JAX Mice Database - 005012 A.B6 Tyr<+>-Myo5a<d-l31J>/J

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Strain Name:	A.B6 Tyr⁺-Myo5a^d-l31J/J
Stock Number:	005012
Availability:	Repository-Cryopreserved

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General Terms and Conditions

Former Name	A.B6 Tyr⁺-nmf244/J (Changed: 28-MAR-06 )
	NMF244 (Changed: 10-AUG-05 )
Genes & Alleles	Myo5a; Myo5a^d-l31J; Tyr; Tyr⁺;

Product Information

Strain Details

Type JAX^® GEMM^® Strain - Chemically Induced Mutation

Additional information on JAX^® GEMM^® Strains.

Type JAX^® GEMM^® Strain - Congenic

Type JAX^® GEMM^® Strain - Mutant Strain

Species laboratory mouse

H2 Haplotype a

Generation N4F1+N1p (26-FEB-06)

Strain Description
View strain phenotype and additional information on the Neuroscience Mutagenesis Facility web page.

Mammalian Phenotype Terms assigned by genotype

Myo5a^d-l31J/Myo5a^d-l31J
involves: A.B6-Tyr⁺
life span-post-weaning/aging

premature death (J:87349)

mice are fragile and usually die by or before 5 weeks of age

behavior/neurological phenotype

abnormal voluntary movement (J:87349)

impaired hind limb movements

they show 'hot-foot' like behavior of one or both limbs

impaired balance (J:87349)

mice intermittently lean to the side, fall over, but are able to regain their walking position

growth/size phenotype

decreased body size (J:87349)

animals are small

pigmentation phenotype

abnormal coat color (J:87349)

mice exhibit a non-agouti grey coat color that appears to result from a non-agouti grey allele that is known to exist in heterozygotes for the dilute-lethal allele of Myo5a, and becomes apparent in the presence of the agouti dilute allele, carried by the female NMF244

skin/coat/nails phenotype

abnormal coat color (J:87349)

mice exhibit a non-agouti grey coat color that appears to result from a non-agouti grey allele that is known to exist in heterozygotes for the dilute-lethal allele of Myo5a, and becomes apparent in the presence of the agouti dilute allele, carried by the female NMF244

Gene & Allele Details

Allele Symbol		Myo5a^d-l31J
Allele Name		dilute lethal 31 Jackson
Common Name(s)		Myo5a^nmf244; NMF244; neuroscience mutagenesis facility, 244;
Strain of Origin		A.B6-Tyr⁺
Gene Symbol and Name		Myo5a, myosin Va
Chromosome		9
Gene Common Name(s)		9630007J19Rik; AI413174; AI661011; D; Dbv; Dop; GS1; MVa; MYH12; MYO5; MYR12; Myo5; MyoVA; RIKEN cDNA 9630007J19 gene; d; dilute; expressed sequence AI413174; expressed sequence AI661011; flail; flailer; flr; myosin V; nmf244;
Molecular Note		This phenotypic mutant was identified in an ENU mutagenesis screen. Complementation tests between heterozygous NMF244 and DLS/LeJ mice produced six affected mice in a total of 22 progeny, suggesting that NMF244 represents a new allele of dilute-lethal inthis gene.

Allele Symbol		Tyr⁺
Allele Name		wild type
Gene Symbol and Name		Tyr, tyrosinase
Chromosome		7
Gene Common Name(s)		C; OCA1A; OCAIA; SHEP3; albino; c; skc35; skin/coat color 35;

Related Strains

Strains carrying Tyr⁺ allele

000090 129S1/Sv-Oca2⁺ Tyr⁺ Kitl^Sl-J/J

005445 A.B6 Tyr⁺-Cyba^nmf333/J

002565 A.B6-Tyr⁺/J

000822 B6 x 129S1/SvEi Oca2⁺ Tyr⁺-Vsx2^or-J/J

000899 C.B6-Tyr⁺ Hbb^s/J

000494 J.Cg-Oca2⁺ Tyr⁺ Lyst^bg/J

002281 NFS.C58-Tyr⁺/J

004304 NOD.CBALs-Tyr⁺/LtJ

View Strains carrying Tyr⁺ (8 strains)

Strains carrying other alleles of Myo5a

001013 B10.D2/nSnJ-Myo5a^d-n/J

000502 B6 x B6CBCa A^w-J/A-Myo5a^flr Gnb5^flr/J

000285 B6.Cg-Rora^sg + +/+ Myo5a^d Bmp5^se/J

000284 CWD/LeJ

000963 DBA/2J-Myo5a^d+17J/Myo5a^d/J

000964 DBA/2J-Myo5a^d+18J/Myo5a^d/J

000067 DBA/2J-Myo5a^d+2J/Myo5a^d/J

000253 DLS/LeJ

001850 MEV-Q/TyJ

001855 MEV-V/TyJ

003345 MEV/2Ty-Emv64/J

000390 STOCK Myo5a^d Ds/J

000994 STOCK a Myo5a^d Mreg^dsu/J

000286 STOCK a/a Myo5a^d fd/+ +/J

View Strains carrying other alleles of Myo5a (14 strains)

Strains carrying other alleles of Tyr

000091 129T1/Sv-Oca2⁺ Tyr^c-ch Dnd1^Ter/J

001279 129T1/Sv-Oca2⁺ Tyr^c-ch-Aft/J

000409 B10.129P-H1^b Hbb^d Tyr^c Ea7^a/(5M)oSnJ

000418 B10.129P-H1^b Tyr^c Hbb^d/(5M)nSnJ

000432 B10.C-H1^b Hbb^d Tyr^c/(41N)SnJ

000580 B10.D2/nSn-Tyr^c-4J/J

000578 B6 x STOCK Tyr^c-ch Bmp5^se +/+ Myo6^sv/J

000058 B6(Cg)-Tyr^c-2J/J

000383 B6.C-Tyr^c H1^b Hbb^d/ByJ

007484 B6.Cg-Tyr^c-2J Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ

000035 B6.Cg-Tyr^c-J/J

000104 B6.Cg-Tyr^c-h/J

000054 B6.D2-Tyr^c-p/J

000339 C3H/HeJ-Tyr^c-9J/J

001294 C3H/HeJ-Tyr^c-a/J

001002 C57BL/10SnJ-Tyr^c-11J/J

001006 CBA/J-Tyr^c-10J/J

000657 CE/J

000619 FS/EiJ

004828 FVB.129P2-Pde6b⁺ Tyr^c-ch/AntJ

007483 FVB.Cg-Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ

005115 NOD.FVB-Tg(INS-MT2A,Tyr)1Pne/PneJ

005114 NOD.FVB-Tg(Ins1-Cat,Tyr)25Pne/PneJ

000271 SH1/LeJ

001759 STOCK A Tyr^c Sha/J

000306 STOCK Dll3^pu + Tyr^c-ch/+ Oca2^p Tyr^c-ch/J

000006 STOCK Hk Tyr^c/J

000206 STOCK a/a Tyr^c-h/J

View Strains carrying other alleles of Tyr (28 strains)

Additional Web Information

Congenic Nomenclature
Genetic Quality Control Annual Report

Research Applications

This mouse can be used to support research in many areas including:

Myo5a^d-l31J related

Developmental Biology Research
Postnatal Mortality (Homozygous)

Neurobiology Research
Ataxia (Movement) Defects

Tyr⁺ related

Dermatology Research
Color and White Spotting Defects (oculocutaneous albinism, type I)

Mouse/Human Gene Homologs
albinism, tyrosine negative (wildtype)

References

Additional References

Price and Supply Information

Strain Name:	*A.B6 Tyr⁺-Myo5a^d-l31J/J*
Stock Number:	005012

Price Details

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Supply Details

Standard Supply	Repository-Cryopreserved. Must Be Recovered. Please refer to the Supply Notes for further information.
Supply Notes	Cryorecovery of Strains Needing Progeny Testing. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two untested males and two untested females (two pairs) will be recovered, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the overall recovery time to approximately 25 weeks. However, all pups recovered will be sent. Progeny testing is required to identify the genotype of mice of this strain, as a genotyping assay is not available. This type of testing involves breeding the recovered animals and assessing the phenotype of the offspring in order to identify animals carrying the mutation of interest. We can perform the progeny testing for you as a service or we can ship all recovered animals (at least two untested pairs) to you for progeny testing at your facility. If you perform the progeny testing, there is NO guarantee that a carrier will be identified. If we perform progeny testing as a service, additional breeding time will be required. In this case, when a male and female (one pair) are identified that carry the mutation, they and their offspring will be shipped. Delivery time for strains requiring progeny testing often exceeds 25 weeks and may take 12 months or more due to the difficulties in breeding some strains. The progeny testing cost is in addition to the recovery cost and is based on the number of boxes used and the time taken to produce the mice identified as carrying the mutation. Please note that identified pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Please contact Customer Service for more information on the cost of progeny testing for a strain: Tel: 1-800-422-6423 or 1-207-288-5845. *Cryorecovery to establish a Dedicated Supply for greater quantities of mice* One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX^® Services: Tel: 1-800-422-6423 or 1-207-288-5845; Email: jaxservices@jax.org. This strain is included in the Mouse Heart, Lung, Blood and Sleep Disorders Center collection. Genomic DNA is available for this strain from the Mouse DNA Resource.
Licensing	See General Terms and Conditions below

General Terms and Conditions

View JAX^® Mice & Services Conditions of Use.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

Ordering and Purchasing Information

Purchasing Information
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Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form

Go to JAX^® Mice Query Form

000090	129S1/Sv-Oca2⁺ Tyr⁺ Kitl^Sl-J/J
005445	A.B6 Tyr⁺-Cyba^nmf333/J
002565	A.B6-Tyr⁺/J
000822	B6 x 129S1/SvEi Oca2⁺ Tyr⁺-Vsx2^or-J/J
000899	C.B6-Tyr⁺ Hbb^s/J
000494	J.Cg-Oca2⁺ Tyr⁺ Lyst^bg/J
002281	NFS.C58-Tyr⁺/J
004304	NOD.CBALs-Tyr⁺/LtJ

001013	B10.D2/nSnJ-Myo5a^d-n/J
000502	B6 x B6CBCa A^w-J/A-Myo5a^flr Gnb5^flr/J
000285	B6.Cg-Rora^sg + +/+ Myo5a^d Bmp5^se/J
000284	CWD/LeJ
000963	DBA/2J-Myo5a^d+17J/Myo5a^d/J
000964	DBA/2J-Myo5a^d+18J/Myo5a^d/J
000067	DBA/2J-Myo5a^d+2J/Myo5a^d/J
000253	DLS/LeJ
001850	MEV-Q/TyJ
001855	MEV-V/TyJ
003345	MEV/2Ty-Emv64/J
000390	STOCK Myo5a^d Ds/J
000994	STOCK a Myo5a^d Mreg^dsu/J
000286	STOCK a/a Myo5a^d fd/+ +/J

000091	129T1/Sv-Oca2⁺ Tyr^c-ch Dnd1^Ter/J
001279	129T1/Sv-Oca2⁺ Tyr^c-ch-Aft/J
000409	B10.129P-H1^b Hbb^d Tyr^c Ea7^a/(5M)oSnJ
000418	B10.129P-H1^b Tyr^c Hbb^d/(5M)nSnJ
000432	B10.C-H1^b Hbb^d Tyr^c/(41N)SnJ
000580	B10.D2/nSn-Tyr^c-4J/J
000578	B6 x STOCK Tyr^c-ch Bmp5^se +/+ Myo6^sv/J
000058	B6(Cg)-Tyr^c-2J/J
000383	B6.C-Tyr^c H1^b Hbb^d/ByJ
007484	B6.Cg-Tyr^c-2J Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ
000035	B6.Cg-Tyr^c-J/J
000104	B6.Cg-Tyr^c-h/J
000054	B6.D2-Tyr^c-p/J
000339	C3H/HeJ-Tyr^c-9J/J
001294	C3H/HeJ-Tyr^c-a/J
001002	C57BL/10SnJ-Tyr^c-11J/J
001006	CBA/J-Tyr^c-10J/J
000657	CE/J
000619	FS/EiJ
004828	FVB.129P2-Pde6b⁺ Tyr^c-ch/AntJ
007483	FVB.Cg-Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ
005115	NOD.FVB-Tg(INS-MT2A,Tyr)1Pne/PneJ
005114	NOD.FVB-Tg(Ins1-Cat,Tyr)25Pne/PneJ
000271	SH1/LeJ
001759	STOCK A Tyr^c Sha/J
000306	STOCK Dll3^pu + Tyr^c-ch/+ Oca2^p Tyr^c-ch/J
000006	STOCK Hk Tyr^c/J
000206	STOCK a/a Tyr^c-h/J

Strain Name:

A.B6 Tyr+-Myo5ad-l31J/J

Stock Number:

005012

Availability:

Repository-Cryopreserved

General Terms and Conditions

Product Information

Strain Details

Myo5ad-l31J/Myo5ad-l31J

Gene & Allele Details

Related Strains

Additional Web Information

Research Applications

References

Price and Supply Information

Price Details

*NO Shipping Destination selected!

Supply Details

General Terms and Conditions

The Jackson Laboratory's Genotype Promise

A.B6 Tyr⁺-Myo5a^d-l31J/J

Myo5a^d-l31J/Myo5a^d-l31J