Strain Name:

STOCK KitW-sh/HNihrJaeBsmJ

Stock Number:

005051

Order this mouse

Availability:

Repository- Live

Other products are available, see Purchasing Information for Cryopreserved Embryos

These mice carry the spontaneous Kit "sash" mutation associated with melanogenesis and mast cell deficiency.

Description

Strain Information

Former Names B6.Cg-KitW-sh/HNihrJaeBsmJ    (Changed: 20-MAY-10 )
C57BL/6J-KitW-sh/BsmJ    (Changed: 15-DEC-04 )
Type Mutant Stock; Spontaneous Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Specieslaboratory mouse
Background Strain C57BL/6
Donor Strain (C3H/HeH x 101/H)F1
GenerationN15F1+F17 (17-JUL-13)
Generation Definitions

Appearance
black with white sash at midline, black eyes
Related Genotype: a/a KitW-sh/+

Important Note
In 2010, The Jackson Laboratory performed a 126 single nucleotide polymorphism analysis on all pedigree lines of KitW-sh mice from Stock No. 005051. This revealed 14/126 markers that were homozygous C3H/He allele-type (two on Chr 5 [including the marker at 76.4 Mbp; closest to the Kit locus], three on Chr 6, one on Chr 8, two on Chr 12, two on Chr 13, one on Chr 15, two on Chr 16, one on Chr 18). Additionally, two markers were segregating for C57BL/6 and C3H/He allele-type (one on Chr 6, one on Chr 16). The amount of 101/H markers present (if any) was not determined. These data show Stock No. 005051 to be only ~87% C57BL/6-genetic background; and suggests it was not completely backcrossed to C57BL/6 prior to arrival in 2004. Therefore, we also offer a fully C57BL/6J-congenic KitW-sh model (Stock No. 012861) for studying KitW-sh on a C57BL/6J genetic background.

Description
The sash mutation results in an embryonic deficit and eventual abolishment of mast cells soon after birth. There is also a deficit of melanocytes and interstitial cells in these mice. Reduced numbers of melanocytes results in some hearing impairment in homozygotes. The KitW-sh mutation is a inversion in regulatory elements upstream of the c-kit element. Homozygotes are white with black eyes and some pigment around the ears. Heterozygotes are black with a white sash at the midline. The mice are fertile and not anemic.
    Recent findings of altered immune responses as a result of mast cell deficit in these mice include:
   •   heightened susceptibility to vaccinia virus skin infection;
   •   earlier and more severe experimental autoimmune encephalomyelitis disease (a model of multiple sclerosis) with extensive demyelination and inflammation in the CNS;
   •   exacerbated dermatitis upon repeated oxazolone challenge when compared to their wild-type;
   •   Ultra violet exposure in these mice does not induce immune suppression, as it does in wild type mice;
   •   lower serum IgE levels compared with wild-type mice under steady-state conditions and after N. brasiliensis (hookworm) infection;
   •   failure to elicit histamine release or contractile responses in trachea isolated from ovalbumin sensitized mast cell-deficient mice;
   •   development of 50% more adenomas than littermate controls and with tumors being 33% larger in KitW-sh mice;
   •   increased resistance to bacterial lipopolysaccharide injection;
   •   failure of ovalbumin sensitization to elicit histamine release or contractile responses in trachea isolated from sensitized KitW-sh mice.

Development
The KitW-sh (or "sash") mutation arose spontaneously on a litter produced from a C3H/HeH x 101/H mating at the MRC Radiobiology Unit at Harwell (H) in the U. K. (Lyon and Glenister 1982 Genet Res 39:315). The founder female was identified by a white sash around her midsection. The KitW-sh mutation is an inversion spanning a 2.8 Mbp segment proximal to the Kit locus that disrupts 5' regulatory sequences. The KitW-sh strain was transferred to Dr. Karen Steel (Nihr) also at Harwell, then to Dr. Rudolf Jaenisch (Jae) at MIT, and then to Dr. Peter Besmer (Bsm) at Sloan Kettering. Prior to the transfer to Dr. Besmer, this strain was reported to be backcrossed at least ten times to C57BL/6. Dr. Besmer donated the strain to The Jackson Laboratory Repository in 2004 (as Stock No. 005051). Upon arrival, the colony was maintained by breeding KitW-sh mice together.

In 2010, a 126 SNP (single nucleotide polymorphism) panel analysis representing all pedigree lines was performed by The Jackson Laboratory Repository. This revealed 14/126 markers that were homozygous C3H/He allele-type (two on chromosome 5 [including the marker at 76.4 Mbp; closest to the Kit locus], three on chromosome 6, one on chromosome 8, two on chromosome 12, two on chromosome 13, one on chromosome 15, two on chromosome 16, and one on chromosome 18). Additionally, 2/126 markers were segregating between C57BL/6 and C3H/He allele-type (one on chromosome 6 and one on chromosome 16). The amount of 101/H markers still present (if any) was not determined. These data show the mice to be only ~87% C57BL/6-genetic background, and suggest the mice were not completely backcrossed to C57BL/6 prior to arrival at The Jackson Laboratory Repository in 2004.

Control Information

  Control
   000664 C57BL/6J (approximate)
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   KitW-sh allele
012861   B6.Cg-KitW-sh/HNihrJaeBsmGlliJ
View Strains carrying   KitW-sh     (1 strain)

View Strains carrying other alleles of Kit     (40 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Gastrointestinal Stromal Tumor; GIST   (KIT)
Mast Cell Disease   (KIT)
Piebald Trait; PBT   (KIT)
Testicular Germ Cell Tumor; TGCT   (KIT)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

KitW-sh/Kit+

        involves: 101/H * C3H/HeH * CBA
  • pigmentation phenotype
  • variable body spotting
    • appears as a distinctive broad white sash   (MGI Ref ID J:24351)
  • integument phenotype
  • variable body spotting
    • appears as a distinctive broad white sash   (MGI Ref ID J:24351)

KitW-sh/KitW-sh

        involves: 101/H * C3H/HeH
  • immune system phenotype
  • decreased mast cell degranulation
    • following chloroquine treatment   (MGI Ref ID J:157470)
  • decreased mast cell number
    • mice are described as being mast cell deficient   (MGI Ref ID J:145444)
  • increased susceptibility to parasitic infection
    • after second infestation to ticks, mice fail to exhibit resistance (repletion) unlike similarly treated wild-type mice   (MGI Ref ID J:163761)
    • however, transfer of wild-type bone marrow restores repletion   (MGI Ref ID J:163761)
  • pigmentation phenotype
  • abnormal coat/hair pigmentation
    • the coat is white except for small patches on or near the ears and, infrequently, at the base of the tail   (MGI Ref ID J:6857)
  • behavior/neurological phenotype
  • impaired behavioral response to xenobiotic
    • mice exhibit reduced chloroquine-induced scratching compared with similarly treated wild-type mice   (MGI Ref ID J:157470)
  • hematopoietic system phenotype
  • abnormal hematopoiesis   (MGI Ref ID J:6857)
    • abnormal erythrocyte cell number   (MGI Ref ID J:6857)
      • decreased erythrocyte cell number
        • on this background,lower than normal mean hematocrit values were found but did not manifest as an anemia   (MGI Ref ID J:6857)
    • decreased mast cell number
      • mice are described as being mast cell deficient   (MGI Ref ID J:145444)
  • decreased mast cell degranulation
    • following chloroquine treatment   (MGI Ref ID J:157470)
  • integument phenotype
  • abnormal coat/hair pigmentation
    • the coat is white except for small patches on or near the ears and, infrequently, at the base of the tail   (MGI Ref ID J:6857)

KitW-sh/KitW-sh

        involves: 101/H * C3H/HeH * CBA
  • integument phenotype
  • absent coat pigmentation
    • classic black eyes and white coat   (MGI Ref ID J:24351)
  • pigmentation phenotype
  • absent coat pigmentation
    • classic black eyes and white coat   (MGI Ref ID J:24351)

KitW-sh/KitW-sh

        involves: C57BL/6J
  • immune system phenotype
  • decreased susceptibility to type I hypersensitivity reaction
    • following intradermally injection of BV-PLA2 or PLA2G3 into the mouse ear, mice fail to exhibit IgE and antigen induced dose-dependent vascular leakage or augmented passive cutaneous anaphylaxis unlike wild-type mice   (MGI Ref ID J:197334)
  • cardiovascular system phenotype
  • abnormal vascular permeability
    • following intradermally injection of BV-PLA2 or PLA2G3 into the mouse ear, mice fail to exhibit IgE and antigen induced dose-dependent vascular leakage or augmented passive cutaneous anaphylaxis unlike wild-type mice   (MGI Ref ID J:197334)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Sensorineural Research
Hearing Defects

KitW-sh related

Dermatology Research
Color and White Spotting Defects

Immunology, Inflammation and Autoimmunity Research
Immunodeficiency
      Mast Cell Deficiency

Research Tools
Immunology, Inflammation and Autoimmunity Research
      Mast Cell Deficiency

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol KitW-sh
Allele Name sash
Allele Type Spontaneous
Common Name(s) Sash; W-sh; Wsh; Wsh;
Strain of Origin(C3H/HeH x 101/H)F1
Gene Symbol and Name Kit, kit oncogene
Chromosome 5
Gene Common Name(s) Bs; C-Kit; CD117; Dominant white spotting; Fdc; Gsfsco1; Gsfsco5; Gsfsow3; PBT; SCFR; SCO1; SCO5; SOW3; Ssm; Steel Factor Receptor; Tr-kit; W; belly-spot; dominant spotting; gsf spotted coat 1; gsf spotted coat 5; phenotype like Sl or W 3; spotted sterile male;
Molecular Note The molecular mutation of this allele is an inversion located proximal to the Kit structural gene that disrupts 5' regulatory sequences. Transcripts were not detectable from this allele in cultured mast cells derived from homozygous mice. However, an analysis of embryonic expression revealed that ectopic expression of Kit occurred in homozygous mice and normal expression was ablated. [MGI Ref ID J:13166] [MGI Ref ID J:25082] [MGI Ref ID J:2535] [MGI Ref ID J:29686] [MGI Ref ID J:6857]

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Berrozpe G; Timokhina I; Yukl S; Tajima Y; Ono M; Zelenetz AD; Besmer P. 1999. The W(sh), W(57), and Ph Kit expression mutations define tissue-specific control elements located between -23 and -154 kb upstream of Kit. Blood 94(8):2658-66. [PubMed: 10515869]  [MGI Ref ID J:109894]

Cable J; Huszar D; Jaenisch R; Steel KP. 1994. Effects of mutations at the W locus (c-kit) on inner ear pigmentation and function in the mouse. Pigment Cell Res 7(1):17-32. [PubMed: 7521050]  [MGI Ref ID J:21178]

Cable J; Jackson IJ; Steel KP. 1995. Mutations at the W locus affect survival of neural crest-derived melanocytes in the mouse. Mech Dev 50(2-3):139-50. [PubMed: 7619726]  [MGI Ref ID J:24351]

Duttlinger R; Manova K; Berrozpe G; Chu TY; DeLeon V; Timokhina I; Chaganti RS; Zelenetz AD; Bachvarova RF; Besmer P. 1995. The Wsh and Ph mutations affect the c-kit expression profile: c-kit misexpression in embryogenesis impairs melanogenesis in Wsh and Ph mutant mice. Proc Natl Acad Sci U S A 92(9):3754-8. [PubMed: 7537375]  [MGI Ref ID J:25082]

Duttlinger R; Manova K; Chu TY; Gyssler C; Zelenetz AD; Bachvarova RF; Besmer P. 1993. W-sash affects positive and negative elements controlling c-kit expression: ectopic c-kit expression at sites of kit-ligand expression affects melanogenesis. Development 118(3):705-17. [PubMed: 7521281]  [MGI Ref ID J:13166]

Lyon MF; Glenister PH. 1982. A new allele sash (Wsh) at the W-locus and a spontaneous recessive lethal in mice. Genet Res 39(3):315-22. [PubMed: 7117838]  [MGI Ref ID J:6857]

Nagle DL; Kozak CA; Mano H; Chapman VM; Bucan M. 1995. Physical mapping of the Tec and Gabrb1 loci reveals that the Wsh mutation on mouse chromosome 5 is associated with an inversion. Hum Mol Genet 4(11):2073-9. [PubMed: 8589683]  [MGI Ref ID J:29686]

Tono T; Tsujimura T; Koshimizu U; Kasugai T; Adachi S; Isozaki K; Nishikawa S; Morimoto M; Nishimune Y; Nomura S; Kitamura Y.. 1992. c-kit Gene was not transcribed in cultured mast cells of mast cell-deficient Wsh/Wsh mice that have a normal number of erythrocytes and a normal c-kit coding region. Blood 80(6):1448-53. [PubMed: 1381627]  [MGI Ref ID J:2535]

Yamazaki M; Tsujimura T; Morii E; Isozaki K; Onoue H; Nomura S; Kitamura Y. 1994. C-kit gene is expressed by skin mast cells in embryos but not in puppies of Wsh/Wsh mice: age-dependent abolishment of c-kit gene expression. Blood 83(12):3509-16. [PubMed: 7515715]  [MGI Ref ID J:18760]

Additional References

KitW-sh related

Albert EJ; Duplisea J; Dawicki W; Haidl ID; Marshall JS. 2011. Tissue eosinophilia in a mouse model of colitis is highly dependent on TLR2 and independent of mast cells. Am J Pathol 178(1):150-60. [PubMed: 21224053]  [MGI Ref ID J:168236]

Allen JD; Jaffer ZM; Park SJ; Burgin S; Hofmann C; Sells MA; Chen S; Derr-Yellin E; Michels EG; McDaniel A; Bessler WK; Ingram DA; Atkinson SJ; Travers JB; Chernoff J; Clapp DW. 2009. P21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics. Blood 113(12):2695-705. [PubMed: 19124833]  [MGI Ref ID J:145444]

Ando T; Matsumoto K; Namiranian S; Yamashita H; Glatthorn H; Kimura M; Dolan BR; Lee JJ; Galli SJ; Kawakami Y; Jamora C; Kawakami T. 2013. Mast Cells Are Required for Full Expression of Allergen/SEB-Induced Skin Inflammation. J Invest Dermatol 133(12):2695-705. [PubMed: 23752044]  [MGI Ref ID J:202870]

Ando T; Xiao W; Gao P; Namiranian S; Matsumoto K; Tomimori Y; Hong H; Yamashita H; Kimura M; Kashiwakura J; Hata TR; Izuhara K; Gurish MF; Roers A; Rafaels NM; Barnes KC; Jamora C; Kawakami Y; Kawakami T. 2014. Critical role for mast cell Stat5 activity in skin inflammation. Cell Rep 6(2):366-76. [PubMed: 24412367]  [MGI Ref ID J:208823]

Andreu P; Johansson M; Affara NI; Pucci F; Tan T; Junankar S; Korets L; Lam J; Tawfik D; Denardo DG; Naldini L; de Visser KE; De Palma M; Coussens LM. 2010. FcRgamma Activation Regulates Inflammation-Associated Squamous Carcinogenesis. Cancer Cell 17(2):121-134. [PubMed: 20138013]  [MGI Ref ID J:157152]

Aoki R; Kawamura T; Goshima F; Ogawa Y; Nakae S; Nakao A; Moriishi K; Nishiyama Y; Shimada S. 2013. Mast Cells Play a Key Role in Host Defense against Herpes Simplex Virus Infection through TNF-alpha and IL-6 Production. J Invest Dermatol 133(9):2170-9. [PubMed: 23528820]  [MGI Ref ID J:200049]

Becker M; Heib V; Klein M; Doener F; Bopp T; Taube C; Radsak M; Schild H; Schmitt E; Stassen M. 2009. Impaired mast cell-driven immune responses in mice lacking the transcription factor NFATc2. J Immunol 182(10):6136-42. [PubMed: 19414766]  [MGI Ref ID J:148241]

Becker M; Reuter S; Friedrich P; Doener F; Michel A; Bopp T; Klein M; Schmitt E; Schild H; Radsak MP; Echtenacher B; Taube C; Stassen M. 2011. Genetic variation determines mast cell functions in experimental asthma. J Immunol 186(12):7225-31. [PubMed: 21572035]  [MGI Ref ID J:175477]

Bennett JL; Blanchet MR; Zhao L; Zbytnuik L; Antignano F; Gold M; Kubes P; McNagny KM. 2009. Bone marrow-derived mast cells accumulate in the central nervous system during inflammation but are dispensable for experimental autoimmune encephalomyelitis pathogenesis. J Immunol 182(9):5507-14. [PubMed: 19380799]  [MGI Ref ID J:147712]

Bot I; de Jager SC; Bot M; van Heiningen SH; de Groot P; Veldhuizen RW; van Berkel TJ; von der Thusen JH; Biessen EA. 2010. The neuropeptide substance P mediates adventitial mast cell activation and induces intraplaque hemorrhage in advanced atherosclerosis. Circ Res 106(1):89-92. [PubMed: 19926877]  [MGI Ref ID J:170060]

Bot M; de Jager SC; MacAleese L; Lagraauw HM; van Berkel TJ; Quax PH; Kuiper J; Heeren RM; Biessen EA; Bot I. 2013. Lysophosphatidic acid triggers mast cell-driven atherosclerotic plaque destabilization by increasing vascular inflammation. J Lipid Res 54(5):1265-74. [PubMed: 23396975]  [MGI Ref ID J:196303]

Brickshawana A; Shapiro VS; Kita H; Pease LR. 2011. Lineage(-)Sca1+c-Kit(-)CD25+ cells are IL-33-responsive type 2 innate cells in the mouse bone marrow. J Immunol 187(11):5795-804. [PubMed: 22048767]  [MGI Ref ID J:179700]

Brown JM; Swindle EJ; Kushnir-Sukhov NM; Holian A; Metcalfe DD. 2007. Silica-directed mast cell activation is enhanced by scavenger receptors. Am J Respir Cell Mol Biol 36(1):43-52. [PubMed: 16902192]  [MGI Ref ID J:130522]

Byrne KT; Zhang P; Steinberg SM; Turk MJ. 2014. Autoimmune vitiligo does not require the ongoing priming of naive CD8 T cells for disease progression or associated protection against melanoma. J Immunol 192(4):1433-9. [PubMed: 24403535]  [MGI Ref ID J:209399]

Byrne SN; Limon-Flores AY; Ullrich SE. 2008. Mast Cell Migration from the Skin to the Draining Lymph Nodes upon Ultraviolet Irradiation Represents a Key Step in the Induction of Immune Suppression. J Immunol 180(7):4648-55. [PubMed: 18354188]  [MGI Ref ID J:133390]

Chacon-Salinas R; Chen L; Chavez-Blanco AD; Limon-Flores AY; Ma Y; Ullrich SE. 2014. An essential role for platelet-activating factor in activating mast cell migration following ultraviolet irradiation. J Leukoc Biol 95(1):139-48. [PubMed: 24009177]  [MGI Ref ID J:209542]

Chacon-Salinas R; Limon-Flores AY; Chavez-Blanco AD; Gonzalez-Estrada A; Ullrich SE. 2011. Mast cell-derived IL-10 suppresses germinal center formation by affecting T follicular helper cell function. J Immunol 186(1):25-31. [PubMed: 21098222]  [MGI Ref ID J:168010]

Charles N; Hardwick D; Daugas E; Illei GG; Rivera J. 2010. Basophils and the T helper 2 environment can promote the development of lupus nephritis. Nat Med 16(6):701-7. [PubMed: 20512127]  [MGI Ref ID J:161523]

Charles N; Watford WT; Ramos HL; Hellman L; Oettgen HC; Gomez G; Ryan JJ; O'Shea JJ; Rivera J. 2009. Lyn kinase controls basophil GATA-3 transcription factor expression and induction of Th2 cell differentiation. Immunity 30(4):533-43. [PubMed: 19362019]  [MGI Ref ID J:147963]

Cheng LE; Hartmann K; Roers A; Krummel MF; Locksley RM. 2013. Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin e. Immunity 38(1):166-75. [PubMed: 23290520]  [MGI Ref ID J:193023]

Cheng LE; Wang ZE; Locksley RM. 2010. Murine B cells regulate serum IgE levels in a CD23-dependent manner. J Immunol 185(9):5040-7. [PubMed: 20870945]  [MGI Ref ID J:165198]

Clemens RA; Lenox LE; Kambayashi T; Bezman N; Maltzman JS; Nichols KE; Koretzky GA. 2007. Loss of SLP-76 expression within myeloid cells confers resistance to neutrophil-mediated tissue damage while maintaining effective bacterial killing. J Immunol 178(7):4606-14. [PubMed: 17372019]  [MGI Ref ID J:145136]

Cloutier N; Pare A; Farndale RW; Schumacher HR; Nigrovic PA; Lacroix S; Boilard E. 2012. Platelets can enhance vascular permeability. Blood 120(6):1334-43. [PubMed: 22544703]  [MGI Ref ID J:188638]

Cyphert JM; Kovarova M; Allen IC; Hartney JM; Murphy DL; Wess J; Koller BH. 2009. Cooperation between mast cells and neurons is essential for antigen-mediated bronchoconstriction. J Immunol 182(12):7430-9. [PubMed: 19494266]  [MGI Ref ID J:149438]

Dawicki W; Jawdat DW; Xu N; Marshall JS. 2010. Mast cells, histamine, and IL-6 regulate the selective influx of dendritic cell subsets into an inflamed lymph node. J Immunol 184(4):2116-23. [PubMed: 20083654]  [MGI Ref ID J:159485]

Di Nardo A; Yamasaki K; Dorschner RA; Lai Y; Gallo RL. 2008. Mast cell cathelicidin antimicrobial peptide prevents invasive group a streptococcus infection of the skin. J Immunol 180(11):7565-73. [PubMed: 18490758]  [MGI Ref ID J:136326]

Doener F; Michel A; Reuter S; Friedrich P; Bohm L; Relle M; Codarri L; Tenzer S; Klein M; Bopp T; Schmitt E; Schild H; Radsak MP; Taube C; Stassen M; Becker M. 2013. Mast cell-derived mediators promote murine neutrophil effector functions. Int Immunol 25(10):553-61. [PubMed: 23728776]  [MGI Ref ID J:201921]

Drube S; Heink S; Walter S; Lohn T; Grusser M; Gerbaulet A; Berod L; Schons J; Dudeck A; Freitag J; Grotha S; Reich D; Rudeschko O; Norgauer J; Hartmann K; Roers A; Kamradt T. 2010. The receptor tyrosine kinase c-Kit controls IL-33 receptor signaling in mast cells. Blood 115(19):3899-906. [PubMed: 20200353]  [MGI Ref ID J:160247]

Dudeck A; Dudeck J; Scholten J; Petzold A; Surianarayanan S; Kohler A; Peschke K; Vohringer D; Waskow C; Krieg T; Muller W; Waisman A; Hartmann K; Gunzer M; Roers A. 2011. Mast Cells Are Key Promoters of Contact Allergy that Mediate the Adjuvant Effects of Haptens. Immunity 34(6):973-84. [PubMed: 21703544]  [MGI Ref ID J:173991]

Fang S; Wei J; Pentinmikko N; Leinonen H; Salven P. 2012. Generation of functional blood vessels from a single c-kit+ adult vascular endothelial stem cell. PLoS Biol 10(10):e1001407. [PubMed: 23091420]  [MGI Ref ID J:194015]

Fang Y; Larsson L; Mattsson J; Lycke N; Xiang Z. 2010. Mast cells contribute to the mucosal adjuvant effect of CTA1-DD after IgG-complex formation. J Immunol 185(5):2935-41. [PubMed: 20675596]  [MGI Ref ID J:163255]

Fuchs B; Sjoberg L; Moller Westerberg C; Ekoff M; Swedin L; Dahlen SE; Adner M; Nilsson GP. 2012. Mast cell engraftment of the peripheral lung enhances airway hyperresponsiveness in a mouse asthma model. Am J Physiol Lung Cell Mol Physiol 303(12):L1027-36. [PubMed: 23043076]  [MGI Ref ID J:193643]

Furumoto Y; Charles N; Olivera A; Leung WH; Dillahunt S; Sargent JL; Tinsley K; Odom S; Scott E; Wilson TM; Ghoreschi K; Kneilling M; Chen M; Lee DM; Bolland S; Rivera J. 2011. PTEN deficiency in mast cells causes a mastocytosis-like proliferative disease that heightens allergic responses and vascular permeability. Blood 118(20):5466-75. [PubMed: 21926349]  [MGI Ref ID J:178784]

Gomez-Pinilla PJ; Farro G; Di Giovangiulio M; Stakenborg N; Nemethova A; de Vries A; Liston A; Feyerabend TB; Rodewald HR; Boeckxstaens GE; Matteoli G. 2014. Mast cells play no role in the pathogenesis of postoperative ileus induced by intestinal manipulation. PLoS One 9(1):e85304. [PubMed: 24416383]  [MGI Ref ID J:212200]

Gounaris E; Erdman SE; Restaino C; Gurish MF; Friend DS; Gounari F; Lee DM; Zhang G; Glickman JN; Shin K; Rao VP; Poutahidis T; Weissleder R; McNagny KM; Khazaie K. 2007. Mast cells are an essential hematopoietic component for polyp development. Proc Natl Acad Sci U S A 104(50):19977-82. [PubMed: 18077429]  [MGI Ref ID J:128606]

Graham AC; Hilmer KM; Zickovich JM; Obar JJ. 2013. Inflammatory Response of Mast Cells during Influenza A Virus Infection Is Mediated by Active Infection and RIG-I Signaling. J Immunol 190(9):4676-84. [PubMed: 23526820]  [MGI Ref ID J:195526]

Grimbaldeston MA; Chen CC; Piliponsky AM; Tsai M; Tam SY; Galli SJ. 2005. Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo. Am J Pathol 167(3):835-48. [PubMed: 16127161]  [MGI Ref ID J:101685]

Grimbaldeston MA; Nakae S; Kalesnikoff J; Tsai M; Galli SJ. 2007. Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B. Nat Immunol 8(10):1095-104. [PubMed: 17767162]  [MGI Ref ID J:125267]

Groschwitz KR; Ahrens R; Osterfeld H; Gurish MF; Han X; Abrink M; Finkelman FD; Pejler G; Hogan SP. 2009. Mast cells regulate homeostatic intestinal epithelial migration and barrier function by a chymase/Mcpt4-dependent mechanism. Proc Natl Acad Sci U S A 106(52):22381-6. [PubMed: 20018751]  [MGI Ref ID J:156457]

Haddon DJ; Antignano F; Hughes MR; Blanchet MR; Zbytnuik L; Krystal G; McNagny KM. 2009. SHIP1 Is a repressor of mast cell hyperplasia, cytokine production, and allergic inflammation in vivo. J Immunol 183(1):228-36. [PubMed: 19542434]  [MGI Ref ID J:149977]

Hale LP; Kant EP; Greer PK; Foster WM. 2012. Iron supplementation decreases severity of allergic inflammation in murine lung. PLoS One 7(9):e45667. [PubMed: 23029172]  [MGI Ref ID J:191986]

Hampton DD; Hale LP. 2011. Mast cells are critical for protection against peptic ulcers induced by the NSAID piroxicam. PLoS One 6(8):e23669. [PubMed: 21858200]  [MGI Ref ID J:176357]

Heib V; Becker M; Warger T; Rechtsteiner G; Tertilt C; Klein M; Bopp T; Taube C; Schild H; Schmitt E; Stassen M. 2007. Mast cells are crucial for early inflammation, migration of Langerhans cells, and CTL responses following topical application of TLR7 ligand in mice. Blood 110(3):946-53. [PubMed: 17446350]  [MGI Ref ID J:145396]

Heikkila HM; Trosien J; Metso J; Jauhiainen M; Pentikainen MO; Kovanen PT; Lindstedt KA. 2010. Mast cells promote atherosclerosis by inducing both an atherogenic lipid profile and vascular inflammation. J Cell Biochem 109(3):615-23. [PubMed: 20024959]  [MGI Ref ID J:161254]

Hendrix S; Kramer P; Pehl D; Warnke K; Boato F; Nelissen S; Lemmens E; Pejler G; Metz M; Siebenhaar F; Maurer M. 2013. Mast cells protect from post-traumatic brain inflammation by the mast cell-specific chymase mouse mast cell protease-4. FASEB J 27(3):920-9. [PubMed: 23193170]  [MGI Ref ID J:196981]

Hepworth MR; Danilowicz-Luebert E; Rausch S; Metz M; Klotz C; Maurer M; Hartmann S. 2012. Mast cells orchestrate type 2 immunity to helminths through regulation of tissue-derived cytokines. Proc Natl Acad Sci U S A 109(17):6644-9. [PubMed: 22493240]  [MGI Ref ID J:183844]

Hershko AY; Charles N; Olivera A; Alvarez-Errico D; Rivera J. 2012. Cutting edge: persistence of increased mast cell numbers in tissues links dermatitis to enhanced airway disease in a mouse model of atopy. J Immunol 188(2):531-5. [PubMed: 22180615]  [MGI Ref ID J:180777]

Hershko AY; Suzuki R; Charles N; Alvarez-Errico D; Sargent JL; Laurence A; Rivera J. 2011. Mast cell interleukin-2 production contributes to suppression of chronic allergic dermatitis. Immunity 35(4):562-71. [PubMed: 21982597]  [MGI Ref ID J:177651]

Hitomi K; Tahara-Hanaoka S; Someya S; Fujiki A; Tada H; Sugiyama T; Shibayama S; Shibuya K; Shibuya A. 2010. An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E-mediated immediate hypersensitivity reactions. Nat Immunol 11(7):601-7. [PubMed: 20526344]  [MGI Ref ID J:161854]

Hu P; Carlesso N; Xu M; Liu Y; Nebreda AR; Takemoto C; Kapur R. 2012. Genetic evidence for critical roles of P38alpha protein in regulating mast cell differentiation and chemotaxis through distinct mechanisms. J Biol Chem 287(24):20258-69. [PubMed: 22518842]  [MGI Ref ID J:186514]

Hua X; Kovarova M; Chason KD; Nguyen M; Koller BH; Tilley SL. 2007. Enhanced mast cell activation in mice deficient in the A2b adenosine receptor. J Exp Med 204(1):117-28. [PubMed: 17200408]  [MGI Ref ID J:125297]

Hueber AJ; Alves-Filho JC; Asquith DL; Michels C; Millar NL; Reilly JH; Graham GJ; Liew FY; Miller AM; McInnes IB. 2011. IL-33 induces skin inflammation with mast cell and neutrophil activation. Eur J Immunol 41(8):2229-37. [PubMed: 21674479]  [MGI Ref ID J:176814]

Iino S; Horiguchi K; Nojyo Y. 2009. W(sh)/W(sh) c-Kit mutant mice possess interstitial cells of Cajal in the deep muscular plexus layer of the small intestine. Neurosci Lett 459(3):123-6. [PubMed: 19427361]  [MGI Ref ID J:150448]

Iwanaga K; Nakamura T; Maeda S; Aritake K; Hori M; Urade Y; Ozaki H; Murata T. 2014. Mast cell-derived prostaglandin D2 inhibits colitis and colitis-associated colon cancer in mice. Cancer Res 74(11):3011-9. [PubMed: 24879565]  [MGI Ref ID J:213499]

Iyer AS; August A. 2008. The Tec family kinase, IL-2-inducible T cell kinase, differentially controls mast cell responses. J Immunol 180(12):7869-77. [PubMed: 18523250]  [MGI Ref ID J:137249]

Izawa K; Yamanishi Y; Maehara A; Takahashi M; Isobe M; Ito S; Kaitani A; Matsukawa T; Matsuoka T; Nakahara F; Oki T; Kiyonari H; Abe T; Okumura K; Kitamura T; Kitaura J. 2012. The receptor LMIR3 negatively regulates mast cell activation and allergic responses by binding to extracellular ceramide. Immunity 37(5):827-39. [PubMed: 23123064]  [MGI Ref ID J:190979]

Jackson AR; Hegde VL; Nagarkatti PS; Nagarkatti M. 2014. Characterization of endocannabinoid-mediated induction of myeloid-derived suppressor cells involving mast cells and MCP-1. J Leukoc Biol 95(4):609-19. [PubMed: 24319288]  [MGI Ref ID J:211870]

Jessup HK; Brewer AW; Omori M; Rickel EA; Budelsky AL; Yoon BR; Ziegler SF; Comeau MR. 2008. Intradermal administration of thymic stromal lymphopoietin induces a T cell- and eosinophil-dependent systemic Th2 inflammatory response. J Immunol 181(6):4311-9. [PubMed: 18768889]  [MGI Ref ID J:139079]

Jin C; Shelburne CP; Li G; Potts EN; Riebe KJ; Sempowski GD; Foster WM; Abraham SN. 2011. Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation. J Clin Invest 121(3):941-55. [PubMed: 21285515]  [MGI Ref ID J:171819]

Jones TG; Hallgren J; Humbles A; Burwell T; Finkelman FD; Alcaide P; Austen KF; Gurish MF. 2009. Antigen-induced increases in pulmonary mast cell progenitor numbers depend on IL-9 and CD1d-restricted NKT cells. J Immunol 183(8):5251-60. [PubMed: 19783672]  [MGI Ref ID J:153832]

Jonsson F; Mancardi DA; Zhao W; Kita Y; Iannascoli B; Khun H; van Rooijen N; Shimizu T; Schwartz LB; Daeron M; Bruhns P. 2012. Human FcgammaRIIA induces anaphylactic and allergic reactions. Blood 119(11):2533-44. [PubMed: 22138510]  [MGI Ref ID J:182466]

Junkins RD; Carrigan SO; Wu Z; Stadnyk AW; Cowley E; Issekutz T; Berman J; Lin TJ. 2014. Mast cells protect against Pseudomonas aeruginosa-induced lung injury. Am J Pathol 184(8):2310-21. [PubMed: 25043620]  [MGI Ref ID J:213946]

Kakurai M; Monteforte R; Suto H; Tsai M; Nakae S; Galli SJ. 2006. Mast cell-derived tumor necrosis factor can promote nerve fiber elongation in the skin during contact hypersensitivity in mice. Am J Pathol 169(5):1713-21. [PubMed: 17071594]  [MGI Ref ID J:114981]

Karlberg M; Ekoff M; Huang DC; Mustonen P; Harvima IT; Nilsson G. 2010. The BH3-Mimetic ABT-737 Induces Mast Cell Apoptosis In Vitro and In Vivo: Potential for Therapeutics. J Immunol 185(4):2555-62. [PubMed: 20639495]  [MGI Ref ID J:162536]

Kim K; Petrova YM; Scott BL; Nigam R; Agrawal A; Evans CM; Azzegagh Z; Gomez A; Rodarte EM; Olkkonen VM; Bagirzadeh R; Piccotti L; Ren B; Yoon JH; McNew JA; Adachi R; Tuvim MJ; Dickey BF. 2012. Munc18b is an essential gene in mice whose expression is limiting for secretion by airway epithelial and mast cells. Biochem J 446(3):383-94. [PubMed: 22694344]  [MGI Ref ID J:188931]

Kitamura Y; Yamazaki M; Nomura S; Tsujimura T. 1993. Cell type specific and age specific suppression of c-kit gene expression in mutant mice of Wsh/Wsh genotype Exp Hematol 21(8):1175 (Abstr.).  [MGI Ref ID J:13326]

Kojima T; Obata K; Mukai K; Sato S; Takai T; Minegishi Y; Karasuyama H. 2007. Mast cells and basophils are selectively activated in vitro and in vivo through CD200R3 in an IgE-independent manner. J Immunol 179(10):7093-100. [PubMed: 17982101]  [MGI Ref ID J:153851]

Komai-Koma M; Gilchrist DS; McKenzie AN; Goodyear CS; Xu D; Liew FY. 2011. IL-33 activates B1 cells and exacerbates contact sensitivity. J Immunol 186(4):2584-91. [PubMed: 21239718]  [MGI Ref ID J:169159]

Kurashima Y; Amiya T; Nochi T; Fujisawa K; Haraguchi T; Iba H; Tsutsui H; Sato S; Nakajima S; Iijima H; Kubo M; Kunisawa J; Kiyono H. 2012. Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors. Nat Commun 3:1034. [PubMed: 22948816]  [MGI Ref ID J:195470]

Kuroda E; Antignano F; Ho VW; Hughes MR; Ruschmann J; Lam V; Kawakami T; Kerr WG; McNagny KM; Sly LM; Krystal G. 2011. SHIP represses Th2 skewing by inhibiting IL-4 production from basophils. J Immunol 186(1):323-32. [PubMed: 21131429]  [MGI Ref ID J:168693]

Lai JF; Zindl CL; Duffy LB; Atkinson TP; Jung YW; van Rooijen N; Waites KB; Krause DC; Chaplin DD. 2010. Critical role of macrophages and their activation via MyD88-NFkappaB signaling in lung innate immunity to Mycoplasma pneumoniae. PLoS One 5(12):e14417. [PubMed: 21203444]  [MGI Ref ID J:168336]

Lee-Rueckert M; Silvennoinen R; Rotllan N; Judstrom I; Blanco-Vaca F; Metso J; Jauhiainen M; Kovanen PT; Escola-Gil JC. 2011. Mast cell activation in vivo impairs the macrophage reverse cholesterol transport pathway in the mouse. Arterioscler Thromb Vasc Biol 31(3):520-7. [PubMed: 21212401]  [MGI Ref ID J:184173]

Leveson-Gower DB; Sega EI; Kalesnikoff J; Florek M; Pan Y; Pierini A; Galli SJ; Negrin RS. 2013. Mast cells suppress murine GVHD in a mechanism independent of CD4+CD25+ regulatory T cells. Blood 122(22):3659-65. [PubMed: 24030387]  [MGI Ref ID J:204074]

Li H; Nourbakhsh B; Safavi F; Li K; Xu H; Cullimore M; Zhou F; Zhang G; Rostami A. 2011. Kit (W-sh) mice develop earlier and more severe experimental autoimmune encephalomyelitis due to absence of immune suppression. J Immunol 187(1):274-82. [PubMed: 21646293]  [MGI Ref ID J:176181]

Lilla JN; Joshi RV; Craik CS; Werb Z. 2009. Active plasma kallikrein localizes to mast cells and regulates epithelial cell apoptosis, adipocyte differentiation, and stromal remodeling during mammary gland involution. J Biol Chem 284(20):13792-803. [PubMed: 19297327]  [MGI Ref ID J:149739]

Lilla JN; Werb Z. 2010. Mast cells contribute to the stromal microenvironment in mammary gland branching morphogenesis. Dev Biol 337(1):124-33. [PubMed: 19850030]  [MGI Ref ID J:157030]

Liu J; Divoux A; Sun J; Zhang J; Clement K; Glickman JN; Sukhova GK; Wolters PJ; Du J; Gorgun CZ; Doria A; Libby P; Blumberg RS; Kahn BB; Hotamisligil GS; Shi GP. 2009. Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat Med 15(8):940-5. [PubMed: 19633655]  [MGI Ref ID J:152187]

Liu Q; Tang Z; Surdenikova L; Kim S; Patel KN; Kim A; Ru F; Guan Y; Weng HJ; Geng Y; Undem BJ; Kollarik M; Chen ZF; Anderson DJ; Dong X. 2009. Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus. Cell 139(7):1353-65. [PubMed: 20004959]  [MGI Ref ID J:157470]

Liu T; Xu ZZ; Park CK; Berta T; Ji RR. 2010. Toll-like receptor 7 mediates pruritus. Nat Neurosci 13(12):1460-2. [PubMed: 21037581]  [MGI Ref ID J:166905]

Liu ZQ; Song JP; Liu X; Jiang J; Chen X; Yang L; Hu T; Zheng PY; Liu ZG; Yang PC. 2014. Mast cell-derived serine proteinase regulates T helper 2 polarization. Sci Rep 4:4649. [PubMed: 24721951]  [MGI Ref ID J:210516]

Lu LF; Lind EF; Gondek DC; Bennett KA; Gleeson MW; Pino-Lagos K; Scott ZA; Coyle AJ; Reed JL; Van Snick J; Strom TB; Zheng XX; Noelle RJ. 2006. Mast cells are essential intermediaries in regulatory T-cell tolerance. Nature 442(7106):997-1002. [PubMed: 16921386]  [MGI Ref ID J:112226]

Ma P; Mali RS; Munugalavadla V; Krishnan S; Ramdas B; Sims E; Martin H; Ghosh J; Li S; Chan RJ; Krystal G; Craig AW; Takemoto C; Kapur R. 2011. The PI3K pathway drives the maturation of mast cells via microphthalmia transcription factor. Blood 118(13):3459-69. [PubMed: 21791431]  [MGI Ref ID J:177075]

MacNeil AJ; Yang YJ; Lin TJ. 2011. MAPK kinase 3 specifically regulates Fc epsilonRI-mediated IL-4 production by mast cells. J Immunol 187(6):3374-82. [PubMed: 21841136]  [MGI Ref ID J:179249]

Mali RS; Ma P; Zeng LF; Martin H; Ramdas B; He Y; Sims E; Nabinger S; Ghosh J; Sharma N; Munugalavadla V; Chatterjee A; Li S; Sandusky G; Craig AW; Bunting KD; Feng GS; Chan RJ; Zhang ZY; Kapur R. 2012. Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT. Blood 120(13):2669-78. [PubMed: 22806893]  [MGI Ref ID J:189153]

Mallen-St Clair J; Pham CT; Villalta SA; Caughey GH; Wolters PJ. 2004. Mast cell dipeptidyl peptidase I mediates survival from sepsis. J Clin Invest 113(4):628-34. [PubMed: 14966572]  [MGI Ref ID J:88160]

Marichal T; Starkl P; Reber LL; Kalesnikoff J; Oettgen HC; Tsai M; Metz M; Galli SJ. 2013. A beneficial role for immunoglobulin E in host defense against honeybee venom. Immunity 39(5):963-75. [PubMed: 24210352]  [MGI Ref ID J:208997]

Melicoff E; Sansores-Garcia L; Gomez A; Moreira DC; Datta P; Thakur P; Petrova Y; Siddiqi T; Murthy JN; Dickey BF; Heidelberger R; Adachi R. 2009. Synaptotagmin-2 controls regulated exocytosis but not other secretory responses of mast cells. J Biol Chem 284(29):19445-51. [PubMed: 19473977]  [MGI Ref ID J:152273]

Metz M; Piliponsky AM; Chen CC; Lammel V; Abrink M; Pejler G; Tsai M; Galli SJ. 2006. Mast cells can enhance resistance to snake and honeybee venoms. Science 313(5786):526-30. [PubMed: 16873664]  [MGI Ref ID J:110940]

Michel A; Schuler A; Friedrich P; Doner F; Bopp T; Radsak M; Hoffmann M; Relle M; Distler U; Kuharev J; Tenzer S; Feyerabend TB; Rodewald HR; Schild H; Schmitt E; Becker M; Stassen M. 2013. Mast cell-deficient Kit(W-sh) "Sash" mutant mice display aberrant myelopoiesis leading to the accumulation of splenocytes that act as myeloid-derived suppressor cells. J Immunol 190(11):5534-44. [PubMed: 23636054]  [MGI Ref ID J:204768]

Miyata M; Hatsushika K; Ando T; Shimokawa N; Ohnuma Y; Katoh R; Suto H; Ogawa H; Masuyama K; Nakao A. 2008. Mast cell regulation of epithelial TSLP expression plays an important role in the development of allergic rhinitis. Eur J Immunol 38(6):1487-92. [PubMed: 18461563]  [MGI Ref ID J:136211]

Morimoto K; Shirata N; Taketomi Y; Tsuchiya S; Segi-Nishida E; Inazumi T; Kabashima K; Tanaka S; Murakami M; Narumiya S; Sugimoto Y. 2014. Prostaglandin E2-EP3 signaling induces inflammatory swelling by mast cell activation. J Immunol 192(3):1130-7. [PubMed: 24342806]  [MGI Ref ID J:207320]

Murata T; Aritake K; Matsumoto S; Kamauchi S; Nakagawa T; Hori M; Momotani E; Urade Y; Ozaki H. 2011. Prostagladin D2 is a mast cell-derived antiangiogenic factor in lung carcinoma. Proc Natl Acad Sci U S A 108(49):19802-7. [PubMed: 22106279]  [MGI Ref ID J:180450]

Nakae S; Suto H; Berry GJ; Galli SJ. 2007. Mast cell-derived TNF can promote Th17 cell-dependent neutrophil recruitment in ovalbumin-challenged OTII mice. Blood 109(9):3640-8. [PubMed: 17197430]  [MGI Ref ID J:145332]

Nakae S; Suto H; Kakurai M; Sedgwick JD; Tsai M; Galli SJ. 2005. Mast cells enhance T cell activation: Importance of mast cell-derived TNF. Proc Natl Acad Sci U S A 102(18):6467-72. [PubMed: 15840716]  [MGI Ref ID J:98468]

Nakahashi-Oda C; Tahara-Hanaoka S; Shoji M; Okoshi Y; Nakano-Yokomizo T; Ohkohchi N; Yasui T; Kikutani H; Honda S; Shibuya K; Nagata S; Shibuya A. 2012. Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor. J Exp Med 209(8):1493-503. [PubMed: 22826299]  [MGI Ref ID J:189144]

Nakamura Y; Franchi L; Kambe N; Meng G; Strober W; Nunez G. 2012. Critical role for mast cells in interleukin-1beta-driven skin inflammation associated with an activating mutation in the nlrp3 protein. Immunity 37(1):85-95. [PubMed: 22819042]  [MGI Ref ID J:187396]

Nakamura Y; Oscherwitz J; Cease KB; Chan SM; Munoz-Planillo R; Hasegawa M; Villaruz AE; Cheung GY; McGavin MJ; Travers JB; Otto M; Inohara N; Nunez G. 2013. Staphylococcus delta-toxin induces allergic skin disease by activating mast cells. Nature 503(7476):397-401. [PubMed: 24172897]  [MGI Ref ID J:207709]

Nauta AC; Grova M; Montoro DT; Zimmermann A; Tsai M; Gurtner GC; Galli SJ; Longaker MT. 2013. Evidence that mast cells are not required for healing of splinted cutaneous excisional wounds in mice. PLoS One 8(3):e59167. [PubMed: 23544053]  [MGI Ref ID J:199526]

Nautiyal KM; Dailey CA; Jahn JL; Rodriquez E; Son NH; Sweedler JV; Silver R. 2012. Serotonin of mast cell origin contributes to hippocampal function. Eur J Neurosci 36(3):2347-59. [PubMed: 22632453]  [MGI Ref ID J:207665]

Nautiyal KM; McKellar H; Silverman AJ; Silver R. 2009. Mast cells are necessary for the hypothermic response to LPS-induced sepsis. Am J Physiol Regul Integr Comp Physiol 296(3):R595-602. [PubMed: 19109365]  [MGI Ref ID J:148624]

Nautiyal KM; Ribeiro AC; Pfaff DW; Silver R. 2008. Brain mast cells link the immune system to anxiety-like behavior. Proc Natl Acad Sci U S A 105(46):18053-7. [PubMed: 19004805]  [MGI Ref ID J:142511]

Neill DR; Wong SH; Bellosi A; Flynn RJ; Daly M; Langford TK; Bucks C; Kane CM; Fallon PG; Pannell R; Jolin HE; McKenzie AN. 2010. Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature 464(7293):1367-70. [PubMed: 20200518]  [MGI Ref ID J:159464]

Nelissen S; Vangansewinkel T; Geurts N; Geboes L; Lemmens E; Vidal PM; Lemmens S; Willems L; Boato F; Dooley D; Pehl D; Pejler G; Maurer M; Metz M; Hendrix S. 2013. Mast cells protect from post-traumatic spinal cord damage in mice by degrading inflammation-associated cytokines via mouse mast cell protease 4. Neurobiol Dis :. [PubMed: 24075853]  [MGI Ref ID J:201810]

Nigrovic PA; Gray DH; Jones T; Hallgren J; Kuo FC; Chaletzky B; Gurish M; Mathis D; Benoist C; Lee DM. 2008. Genetic inversion in mast cell-deficient (W(sh)) mice interrupts corin and manifests as hematopoietic and cardiac aberrancy. Am J Pathol 173(6):1693-701. [PubMed: 18988802]  [MGI Ref ID J:141413]

Nishida K; Hasegawa A; Nakae S; Oboki K; Saito H; Yamasaki S; Hirano T. 2009. Zinc transporter Znt5/Slc30a5 is required for the mast cell-mediated delayed-type allergic reaction but not the immediate-type reaction. J Exp Med 206(6):1351-64. [PubMed: 19451265]  [MGI Ref ID J:149448]

Nocka K; Tan JC; Chiu E; Chu TY; Ray P; Traktman P; Besmer P. 1990. Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W. EMBO J 9(6):1805-13. [PubMed: 1693331]  [MGI Ref ID J:10528]

Nowak EC; de Vries VC; Wasiuk A; Ahonen C; Bennett KA; Le Mercier I; Ha DG; Noelle RJ. 2012. Tryptophan hydroxylase-1 regulates immune tolerance and inflammation. J Exp Med 209(11):2127-35. [PubMed: 23008335]  [MGI Ref ID J:190958]

Ogawa K; Tanaka Y; Uruno T; Duan X; Harada Y; Sanematsu F; Yamamura K; Terasawa M; Nishikimi A; Cote JF; Fukui Y. 2014. DOCK5 functions as a key signaling adaptor that links FcepsilonRI signals to microtubule dynamics during mast cell degranulation. J Exp Med 211(7):1407-19. [PubMed: 24913231]  [MGI Ref ID J:214448]

Oh MH; Oh SY; Lu J; Lou H; Myers AC; Zhu Z; Zheng T. 2013. TRPA1-dependent pruritus in IL-13-induced chronic atopic dermatitis. J Immunol 191(11):5371-82. [PubMed: 24140646]  [MGI Ref ID J:207026]

Ohneda K; Moriguchi T; Ohmori S; Ishijima Y; Satoh H; Philipsen S; Yamamoto M. 2014. Transcription factor GATA1 is dispensable for mast cell differentiation in adult mice. Mol Cell Biol 34(10):1812-26. [PubMed: 24615013]  [MGI Ref ID J:213664]

Ohnmacht C; Schwartz C; Panzer M; Schiedewitz I; Naumann R; Voehringer D. 2010. Basophils orchestrate chronic allergic dermatitis and protective immunity against helminths. Immunity 33(3):364-74. [PubMed: 20817571]  [MGI Ref ID J:164432]

Ohnmacht C; Voehringer D. 2010. Basophils protect against reinfection with hookworms independently of mast cells and memory Th2 cells. J Immunol 184(1):344-50. [PubMed: 19955520]  [MGI Ref ID J:158997]

Oka T; Kalesnikoff J; Starkl P; Tsai M; Galli SJ. 2012. Evidence questioning cromolyn's effectiveness and selectivity as a 'mast cell stabilizer' in mice. Lab Invest 92(10):1472-82. [PubMed: 22906983]  [MGI Ref ID J:189899]

Oldford SA; Haidl ID; Howatt MA; Leiva CA; Johnston B; Marshall JS. 2010. A Critical Role for Mast Cells and Mast Cell-Derived IL-6 in TLR2-Mediated Inhibition of Tumor Growth. J Immunol 185(11):7067-76. [PubMed: 21041732]  [MGI Ref ID J:166133]

Olivera A; Eisner C; Kitamura Y; Dillahunt S; Allende L; Tuymetova G; Watford W; Meylan F; Diesner SC; Li L; Schnermann J; Proia RL; Rivera J. 2010. Sphingosine kinase 1 and sphingosine-1-phosphate receptor 2 are vital to recovery from anaphylactic shock in mice. J Clin Invest 120(5):1429-40. [PubMed: 20407207]  [MGI Ref ID J:161468]

Olivera A; Kitamura Y; Wright LD; Allende ML; Chen W; Kaneko-Goto T; Yoshihara Y; Proia RL; Rivera J. 2013. Sphingosine-1-phosphate can promote mast cell hyper-reactivity through regulation of contactin-4 expression. J Leukoc Biol 94(5):1013-24. [PubMed: 23904439]  [MGI Ref ID J:209552]

Olivera A; Mizugishi K; Tikhonova A; Ciaccia L; Odom S; Proia RL; Rivera J. 2007. The sphingosine kinase-sphingosine-1-phosphate axis is a determinant of mast cell function and anaphylaxis. Immunity 26(3):287-97. [PubMed: 17346996]  [MGI Ref ID J:120074]

Ortonne N; Ram-Wolff C; Giustiniani J; Marie-Cardine A; Bagot M; Mecheri S; Bensussan A. 2011. Human and mouse mast cells express and secrete the GPI-anchored isoform of CD160. J Invest Dermatol 131(4):916-24. [PubMed: 21191401]  [MGI Ref ID J:182084]

Palm NW; Medzhitov R. 2013. Role of the inflammasome in defense against venoms. Proc Natl Acad Sci U S A 110(5):1809-14. [PubMed: 23297192]  [MGI Ref ID J:193717]

Piliponsky AM; Chen CC; Grimbaldeston MA; Burns-Guydish SM; Hardy J; Kalesnikoff J; Contag CH; Tsai M; Galli SJ. 2010. Mast cell-derived TNF can exacerbate mortality during severe bacterial infections in C57BL/6-KitW-sh/W-sh mice. Am J Pathol 176(2):926-38. [PubMed: 20035049]  [MGI Ref ID J:156439]

Piliponsky AM; Chen CC; Rios EJ; Treuting PM; Lahiri A; Abrink M; Pejler G; Tsai M; Galli SJ. 2012. The chymase mouse mast cell protease 4 degrades TNF, limits inflammation, and promotes survival in a model of sepsis. Am J Pathol 181(3):875-86. [PubMed: 22901752]  [MGI Ref ID J:189929]

Pittoni P; Tripodo C; Piconese S; Mauri G; Parenza M; Rigoni A; Sangaletti S; Colombo MP. 2011. Mast cell targeting hampers prostate adenocarcinoma development but promotes the occurrence of highly malignant neuroendocrine cancers. Cancer Res 71(18):5987-97. [PubMed: 21896641]  [MGI Ref ID J:176436]

Potenzieri C; Meeker S; Undem BJ. 2012. Activation of mouse bronchopulmonary C-fibres by serotonin and allergen-ovalbumin challenge. J Physiol 590(Pt 21):5449-59. [PubMed: 22907059]  [MGI Ref ID J:202079]

Pozniak CD; Sengupta Ghosh A; Gogineni A; Hanson JE; Lee SH; Larson JL; Solanoy H; Bustos D; Li H; Ngu H; Jubb AM; Ayalon G; Wu J; Scearce-Levie K; Zhou Q; Weimer RM; Kirkpatrick DS; Lewcock JW. 2013. Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration. J Exp Med 210(12):2553-67. [PubMed: 24166713]  [MGI Ref ID J:207720]

Price AE; Liang HE; Sullivan BM; Reinhardt RL; Eisley CJ; Erle DJ; Locksley RM. 2010. Systemically dispersed innate IL-13-expressing cells in type 2 immunity. Proc Natl Acad Sci U S A 107(25):11489-94. [PubMed: 20534524]  [MGI Ref ID J:161387]

Pushparaj PN; Tay HK; H'ng SC; Pitman N; Xu D; McKenzie A; Liew FY; Melendez AJ. 2009. The cytokine interleukin-33 mediates anaphylactic shock. Proc Natl Acad Sci U S A 106(24):9773-8. [PubMed: 19506243]  [MGI Ref ID J:150049]

Qi X; Hong J; Chaves L; Zhuang Y; Chen Y; Wang D; Chabon J; Graham B; Ohmori K; Li Y; Huang H. 2013. Antagonistic regulation by the transcription factors C/EBPalpha and MITF specifies basophil and mast cell fates. Immunity 39(1):97-110. [PubMed: 23871207]  [MGI Ref ID J:208242]

Rabenhorst A; Schlaak M; Heukamp LC; Forster A; Theurich S; von Bergwelt-Baildon M; Buttner R; Kurschat P; Mauch C; Roers A; Hartmann K. 2012. Mast cells play a protumorigenic role in primary cutaneous lymphoma. Blood 120(10):2042-54. [PubMed: 22837530]  [MGI Ref ID J:191326]

Reber LL; Marichal T; Mukai K; Kita Y; Tokuoka SM; Roers A; Hartmann K; Karasuyama H; Nadeau KC; Tsai M; Galli SJ. 2013. Selective ablation of mast cells or basophils reduces peanut-induced anaphylaxis in mice. J Allergy Clin Immunol 132(4):881-8.e1-11. [PubMed: 23915716]  [MGI Ref ID J:205536]

Reese TA; Liang HE; Tager AM; Luster AD; Van Rooijen N; Voehringer D; Locksley RM. 2007. Chitin induces accumulation in tissue of innate immune cells associated with allergy. Nature 447(7140):92-6. [PubMed: 17450126]  [MGI Ref ID J:122735]

Rork TH; Wallace KL; Kennedy DP; Marshall MA; Lankford AR; Linden J. 2008. Adenosine A2A receptor activation reduces infarct size in the isolated, perfused mouse heart by inhibiting resident cardiac mast cell degranulation. Am J Physiol Heart Circ Physiol 295(5):H1825-33. [PubMed: 18757481]  [MGI Ref ID J:142451]

Roy A; Ganesh G; Sippola H; Bolin S; Sawesi O; Dagalv A; Schlenner SM; Feyerabend T; Rodewald HR; Kjellen L; Hellman L; Abrink M. 2014. Mast cell chymase degrades the alarmins heat shock protein 70, biglycan, HMGB1, and interleukin-33 (IL-33) and limits danger-induced inflammation. J Biol Chem 289(1):237-50. [PubMed: 24257755]  [MGI Ref ID J:207182]

Rudick CN; Bryce PJ; Guichelaar LA; Berry RE; Klumpp DJ. 2008. Mast cell-derived histamine mediates cystitis pain. PLoS ONE 3(5):e2096. [PubMed: 18461160]  [MGI Ref ID J:136218]

Saenz SA; Siracusa MC; Perrigoue JG; Spencer SP; Urban JF Jr; Tocker JE; Budelsky AL; Kleinschek MA; Kastelein RA; Kambayashi T; Bhandoola A; Artis D. 2010. IL25 elicits a multipotent progenitor cell population that promotes T(H)2 cytokine responses. Nature 464(7293):1362-6. [PubMed: 20200520]  [MGI Ref ID J:159463]

Sakata-Yanagimoto M; Sakai T; Miyake Y; Saito TI; Maruyama H; Morishita Y; Nakagami-Yamaguchi E; Kumano K; Yagita H; Fukayama M; Ogawa S; Kurokawa M; Yasutomo K; Chiba S. 2011. Notch2 signaling is required for proper mast cell distribution and mucosal immunity in the intestine. Blood 117(1):128-34. [PubMed: 20971948]  [MGI Ref ID J:168409]

Saleem SJ; Martin RK; Morales JK; Sturgill JL; Gibb DR; Graham L; Bear HD; Manjili MH; Ryan JJ; Conrad DH. 2012. Cutting edge: mast cells critically augment myeloid-derived suppressor cell activity. J Immunol 189(2):511-5. [PubMed: 22706087]  [MGI Ref ID J:189539]

Sandig H; Jobbings CE; Roldan NG; Whittingham-Dowd JK; Orinska Z; Takeuchi O; Akira S; Bulfone-Paus S. 2013. IL-33 causes selective mast cell tolerance to bacterial cell wall products by inducing IRAK1 degradation. Eur J Immunol 43(4):979-88. [PubMed: 23404570]  [MGI Ref ID J:195046]

Seeley EJ; Barry SS; Narala S; Matthay MA; Wolters PJ. 2013. Noradrenergic Neurons Regulate Monocyte Trafficking and Mortality during Gram-Negative Peritonitis in Mice. J Immunol 190(9):4717-24. [PubMed: 23543756]  [MGI Ref ID J:195507]

Serra-Pages M; Olivera A; Torres R; Picado C; de Mora F; Rivera J. 2012. E-prostanoid 2 receptors dampen mast cell degranulation via cAMP/PKA-mediated suppression of IgE-dependent signaling. J Leukoc Biol 92(6):1155-65. [PubMed: 22859831]  [MGI Ref ID J:191113]

Sharma N; Kumar V; Everingham S; Mali RS; Kapur R; Zeng LF; Zhang ZY; Feng GS; Hartmann K; Roers A; Craig AW. 2012. SH2 domain-containing phosphatase 2 is a critical regulator of connective tissue mast cell survival and homeostasis in mice. Mol Cell Biol 32(14):2653-63. [PubMed: 22566685]  [MGI Ref ID J:186664]

Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York.  [MGI Ref ID J:78801]

Sinnamon MJ; Carter KJ; Sims LP; Lafleur B; Fingleton B; Matrisian LM. 2008. A protective role of mast cells in intestinal tumorigenesis. Carcinogenesis 29(4):880-6. [PubMed: 18258601]  [MGI Ref ID J:133499]

Smith DD; Tan X; Raveendran VV; Tawfik O; Stechschulte DJ; Dileepan KN. 2012. Mast cell deficiency attenuates progression of atherosclerosis and hepatic steatosis in apolipoprotein E-null mice. Am J Physiol Heart Circ Physiol 302(12):H2612-21. [PubMed: 22505639]  [MGI Ref ID J:188087]

Soucek L; Lawlor ER; Soto D; Shchors K; Swigart LB; Evan GI. 2007. Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors. Nat Med 13(10):1211-8. [PubMed: 17906636]  [MGI Ref ID J:130030]

St John AL; Rathore AP; Yap H; Ng ML; Metcalfe DD; Vasudevan SG; Abraham SN. 2011. Immune surveillance by mast cells during dengue infection promotes natural killer (NK) and NKT-cell recruitment and viral clearance. Proc Natl Acad Sci U S A 108(22):9190-5. [PubMed: 21576486]  [MGI Ref ID J:173363]

Stephenson DA; Glenister PH; Hornby JE. 1985. Site of beige (bg) and leaden (ln) pigment gene expression determined by recombinant embryonic skin grafts and aggregation mouse chimaeras employing sash (Wsh) homozygotes. Genet Res 46(2):193-205. [PubMed: 3910518]  [MGI Ref ID J:8167]

Sun J; Sukhova GK; Wolters PJ; Yang M; Kitamoto S; Libby P; MacFarlane LA; Mallen-St Clair J; Shi GP. 2007. Mast cells promote atherosclerosis by releasing proinflammatory cytokines. Nat Med 13(6):719-24. [PubMed: 17546038]  [MGI Ref ID J:125116]

Sun J; Sukhova GK; Yang M; Wolters PJ; MacFarlane LA; Libby P; Sun C; Zhang Y; Liu J; Ennis TL; Knispel R; Xiong W; Thompson RW; Baxter BT; Shi GP. 2007. Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice. J Clin Invest 117(11):3359-68. [PubMed: 17932568]  [MGI Ref ID J:127400]

Sun J; Zhang J; Lindholt JS; Sukhova GK; Liu J; He A; Abrink M; Pejler G; Stevens RL; Thompson RW; Ennis TL; Gurish MF; Libby P; Shi GP. 2009. Critical role of mast cell chymase in mouse abdominal aortic aneurysm formation. Circulation 120(11):973-82. [PubMed: 19720934]  [MGI Ref ID J:167502]

Sutherland RE; Olsen JS; McKinstry A; Villalta SA; Wolters PJ. 2008. Mast cell IL-6 improves survival from Klebsiella pneumonia and sepsis by enhancing neutrophil killing. J Immunol 181(8):5598-605. [PubMed: 18832718]  [MGI Ref ID J:140758]

Suto H; Nakae S; Kakurai M; Sedgwick JD; Tsai M; Galli SJ. 2006. Mast cell-associated TNF promotes dendritic cell migration. J Immunol 176(7):4102-12. [PubMed: 16547246]  [MGI Ref ID J:129877]

Suzukawa M; Morita H; Nambu A; Arae K; Shimura E; Shibui A; Yamaguchi S; Suzukawa K; Nakanishi W; Oboki K; Kajiwara N; Ohno T; Ishii A; Korner H; Cua DJ; Suto H; Yoshimoto T; Iwakura Y; Yamasoba T; Ohta K; Sudo K; Saito H; Okumura K; Broide DH; MatsumotoK; Nakae S. 2012. Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, is crucial for murine asthma. J Immunol 189(7):3641-52. [PubMed: 22942422]  [MGI Ref ID J:190342]

Taketomi Y; Ueno N; Kojima T; Sato H; Murase R; Yamamoto K; Tanaka S; Sakanaka M; Nakamura M; Nishito Y; Kawana M; Kambe N; Ikeda K; Taguchi R; Nakamizo S; Kabashima K; Gelb MH; Arita M; Yokomizo T; Nakamura M; Watanabe K; Hirai H; Nakamura M; Okayama Y;Ra C; Aritake K; Urade Y; Morimoto K; Sugimoto Y; Shimizu T; Narumiya S; Hara S; Murakami M. 2013. Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis. Nat Immunol 14(6):554-63. [PubMed: 23624557]  [MGI Ref ID J:197334]

Tanaka A; Nomura Y; Matsuda A; Ohmori K; Matsuda H. 2011. Mast cells function as an alternative modulator of adipogenesis through 15-deoxy-delta-12, 14-prostaglandin J2. Am J Physiol Cell Physiol 301(6):C1360-7. [PubMed: 21865589]  [MGI Ref ID J:178344]

Thompson AL; Johnson BT; Sempowski GD; Gunn MD; Hou B; Defranco AL; Staats HF. 2012. Maximal Adjuvant Activity of Nasally Delivered IL-1alpha Requires Adjuvant-Responsive CD11c+ Cells and Does Not Correlate with Adjuvant-Induced In Vivo Cytokine Production. J Immunol 188(6):2834-46. [PubMed: 22345651]  [MGI Ref ID J:181839]

Tsujimura Y; Obata K; Mukai K; Shindou H; Yoshida M; Nishikado H; Kawano Y; Minegishi Y; Shimizu T; Karasuyama H. 2008. Basophils play a pivotal role in immunoglobulin-G-mediated but not immunoglobulin-E-mediated systemic anaphylaxis. Immunity 28(4):581-9. [PubMed: 18342553]  [MGI Ref ID J:134463]

Vosskuhl K; Greten TF; Manns MP; Korangy F; Wedemeyer J. 2010. Lipopolysaccharide-mediated mast cell activation induces IFN-gamma secretion by NK cells. J Immunol 185(1):119-25. [PubMed: 20511546]  [MGI Ref ID J:161439]

Wada T; Ishiwata K; Koseki H; Ishikura T; Ugajin T; Ohnuma N; Obata K; Ishikawa R; Yoshikawa S; Mukai K; Kawano Y; Minegishi Y; Yokozeki H; Watanabe N; Karasuyama H. 2010. Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks. J Clin Invest 120(8):2867-75. [PubMed: 20664169]  [MGI Ref ID J:163761]

Wang Z; Lai Y; Bernard JJ; Macleod DT; Cogen AL; Moss B; Di Nardo A. 2012. Skin mast cells protect mice against vaccinia virus by triggering mast cell receptor S1PR2 and releasing antimicrobial peptides. J Immunol 188(1):345-57. [PubMed: 22140255]  [MGI Ref ID J:180895]

Wang Z; MacLeod DT; Di Nardo A. 2012. Commensal bacteria lipoteichoic acid increases skin mast cell antimicrobial activity against vaccinia viruses. J Immunol 189(4):1551-8. [PubMed: 22772452]  [MGI Ref ID J:189762]

Weigand LA; Myers AC; Meeker S; Undem BJ. 2009. Mast cell-cholinergic nerve interaction in mouse airways. J Physiol 587(Pt 13):3355-62. [PubMed: 19403609]  [MGI Ref ID J:176797]

Wolters PJ; Mallen-St Clair J; Lewis CC; Villalta SA; Baluk P; Erle DJ; Caughey GH. 2005. Tissue-selective mast cell reconstitution and differential lung gene expression in mast cell-deficient Kit(W-sh)/Kit(W-sh) sash mice. Clin Exp Allergy 35(1):82-8. [PubMed: 15649271]  [MGI Ref ID J:109813]

Wu Z; Macneil AJ; Junkins R; Li B; Berman JN; Lin TJ. 2013. Mast Cell Fc{varepsilon}RI-Induced Early Growth Response 2 Regulates CC Chemokine Ligand 1-Dependent CD4+ T Cell Migration. J Immunol 190(9):4500-7. [PubMed: 23536637]  [MGI Ref ID J:195512]

Xu D; Jiang HR; Li Y; Pushparaj PN; Kurowska-Stolarska M; Leung BP; Mu R; Tay HK; McKenzie AN; McInnes IB; Melendez AJ; Liew FY. 2010. IL-33 exacerbates autoantibody-induced arthritis. J Immunol 184(5):2620-6. [PubMed: 20139274]  [MGI Ref ID J:159640]

Xu X; Zhang D; Zhang H; Wolters PJ; Killeen NP; Sullivan BM; Locksley RM; Lowell CA; Caughey GH. 2006. Neutrophil histamine contributes to inflammation in mycoplasma pneumonia. J Exp Med 203(13):2907-17. [PubMed: 17158962]  [MGI Ref ID J:124596]

Yamagishi H; Mochizuki Y; Hamakubo T; Obata K; Ugajin T; Sato S; Kawano Y; Minegishi Y; Karasuyama H. 2011. Basophil-derived mouse mast cell protease 11 induces microvascular leakage and tissue edema in a mast cell-independent manner. Biochem Biophys Res Commun 415(4):709-13. [PubMed: 22086176]  [MGI Ref ID J:178610]

Yamasaki S; Takase-Utsugi M; Ishikawa E; Sakuma M; Nishida K; Saito T; Kanagawa O. 2008. Selective impairment of FcepsilonRI-mediated allergic reaction in Gads-deficient mice. Int Immunol 20(10):1289-97. [PubMed: 18664516]  [MGI Ref ID J:140219]

Yang W; Rudick CN; Hoxha E; Allsop SA; Dimitrakoff JD; Klumpp DJ. 2012. Ca(2+)/calmodulin-dependent protein kinase II is associated with pelvic pain of neurogenic cystitis. Am J Physiol Renal Physiol 303(3):F350-6. [PubMed: 22647634]  [MGI Ref ID J:188438]

Yu M; Eckart MR; Morgan AA; Mukai K; Butte AJ; Tsai M; Galli SJ. 2011. Identification of an IFN-gamma/mast cell axis in a mouse model of chronic asthma. J Clin Invest 121(8):3133-43. [PubMed: 21737883]  [MGI Ref ID J:176170]

Yu M; Tsai M; Tam SY; Jones C; Zehnder J; Galli SJ. 2006. Mast cells can promote the development of multiple features of chronic asthma in mice. J Clin Invest 116(6):1633-41. [PubMed: 16710480]  [MGI Ref ID J:110366]

Zabel BA; Nakae S; Zuniga L; Kim JY; Ohyama T; Alt C; Pan J; Suto H; Soler D; Allen SJ; Handel TM; Song CH; Galli SJ; Butcher EC. 2008. Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis. J Exp Med 205(10):2207-20. [PubMed: 18794339]  [MGI Ref ID J:140110]

Zaiss DM; van Loosdregt J; Gorlani A; Bekker CP; Grone A; Sibilia M; van Bergen En Henegouwen PM; Roovers RC; Coffer PJ; Sijts AJ. 2013. Amphiregulin Enhances Regulatory T Cell-Suppressive Function via the Epidermal Growth Factor Receptor. Immunity 38(2):275-84. [PubMed: 23333074]  [MGI Ref ID J:193394]

Zhang J; Chen H; Liu L; Sun J; Shi MA; Sukhova GK; Shi GP. 2012. Chemokine (C-C motif) receptor 2 mediates mast cell migration to abdominal aortic aneurysm lesions in mice. Cardiovasc Res 96(3):543-51. [PubMed: 22871590]  [MGI Ref ID J:210082]

Zhang J; Sun J; Lindholt JS; Sukhova GK; Sinnamon M; Stevens RL; Adachi R; Libby P; Thompson RW; Shi GP. 2011. Mast cell tryptase deficiency attenuates mouse abdominal aortic aneurysm formation. Circ Res 108(11):1316-27. [PubMed: 21493897]  [MGI Ref ID J:185697]

Zhang L; Oh SY; Wu X; Oh MH; Wu F; Schroeder JT; Takemoto CM; Zheng T; Zhu Z. 2010. SHP-1 deficient mast cells are hyperresponsive to stimulation and critical in initiating allergic inflammation in the lung. J Immunol 184(3):1180-90. [PubMed: 20042576]  [MGI Ref ID J:159529]

Zhang W; Chancey AL; Tzeng HP; Zhou Z; Lavine KJ; Gao F; Sivasubramanian N; Barger PM; Mann DL. 2011. The development of myocardial fibrosis in transgenic mice with targeted overexpression of tumor necrosis factor requires mast cell-fibroblast interactions. Circulation 124(19):2106-16. [PubMed: 22025605]  [MGI Ref ID J:189449]

Zhou JS; Xing W; Friend DS; Austen KF; Katz HR. 2007. Mast cell deficiency in Kit(W-sh) mice does not impair antibody-mediated arthritis. J Exp Med 204(12):2797-802. [PubMed: 17998392]  [MGI Ref ID J:128512]

Zhou L; Oh SY; Zhou Y; Yuan B; Wu F; Oh MH; Wang Y; Takemoto C; Van Rooijen N; Zheng T; Zhu Z. 2013. SHP-1 regulation of mast cell function in allergic inflammation and anaphylaxis. PLoS One 8(2):e55763. [PubMed: 23390550]  [MGI Ref ID J:197214]

de Vries MR; Wezel A; Schepers A; van Santbrink PJ; Woodruff TM; Niessen HW; Hamming JF; Kuiper J; Bot I; Quax PH. 2013. Complement factor C5a as mast cell activator mediates vascular remodelling in vein graft disease. Cardiovasc Res 97(2):311-20. [PubMed: 23071133]  [MGI Ref ID J:210290]

de Vries VC; Pino-Lagos K; Nowak EC; Bennett KA; Oliva C; Noelle RJ. 2011. Mast cells condition dendritic cells to mediate allograft tolerance. Immunity 35(4):550-61. [PubMed: 22035846]  [MGI Ref ID J:177851]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX11

Colony Maintenance

Breeding & HusbandryHomozygotes are fertile and produce normal litters.
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $182.00Female or MaleHomozygous for KitW-sh  
Price per Pair (US dollars $)Pair Genotype
$364.00Homozygous for KitW-sh x Homozygous for KitW-sh  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Cryopreserved

Frozen Products

Price (US dollars $)
Frozen Embryo $1650.00

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $236.60Female or MaleHomozygous for KitW-sh  
Price per Pair (US dollars $)Pair Genotype
$473.20Homozygous for KitW-sh x Homozygous for KitW-sh  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Cryopreserved

Frozen Products

Price (US dollars $)
Frozen Embryo $2145.00

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

General Supply Notes

  • View the complete collection of spontaneous mutants in the Mouse Mutant Resource.

Control Information

  Control
   000664 C57BL/6J (approximate)
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Important Note

In 2010, The Jackson Laboratory performed a 126 single nucleotide polymorphism analysis on all pedigree lines of KitW-sh mice from Stock No. 005051. This revealed 14/126 markers that were homozygous C3H/He allele-type (two on Chr 5 [including the marker at 76.4 Mbp; closest to the Kit locus], three on Chr 6, one on Chr 8, two on Chr 12, two on Chr 13, one on Chr 15, two on Chr 16, one on Chr 18). Additionally, two markers were segregating for C57BL/6 and C3H/He allele-type (one on Chr 6, one on Chr 16). The amount of 101/H markers present (if any) was not determined. These data show Stock No. 005051 to be only ~87% C57BL/6-genetic background; and suggests it was not completely backcrossed to C57BL/6 prior to arrival in 2004. Therefore, we also offer a fully C57BL/6J-congenic KitW-sh model (Stock No. 012861) for studying KitW-sh on a C57BL/6J genetic background.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


(6.8)