; Liu H; Terhorst D; Malosse C; Pollet E; Ardouin L; Luche H; Sanchez C; Dalod M; Malissen B; Henri S. 2013. Origins and functional specialization of macrophages and of conventional and monocyte-derived dendritic cells in mouse skin. Immunity 39(5):925-38. [PubMed: 24184057]  [MGI Ref ID J:209012]

Tamoutounour S; Henri S; Lelouard H; de Bovis B; de Haar C; van der Woude CJ; Woltman AM; Reyal Y; Bonnet D; Sichien D; Bain CC; Mowat AM; Reis E Sousa C; Poulin LF; Malissen B; Guilliams M. 2012. CD64 distinguishes macrophages from dendritic cells in the gut and reveals the Th1-inducing role of mesenteric lymph node macrophages during colitis. Eur J Immunol 42(12):3150-66. [PubMed: 22936024]  [MGI Ref ID J:190343]

Tieu BC; Lee C; Sun H; Lejeune W; Recinos A rd; Ju X; Spratt H; Guo DC; Milewicz D; Tilton RG; Brasier AR. 2009. An adventitial IL-6/MCP1 amplification loop accelerates macrophage-mediated vascular inflammation leading to aortic dissection in mice. J Clin Invest 119(12):3637-51. [PubMed: 19920349]  [MGI Ref ID J:155563]

Tsou CL; Peters W; Si Y; Slaymaker S; Aslanian AM; Weisberg SP; Mack M; Charo IF. 2007. Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites. J Clin Invest 117(4):902-9. [PubMed: 17364026]  [MGI Ref ID J:121281]

Tsuji Y; Watanabe T; Kudo M; Arai H; Strober W; Chiba T. 2012. Sensing of Commensal Organisms by the Intracellular Sensor NOD1 Mediates Experimental Pancreatitis. Immunity 37(2):326-38. [PubMed: 22902233]  [MGI Ref ID J:187368]

Tsutsumi C; Sonoda KH; Egashira K; Qiao H; Hisatomi T; Nakao S; Ishibashi M; Charo IF; Sakamoto T; Murata T; Ishibashi T. 2003. The critical role of ocular-infiltrating macrophages in the development of choroidal neovascularization. J Leukoc Biol 74(1):25-32. [PubMed: 12832439]  [MGI Ref ID J:84364]

Veillard NR; Steffens S; Pelli G; Lu B; Kwak BR; Gerard C; Charo IF; Mach F. 2005. Differential influence of chemokine receptors CCR2 and CXCR3 in development of atherosclerosis in vivo. Circulation 112(6):870-8. [PubMed: 16061736]  [MGI Ref ID J:116866]

Wareing MD; Lyon A; Inglis C; Giannoni F; Charo I; Sarawar SR. 2007. Chemokine regulation of the inflammatory response to a low-dose influenza infection in CCR2-/- mice. J Leukoc Biol 81(3):793-801. [PubMed: 17179466]  [MGI Ref ID J:118612]

Warmington KS; Boring L; Ruth JH; Sonstein J; Hogaboam CM; Curtis JL; Kunkel SL; Charo IR; Chensue SW. 1999. Effect of C-C chemokine receptor 2 (CCR2) knockout on type-2 (schistosomal antigen-elicited) pulmonary granuloma formation: analysis of cellular recruitment and cytokine responses. Am J Pathol 154(5):1407-16. [PubMed: 10329593]  [MGI Ref ID J:108261]

Weidanz WP; Lafleur G; Brown A; Burns JM Jr; Gramaglia I; van der Heyde HC. 2010. {gamma}{delta} T Cells but Not NK Cells Are Essential for Cell-Mediated Immunity against Plasmodium chabaudi Malaria. Infect Immun 78(10):4331-40. [PubMed: 20660608]  [MGI Ref ID J:164250]

Weisberg SP; Hunter D; Huber R; Lemieux J; Slaymaker S; Vaddi K; Charo I; Leibel RL; Ferrante AW Jr. 2006. CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest 116(1):115-24. [PubMed: 16341265]  [MGI Ref ID J:105358]

Weizman N; Krelin Y; Shabtay-Orbach A; Amit M; Binenbaum Y; Wong RJ; Gil Z. 2014. Macrophages mediate gemcitabine resistance of pancreatic adenocarcinoma by upregulating cytidine deaminase. Oncogene 33(29):3812-9. [PubMed: 23995783]  [MGI Ref ID J:212746]

Westcott DJ; Delproposto JB; Geletka LM; Wang T; Singer K; Saltiel AR; Lumeng CN. 2009. MGL1 promotes adipose tissue inflammation and insulin resistance by regulating 7/4hi monocytes in obesity. J Exp Med 206(13):3143-56. [PubMed: 19995956]  [MGI Ref ID J:155676]

Wolf MJ; Hoos A; Bauer J; Boettcher S; Knust M; Weber A; Simonavicius N; Schneider C; Lang M; Sturzl M; Croner RS; Konrad A; Manz MG; Moch H; Aguzzi A; van Loo G; Pasparakis M; Prinz M; Borsig L; Heikenwalder M. 2012. Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway. Cancer Cell 22(1):91-105. [PubMed: 22789541]  [MGI Ref ID J:191014]

Wuthrich M; Ersland K; Sullivan T; Galles K; Klein BS. 2012. Fungi Subvert Vaccine T Cell Priming at the Respiratory Mucosa by Preventing Chemokine-Induced Influx of Inflammatory Monocytes. Immunity :. [PubMed: 22483803]  [MGI Ref ID J:182207]

Xing Z; Lu C; Hu D; Yu YY; Wang X; Colnot C; Nakamura M; Wu Y; Miclau T; Marcucio RS. 2010. Multiple roles for CCR2 during fracture healing. Dis Model Mech 3(7-8):451-8. [PubMed: 20354109]  [MGI Ref ID J:161547]

Xu J; Lin SC; Chen J; Miao Y; Taffet GE; Entman ML; Wang Y. 2011. CCR2 mediates the uptake of bone marrow-derived fibroblast precursors in angiotensin II-induced cardiac fibrosis. Am J Physiol Heart Circ Physiol 301(2):H538-47. [PubMed: 21572015]  [MGI Ref ID J:174889]

Yamagami S; Hamrah P; Miyamoto K; Miyazaki D; Dekaris I; Dawson T; Lu B; Gerard C; Dana MR. 2005. CCR5 chemokine receptor mediates recruitment of MHC class II-positive Langerhans cells in the mouse corneal epithelium. Invest Ophthalmol Vis Sci 46(4):1201-7. [PubMed: 15790880]  [MGI Ref ID J:104985]

Yao Y; Tsirka SE. 2012. The CCL2-CCR2 system affects the progression and clearance of intracerebral hemorrhage. Glia 60(6):908-18. [PubMed: 22419223]  [MGI Ref ID J:183881]

Yona S; Kim KW; Wolf Y; Mildner A; Varol D; Breker M; Strauss-Ayali D; Viukov S; Guilliams M; Misharin A; Hume DA; Perlman H; Malissen B; Zelzer E; Jung S. 2013. Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis. Immunity 38(1):79-91. [PubMed: 23273845]  [MGI Ref ID J:193038]

Yuan Q; Bromley SK; Means TK; Jones KJ; Hayashi F; Bhan AK; Luster AD. 2007. CCR4-dependent regulatory T cell function in inflammatory bowel disease. J Exp Med 204(6):1327-34. [PubMed: 17548518]  [MGI Ref ID J:125857]

Zaidi MR; Davis S; Noonan FP; Graff-Cherry C; Hawley TS; Walker RL; Feigenbaum L; Fuchs E; Lyakh L; Young HA; Hornyak TJ; Arnheiter H; Trinchieri G; Meltzer PS; De Fabo EC; Merlino G. 2011. Interferon-gamma links ultraviolet radiation to melanomagenesis in mice. Nature 469(7331):548-53. [PubMed: 21248750]  [MGI Ref ID J:172414]

Zhang N; Schroppel B; Lal G; Jakubzick C; Mao X; Chen D; Yin N; Jessberger R; Ochando JC; Ding Y; Bromberg JS. 2009. Regulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune response. Immunity 30(3):458-69. [PubMed: 19303390]  [MGI Ref ID J:147032]

Zhu Z; Ma B; Zheng T; Homer RJ; Lee CG; Charo IF; Noble P; Elias JA. 2002. IL-13-induced chemokine responses in the lung: role of CCR2 in the pathogenesis of IL-13-induced inflammation and remodeling. J Immunol 168(6):2953-62. [PubMed: 11884467]  [MGI Ref ID J:126677]

van Helden MJ; Zaiss DM; Sijts AJ. 2012. CCR2 defines a distinct population of NK cells and mediates their migration during influenza virus infection in mice. PLoS One 7(12):e52027. [PubMed: 23272202]  [MGI Ref ID J:195645]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX12

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, homozygous mice may be bred together.
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $182.00Female or MaleHomozygous for Ccr2tm1Ifc  
Price per Pair (US dollars $)Pair Genotype
$364.00Homozygous for Ccr2tm1Ifc x Homozygous for Ccr2tm1Ifc  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $236.60Female or MaleHomozygous for Ccr2tm1Ifc  
Price per Pair (US dollars $)Pair Genotype
$473.20Homozygous for Ccr2tm1Ifc x Homozygous for Ccr2tm1Ifc  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

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In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

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In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

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The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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