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Common Names: aP2-Cre;    
The FABP4-Cre transgene has a mouse Fabp4 promoter directing expression of Cre recombinase. These FABP4-Cre transgenic mice are a Cre-lox tool useful for deletion of floxed sequences in brown and white adipose tissue.


Strain Information

Type Congenic; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
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Additional information on Congenic nomenclature.
Mating SystemInbred x Hemizygote         (Female x Male)   01-MAR-06
Specieslaboratory mouse
GenerationN9+N21 (28-DEC-13)
Generation Definitions
Donating Investigator Ronald M. Evans,   The Salk Inst for Biological Studies

These transgenic mice express Cre recombinase under the control of the mouse Fabp4 promoter. Cre recombinase expression is detected in brown and white gonadal and subcutaneous adipose tissue. No expression is detected in skeletal muscle. When crossed with a strain containing a loxP site flanked sequence of interest, Cre-mediated recombination results in deletion of the targeted gene specifically in adipose tissue. Mice that are homozygous for the targeted mutation are viable. This strain represents an effective tool for generating tissue-specific targeted mutants.

View cre expression characterization.

A transgenic construct containing cre coding sequence under the control of the 5.4 kbp Fabp4 promoter was introduced into unknown outbred donor eggs. The resulting male transgenic mice were crossed to B6.129-Ppargtm2Rev/J (Stock No. 004584) mice and subsequently crossed to C57BL/6J mice for nine generations in the laboratory of Dr. Yaacov Barak at The Jackson Laboratory. The Ppargtm2Rev/J allele was bred out of the strain during the backcrossing to C57BL/6J.

Control Information

  Considerations for Choosing Controls

Related Strains

Strains carrying   Tg(Fabp4-cre)1Rev allele
018965   B6N.Cg-Tg(Fabp4-cre)1Rev/J
View Strains carrying   Tg(Fabp4-cre)1Rev     (1 strain)

View Strains carrying other alleles of Fabp4     (5 strains)

Strains carrying other alleles of cre
004337   129(Cg)-Foxg1tm1(cre)Skm/J
008569   129-Alpltm1(cre)Nagy/J
005989   129;FVB-Tg(PTH-cre)4167Slib/J
007179   129S.Cg-Tg(UBC-cre/ERT2)1Ejb/J
007915   129S.FVB-Tg(Amh-cre)8815Reb/J
003328   129S/Sv-Tg(Prm-cre)58Og/J
026200   129S1.Cg-Tg(Vsx2-cre)2690Chow/J
004302   129S1/Sv-Hprttm1(cre)Mnn/J
022137   129S4.Cg-Tg(Wnt1-cre)2Sor/J
003960   129S6-Tg(Prnp-GFP/cre)1Blw/J
008523   129S6.Cg-Tg(NPHS2-cre)295Lbh/BroJ
009587   B6(129S4)-Et(icre)1402Rdav/J
009588   B6(129S4)-Et(icre)1470Rdav/J
009589   B6(129S4)-Et(icre)1555Rdav/J
009586   B6(129S4)-Et(icre)754Rdav/J
012687   B6(129S4)-Tg(SYN1-icre/mRFP1)9934Rdav/J
010774   B6(Cg)-Calb2tm1(cre)Zjh/J
017562   B6(Cg)-Cd8atm1.1(cre)Koni/J
012704   B6(Cg)-Crhtm1(cre)Zjh/J
018448   B6(Cg)-Foxn1tm3(cre)Nrm/J
026801   B6(Cg)-Ins1tm1.1(cre)Thor/J
016223   B6(Cg)-Tg(Phox2b-cre)3Jke/J
016829   B6(SJL)-Pou5f1tm1.1(cre/Esr1*)Yseg/J
016959   B6.129(Cg)-Foxp3tm4(YFP/cre)Ayr/J
023055   B6.129(Cg)-Krt12tm3(cre)Wwk/J
008320   B6.129-Leprtm2(cre)Rck/J
017526   B6.129-Nos1tm1(cre)Mgmj/J
005697   B6.129-Otx1tm4(cre)Asim/J
018938   B6.129-Tac2tm1.1(cre)Qima/J
017769   B6.129-Trpv1tm1(cre)Bbm/J
004146   B6.129-Tg(Pcp2-cre)2Mpin/J
008710   B6.129P2(129S4)-Hprttm10(Ple162-EGFP/cre)Ems/Mmjax
008877   B6.129P2(129S4)-Hprttm12(Ple177-EGFP/cre)Ems/Mmjax
009116   B6.129P2(129S4)-Hprttm16(Ple167-EGFP/cre)Ems/Mmjax
008709   B6.129P2(129S4)-Hprttm9(Ple178-EGFP/cre)Ems/Mmjax
006785   B6.129P2(C)-Cd19tm1(cre)Cgn/J
006084   B6.129P2(Cg)-Foxg1tm1(cre)Skm/J
010611   B6.129P2(Cg)-Ighg1tm1(IRES-cre)Cgn/J
007770   B6.129P2-Aicdatm1(cre)Mnz/J
004781   B6.129P2-Lyz2tm1(cre)Ifo/J
017320   B6.129P2-Pvalbtm1(cre)Arbr/J
017915   B6.129S(Cg)-Pgrtm1.1(cre)Shah/AndJ
013594   B6.129S-Atoh1tm5.1(Cre/PGR)Hzo/J
021794   B6.129S1(Cg)-Ascl3tm1.1(EGFP/cre)Ovi/J
024637   B6.129S1(SJL)-Nkx2-5tm2(cre)Rph/J
006600   B6.129S1-Mnx1tm4(cre)Tmj/J
005628   B6.129S2-Emx1tm1(cre)Krj/J
022510   B6.129S4-Gpr88tm1.1(cre/GFP)Rpa/J
017578   B6.129S4-Mcpt8tm1(cre)Lky/J
003755   B6.129S4-Meox2tm1(cre)Sor/J
007893   B6.129S4-Myf5tm3(cre)Sor/J
006878   B6.129S6-Taglntm2(cre)Yec/J
012839   B6.129X1(Cg)-Tnfrsf4tm2(cre)Nik/J
008712   B6.129X1-Twist2tm1.1(cre)Dor/J
006054   B6.C-Tg(CMV-cre)1Cgn/J
020811   B6.C-Tg(Pgk1-cre)1Lni/CrsJ
023530   B6.Cg-Avptm1.1(cre)Hze/J
013590   B6.Cg-Braftm1Mmcm Ptentm1Hwu Tg(Tyr-cre/ERT2)13Bos/BosJ
006230   B6.Cg-Cebpatm1Dgt Tg(Mx1-cre)1Cgn/J
012358   B6.Cg-Pvalbtm1.1(cre)Aibs/J
005622   B6.Cg-Shhtm1(EGFP/cre)Cjt/J
022762   B6.Cg-Zfp335tm1.2Caw Emx1tm1(cre)Krj/J
017346   B6.Cg-Tg(A930038C07Rik-cre)1Aibs/J
006149   B6.Cg-Tg(ACTA1-cre)79Jme/J
003574   B6.Cg-Tg(Alb-cre)21Mgn/J
006881   B6.Cg-Tg(Aqp2-cre)1Dek/J
011104   B6.Cg-Tg(Atoh1-cre)1Bfri/J
004682   B6.Cg-Tg(CAG-cre/Esr1*)5Amc/J
008520   B6.Cg-Tg(CD2-cre)4Kio/J
009350   B6.Cg-Tg(CDX2-cre)101Erf/J
009352   B6.Cg-Tg(CDX2-cre*)189Erf/J
027310   B6.Cg-Tg(Camk2a-cre)2Szi/J
027400   B6.Cg-Tg(Camk2a-cre)3Szi/J
005359   B6.Cg-Tg(Camk2a-cre)T29-1Stl/J
022071   B6.Cg-Tg(Cd4-cre)1Cwi/BfluJ
012237   B6.Cg-Tg(Cdh16-cre)91Igr/J
006368   B6.Cg-Tg(Cr2-cre)3Cgn/J
008538   B6.Cg-Tg(Cspg4-cre/Esr1*)BAkik/J
006663   B6.Cg-Tg(Eno2-cre)39Jme/J
012712   B6.Cg-Tg(Fev-cre)1Esd/J
012849   B6.Cg-Tg(GFAP-cre/ERT2)505Fmv/J
012886   B6.Cg-Tg(Gfap-cre)73.12Mvs/J
024098   B6.Cg-Tg(Gfap-cre)77.6Mvs/2J
009642   B6.Cg-Tg(Gh1-cre)1Sac/J
024474   B6.Cg-Tg(Il9-cre)#Stck/J
003573   B6.Cg-Tg(Ins2-cre)25Mgn/J
008068   B6.Cg-Tg(Itgax-cre)1-1Reiz/J
008781   B6.Cg-Tg(Kap-cre)29066/2Sig/J
003802   B6.Cg-Tg(Lck-cre)548Jxm/J
006889   B6.Cg-Tg(Lck-cre)I540Jxm/J
012837   B6.Cg-Tg(Lck-icre)3779Nik/J
009643   B6.Cg-Tg(Lhb-cre)1Sac/J
008330   B6.Cg-Tg(Mc4r-cre)25Rck/J
003556   B6.Cg-Tg(Mx1-cre)1Cgn/J
007742   B6.Cg-Tg(Myh11-cre,-EGFP)2Mik/J
008205   B6.Cg-Tg(NPHS2-cre)295Lbh/J
003771   B6.Cg-Tg(Nes-cre)1Kln/J
010536   B6.Cg-Tg(Pcp2-cre)3555Jdhu/J
005975   B6.Cg-Tg(Plp1-cre/ERT)3Pop/J
008827   B6.Cg-Tg(Prdm1-cre)1Masu/J
005584   B6.Cg-Tg(Prrx1-cre)1Cjt/J
003967   B6.Cg-Tg(Rbp3-cre)528Jxm/J
021614   B6.Cg-Tg(S100A8-cre,-EGFP)1Ilw/J
008454   B6.Cg-Tg(Sox2-cre)1Amc/J
006361   B6.Cg-Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/J
003966   B6.Cg-Tg(Syn1-cre)671Jxm/J
017491   B6.Cg-Tg(Tagln-cre)1Her/J
004128   B6.Cg-Tg(Tek-cre)12Flv/J
008863   B6.Cg-Tg(Tek-cre)1Ywa/J
008601   B6.Cg-Tg(Th-cre)1Tmd/J
012328   B6.Cg-Tg(Tyr-cre/ERT2)13Bos/J
008085   B6.Cg-Tg(UBC-cre/ERT2)1Ejb/J
008610   B6.Cg-Tg(Vav1-cre)A2Kio/J
004586   B6.Cg-Tg(Vil-cre)997Gum/J
021504   B6.Cg-Tg(Vil1-cre)1000Gum/J
008735   B6.Cg-Tg(Wap-cre)11738Mam/JKnwJ
009614   B6.Cg-Tg(Wfs1-cre/ERT2)2Aibs/J
009107   B6.Cg-Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J
022501   B6.Cg-Tg(Wnt1-cre)2Sor/J
006234   B6.Cg-Tg(tetO-cre)1Jaw/J
016832   B6.FVB(129)-Tg(Alb1-cre)1Dlr/J
005657   B6.FVB(129)-Tg(Myh6-cre/Esr1*)1Jmk/J
024688   B6.FVB(129S)-Tg(Pax6-GFP/cre)1Rilm/J
006475   B6.FVB(129S4)-Tg(Ckmm-cre)5Khn/J
006451   B6.FVB(129X1)-Tg(Sim1-cre)1Lowl/J
006333   B6.FVB(Cg)-Tg(Neurog3-cre)C1Able/J
014643   B6.FVB-Tg(CMA1-cre)6Thhe/J
006137   B6.FVB-Tg(Cdh5-cre)7Mlia/J
018980   B6.FVB-Tg(Ddx4-cre)1Dcas/KnwJ
003724   B6.FVB-Tg(EIIa-cre)C5379Lmgd/J
011069   B6.FVB-Tg(Gh1-cre)bKnmn/J
011038   B6.FVB-Tg(Myh6-cre)2182Mds/J
014647   B6.FVB-Tg(Pdx1-cre)6Tuv/J
010714   B6.FVB-Tg(Pomc-cre)1Lowl/J
022791   B6.FVB-Tg(Rorc-cre)1Litt/J
017535   B6.FVB-Tg(Slc32a1-cre)2.1Hzo/FrkJ
017490   B6.FVB-Tg(Stra8-icre)1Reb/LguJ
024670   B6.FVB-Tg(Ucp1-cre)1Evdr/J
003394   B6.FVB-Tg(Zp3-cre)3Mrt/J
006660   B6.SJL-Slc6a3tm1.1(cre)Bkmn/J
003552   B6129-Tg(Wap-cre)11738Mam/J
023161   B6129S-Tg(Foxp3-EGFP/cre)1aJbs/J
021025   B6;129-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm1(tetO-cre)Haho/J
010529   B6;129-Myf5tm1(cre)Mrc/J
010528   B6;129-Myf6tm2(cre)Mrc/J
017525   B6;129-Ntstm1(cre)Mgmj/J
005549   B6;129-Pax3tm1(cre)Joe/J
017968   B6;129-Tg(Cdh5-cre)1Spe/J
024860   B6;129-Tg(Drd1-cre)120Mxu/Mmjax
010988   B6;129P-Cyp11a1tm1(GFP/cre)Pzg/J
008529   B6;129P-Tg(Neurog1-cre/ERT2)1Good/J
012601   B6;129P2-Lyve1tm1.1(EGFP/cre)Cys/J
006668   B6;129P2-Omptm4(cre)Mom/MomJ
008069   B6;129P2-Pvalbtm1(cre)Arbr/J
012373   B6;129S-Hoxb1tm1(cre)Og/J
024234   B6;129S-Oxttm1.1(cre)Dolsn/J
023526   B6;129S-Rorbtm1.1(cre)Hze/J
023527   B6;129S-Slc17a7tm1.1(cre)Hze/J
023525   B6;129S-Snap25tm2.1(cre)Hze/J
021877   B6;129S-Tac1tm1.1(cre)Hze/J
021878   B6;129S-Tac2tm1.1(cre)Hze/J
017685   B6;129S-Wisp3tm1(cre)Mawa/J
007001   B6;129S-Tg(UBC-cre/ERT2)1Ejb/J
009388   B6;129S1-Osr2tm2(cre)Jian/J
012463   B6;129S4-Foxd1tm1(GFP/cre)Amc/J
011105   B6;129S4-Olig1tm1(cre)Rth/J
006410   B6;129S6-Chattm2(cre)Lowl/J
009616   B6;C3-Tg(A930038C07Rik-cre)4Aibs/J
012433   B6;C3-Tg(ACTA1-rtTA,tetO-cre)102Monk/J
008844   B6;C3-Tg(Ctgf-cre)2Aibs/J
008839   B6;C3-Tg(Cyp39a1-cre)1Aibs/J
009117   B6;C3-Tg(Cyp39a1-cre)7Aibs/J
008848   B6;C3-Tg(Mybpc1-cre)2Aibs/J
009111   B6;C3-Tg(Scnn1a-cre)1Aibs/J
009112   B6;C3-Tg(Scnn1a-cre)2Aibs/J
009613   B6;C3-Tg(Scnn1a-cre)3Aibs/J
009103   B6;C3-Tg(Wfs1-cre/ERT2)3Aibs/J
025806   B6;CBA-Tg(Gsx2-cre)1Kess/J
026555   B6;CBA-Tg(Lhx6-cre)1Kess/J
025807   B6;CBA-Tg(Sox10-cre)1Wdr/J
024507   B6;CBA-Tg(Tbx21-cre)1Dlc/J
017494   B6;D-Tg(Tshz3-GFP/cre)43Amc/J
024926   B6;D2-Tg(Fshr-cre)1Ldu/J
003466   B6;D2-Tg(Sycp1-cre)4Min/J
014160   B6;DBA-Tg(S100b-EGFP/cre/ERT2)22Amc/J
014159   B6;DBA-Tg(Tmem100-EGFP/cre/ERT2)30Amc/J
015855   B6;DBA-Tg(Upk3a-GFP/cre/ERT2)26Amc/J
010803   B6;FVB-Tg(Adipoq-cre)1Evdr/J
018422   B6;FVB-Tg(Aicda-cre)1Rcas/J
023748   B6;FVB-Tg(Aldh1l1-cre)JD1884Gsat/J
011087   B6;FVB-Tg(Crh-cre)1Kres/J
008533   B6;FVB-Tg(Cspg4-cre)1Akik/J
003734   B6;FVB-Tg(GZMB-cre)1Jcb/J
015850   B6;SJL-Pde6b+ Tg(Rho-icre)1Ck/Boc
004426   B6;SJL-Tg(Cga-cre)3Sac/J
003554   B6;SJL-Tg(Col2a1-cre)1Bhr/J
017738   B6;SJL-Tg(Foxl1-cre)1Khk/J
005249   B6;SJL-Tg(Krt1-15-cre/PGR)22Cot/J
019893   B6;SJL-Tg(Tex101-icre)2Lzj/J
007252   B6Ei.129S4-Tg(Prm-cre)58Og/EiJ
025524   B6J.B6N(Cg)-Cx3cr1tm1.1(cre)Jung/J
018956   B6N.129P2(B6)-Lyz2tm1(cre)Ifo/J
018958   B6N.129P2-Cd19tm1(cre)Cgn/J
021077   B6N.129S1-Mrgprb4tm3(cre)And/J
018957   B6N.129S6(B6)-Chattm2(cre)Lowl/J
017911   B6N.129S6(Cg)-Esr1tm1.1(cre)And/J
019013   B6N.129S6(Cg)-Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
018974   B6N.B6-Tg(Nr4a1-EGFP/cre)820Khog/J
019021   B6N.Cg-Ccktm1.1(cre)Zjh/J
019022   B6N.Cg-Gad2tm2(cre)Zjh/J
018973   B6N.Cg-Ssttm2.1(cre)Zjh/J
018961   B6N.Cg-Tg(Alb-cre)21Mgn/J
019102   B6N.Cg-Tg(CAG-cre/Esr1*)5Amc/CjDswJ
018966   B6N.Cg-Tg(Camk2a-cre)T29-1Stl/J
017310   B6N.Cg-Tg(Hsd17b1-icre/ERT2)3Casa/J
018960   B6N.Cg-Tg(Ins2-cre)25Mgn/J
018967   B6N.Cg-Tg(Itgax-cre)1-1Reiz/J
018964   B6N.Cg-Tg(KRT14-cre)1Amc/J
019103   B6N.Cg-Tg(Nes-cre)1Kln/CjDswJ
014094   B6N.Cg-Tg(Sox2-cre)1Amc/J
018968   B6N.Cg-Tg(Vav1-cre)A2Kio/J
018963   B6N.Cg-Tg(Vil-cre)997Gum/J
018972   B6N.FVB(B6)-Tg(Myh6-cre)2182Mds/J
019099   B6N.FVB-Tg(ACTB-cre)2Mrt/CjDswJ
019509   B6N.FVB-Tg(BGLAP-cre)1Clem/J
023047   B6N.FVB-Tg(Dmp1-cre)1Jqfe/BwdJ
017927   B6N.FVB-Tg(Mpz-cre)26Mes/J
003465   BALB/c-Tg(CMV-cre)1Cgn/J
012641   BALB/c-Tg(S100a4-cre)1Egn/YunkJ
010612   C.129P2(Cg)-Ighg1tm1(IRES-cre)Cgn/J
017353   C.129S4(B6)-Il13tm1(YFP/cre)Lky/J
017582   C.129S4(B6)-Mcpt8tm1(cre)Lky/J
004126   C.Cg-Cd19tm1(cre)Cgn Ighb/J
005673   C.Cg-Tg(Mx1-cre)1Cgn/J
006244   C.Cg-Tg(tetO-cre)1Jaw/J
009155   C57BL/6-Cldn6tm1(cre)Dkwu/J
017557   C57BL/6-Tg(BEST1-cre)1Jdun/J
027406   C57BL/6-Tg(CD2-cre)1Lov/J
016097   C57BL/6-Tg(Car1-cre)5Flt/J
011086   C57BL/6-Tg(Cck-cre)CKres/J
008766   C57BL/6-Tg(Cd8a-cre)1Itan/J
026828   C57BL/6-Tg(Cpa3-cre)4Glli/J
006474   C57BL/6-Tg(Grik4-cre)G32-4Stl/J
008314   C57BL/6-Tg(HBB-cre)12Kpe/J
008870   C57BL/6-Tg(Hspa2-cre)1Eddy/J
016261   C57BL/6-Tg(Nes-cre/ERT2)KEisc/J
012906   C57BL/6-Tg(Nes-cre/Esr1*)1Kuan/J
027205   C57BL/6-Tg(Nms-icre)20Ywa/J
016617   C57BL/6-Tg(Nr4a1-EGFP/cre)820Khog/J
020287   C57BL/6-Tg(Pbsn-cre/Esr1*)14Abch/J
013148   C57BL/6-Tg(Pdgfra-cre)1Clc/J
008535   C57BL/6-Tg(Pf4-cre)Q3Rsko/J
024034   C57BL/6-Tg(Pmch-cre)1Rck/J
016583   C57BL/6-Tg(Slc6a3-icre/ERT2)2Gloss/J
006888   C57BL/6-Tg(Zp3-cre)1Gwh/J
003651   C57BL/6-Tg(Zp3-cre)93Knw/J
021119   C57BL/6J-Tg(Dlx2-cre,-mCherry)4Grsr/GrsrJ
021423   C57BL/6J-Tg(Dlx2-cre,-mCherry)9Grsr/GrsrJ
007567   C57BL/6J-Tg(Itgax-cre,-EGFP)4097Ach/J
018895   C57BL/6J-Tg(Krt6,-cre,-Cerulean)1Grsr/Grsr
018896   C57BL/6J-Tg(Krt6,-cre,-Cerulean)2Grsr/Grsr
018898   C57BL/6J-Tg(Krt6,-cre,-Cerulean)4Grsr/Grsr
018899   C57BL/6J-Tg(Krt6,-cre,-Cerulean)5Grsr/Grsr
021582   C57BL/6J-Tg(Mchr1-cre)1Emf/J
008661   C57BL/6J-Tg(Nkx2-1-cre)2Sand/J
022883   C57BL/6J-Tg(Six6-cre)3Grsr/GrsrJ
022887   C57BL/6J-Tg(Six6-cre)7Grsr/GrsrJ
018754   C57BL/6J-Tg(Tbx22,-cre,-mCherry)1Grsr/GrsrJ
019363   C57BL/6J-Tg(Trp63,-cre,-Cerulean)10Grsr/Grsr
018792   C57BL/6J-Tg(Trp63,-cre,-Cerulean)4Grsr/GrsrJ
003650   C57BL/6J-Tg(Zp3-cre)82Knw/KnwJ
018151   C57BL/6N-Krt17tm1(cre,Cerulean)Murr/GrsrJ
023014   C57BL/6N-Tg(Calcrl,cre)4688Nkza/J
012686   C57BL/6N-Tg(Ppp1r2-cre)4127Nkza/J
016582   C57BL/6N-Tg(Slc32a1-icre/ERT2)3Gloss/J
026861   D2.129P2(B6)-Lyz2tm1(cre)Ifo/SjJ
026858   D2.129S4(B6)-Meox2tm1(cre)Sor/SjJ
026266   D2.B6-Tg(Zp3-cre)93Knw/SjJ
026852   D2.Cg-Tg(Gfap-cre)73.12Mvs/SjJ
024701   D2.Cg-Tg(Plp1-cre/ERT)3Pop/SjJ
026859   D2.Cg-Tg(Sox2-cre)1Amc/SjJ
026857   D2.FVB-Tg(GFAP-cre)25Mes/SjJ
026860   D2.FVB-Tg(Tek-cre)2352Rwng/SjJ
016833   FVB(Cg)-Tg(Alb1-cre)1Dlr/J
012929   FVB(Cg)-Tg(Dhh-cre)1Mejr/J
011034   FVB(Cg)-Tg(Ghrhr-cre)3242Lsk/J
006405   FVB-Tg(Ckmm-cre)5Khn/J
021024   FVB-Tg(Csf1r-icre)1Jwp/J
006954   FVB-Tg(Ddx4-cre)1Dcas/J
004600   FVB-Tg(GFAP-cre)25Mes/J
011037   FVB-Tg(Myh6-cre)2182Mds/J
006364   FVB-Tg(Nr5a1-cre)2Lowl/J
008537   FVB-Tg(Tek-cre)2352Rwng/J
019382   FVB.Cg-Myh9tm1.1Gac Tg(NPHS2-cre)295Lbh/Mmjax
014140   FVB.Cg-Myod1tm2.1(icre)Glh/J
006139   FVB.Cg-Tg(ACTA1-cre)79Jme/J
017595   FVB.Cg-Tg(CAG-cre/Esr1*)5Amc/J
006297   FVB.Cg-Tg(Eno2-cre)39Jme/J
018394   FVB.Cg-Tg(KRT5-cre/ERT2)2Ipc/JeldJ
008244   FVB.Cg-Tg(tetO-cre)1Jaw/J
003376   FVB/N-Tg(ACTB-cre)2Mrt/J
024384   FVB/N-Tg(AMELX-cre)A1Kul/J
003314   FVB/N-Tg(EIIa-cre)C5379Lmgd/J
025062   FVB/N-Tg(Figla-EGFP,-icre)ZP3Dean/Mmjax
017928   FVB/N-Tg(Mpz-cre)26Mes/J
025066   FVB/N-Tg(Mylpf-cre)3Kraj/Mmjax
006143   FVB/N-Tg(Thy1-cre)1Vln/J
003377   FVB/N-Tg(Zp3-cre)3Mrt/J
023325   FVB;B6-Tg(Pbsn-cre)20Fwan/J
019096   NOD.129P2(B6)-Lyz2tm1(cre)Ifo/NadlJ
023806   NOD.129P2(Cg)-Cd19tm1(cre)Cgn/J
013233   NOD.B6-Tg(Itgax-cre,-EGFP)4097Ach/J
013234   NOD.Cg-Tg(Cd4-cre)1Cwi/2AchJ
023972   NOD.Cg-Tg(Ins2-cre/ERT)1Dam/SbwJ
023203   NOD.Cg-Tg(Itgax-cre)1-1Reiz/PesaJ
005732   NOD.Cg-Tg(Lck-cre)548Jxm/AchJ
023973   NOD.Cg-Tg(Neurog3-cre)1Dam/SbwJ
013251   NOD.FVB-Tg(EIIa-cre)C5379Lmgd/J
008694   NOD/ShiLt-Tg(Foxp3-EGFP/cre)1cJbs/J
004986   NOD/ShiLt-Tg(Ins2-cre)3Lt/LtJ
003855   NOD/ShiLt-Tg(Ins2-cre)5Lt/LtJ
004987   NOD/ShiLt-Tg(Ins2-cre)6Lt/LtJ
012899   STOCK Agrptm1(cre)Lowl/J
026229   STOCK Akap12tm1Ihg Rb1tm2Brn Tg(Pbsn-cre)4Prb/J
012706   STOCK Ccktm1.1(cre)Zjh/J
010910   STOCK Corttm1(cre)Zjh/J
007916   STOCK En1tm2(cre)Wrst/J
008464   STOCK Foxa2tm2.1(cre/Esr1*)Moon/J
010802   STOCK Gad2tm2(cre)Zjh/J
018903   STOCK Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
023407   STOCK HhatTg(TFAP2A-cre)1Will/J
008876   STOCK Hprttm11(Ple176-EGFP/cre)Ems/Mmjax
016879   STOCK Il17atm1.1(icre)Stck/J
024242   STOCK Isl1tm1(cre)Sev/J
018976   STOCK Kdrtm1(cre)Sato/J
017701   STOCK Kiss1tm1.1(cre/EGFP)Stei/J
007022   STOCK Mnx1tm4(cre)Tmj Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
004192   STOCK Mttptm2Sgy Ldlrtm1Her Apobtm2Sgy Tg(Mx1-cre)1Cgn/J
023342   STOCK Myf5tm1(cre/Esr1*)Trdo/J
024713   STOCK Myl1tm1(cre)Sjb/J
014180   STOCK Myocdtm1(cre)Jomm/J
006953   STOCK Notch1tm3(cre)Rko/J
006677   STOCK Olfr151tm28(cre)Mom/MomJ
011103   STOCK Olig2tm2(TVA,cre)Rth/J
010530   STOCK Pax7tm1(cre)Mrc/J
019378   STOCK Ptf1atm2(cre/ESR1)Cvw/J
016963   STOCK Slc17a6tm2(cre)Lowl/J
016962   STOCK Slc32a1tm2(cre)Lowl/J
013044   STOCK Ssttm2.1(cre)Zjh/J
012719   STOCK Tgfb3tm1(cre)Vk/J
012620   STOCK Trp53tm1Brd Brca1tm1Aash Tg(LGB-cre)74Acl/J
008813   STOCK Trpa1tm2Kykw Tg(CAG-cre/Esr1*)5Amc/J
010908   STOCK Viptm1(cre)Zjh/J
010911   STOCK Wt1tm1(EGFP/cre)Wtp/J
008783   STOCK Tg(CAG-cre/Esr1*)5Amc Smn1tm3(SMN2/Smn1)Mrph Tg(SMN2*delta7)4299Ahmb Tg(SMN2)89Ahmb/J
004453   STOCK Tg(CAG-cre/Esr1*)5Amc/J
009615   STOCK Tg(Cartpt-cre)1Aibs/J
017336   STOCK Tg(Cd4-cre)1Cwi/BfluJ
005105   STOCK Tg(Chx10-EGFP/cre,-ALPP)2Clc/J
008861   STOCK Tg(Ela1-Cre/ERT2)1Stof/J
008852   STOCK Tg(En2-cre)22Alj/J
005938   STOCK Tg(Eno2-cre)39Jme/J
022763   STOCK Tg(Eno2-cre/ERT2)1Pohlk/J
011062   STOCK Tg(Gdf9-cre)5092Coo/J
012841   STOCK Tg(Ggt1-cre)M3Egn/J
021207   STOCK Tg(Gnrh1-cre)1Dlc/J
017981   STOCK Tg(Hoxb6-cre)#Mku/J
004692   STOCK Tg(Hoxb7-cre)13Amc/J
014600   STOCK Tg(I12b-cre/ERT2,-ALPP)37Fsh/J
008122   STOCK Tg(Ins2-cre/ERT)1Dam/J
004782   STOCK Tg(KRT14-cre)1Amc/J
005107   STOCK Tg(KRT14-cre/ERT)20Efu/J
008582   STOCK Tg(Kcnc2-Cre)K128Stl/LetJ
023426   STOCK Tg(Kiss1-cre)J2-4Cfe/J
017836   STOCK Tg(LGB-cre)74Acl/J
003551   STOCK Tg(MMTV-cre)1Mam/J
003553   STOCK Tg(MMTV-cre)4Mam/J
002527   STOCK Tg(Mx1-cre)1Cgn/J
009074   STOCK Tg(Myh6-cre)1Jmk/J
005650   STOCK Tg(Myh6-cre/Esr1*)1Jmk/J
009102   STOCK Tg(Nefh-cre)12Kul/J
002858   STOCK Tg(Nes-cre)1Wme/J
002859   STOCK Tg(Nes-cre)2Wme/J
012859   STOCK Tg(Neurog1-cre)1Jejo/J
005667   STOCK Tg(Neurog3-cre)C1Able/J
008119   STOCK Tg(Neurog3-cre/Esr1*)1Dam/J
012462   STOCK Tg(Nr5a1-cre)7Lowl/J
014158   STOCK Tg(Pax4-cre)1Dam/J
024578   STOCK Tg(Pax6-GFP/cre)1Rilm/J
006207   STOCK Tg(Pcp2-cre)1Amc/J
014099   STOCK Tg(Pmch-cre)1Lowl/J
005965   STOCK Tg(Pomc1-cre)16Lowl/J
012452   STOCK Tg(Rr5-GFP/cre)1Sapc/J
006395   STOCK Tg(Sim1-cre)1Lowl/J
009606   STOCK Tg(Six2-EGFP/cre)1Amc/J
019755   STOCK Tg(Six3-cre)69Frty/GcoJ
018147   STOCK Tg(Slc17a8-icre)1Edw/SealJ
012586   STOCK Tg(Slc1a3-cre/ERT)1Nat/J
004783   STOCK Tg(Sox2-cre)1Amc/J
008208   STOCK Tg(Stra8-icre)1Reb/J
016236   STOCK Tg(TCF/Lef1-cre/ERT2)1Dje/J
004746   STOCK Tg(Tagln-cre)1Her/J
012708   STOCK Tg(Thy1-cre/ERT2,-EYFP)HGfng/PyngJ
024240   STOCK Tg(Tnnt2-cre)5Blh/JiaoJ
016584   STOCK Tg(Tph2-icre/ERT2)6Gloss/J
003829   STOCK Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J
008851   STOCK Tg(Wnt1-cre/ERT)1Alj/J
018281   STOCK Tg(Wnt7a-EGFP/cre)#Bhr/Mmjax
008199   STOCK Tg(dlx6a-cre)1Mekk/J
002471   STOCK Tg(hCMV-cre)140Sau/J
023724   STOCK Tg(mI56i-cre,EGFP)1Kc/J
006224   STOCK Tg(tetO-cre)1Jaw/J
View Strains carrying other alleles of cre     (412 strains)

Additional Web Information

Introduction to Cre-lox technology


Phenotype Information

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Research Applications
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      Mutagenesis and Transgenesis: Cre-lox System

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol Tg(Fabp4-cre)1Rev
Allele Name transgene insertion 1, Ronald M Evans
Allele Type Transgenic (cre- or Flp-expressing)
Common Name(s) FABP4-Cre; aP2-CRE; aP2-Cre1; aP2-CreSI;
Mutation Made By Weiman He,   Texas A&M University
Site of Expressionadipose tissue
Expressed Gene cre, cre recombinase, bacteriophage P1
Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence.
Promoter Fabp4, fatty acid binding protein 4, adipocyte, mouse, laboratory
Driver Note Fabp4
Molecular Note Sequence encoding cre recombinase was adjoined to the Fabp4 promoter, which is active in white and brown adipose tissue. Northern blot analysis and a functional assay showed the transgene to be abundantly expressed in brown and white adipose tissue. Significant expression was not detected in other tissues including skeletal muscle, liver, and heart. [MGI Ref ID J:73557] [MGI Ref ID J:88210]


Genotyping Information

Genotyping Protocols

Generic Cre Melt Curve Analysis, MELT
Generic Cre Melt Curve Analysis, Probe
Generic Cre, Standard PCR

Helpful Links

Genotyping resources and troubleshooting


References provided by MGI

Selected Reference(s)

He W; Barak Y; Hevener A; Olson P; Liao D; Le J; Nelson M; Ong E; Olefsky JM; Evans RM. 2003. Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle. Proc Natl Acad Sci U S A 100(26):15712-7. [PubMed: 14660788]  [MGI Ref ID J:88210]

Additional References

Tg(Fabp4-cre)1Rev related

Adams AC; Yang C; Coskun T; Cheng CC; Gimeno RE; Luo Y; Kharitonenkov A. 2012. The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue. Mol Metab 2(1):31-7. [PubMed: 24024127]  [MGI Ref ID J:221244]

Ahmadian M; Abbott MJ; Tang T; Hudak CS; Kim Y; Bruss M; Hellerstein MK; Lee HY; Samuel VT; Shulman GI; Wang Y; Duncan RE; Kang C; Sul HS. 2011. Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype. Cell Metab 13(6):739-48. [PubMed: 21641555]  [MGI Ref ID J:176083]

Antonson P; Matic M; Portwood N; Kuiper RV; Bryzgalova G; Gao H; Windahl SH; Humire P; Ohlsson C; Berggren PO; Gustafsson JA; Dahlman-Wright K. 2014. aP2-Cre-mediated inactivation of estrogen receptor alpha causes hydrometra. PLoS One 9(1):e85581. [PubMed: 24416430]  [MGI Ref ID J:211941]

Barak Y; Liao D; He W; Ong ES; Nelson MC; Olefsky JM; Boland R; Evans RM. 2002. Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer. Proc Natl Acad Sci U S A 99(1):303-8. [PubMed: 11756685]  [MGI Ref ID J:73557]

Batifoulier-Yiannikouris F; Karounos M; Charnigo R; English VL; Rateri DL; Daugherty A; Cassis LA. 2011. Adipocyte-specific deficiency of angiotensinogen decreases plasma angiotensinogen concentration and systolic blood pressure in mice. Am J Physiol Regul Integr Comp Physiol :. [PubMed: 22071160]  [MGI Ref ID J:178836]

Cernkovich ER; Deng J; Bond MC; Combs TP; Harp JB. 2008. Adipose-specific disruption of signal transducer and activator of transcription 3 increases body weight and adiposity. Endocrinology 149(4):1581-90. [PubMed: 18096662]  [MGI Ref ID J:136030]

Chalkiadaki A; Guarente L. 2012. High-Fat Diet Triggers Inflammation-Induced Cleavage of SIRT1 in Adipose Tissue To Promote Metabolic Dysfunction. Cell Metab 16(2):180-8. [PubMed: 22883230]  [MGI Ref ID J:187379]

Chung S; Sawyer JK; Gebre AK; Maeda N; Parks JS. 2011. Adipose tissue ATP binding cassette transporter A1 contributes to high-density lipoprotein biogenesis in vivo. Circulation 124(15):1663-72. [PubMed: 21931081]  [MGI Ref ID J:189483]

Cybulski N; Polak P; Auwerx J; Ruegg MA; Hall MN. 2009. mTOR complex 2 in adipose tissue negatively controls whole-body growth. Proc Natl Acad Sci U S A 106(24):9902-7. [PubMed: 19497867]  [MGI Ref ID J:150064]

Dib L; Bugge A; Collins S. 2014. LXRalpha fuels fatty acid-stimulated oxygen consumption in white adipocytes. J Lipid Res 55(2):247-57. [PubMed: 24259533]  [MGI Ref ID J:208190]

Ding X; Boney-Montoya J; Owen BM; Bookout AL; Coate KC; Mangelsdorf DJ; Kliewer SA. 2012. betaKlotho is required for fibroblast growth factor 21 effects on growth and metabolism. Cell Metab 16(3):387-93. [PubMed: 22958921]  [MGI Ref ID J:189018]

Dusaulcy R; Rancoule C; Gres S; Wanecq E; Colom A; Guigne C; van Meeteren LA; Moolenaar WH; Valet P; Saulnier-Blache JS. 2011. Adipose-specific disruption of autotaxin enhances nutritional fattening and reduces plasma lysophosphatidic acid. J Lipid Res 52(6):1247-55. [PubMed: 21421848]  [MGI Ref ID J:173584]

Ellis JM; Li LO; Wu PC; Koves TR; Ilkayeva O; Stevens RD; Watkins SM; Muoio DM; Coleman RA. 2010. Adipose acyl-CoA synthetase-1 directs fatty acids toward beta-oxidation and is required for cold thermogenesis. Cell Metab 12(1):53-64. [PubMed: 20620995]  [MGI Ref ID J:162996]

Enguix N; Pardo R; Gonzalez A; Lopez VM; Simo R; Kralli A; Villena JA. 2013. Mice lacking PGC-1beta in adipose tissues reveal a dissociation between mitochondrial dysfunction and insulin resistance. Mol Metab 2(3):215-26. [PubMed: 24049736]  [MGI Ref ID J:221221]

Frost RJ; Olson EN. 2011. Control of glucose homeostasis and insulin sensitivity by the Let-7 family of microRNAs. Proc Natl Acad Sci U S A 108(52):21075-80. [PubMed: 22160727]  [MGI Ref ID J:180138]

Gabrielsen JS; Gao Y; Simcox JA; Huang J; Thorup D; Jones D; Cooksey RC; Gabrielsen D; Adams TD; Hunt SC; Hopkins PN; Cefalu WT; McClain DA. 2012. Adipocyte iron regulates adiponectin and insulin sensitivity. J Clin Invest 122(10):3529-40. [PubMed: 22996660]  [MGI Ref ID J:191755]

Garcia-Alonso V; Lopez-Vicario C; Titos E; Moran-Salvador E; Gonzalez-Periz A; Rius B; Parrizas M; Werz O; Arroyo V; Claria J. 2013. Coordinate functional regulation between microsomal prostaglandin E synthase-1 (mPGES-1) and peroxisome proliferator-activated receptor gamma (PPARgamma) in the conversion of white-to-brown adipocytes. J Biol Chem 288(39):28230-42. [PubMed: 23943621]  [MGI Ref ID J:203851]

Garcia-Arcos I; Hiyama Y; Drosatos K; Bharadwaj KG; Hu Y; Son NH; O'Byrne SM; Chang CL; Deckelbaum RJ; Takahashi M; Westerterp M; Obunike JC; Jiang H; Yagyu H; Blaner WS; Goldberg IJ. 2013. Adipose-specific lipoprotein lipase deficiency more profoundly affects brown than white fat biology. J Biol Chem 288(20):14046-58. [PubMed: 23542081]  [MGI Ref ID J:198590]

Genetic Resource Science at The Jackson Laboratory. 2008. Expression/Specificity Patterns of Cre Alleles Direct Data Submission from Genetic Resource Science :.  [MGI Ref ID J:137887]

Genetic Resource Science at The Jackson Laboratory. 2012. Expression/Specificity Patterns of Cre Alleles, 2011 Direct Data Submission from Genetic Resource Science :.  [MGI Ref ID J:184578]

He Z; Zhu HH; Bauler TJ; Wang J; Ciaraldi T; Alderson N; Li S; Raquil MA; Ji K; Wang S; Shao J; Henry RR; King PD; Feng GS. 2013. Nonreceptor tyrosine phosphatase Shp2 promotes adipogenesis through inhibition of p38 MAP kinase. Proc Natl Acad Sci U S A 110(1):E79-88. [PubMed: 23236157]  [MGI Ref ID J:192542]

Hesse D; Hommel A; Jaschke A; Moser M; Bernhardt U; Zahn C; Kluge R; Wittschen P; Gruber AD; Al-Hasani H; Joost HG; Schurmann A. 2010. Altered GLUT4 trafficking in adipocytes in the absence of the GTPase Arfrp1. Biochem Biophys Res Commun 394(4):896-903. [PubMed: 20230794]  [MGI Ref ID J:159231]

Hofmann SM; Zhou L; Perez-Tilve D; Greer T; Grant E; Wancata L; Thomas A; Pfluger PT; Basford JE; Gilham D; Herz J; Tschop MH; Hui DY. 2007. Adipocyte LDL receptor-related protein-1 expression modulates postprandial lipid transport and glucose homeostasis in mice. J Clin Invest 117(11):3271-82. [PubMed: 17948131]  [MGI Ref ID J:127398]

Hommel A; Hesse D; Volker W; Jaschke A; Moser M; Engel T; Bluher M; Zahn C; Chadt A; Ruschke K; Vogel H; Kluge R; Robenek H; Joost HG; Schurmann A. 2010. The ARF-like GTPase ARFRP1 is essential for lipid droplet growth and is involved in the regulation of lipolysis. Mol Cell Biol 30(5):1231-42. [PubMed: 20038528]  [MGI Ref ID J:161742]

Jiang M; Gao M; Wu C; He H; Guo X; Zhou Z; Yang H; Xiao X; Liu G; Sha J. 2014. Lack of testicular seipin causes teratozoospermia syndrome in men. Proc Natl Acad Sci U S A 111(19):7054-9. [PubMed: 24778225]  [MGI Ref ID J:211072]

Johnson AL; Zinser GM; Waltz SE. 2014. Loss of vitamin D receptor signaling from the mammary epithelium or adipose tissue alters pubertal glandular development. Am J Physiol Endocrinol Metab 307(8):E674-85. [PubMed: 25139050]  [MGI Ref ID J:215564]

Jonker JW; Suh JM; Atkins AR; Ahmadian M; Li P; Whyte J; He M; Juguilon H; Yin YQ; Phillips CT; Yu RT; Olefsky JM; Henry RR; Downes M; Evans RM. 2012. A PPARgamma-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis. Nature 485(7398):391-4. [PubMed: 22522926]  [MGI Ref ID J:183996]

Kihira Y; Miyake M; Hirata M; Hoshina Y; Kato K; Shirakawa H; Sakaue H; Yamano N; Izawa-Ishizawa Y; Ishizawa K; Ikeda Y; Tsuchiya K; Tamaki T; Tomita S. 2014. Deletion of hypoxia-inducible factor-1alpha in adipocytes enhances glucagon-like peptide-1 secretion and reduces adipose tissue inflammation. PLoS One 9(4):e93856. [PubMed: 24705496]  [MGI Ref ID J:215021]

Kilcoyne KR; Smith LB; Atanassova N; Macpherson S; McKinnell C; van den Driesche S; Jobling MS; Chambers TJ; De Gendt K; Verhoeven G; O'Hara L; Platts S; Renato de Franca L; Lara NL; Anderson RA; Sharpe RM. 2014. Fetal programming of adult Leydig cell function by androgenic effects on stem/progenitor cells. Proc Natl Acad Sci U S A 111(18):E1924-32. [PubMed: 24753613]  [MGI Ref ID J:211084]

Kumar A; Lawrence JC Jr; Jung DY; Ko HJ; Keller SR; Kim JK; Magnuson MA; Harris TE. 2010. Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism. Diabetes 59(6):1397-406. [PubMed: 20332342]  [MGI Ref ID J:169357]

Lee YS; Kim JW; Osborne O; Oh da Y; Sasik R; Schenk S; Chen A; Chung H; Murphy A; Watkins SM; Quehenberger O; Johnson RS; Olefsky JM. 2014. Increased adipocyte O2 consumption triggers HIF-1alpha, causing inflammation and insulin resistance in obesity. Cell 157(6):1339-52. [PubMed: 24906151]  [MGI Ref ID J:214449]

Lenz LS; Marx J; Chamulitrat W; Kaiser I; Grone HJ; Liebisch G; Schmitz G; Elsing C; Straub BK; Fullekrug J; Stremmel W; Herrmann T. 2011. Adipocyte-specific inactivation of Acyl-CoA synthetase fatty acid transport protein 4 (Fatp4) in mice causes adipose hypertrophy and alterations in metabolism of complex lipids under high fat diet. J Biol Chem 286(41):35578-87. [PubMed: 21808061]  [MGI Ref ID J:177596]

Li P; Fan W; Xu J; Lu M; Yamamoto H; Auwerx J; Sears DD; Talukdar S; Oh D; Chen A; Bandyopadhyay G; Scadeng M; Ofrecio JM; Nalbandian S; Olefsky JM. 2011. Adipocyte NCoR knockout decreases PPARgamma phosphorylation and enhances PPARgamma activity and insulin sensitivity. Cell 147(4):815-26. [PubMed: 22078880]  [MGI Ref ID J:178828]

Li X; Bartke A; Berryman DE; Funk K; Kopchick JJ; List EO; Sun L; Miller RA. 2013. Direct and indirect effects of growth hormone receptor ablation on liver expression of xenobiotic metabolizing genes. Am J Physiol Endocrinol Metab 305(8):E942-50. [PubMed: 23941873]  [MGI Ref ID J:203856]

List EO; Berryman DE; Funk K; Gosney ES; Jara A; Kelder B; Wang X; Kutz L; Troike K; Lozier N; Mikula V; Lubbers ER; Zhang H; Vesel C; Junnila RK; Frank SJ; Masternak MM; Bartke A; Kopchick JJ. 2013. The role of GH in adipose tissue: lessons from adipose-specific GH receptor gene-disrupted mice. Mol Endocrinol 27(3):524-35. [PubMed: 23349524]  [MGI Ref ID J:206358]

Liu M; Bai J; He S; Villarreal R; Hu D; Zhang C; Yang X; Liang H; Slaga TJ; Yu Y; Zhou Z; Blenis J; Scherer PE; Dong LQ; Liu F. 2014. Grb10 promotes lipolysis and thermogenesis by phosphorylation-dependent feedback inhibition of mTORC1. Cell Metab 19(6):967-80. [PubMed: 24746805]  [MGI Ref ID J:213603]

Liu W; Bi P; Shan T; Yang X; Yin H; Wang YX; Liu N; Rudnicki MA; Kuang S. 2013. miR-133a Regulates Adipocyte Browning In Vivo. PLoS Genet 9(7):e1003626. [PubMed: 23874225]  [MGI Ref ID J:199296]

Luk CT; Shi SY; Choi D; Cai EP; Schroer SA; Woo M. 2013. In vivo knockdown of adipocyte erythropoietin receptor does not alter glucose or energy homeostasis. Endocrinology 154(10):3652-9. [PubMed: 23885016]  [MGI Ref ID J:203289]

Luo W; Cao J; Li J; He W. 2008. Adipose tissue-specific PPARgamma deficiency increases resistance to oxidative stress. Exp Gerontol 43(3):154-63. [PubMed: 18083318]  [MGI Ref ID J:132506]

Mao J; Yang T; Gu Z; Heird WC; Finegold MJ; Lee B; Wakil SJ. 2009. aP2-Cre-mediated inactivation of acetyl-CoA carboxylase 1 causes growth retardation and reduced lipid accumulation in adipose tissues. Proc Natl Acad Sci U S A 106(41):17576-81. [PubMed: 19805143]  [MGI Ref ID J:153681]

Martens K; Bottelbergs A; Baes M. 2010. Ectopic recombination in the central and peripheral nervous system by aP2/FABP4-Cre mice: implications for metabolism research. FEBS Lett 584(5):1054-8. [PubMed: 20138876]  [MGI Ref ID J:157524]

Martens K; Bottelbergs A; Peeters A; Jacobs F; Espeel M; Carmeliet P; Van Veldhoven PP; Baes M. 2012. Peroxisome deficient aP2-Pex5 knockout mice display impaired white adipocyte and muscle function concomitant with reduced adrenergic tone. Mol Genet Metab 107(4):735-47. [PubMed: 23141464]  [MGI Ref ID J:190874]

McInnes KJ; Smith LB; Hunger NI; Saunders PT; Andrew R; Walker BR. 2012. Deletion of the androgen receptor in adipose tissue in male mice elevates retinol binding protein 4 and reveals independent effects on visceral fat mass and on glucose homeostasis. Diabetes 61(5):1072-81. [PubMed: 22415878]  [MGI Ref ID J:196857]

Minamino T; Orimo M; Shimizu I; Kunieda T; Yokoyama M; Ito T; Nojima A; Nabetani A; Oike Y; Matsubara H; Ishikawa F; Komuro I. 2009. A crucial role for adipose tissue p53 in the regulation of insulin resistance. Nat Med 15(9):1082-7. [PubMed: 19718037]  [MGI Ref ID J:154323]

Miranda DA; Kim JH; Nguyen LN; Cheng W; Tan BC; Goh VJ; Tan JS; Yaligar J; Kn BP; Velan SS; Wang H; Silver DL. 2014. Fat storage-inducing transmembrane protein 2 is required for normal fat storage in adipose tissue. J Biol Chem 289(14):9560-72. [PubMed: 24519944]  [MGI Ref ID J:212437]

Muller TD; Lee SJ; Jastroch M; Kabra D; Stemmer K; Aichler M; Abplanalp B; Ananthakrishnan G; Bhardwaj N; Collins S; Divanovic S; Endele M; Finan B; Gao Y; Habegger KM; Hembree J; Heppner KM; Hofmann S; Holland J; Kuchler D; Kutschke M; Krishna R; Lehti M; Oelkrug R; Ottaway N; Perez-Tilve D; Raver C; Walch AK; Schriever SC; Speakman J; Tseng YH; Diaz-Meco M; Pfluger PT; Moscat J; Tschop MH. 2013. p62 links beta-adrenergic input to mitochondrial function and thermogenesis. J Clin Invest 123(1):469-78. [PubMed: 23257354]  [MGI Ref ID J:194291]

Mullican SE; Tomaru T; Gaddis CA; Peed LC; Sundaram A; Lazar MA. 2013. A novel adipose-specific gene deletion model demonstrates potential pitfalls of existing methods. Mol Endocrinol 27(1):127-34. [PubMed: 23192980]  [MGI Ref ID J:199860]

Nadra K; Medard JJ; Mul JD; Han GS; Gres S; Pende M; Metzger D; Chambon P; Cuppen E; Saulnier-Blache JS; Carman GM; Desvergne B; Chrast R. 2012. Cell autonomous lipin 1 function is essential for development and maintenance of white and brown adipose tissue. Mol Cell Biol 32(23):4794-810. [PubMed: 23028044]  [MGI Ref ID J:192733]

Nadra K; Medard JJ; Quignodon L; Verheijen MH; Desvergne B; Chrast R. 2012. Epineurial adipocytes are dispensable for Schwann cell myelination. J Neurochem 123(5):662-7. [PubMed: 22849425]  [MGI Ref ID J:190578]

Nosavanh L; Yu DH; Jaehnig EJ; Tong Q; Shen L; Chen MH. 2015. Cell-autonomous activation of Hedgehog signaling inhibits brown adipose tissue development. Proc Natl Acad Sci U S A 112(16):5069-74. [PubMed: 25848030]  [MGI Ref ID J:220963]

O'Hara L; McInnes K; Simitsidellis I; Morgan S; Atanassova N; Slowikowska-Hilczer J; Kula K; Szarras-Czapnik M; Milne L; Mitchell RT; Smith LB. 2015. Autocrine androgen action is essential for Leydig cell maturation and function, and protects against late-onset Leydig cell apoptosis in both mice and men. FASEB J 29(3):894-910. [PubMed: 25404712]  [MGI Ref ID J:219646]

Pan D; Fujimoto M; Lopes A; Wang YX. 2009. Twist-1 is a PPARdelta-inducible, negative-feedback regulator of PGC-1alpha in brown fat metabolism. Cell 137(1):73-86. [PubMed: 19345188]  [MGI Ref ID J:147973]

Pardo R; Enguix N; Lasheras J; Feliu JE; Kralli A; Villena JA. 2011. Rosiglitazone-induced mitochondrial biogenesis in white adipose tissue is independent of peroxisome proliferator-activated receptor gamma coactivator-1alpha. PLoS One 6(11):e26989. [PubMed: 22087241]  [MGI Ref ID J:180984]

Paschos GK; Ibrahim S; Song WL; Kunieda T; Grant G; Reyes TM; Bradfield CA; Vaughan CH; Eiden M; Masoodi M; Griffin JL; Wang F; Lawson JA; Fitzgerald GA. 2012. Obesity in mice with adipocyte-specific deletion of clock component Arntl. Nat Med 18(12):1768-77. [PubMed: 23142819]  [MGI Ref ID J:190442]

Perry RJ; Camporez JP; Kursawe R; Titchenell PM; Zhang D; Perry CJ; Jurczak MJ; Abudukadier A; Han MS; Zhang XM; Ruan HB; Yang X; Caprio S; Kaech SM; Sul HS; Birnbaum MJ; Davis RJ; Cline GW; Petersen KF; Shulman GI. 2015. Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes. Cell 160(4):745-58. [PubMed: 25662011]  [MGI Ref ID J:219885]

Peschard P; McCarthy A; Leblanc-Dominguez V; Yeo M; Guichard S; Stamp G; Marshall CJ. 2012. Genetic deletion of RALA and RALB small GTPases reveals redundant functions in development and tumorigenesis. Curr Biol 22(21):2063-8. [PubMed: 23063435]  [MGI Ref ID J:199742]

Polak P; Cybulski N; Feige JN; Auwerx J; Ruegg MA; Hall MN. 2008. Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration. Cell Metab 8(5):399-410. [PubMed: 19046571]  [MGI Ref ID J:143749]

Pospisilik JA; Schramek D; Schnidar H; Cronin SJ; Nehme NT; Zhang X; Knauf C; Cani PD; Aumayr K; Todoric J; Bayer M; Haschemi A; Puviindran V; Tar K; Orthofer M; Neely GG; Dietzl G; Manoukian A; Funovics M; Prager G; Wagner O; Ferrandon D; Aberger F; HuiCC; Esterbauer H; Penninger JM. 2010. Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. Cell 140(1):148-60. [PubMed: 20074523]  [MGI Ref ID J:166285]

Putnam K; Batifoulier-Yiannikouris F; Bharadwaj KG; Lewis E; Karounos M; Daugherty A; Cassis LA. 2012. Deficiency of angiotensin type 1a receptors in adipocytes reduces differentiation and promotes hypertrophy of adipocytes in lean mice. Endocrinology 153(10):4677-86. [PubMed: 22919058]  [MGI Ref ID J:192945]

Qian SW; Tang Y; Li X; Liu Y; Zhang YY; Huang HY; Xue RD; Yu HY; Guo L; Gao HD; Liu Y; Sun X; Li YM; Jia WP; Tang QQ. 2013. BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis. Proc Natl Acad Sci U S A 110(9):E798-807. [PubMed: 23388637]  [MGI Ref ID J:195212]

Rohm M; Sommerfeld A; Strzoda D; Jones A; Sijmonsma TP; Rudofsky G; Wolfrum C; Sticht C; Gretz N; Zeyda M; Leitner L; Nawroth PP; Stulnig TM; Diaz MB; Vegiopoulos A; Herzig S. 2013. Transcriptional cofactor TBLR1 controls lipid mobilization in white adipose tissue. Cell Metab 17(4):575-85. [PubMed: 23499424]  [MGI Ref ID J:198124]

Ryu MJ; Kim SJ; Kim YK; Choi MJ; Tadi S; Lee MH; Lee SE; Chung HK; Jung SB; Kim HJ; Jo YS; Kim KS; Lee SH; Kim JM; Kweon GR; Park KC; Lee JU; Kong YY; Lee CH; Chung J; Shong M. 2013. Crif1 deficiency reduces adipose OXPHOS capacity and triggers inflammation and insulin resistance in mice. PLoS Genet 9(3):e1003356. [PubMed: 23516375]  [MGI Ref ID J:195282]

Sabio G; Das M; Mora A; Zhang Z; Jun JY; Ko HJ; Barrett T; Kim JK; Davis RJ. 2008. A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science 322(5907):1539-43. [PubMed: 19056984]  [MGI Ref ID J:142035]

Shi SY; Luk CT; Brunt JJ; Sivasubramaniyam T; Lu SY; Schroer SA; Woo M. 2014. Adipocyte-specific deficiency of Janus kinase (JAK) 2 in mice impairs lipolysis and increases body weight, and leads to insulin resistance with ageing. Diabetologia 57(5):1016-26. [PubMed: 24531222]  [MGI Ref ID J:210481]

Shimizu I; Aprahamian T; Kikuchi R; Shimizu A; Papanicolaou KN; MacLauchlan S; Maruyama S; Walsh K. 2014. Vascular rarefaction mediates whitening of brown fat in obesity. J Clin Invest 124(5):2099-112. [PubMed: 24713652]  [MGI Ref ID J:212765]

Shimizu I; Yoshida Y; Katsuno T; Tateno K; Okada S; Moriya J; Yokoyama M; Nojima A; Ito T; Zechner R; Komuro I; Kobayashi Y; Minamino T. 2012. p53-induced adipose tissue inflammation is critically involved in the development of insulin resistance in heart failure. Cell Metab 15(1):51-64. [PubMed: 22225876]  [MGI Ref ID J:182322]

Shimizu I; Yoshida Y; Moriya J; Nojima A; Uemura A; Kobayashi Y; Minamino T. 2013. Semaphorin3E-induced inflammation contributes to insulin resistance in dietary obesity. Cell Metab 18(4):491-504. [PubMed: 24093674]  [MGI Ref ID J:206006]

Singh R; Xiang Y; Wang Y; Baikati K; Cuervo AM; Luu YK; Tang Y; Pessin JE; Schwartz GJ; Czaja MJ. 2009. Autophagy regulates adipose mass and differentiation in mice. J Clin Invest 119(11):3329-39. [PubMed: 19855132]  [MGI Ref ID J:154591]

Starkey JD; Yamamoto M; Yamamoto S; Goldhamer DJ. 2011. Skeletal muscle satellite cells are committed to myogenesis and do not spontaneously adopt nonmyogenic fates. J Histochem Cytochem 59(1):33-46. [PubMed: 21339173]  [MGI Ref ID J:169754]

Suh JM; Jonker JW; Ahmadian M; Goetz R; Lackey D; Osborn O; Huang Z; Liu W; Yoshihara E; van Dijk TH; Havinga R; Fan W; Yin YQ; Yu RT; Liddle C; Atkins AR; Olefsky JM; Mohammadi M; Downes M; Evans RM. 2014. Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer. Nature 513(7518):436-9. [PubMed: 25043058]  [MGI Ref ID J:217106]

Sumara G; Sumara O; Kim JK; Karsenty G. 2012. Gut-derived serotonin is a multifunctional determinant to fasting adaptation. Cell Metab 16(5):588-600. [PubMed: 23085101]  [MGI Ref ID J:190895]

Sung HK; Doh KO; Son JE; Park JG; Bae Y; Choi S; Nelson SM; Cowling R; Nagy K; Michael IP; Koh GY; Adamson SL; Pawson T; Nagy A. 2013. Adipose vascular endothelial growth factor regulates metabolic homeostasis through angiogenesis. Cell Metab 17(1):61-72. [PubMed: 23312284]  [MGI Ref ID J:195071]

Terrand J; Bruban V; Zhou L; Gong W; El Asmar Z; May P; Zurhove K; Haffner P; Philippe C; Woldt E; Matz RL; Gracia C; Metzger D; Auwerx J; Herz J; Boucher P. 2009. LRP1 controls intracellular cholesterol storage and fatty acid synthesis through modulation of Wnt signaling. J Biol Chem 284(1):381-8. [PubMed: 18990694]  [MGI Ref ID J:146007]

Tian X; Hu T; Zhang H; He L; Huang X; Liu Q; Yu W; He L; Yang Z; Yan Y; Yang X; Zhong TP; Pu WT; Zhou B. 2014. Vessel formation. De novo formation of a distinct coronary vascular population in neonatal heart. Science 345(6192):90-4. [PubMed: 24994653]  [MGI Ref ID J:212075]

Urs S; Harrington A; Liaw L; Small D. 2006. Selective expression of an aP2/Fatty Acid Binding Protein 4-Cre transgene in non-adipogenic tissues during embryonic development. Transgenic Res 15(5):647-53. [PubMed: 16952017]  [MGI Ref ID J:114599]

Urs S; Venkatesh D; Tang Y; Henderson T; Yang X; Friesel RE; Rosen CJ; Liaw L. 2010. Sprouty1 is a critical regulatory switch of mesenchymal stem cell lineage allocation. FASEB J 24(9):3264-73. [PubMed: 20410440]  [MGI Ref ID J:163565]

Wang L; Xu S; Lee JE; Baldridge A; Grullon S; Peng W; Ge K. 2013. Histone H3K9 methyltransferase G9a represses PPARgamma expression and adipogenesis. EMBO J 32(1):45-59. [PubMed: 23178591]  [MGI Ref ID J:192309]

Wang ZV; Deng Y; Wang QA; Sun K; Scherer PE. 2010. Identification and characterization of a promoter cassette conferring adipocyte-specific gene expression. Endocrinology 151(6):2933-9. [PubMed: 20363877]  [MGI Ref ID J:160881]

Wiedemann MS; Wueest S; Item F; Schoenle EJ; Konrad D. 2013. Adipose tissue inflammation contributes to short-term high-fat diet-induced hepatic insulin resistance. Am J Physiol Endocrinol Metab 305(3):E388-95. [PubMed: 23736545]  [MGI Ref ID J:203208]

Wu JW; Wang SP; Casavant S; Moreau A; Yang GS; Mitchell GA. 2012. Fasting energy homeostasis in mice with adipose deficiency of desnutrin/adipose triglyceride lipase. Endocrinology 153(5):2198-207. [PubMed: 22374972]  [MGI Ref ID J:185000]

Wueest S; Rapold RA; Schoenle EJ; Konrad D. 2010. Fas activation in adipocytes impairs insulin-stimulated glucose uptake by reducing Akt. FEBS Lett 584(19):4187-92. [PubMed: 20828573]  [MGI Ref ID J:164421]

Wueest S; Rapold RA; Schumann DM; Rytka JM; Schildknecht A; Nov O; Chervonsky AV; Rudich A; Schoenle EJ; Donath MY; Konrad D. 2010. Deletion of Fas in adipocytes relieves adipose tissue inflammation and hepatic manifestations of obesity in mice. J Clin Invest 120(1):191-202. [PubMed: 19955656]  [MGI Ref ID J:156776]

Xue P; Hou Y; Chen Y; Yang B; Fu J; Zheng H; Yarborough K; Woods CG; Liu D; Yamamoto M; Zhang Q; Andersen ME; Pi J. 2013. Adipose deficiency of Nrf2 in ob/ob mice results in severe metabolic syndrome. Diabetes 62(3):845-54. [PubMed: 23238296]  [MGI Ref ID J:208590]

Yang C; Jin C; Li X; Wang F; McKeehan WL; Luo Y. 2012. Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB. PLoS One 7(3):e33870. [PubMed: 22442730]  [MGI Ref ID J:187036]

Yao L; Heuser-Baker J; Herlea-Pana O; Zhang N; Szweda LI; Griffin TM; Barlic-Dicen J. 2014. Deficiency in adipocyte chemokine receptor CXCR4 exacerbates obesity and compromises thermoregulatory responses of brown adipose tissue in a mouse model of diet-induced obesity. FASEB J 28(10):4534-50. [PubMed: 25016030]  [MGI Ref ID J:217569]

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Zheng R; Yang L; Sikorski MA; Enns LC; Czyzyk TA; Ladiges WC; McKnight GS. 2013. Deficiency of the RIIbeta subunit of PKA affects locomotor activity and energy homeostasis in distinct neuronal populations. Proc Natl Acad Sci U S A 110(17):E1631-40. [PubMed: 23569242]  [MGI Ref ID J:196157]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX11

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, hemizygous mice are bred to wildtype (noncarrier) mice from the colony or to C57BL/6J inbred mice (Stock No. 000664).
Mating SystemInbred x Hemizygote         (Female x Male)   01-MAR-06
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $239.00Female or MaleHemizygous for Tg(Fabp4-cre)1Rev  
Price per Pair (US dollars $)Pair Genotype
$313.00Hemizygous for Tg(Fabp4-cre)1Rev x Noncarrier  
$313.00Noncarrier x Hemizygous for Tg(Fabp4-cre)1Rev  
$478.00Hemizygous for Tg(Fabp4-cre)1Rev x Hemizygous for Tg(Fabp4-cre)1Rev  

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $310.70Female or MaleHemizygous for Tg(Fabp4-cre)1Rev  
Price per Pair (US dollars $)Pair Genotype
$406.90Hemizygous for Tg(Fabp4-cre)1Rev x Noncarrier  
$406.90Noncarrier x Hemizygous for Tg(Fabp4-cre)1Rev  
$621.40Hemizygous for Tg(Fabp4-cre)1Rev x Hemizygous for Tg(Fabp4-cre)1Rev  

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.

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Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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Terms of Use

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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty


In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.