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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Type Coisogenic; Mutant Strain; Spontaneous Mutation; Additional information on Genetically Engineered Mutant Mice. Species laboratory mouse Generation F243+F3+N1F16 (07-DEC-07) Description
Mice homozygous for the ctl mutation are easily recognizable at birth by their curly or bent tails.Development
The ctl mutation arose spontaneously on the A/WySnJ background at The Jackson Laboratory when that strain was at F243. It has been maintained primarily through sibling breeding with one backcross to A/WySnJ. In 2004 this strain reached generation F243+F3+N1F7.
Control Information
| Control | ||
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| Heterozygote from the colony | ||
| Considerations for Choosing Controls | ||
Phenotype
Phenotype Information
View Mammalian Phenotype Terms
Mammalian Phenotype Terms
assigned by genotype
ctl/ctl
A/WySnJ-ctl/J
- hearing/vestibular/ear phenotype
- *normal* hearing/vestibular/ear phenotype (MGI Ref ID J:91389)
- hearing of 2 homozygous mutant mice was normal at 6 weeks of age as determined by acoustic brainstem response (ABR)
- immune system phenotype
- arthritis (MGI Ref ID J:91389)
- mild spinal arthritis was detected at 3 months by pathology screen
- limbs/digits/tail phenotype
- abnormal caudal vertebrae morphology (MGI Ref ID J:91389)
- tail vertebrae are abnormally shaped, causing the tail to curl or kink; skeleton appeared otherwise normal on X-ray images
- curly tail (MGI Ref ID J:91389)
- incompletely penetrant: matings of ctl/ctl to ctl/+ mice yielded 26% affected progeny, indicating approximately 50% penetrance in this background
- skeleton phenotype
- abnormal caudal vertebrae morphology (MGI Ref ID J:91389)
- tail vertebrae are abnormally shaped, causing the tail to curl or kink; skeleton appeared otherwise normal on X-ray images
- arthritis (MGI Ref ID J:91389)
- mild spinal arthritis was detected at 3 months by pathology screen
- vision/eye phenotype
- *normal* vision/eye phenotype (MGI Ref ID J:91389)
- eyes of homozygous mutant mice examined ophthalmoscopically at 6 weeks and 3 months of age appeared normal
- nervous system phenotype
- hydroencephaly (MGI Ref ID J:91389)
- mild: detected at 3 months by pathology screen; not associated with cerebellar abnormality in liveborn mice
This mouse can be used to support research in many areas including:ctl related
Developmental Biology Research
Neural Tube Defects
Skeletal Defects
Neurobiology Research
Neural Tube Defects
Genes & Alleles
Gene & Allele Information
| Allele Symbol | ctl | ||
|---|---|---|---|
| Allele Name | curly tail-like | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | A/WySnJ | ||
| General Note | In the homozygous state, this mutation causes a phenotype similar to that of ct, curly tail; both show low penetrance and map to approximately the same region of Chr 4. A complementation test between mice homozygous for ct and for ctl yielded no affectedmice among 56 progeny, but because of the low penetrance of the phenotype, this does not rule out their being allelic. | ||
| Molecular Note | This spontaneous mutation arose at The Jackson Laboratory. | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Optimizing PCR Protocols
References
References
Selected Reference(s)
Original article from The Mouse Mutant ResourceHarris BS; Ward-Bailey PF; Bronson RT; Donahue LR; Davisson MT. 2004. Curly tail-like: a new mutation on Mouse Chromosome 4. Mouse Mutant Resources Web Site, The Jackson Laboratory, Bar Harbor, Maine (http://www.jax.org/mmr) MGI Direct Data Submission :. [MGI Ref ID J:91389]
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Weeks of Age Price* Gender Genotypes Provided Individual Mouse Price $127.90 Female or Male Homozygous for ctl *Price(s) in US dollars ($)
Pairs /Price* Pair Genotype $255.80 Heterozygous for ctl x Homozygous for ctl $255.80 Homozygous for ctl x Heterozygous for ctl
Additional Supply Details
| Supply Notes |
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| Pricing for International shipping destinations |
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Weeks of Age Price* Gender Genotypes Provided Individual Mouse Price $166.30 Female or Male Homozygous for ctl *Price(s) in US dollars ($)
Pairs /Price* Pair Genotype $332.60 Heterozygous for ctl x Homozygous for ctl $332.60 Homozygous for ctl x Heterozygous for ctl
Additional Supply Details
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement. |
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Control Information
| Control | ||
|---|---|---|
| Heterozygote from the colony | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
General Terms and Conditions
See Terms of Use
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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Contact information
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| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
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