Description

Strain Information

Type Inbred Strain; Additional information on Inbred Strains. Visit our online Nomenclature tutorial. Species laboratory mouse H2 Haplotype z Generation ?+F14 (06-JAN-11) Generation Definitions

Appearance
agouti
Related Genotype: A/A

Description
Male NZL/LtJ mice develop juvenile-onset obesity and maturity-onset hyperglycemia (McInerney MF, et al., 2004). Over 90% of males exhibit hyperglycemia of >250 mg/dl by 20 weeks of age. Body weight in males increases to 55 gm by 16 weeks of age. The diabetic phenotype is very similar to that of NZO/HlLt J (Stock No. 002105) mice. An advantage of NZL/LtJ over NZO/HlLtJ as a diabetes model, in addition to the higher disease incidence, is that mice of this strain breed well, whereas NZO/HlLt mice breed very poorly.

This strain carries the wildtype Ighm allele from the NZO/HlLtJ strain.

Development
This strain was developed in parallel with NZL.129S2-Ighm^tm1Cgn/Lt. The Ighm^tm1Cgn targeted allele was obtained by Dr. Edward Leiter at N11 on the NZB/Hl background, to which it had been transferred from B6.129S2-Ighm^tm1Cgn. In Dr. Leiter's laboratory, the mutation was backcrossed onto the NZO/HlLt strain for 5 generations. The N5 Ighm^tm1Cgn heterozygotes were intercrossed, and two sublines were initiated from the progeny: Mice homozygous for the targeted mutation were selected to generate a homozygous Ighm^tm1Cgn line, and mice homozygous for the wildtype Ighm allele were chosen to start a parallel wildtype line.

As backcrossing was carried out for only 5 generations, the genome of these strains is, statistically, approximately 3.12% of NZB origin with known genetic regions on chromosones 9 and 18; there may also be minor contributions from C57BL/6 and 129S2/SvPas. The control line was found to have a severe diabetes phenotype comparable to that of the NZO/HlLt background strain, but to have certain advantages over the latter. For this reason, the new line was assigned its own inbred-strain nomenclature once it had reached the equivalent of 20 generations of sibling inbreeding.

Genome scan data is available on Dr. Leiter's website. This strain was donated to The Jackson Laboratory in 2004.

Additional Web Information

Genetic Quality Control Annual Report

Phenotype

Phenotype Information

View Phenotypic Data

Phenotypic Data

Mouse Phenome Database

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Diabetes and Obesity Research
Hyperglycemia
      adult onset, males
Obesity With Diabetes
      males
Type 2 Diabetes (NIDDM)
      males

Genes & Alleles

Gene & Allele Information provided by MGI

Currently there are no related genes or alleles for this strain.

Genotyping

Genotyping Information

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Currently there are no available references for this strain.

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX12

Colony Maintenance

Diet Information	LabDiet® 5K54

Purchasing information

Pricing, Supply Level & Notes, Controls

General Supply Notes

• This strain is included in the Mouse Mutant Resource collection.
• Genomic DNA is available for this strain from the Mouse DNA Resource.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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