Strain Name:

B6;129-Tdrd7nmf166/J

Stock Number:

005043

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Availability:

Cryopreserved - Ready for recovery

Common Names: NMF166;    

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names B6;129-nmf166/J    (Changed: 15-MAR-13 )
Type Chemically Induced Mutation; Mutant Stock;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse
H2 Haplotypeb

Appearance
black
Related Genotype: a/a

Description
Routine eye examination at 12 weeks of age revealed deep anterior chambers, lens extrusion cataracts, and angle dysgenesis in NMF166 mutants (n=29 eyes examined). Standard pathology work-up on two mutants (84 or 90 days of age) revealed bilateral cataracts and retinal rosettes. Atrophic testes and a lack of sperm (sperm apoptosis in the epididymis) were also noted. Male or female mutants have been produced, although so far males have not mated successfully.

Development
This phenotypic deviant was generated by ethylmethanesulfonate (EMS) mutagenesis in the Neuroscience Mutagenesis facility at The Jackson Laboratory.

Control Information

  Control
   +/? littermate
 
  Considerations for Choosing Controls

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Cataract 36; CTRCT36   (TDRD7)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Tdrd7nmf166/Tdrd7nmf166

        B6;129-Tdrd7nmf166/J
  • vision/eye phenotype
  • abnormal eye anterior chamber morphology
    • eye examination at 12 weeks of age revealed deep anterior chambers   (MGI Ref ID J:87349)
  • cataracts
    • eye examination at 12 weeks of age revealed lens extrusion cataracts   (MGI Ref ID J:87349)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Tdrd7nmf166/Tdrd7nmf166

        involves: C3H * C57BL/6J
  • vision/eye phenotype
  • abnormal iris morphology
    • iris flattening is detected by 4 months of age   (MGI Ref ID J:169836)
  • abnormal lens morphology
    • lens extrusion at later stages   (MGI Ref ID J:169836)
    • in some cases the mass of fiber cells pass through the pupil into the anterior chamber of the eye   (MGI Ref ID J:169836)
    • abnormal lens fiber morphology
      • develop vacuoles at later stages   (MGI Ref ID J:169836)
    • cataracts
      • all develop posterior cataracts by 4 weeks of age that become more severe with age   (MGI Ref ID J:169836)
    • ruptured lens capsule
      • rupture and extrusion of fiber cell mass into the vitreous at later stages   (MGI Ref ID J:169836)
  • enlarged eye anterior chamber
    • increased depth is seen by 4 months of age   (MGI Ref ID J:169836)
  • ocular hypertension
    • detected in some mice by 6 months of age   (MGI Ref ID J:169836)
    • incidence increases with age   (MGI Ref ID J:169836)
  • optic neuropathy
    • severe optic nerve atrophy characterized by retinal ganglion cell axon loss and excavative remodeling of the optic nerve are seen   (MGI Ref ID J:169836)
  • uveitis
    • posterior uveitis in 2 mice at 0ver 24 months of age   (MGI Ref ID J:169836)
  • reproductive system phenotype
  • arrest of spermatogenesis
    • arrests at the round spermatid stage   (MGI Ref ID J:169836)
  • male infertility   (MGI Ref ID J:169836)
  • nervous system phenotype
  • optic neuropathy
    • severe optic nerve atrophy characterized by retinal ganglion cell axon loss and excavative remodeling of the optic nerve are seen   (MGI Ref ID J:169836)
  • immune system phenotype
  • uveitis
    • posterior uveitis in 2 mice at 0ver 24 months of age   (MGI Ref ID J:169836)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Developmental Biology Research
Eye Defects

Sensorineural Research
Cataracts
      lens extrusion

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Tdrd7nmf166
Allele Name neuroscience mutagenesis facility, 166
Allele Type Chemically induced (ENU)
Common Name(s) NMF166; Tdrd7glcr5; Tdrd7grm5;
Strain of OriginC57BL/6J
Gene Symbol and Name Tdrd7, tudor domain containing 7
Chromosome 4
Gene Common Name(s) 5730495N10Rik; AI447470; CATC4; PCTAIRE2BP; RIKEN cDNA 5730495N10 gene; TRAP; expressed sequence AI447470;
Molecular Note ENU induced a C to T nonsense mutation at position 2187 in the coding region resulting in glutamine to stop mutation at amino acid 723. Western blot analysis did not detect any protein expression in the eyes from homozygous mice indicating this is a nullallele. [MGI Ref ID J:169836] [MGI Ref ID J:68708]

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Tdrd7nmf166 related

Hrabe de Angelis MH; Flaswinkel H; Fuchs H; Rathkolb B; Soewarto D; Marschall S; Heffner S; Pargent W; Wuensch K; Jung M; Reis A; Richter T; Alessandrini F; Jakob T; Fuchs E; Kolb H; Kremmer E; Schaeble K; Rollinski B; Roscher A; Peters C; Meitinger T; Strom T; Steckler T; Holsboer F; Klopstock T; Gekeler F; Schindewolf C; Jung T; Avraham K; Behrendt H; Ring J; Zimmer A; Schughart K; Pfeffer K; Wolf E; Balling R. 2000. Genome-wide, large-scale production of mutant mice by ENU mutagenesis. Nat Genet 25(4):444-7. [PubMed: 10932192]  [MGI Ref ID J:68708]

JAX Neuroscience Mutagenesis Facility. 2004. Heritable mouse mutants from JAX NMF ENU Mutagenesis Program MGI Direct Data Submission :.  [MGI Ref ID J:87349]

Lachke SA; Alkuraya FS; Kneeland SC; Ohn T; Aboukhalil A; Howell GR; Saadi I; Cavallesco R; Yue Y; Tsai AC; Nair KS; Cosma MI; Smith RS; Hodges E; Alfadhli SM; Al-Hajeri A; Shamseldin HE; Behbehani A; Hannon GJ; Bulyk ML; Drack AV; Anderson PJ; John SW; Maas RL. 2011. Mutations in the RNA granule component TDRD7 cause cataract and glaucoma. Science 331(6024):1571-6. [PubMed: 21436445]  [MGI Ref ID J:169836]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2525.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Strains Requiring Specialized Phenotyping.
    At least two untested males and two untested females (two pairs) will be recovered from cryopreserved stocks and will require specialized phenotyping in order to identify animals carrying the mutation of interest. We do not perform the phenotyping for this strain. Untested animals typically are available to ship between 10 and 14 weeks from the date of your order. We will ship you all of the recovered mice (a minimum of two pair, typically eight or more). We cannot guarantee that you will receive or be able to identify animals of the phenotype of interest. Please be advised that a new order and cryorecovery fee will be necessary to recover additional mice, if needed. Because recovery efficiency and viability can vary, a second cryorecovery sometimes may be required in order to complete this order, which may extend the time for order completion to 25 weeks. If this situation occurs, we will notify you of the delay. Please note that identified pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation.

    Please contact Customer Service for more information: Tel: 1-800-422-6423 (from U.S.A., Canada and Puerto Rico only) or 1-207-288-5845 (from any location). The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3283.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Strains Requiring Specialized Phenotyping.
    At least two untested males and two untested females (two pairs) will be recovered from cryopreserved stocks and will require specialized phenotyping in order to identify animals carrying the mutation of interest. We do not perform the phenotyping for this strain. Untested animals typically are available to ship between 10 and 14 weeks from the date of your order. We will ship you all of the recovered mice (a minimum of two pair, typically eight or more). We cannot guarantee that you will receive or be able to identify animals of the phenotype of interest. Please be advised that a new order and cryorecovery fee will be necessary to recover additional mice, if needed. Because recovery efficiency and viability can vary, a second cryorecovery sometimes may be required in order to complete this order, which may extend the time for order completion to 25 weeks. If this situation occurs, we will notify you of the delay. Please note that identified pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation.

    Please contact Customer Service for more information: Tel: 1-800-422-6423 (from U.S.A., Canada and Puerto Rico only) or 1-207-288-5845 (from any location). The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   +/? littermate
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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