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Strain Name:

B6.D2-(D9Mit329-D9Mit115)/LusJ

Stock Number:

005175

Availability:

Under Development for Cryopreservation Repository

To register your interest in this strain go to the Strain Interest Form.
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Additional Licensing and Use Restrictions

Former Name      B6.D2-Chr9M/LusJ    (Changed: 12-JUL-05 )
Genes & Alleles   D9Mit115;   D9Mit329;   ;

Product Information

Strain Details

Type JAX® GEMM® Strain - Congenic
Additional information on JAX® GEMM® Strains.
Specieslaboratory mouse
Background Strain C57BL/6J
Donor Strain DBA/2J
H2 Haplotypeb
GenerationN?+F3 (18-DEC-07)

Appearance
nonagouti dilute (dark grey)
Related Genotype: a/a Myo5ad/Myo5ad

Strain Description
This C57BL/6J congenic carries the middle portion of Chromosome 9 from DBA/2J. The Mit or SNP (rs) markers in the strain name define the congenic interval.

Marker-assisted breeding was used to construct a set of overlapping congenic strains called genome-tagged mice (GTM) that span the entire mouse genome. Each member of the panel carries an average of a 23 cM segment (range eight to 58 cM) from DBA/2J introgressed on to a C57BL/6J background. The segments represent the distal (D), middle (M), and proximal (P) portions of all or most of a given chromosome. (Iakoubova et al. 2001) GTM are a valuable resource for mapping and confirmation of loci contributing to complex traits.

The Jackson Laboratory is working with Dr. Lusis' group to import and make available additional strains in the panel.

Strain Development
This congenic panel was initiated by a cross of B6D2F1/J (Stock #100006) females to C57BL/6J males. Male progeny at each generation were selected by marker assisted genome scan and were backcrossed to C57BL/6J females to produce the N3-N6 generations. All animals in the panel carry a C57BL/6J Y chromosome. Sibling pairs at the N6 generation were intercrossed to produce homozygotes. Iakoubova OA, et. al. provides a more detailed explanation of the chromosome intervals. Dr. Lusis donated the panel to The Jackson Laboratory in 2004.

Gene & Allele Details

Gene Symbol and Name D9Mit115, DNA segment, Chr 9, Massachusetts Institute of Technology 115
Chromosome 9
Gene Symbol and Name D9Mit329, DNA Segment, Chr 9 Massachusetts Institute of Technology 329
Chromosome 9

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Colony Maintenance

Diet Information LabDiet® 5K52/5K67

Related Strains

View Other Related Strains     (12 strains)

Additional Web Information

Congenic Nomenclature

Research Applications

This mouse can be used to support research in many areas including:

Research Tools
Genetics Research (Gene Mapping: Tools for QTL Mapping, Segregation and Linkage Analysis)

References

Selected Reference(s)

Davis RC; Schadt EE; Smith DJ; Hsieh EW; Cervino AC; van Nas A; Rosales M; Doss S; Meng H; Allayee H; Lusis AJ. 2005. A genome-wide set of congenic mouse strains derived from DBA/2J on a C57BL/6J background. Genomics 86(3):259-70. [PubMed: 16039824]  [MGI Ref ID J:107521]

Iakoubova OA; Olsson CL; Dains KM; Ross DA; Andalibi A; Lau K; Choi J; Kalcheva I; Cunanan M; Louie J; Nimon V; Machrus M; Bentley LG; Beauheim C; Silvey S; Cavalcoli J; Lusis AJ; West DB. 2001. Genome-tagged mice (GTM): two sets of genome-wide congenic strains. Genomics 74(1):89-104. [PubMed: 11374905]  [MGI Ref ID J:69881]

Price and Supply Information

Strain Name: B6.D2-(D9Mit329-D9Mit115)/LusJ
Stock Number: 005175
 

This strain is currently Under Development for Cryopreservation Repository.
To register your interest in this strain go to the Strain Interest Form.

Estimated Available for Sale Date:

Please note: Estimated available for sale dates are provided to keep customers better informed on strains under development. Please note that our Colony Managers routinely monitor the target date and edit it based on breeding performance and other factors. The length of time it takes to make a new strain available for sale depends on genotype, age, number of animals sent by the Donating Investigator, breeding performance, additional strain development (backcrossing, making homozygous), and anticipated demand for the strain/interest registered.

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Supply Details

Standard SupplyUnder Development for Cryopreservation Repository
Supply Notes This strain is included in the Mouse Mutant Resource collection.
Supply Notes Genomic DNA is available for this strain from the Mouse DNA Resource.
LicensingSee General Terms and Conditions below for Licensing and Use Restrictions  
Control InformationView Control Information in Strain Details.

General Terms and Conditions

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For additional Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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