JAX Mice Database - 005012 A.B6 Tyr<+>-Myo5a<d-l31J>/J

Strain Name:	A.B6 Tyr⁺-Myo5a^d-l31J/J
Stock Number:	005012
Availability:	Cryopreserved - Ready for recovery

Description
Phenotype
Genes & alleles
Genotyping
Health & husbandry
References
Purchasing information
Terms of Use

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names A.B6 Tyr⁺-nmf244/J (Changed: 28-MAR-06 )

NMF244 (Changed: 10-AUG-05 )

Type Chemically Induced Mutation; Congenic; Mutant Strain;
Additional information on Genetically Engineered and Mutant Mice.

Visit our online Nomenclature tutorial.

Additional information on Congenic nomenclature.

Species laboratory mouse

H2 Haplotype a

Generation N4F1+N1p (26-FEB-06)

Description
View strain phenotype and additional information on the Neuroscience Mutagenesis Facility web page.

Related Strains

Strains carrying Tyr⁺ allele

000090 129S1/Sv-Oca2⁺ Tyr⁺ Kitl^Sl-J/J

005445 A.B6 Tyr⁺-Cyba^nmf333/J

002565 A.B6-Tyr⁺/J

000822 B6 x 129S1/SvEi Oca2⁺ Tyr⁺-Vsx2^or-J/J

000899 C.B6-Tyr⁺ Hbb^s/J

000494 J.Cg-Oca2⁺ Tyr⁺ Lyst^bg/J

002281 NFS.C58-Tyr⁺/J

004304 NOD.CBALs-Tyr⁺/LtJ

View Strains carrying Tyr⁺ (8 strains)

Strains carrying other alleles of Myo5a

001005 AKXD1/TyJ

001003 AKXD11/TyJ

000765 AKXD13/TyJ

000779 AKXD14/TyJ

000954 AKXD15/TyJ

001093 AKXD18/TyJ

000776 AKXD2/TyJ

001062 AKXD21/TyJ

000947 AKXD22/TyJ

000949 AKXD25/TyJ

000764 AKXD27/TyJ

000959 AKXD3/TyJ

001013 B10.D2/nSnJ-Myo5a^d-n/J

000502 B6 x B6CBCa A^w-J/A-Myo5a^flr Gnb5^flr/J

000285 B6.Cg-Rora^sg + +/+ Myo5a^d Bmp5^se/J

000652 BDP/J

000036 BXD1/TyJ

000013 BXD16/TyJ

000015 BXD18/TyJ

000010 BXD19/TyJ

000077 BXD21/TyJ

000043 BXD22/TyJ

000081 BXD25/TyJ

006255 BXD25/TyJRwwJ

000029 BXD29-Tlr4^lps-2J/J

010981 BXD29/Ty

000037 BXD5/TyJ

000007 BXD6/TyJ

000084 BXD8/TyJ

000105 BXD9/TyJ

000284 CWD/LeJ

000670 DBA/1J

000671 DBA/2J

000963 DBA/2J-Myo5a^d+17J/Myo5a^d/J

000964 DBA/2J-Myo5a^d+18J/Myo5a^d/J

000067 DBA/2J-Myo5a^d+2J/Myo5a^d/J

000253 DLS/LeJ

000673 HRS/J

000674 I/LnJ

001850 MEV-Q/TyJ

001855 MEV-V/TyJ

003345 MEV/2Ty-Emv64/J

000679 P/J

000644 SEA/GnJ

000390 STOCK Myo5a^d Ds/J

000994 STOCK a Myo5a^d Mreg^dsu/J

000286 STOCK a/a Myo5a^d fd/+ +/J

View Strains carrying other alleles of Myo5a (47 strains)

Strains carrying other alleles of Tyr

000091 129T1/Sv-Oca2⁺ Tyr^c-ch Dnd1^Ter/J

001279 129T1/Sv-Oca2⁺ Tyr^c-ch-Aft/J

001017 AKXD10/TyJ

000765 AKXD13/TyJ

000954 AKXD15/TyJ

000958 AKXD16/TyJ

001093 AKXD18/TyJ

001062 AKXD21/TyJ

000947 AKXD22/TyJ

000969 AKXD24/TyJ

000777 AKXD6/TyJ

000763 AKXD9/TyJ

000409 B10.129P-H1^b Hbb^d Tyr^c Ea7^a/(5M)oSnJ

000418 B10.129P-H1^b Tyr^c Hbb^d/(5M)nSnJ

000432 B10.C-H1^b Hbb^d Tyr^c/(41N)SnJ

000580 B10.D2/nSn-Tyr^c-4J/J

000578 B6 x STOCK Tyr^c-ch Bmp5^se +/+ Myo6^sv/J

000058 B6(Cg)-Tyr^c-2J/J

000383 B6.C-Tyr^c H1^b Hbb^d/ByJ

007484 B6.Cg-Tyr^c-2J Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ

000035 B6.Cg-Tyr^c-J/J

000104 B6.Cg-Tyr^c-h/J

000054 B6.D2-Tyr^c-p/J

000339 C3H/HeJ-Tyr^c-9J/J

001294 C3H/HeJ-Tyr^c-a/J

001002 C57BL/10SnJ-Tyr^c-11J/J

001006 CBA/J-Tyr^c-10J/J

000657 CE/J

000619 FS/EiJ

004828 FVB.129P2-Pde6b⁺ Tyr^c-ch/AntJ

007483 FVB.Cg-Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ

005115 NOD.FVB-Tg(INS-MT2A,Tyr)1Pne/PneJ

005114 NOD.FVB-Tg(Ins1-Cat,Tyr)25Pne/PneJ

000271 SH1/LeJ

001759 STOCK A Tyr^c Sha/J

000306 STOCK Dll3^pu + Tyr^c-ch/+ Oca2^p Tyr^c-ch/J

000006 STOCK Hk Tyr^c/J

000206 STOCK a/a Tyr^c-h/J

View Strains carrying other alleles of Tyr (38 strains)

Additional Web Information

Genetic Quality Control Annual Report

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms
assigned by genotype

Myo5a^d-l31J/Myo5a^d-l31J
involves: A.B6-Tyr⁺
life span-post-weaning/aging

premature death (MGI Ref ID J:87349)

mice are fragile and usually die by or before 5 weeks of age

behavior/neurological phenotype

abnormal voluntary movement (MGI Ref ID J:87349)

impaired hind limb movements

they show 'hot-foot' like behavior of one or both limbs

impaired balance (MGI Ref ID J:87349)

mice intermittently lean to the side, fall over, but are able to regain their walking position

growth/size phenotype

decreased body size (MGI Ref ID J:87349)

animals are small

pigmentation phenotype

abnormal coat/hair pigmentation (MGI Ref ID J:87349)

mice exhibit a non-agouti grey coat color that appears to result from a non-agouti grey allele that is known to exist in heterozygotes for the dilute-lethal allele of Myo5a, and becomes apparent in the presence of the agouti dilute allele, carried by the female NMF244

skin/coat/nails phenotype

abnormal coat/hair pigmentation (MGI Ref ID J:87349)

mice exhibit a non-agouti grey coat color that appears to result from a non-agouti grey allele that is known to exist in heterozygotes for the dilute-lethal allele of Myo5a, and becomes apparent in the presence of the agouti dilute allele, carried by the female NMF244

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Neurobiology Research
Neuroscience Mutagenesis Facility Strain

Myo5a^d-l31J related

Developmental Biology Research
Postnatal Mortality
Homozygous

Neurobiology Research
Ataxia (Movement) Defects

Tyr⁺ related

Dermatology Research
Color and White Spotting Defects
oculocutaneous albinism, type I

Mouse/Human Gene Homologs
albinism, tyrosine negative
wildtype

Genes & Alleles

Gene & Allele Information


Allele Symbol		Myo5a^d-l31J
Allele Name		dilute lethal 31 Jackson
Allele Type		Chemically induced (ENU)
Common Name(s)		Myo5a^nmf244; NMF244; neuroscience mutagenesis facility, 244;
Strain of Origin		A.B6-Tyr⁺
Gene Symbol and Name		Myo5a, myosin VA
Chromosome		9
Gene Common Name(s)		9630007J19Rik; AI413174; AI661011; D; Dbv; Dop; GS1; MVa; MYH12; MYO5; MYR12; Myo5; MyoVA; RIKEN cDNA 9630007J19 gene; d; dilute; expressed sequence AI413174; expressed sequence AI661011; flail; flailer; flr; myosin V; nmf244;
Molecular Note		This phenotypic mutant was identified in an ENU mutagenesis screen. Complementation tests between heterozygous NMF244 and DLS/LeJ mice produced six affected mice in a total of 22 progeny, suggesting that NMF244 represents a new allele of dilute-lethal inthis gene.

Allele Symbol		Tyr⁺
Allele Name		wild type
Allele Type		Not Applicable
Gene Symbol and Name		Tyr, tyrosinase
Chromosome		7
Gene Common Name(s)		OCA1A; OCAIA; SHEP3; albino; c; skc35; skin/coat color 35;

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Genotyping resources and troubleshooting

References

Additional References

Myo5a^d-l31J related

JAX Neuroscience Mutagenesis Facility URL: http://www.jax.org/nmf. 2004. Heritable mouse mutants from JAX NMF ENU Mutagenesis Program MGI Direct Data Submission :. [MGI Ref ID J:87349]

Tyr⁺ related

Lossie AC; Nakamura H; Thomas SE; Justice MJ. 2005. Mutation of l7Rn3 shows that Odz4 is required for mouse gastrulation. Genetics 169(1):285-99. [PubMed: 15489520] [MGI Ref ID J:96673]

Miller DA; Dev VG; Tantravahi R; Miller OJ; Schiffman MB; Yates RA; Gluecksohn-Waelsch S. 1974. Cytological detection of the c-25H deletion involving the albino (c) locus on chromosome 7 in the mouse. Genetics 78(3):905-10. [PubMed: 4141683] [MGI Ref ID J:5520]

Sweet HO. 1987. Acromelanic (c<a>) Mouse News Lett 78:56. [MGI Ref ID J:14994]

Health & husbandry

Health & Colony Maintenance Information

Currently there no information available for this strain. This may be due to the supply level of this strain.

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations

Price (US dollars $)

Cryorecovery Fee $1900.00

Animals Provided
At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

	Price (US dollars $)
Cryorecovery Fee	$1900.00

Additional Supply Details

Pricing for International shipping destinations

Price (US dollars $)

Cryorecovery Fee $2470.00

Animals Provided
At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

	Price (US dollars $)
Cryorecovery Fee	$2470.00

Additional Supply Details

Supply Details

Standard Supply	Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
Supply Notes	Cryorecovery - Strains Requiring Specialized Phenotyping. At least two untested males and two untested females (two pairs) will be recovered from cryopreserved stocks and will require specialized phenotyping in order to identify animals carrying the mutation of interest. We do not perform the phenotyping for this strain. Upon completion of the cryorecovery process, we will ship you all of the recovered mice (a minimum of two pair, typically eight or more). We *cannot guarantee* that you will receive or be able to identify animals of the phenotype of interest. Please be advised that a new order and cryorecovery fee will be necessary to recover additional mice, if needed. The typical cryorecovery period required is 10 weeks. However, because recovery efficiency and viability can vary, a second cryorecovery sometimes may be required in order to complete this order, which may extend the time for order completion to 15 to 20 weeks. If this situation occurs, we will notify you of the delay. Please note that identified pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Please contact Customer Service for more information: Tel: 1-800-422-6423 (from U.S.A., Canada and Puerto Rico only) or 1-207-288-5845 (from any location). The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary. This strain is included in the Mouse Mutant Resource collection. Genomic DNA is available for this strain from the Mouse DNA Resource.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.

Supply Notes

Cryorecovery - Strains Requiring Specialized Phenotyping.
At least two untested males and two untested females (two pairs) will be recovered from cryopreserved stocks and will require specialized phenotyping in order to identify animals carrying the mutation of interest. We do not perform the phenotyping for this strain. Upon completion of the cryorecovery process, we will ship you all of the recovered mice (a minimum of two pair, typically eight or more). We cannot guarantee that you will receive or be able to identify animals of the phenotype of interest. Please be advised that a new order and cryorecovery fee will be necessary to recover additional mice, if needed. The typical cryorecovery period required is 10 weeks. However, because recovery efficiency and viability can vary, a second cryorecovery sometimes may be required in order to complete this order, which may extend the time for order completion to 15 to 20 weeks. If this situation occurs, we will notify you of the delay. Please note that identified pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Please contact Customer Service for more information: Tel: 1-800-422-6423 (from U.S.A., Canada and Puerto Rico only) or 1-207-288-5845 (from any location). The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.
This strain is included in the Mouse Mutant Resource collection.
Genomic DNA is available for this strain from the Mouse DNA Resource.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

Ordering and Purchasing Information

Purchasing Information
JAX^® Mice Orders
Surgical Services

Contact Information
Orders & Technical Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

General Terms and Conditions

Contact information

General inquiries

Contracts Administration

phone:	207-288-6470
fax:	207-288-6655

JAX^® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. In purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.

000090	129S1/Sv-Oca2⁺ Tyr⁺ Kitl^Sl-J/J
005445	A.B6 Tyr⁺-Cyba^nmf333/J
002565	A.B6-Tyr⁺/J
000822	B6 x 129S1/SvEi Oca2⁺ Tyr⁺-Vsx2^or-J/J
000899	C.B6-Tyr⁺ Hbb^s/J
000494	J.Cg-Oca2⁺ Tyr⁺ Lyst^bg/J
002281	NFS.C58-Tyr⁺/J
004304	NOD.CBALs-Tyr⁺/LtJ

001005	AKXD1/TyJ
001003	AKXD11/TyJ
000765	AKXD13/TyJ
000779	AKXD14/TyJ
000954	AKXD15/TyJ
001093	AKXD18/TyJ
000776	AKXD2/TyJ
001062	AKXD21/TyJ
000947	AKXD22/TyJ
000949	AKXD25/TyJ
000764	AKXD27/TyJ
000959	AKXD3/TyJ
001013	B10.D2/nSnJ-Myo5a^d-n/J
000502	B6 x B6CBCa A^w-J/A-Myo5a^flr Gnb5^flr/J
000285	B6.Cg-Rora^sg + +/+ Myo5a^d Bmp5^se/J
000652	BDP/J
000036	BXD1/TyJ
000013	BXD16/TyJ
000015	BXD18/TyJ
000010	BXD19/TyJ
000077	BXD21/TyJ
000043	BXD22/TyJ
000081	BXD25/TyJ
006255	BXD25/TyJRwwJ
000029	BXD29-Tlr4^lps-2J/J
010981	BXD29/Ty
000037	BXD5/TyJ
000007	BXD6/TyJ
000084	BXD8/TyJ
000105	BXD9/TyJ
000284	CWD/LeJ
000670	DBA/1J
000671	DBA/2J
000963	DBA/2J-Myo5a^d+17J/Myo5a^d/J
000964	DBA/2J-Myo5a^d+18J/Myo5a^d/J
000067	DBA/2J-Myo5a^d+2J/Myo5a^d/J
000253	DLS/LeJ
000673	HRS/J
000674	I/LnJ
001850	MEV-Q/TyJ
001855	MEV-V/TyJ
003345	MEV/2Ty-Emv64/J
000679	P/J
000644	SEA/GnJ
000390	STOCK Myo5a^d Ds/J
000994	STOCK a Myo5a^d Mreg^dsu/J
000286	STOCK a/a Myo5a^d fd/+ +/J

000091	129T1/Sv-Oca2⁺ Tyr^c-ch Dnd1^Ter/J
001279	129T1/Sv-Oca2⁺ Tyr^c-ch-Aft/J
001017	AKXD10/TyJ
000765	AKXD13/TyJ
000954	AKXD15/TyJ
000958	AKXD16/TyJ
001093	AKXD18/TyJ
001062	AKXD21/TyJ
000947	AKXD22/TyJ
000969	AKXD24/TyJ
000777	AKXD6/TyJ
000763	AKXD9/TyJ
000409	B10.129P-H1^b Hbb^d Tyr^c Ea7^a/(5M)oSnJ
000418	B10.129P-H1^b Tyr^c Hbb^d/(5M)nSnJ
000432	B10.C-H1^b Hbb^d Tyr^c/(41N)SnJ
000580	B10.D2/nSn-Tyr^c-4J/J
000578	B6 x STOCK Tyr^c-ch Bmp5^se +/+ Myo6^sv/J
000058	B6(Cg)-Tyr^c-2J/J
000383	B6.C-Tyr^c H1^b Hbb^d/ByJ
007484	B6.Cg-Tyr^c-2J Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ
000035	B6.Cg-Tyr^c-J/J
000104	B6.Cg-Tyr^c-h/J
000054	B6.D2-Tyr^c-p/J
000339	C3H/HeJ-Tyr^c-9J/J
001294	C3H/HeJ-Tyr^c-a/J
001002	C57BL/10SnJ-Tyr^c-11J/J
001006	CBA/J-Tyr^c-10J/J
000657	CE/J
000619	FS/EiJ
004828	FVB.129P2-Pde6b⁺ Tyr^c-ch/AntJ
007483	FVB.Cg-Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ
005115	NOD.FVB-Tg(INS-MT2A,Tyr)1Pne/PneJ
005114	NOD.FVB-Tg(Ins1-Cat,Tyr)25Pne/PneJ
000271	SH1/LeJ
001759	STOCK A Tyr^c Sha/J
000306	STOCK Dll3^pu + Tyr^c-ch/+ Oca2^p Tyr^c-ch/J
000006	STOCK Hk Tyr^c/J
000206	STOCK a/a Tyr^c-h/J

Strain Name:

A.B6 Tyr+-Myo5ad-l31J/J

Stock Number:

005012

Availability:

Cryopreserved - Ready for recovery

Strain Information

Related Strains

Additional Web Information

Phenotype Information

Myo5ad-l31J/Myo5ad-l31J

Gene & Allele Information

Genotyping Information

Helpful Links

References

Additional References

Health & Colony Maintenance Information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Additional Supply Details

Additional Supply Details

Supply Details

Payment Terms and Conditions

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

Terms of Use

Contact information

Contracts Administration

JAX® Mice, Products & Services Conditions of Use

No Warranty

No Liability

A.B6 Tyr⁺-Myo5a^d-l31J/J

Myo5a^d-l31J/Myo5a^d-l31J

JAX^® Mice, Products & Services Conditions of Use