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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Type Mutant Stock; Spontaneous Mutation; Additional information on Genetically Engineered Mutant Mice. Mating System Ovarian Transplant-Cross-Intercross (Female x Male) homozygous ovarian transplant host x C57BL/6J then obligate heterozygous offspring are intercrossed Species laboratory mouse Generation F250+F1+N4 (07-MAY-08) Development
The reeler 4 Jackson mutation arose spontaneously in the B6.129S2-Irf1tm1Mak/J strain (Stock No. 002762) at The Jackson Laboratory. This mutation has been maintained via ovarian transplant backcross-intercross to C57BL/6J and the targeted mutation has been bred out of this strain.
Control Information
| Control | ||
|---|---|---|
| +/? from the colony | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of Reln
000235 B6C3Fe a/a-Relnrl/J 005744 C57BL/6J-Relnrl-6J/J 007892 C57BL/6J-Relnrl-7J/J View Strains carrying other alleles of Reln (3 strains)
Phenotype
Phenotype Information
assigned by genotype
Relnrl-4J/Relnrl-4J
B6;129S2-Relnrl-4J/J
- nervous system phenotype
- abnormal cerebellar cortex morphology (MGI Ref ID J:133649)
- scrambled layering in the cortex with neurons of the hippocampal gyrus scattered in an irregular wavy layer and the cerebellum is smaller with scrambled Purkinje and granule cells
- abnormal cerebellar Purkinje cell layer (MGI Ref ID J:133649)
- abnormal cerebellar granule layer (MGI Ref ID J:133649)
- abnormal stratification in cerebral cortex (MGI Ref ID J:133649)
- small cerebellum (MGI Ref ID J:133649)
- behavior/neurological phenotype
- abnormal gait (MGI Ref ID J:133649)
- ataxia (MGI Ref ID J:133649)
- locomotion is impaired by 2 weeks of age, with a leaning side-to-side as they walk and falling onto their sides
- impaired balance (MGI Ref ID J:133649)
- life span-post-weaning/aging
- premature death (MGI Ref ID J:133649)
- some die by wean age
- growth/size phenotype
- decreased body size (MGI Ref ID J:133649)
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Relnrl-4J | ||
|---|---|---|---|
| Allele Name | reeler 4 Jackson | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | B6.129S2-Irf1tm1Mak/J | ||
| Gene Symbol and Name | Reln, reelin | ||
| Chromosome | 5 | ||
| Gene Common Name(s) | PRO1598; RL; Reelen; reeler; rl; | ||
| Molecular Note | Non-complementation with the original reeler mutation suggests that these two mutations are alleles of the same gene. | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Optimizing PCR Protocols
References
References
Selected Reference(s)
Marden CC; Ward-Bailey PF; Bronson RT; Johnson KR. 2008. Reeler 4 Jackson (Reln
, a remutation of the Reln gene with more severe lethality MGI Direct Data Submission :. [MGI Ref ID J:133649]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number A1
Colony Maintenance
Mating System Ovarian Transplant-Cross-Intercross (Female x Male) homozygous ovarian transplant host x C57BL/6J then obligate heterozygous offspring are intercrossed
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
|
Weeks of Age Price* Gender Genotypes Provided Individual Mouse Price $197.70 Female or Male Heterozygous for Relnrl-4J $123.60 Female or Male Heterozygous or Wild-type for Relnrl-4J - +/? *Price(s) in US dollars ($)
Pairs /Price* Pair Genotype $395.40 Heterozygous for Relnrl-4J x Heterozygous for Relnrl-4J
Additional Supply Details
| Supply Notes |
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| Pricing for International shipping destinations |
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Weeks of Age Price* Gender Genotypes Provided Individual Mouse Price $257.10 Female or Male Heterozygous for Relnrl-4J $160.70 Female or Male Heterozygous or Wild-type for Relnrl-4J - +/? *Price(s) in US dollars ($)
Pairs /Price* Pair Genotype $514.10 Heterozygous for Relnrl-4J x Heterozygous for Relnrl-4J
Additional Supply Details
| Supply Notes |
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement. |
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| Supply Notes |
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Control Information
| Control | ||
|---|---|---|
| +/? from the colony | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
General Terms and Conditions
See Terms of Use
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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Terms of Use
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Contact information
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| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
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