Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Chemically Induced Mutation; Mutant Stock; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation N3F1+N1p (10-JUL-05) Generation Definitions

Description
View strain phenotype and additional information on the Neuroscience Mutagenesis Facility web page for nmf299 entry.

Control Information

	Control
	+/? from the colony
Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of Cacna2d2

012889	B6N;TKDU-Myo5ad Cacna2d2du/J
008625	C57BLKS/J-Cacna2d2du-2J/LetJ

View Strains carrying other alleles of Cacna2d2     (2 strains)

Additional Web Information

Genetic Quality Control Annual Report

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI

      assigned by genotype

Cacna2d2^du-3J/Cacna2d2^du-3J

        involves: BALB/cByJ * C57BL/6J

• mortality/aging
• premature death
  • with special care and feeding, homozygotes may survive until older than two months; otherwise, some die as young as 4 weeks of age   (MGI Ref ID J:82238)
• behavior/neurological phenotype
• abnormal motor coordination/ balance
  • from about 5 weeks of age, mutant mice keep their hindlimbs splayed   (MGI Ref ID J:82238)
• myoclonus
  • from approximately 5 weeks of age, mutant mice exhibit intermittent spasms affecting one or both hind- or forelimbs, the head, neck, shoulder and forelimb region, or the entire body; in the last case, the mouse must lie on its side   (MGI Ref ID J:82238)
• tremors
  • body tremor is apparent by approximately 12 days   (MGI Ref ID J:82238)
• growth/size phenotype
• decreased body size
  • obvious by approximately 12 days; both body and internal organs of a 57 day-old homozygous mouse were found on pathological examination to be small and immature   (MGI Ref ID J:82238)
• muscle phenotype
• myoclonus
  • from approximately 5 weeks of age, mutant mice exhibit intermittent spasms affecting one or both hind- or forelimbs, the head, neck, shoulder and forelimb region, or the entire body; in the last case, the mouse must lie on its side   (MGI Ref ID J:82238)
• reproductive system phenotype
• *normal* reproductive system phenotype
  • homozygous females may be able to "breed" only via transplantation of their ovaries to other hosts, however males are fertile   (MGI Ref ID J:82238)
• nervous system phenotype
• myoclonus
  • from approximately 5 weeks of age, mutant mice exhibit intermittent spasms affecting one or both hind- or forelimbs, the head, neck, shoulder and forelimb region, or the entire body; in the last case, the mouse must lie on its side   (MGI Ref ID J:82238)

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Developmental Biology Research
Neurodevelopmental Defects

Neurobiology Research
Ataxia (Movement) Defects
Neurodevelopmental Defects

Cacna2d2^du-3J related

Cell Biology Research
Channel and Transporter Defects
      calcium

Neurobiology Research
Channel and Transporter Defects
      calcium
Neuroscience Mutagenesis Facility Strain

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol		Cacna2d2du-3J
Allele Name		ducky 3 Jackson
Allele Type		Chemically induced (ENU)
Common Name(s)		Cacna2d2nmf299; NMF299; neuroscience mutagenesis facility, 299;
Strain of Origin		C57BL/6J
Gene Symbol and Name		Cacna2d2, calcium channel, voltage-dependent, alpha 2/delta subunit 2
Chromosome		9
Gene Common Name(s)		CACNA2D; LUAC11.1; a2d2; du; ducky; nmf299; td; torpid;
Molecular Note		This phenotypic mutation, identified in an ENU mutagenesis screen, was shown by complementation testing to be an allele of Cacna2d2.

Genotyping

Genotyping Information

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Cacna2d2^du-3J related

JAX Neuroscience Mutagenesis Facility. 2003. Heritable mouse mutants from JAX NMF ENU Mutagenesis Program MGI Direct Data Submission :.  [MGI Ref ID J:82238]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, RG10/RG30.

Purchasing information

Pricing, Supply Level & Notes, Controls

General Supply Notes

• This strain is included in the Neuroscience Mutagenesis Facility (NMF).
• Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

	Control
	+/? from the colony
Considerations for Choosing Controls
Control Pricing Information for Genetically Engineered Mutant Strains.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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