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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Type Coisogenic; Mutant Strain; Spontaneous Mutation; Additional information on Genetically Engineered Mutant Mice. Mating System Cross-Intercross (Female x Male) homozygote x +/? sibling then heterozygote x heterozygote Species laboratory mouse Generation F208+F8 (07-NOV-05)
Control Information
| Control | ||
|---|---|---|
| +/? from the colony | ||
| Heterozygote from the colony | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of Mbp
002492 B6.MDB-Mbpshi-mld/J 001428 C3Fe.SWV-Mbpshi/J 004223 CHa.SWV(C3Fe)-Mbpshi/J View Strains carrying other alleles of Mbp (3 strains)
Additional Web Information
Genetic Quality Control Annual Report
Phenotype
Phenotype Information
assigned by genotype
Mbpshi-J/Mbpshi-J
BALB/cJ-Mbpshi-J/J
- nervous system phenotype
- abnormal myelin sheath morphology (MGI Ref ID J:117543)
- abnormal myelination (MGI Ref ID J:117543)
- lack of central nervous system myelin
- behavior/neurological phenotype
- ataxia (MGI Ref ID J:117543)
- tremors (MGI Ref ID J:117543)
- general tremor during locomotion visible by 12 days of age
- hearing/vestibular/ear phenotype
- decreased brainstem auditory evoked potential (MGI Ref ID J:117543)
- ABR shows 10 to 20 dB elevation of thresholds and abnormal wave patterns with long interpeak latencies at 2.5 months of age
- vision/eye phenotype
- *normal* vision/eye phenotype (MGI Ref ID J:117543)
- normal vision by ERG
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Mbpshi-J | ||
|---|---|---|---|
| Allele Name | shiverer Jackson | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | BALB/cJ | ||
| Gene Symbol and Name | Mbp, myelin basic protein | ||
| Chromosome | 18 | ||
| Gene Common Name(s) | C76307; Hmbpr; MGC99675; R75289; expressed sequence C76307; expressed sequence R75289; golli-mbp; hemopoietic myelin basic protein related; mld; myelin deficient; shi; shiverer; | ||
| Molecular Note | This spontaneous mutation was shown to be an allele of the myelin basic protein gene by its failure to complement the original shiverer mutation. | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Optimizing PCR Protocols
References
References
Additional References
Mbpshi-J relatedThompson DA; Ward-Bailey PF; Donahue LR; Bronson RT; Davisson MT. 2007. A remutation to Mbp<shi> named shiverer Jackson (shiJ) MGI Direct Data Submission :. [MGI Ref ID J:117543]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number A2A
Colony Maintenance
Mating System Cross-Intercross (Female x Male) homozygote x +/? sibling then heterozygote x heterozygote
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Weeks of Age Price* Gender Genotypes Provided Individual Mouse Price $126.00 Female or Male Heterozygous for Mbpshi-J $199.30 Female or Male Homozygous for Mbpshi-J *Price(s) in US dollars ($)
Pairs /Price* Pair Genotype $252.00 Heterozygous for Mbpshi-J x Heterozygous for Mbpshi-J
Additional Supply Details
| Supply Notes |
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| Pricing for International shipping destinations |
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Weeks of Age Price* Gender Genotypes Provided Individual Mouse Price $163.80 Female or Male Heterozygous for Mbpshi-J $259.10 Female or Male Homozygous for Mbpshi-J *Price(s) in US dollars ($)
Pairs /Price* Pair Genotype $327.60 Heterozygous for Mbpshi-J x Heterozygous for Mbpshi-J
Additional Supply Details
| Supply Notes |
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement. |
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| Supply Notes |
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Control Information
| Control | ||
|---|---|---|
| +/? from the colony | ||
| Heterozygote from the colony | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
General Terms and Conditions
See Terms of Use
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
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Terms of Use
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General Terms and Conditions
Contact information
General inquiries
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| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice & Services Conditions of Use
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