Strain Name: |
B6.Cg-Qkqk-2J/J |
|---|---|
Stock Number: |
005089 |
Availability: | Repository- Live |
General Terms and Conditions |
| Former Name |
B.Cg m +/+ Leprdb-Qkqk-2J/J (Changed: 29-AUG-08
) |
|
BKS.Cg m +/+ Leprdb-Qkqk-2J/J (Changed: 25-AUG-06
) | |
| Genes & Alleles | Qk; Qkqk-2J; |
Product Information
Strain Details
Type JAX® GEMM® Strain - Congenic Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Spontaneous Mutation Species laboratory mouse Generation F99+F3N5 (07-DEC-07) Appearance
black, unaffected
Related Genotype: a/a Qkqk-2J/+Important Note
This strain might still be segregating for m and Leprdb although neither mutation has been seen phenotypically since before 2005.Strain Description
Qkqk-2J homozygotes display rapid tremors by approximately 2 weeks of age. Histological examination at 3 weeks of age reveals holes in the striatum of the cortex and cerebellum and in the myelin of the spinal cord. Vision and hearing appear normal.Strain Development
The quaking 2 Jackson mutation arose spontaneously in November, 2003, in the strain BKS.Cg-m +/+ Leprdb/J at The Jackson Laboratory when that strain was at F99. The parents of the quaking pups were heterozygous carriers for Leprdb and it is probable that they were heterozygous for misty (m) as well. Siblings of a first generation quaking mutant were bred together and proven to be heterozygous by producing quaking and wild-type offspring. The line was again bred from progeny tested heterozygous siblings and an F3 homozygous female was then the donor for ovarian transplant. The host was bred to C57BL/6J to produce N1 heterozygous offspring, which were intercrossed. Neither Leprdb nor m homozygotes have been found since the F1 generation, but these recessive mutations may still be segregating in this line.
Mammalian Phenotype Terms assigned by genotype |
Gene & Allele Details
| Allele Symbol | Qkqk-2J | ||
|---|---|---|---|
| Allele Name | quaking 2 Jackson | ||
| Strain of Origin | BKS.Cg-m +/+ Leprdb/J | ||
| Gene Symbol and Name | Qk, quaking | ||
| Chromosome | 17 | ||
| Gene Common Name(s) | DKFZp586I0923; Hqk; QK1; QK3; QkI; l(17)-1Wis; l17Wis1; lethal, Chr 17, U Wisconsin 1; | ||
Control Information
| Control | ||
|---|---|---|
| +/? from the colony | ||
| Considerations for Choosing Controls | ||
Genotyping Protocols
Leprdb
m (Misty)
Related Strains
Strains carrying other alleles of Qk
000567 B6.Cg-T2J +/+ Qkqk/J 000506 B6C3Fe a/a-Qkqk/J View Strains carrying other alleles of Qk (2 strains)
Additional Web Information
Genetic Quality Control Annual Report
Animal Health Reports
Room Number A1
Research Applications
This mouse can be used to support research in many areas including:Qkqk-2J related
Apoptosis Research
Cell Biology Research
Cell Cycle Regulation
Neurobiology Research
Epilepsy
Neurodegeneration
Tremor Defects
References
Selected Reference(s)
Original article from The Mouse Mutant ResourceHarris BS; Ward-Bailey PF; Johnson KR; Bronson RT; Davisson MT. 2005. Quaking 2 Jackson, a remutation of the Quaking (Qk) gene on Chromosome 17 in the mouse MGI Direct Data Submission :. [MGI Ref ID J:97293]
Price and Supply Information
| Strain Name: | B6.Cg-Qkqk-2J/J |
| Stock Number: | 005089 |
Price Details
IMPORTANT NOTE: Prices are based on shipping destination. To view prices, select your shipping destination.
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement. |
|---|---|
| Supply Notes |
Usually shipped between four and eight weeks of age. This strain is included in the Mouse Mutant Resource collection. Genomic DNA is available for this strain from the Mouse DNA Resource. |
| Licensing | See General Terms and Conditions below |
| Control Information | View Control Information in Strain Details. |
General Terms and Conditions
View JAX® Mice & Services Conditions of Use.
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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