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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
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Description
Strain Information
Type Inbred Strain; Additional information on Inbred Strains. Species laboratory mouse H2 Haplotype z Generation ?+F6 (06-DEC-07) Appearance
agouti
Related Genotype: A/ADescription
Male NZL/LtJ mice develop juvenile-onset obesity and maturity-onset hyperglycemia (McInerney MF, et al., 2004). Over 90% of males exhibit hyperglycemia of >250 mg/dl by 20 weeks of age. Body weight in males increases to 55 gm by 16 weeks of age. The diabetic phenotype is very similar to that of NZO/HlLt J (Stock No. 002105) mice. An advantage of NZL/LtJ over NZO/HlLtJ as a diabetes model, in addition to the higher disease incidence, is that mice of this strain breed well, whereas NZO/HlLt mice breed very poorly.This strain carries the wildtype Igh-6 allele from the NZO/HlLtJ strain.
Development
This strain was developed in parallel with NZL.129S2-Igh-6tm1Cgn/Lt. The Igh-6tm1Cgn targeted allele was obtained by Dr. Edward Leiter at N11 on the NZB/Hl background, to which it had been transferred from B6.129S2-Igh-6tm1Cgn. In Dr. Leiter's laboratory, the mutation was backcrossed onto the NZO/HlLt strain for 5 generations. The N5 Igh-6tm1Cgn heterozygotes were intercrossed, and two sublines were initiated from the progeny: Mice homozygous for the targeted mutation were selected to generate a homozygous Igh-6tm1Cgn line, and mice homozygous for the wildtype Igh-6 allele were chosen to start a parallel wildtype line.As backcrossing was carried out for only 5 generations, the genome of these strains is, statistically, approximately 3.12% of NZB origin with known genetic regions on chromosones 9 and 18; there may also be minor contributions from C57BL/6 and 129S2/SvPas. The control line was found to have a severe diabetes phenotype comparable to that of the NZO/HlLt background strain, but to have certain advantages over the latter. For this reason, the new line was assigned its own inbred-strain nomenclature once it had reached the equivalent of 20 generations of sibling inbreeding.
Genome scan data is available on Dr. Leiter's website. This strain was donated to The Jackson Laboratory in 2004.
Additional Web Information
Genetic Quality Control Annual Report
Phenotype
Phenotype Information
View Research Applications
Research Applications
This mouse can be used to support research in many areas including:
Diabetes and Obesity Research
Hyperglycemia (adult onset, males)
Obesity With Diabetes (males)
Type 2 Diabetes (NIDDM) (males)
Genes & Alleles
Gene & Allele Information
Currently there are no related genes or alleles for this strain.Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Optimizing PCR Protocols
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX12
Colony Maintenance
Diet Information LabDiet® 5K54
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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*Price(s) in US dollars ($)
Weeks of Age Price* Gender Individual Mouse Price $88.10 Female or Male
Additional Supply Details
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| Pricing for International shipping destinations |
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*Price(s) in US dollars ($)
Weeks of Age Price* Gender Individual Mouse Price $114.60 Female or Male
Additional Supply Details
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement. |
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General Terms and Conditions
See Terms of Use
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
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