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| Cre recombinase expression in these mice is detected in brown and white gonadal and subcutaneous adipose tissue. When crossed with a strain containing a loxP site flanked sequence of interest, Cre-mediated recombination results in deletion of the targeted gene specifically in adipose tissue. This strain represents an effective tool for generating tissue-specific targeted mutants. | |||||||||||||||||||
- Description
- Disease & phenotype
- Genes & alleles
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- References
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Description
Strain Information
Type Congenic; Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Inbred x Hemizygote (Female x Male) 01-MAR-06 Species laboratory mouse Generation N9+N17 (21-APR-11)
Generation DefinitionsDonating Investigator Ronald M. Evans, The Salk Inst for Biological Studies Description
These transgenic mice express Cre recombinase under the control of the mouse Fabp4, fatty acid binding protein 4, adipocyte, promoter. Cre recombinase expression is detected in brown and white gonadal and subcutaneous adipose tissue. No expression is detected in skeletal muscle. When crossed with a strain containing a loxP site flanked sequence of interest, Cre-mediated recombination results in deletion of the targeted gene specifically in adipose tissue. Mice that are homozygous for the targeted mutation are viable. This strain represents an effective tool for generating tissue-specific targeted mutants.View cre expression characterization.
Development
A transgenic construct containing cre coding sequence under the control of the 5.4 kb Fabp4, fatty acid binding protein 4, adipocyte, promoter was introduced into unknown outbred donor eggs. The resulting male transgenic mice were crossed to B6.129-Ppargtm2Rev/J (Stock No. 004584) mice and subsequently crossed to C57BL/6J mice for 9 generations in the laboratory of Dr. Yaacov Barak at The Jackson Laboratory. The Ppargtm2Rev/J allele was bred out of the strain during the backcrossing to C57BL/6J.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of Fabp4
017560 B6.FVB-Tg(Fabp4-IKBKB*)49Hxu/J 018625 B6.FVB-Tg(Fabp4-lacZ)4Mosh/J 003393 B6;SJL-Tg(aP2-SREBF1c)9884Reh/J 017321 C57BL/6-Tg(Fabp4-Dgat1)2Far/J View Strains carrying other alleles of Fabp4 (4 strains)
Additional Web Information
Introduction to Cre-lox technology
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
cre relatedResearch Tools
Cre-lox System
Cre Recombinase Expression
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Research Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Tg(Fabp4-cre)1Rev | ||
|---|---|---|---|
| Allele Name | transgene insertion 1, Ronald M Evans | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) | FABP4-Cre; aP2-CRE; | ||
| Mutation Made By | Weiman He, Texas A&M University | ||
| Site of Expression | adipose tissue | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Promoter | Fabp4, fatty acid binding protein 4, adipocyte, mouse, laboratory | ||
| Gene Symbol and Name | Tg(Fabp4-cre)1Rev, transgene insertion 1, Ronald M Evans | ||
| Chromosome | UN | ||
| Gene Common Name(s) | aP2-CRE; | ||
| Driver Note | Fabp4 | ||
| Molecular Note | Sequence encoding cre recombinase was adjoined to the Fabp4 promoter, which is active in white and brown adipose tissue. Northern blot analysis and a functional assay showed the transgene to be abundantly expressed in brown and white adipose tissue. Significant expression was not detected in other tissues including skeletal muscle, liver, and heart. [MGI Ref ID J:73557] [MGI Ref ID J:88210] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Generic Cre Melt Curve Analysis, Melt Curve Analysis
Generic Cre, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
He W; Barak Y; Hevener A; Olson P; Liao D; Le J; Nelson M; Ong E; Olefsky JM; Evans RM. 2003. Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle. Proc Natl Acad Sci U S A 100(26):15712-7. [PubMed: 14660788] [MGI Ref ID J:88210]
Additional References
Tg(Fabp4-cre)1Rev relatedAhmadian M; Abbott MJ; Tang T; Hudak CS; Kim Y; Bruss M; Hellerstein MK; Lee HY; Samuel VT; Shulman GI; Wang Y; Duncan RE; Kang C; Sul HS. 2011. Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype. Cell Metab 13(6):739-48. [PubMed: 21641555] [MGI Ref ID J:176083]
Barak Y; Liao D; He W; Ong ES; Nelson MC; Olefsky JM; Boland R; Evans RM. 2002. Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer. Proc Natl Acad Sci U S A 99(1):303-8. [PubMed: 11756685] [MGI Ref ID J:73557]
Batifoulier-Yiannikouris F; Karounos M; Charnigo R; English VL; Rateri DL; Daugherty A; Cassis LA. 2011. Adipocyte-specific deficiency of angiotensinogen decreases plasma angiotensinogen concentration and systolic blood pressure in mice. Am J Physiol Regul Integr Comp Physiol :. [PubMed: 22071160] [MGI Ref ID J:178836]
Cernkovich ER; Deng J; Bond MC; Combs TP; Harp JB. 2008. Adipose-specific disruption of signal transducer and activator of transcription 3 increases body weight and adiposity. Endocrinology 149(4):1581-90. [PubMed: 18096662] [MGI Ref ID J:136030]
Chalkiadaki A; Guarente L. 2012. High-Fat Diet Triggers Inflammation-Induced Cleavage of SIRT1 in Adipose Tissue To Promote Metabolic Dysfunction. Cell Metab 16(2):180-8. [PubMed: 22883230] [MGI Ref ID J:187379]
Chung S; Sawyer JK; Gebre AK; Maeda N; Parks JS. 2011. Adipose tissue ATP binding cassette transporter A1 contributes to high-density lipoprotein biogenesis in vivo. Circulation 124(15):1663-72. [PubMed: 21931081] [MGI Ref ID J:189483]
Cybulski N; Polak P; Auwerx J; Ruegg MA; Hall MN. 2009. mTOR complex 2 in adipose tissue negatively controls whole-body growth. Proc Natl Acad Sci U S A 106(24):9902-7. [PubMed: 19497867] [MGI Ref ID J:150064]
Ding X; Boney-Montoya J; Owen BM; Bookout AL; Coate KC; Mangelsdorf DJ; Kliewer SA. 2012. betaKlotho is required for fibroblast growth factor 21 effects on growth and metabolism. Cell Metab 16(3):387-93. [PubMed: 22958921] [MGI Ref ID J:189018]
Dusaulcy R; Rancoule C; Gres S; Wanecq E; Colom A; Guigne C; van Meeteren LA; Moolenaar WH; Valet P; Saulnier-Blache JS. 2011. Adipose-specific disruption of autotaxin enhances nutritional fattening and reduces plasma lysophosphatidic acid. J Lipid Res 52(6):1247-55. [PubMed: 21421848] [MGI Ref ID J:173584]
Ellis JM; Li LO; Wu PC; Koves TR; Ilkayeva O; Stevens RD; Watkins SM; Muoio DM; Coleman RA. 2010. Adipose acyl-CoA synthetase-1 directs fatty acids toward beta-oxidation and is required for cold thermogenesis. Cell Metab 12(1):53-64. [PubMed: 20620995] [MGI Ref ID J:162996]
Frost RJ; Olson EN. 2011. Control of glucose homeostasis and insulin sensitivity by the Let-7 family of microRNAs. Proc Natl Acad Sci U S A 108(52):21075-80. [PubMed: 22160727] [MGI Ref ID J:180138]
Gabrielsen JS; Gao Y; Simcox JA; Huang J; Thorup D; Jones D; Cooksey RC; Gabrielsen D; Adams TD; Hunt SC; Hopkins PN; Cefalu WT; McClain DA. 2012. Adipocyte iron regulates adiponectin and insulin sensitivity. J Clin Invest 122(10):3529-40. [PubMed: 22996660] [MGI Ref ID J:191755]
Genetic Resource Sciences at The Jackson Laboratory. 2012. Expression/Specificity Patterns of Cre Alleles, 2011 MGI Direct Data Submission :. [MGI Ref ID J:184578]
Genetic Resource Sciences at The Jackson Laboratory. 2008. Expression/Specificity patterns of Cre transgenes MGI Direct Data Submission :. [MGI Ref ID J:137887]
He Z; Zhu HH; Bauler TJ; Wang J; Ciaraldi T; Alderson N; Li S; Raquil MA; Ji K; Wang S; Shao J; Henry RR; King PD; Feng GS. 2013. Nonreceptor tyrosine phosphatase Shp2 promotes adipogenesis through inhibition of p38 MAP kinase. Proc Natl Acad Sci U S A 110(1):E79-88. [PubMed: 23236157] [MGI Ref ID J:192542]
Hesse D; Hommel A; Jaschke A; Moser M; Bernhardt U; Zahn C; Kluge R; Wittschen P; Gruber AD; Al-Hasani H; Joost HG; Schurmann A. 2010. Altered GLUT4 trafficking in adipocytes in the absence of the GTPase Arfrp1. Biochem Biophys Res Commun 394(4):896-903. [PubMed: 20230794] [MGI Ref ID J:159231]
Hofmann SM; Zhou L; Perez-Tilve D; Greer T; Grant E; Wancata L; Thomas A; Pfluger PT; Basford JE; Gilham D; Herz J; Tschop MH; Hui DY. 2007. Adipocyte LDL receptor-related protein-1 expression modulates postprandial lipid transport and glucose homeostasis in mice. J Clin Invest 117(11):3271-82. [PubMed: 17948131] [MGI Ref ID J:127398]
Hommel A; Hesse D; Volker W; Jaschke A; Moser M; Engel T; Bluher M; Zahn C; Chadt A; Ruschke K; Vogel H; Kluge R; Robenek H; Joost HG; Schurmann A. 2010. The ARF-like GTPase ARFRP1 is essential for lipid droplet growth and is involved in the regulation of lipolysis. Mol Cell Biol 30(5):1231-42. [PubMed: 20038528] [MGI Ref ID J:161742]
Jonker JW; Suh JM; Atkins AR; Ahmadian M; Li P; Whyte J; He M; Juguilon H; Yin YQ; Phillips CT; Yu RT; Olefsky JM; Henry RR; Downes M; Evans RM. 2012. A PPARgamma-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis. Nature 485(7398):391-4. [PubMed: 22522926] [MGI Ref ID J:183996]
Kumar A; Lawrence JC Jr; Jung DY; Ko HJ; Keller SR; Kim JK; Magnuson MA; Harris TE. 2010. Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism. Diabetes 59(6):1397-406. [PubMed: 20332342] [MGI Ref ID J:169357]
Lenz LS; Marx J; Chamulitrat W; Kaiser I; Grone HJ; Liebisch G; Schmitz G; Elsing C; Straub BK; Fullekrug J; Stremmel W; Herrmann T. 2011. Adipocyte-specific inactivation of Acyl-CoA synthetase fatty acid transport protein 4 (Fatp4) in mice causes adipose hypertrophy and alterations in metabolism of complex lipids under high fat diet. J Biol Chem 286(41):35578-87. [PubMed: 21808061] [MGI Ref ID J:177596]
Li P; Fan W; Xu J; Lu M; Yamamoto H; Auwerx J; Sears DD; Talukdar S; Oh D; Chen A; Bandyopadhyay G; Scadeng M; Ofrecio JM; Nalbandian S; Olefsky JM. 2011. Adipocyte NCoR knockout decreases PPARgamma phosphorylation and enhances PPARgamma activity and insulin sensitivity. Cell 147(4):815-26. [PubMed: 22078880] [MGI Ref ID J:178828]
Luo W; Cao J; Li J; He W. 2008. Adipose tissue-specific PPARgamma deficiency increases resistance to oxidative stress. Exp Gerontol 43(3):154-63. [PubMed: 18083318] [MGI Ref ID J:132506]
Mao J; Yang T; Gu Z; Heird WC; Finegold MJ; Lee B; Wakil SJ. 2009. aP2-Cre-mediated inactivation of acetyl-CoA carboxylase 1 causes growth retardation and reduced lipid accumulation in adipose tissues. Proc Natl Acad Sci U S A 106(41):17576-81. [PubMed: 19805143] [MGI Ref ID J:153681]
Martens K; Bottelbergs A; Baes M. 2010. Ectopic recombination in the central and peripheral nervous system by aP2/FABP4-Cre mice: implications for metabolism research. FEBS Lett 584(5):1054-8. [PubMed: 20138876] [MGI Ref ID J:157524]
Martens K; Bottelbergs A; Peeters A; Jacobs F; Espeel M; Carmeliet P; Van Veldhoven PP; Baes M. 2012. Peroxisome deficient aP2-Pex5 knockout mice display impaired white adipocyte and muscle function concomitant with reduced adrenergic tone. Mol Genet Metab 107(4):735-47. [PubMed: 23141464] [MGI Ref ID J:190874]
Minamino T; Orimo M; Shimizu I; Kunieda T; Yokoyama M; Ito T; Nojima A; Nabetani A; Oike Y; Matsubara H; Ishikawa F; Komuro I. 2009. A crucial role for adipose tissue p53 in the regulation of insulin resistance. Nat Med 15(9):1082-7. [PubMed: 19718037] [MGI Ref ID J:154323]
Nadra K; Medard JJ; Mul JD; Han GS; Gres S; Pende M; Metzger D; Chambon P; Cuppen E; Saulnier-Blache JS; Carman GM; Desvergne B; Chrast R. 2012. Cell autonomous lipin 1 function is essential for development and maintenance of white and brown adipose tissue. Mol Cell Biol 32(23):4794-810. [PubMed: 23028044] [MGI Ref ID J:192733]
Nadra K; Medard JJ; Quignodon L; Verheijen MH; Desvergne B; Chrast R. 2012. Epineurial adipocytes are dispensable for Schwann cell myelination. J Neurochem 123(5):662-7. [PubMed: 22849425] [MGI Ref ID J:190578]
Pan D; Fujimoto M; Lopes A; Wang YX. 2009. Twist-1 is a PPARdelta-inducible, negative-feedback regulator of PGC-1alpha in brown fat metabolism. Cell 137(1):73-86. [PubMed: 19345188] [MGI Ref ID J:147973]
Pardo R; Enguix N; Lasheras J; Feliu JE; Kralli A; Villena JA. 2011. Rosiglitazone-induced mitochondrial biogenesis in white adipose tissue is independent of peroxisome proliferator-activated receptor gamma coactivator-1alpha. PLoS One 6(11):e26989. [PubMed: 22087241] [MGI Ref ID J:180984]
Paschos GK; Ibrahim S; Song WL; Kunieda T; Grant G; Reyes TM; Bradfield CA; Vaughan CH; Eiden M; Masoodi M; Griffin JL; Wang F; Lawson JA; Fitzgerald GA. 2012. Obesity in mice with adipocyte-specific deletion of clock component Arntl. Nat Med 18(12):1768-77. [PubMed: 23142819] [MGI Ref ID J:190442]
Polak P; Cybulski N; Feige JN; Auwerx J; Ruegg MA; Hall MN. 2008. Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration. Cell Metab 8(5):399-410. [PubMed: 19046571] [MGI Ref ID J:143749]
Pospisilik JA; Schramek D; Schnidar H; Cronin SJ; Nehme NT; Zhang X; Knauf C; Cani PD; Aumayr K; Todoric J; Bayer M; Haschemi A; Puviindran V; Tar K; Orthofer M; Neely GG; Dietzl G; Manoukian A; Funovics M; Prager G; Wagner O; Ferrandon D; Aberger F; HuiCC; Esterbauer H; Penninger JM. 2010. Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. Cell 140(1):148-60. [PubMed: 20074523] [MGI Ref ID J:166285]
Putnam K; Batifoulier-Yiannikouris F; Bharadwaj KG; Lewis E; Karounos M; Daugherty A; Cassis LA. 2012. Deficiency of angiotensin type 1a receptors in adipocytes reduces differentiation and promotes hypertrophy of adipocytes in lean mice. Endocrinology 153(10):4677-86. [PubMed: 22919058] [MGI Ref ID J:192945]
Qian SW; Tang Y; Li X; Liu Y; Zhang YY; Huang HY; Xue RD; Yu HY; Guo L; Gao HD; Liu Y; Sun X; Li YM; Jia WP; Tang QQ. 2013. BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis. Proc Natl Acad Sci U S A 110(9):E798-807. [PubMed: 23388637] [MGI Ref ID J:195212]
Ryu MJ; Kim SJ; Kim YK; Choi MJ; Tadi S; Lee MH; Lee SE; Chung HK; Jung SB; Kim HJ; Jo YS; Kim KS; Lee SH; Kim JM; Kweon GR; Park KC; Lee JU; Kong YY; Lee CH; Chung J; Shong M. 2013. Crif1 deficiency reduces adipose OXPHOS capacity and triggers inflammation and insulin resistance in mice. PLoS Genet 9(3):e1003356. [PubMed: 23516375] [MGI Ref ID J:195282]
Sabio G; Das M; Mora A; Zhang Z; Jun JY; Ko HJ; Barrett T; Kim JK; Davis RJ. 2008. A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science 322(5907):1539-43. [PubMed: 19056984] [MGI Ref ID J:142035]
Shimizu I; Yoshida Y; Katsuno T; Tateno K; Okada S; Moriya J; Yokoyama M; Nojima A; Ito T; Zechner R; Komuro I; Kobayashi Y; Minamino T. 2012. p53-induced adipose tissue inflammation is critically involved in the development of insulin resistance in heart failure. Cell Metab 15(1):51-64. [PubMed: 22225876] [MGI Ref ID J:182322]
Singh R; Xiang Y; Wang Y; Baikati K; Cuervo AM; Luu YK; Tang Y; Pessin JE; Schwartz GJ; Czaja MJ. 2009. Autophagy regulates adipose mass and differentiation in mice. J Clin Invest 119(11):3329-39. [PubMed: 19855132] [MGI Ref ID J:154591]
Starkey JD; Yamamoto M; Yamamoto S; Goldhamer DJ. 2011. Skeletal muscle satellite cells are committed to myogenesis and do not spontaneously adopt nonmyogenic fates. J Histochem Cytochem 59(1):33-46. [PubMed: 21339173] [MGI Ref ID J:169754]
Sumara G; Sumara O; Kim JK; Karsenty G. 2012. Gut-derived serotonin is a multifunctional determinant to fasting adaptation. Cell Metab 16(5):588-600. [PubMed: 23085101] [MGI Ref ID J:190895]
Sung HK; Doh KO; Son JE; Park JG; Bae Y; Choi S; Nelson SM; Cowling R; Nagy K; Michael IP; Koh GY; Adamson SL; Pawson T; Nagy A. 2013. Adipose vascular endothelial growth factor regulates metabolic homeostasis through angiogenesis. Cell Metab 17(1):61-72. [PubMed: 23312284] [MGI Ref ID J:195071]
Terrand J; Bruban V; Zhou L; Gong W; El Asmar Z; May P; Zurhove K; Haffner P; Philippe C; Woldt E; Matz RL; Gracia C; Metzger D; Auwerx J; Herz J; Boucher P. 2009. LRP1 controls intracellular cholesterol storage and fatty acid synthesis through modulation of Wnt signaling. J Biol Chem 284(1):381-8. [PubMed: 18990694] [MGI Ref ID J:146007]
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Urs S; Venkatesh D; Tang Y; Henderson T; Yang X; Friesel RE; Rosen CJ; Liaw L. 2010. Sprouty1 is a critical regulatory switch of mesenchymal stem cell lineage allocation. FASEB J 24(9):3264-73. [PubMed: 20410440] [MGI Ref ID J:163565]
Wang L; Xu S; Lee JE; Baldridge A; Grullon S; Peng W; Ge K. 2013. Histone H3K9 methyltransferase G9a represses PPARgamma expression and adipogenesis. EMBO J 32(1):45-59. [PubMed: 23178591] [MGI Ref ID J:192309]
Wang ZV; Deng Y; Wang QA; Sun K; Scherer PE. 2010. Identification and characterization of a promoter cassette conferring adipocyte-specific gene expression. Endocrinology 151(6):2933-9. [PubMed: 20363877] [MGI Ref ID J:160881]
Wu JW; Wang SP; Casavant S; Moreau A; Yang GS; Mitchell GA. 2012. Fasting energy homeostasis in mice with adipose deficiency of desnutrin/adipose triglyceride lipase. Endocrinology 153(5):2198-207. [PubMed: 22374972] [MGI Ref ID J:185000]
Wueest S; Rapold RA; Schoenle EJ; Konrad D. 2010. Fas activation in adipocytes impairs insulin-stimulated glucose uptake by reducing Akt. FEBS Lett 584(19):4187-92. [PubMed: 20828573] [MGI Ref ID J:164421]
Wueest S; Rapold RA; Schumann DM; Rytka JM; Schildknecht A; Nov O; Chervonsky AV; Rudich A; Schoenle EJ; Donath MY; Konrad D. 2010. Deletion of Fas in adipocytes relieves adipose tissue inflammation and hepatic manifestations of obesity in mice. J Clin Invest 120(1):191-202. [PubMed: 19955656] [MGI Ref ID J:156776]
Yang C; Jin C; Li X; Wang F; McKeehan WL; Luo Y. 2012. Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB. PLoS One 7(3):e33870. [PubMed: 22442730] [MGI Ref ID J:187036]
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Zhang Y; Goldman S; Baerga R; Zhao Y; Komatsu M; Jin S. 2009. Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis. Proc Natl Acad Sci U S A 106(47):19860-5. [PubMed: 19910529] [MGI Ref ID J:154736]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX12
Colony Maintenance
Breeding & Husbandry When maintaining a live colony, these mice are bred as hemizygotes. Mating System Inbred x Hemizygote (Female x Male) 01-MAR-06 Diet Information LabDiet® 5K52/5K67
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $232.00 Female or Male Hemizygous for Tg(Fabp4-cre)1Rev
Price per Pair (US dollars $) Pair Genotype $296.00 Hemizygous for Tg(Fabp4-cre)1Rev x Noncarrier $296.00 Noncarrier x Hemizygous for Tg(Fabp4-cre)1Rev $464.00 Hemizygous for Tg(Fabp4-cre)1Rev x Hemizygous for Tg(Fabp4-cre)1Rev Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
| Pricing for International shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $301.60 Female or Male Hemizygous for Tg(Fabp4-cre)1Rev
Price per Pair (US dollars $) Pair Genotype $384.80 Hemizygous for Tg(Fabp4-cre)1Rev x Noncarrier $384.80 Noncarrier x Hemizygous for Tg(Fabp4-cre)1Rev $603.20 Hemizygous for Tg(Fabp4-cre)1Rev x Hemizygous for Tg(Fabp4-cre)1Rev Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
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Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
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|---|---|---|
| Noncarrier | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
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In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.