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| Widespread tissue-specific expression of the human histone 1, H2bj, protein (HIST1H2BJ) can be regulated with the administration of doxycycline after breeding a mouse carrying this transgene with another transgenic mouse expressing reverse tetracycline-controlled transactivator protein (rtTA) or tetracycline-controlled transactivator protein (tTA. | |||||||||||||||||||
- Description
- Disease & phenotype
- Genes & alleles
- Genotyping
- Health & care
- References
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- Terms of use
Description
Strain Information
Type Mutant Stock; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Mating System Hemizygote x +/+ sibling (Female x Male) 13-MAY-08 Species laboratory mouse Generation F?+13 (24-MAR-11)
Generation DefinitionsDonating Investigator Elaine Fuchs, The Rockefeller University Important Note
This strain is segregating for Gnat2cpfl3, cone photoreceptor function loss 3, which affects bright light (photopic) vision.Description
These transgenic mice express the human histone 1, H2bj, protein (HIST1H2BJ) and Green Fluorescent Protein (GFP) fusion protein, HIST1H2BJ/GFP, under the control of a tetracycline-responsive promoter element (TRE; tetO). Transgenic expression occurs in widespread fashion. When hemizygotes are bred with another transgenic mouse expressing reverse tetracycline-controlled transactivator protein (rtTA) or tetracycline-controlled transactivator protein (tTA) to create bitransgenic animals, tissue-specific HIST1H2BJ/GFP transgene expression can be regulated with the tetracycline analog, doxycycline. Pulse-chase administration of doxycycline results in retention of signal in rarely dividing, or infrequently cycling, label-retaining cells (LRCs). Potential constitutive transgene expression should be examined in tissues of interest.Development
A transgenic construct containing sequences encoding the human histone 1, H2bj, protein (HIST1H2BJ) and enhanced Green Fluorescent Protein (GFP) fusion protein, HIST1H2BJ/GFP, under the control of a tetracycline-responsive promoter element (TRE) and cytomegalovirus minimal promoter (mCMV), was introduced into CD-1 donor eggs. Founder line Male 47 was subsequently established.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| Considerations for Choosing Controls | ||
Related Strains
Fluorescent Protein Strains
View Fluorescent Protein Strains (358 strains)
003072 ALS/LtJ 006795 B6.Cg-Gnat2cpfl3/Boc 006180 CD10/JlsJ 005052 PN/nBSwUmabJ 002746 SENCARA/PtJ 002747 SENCARB/PtJ 002748 SENCARC/PtJ 006135 STOCK Sgk3fz-ica/McirJ 003773 STOCK Tg(CAG-ECFP)CK6Nagy/J 005645 STOCK Tg(CAG-mRFP1)1F1Hadj/J 004623 STOCK Tg(Fos-lacZ)34Efu/J 005667 STOCK Tg(Neurog3-cre)C1Able/J 003262 STOCK Tg(Trp53A135V)L3Ber/J 005699 STOCK Tg(tetO-Ipf1,EGFP)956.6Macd/J
016836 B6;129S4-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm7(tetO-HIST1H2BJ/GFP)Jae/J
Additional Web Information
Fluorescent Proteins/lacZ Systems
Tet Expression Systems
Phenotype
Phenotype Information
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested. Achromatopsia 4; ACHM4 (GNAT2)
assigned by genotype
The following phenotype relates to a compound genotype created using this strain.
Contact JAX® Services jaxservices@jax.org for customized breeding options.Tg(tetO-HIST1H2BJ/GFP)47Efu/? Waptm2(rtTA)Kuw/Wap+
involves: 129X1/SvJ * CD-1
- normal phenotype
- no abnormal phenotype detected
- knock-in allele expression determined by use of this strain (MGI Ref ID J:148684)
This mouse can be used to support research in many areas including:
GFP relatedCell Biology Research
Cell Cycle Regulation
Transcriptional Regulation
Research Tools
Cell Biology Research
Fluorescent Proteins
Tet Expression Systems
tTA/rtTA Responsive Strains
Gnat2cpfl3 relatedResearch Tools
Fluorescent Proteins
Sensorineural Research
Eye Defects
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Tg(tetO-HIST1H2BJ/GFP)47Efu | ||
|---|---|---|---|
| Allele Name | transgene insertion 47, Elaine Fuchs | ||
| Allele Type | Transgenic (random, expressed) | ||
| Common Name(s) | TRE-EGFP; TRE-H2B-GFP; TRE-mCMV- H2B-GFP; TetO-H2B-GFP; pTRE-H2BGFP; tetO-H2bGFP; | ||
| Mutation Made By | Tudorita Tumbar, | ||
| Strain of Origin | CD-1 | ||
| Site of Expression | These mice express the human histone 1, H2BJ, protein (HIST1H2BJ) and Green Fluorescent Protein (GFP) fusion protein, HIST1H2BJ/GFP, under the control of a tetracycline-responsive promoter element (TRE;tetO). When crossed with mice expressing a tetracycline-transactivator protein (rtTA) or tetracycline-controlled transactivator protein (tTA), tissue specific transgene expression in the bitransgenic progeny can be regulated by the administration of the tetracycline analog, doxycycline. Potential constitutive transgene expression should be examined in tissues of interest. | ||
| Expressed Gene | HIST1H2BJ, histone cluster 1, H2bj, human | ||
| Expressed Gene | GFP, Green Fluorescent Protein, jellyfish | ||
| Green Fluorescent Protein (GFP), derived from the jellyfish Aequorea victoria, is a versatile reporter molecule which has found use in many biological applications. In some constructs the original molecule has been modified in order to enhance its fluorescence intensity (EGFP, enhanced GFP). When utilized in a transgenic construct, tissue expressing sufficient amounts of GFP will fluoresce when exposed to a 488 nm light source. | |||
| Promoter | tetO, tet operator, | ||
| Molecular Note | This transgene contains sequence encoding the human histone 1, H2bj, protein (HIST1H2BJ) and green fluorescent protein fusion protein, HIST1H2BJ/GFP, under the control of a tetracycline-responsive promoter element (TRE) and cytomegalovirus regulatory elements (mCMV). [MGI Ref ID J:90563] | ||
| Allele Symbol | Gnat2cpfl3 | ||
| Allele Name | cone photoreceptor function loss 3 | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | various | ||
| Gene Symbol and Name | Gnat2, guanine nucleotide binding protein, alpha transducing 2 | ||
| Chromosome | 3 | ||
| Gene Common Name(s) | ACHM4; AW490837; GNATC; Gnat-2; Gt-2; Tcalpha; expressed sequence AW490837; | ||
| General Note | This allele has been detected in the following strains either by genotyping or complementation testing: ALS/LtJ, SENCARA/PtJ, SENCARB/PtJ, SENCARC/PtJ, PN/nBSwUmabJ. (J:122428) | ||
| Molecular Note | A single nucleotide substitution of G to A at position 598 in exon 6. This mutation converts codon 200 from aspartic acid to asparagine. [MGI Ref ID J:122428] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Fluorescent Proteins (Generic GFP), Melt Curve Analysis
Fluorescent Proteins (Generic GFP), Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Tumbar T; Guasch G; Greco V; Blanpain C; Lowry WE; Rendl M; Fuchs E. 2004. Defining the epithelial stem cell niche in skin. Science 303(5656):359-63. [PubMed: 14671312] [MGI Ref ID J:90563]
Additional References
Chang B; Dacey MS; Hawes NL; Hitchcock PF; Milam AH; Atmaca-Sonmez P; Nusinowitz S; Heckenlively JR. 2006. Cone photoreceptor function loss-3, a novel mouse model of achromatopsia due to a mutation in Gnat2. Invest Ophthalmol Vis Sci 47(11):5017-21. [PubMed: 17065522] [MGI Ref ID J:122428]
Gnat2cpfl3 relatedTg(tetO-HIST1H2BJ/GFP)47Efu relatedAlexander JJ; Umino Y; Everhart D; Chang B; Min SH; Li Q; Timmers AM; Hawes NL; Pang JJ; Barlow RB; Hauswirth WW. 2007. Restoration of cone vision in a mouse model of achromatopsia. Nat Med 13(6):685-7. [PubMed: 17515894] [MGI Ref ID J:121897]
Allen AE; Cameron MA; Brown TM; Vugler AA; Lucas RJ. 2010. Visual responses in mice lacking critical components of all known retinal phototransduction cascades. PLoS One 5(11):e15063. [PubMed: 21124780] [MGI Ref ID J:167121]
Altimus CM; Guler AD; Alam NM; Arman AC; Prusky GT; Sampath AP; Hattar S. 2010. Rod photoreceptors drive circadian photoentrainment across a wide range of light intensities. Nat Neurosci 13(9):1107-12. [PubMed: 20711184] [MGI Ref ID J:165280]
Chang B; Dacey MS; Hawes NL; Hitchcock PF; Milam AH; Atmaca-Sonmez P; Nusinowitz S; Heckenlively JR. 2006. Cone photoreceptor function loss-3, a novel mouse model of achromatopsia due to a mutation in Gnat2. Invest Ophthalmol Vis Sci 47(11):5017-21. [PubMed: 17065522] [MGI Ref ID J:122428]
Chang B; Hawes NL; Hurd RE; Wang J; Howell D; Davisson MT; Roderick TH; Nusinowitz S; Heckenlively JR. 2005. Mouse models of ocular diseases. Vis Neurosci 22(5):587-93. [PubMed: 16332269] [MGI Ref ID J:156373]
Deng WT; Sakurai K; Liu J; Dinculescu A; Li J; Pang J; Min SH; Chiodo VA; Boye SL; Chang B; Kefalov VJ; Hauswirth WW. 2009. Functional interchangeability of rod and cone transducin alpha-subunits. Proc Natl Acad Sci U S A 106(42):17681-6. [PubMed: 19815523] [MGI Ref ID J:153749]
Naarendorp F; Esdaille TM; Banden SM; Andrews-Labenski J; Gross OP; Pugh EN Jr. 2010. Dark light, rod saturation, and the absolute and incremental sensitivity of mouse cone vision. J Neurosci 30(37):12495-507. [PubMed: 20844144] [MGI Ref ID J:164666]
Nusinowitz S; Ridder WH 3rd; Ramirez J. 2007. Temporal response properties of the primary and secondary rod-signaling pathways in normal and Gnat2 mutant mice. Exp Eye Res 84(6):1104-14. [PubMed: 17408617] [MGI Ref ID J:126462]
Umino Y; Solessio E; Barlow RB. 2008. Speed, spatial, and temporal tuning of rod and cone vision in mouse. J Neurosci 28(1):189-98. [PubMed: 18171936] [MGI Ref ID J:131050]
Wang YV; Weick M; Demb JB. 2011. Spectral and temporal sensitivity of cone-mediated responses in mouse retinal ganglion cells. J Neurosci 31(21):7670-81. [PubMed: 21613480] [MGI Ref ID J:191557]
Won J; Shi LY; Hicks W; Wang J; Hurd R; Naggert JK; Chang B; Nishina PM. 2011. Mouse model resources for vision research. J Ophthalmol 2011:391384. [PubMed: 21052544] [MGI Ref ID J:166679]
Brennand K; Huangfu D; Melton D. 2007. All beta Cells Contribute Equally to Islet Growth and Maintenance. PLoS Biol 5(7):e163. [PubMed: 17535113] [MGI Ref ID J:124045]
Clowney EJ; LeGros MA; Mosley CP; Clowney FG; Markenskoff-Papadimitriou EC; Myllys M; Barnea G; Larabell CA; Lomvardas S. 2012. Nuclear aggregation of olfactory receptor genes governs their monogenic expression. Cell 151(4):724-37. [PubMed: 23141535] [MGI Ref ID J:193207]
Creamer BA; Triplett AA; Wagner KU. 2009. Longitudinal analysis of mammogenesis using a novel tetracycline-inducible mouse model and in vivo imaging. Genesis 47(4):234-45. [PubMed: 19208431] [MGI Ref ID J:148684]
Dos Santos CO; Rebbeck C; Rozhkova E; Valentine A; Samuels A; Kadiri LR; Osten P; Harris EY; Uren PJ; Smith AD; Hannon GJ. 2013. Molecular hierarchy of mammary differentiation yields refined markers of mammary stem cells. Proc Natl Acad Sci U S A 110(18):7123-30. [PubMed: 23580620] [MGI Ref ID J:196139]
Greco V; Chen T; Rendl M; Schober M; Pasolli HA; Stokes N; Dela Cruz-Racelis J; Fuchs E. 2009. A two-step mechanism for stem cell activation during hair regeneration. Cell Stem Cell 4(2):155-69. [PubMed: 19200804] [MGI Ref ID J:149690]
Gros J; Hu JK; Vinegoni C; Feruglio PF; Weissleder R; Tabin CJ. 2010. WNT5A/JNK and FGF/MAPK pathways regulate the cellular events shaping the vertebrate limb bud. Curr Biol 20(22):1993-2002. [PubMed: 21055947] [MGI Ref ID J:166897]
Hirata A; Utikal J; Yamashita S; Aoki H; Watanabe A; Yamamoto T; Okano H; Bardeesy N; Kunisada T; Ushijima T; Hara A; Jaenisch R; Hochedlinger K; Yamada Y. 2013. Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium. Development 140(1):66-75. [PubMed: 23222438] [MGI Ref ID J:191050]
Liu P; Fu X; Johnson RL. 2011. Efficient in vivo doxycycline and cre recombinase-mediated inducible transgene activation in the murine trabecular meshwork. Invest Ophthalmol Vis Sci 52(2):969-74. [PubMed: 21051732] [MGI Ref ID J:171549]
Maruyama T; Mirando AJ; Deng CX; Hsu W. 2010. The balance of WNT and FGF signaling influences mesenchymal stem cell fate during skeletal development. Sci Signal 3(123):ra40. [PubMed: 20501936] [MGI Ref ID J:185410]
Murphy PA; Kim TN; Lu G; Bollen AW; Schaffer CB; Wang RA. 2012. Notch4 normalization reduces blood vessel size in arteriovenous malformations. Sci Transl Med 4(117):117ra8. [PubMed: 22261032] [MGI Ref ID J:183703]
Plichta KA; Mathers JL; Gestl SA; Glick AB; Gunther EJ. 2012. Basal but not luminal mammary epithelial cells require PI3K/mTOR signaling for Ras-driven overgrowth. Cancer Res 72(22):5856-66. [PubMed: 23010075] [MGI Ref ID J:192879]
Roth S; Franken P; Sacchetti A; Kremer A; Anderson K; Sansom O; Fodde R. 2012. Paneth cells in intestinal homeostasis and tissue injury. PLoS One 7(6):e38965. [PubMed: 22745693] [MGI Ref ID J:187938]
Schepers K; Hsiao EC; Garg T; Scott MJ; Passegue E. 2012. Activated Gs signaling in osteoblastic cells alters the hematopoietic stem cell niche in mice. Blood 120(17):3425-35. [PubMed: 22859604] [MGI Ref ID J:191308]
Seidel K; Ahn CP; Lyons D; Nee A; Ting K; Brownell I; Cao T; Carano RA; Curran T; Schober M; Fuchs E; Joyner A; Martin GR; de Sauvage FJ; Klein OD. 2010. Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor. Development 137(22):3753-61. [PubMed: 20978073] [MGI Ref ID J:167067]
Sotiropoulou PA; Karambelas AE; Debaugnies M; Candi A; Bouwman P; Moers V; Revenco T; Rocha AS; Sekiguchi K; Jonkers J; Blanpain C. 2013. BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny. Genes Dev 27(1):39-51. [PubMed: 23271346] [MGI Ref ID J:192592]
Tang W; Zeve D; Suh JM; Bosnakovski D; Kyba M; Hammer RE; Tallquist MD; Graff JM. 2008. White fat progenitor cells reside in the adipose vasculature. Science 322(5901):583-6. [PubMed: 18801968] [MGI Ref ID J:178521]
Wang Y; Sacchetti A; van Dijk MR; van der Zee M; van der Horst PH; Joosten R; Burger CW; Grootegoed JA; Blok LJ; Fodde R. 2012. Identification of quiescent, stem-like cells in the distal female reproductive tract. PLoS One 7(7):e40691. [PubMed: 22848396] [MGI Ref ID J:189710]
Wei W; Zeve D; Suh JM; Wang X; Du Y; Zerwekh JE; Dechow PC; Graff JM; Wan Y. 2011. Biphasic and Dosage-Dependent Regulation of Osteoclastogenesis by beta-Catenin. Mol Cell Biol 31(23):4706-19. [PubMed: 21876000] [MGI Ref ID J:178340]
Wilson A; Laurenti E; Oser G; van der Wath RC; Blanco-Bose W; Jaworski M; Offner S; Dunant CF; Eshkind L; Bockamp E; Lio P; Macdonald HR; Trumpp A. 2008. Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. Cell 135(6):1118-29. [PubMed: 19062086] [MGI Ref ID J:147599]
Zaidi MR; Davis S; Noonan FP; Graff-Cherry C; Hawley TS; Walker RL; Feigenbaum L; Fuchs E; Lyakh L; Young HA; Hornyak TJ; Arnheiter H; Trinchieri G; Meltzer PS; De Fabo EC; Merlino G. 2011. Interferon-gamma links ultraviolet radiation to melanomagenesis in mice. Nature 469(7331):548-53. [PubMed: 21248750] [MGI Ref ID J:172414]
Zeve D; Seo J; Suh JM; Stenesen D; Tang W; Berglund ED; Wan Y; Williams LJ; Lim A; Martinez MJ; McKay RM; Millay DP; Olson EN; Graff JM. 2012. Wnt signaling activation in adipose progenitors promotes insulin-independent muscle glucose uptake. Cell Metab 15(4):492-504. [PubMed: 22482731] [MGI Ref ID J:184458]
Zhang YV; Cheong J; Ciapurin N; McDermitt DJ; Tumbar T. 2009. Distinct self-renewal and differentiation phases in the niche of infrequently dividing hair follicle stem cells. Cell Stem Cell 5(3):267-78. [PubMed: 19664980] [MGI Ref ID J:154136]
Zhou H; Liu Y; He F; Mo L; Sun TT; Wu XR. 2010. Temporally and spatially controllable gene expression and knockout in mouse urothelium. Am J Physiol Renal Physiol 299(2):F387-95. [PubMed: 20427471] [MGI Ref ID J:162511]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX12
Colony Maintenance
Breeding & Husbandry When maintaining a live colony, these mice are maintained as hemizygote. Mating System Hemizygote x +/+ sibling (Female x Male) 13-MAY-08 Diet Information LabDiet® 5K52/5K67
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $232.00 Female or Male Hemizygous for Tg(tetO-HIST1H2BJ/GFP)47Efu
Price per Pair (US dollars $) Pair Genotype $302.00 Hemizygous for Tg(tetO-HIST1H2BJ/GFP)47Efu x Noncarrier $302.00 Noncarrier x Hemizygous for Tg(tetO-HIST1H2BJ/GFP)47Efu Standard Supply
Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.
| Pricing for International shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $301.60 Female or Male Hemizygous for Tg(tetO-HIST1H2BJ/GFP)47Efu
Price per Pair (US dollars $) Pair Genotype $392.60 Hemizygous for Tg(tetO-HIST1H2BJ/GFP)47Efu x Noncarrier $392.60 Noncarrier x Hemizygous for Tg(tetO-HIST1H2BJ/GFP)47Efu Standard Supply
Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.
|
|
|
Standard Supply
Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Important Note
This strain is segregating for Gnat2cpfl3, cone photoreceptor function loss 3, which affects bright light (photopic) vision.
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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