Strain Name:

A.B6 Tyr+-Spnb4qv-7J/J

Stock Number:

005098

Availability:

Repository-Cryopreserved

Description

Strain Information

Former Names A.B6 Tyr+-Spnb4nmf261/J    (Changed: 19-MAY-06 )
A.B6 Tyr+-nmf261/J    (Changed: 08-AUG-05 )
NMF261    (Changed: 31-JAN-05 )
Type Chemically Induced Mutation; Mutant Strain;
Additional information on Genetically Engineered Mutant Mice.
Specieslaboratory mouse

Appearance
brown
Related Genotype: a/a Tyrp1b/Tyrp1b

Description
View strain phenotype and additional information on the Neuroscience Mutagenesis Facility web page for Spnb4qv-7J entry.

Control Information

  Control
   +/? untyped from the colony
 
  Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of Spnb4
001769   B6.B10Sn-Spnb4qv-lnd/J
005753   B6;CByJ-Spnb4qv-9J/J
002996   B6ByJ;D2-Spnb4qv-4J/J
000638   C3FeB6 A/Aw-J-Spnb4qv-J/J
002433   C3H/HeJ-Spnb4qv-lnd2J/J
008522   C57BL/6J-Spnb4qv-11J/J
001028   C57BL/6J-Spnb4qv-3J/J
005449   C57BL/6J-Spnb4qv-8J/J
008521   C;B6-Spnb4qv-10J/J
View Strains carrying other alleles of Spnb4     (9 strains)

Additional Web Information

Genetic Quality Control Annual Report

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms
      assigned by genotype

Spnb4qv-7J/Spnb4qv-7J

        A.B6-Tyr+/J
  • muscle phenotype
  • *normal* muscle phenotype (MGI Ref ID J:82238)
    • pathological examination revealed no abnormalities in muscles of mice ages 43, 49 or 88 days
    • whole muscle mounts of the hindlimb of an 88 day-old mouse stained with bungarotoxin, SV2 and SM31 appeared normal
    • muscle weakness (MGI Ref ID J:82238)
      • mutant mice from the age of 4 weeks have difficulty supporting weight on their hindlimbs and drag them intermittently
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Spnb4qv-7J related

Developmental Biology Research
Growth Defects

Neurobiology Research
Ataxia (Movement) Defects
Neuromuscular Defects
Neuroscience Mutagenesis Facility Strain

Genes & Alleles

Gene & Allele Information

Allele Symbol Spnb4qv-7J
Allele Name quivering 7 Jackson
Allele Type Chemically induced (ENU)
Common Name(s) NMF261; Spnb4nmf261; neuroscience mutagenesis facility, 261;
Strain of OriginA.B6-Tyr+/J
Gene Symbol and Name Spnb4, spectrin beta 4
Chromosome 7
Gene Common Name(s) 1700022P15Rik; 5830426A08Rik; KIAA1642; QV; RIKEN cDNA 1700022P15 gene; RIKEN cDNA 5830426A08 gene; ROSA62; SPTBN3; SpbIV; dyn; lnd; lumbosacral neuroaxonal dystrophy; neuroaxonal dystrophy; neuroscience mutagenesis facility, 261; neuroscience mutagenesis facility, 379; nmf261; nmf379; quivering; qv;
Molecular Note This phenotypic mutation was identified in an ENU mutagenesis screen and shown to be an allele of Spnb4 by complementation testing versus the lumbosacral neuroaxonal dystrophy mutation of this gene. [MGI Ref ID J:82238]

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Optimizing PCR Protocols

References

References

Additional References

Spnb4qv-7J related

JAX Neuroscience Mutagenesis Facility URL: http://www.jax.org/nmf. 2003. Heritable mouse mutants from JAX NMF ENU Mutagenesis Program MGI Direct Data Submission :.  [MGI Ref ID J:82238]

Health & husbandry

Health & Colony Maintenance Information

Currently there no information available for this strain. This may be due to the supply level of this strain.

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations View International pricing
Weeks of AgePrice*Gender
Cryorecovery Fee $1900.00
*Price(s) in US dollars ($)

Additional Supply Details

Pricing for International shipping destinations View USA Canada and Mexico pricing
Weeks of AgePrice*Gender
Cryorecovery Fee $2470.00
*Price(s) in US dollars ($)

Additional Supply Details

Supply Details

Standard SupplyRepository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes
  • Cryorecovery of Strains Needing Progeny Testing.
    The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two untested males and two untested females (two pairs) will be recovered, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the overall recovery time to approximately 25 weeks. However, all pups recovered will be sent.

    Progeny testing is required to identify the genotype of mice of this strain, as a genotyping assay is not available. This type of testing involves breeding the recovered animals and assessing the phenotype of the offspring in order to identify animals carrying the mutation of interest. We can perform the progeny testing for you as a service or we can ship all recovered animals (at least two untested pairs) to you for progeny testing at your facility. If you perform the progeny testing, there is NO guarantee that a carrier will be identified. If we perform progeny testing as a service, additional breeding time will be required. In this case, when a male and female (one pair) are identified that carry the mutation, they and their offspring will be shipped. Delivery time for strains requiring progeny testing often exceeds 25 weeks and may take 12 months or more due to the difficulties in breeding some strains. The progeny testing cost is in addition to the recovery cost and is based on the number of boxes used and the time taken to produce the mice identified as carrying the mutation. Please note that identified pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Please contact Customer Service for more information on the cost of progeny testing for a strain: Tel: 1-800-422-6423 or 1-207-288-5845.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice
    One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 or 1-207-288-5845.

  • This strain is included in the Neuroscience Mutagenesis Facility (NMF).

Control Information

  Control
   +/? untyped from the colony
 
  Considerations for Choosing Controls
  USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
  International - Control Pricing Information for Genetically Engineered Mutant Strains.

General Terms and Conditions


See Terms of Use


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering and Purchasing Information

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Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


Contact information

General inquiries

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phone:207-288-6470
fax:207-288-6655

JAX® Mice & Services Conditions of Use

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