Strain Name:

B6.129-Mmp7tm1Lmm/J

Stock Number:

005111

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Availability:

Repository- Live

Mutant mice have impaired innate host defense response and are more susceptible to bacterial infection of the small intestine mucosal epithelium. Wound repair (reepithelialization) is defective and the mice show reduced apoptosis in prostrate and pancreatic tissue. This mutant mouse strain may be useful in studies related to intestinal and pancreatic tumorigenesis, epithelial wound repair, inflammation and mucosal immune response.

Description

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
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Additional information on Congenic nomenclature.
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Specieslaboratory mouse
GenerationN11F?+F14N1F3 (11-MAY-11)
Generation Definitions
 
Donating Investigator William C. Parks,   University of Washington

Description
Mice that are homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. No gene product (mRNA) is detected by Northern blot analysis of the small intestine. Immunohistochemical analysis of intestinal tissue from homozygotes does not detect the gene product (protein) in Paneth cells. Mutant mice have impaired innate host defense response due to the lack of mature crypt defensin proteins in intestinal epithelium. These mice are more susceptible to bacterial infection of the small intestine mucosal epithelium. Wound repair (reepithelialization) and neutrophil infiltration following respiratory airway injury is defective. Apoptosis is reduced in prostate tissue following castration, and in pancreatic acinar cells following pancreatic duct ligation. This mutant mouse strain may be useful in studies related to intestinal and pancreatic tumorigenesis, epithelial wound repair, inflammation and mucosal immune response.

Development
A targeting vector containing neomycin resistance and herpes simplex virus thymidine kinase genes was used to disrupt 95 nucleotides in exon 4. The construct was electroporated into 129 derived R1 embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6 blastocysts. The donating investigator reported that the resulting chimeric animals were crossed to C57BL/6 mice, and then backcrossed to the same for 11 generations (January 2004; see SNP note below). Heterozygotes were bred to generate homozygotes.

A 32 SNP (single nucleotide polymorphism) panel analysis, with 27 markers covering all 19 chromosomes and the X chromosome, as well as 5 markers that distinguish between the C57BL/6J and C57BL/6N substrains, was performed on the rederived living colony at The Jackson Laboratory Repository. While the 27 markers throughout the genome suggested a C57BL/6 genetic background, 1 of 5 markers that determine C57BL/6J from C57BL/6N were found to be segregating. These data suggest the mice sent to The Jackson Laboratory Repository were on a mixed C57BL/6J ; C57BL/6N genetic background.

Control Information

  Control
   000664 C57BL/6J (approximate)
 
  Considerations for Choosing Controls

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Mmp7tm1Lmm/Mmp7tm1Lmm

        B6.129-Mmp7tm1Lmm
  • mortality/aging
  • decreased sensitivity to induced morbidity/mortality
    • survival rate post-myocardial infarction is increased compared to in similarly treated wild-type mice   (MGI Ref ID J:122893)
  • increased sensitivity to xenobiotic induced morbidity/mortality
    • mice fed 4% DSS water exhibit bloody diarrhea and all die after 9 days unlike similarly treated wild-type mice   (MGI Ref ID J:149388)
    • mice fed 2% DSS water exhibit lose 30% body weight and all die by day 13 unlike similarly treated wild-type mice   (MGI Ref ID J:149388)
  • cardiovascular system phenotype
  • abnormal PR interval
    • PR interval is not prolonged following myocardial infarction unlike in similarly treated wild-type mice   (MGI Ref ID J:122893)
  • abnormal sinoatrial node conduction
    • following myocardial infarction left ventricle epicardial conduction from apex to base is faster than in similarly treated wild-type mice   (MGI Ref ID J:122893)
  • altered response to myocardial infarction
    • survival rate post-myocardial infarction is increased compared to in similarly treated wild-type mice   (MGI Ref ID J:122893)
    • PR interval is not prolonged following myocardial infarction unlike in similarly treated wild-type mice   (MGI Ref ID J:122893)
    • following myocardial infarction left ventricle epicardial conduction from apex to base is faster than in similarly treated wild-type mice   (MGI Ref ID J:122893)
  • digestive/alimentary phenotype
  • *normal* digestive/alimentary phenotype
    • cecal flora is normal   (MGI Ref ID J:149388)
    • diarrhea
      • mice fed 4% DSS water exhibit bloody diarrhea unlike similarly treated wild-type mice   (MGI Ref ID J:149388)
    • increased susceptibility to induced colitis
      • mice fed 4% DSS water exhibit bloody diarrhea and all die after 9 days unlike similarly treated wild-type mice   (MGI Ref ID J:149388)
      • mice fed 2% DSS water exhibit lose 30% body weight and all die by day 13 unlike similarly treated wild-type mice   (MGI Ref ID J:149388)
      • mice fed 1% DSS water develop multiple erosions and intense inflammation in the cecum and colon with crypt destruction, mucosal ulcerations, erosions, and infiltration of leukocytes into mucosal tissue unlike similarly treated wild-type mice   (MGI Ref ID J:149388)
    • intestinal ulcer
      • in mice fed 1% DSS water   (MGI Ref ID J:149388)
  • immune system phenotype
  • increased interleukin-1 beta secretion
    • cecum and colon organ cultures produce more IL1beta than cultures from wild-type mice   (MGI Ref ID J:149388)
    • cecum and colon organ cultures from mice fed DSS water exhibit increased IL1beta production compared with cultures from similarly treated wild-type mice   (MGI Ref ID J:149388)
  • increased susceptibility to induced colitis
    • mice fed 4% DSS water exhibit bloody diarrhea and all die after 9 days unlike similarly treated wild-type mice   (MGI Ref ID J:149388)
    • mice fed 2% DSS water exhibit lose 30% body weight and all die by day 13 unlike similarly treated wild-type mice   (MGI Ref ID J:149388)
    • mice fed 1% DSS water develop multiple erosions and intense inflammation in the cecum and colon with crypt destruction, mucosal ulcerations, erosions, and infiltration of leukocytes into mucosal tissue unlike similarly treated wild-type mice   (MGI Ref ID J:149388)
  • homeostasis/metabolism phenotype
  • altered response to myocardial infarction
    • survival rate post-myocardial infarction is increased compared to in similarly treated wild-type mice   (MGI Ref ID J:122893)
    • PR interval is not prolonged following myocardial infarction unlike in similarly treated wild-type mice   (MGI Ref ID J:122893)
    • following myocardial infarction left ventricle epicardial conduction from apex to base is faster than in similarly treated wild-type mice   (MGI Ref ID J:122893)
  • impaired wound healing
    • 24 hours following tracheal wound induction, mice exhibit no evidence of epithelial migration and fail to exhibit reduction in wound size unlike similarly treated wild-type mice   (MGI Ref ID J:115243)
  • increased sensitivity to xenobiotic induced morbidity/mortality
    • mice fed 4% DSS water exhibit bloody diarrhea and all die after 9 days unlike similarly treated wild-type mice   (MGI Ref ID J:149388)
    • mice fed 2% DSS water exhibit lose 30% body weight and all die by day 13 unlike similarly treated wild-type mice   (MGI Ref ID J:149388)
  • tumorigenesis
  • increased tumor incidence
    • mice injected with Lewis lung carcinoma cells exhibit an increase in tumors compared with similarly treated wild-type mice   (MGI Ref ID J:105098)
  • growth/size/body phenotype
  • weight loss
    • mice fed 2% DSS water exhibit lose 30% body weight unlike similarly treated wild-type mice   (MGI Ref ID J:149388)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Mmp7tm1Lmm/Mmp7tm1Lmm

        involves: 129S1/Sv * 129X1/SvJ * C57BL/6
  • cardiovascular system phenotype
  • abnormal induced retinal neovascularization
    • following corneal wounding, mice exhibit a greater areas of neovascularization compared to in similarly treated wild-type mice   (MGI Ref ID J:119224)
    • however, corneal wound re-epithelialization is normal and implantation of bFGF (Fgf2) pellets restores normal neovascularization   (MGI Ref ID J:119224)
  • vision/eye phenotype
  • abnormal induced retinal neovascularization
    • following corneal wounding, mice exhibit a greater areas of neovascularization compared to in similarly treated wild-type mice   (MGI Ref ID J:119224)
    • however, corneal wound re-epithelialization is normal and implantation of bFGF (Fgf2) pellets restores normal neovascularization   (MGI Ref ID J:119224)

Mmp7tm1Lmm/Mmp7tm1Lmm

        involves: 129S1/Sv * 129X1/SvJ
  • immune system phenotype
  • *normal* immune system phenotype
    • mice exhibit normal contact hypersensitivity in response to DNFB   (MGI Ref ID J:55723)
    • decreased susceptibility to bacterial infection
      • 4 hours after infection with Pseudomonas aeruginosa, mice exhibit less severe pneumonia than in similarly treated wild-type mice   (MGI Ref ID J:153651)
      • however, mice exhibit normal response 24 hours after P. aeruginosa infection   (MGI Ref ID J:153651)
  • homeostasis/metabolism phenotype
  • decreased susceptibility to injury
    • following pancreatic duct ligation, mice exhibit less acinar cell loss or ductal metaplasia compared with similarly treated wild-type mice   (MGI Ref ID J:76811)
    • following pancreatic duct ligation, mice fail to exhibit any increase in acinar cell apoptosis unlike in similarly treated wild-type mice   (MGI Ref ID J:76811)
    • however, mice subjected to pancreatic duct ligation exhibit local chronic pancreatitis immediately adjacent to the cut   (MGI Ref ID J:76811)

Mmp7tm1Lmm/Mmp7tm1Lmm

        involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ
  • immune system phenotype
  • abnormal macrophage physiology
    • macrophages fail to resorb co-cultured intervertebral discs unlike wild-type cells that reduce disc weight by 39%   (MGI Ref ID J:124841)
    • however, macrophage migration and chemotaxis are normal   (MGI Ref ID J:124841)
    • impaired macrophage chemotaxis
      • macrophage infiltration into co-cultured intervertebral discs is absent in the transitional zone and 96% reduced in the annulus fibrosus unlike wild-type macrophages   (MGI Ref ID J:124841)
  • decreased tumor necrosis factor secretion
    • macrophages co-cultured with intervertebral discs produce less than 2% of the soluble TNF-alpha produced by similarly treated wild-type cells   (MGI Ref ID J:124841)
  • cellular phenotype
  • impaired macrophage chemotaxis
    • macrophage infiltration into co-cultured intervertebral discs is absent in the transitional zone and 96% reduced in the annulus fibrosus unlike wild-type macrophages   (MGI Ref ID J:124841)
  • hematopoietic system phenotype
  • abnormal macrophage physiology
    • macrophages fail to resorb co-cultured intervertebral discs unlike wild-type cells that reduce disc weight by 39%   (MGI Ref ID J:124841)
    • however, macrophage migration and chemotaxis are normal   (MGI Ref ID J:124841)
    • impaired macrophage chemotaxis
      • macrophage infiltration into co-cultured intervertebral discs is absent in the transitional zone and 96% reduced in the annulus fibrosus unlike wild-type macrophages   (MGI Ref ID J:124841)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Immunology, Inflammation and Autoimmunity Research
Inflammation
      Neutrophil defects

Internal/Organ Research
Wound Healing
      delayed/impaired

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Mmp7tm1Lmm
Allele Name targeted mutation 1, Lynn M Matrisian
Allele Type Targeted (Null/Knockout)
Common Name(s) MAT-; MMP7-; Mmp7tm1vu; mmp-7-;
Mutation Made By Carole Wilson and Lynn Matrisian,   Univ. Washington School of Medicine
Strain of Origin(129X1/SvJ x 129S1/Sv)F1-Kitl<+>
ES Cell Line NameR1
ES Cell Line Strain(129X1/SvJ x 129S1/Sv)F1-Kitl<+>
Gene Symbol and Name Mmp7, matrix metallopeptidase 7
Chromosome 9
Gene Common Name(s) MAT; MMP-7; MPMM; MPSL1; PUMP-1; matrilysin;
Molecular Note A neomycin resistance cassette replaced approximately 95 nucleotides of coding sequence in exon 4 of the gene. No transcript for the targeted gene was detectable by Northern blot analysis of RNA from the small intestine of homozygous mutant mice. [MGI Ref ID J:38609]

Genotyping

Genotyping Information

Genotyping Protocols

Mmp7tm1Lmm, Separated PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Wilson CL; Heppner KJ; Labosky PA; Hogan BL; Matrisian LM. 1997. Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin. Proc Natl Acad Sci U S A 94(4):1402-7. [PubMed: 9037065]  [MGI Ref ID J:38609]

Additional References

Li Q; Park PW; Wilson CL; Parks WC. 2002. Matrilysin shedding of syndecan-1 regulates chemokine mobilization and transepithelial efflux of neutrophils in acute lung injury. Cell 111(5):635-46. [PubMed: 12464176]  [MGI Ref ID J:80692]

Mmp7tm1Lmm related

Acuff HB; Carter KJ; Fingleton B; Gorden DL; Matrisian LM. 2006. Matrix metalloproteinase-9 from bone marrow-derived cells contributes to survival but not growth of tumor cells in the lung microenvironment. Cancer Res 66(1):259-66. [PubMed: 16397239]  [MGI Ref ID J:105098]

Betsuyaku T; Fukuda Y; Parks WC; Shipley JM; Senior RM. 2000. Gelatinase B is required for alveolar bronchiolization after intratracheal bleomycin. Am J Pathol 157(2):525-35. [PubMed: 10934155]  [MGI Ref ID J:108171]

Chen P; Abacherli LE; Nadler ST; Wang Y; Li Q; Parks WC. 2009. MMP7 shedding of syndecan-1 facilitates re-epithelialization by affecting alpha(2)beta(1) integrin activation. PLoS One 4(8):e6565. [PubMed: 19668337]  [MGI Ref ID J:152474]

Chen P; McGuire JK; Hackman RC; Kim KH; Black RA; Poindexter K; Yan W; Liu P; Chen AJ; Parks WC; Madtes DK. 2008. Tissue inhibitor of metalloproteinase-1 moderates airway re-epithelialization by regulating matrilysin activity. Am J Pathol 172(5):1256-70. [PubMed: 18385523]  [MGI Ref ID J:134273]

Crawford HC; Scoggins CR; Washington MK; Matrisian LM; Leach SD. 2002. Matrix metalloproteinase-7 is expressed by pancreatic cancer precursors and regulates acinar-to-ductal metaplasia in exocrine pancreas. J Clin Invest 109(11):1437-44. [PubMed: 12045257]  [MGI Ref ID J:76811]

Dunsmore SE; Saarialho-Kere UK; Roby JD; Wilson CL; Matrisian LM; Welgus HG; Parks WC. 1998. Matrilysin expression and function in airway epithelium. J Clin Invest 102(7):1321-31. [PubMed: 9769324]  [MGI Ref ID J:115243]

Foureau DM; Mielcarz DW; Menard LC; Schulthess J; Werts C; Vasseur V; Ryffel B; Kasper LH; Buzoni-Gatel D. 2010. TLR9-dependent induction of intestinal alpha-defensins by Toxoplasma gondii. J Immunol 184(12):7022-9. [PubMed: 20488791]  [MGI Ref ID J:161130]

Fukuda A; Wang SC; Morris JP 4th; Folias AE; Liou A; Kim GE; Akira S; Boucher KM; Firpo MA; Mulvihill SJ; Hebrok M. 2011. Stat3 and MMP7 Contribute to Pancreatic Ductal Adenocarcinoma Initiation and Progression. Cancer Cell 19(4):441-55. [PubMed: 21481787]  [MGI Ref ID J:170982]

Gharib SA; Altemeier WA; Van Winkle LS; Plopper CG; Schlesinger SY; Buell CA; Brauer R; Lee V; Parks WC; Chen P. 2013. Matrix metalloproteinase-7 coordinates airway epithelial injury response and differentiation of ciliated cells. Am J Respir Cell Mol Biol 48(3):390-6. [PubMed: 23258229]  [MGI Ref ID J:208739]

Goswami S; Angkasekwinai P; Shan M; Greenlee KJ; Barranco WT; Polikepahad S; Seryshev A; Song LZ; Redding D; Singh B; Sur S; Woodruff P; Dong C; Corry DB; Kheradmand F. 2009. Divergent functions for airway epithelial matrix metalloproteinase 7 and retinoic acid in experimental asthma. Nat Immunol 10(5):496-503. [PubMed: 19329997]  [MGI Ref ID J:148285]

Guillen-Ahlers H; Buechler SA; Suckow MA; Castellino FJ; Ploplis VA. 2008. Sulindac treatment alters collagen and matrilysin expression in adenomas of ApcMin/+ mice. Carcinogenesis 29(7):1421-7. [PubMed: 18499699]  [MGI Ref ID J:139063]

Haro H; Crawford HC; Fingleton B; Shinomiya K; Spengler DM; Matrisian LM. 2000. Matrix metalloproteinase-7-dependent release of tumor necrosis factor-alpha in a model of herniated disc resorption. J Clin Invest 105(2):143-50. [PubMed: 10642592]  [MGI Ref ID J:124841]

Hu BH; Cai Q; Hu Z; Patel M; Bard J; Jamison J; Coling D. 2012. Metalloproteinases and their associated genes contribute to the functional integrity and noise-induced damage in the cochlear sensory epithelium. J Neurosci 32(43):14927-41. [PubMed: 23100416]  [MGI Ref ID J:191223]

Hulboy DL; Gautam S; Fingleton B; Matrisian LM. 2004. The influence of matrix metalloproteinase-7 on early mammary tumorigenesis in the multiple intestinal neoplasia mouse. Oncol Rep 12(1):13-7. [PubMed: 15201952]  [MGI Ref ID J:91647]

Kassim SY; Gharib SA; Mecham BH; Birkland TP; Parks WC; McGuire JK. 2007. Individual matrix metalloproteinases control distinct transcriptional responses in airway epithelial cells infected with Pseudomonas aeruginosa. Infect Immun 75(12):5640-50. [PubMed: 17923522]  [MGI Ref ID J:153651]

Kitamura T; Biyajima K; Aoki M; Oshima M; Taketo MM. 2009. Matrix metalloproteinase 7 is required for tumor formation, but dispensable for invasion and fibrosis in SMAD4-deficient intestinal adenocarcinomas. Lab Invest 89(1):98-105. [PubMed: 19002110]  [MGI Ref ID J:142797]

Kitamura T; Fujishita T; Loetscher P; Revesz L; Hashida H; Kizaka-Kondoh S; Aoki M; Taketo MM. 2010. Inactivation of chemokine (C-C motif) receptor 1 (CCR1) suppresses colon cancer liver metastasis by blocking accumulation of immature myeloid cells in a mouse model. Proc Natl Acad Sci U S A 107(29):13063-8. [PubMed: 20616008]  [MGI Ref ID J:162411]

Kure T; Chang JH; Kato T; Hernandez-Quintela E; Ye H; Lu PC; Matrisian LM; Gatinel D; Shapiro S; Gosheh F; Azar DT. 2003. Corneal neovascularization after excimer keratectomy wounds in matrilysin-deficient mice. Invest Ophthalmol Vis Sci 44(1):137-44. [PubMed: 12506066]  [MGI Ref ID J:119224]

Lee MM; Yoon BJ; Osiewicz K; Preston M; Bundy B; van Heeckeren AM; Werb Z; Soloway PD. 2005. Tissue inhibitor of metalloproteinase 1 regulates resistance to infection. Infect Immun 73(1):661-5. [PubMed: 15618213]  [MGI Ref ID J:94836]

Li Q; Park PW; Wilson CL; Parks WC. 2002. Matrilysin shedding of syndecan-1 regulates chemokine mobilization and transepithelial efflux of neutrophils in acute lung injury. Cell 111(5):635-46. [PubMed: 12464176]  [MGI Ref ID J:80692]

Lindsey ML; Escobar GP; Mukherjee R; Goshorn DK; Sheats NJ; Bruce JA; Mains IM; Hendrick JK; Hewett KW; Gourdie RG; Matrisian LM; Spinale FG. 2006. Matrix metalloproteinase-7 affects connexin-43 levels, electrical conduction, and survival after myocardial infarction. Circulation 113(25):2919-28. [PubMed: 16769909]  [MGI Ref ID J:122893]

Littlepage LE; Sternlicht MD; Rougier N; Phillips J; Gallo E; Yu Y; Williams K; Brenot A; Gordon JI; Werb Z. 2010. Matrix metalloproteinases contribute distinct roles in neuroendocrine prostate carcinogenesis, metastasis, and angiogenesis progression. Cancer Res 70(6):2224-34. [PubMed: 20215503]  [MGI Ref ID J:157977]

Manicone AM; Huizar I; McGuire JK. 2009. Matrilysin (Matrix Metalloproteinase-7) regulates anti-inflammatory and antifibrotic pulmonary dendritic cells that express CD103 (alpha(E)beta(7)-integrin). Am J Pathol 175(6):2319-31. [PubMed: 19893044]  [MGI Ref ID J:155322]

Martin MD; Carter KJ; Jean-Philippe SR; Chang M; Mobashery S; Thiolloy S; Lynch CC; Matrisian LM; Fingleton B. 2008. Effect of ablation or inhibition of stromal matrix metalloproteinase-9 on lung metastasis in a breast cancer model is dependent on genetic background. Cancer Res 68(15):6251-9. [PubMed: 18676849]  [MGI Ref ID J:140033]

Ogden SR; Noto JM; Allen SS; Patel DA; Romero-Gallo J; Washington MK; Fingleton B; Israel DA; Lewis ND; Wilson KT; Chaturvedi R; Zhao Z; Shyr Y; Peek RM Jr. 2010. Matrix metalloproteinase-7 and premalignant host responses in Helicobacter pylori-infected mice. Cancer Res 70(1):30-5. [PubMed: 20048070]  [MGI Ref ID J:155734]

Pal S; Schmidt AP; Peterson EM; Wilson CL; de la Maza LM. 2006. Role of matrix metalloproteinase-7 in the modulation of a Chlamydia trachomatis infection. Immunology 117(2):213-9. [PubMed: 16423057]  [MGI Ref ID J:106779]

Reil JC; Gilles S; Zahler S; Brandl A; Drexler H; Hultner L; Matrisian LM; Welsch U; Becker BF. 2007. Insights from knock-out models concerning postischemic release of TNFalpha from isolated mouse hearts. J Mol Cell Cardiol 42(1):133-41. [PubMed: 17101148]  [MGI Ref ID J:119661]

Rudolph-Owen LA; Hulboy DL; Wilson CL; Mudgett J; Matrisian LM. 1997. Coordinate expression of matrix metalloproteinase family members in the uterus of normal, matrilysin-deficient, and stromelysin-1-deficient mice. Endocrinology 138(11):4902-11. [PubMed: 9348221]  [MGI Ref ID J:43855]

Salzman NH; Hung K; Haribhai D; Chu H; Karlsson-Sjoberg J; Amir E; Teggatz P; Barman M; Hayward M; Eastwood D; Stoel M; Zhou Y; Sodergren E; Weinstock GM; Bevins CL; Williams CB; Bos NA. 2010. Enteric defensins are essential regulators of intestinal microbial ecology. Nat Immunol 11(1):76-83. [PubMed: 19855381]  [MGI Ref ID J:157881]

Shi J; Aono S; Lu W; Ouellette AJ; Hu X; Ji Y; Wang L; Lenz S; van Ginkel FW; Liles M; Dykstra C; Morrison EE; Elson CO. 2007. A novel role for defensins in intestinal homeostasis: regulation of IL-1beta secretion. J Immunol 179(2):1245-53. [PubMed: 17617617]  [MGI Ref ID J:149388]

Swee M; Wilson CL; Wang Y; McGuire JK; Parks WC. 2008. Matrix metalloproteinase-7 (matrilysin) controls neutrophil egress by generating chemokine gradients. J Leukoc Biol 83(6):1404-12. [PubMed: 18334539]  [MGI Ref ID J:136866]

Takahashi N; Vanlaere I; de Rycke R; Cauwels A; Joosten LA; Lubberts E; van den Berg WB; Libert C. 2008. IL-17 produced by Paneth cells drives TNF-induced shock. J Exp Med 205(8):1755-61. [PubMed: 18663129]  [MGI Ref ID J:139519]

Thiolloy S; Halpern J; Holt GE; Schwartz HS; Mundy GR; Matrisian LM; Lynch CC. 2009. Osteoclast-derived matrix metalloproteinase-7, but not matrix metalloproteinase-9, contributes to tumor-induced osteolysis. Cancer Res 69(16):6747-55. [PubMed: 19679556]  [MGI Ref ID J:151928]

Wang M; Qin X; Mudgett JS; Ferguson TA; Senior RM; Welgus HG. 1999. Matrix metalloproteinase deficiencies affect contact hypersensitivity: stromelysin-1 deficiency prevents the response and gelatinase B deficiency prolongs the response. Proc Natl Acad Sci U S A 96(12):6885-9. [PubMed: 10359808]  [MGI Ref ID J:55723]

Wang X; Chow FL; Oka T; Hao L; Lopez-Campistrous A; Kelly S; Cooper S; Odenbach J; Finegan BA; Schulz R; Kassiri Z; Lopaschuk GD; Fernandez-Patron C. 2009. Matrix metalloproteinase-7 and ADAM-12 (a disintegrin and metalloproteinase-12) define a signaling axis in agonist-induced hypertension and cardiac hypertrophy. Circulation 119(18):2480-9. [PubMed: 19398663]  [MGI Ref ID J:166429]

Wang XY; Demelash A; Kim H; Jensen-Taubman S; Dakir el H; Ozbun L; Birrer MJ; Linnoila RI. 2009. Matrilysin-1 mediates bronchiolization of alveoli, a potential premalignant change in lung cancer. Am J Pathol 175(2):592-604. [PubMed: 19608871]  [MGI Ref ID J:150778]

Xu J; Park PW; Kheradmand F; Corry DB. 2005. Endogenous attenuation of allergic lung inflammation by syndecan-1. J Immunol 174(9):5758-65. [PubMed: 15843578]  [MGI Ref ID J:98401]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX11

Colony Maintenance

Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $199.90Female or MaleHomozygous for Mmp7tm1Lmm  
Price per Pair (US dollars $)Pair Genotype
$399.80Homozygous for Mmp7tm1Lmm x Homozygous for Mmp7tm1Lmm  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $259.90Female or MaleHomozygous for Mmp7tm1Lmm  
Price per Pair (US dollars $)Pair Genotype
$519.80Homozygous for Mmp7tm1Lmm x Homozygous for Mmp7tm1Lmm  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

  Control
   000664 C57BL/6J (approximate)
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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Terms of Use


General Terms and Conditions


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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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