Strain Name:

B6EiC3Sn.BLiA-Ts(1716)65Dn/DnJ

Stock Number:

005252

Order this mouse

Availability:

Repository- Live

Use Restrictions Apply, see Terms of Use
Common Names: B6C3.B-Ts65Dn;     B6EiC3Sn.BLi a/A-Ts65Dn;    
Ts65Dn mice are trisomic for about two-thirds of the genes orthologous to human chromosome 21 and are a model for studying Down Syndrome on a genetic background wild-type for retinal degeneration.

Description

Strain Information

Type Chromosome Aberration; Translocation; Trisomy;
Additional information on Mice with Chromosomal Aberrations.
Type Mutant Stock; Radiation Induced Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Mating SystemTs65Dn trisomic female x B6EiC3Sn.BLiAF1 (003647)
See Colony Maintenance for Ts65Dn for additional details.
Specieslaboratory mouse
 
Donating Investigator Muriel Davisson,   JAX

Description
Segmentally trisomic Ts(1716)65Dn mice provide a postnatal model for Down syndrome. Ts65Dn mice have three copies of most of the genes on mouse Chr 16 that are orthologous to human Chr 21 genes. These extra genes, along with the centromere and about 5% of proximal mouse Chr 17 are contained in a small extra chromosome derived from a reciprocal translocation. See FISH chromosome spreads.

Trisomic mice with the wild-type allele of Pde6b, are similar to the B6EiC3Sn-a/A-Ts(1716)65Dn/J (Stock No. 001924) trisomic mice in that they display slightly shorter body length and lower body weight (see Ts65Dn mouse photograph), show reduced grip strength, nocturnal hyperactivity, and impaired performance in the Morris water maze. Any differences in the Morris water maze tests for the two genetic backgrounds were found to be very subtle. Distinct from Stock No. 001924, this genetic background is homozygous for the wild-type allele of Pde6b and thus all of the trisomic mice generated can be included in experimentation without concern for the impact of retinal degeneration.

The precise locations of the Chr 16 and Chr 17 breakpoints are 84,351,351 bp and 9,426,822 bp, respectively. The Chr 16 segment contains about two thirds of the human Chr 21 homologues in the mouse, from mitochondrial ribosomal protein L39 (Mrpl39) gene to the distal telomere. These data were used to generate a PCR genotyping assay for Ts65Dn (Reinholdt et al., 2011), replacing the previous methods of chromosome analysis or qPCR. For comparison of segments conserved in human Chr 21 with mouse Chrs 16, 17, 10 and genetic definition of Ts65Dn, see the Human - Mouse Orthology Map. Northern and Western blotting, enzyme activity assays and reverse phase protein arrays (RPPA) demonstrate that some but not all genes in the translocation product are expressed at elevated levels in segmentally trisomic animals. RPPA shows a loss of correlation among some brain proteins (Ahmed et al., 2012).

Please see the Down Syndrome and Cytogenetics Models Resource for more information.

Development
The Pde6b+ wild-type allele in the F1 hybrid, B6EiC3Sn.BLiAF1 (Stock No. , 003647) also called B6EiC3Sn.Bli, was utilized to create a Ts65Dn strain without blindness. A Ts65Dn trisomic female from B6EiC3Sn a/A-Ts(1716)65Dn (Stock No. 001924) was crossed to an F1 hybrid male and this was repeated for 5 generations before phenotypic analysis. This strain has been maintained by continuous crossing of a Ts65Dn trisomic female to the 003647 F1 hybrid.

Control Information

  Control
   Wild-type from the colony
   003647 B6EiC3Sn.BLiAF1/J
 
  Considerations for Choosing Controls

Related Strains

View Strains carrying   Pde6b+     (10 strains)

Strains carrying   Ts(1716)65Dn allele
001924   B6EiC3Sn a/A-Ts(1716)65Dn/J
View Strains carrying   Ts(1716)65Dn     (1 strain)

Strains carrying other alleles of Pde6b
004202   B6.C3 Pde6brd1 Hps4le/+ +-Lmx1adr-8J/J
000002   B6.C3-Pde6brd1 Hps4le/J
004297   B6.CXB1-Pde6brd10/J
001022   B6C3FeF1/J a/a
000652   BDP/J
000653   BUB/BnJ
002439   C3.129P2(B6)-B2mtm1Unc/J
005494   C3.129S1(B6)-Grm1rcw/J
000509   C3.Cg-Lystbg-2J/J
000480   C3.MRL-Faslpr/J
001957   C3A Pde6brd1.O20/A-Prph2Rd2/J
004326   C3Bir.129P2(B6)-Il10tm1Cgn/Lt
003968   C3Bir.129P2(B6)-Il10tm1Cgn/LtJ
006435   C3Fe.SW-Soaa/MonJ
001904   C3H-Atcayji-hes/J
000659   C3H/HeJ
000511   C3H/HeJ-Ap3d1mh-2J/J
000784   C3H/HeJ-Faslgld/J
002433   C3H/HeJ-Sptbn4qv-lnd2J/J
005972   C3H/HeJBirLtJ
001824   C3H/HeJSxJ
000635   C3H/HeOuJ
000474   C3H/HeSn
001431   C3H/HeSn-ocd/J
000661   C3H/HeSnJ
002333   C3H/HeSnJ-gri/J
001576   C3He-Atp7btx-J/J
000658   C3HeB/FeJ
002588   C3HeB/FeJ-Eya1bor/J
001533   C3HeB/FeJ-Mc1rE-so Gli3Xt-J/J
001908   C3HfB/BiJ
001502   C3Sn.B6-Epha4rb/EiGrsrJ
002235   C3Sn.C3-Ctnna2cdf/J
001547   C3Sn.Cg-Cm/J
001906   C3fBAnl.Cg-Catb/AnlJ
004766   C57BL/6J-Pde6brd1-2J/J
000656   CBA/J
000813   CBA/J-Atp7aMo-pew/J
000660   DA/HuSnJ
000023   FL/1ReJ
000025   FL/4ReJ
003024   FVB.129P2(B6)-Fmr1tm1Cgr/J
002539   FVB.129P2-Abcb4tm1Bor/J
002935   FVB.129S2(B6)-Ccnd1tm1Wbg/J
002953   FVB.Cg-Tg(MMTVTGFA)254Rjc/J
003170   FVB.Cg-Tg(Myh6-tTA)6Smbf/J
003078   FVB.Cg-Tg(WapIgf1)39Dlr/J
003487   FVB.Cg-Tg(XGFAP-lacZ)3Mes/J
003257   FVB/N-Tg(GFAPGFP)14Mes/J
002856   FVB/N-Tg(TIE2-lacZ)182Sato/J
002384   FVB/N-Tg(UcpDta)1Kz/J
001800   FVB/NJ
001491   FVB/NMob
000804   HPG/BmJ
000734   MOLD/RkJ
000550   MOLF/EiJ
002423   NON/ShiLtJ
000679   P/J
000680   PL/J
000268   RSV/LeJ
000269   SB/LeJ
010968   SB;C3Sn-Lrp4mdig-2J/GrsrJ
005651   SJL.AK-Thy1a/TseJ
000686   SJL/J
000688   ST/bJ
004808   STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
002648   STOCK a/a Cln6nclf/J
000279   STOCK gr +/+ Ap3d1mh/J
005965   STOCK Tg(Pomc1-cre)16Lowl/J
004770   SW.B6-Soab/J
002023   SWR.M-Emv21 Emv22/J
000689   SWR/J
000939   SWR/J-Clcn1adr-mto/J
000692   WB/ReJ KitW/J
100410   WBB6F1/J-KitW/KitW-v/J
000693   WC/ReJ KitlSl/J
View Strains carrying other alleles of Pde6b     (76 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Characteristics of this human disease are associated with transgenes and other mutation types in the mouse.
Down Syndrome
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Ts(1716)65Dn/0

        B6EiC3Sn a/A-Ts(1716)65Dn/J
  • tumorigenesis
  • decreased tumor growth/size
    • transplanted Lewis lung and B16F10 tumor cells exhibit growth suppression with reduced microvessel density compared to tumor cells transplanted into wild-type mice   (MGI Ref ID J:150286)
  • behavior/neurological phenotype
  • abnormal learning/memory/conditioning
    • in 22 degree water there is increased latency of acquisition of the hidden platform in the Morris water maze test   (MGI Ref ID J:153579)
    • abnormal spatial learning   (MGI Ref ID J:153579)
      • physical exercise improves performance of 12-13 month old mutants, but not controls, in the acquisition of the Morris water maze   (MGI Ref ID J:170195)
      • however, physical exercise has no effect on anxiety or depression behaviors in mutants   (MGI Ref ID J:170195)
    • impaired contextual conditioning behavior   (MGI Ref ID J:153579)
    • impaired cued conditioning behavior   (MGI Ref ID J:153579)
  • decreased grip strength
    • output of a grip strength meter shows reduced grip force relative to controls   (MGI Ref ID J:153579)
  • hyperactivity
    • although activity during the light cycle is not different from that of controls, during the dark cycle the total activity is significantly greater than in background controls   (MGI Ref ID J:153579)
  • increased stereotypic behavior
    • significantly increased dark cycle horizontal and vertical stereotypic activity   (MGI Ref ID J:153579)
  • increased vertical activity
    • significantly increased dark cycle rearing   (MGI Ref ID J:153579)
  • growth/size/body phenotype
  • decreased body length
    • the length from the nost to the tip of the tail and the length from the nose to the base of the tail are shorter than in background controls   (MGI Ref ID J:153579)
  • decreased body weight   (MGI Ref ID J:153579)
  • nervous system phenotype
  • abnormal hippocampus morphology
    • mutants exhibit reduced cell proliferation and apoptosis in the hippocampus   (MGI Ref ID J:170195)
    • mutants exhibit a smaller subgranular zone   (MGI Ref ID J:170195)
    • exercise has no effect on the size of subgranular zone   (MGI Ref ID J:170195)
    • abnormal dentate gyrus morphology
      • mutants exhibit a smaller dentate gyrus volume   (MGI Ref ID J:170195)
      • exercise has no effect on the size of dentate gyrus volume   (MGI Ref ID J:170195)
    • abnormal hippocampus granule cell layer
      • mutants exhibit reduced number of granule cells   (MGI Ref ID J:170195)
      • exercise has no effect on the number of granule cells   (MGI Ref ID J:170195)
  • abnormal nervous system development
    • hippocampal neurogenesis is reduced   (MGI Ref ID J:170195)
    • exercise has no effect on hippocampal neurogenesis   (MGI Ref ID J:170195)

Ts(1716)65Dn/0

        B6EiC3Sn.BLiA-Ts(1716)65Dn/DnJ
  • growth/size/body phenotype
  • decreased body length
    • the length from the nost to the tip of the tail is shorter than in background controls, although the length from the nose to the base of the tail does not have a statistically significant difference   (MGI Ref ID J:153579)
  • decreased body weight   (MGI Ref ID J:153579)
  • behavior/neurological phenotype
  • abnormal learning/memory/conditioning
    • in 22 degree water there is increased latency of acquisition of the hidden platform in the Morris water maze test   (MGI Ref ID J:153579)
    • abnormal spatial learning   (MGI Ref ID J:153579)
    • impaired contextual conditioning behavior   (MGI Ref ID J:153579)
    • impaired cued conditioning behavior   (MGI Ref ID J:153579)
  • decreased grip strength
    • output of a grip strength meter shows reduced grip force relative to controls   (MGI Ref ID J:153579)
  • hyperactivity
    • although activity during the light cycle is not different from that of controls, during the dark cycle the total activity is significantly greater than in background controls   (MGI Ref ID J:153579)
  • increased stereotypic behavior
    • significantly increased dark cycle horizontal and vertical stereotypic activity   (MGI Ref ID J:153579)
  • increased vertical activity
    • significantly increased dark cycle rearing   (MGI Ref ID J:153579)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Ts(1716)65Dn/0

        involves: C3H/HeSnJ * C57BL/6JEi * DBA/2J
  • reproductive system phenotype
  • abnormal male germ cell morphology
    • significantly more sperm with head abnormalities   (MGI Ref ID J:117029)
    • oligozoospermia
      • sperm concentration was significantly reduced below controls   (MGI Ref ID J:117029)
  • abnormal sperm motility
    • significantly reduced frequencies of sperm with progressive motility   (MGI Ref ID J:117029)
  • abnormal spermatogenesis   (MGI Ref ID J:117029)
    • spermatocytes beyond pachytene stage and round spermatids are significantly reduced in number, while elongated spermatids are rare and remaining spermatids have deformed nuclei   (MGI Ref ID J:96650)
    • arrest of male meiosis
      • many tubules contain germ cells in arrested at meiotic metaphase 1   (MGI Ref ID J:117029)
    • oligozoospermia
      • sperm concentration was significantly reduced below controls   (MGI Ref ID J:117029)
  • abnormal testis morphology
    • Leydig cells are clustered loosely in expanded interstitial compartment   (MGI Ref ID J:96650)
    • abnormal Sertoli cell morphology
      • only a few Sertoli cells are visible; germ cells appear to be detached from the remaining Sertoli cells   (MGI Ref ID J:96650)
    • decreased testis weight
      • significantly smaller testes than controls   (MGI Ref ID J:117029)
      • testes are 37.9% of control testes weights   (MGI Ref ID J:96650)
  • male infertility
    • presence of an intact extra chromosome interferes with chromosome pairing in meiosis   (MGI Ref ID J:117029)
    • produced no progeny   (MGI Ref ID J:117029)
    • fail to produce a vaginal plug   (MGI Ref ID J:117029)
  • growth/size/body phenotype
  • decreased body size
    • mice are ~20% smaller in size compared to normal littermates postnatally   (MGI Ref ID J:96650)
    • decreased body weight   (MGI Ref ID J:94569)
  • nervous system phenotype
  • abnormal CNS synapse formation
    • the area of presynaptic elements (p38+) is increased in the fascia dentate and motor cortex   (MGI Ref ID J:94569)
    • in young and old mice alike, small presynaptic boutons are decreased and large presynaptic boutons are increased in the fascia dentate and motor cortex with the average diameter of a presynaptic bouton increased by 40% in the cortex   (MGI Ref ID J:94569)
    • 18% of dendritic spines are enlarged and display irregular heads or a globular shape   (MGI Ref ID J:94569)
    • average synapse length is increased 34% in the hippocampus and 25% in the cortex   (MGI Ref ID J:94569)
    • glutamatergic synapses are distributed 33% on the dendritic shaft (compared to 51% in wild-type mice) and 67% (compared to 49% in wild-type mice) on the heads or necks of the dendritic spines   (MGI Ref ID J:94569)
  • abnormal cerebellar granule cell morphology
    • dendritic spine density on granule cells is decreased on average by 17% compared to in wild-type mice   (MGI Ref ID J:94569)
  • abnormal neuron morphology
    • in fascia dentate, spine density is significantly decreased on dendrites of granule cells; dendritic spines are significantly enlarged; dendritic width is similar to controls   (MGI Ref ID J:96650)
    • abnormal dendrite morphology
      • dendritic spine density on granule cells is decreased on average by 17% compared to in wild-type mice   (MGI Ref ID J:94569)
      • 18% of spines are enlarged and display irregular heads or a globular shape   (MGI Ref ID J:94569)
      • basal dentritic spine density in CA1 is increased   (MGI Ref ID J:94569)
  • endocrine/exocrine gland phenotype
  • abnormal testis morphology
    • Leydig cells are clustered loosely in expanded interstitial compartment   (MGI Ref ID J:96650)
    • abnormal Sertoli cell morphology
      • only a few Sertoli cells are visible; germ cells appear to be detached from the remaining Sertoli cells   (MGI Ref ID J:96650)
    • decreased testis weight
      • significantly smaller testes than controls   (MGI Ref ID J:117029)
      • testes are 37.9% of control testes weights   (MGI Ref ID J:96650)

Ts(1716)65Dn/0

        involves: C3H/HeJ * C57BL/6 * DBA/2J
  • nervous system phenotype
  • abnormal cerebellar granule cell morphology
    • granule cell density is reduced to 76% of that in control mice   (MGI Ref ID J:121764)
  • decreased Purkinje cell number
    • Purkinje cell density is reduced to 90% of that in control mice   (MGI Ref ID J:121764)
  • increased brain size   (MGI Ref ID J:121764)
  • small cerebellum
    • cerebellar volume is reduced to 88% of that in control mice   (MGI Ref ID J:121764)
  • behavior/neurological phenotype
  • abnormal spatial learning
    • mice show impairment in a Morris water maze test   (MGI Ref ID J:121764)
  • growth/size/body phenotype
  • decreased body weight   (MGI Ref ID J:121764)

Ts(1716)65Dn/0

        involves: DBA/2J
  • craniofacial phenotype
  • abnormal neurocranium morphology
    • cranial vault is enlarged   (MGI Ref ID J:93223)
  • small cranium
    • size difference was most pronounced along the rostralcaudal axis   (MGI Ref ID J:93223)
  • small mandible
    • mice show a Down's Syndrome-like pattern of mandible reduction   (MGI Ref ID J:93223)
  • limbs/digits/tail phenotype
  • short femur   (MGI Ref ID J:93223)
  • skeleton phenotype
  • abnormal neurocranium morphology
    • cranial vault is enlarged   (MGI Ref ID J:93223)
  • short femur   (MGI Ref ID J:93223)
  • small cranium
    • size difference was most pronounced along the rostralcaudal axis   (MGI Ref ID J:93223)
  • small mandible
    • mice show a Down's Syndrome-like pattern of mandible reduction   (MGI Ref ID J:93223)

Ts(1716)65Dn/0

        involves: C3H * C57BL/6 * DBA/2J
  • craniofacial phenotype
  • abnormal incisor morphology
    • mice exhibit a reduction in the height of the incisive alveolar segment compared to in wild-type mice   (MGI Ref ID J:73800)
  • abnormal mandibular angle morphology
    • reduced in size compared to in wild-type mice   (MGI Ref ID J:73800)
  • abnormal mandibular coronoid process morphology
    • reduced in size compared to in wild-type mice   (MGI Ref ID J:73800)
  • decreased cranium height
    • mice exhibit a more generalized shortening of the skull along the anterior posterior axis compared to in Ts(1216)1Cje mice   (MGI Ref ID J:73800)
  • small mandible   (MGI Ref ID J:73800)
  • skeleton phenotype
  • abnormal mandibular angle morphology
    • reduced in size compared to in wild-type mice   (MGI Ref ID J:73800)
  • abnormal mandibular coronoid process morphology
    • reduced in size compared to in wild-type mice   (MGI Ref ID J:73800)
  • decreased cranium height
    • mice exhibit a more generalized shortening of the skull along the anterior posterior axis compared to in Ts(1216)1Cje mice   (MGI Ref ID J:73800)
  • small mandible   (MGI Ref ID J:73800)

Ts(1716)65Dn/0

        involves: C3H/HeJ * C57BL/6JEi * DBA/2J
  • nervous system phenotype
  • abnormal Purkinje cell morphology
    • Purkinje cell linear density is decreased compared to in wild-type mice   (MGI Ref ID J:91221)

Ts(1716)65Dn/0

        involves: C3H/HeJ * C57BL/6J * DBA/2J
  • tumorigenesis
  • increased lymphoma incidence
    • malignant lymphoma in the spleen and lymph nodes is observed in some mutants   (MGI Ref ID J:174270)
    • megakaryocytes are numerous is some spleens, suggesting a relation to megakaryocytic leukemia   (MGI Ref ID J:174270)
    • increased follicular lymphoma incidence
      • splenic architecture is replaced by proliferated immature mononuclear cells arranged in follicular aggregates indicating follicular lymphoma   (MGI Ref ID J:174270)
  • increased malignant tumor incidence
    • some mutants exhibit malignant tumors of liver, colon, or lung   (MGI Ref ID J:174270)
  • immune system phenotype
  • abnormal spleen B cell follicle morphology
    • splenic white pulp contains follicles that are larger and more irregular in shape than normal follicles and are often fused with adjacent follicles   (MGI Ref ID J:174270)
  • abnormal spleen red pulp morphology
    • splenic red pulp is largely obliterated   (MGI Ref ID J:174270)
  • hematopoietic system phenotype
  • abnormal spleen B cell follicle morphology
    • splenic white pulp contains follicles that are larger and more irregular in shape than normal follicles and are often fused with adjacent follicles   (MGI Ref ID J:174270)
  • abnormal spleen red pulp morphology
    • splenic red pulp is largely obliterated   (MGI Ref ID J:174270)

Ts(1716)65Dn/0

        involves: C3H/HeH * C3H/HeSn * C57BL/6Ei * C57BL/6J * DBA/2J
  • mortality/aging
  • partial postnatal lethality   (MGI Ref ID J:185269)
  • cardiovascular system phenotype
  • abnormal heart electrocardiography waveform feature
    • flecainide-treated mice exhibit a specific electrophysiologic signature as compare to wild-type mice   (MGI Ref ID J:185269)
    • abnormal QRS complex
      • fragmented time-course with decreased S wave amplitude   (MGI Ref ID J:185269)
      • decreased QRS amplitude   (MGI Ref ID J:185269)
      • prolonged QRS complex duration   (MGI Ref ID J:185269)
    • decreased P wave amplitude
      • in the frontal plane   (MGI Ref ID J:185269)
    • prolonged PR interval   (MGI Ref ID J:185269)
    • prolonged QT interval
      • larger QT and QTc   (MGI Ref ID J:185269)
    • prolonged RR interval   (MGI Ref ID J:185269)
  • abnormal heart morphology
    • great vessel and cardiac malformation in 1 of 18 mice that died postnatally   (MGI Ref ID J:185269)
    • ventricular septal defect
      • 1 in 18 newborns exhibit an upper communication of the ventricles, indication a septation defect of the ventricles   (MGI Ref ID J:185269)
  • decreased heart rate   (MGI Ref ID J:185269)
  • retroesophageal right subclavian artery
    • aberrant right subclavian artery arising from the distal part of the aortic arch   (MGI Ref ID J:185269)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Neurobiology Research
Down syndrome

Pde6b+ related

Sensorineural Research
Retinal Degeneration
      wild-type

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Ts(1716)65Dn
Allele Name trisomy, Chr 16 translocation to Chr 17, Davisson 65
Allele Type Radiation induced
Common Name(s) T(16C3-4;17A2)65Dn; Ts16; Ts65Dn;
Strain of OriginDBA/2J
Gene Symbol and Name Ts(1716)65Dn, trisomy, Chr 16 translocation to Chr 17, Davisson 65
Chromosome 16
Gene Common Name(s) Ts65Dn; trisomy 16;
Molecular Note About 15% of the distal end of chromosome 16 is fused to less than 10% of the centromeric end of chromosome 17 to form a small translocation chromosome. The translocation breaks mouse Chr 16 just proximal to the amyloid precursor protein ( App ) gene and contains the HSA21-homologous genes from App to the telomere. The translocation chromosome also contains the centromere and a small portion (~5%) of Chr 17. Northern and Western blotting and enzyme activity assays demonstrate that genes on the translocation product are expressed at elevated levels in segmentally trisomic animals. [MGI Ref ID J:30229] [MGI Ref ID J:71031]
 
Allele Symbol Pde6b+
Allele Name wild type
Allele Type Not Applicable
Mutation Made By Frank Kooy,   University of Antwerp
Gene Symbol and Name Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
Chromosome 5
Gene Common Name(s) CSNB3; CSNBAD2; PDEB; Pdeb; RP40; nmf137; phosphodiesterase, cGMP, rod receptor, beta polypeptide; r; rd; rd-1; rd1; rd10; retinal degeneration; retinal degeneration 1; retinal degeneration 10;

Genotyping

Genotyping Information

Genotyping Protocols

Ts1716, Melt Curve Analysis
Trisomy QPCR, QPCR
Ts(1716), Separated PCR
Ts1716, High Resolution Melting


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Ahmed MM; Sturgeon X; Ellison M; Davisson MT; Gardiner KJ. 2012. Loss of Correlations among Proteins in Brains of the Ts65Dn Mouse Model of Down Syndrome. J Proteome Res 11(2):1251-63. [PubMed: 22214338]  [MGI Ref ID J:180732]

Costa AC; Stasko MR; Schmidt C; Davisson MT. 2010. Behavioral validation of the Ts65Dn mouse model for Down syndrome of a genetic background free of the retinal degeneration mutation Pde6b(rd1). Behav Brain Res 206(1):52-62. [PubMed: 19720087]  [MGI Ref ID J:153579]

Reinholdt LG; Ding Y; Gilbert GT; Czechanski A; Solzak JP; Roper RJ; Johnson MT; Donahue LR; Lutz C; Davisson MT. 2011. Molecular characterization of the translocation breakpoints in the Down syndrome mouse model Ts65Dn. Mamm Genome 22(11-12):685-91. [PubMed: 21953412]  [MGI Ref ID J:178871]

Additional References

Belichenko NP; Belichenko PV; Kleschevnikov AM; Salehi A; Reeves RH; Mobley WC. 2009. The 'Down syndrome critical region' is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome. J Neurosci 29(18):5938-48. [PubMed: 19420260]  [MGI Ref ID J:148478]

Richtsmeier JT; Baxter LL; Reeves RH. 2000. Parallels of craniofacial maldevelopment in Down syndrome and Ts65Dn mice. Dev Dyn 217(2):137-45. [PubMed: 10706138]  [MGI Ref ID J:60229]

Pde6b+ related

Dobkin C; Rabe A; Dumas R; El Idrissi A; Haubenstock H; Brown WT. 2000. Fmr1 knockout mouse has a distinctive strain-specific learning impairment. Neuroscience 100(2):423-9. [PubMed: 11008180]  [MGI Ref ID J:119166]

Ivanco TL; Greenough WT. 2002. Altered mossy fiber distributions in adult Fmr1 (FVB) knockout mice. Hippocampus 12(1):47-54. [PubMed: 11918288]  [MGI Ref ID J:113177]

Sakamoto K; McCluskey M; Wensel TG; Naggert JK; Nishina PM. 2009. New mouse models for recessive retinitis pigmentosa caused by mutations in the Pde6a gene. Hum Mol Genet 18(1):178-92. [PubMed: 18849587]  [MGI Ref ID J:142108]

Zhao MG; Toyoda H; Ko SW; Ding HK; Wu LJ; Zhuo M. 2005. Deficits in trace fear memory and long-term potentiation in a mouse model for fragile X syndrome. J Neurosci 25(32):7385-92. [PubMed: 16093389]  [MGI Ref ID J:100197]

Ts(1716)65Dn related

Adorno M; Sikandar S; Mitra SS; Kuo A; Nicolis Di Robilant B; Haro-Acosta V; Ouadah Y; Quarta M; Rodriguez J; Qian D; Reddy VM; Cheshier S; Garner CC; Clarke MF. 2013. Usp16 contributes to somatic stem-cell defects in Down's syndrome. Nature 501(7467):380-4. [PubMed: 24025767]  [MGI Ref ID J:206099]

Akeson EC; Lambert JP; Narayanswami S; Gardiner K; Bechtel LJ; Davisson MT. 2001. Ts65Dn -- localization of the translocation breakpoint and trisomic gene content in a mouse model for Down syndrome. Cytogenet Cell Genet 93(3-4):270-6. [PubMed: 11528125]  [MGI Ref ID J:71031]

Altafaj X; Martin ED; Ortiz-Abalia J; Valderrama A; Lao-Peregrin C; Dierssen M; Fillat C. 2013. Normalization of Dyrk1A expression by AAV2/1-shDyrk1A attenuates hippocampal-dependent defects in the Ts65Dn mouse model of Down syndrome. Neurobiol Dis 52:117-27. [PubMed: 23220201]  [MGI Ref ID J:197665]

Arriagada C; Bustamante M; Atwater I; Rojas E; Caviedes R; Caviedes P. 2010. Apoptosis is directly related to intracellular amyloid accumulation in a cell line derived from the cerebral cortex of a trisomy 16 mouse, an animal model of Down syndrome. Neurosci Lett 470(1):81-5. [PubMed: 20043975]  [MGI Ref ID J:156873]

Aso S; Miyabara S; Sugihara H; Winking H. 2001. Comparative study of mouse trisomy 16 and bis-diamine treated fetuses: Discrimination of possible contribution of neural crest cells to malformations Cong Anom 41:169-176.  [MGI Ref ID J:104833]

Ayberk Kurt M; Ilker Kafa M; Dierssen M; Ceri Davies D. 2004. Deficits of neuronal density in CA1 and synaptic density in the dentate gyrus, CA3 and CA1, in a mouse model of Down syndrome. Brain Res 1022(1-2):101-9. [PubMed: 15353219]  [MGI Ref ID J:92543]

Baek KH; Zaslavsky A; Lynch RC; Britt C; Okada Y; Siarey RJ; Lensch MW; Park IH; Yoon SS; Minami T; Korenberg JR; Folkman J; Daley GQ; Aird WC; Galdzicki Z; Ryeom S. 2009. Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1. Nature 459(7250):1126-30. [PubMed: 19458618]  [MGI Ref ID J:150286]

Bambrick LL; Yarowsky PJ; Krueger BK. 2003. Altered astrocyte calcium homeostasis and proliferation in theTs65Dn mouse, a model of Down syndrome. J Neurosci Res 73(1):89-94. [PubMed: 12815712]  [MGI Ref ID J:173986]

Baxter LL; Moran TH; Richtsmeier JT; Troncoso J; Reeves RH. 2000. Discovery and genetic localization of Down syndrome cerebellar phenotypes using the Ts65Dn mouse. Hum Mol Genet 9(2):195-202. [PubMed: 10607830]  [MGI Ref ID J:59886]

Bearer EL; Zhang X; Jacobs RE. 2007. Live imaging of neuronal connections by magnetic resonance: Robust transport in the hippocampal-septal memory circuit in a mouse model of Down syndrome. Neuroimage 37(1):230-42. [PubMed: 17566763]  [MGI Ref ID J:173981]

Begenisic T; Spolidoro M; Braschi C; Baroncelli L; Milanese M; Pietra G; Fabbri ME; Bonanno G; Cioni G; Maffei L; Sale A. 2011. Environmental enrichment decreases GABAergic inhibition and improves cognitive abilities, synaptic plasticity, and visual functions in a mouse model of Down syndrome. Front Cell Neurosci 5:29. [PubMed: 22207837]  [MGI Ref ID J:190265]

Belichenko PV; Kleschevnikov AM; Masliah E; Wu C; Takimoto-Kimura R; Salehi A; Mobley WC. 2009. Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of Down syndrome. J Comp Neurol 512(4):453-66. [PubMed: 19034952]  [MGI Ref ID J:173987]

Belichenko PV; Kleschevnikov AM; Salehi A; Epstein CJ; Mobley WC. 2007. Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships. J Comp Neurol 504(4):329-45. [PubMed: 17663443]  [MGI Ref ID J:132525]

Belichenko PV; Masliah E; Kleschevnikov AM; Villar AJ; Epstein CJ; Salehi A; Mobley WC. 2004. Synaptic structural abnormalities in the Ts65Dn mouse model of Down Syndrome. J Comp Neurol 480(3):281-98. [PubMed: 15515178]  [MGI Ref ID J:94569]

Berg BM; Croom J; Fernandez JM; Spears JW; Eisen EJ; Taylor IL; Daniel LR; Coles BA; Boeheim F; Mannon PJ. 2000. Peptide YY administration decreases brain aluminum in the Ts65Dn Down syndrome mouse model Growth Dev Aging 64(1-2):3-19. [PubMed: 10969882]  [MGI Ref ID J:63856]

Best TK; Cho-Clark M; Siarey RJ; Galdzicki Z. 2008. Speeding of miniature excitatory post-synaptic currents in Ts65Dn cultured hippocampal neurons. Neurosci Lett 438(3):356-61. [PubMed: 18490108]  [MGI Ref ID J:173980]

Best TK; Cramer NP; Chakrabarti L; Haydar TF; Galdzicki Z. 2012. Dysfunctional hippocampal inhibition in the Ts65Dn mouse model of Down syndrome. Exp Neurol 233(2):749-57. [PubMed: 22178330]  [MGI Ref ID J:182047]

Best TK; Siarey RJ; Galdzicki Z. 2007. Ts65Dn, a mouse model of Down syndrome, exhibits increased GABAB-induced potassium current. J Neurophysiol 97(1):892-900. [PubMed: 17093127]  [MGI Ref ID J:135917]

Bhutta MF; Cheeseman MT; Herault Y; Yu YE; Brown SD. 2013. Surveying the Down syndrome mouse model resource identifies critical regions responsible for chronic otitis media. Mamm Genome :. [PubMed: 24068166]  [MGI Ref ID J:201811]

Bianchi P; Bettini S; Guidi S; Ciani E; Trazzi S; Stagni F; Ragazzi E; Franceschini V; Bartesaghi R. 2014. Age-related impairment of olfactory bulb neurogenesis in the Ts65Dn mouse model of Down syndrome. Exp Neurol 251:1-11. [PubMed: 24192151]  [MGI Ref ID J:206601]

Bianchi P; Ciani E; Contestabile A; Guidi S; Bartesaghi R. 2010. Lithium restores neurogenesis in the subventricular zone of the Ts65Dn mouse, a model for Down syndrome. Brain Pathol 20(1):106-18. [PubMed: 19298631]  [MGI Ref ID J:173984]

Bimonte-Nelson HA; Hunter CL; Nelson ME; Granholm AC. 2003. Frontal cortex BDNF levels correlate with working memory in an animal model of Down syndrome. Behav Brain Res 139(1-2):47-57. [PubMed: 12642175]  [MGI Ref ID J:95711]

Blank M; Fuerst PG; Stevens B; Nouri N; Kirkby L; Warrier D; Barres BA; Feller MB; Huberman AD; Burgess RW; Garner CC. 2011. The Down Syndrome Critical Region Regulates Retinogeniculate Refinement. J Neurosci 31(15):5764-5776. [PubMed: 21490218]  [MGI Ref ID J:170968]

Blazek JD; Billingsley CN; Newbauer A; Roper RJ. 2010. Embryonic and not maternal trisomy causes developmental attenuation in the Ts65Dn mouse model for Down syndrome. Dev Dyn 239(6):1645-53. [PubMed: 20503361]  [MGI Ref ID J:160592]

Blazek JD; Gaddy A; Meyer R; Roper RJ; Li J. 2011. Disruption of bone development and homeostasis by trisomy in Ts65Dn Down syndrome mice. Bone 48(2):275-80. [PubMed: 20870049]  [MGI Ref ID J:170199]

Casas C; Martinez S; Pritchard MA; Fuentes JJ; Nadal M; Guimera J; Arbones M; Florez J; Soriano E; Estivill X; Alcantara S. 2001. Dscr1, a novel endogenous inhibitor of calcineurin signaling, is expressed in the primitive ventricle of the heart and during neurogenesis. Mech Dev 101(1-2):289-92. [PubMed: 11231093]  [MGI Ref ID J:68156]

Cataldo AM; Petanceska S; Peterhoff CM; Terio NB; Epstein CJ; Villar A; Carlson EJ; Staufenbiel M; Nixon RA. 2003. App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome. J Neurosci 23(17):6788-92. [PubMed: 12890772]  [MGI Ref ID J:84685]

Cefalu JA; Croom WJ Jr; Eisen EJ; Jones EE; Daniel LR; Taylor IL. 1998. Jejunal function and plasma amino acid concentrations in the segmental trisomic Ts65Dn mouse. Growth Dev Aging 62(1-2):47-59. [PubMed: 9666356]  [MGI Ref ID J:48496]

Chakrabarti L; Best TK; Cramer NP; Carney RS; Isaac JT; Galdzicki Z; Haydar TF. 2010. Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome. Nat Neurosci 13(8):927-34. [PubMed: 20639873]  [MGI Ref ID J:163767]

Chakrabarti L; Galdzicki Z; Haydar TF. 2007. Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of Down syndrome. J Neurosci 27(43):11483-95. [PubMed: 17959791]  [MGI Ref ID J:127045]

Chang Q; Gold PE. 2008. Age-related changes in memory and in acetylcholine functions in the hippocampus in the Ts65Dn mouse, a model of Down syndrome. Neurobiol Learn Mem 89(2):167-77. [PubMed: 17644430]  [MGI Ref ID J:128851]

Chen Y; Dyakin VV; Branch CA; Ardekani B; Yang D; Guilfoyle DN; Peterson J; Peterhoff C; Ginsberg SD; Cataldo AM; Nixon RA. 2009. In vivo MRI identifies cholinergic circuitry deficits in a Down syndrome model. Neurobiol Aging 30(9):1453-65. [PubMed: 18180075]  [MGI Ref ID J:152960]

Choi JH; Berger JD; Mazzella MJ; Morales-Corraliza J; Cataldo AM; Nixon RA; Ginsberg SD; Levy E; Mathews PM. 2009. Age-dependent dysregulation of brain amyloid precursor protein in the Ts65Dn Down syndrome mouse model. J Neurochem 110(6):1818-27. [PubMed: 19619138]  [MGI Ref ID J:152489]

Chrast R; Scott HS; Papasavvas MP; Rossier C; Antonarakis ES; Barras C; Davisson MT; Schmidt C; Estivill X; Dierssen M; Pritchard M; Antonarakis SE. 2000. The mouse brain transcriptome by SAGE: differences in gene expression between P30 brains of the partial trisomy 16 mouse model of down syndrome (Ts65Dn) and normals Genome Res 10(12):2006-21. [PubMed: 11116095]  [MGI Ref ID J:66235]

Colas D; Valletta JS; Takimoto-Kimura R; Nishino S; Fujiki N; Mobley WC; Mignot E. 2008. Sleep and EEG features in genetic models of Down syndrome. Neurobiol Dis 30(1):1-7. [PubMed: 18282758]  [MGI Ref ID J:136520]

Contestabile A; Fila T; Bartesaghi R; Ciani E. 2009. Cell cycle elongation impairs proliferation of cerebellar granule cell precursors in the Ts65Dn mouse, an animal model for Down syndrome. Brain Pathol 19(2):224-37. [PubMed: 18482164]  [MGI Ref ID J:174271]

Contestabile A; Fila T; Bartesaghi R; Contestabile A; Ciani E. 2006. Choline acetyltransferase activity at different ages in brain of Ts65Dn mice, an animal model for Down's syndrome and related neurodegenerative diseases. J Neurochem 97(2):515-26. [PubMed: 16539660]  [MGI Ref ID J:109560]

Contestabile A; Fila T; Cappellini A; Bartesaghi R; Ciani E. 2009. Widespread impairment of cell proliferation in the neonate Ts65Dn mouse, a model for Down syndrome. Cell Prolif 42(2):171-81. [PubMed: 19317805]  [MGI Ref ID J:173979]

Contestabile A; Fila T; Ceccarelli C; Bonasoni P; Bonapace L; Santini D; Bartesaghi R; Ciani E. 2007. Cell cycle alteration and decreased cell proliferation in the hippocampal dentate gyrus and in the neocortical germinal matrix of fetuses with Down syndrome and in Ts65Dn mice. Hippocampus 17(8):665-78. [PubMed: 17546680]  [MGI Ref ID J:173985]

Contestabile A; Greco B; Ghezzi D; Tucci V; Benfenati F; Gasparini L. 2013. Lithium rescues synaptic plasticity and memory in Down syndrome mice. J Clin Invest 123(1):348-61. [PubMed: 23202733]  [MGI Ref ID J:194179]

Cooper JD; Salehi A; Delcroix JD; Howe CL; Belichenko PV; Chua-Couzens J; Kilbridge JF; Carlson EJ; Epstein CJ; Mobley WC. 2001. Failed retrograde transport of NGF in a mouse model of Down's syndrome: reversal of cholinergic neurodegenerative phenotypes following NGF infusion. Proc Natl Acad Sci U S A 98(18):10439-44. [PubMed: 11504920]  [MGI Ref ID J:95716]

Costa AC; Grybko MJ. 2005. Deficits in hippocampal CA1 LTP induced by TBS but not HFS in the Ts65Dn mouse: a model of Down syndrome. Neurosci Lett 382(3):317-22. [PubMed: 15925111]  [MGI Ref ID J:99714]

Costa AC; Scott-McKean JJ; Stasko MR. 2008. Acute injections of the NMDA receptor antagonist memantine rescue performance deficits of the Ts65Dn mouse model of Down syndrome on a fear conditioning test. Neuropsychopharmacology 33(7):1624-32. [PubMed: 17700645]  [MGI Ref ID J:173990]

Costa AC; Walsh K; Davisson MT. 1999. Motor dysfunction in a mouse model for Down syndrome. Physiol Behav 68(1-2):211-20. [PubMed: 10627083]  [MGI Ref ID J:95719]

Coussons-Read ME; Crnic LS. 1996. Behavioral assessment of the Ts65Dn mouse, a model for Down syndrome: altered behavior in the elevated plus maze and open field. Behav Genet 26(1):7-13. [PubMed: 8852727]  [MGI Ref ID J:173989]

Davisson M; Akeson E; Schmidt C; Harris B; Farley J; Handel MA. 2007. Impact of trisomy on fertility and meiosis in male mice. Hum Reprod 22(2):468-76. [PubMed: 17050550]  [MGI Ref ID J:117029]

Davisson MT. 2005. Mouse models of Down syndrome Drug Discov Today 2(2):103-109.  [MGI Ref ID J:173982]

Davisson MT; Costa ACS. 1999. Mouse models of Down Syndrome Adv Neurochem 9:297-327.  [MGI Ref ID J:174349]

Davisson MT; Schmidt C; Reeves RH; Irving NG; Akeson EC; Harris BS; Bronson RT. 1993. Segmental trisomy as a mouse model for Down syndrome. Prog Clin Biol Res 384:117-33. [PubMed: 8115398]  [MGI Ref ID J:30229]

Demas GE; Nelson RJ; Krueger BK; Yarowsky PJ. 1998. Impaired spatial working and reference memory in segmental trisomy (Ts65Dn) mice. Behav Brain Res 90(2):199-201. [PubMed: 9521551]  [MGI Ref ID J:95722]

Demas GE; Nelson RJ; Krueger BK; Yarowsky PJ. 1996. Spatial memory deficits in segmental trisomic Ts65Dn mice. Behav Brain Res 82(1):85-92. [PubMed: 9021073]  [MGI Ref ID J:173988]

Di Filippo M; Tozzi A; Ghiglieri V; Picconi B; Costa C; Cipriani S; Tantucci M; Belcastro V; Calabresi P. 2010. Impaired plasticity at specific subset of striatal synapses in the Ts65Dn mouse model of Down syndrome. Biol Psychiatry 67(7):666-71. [PubMed: 19818432]  [MGI Ref ID J:173983]

Dierssen M; Benavides-Piccione R; Martinez-Cue C; Estivill X; Florez J; Elston GN; DeFelipe J. 2003. Alterations of neocortical pyramidal cell phenotype in the Ts65Dn mouse model of Down syndrome: effects of environmental enrichment. Cereb Cortex 13(7):758-64. [PubMed: 12816891]  [MGI Ref ID J:102148]

Dierssen M; Vallina IF; Baamonde C; Garcia-Calatayud S; Lumbreras MA; Florez J. 1997. Alterations of central noradrenergic transmission in Ts65Dn mouse, a model for Down syndrome. Brain Res 749(2):238-44. [PubMed: 9138724]  [MGI Ref ID J:39408]

Dowdy-Sanders NC; Wenger GR. 2006. Working memory in the Ts65Dn mouse, a model for Down syndrome. Behav Brain Res 168(2):349-52. [PubMed: 16386318]  [MGI Ref ID J:174273]

Driscoll LL; Carroll JC; Moon J; Crnic LS; Levitsky DA; Strupp BJ. 2004. Impaired sustained attention and error-induced stereotypy in the aged Ts65Dn mouse: a mouse model of Down syndrome and Alzheimer's disease. Behav Neurosci 118(6):1196-205. [PubMed: 15598129]  [MGI Ref ID J:174344]

Duchon A; Raveau M; Chevalier C; Nalesso V; Sharp AJ; Herault Y. 2011. Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling down syndrome. Mamm Genome 22(11-12):674-84. [PubMed: 21953411]  [MGI Ref ID J:178872]

Escorihuela RM; Fernandez-Teruel A; Vallina IF; Baamonde C; Lumbreras MA; Dierssen M; Tobena A; Florez J. 1995. A behavioral assessment of Ts65Dn mice: a putative Down syndrome model. Neurosci Lett 199(2):143-6. [PubMed: 8584244]  [MGI Ref ID J:174275]

Escorihuela RM; Vallina IF; Martinez-Cue C; Baamonde C; Dierssen M; Tobena A; Florez J; Fernandez-Teruel A. 1998. Impaired short- and long-term memory in Ts65Dn mice, a model for Down syndrome. Neurosci Lett 247(2-3):171-4. [PubMed: 9655620]  [MGI Ref ID J:95721]

Faizi M; Bader PL; Tun C; Encarnacion A; Kleschevnikov A; Belichenko P; Saw N; Priestley M; Tsien RW; Mobley WC; Shamloo M. 2011. Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down Syndrome: Activation of beta(1)-adrenergic receptor by xamoterol as a potential cognitive enhancer. Neurobiol Dis 43(2):397-413. [PubMed: 21527343]  [MGI Ref ID J:173180]

Fernandez F; Garner CC. 2008. Episodic-like memory in Ts65Dn, a mouse model of Down syndrome. Behav Brain Res 188(1):233-7. [PubMed: 17950473]  [MGI Ref ID J:130535]

Fernandez F; Trinidad JC; Blank M; Feng DD; Burlingame AL; Garner CC. 2009. Normal protein composition of synapses in Ts65Dn mice: a mouse model of Down syndrome. J Neurochem 110(1):157-69. [PubMed: 19453946]  [MGI Ref ID J:150749]

Fowler TW; McKelvey KD; Akel NS; Vander Schilden J; Bacon AW; Bracey JW; Sowder T; Skinner RA; Swain FL; Hogue WR; Leblanc DB; Gaddy D; Wenger GR; Suva LJ. 2012. Low bone turnover and low BMD in Down syndrome: effect of intermittent PTH treatment. PLoS One 7(8):e42967. [PubMed: 22916188]  [MGI Ref ID J:190052]

Fuchs C; Ciani E; Guidi S; Trazzi S; Bartesaghi R. 2012. Early-occurring proliferation defects in peripheral tissues of the Ts65Dn mouse model of Down syndrome are associated with patched1 over expression. Lab Invest 92(11):1648-60. [PubMed: 22890555]  [MGI Ref ID J:189812]

Galdzicki Z; Siarey R; Pearce R; Stoll J; Rapoport SI. 2001. On the cause of mental retardation in Down syndrome: extrapolation from full and segmental trisomy 16 mouse models. Brain Res Brain Res Rev 35(2):115-45. [PubMed: 11336779]  [MGI Ref ID J:69888]

Galdzicki Z; Siarey RJ. 2003. Understanding mental retardation in Down's syndrome using trisomy 16 mouse models. Genes Brain Behav 2(3):167-78. [PubMed: 12931790]  [MGI Ref ID J:104907]

Gotti S; Chiavegatto S; Sica M; Viglietti-Panzica C; Nelson RJ; Panzica G. 2004. Alteration of NO-producing system in the basal forebrain and hypothalamus of Ts65Dn mice: an immunohistochemical and histochemical study of a murine model for Down syndrome. Neurobiol Dis 16(3):563-71. [PubMed: 15262268]  [MGI Ref ID J:91857]

Granholm AC; Ford KA; Hyde LA; Bimonte HA; Hunter CL; Nelson M; Albeck D; Sanders LA; Mufson EJ; Crnic LS. 2002. Estrogen restores cognition and cholinergic phenotype in an animal model of Down syndrome. Physiol Behav 77(2-3):371-85. [PubMed: 12419414]  [MGI Ref ID J:95714]

Granholm AC; Sanders LA; Crnic LS. 2000. Loss of cholinergic phenotype in basal forebrain coincides with cognitive decline in a mouse model of Down's syndrome. Exp Neurol 161(2):647-63. [PubMed: 10686084]  [MGI Ref ID J:60959]

Guedj F; Pereira PL; Najas S; Barallobre MJ; Chabert C; Souchet B; Sebrie C; Verney C; Herault Y; Arbones M; Delabar JM. 2012. DYRK1A: A master regulatory protein controlling brain growth. Neurobiol Dis 46(1):190-203. [PubMed: 22293606]  [MGI Ref ID J:182294]

Gutierrez-Castellanos N; Winkelman BH; Tolosa-Rodriguez L; Devenney B; Reeves RH; De Zeeuw CI. 2013. Size does not always matter: Ts65Dn Down syndrome mice show cerebellum-dependent motor learning deficits that cannot be rescued by postnatal SAG treatment. J Neurosci 33(39):15408-13. [PubMed: 24068809]  [MGI Ref ID J:202685]

Hampton TG; Stasko MR; Kale A; Amende I; Costa AC. 2004. Gait dynamics in trisomic mice: quantitative neurological traits of Down syndrome. Physiol Behav 82(2-3):381-9. [PubMed: 15276802]  [MGI Ref ID J:95704]

Han F; Yu H; Zhang J; Tian C; Schmidt C; Nava C; Davisson MT; Zheng QY. 2009. Otitis media in a mouse model for Down syndrome. Int J Exp Pathol 90(5):480-8. [PubMed: 19765102]  [MGI Ref ID J:154717]

Hanson JE; Blank M; Valenzuela RA; Garner CC; Madison DV. 2007. The functional nature of synaptic circuitry is altered in area CA3 of the hippocampus in a mouse model of Down's syndrome. J Physiol 579(Pt 1):53-67. [PubMed: 17158177]  [MGI Ref ID J:140845]

Harashima C; Jacobowitz DM; Stoffel M; Chakrabarti L; Haydar TF; Siarey RJ; Galdzicki Z. 2006. Elevated expression of the G-protein-activated inwardly rectifying potassium channel 2 (GIRK2) in cerebellar unipolar brush cells of a Down syndrome mouse model. Cell Mol Neurobiol 26(4-6):719-34. [PubMed: 16783527]  [MGI Ref ID J:174334]

Harashima C; Jacobowitz DM; Witta J; Borke RC; Best TK; Siarey RJ; Galdzicki Z. 2006. Abnormal expression of the G-protein-activated inwardly rectifying potassium channel 2 (GIRK2) in hippocampus, frontal cortex, and substantia nigra of Ts65Dn mouse: a model of Down syndrome. J Comp Neurol 494(5):815-33. [PubMed: 16374808]  [MGI Ref ID J:174347]

Herrera F; Chen Q; Fischer WH; Maher P; Schubert DR. 2009. Synaptojanin-1 plays a key role in astrogliogenesis: possible relevance for Down's syndrome. Cell Death Differ 16(6):910-20. [PubMed: 19282871]  [MGI Ref ID J:164187]

Hijazi M; Fillat C; Medina JM; Velasco A. 2013. Overexpression of DYRK1A inhibits choline acetyltransferase induction by oleic acid in cellular models of Down syndrome. Exp Neurol 239:229-34. [PubMed: 23124096]  [MGI Ref ID J:196990]

Hill CA; Reeves RH; Richtsmeier JT. 2007. Effects of aneuploidy on skull growth in a mouse model of Down syndrome. J Anat 210(4):394-405. [PubMed: 17428201]  [MGI Ref ID J:129637]

Hill JM; Ades AM; McCune SK; Sahir N; Moody EM; Abebe DT; Crnic LS; Brenneman DE. 2003. Vasoactive intestinal peptide in the brain of a mouse model for Down syndrome. Exp Neurol 183(1):56-65. [PubMed: 12957488]  [MGI Ref ID J:85337]

Holtzman DM; Santucci D; Kilbridge J; Chua-Couzens J; Fontana DJ; Daniels SE; Johnson RM; Chen K; Sun Y; Carlson E; Alleva E; Epstein CJ; Mobley WC. 1996. Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome. Proc Natl Acad Sci U S A 93(23):13333-8. [PubMed: 8917591]  [MGI Ref ID J:36555]

Huang W; Galdzicki Z; van Gelderen P; Balbo A; Chikhale EG; Schapiro MB; Rapoport SI. 2000. Brain myo-inositol level is elevated in Ts65Dn mouse and reduced after lithium treatment. Neuroreport 11(3):445-8. [PubMed: 10718292]  [MGI Ref ID J:103600]

Hunter CL; Bimonte HA; Granholm AC. 2003. Behavioral comparison of 4 and 6 month-old Ts65Dn mice: age-related impairments in working and reference memory. Behav Brain Res 138(2):121-31. [PubMed: 12527443]  [MGI Ref ID J:95712]

Hunter CL; Bimonte-Nelson HA; Nelson M; Eckman CB; Granholm AC. 2004. Behavioral and neurobiological markers of Alzheimer's disease in Ts65Dn mice: effects of estrogen. Neurobiol Aging 25(7):873-84. [PubMed: 15212841]  [MGI Ref ID J:95707]

Hunter CL; Isacson O; Nelson M; Bimonte-Nelson H; Seo H; Lin L; Ford K; Kindy MS; Granholm AC. 2003. Regional alterations in amyloid precursor protein and nerve growth factor across age in a mouse model of Down's syndrome. Neurosci Res 45(4):437-45. [PubMed: 12657457]  [MGI Ref ID J:95710]

Hyde LA; Crnic LS. 2001. Age-related deficits in context discrimination learning in Ts65Dn mice that model Down syndrome and Alzheimer's disease. Behav Neurosci 115(6):1239-46. [PubMed: 11770055]  [MGI Ref ID J:174345]

Hyde LA; Crnic LS. 2002. Reactivity to object and spatial novelty is normal in older Ts65Dn mice that model Down syndrome and Alzheimer's disease. Brain Res 945(1):26-30. [PubMed: 12113948]  [MGI Ref ID J:78188]

Hyde LA; Frisone DF; Crnic LS. 2001. Ts65Dn mice, a model for Down syndrome, have deficits in context discrimination learning suggesting impaired hippocampal function. Behav Brain Res 118(1):53-60. [PubMed: 11163633]  [MGI Ref ID J:95717]

Incerti M; Horowitz K; Roberson R; Abebe D; Toso L; Caballero M; Spong CY. 2012. Prenatal treatment prevents learning deficit in Down syndrome model. PLoS One 7(11):e50724. [PubMed: 23209818]  [MGI Ref ID J:194780]

Insausti AM; Megias M; Crespo D; Cruz-Orive LM; Dierssen M; Vallina IF; Insausti R; Florez J. 1998. Hippocampal volume and neuronal number in Ts65Dn mice: a murine model of Down syndrome. Neurosci Lett 253(3):175-8. [PubMed: 9792239]  [MGI Ref ID J:95720]

Kahlem P; Sultan M; Herwig R; Steinfath M; Balzereit D; Eppens B; Saran NG; Pletcher MT; South ST; Stetten G; Lehrach H; Reeves RH; Yaspo ML. 2004. Transcript level alterations reflect gene dosage effects across multiple tissues in a mouse model of down syndrome. Genome Res 14(7):1258-67. [PubMed: 15231742]  [MGI Ref ID J:95706]

Kida E; Rabe A; Walus M; Albertini G; Golabek AA. 2013. Long-term running alleviates some behavioral and molecular abnormalities in Down syndrome mouse model Ts65Dn. Exp Neurol 240:178-89. [PubMed: 23201095]  [MGI Ref ID J:196979]

Kirsammer G; Jilani S; Liu H; Davis E; Gurbuxani S; Le Beau MM; Crispino JD. 2008. Highly penetrant myeloproliferative disease in the Ts65Dn mouse model of Down syndrome. Blood 111(2):767-75. [PubMed: 17901249]  [MGI Ref ID J:130041]

Klein SL; Kriegsfeld LJ; Hairston JE; Rau V; Nelson RJ; Yarowsky PJ. 1996. Characterization of sensorimotor performance, reproductive and aggressive behaviors in segmental trisomic 16 (Ts65Dn) mice. Physiol Behav 60(4):1159-64. [PubMed: 8884947]  [MGI Ref ID J:174274]

Kleschevnikov AM; Belichenko PV; Gall J; George L; Nosheny R; Maloney MT; Salehi A; Mobley WC. 2012. Increased efficiency of the GABAA and GABAB receptor-mediated neurotransmission in the Ts65Dn mouse model of Down syndrome. Neurobiol Dis 45(2):683-91. [PubMed: 22062771]  [MGI Ref ID J:182052]

Kleschevnikov AM; Belichenko PV; Villar AJ; Epstein CJ; Malenka RC; Mobley WC. 2004. Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome. J Neurosci 24(37):8153-60. [PubMed: 15371516]  [MGI Ref ID J:95702]

Kurt MA; Davies DC; Kidd M; Dierssen M; Florez J. 2000. Synaptic deficit in the temporal cortex of partial trisomy 16 (Ts65Dn) mice. Brain Res 858(1):191-7. [PubMed: 10700614]  [MGI Ref ID J:95718]

Laguna A; Barallobre MJ; Marchena MA; Mateus C; Ramirez E; Martinez-Cue C; Delabar JM; Castelo-Branco M; de la Villa P; Arbones ML. 2013. Triplication of DYRK1A causes retinal structural and functional alterations in Down syndrome. Hum Mol Genet 22(14):2775-84. [PubMed: 23512985]  [MGI Ref ID J:198546]

Levine S; Saltzman A; Levy E; Ginsberg SD. 2009. Systemic pathology in aged mouse models of Down's syndrome and Alzheimer's disease. Exp Mol Pathol 86(1):18-22. [PubMed: 19041304]  [MGI Ref ID J:174270]

Liu DP; Schmidt C; Billings T; Davisson MT. 2003. Quantitative PCR genotyping assay for the Ts65Dn mouse model of Down syndrome. Biotechniques 35(6):1170-4, 1176, 1178 passim. [PubMed: 14682051]  [MGI Ref ID J:112549]

Llorens-Martin MV; Rueda N; Tejeda GS; Florez J; Trejo JL; Martinez-Cue C. 2010. Effects of voluntary physical exercise on adult hippocampal neurogenesis and behavior of Ts65Dn mice, a model of Down syndrome. Neuroscience 171(4):1228-40. [PubMed: 20875841]  [MGI Ref ID J:170195]

Lockrow J; Prakasam A; Huang P; Bimonte-Nelson H; Sambamurti K; Granholm AC. 2009. Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse model. Exp Neurol 216(2):278-89. [PubMed: 19135442]  [MGI Ref ID J:147308]

Lomoio S; Scherini E; Necchi D. 2009. Beta-amyloid overload does not directly correlate with SAPK/JNK activation and tau protein phosphorylation in the cerebellar cortex of Ts65Dn mice. Brain Res 1297:198-206. [PubMed: 19703431]  [MGI Ref ID J:157413]

Lorandeau CG; Hakkinen LA; Moore CS. 2011. Cardiovascular development and survival during gestation in the Ts65Dn mouse model for down syndrome. Anat Rec (Hoboken) 294(1):93-101. [PubMed: 21157920]  [MGI Ref ID J:173508]

Lorenzi HA; Reeves RH. 2006. Hippocampal hypocellularity in the Ts65Dn mouse originates early in development. Brain Res 1104(1):153-9. [PubMed: 16828061]  [MGI Ref ID J:111633]

Lorenzo LP; Shatynski KE; Clark S; Yarowsky PJ; Williams MS. 2013. Defective thymic progenitor development and mature T-cell responses in a mouse model for Down syndrome. Immunology 139(4):447-58. [PubMed: 23432468]  [MGI Ref ID J:202187]

Lyle R; Gehrig C; Neergaard-Henrichsen C; Deutsch S; Antonarakis SE. 2004. Gene expression from the aneuploid chromosome in a trisomy mouse model of down syndrome. Genome Res 14(7):1268-74. [PubMed: 15231743]  [MGI Ref ID J:95705]

Martinez-Cue C; Baamonde C; Lumbreras M; Paz J; Davisson MT; Schmidt C; Dierssen M; Florez J. 2002. Differential effects of environmental enrichment on behavior and learning of male and female Ts65Dn mice, a model for Down syndrome. Behav Brain Res 134(1-2):185-200. [PubMed: 12191805]  [MGI Ref ID J:95715]

Martinez-Cue C; Baamonde C; Lumbreras MA; Vallina IF; Dierssen M; Florez J. 1999. A murine model for Down syndrome shows reduced responsiveness to pain. Neuroreport 10(5):1119-22. [PubMed: 10321494]  [MGI Ref ID J:174342]

Martinez-Cue C; Rueda N; Garcia E; Davisson MT; Schmidt C; Florez J. 2005. Behavioral, cognitive and biochemical responses to different environmental conditions in male Ts65Dn mice, a model of Down syndrome. Behav Brain Res 163(2):174-85. [PubMed: 15941601]  [MGI Ref ID J:100647]

Martinez-Cue C; Rueda N; Garcia E; Florez J. 2006. Anxiety and panic responses to a predator in male and female Ts65Dn mice, a model for Down syndrome. Genes Brain Behav 5(5):413-22. [PubMed: 16879635]  [MGI Ref ID J:123653]

Megias M; Verduga R; Dierssen M; Florez J; Insausti R; Crespo D. 1997. Cholinergic, serotonergic and catecholaminergic neurons are not affected in Ts65Dn mice. Neuroreport 8(16):3475-8. [PubMed: 9427310]  [MGI Ref ID J:103727]

Mitra A; Blank M; Madison DV. 2012. Developmentally altered inhibition in Ts65Dn, a mouse model of Down syndrome. Brain Res 1440:1-8. [PubMed: 22284618]  [MGI Ref ID J:181873]

Moore CS. 2006. Postnatal lethality and cardiac anomalies in the Ts65Dn Down syndrome mouse model. Mamm Genome 17(10):1005-12. [PubMed: 17019652]  [MGI Ref ID J:115042]

Moore CS; Hawkins C; Franca A; Lawler A; Devenney B; Das I; Reeves RH. 2010. Increased male reproductive success in Ts65Dn 'Down syndrome' mice. Mamm Genome 21(11-12):543-9. [PubMed: 21110029]  [MGI Ref ID J:166752]

Moran TH; Capone GT; Knipp S; Davisson MT; Reeves RH; Gearhart JD. 2002. The effects of piracetam on cognitive performance in a mouse model of Down's syndrome. Physiol Behav 77(2-3):403-9. [PubMed: 12419416]  [MGI Ref ID J:95713]

Necchi D; Lomoio S; Scherini E. 2008. Axonal abnormalities in cerebellar Purkinje cells of the Ts65Dn mouse. Brain Res 1238:181-8. [PubMed: 18755166]  [MGI Ref ID J:147643]

Necchi D; Lomoio S; Scherini E. 2011. Dysfunction of the ubiquitin-proteasome system in the cerebellum of aging Ts65Dn mice. Exp Neurol 232(2):114-8. [PubMed: 21867700]  [MGI Ref ID J:178390]

Netzer WJ; Powell C; Nong Y; Blundell J; Wong L; Duff K; Flajolet M; Greengard P. 2010. Lowering beta-amyloid levels rescues learning and memory in a Down syndrome mouse model. PLoS One 5(6):e10943. [PubMed: 20532168]  [MGI Ref ID J:161812]

Ng AP; Hyland CD; Metcalf D; Carmichael CL; Loughran SJ; Di Rago L; Kile BT; Alexander WS. 2010. Trisomy of Erg is required for myeloproliferation in a mouse model of Down syndrome. Blood 115(19):3966-9. [PubMed: 20007548]  [MGI Ref ID J:160280]

Noll C; Planque C; Ripoll C; Guedj F; Diez A; Ducros V; Belin N; Duchon A; Paul JL; Badel A; de Freminville B; Grattau Y; Blehaut H; Herault Y; Janel N; Delabar JM. 2009. DYRK1A, a novel determinant of the methionine-homocysteine cycle in different mouse models overexpressing this Down-syndrome-associated kinase. PLoS One 4(10):e7540. [PubMed: 19844572]  [MGI Ref ID J:154042]

O'Leary DA; Pritchard MA; Xu D; Kola I; Hertzog PJ; Ristevski S. 2004. Tissue-specific overexpression of the HSA21 gene GABPalpha: implications for DS. Biochim Biophys Acta 1739(1):81-7. [PubMed: 15607120]  [MGI Ref ID J:95701]

Olson LE; Richtsmeier JT; Leszl J; Reeves RH. 2004. A chromosome 21 critical region does not cause specific down syndrome phenotypes. Science 306(5696):687-90. [PubMed: 15499018]  [MGI Ref ID J:93223]

Olson LE; Roper RJ; Baxter LL; Carlson EJ; Epstein CJ; Reeves RH. 2004. Down syndrome mouse models Ts65Dn, Ts1Cje, and Ms1Cje/Ts65Dn exhibit variable severity of cerebellar phenotypes. Dev Dyn 230(3):581-9. [PubMed: 15188443]  [MGI Ref ID J:91221]

Olson LE; Roper RJ; Sengstaken CL; Peterson EA; Aquino V; Galdzicki Z; Siarey R; Pletnikov M; Moran TH; Reeves RH. 2007. Trisomy for the Down syndrome 'critical region' is necessary but not sufficient for brain phenotypes of trisomic mice. Hum Mol Genet 16(7):774-82. [PubMed: 17339268]  [MGI Ref ID J:121764]

Palminiello S; Kida E; Kaur K; Walus M; Wisniewski KE; Wierzba-Bobrowicz T; Rabe A; Albertini G; Golabek AA. 2008. Increased levels of carbonic anhydrase II in the developing Down syndrome brain. Brain Res 1190:193-205. [PubMed: 18083150]  [MGI Ref ID J:130837]

Paz-Miguel JE; Flores R; Sanchez-Velasco P; Ocejo-Vinyals G; Escribano de Diego J; Lopez de Rego J; Leyva-Cobian F. 1999. Reactive oxygen intermediates during programmed cell death induced in the thymus of the Ts(1716)65Dn mouse, a murine model for human Down's syndrome. J Immunol 163(10):5399-410. [PubMed: 10553065]  [MGI Ref ID J:58452]

Paz-Miguel JE; Pardo-Manuel de Villena F; Sanchez-Velasco P; Leyva-Cobian F. 2001. H2-haplotype-dependent unequal transmission of the 17(16) translocation chromosome from Ts65Dn females. Mamm Genome 12(1):83-5. [PubMed: 11178750]  [MGI Ref ID J:68688]

Peng S; Garzon DJ; Marchese M; Klein W; Ginsberg SD; Francis BM; Mount HT; Mufson EJ; Salehi A; Fahnestock M. 2009. Decreased brain-derived neurotrophic factor depends on amyloid aggregation state in transgenic mouse models of Alzheimer's disease. J Neurosci 29(29):9321-9. [PubMed: 19625522]  [MGI Ref ID J:151795]

Pollonini G; Gao V; Rabe A; Palminiello S; Albertini G; Alberini CM. 2008. Abnormal expression of synaptic proteins and neurotrophin-3 in the Down syndrome mouse model Ts65Dn. Neuroscience 156(1):99-106. [PubMed: 18703118]  [MGI Ref ID J:140854]

Rachidi M; Lopes C. 2007. Mental retardation in Down syndrome: from gene dosage imbalance to molecular and cellular mechanisms. Neurosci Res 59(4):349-69. [PubMed: 17897742]  [MGI Ref ID J:128743]

Rachubinski AL; Maclean KN; Evans JR; Bjugstad KB. 2012. Modulating cognitive deficits and tau accumulation in a mouse model of aging Down syndrome through neonatal implantation of neural progenitor cells. Exp Gerontol 47(9):723-33. [PubMed: 22776132]  [MGI Ref ID J:203590]

Ramakrishna N; Meeker HC; Li S; Brown WT; Rao R; El Idrissi A. 2009. Upregulation of beta-catenin expression in down syndrome model Ts65Dn mouse brain. Neuroscience 161(2):451-8. [PubMed: 19328224]  [MGI Ref ID J:152941]

Raveau M; Lignon JM; Nalesso V; Duchon A; Groner Y; Sharp AJ; Dembele D; Brault V; Herault Y. 2012. The app-runx1 region is critical for birth defects and electrocardiographic dysfunctions observed in a down syndrome mouse model. PLoS Genet 8(5):e1002724. [PubMed: 22693452]  [MGI Ref ID J:185269]

Reeves RH; Irving NG; Moran TH; Wohn A; Kitt C; Sisodia SS; Schmidt C; Bronson RT; Davisson MT. 1995. A mouse model for Down syndrome exhibits learning and behaviour deficits [see comments] Nat Genet 11(2):177-84. [PubMed: 7550346]  [MGI Ref ID J:29232]

Richtsmeier JT; Baxter LL; Reeves RH. 2000. Parallels of craniofacial maldevelopment in Down syndrome and Ts65Dn mice. Dev Dyn 217(2):137-45. [PubMed: 10706138]  [MGI Ref ID J:60229]

Richtsmeier JT; Zumwalt A; Carlson EJ; Epstein CJ; Reeves RH. 2002. Craniofacial phenotypes in segmentally trisomic mouse models for Down syndrome. Am J Med Genet 107(4):317-24. [PubMed: 11840489]  [MGI Ref ID J:73800]

Roper RJ; Baxter LL; Saran NG; Klinedinst DK; Beachy PA; Reeves RH. 2006. Defective cerebellar response to mitogenic Hedgehog signaling in Down's syndrome mice. Proc Natl Acad Sci U S A 103(5):1452-6. [PubMed: 16432181]  [MGI Ref ID J:105996]

Roper RJ; St John HK; Philip J; Lawler A; Reeves RH. 2006. Perinatal Loss of Ts65Dn Down Syndrome Mice. Genetics 172(1):437-43. [PubMed: 16172497]  [MGI Ref ID J:105157]

Roper RJ; VanHorn JF; Cain CC; Reeves RH. 2009. A neural crest deficit in Down syndrome mice is associated with deficient mitotic response to Sonic hedgehog. Mech Dev 126(3-4):212-9. [PubMed: 19056491]  [MGI Ref ID J:145541]

Rueda N; Florez J; Martinez-Cue C. 2008. Chronic pentylenetetrazole but not donepezil treatment rescues spatial cognition in Ts65Dn mice, a model for Down syndrome. Neurosci Lett 433(1):22-7. [PubMed: 18226451]  [MGI Ref ID J:174272]

Rueda N; Florez J; Martinez-Cue C. 2008. Effects of chronic administration of SGS-111 during adulthood and during the pre- and post-natal periods on the cognitive deficits of Ts65Dn mice, a model of Down syndrome. Behav Brain Res 188(2):355-67. [PubMed: 18178265]  [MGI Ref ID J:131326]

Rueda N; Mostany R; Pazos A; Florez J; Martinez-Cue C. 2005. Cell proliferation is reduced in the dentate gyrus of aged but not young Ts65Dn mice, a model of Down syndrome. Neurosci Lett 380(1-2):197-201. [PubMed: 15854777]  [MGI Ref ID J:97980]

Ruiz de Azua I; Lumbreras MA; Zalduegui A; Baamonde C; Dierssen M; Florez J; Salles J. 2001. Reduced phospholipase C-beta activity and isoform expression in the cerebellum of TS65Dn mouse: a model of Down syndrome. J Neurosci Res 66(4):540-50. [PubMed: 11746373]  [MGI Ref ID J:174277]

Sago H; Carlson EJ; Smith DJ; Rubin EM; Crnic LS; Huang TT; Epstein CJ. 2000. Genetic dissection of region associated with behavioral abnormalities in mouse models for Down syndrome. Pediatr Res 48(5):606-13. [PubMed: 11044479]  [MGI Ref ID J:86822]

Sahir N; Brenneman DE; Hill JM. 2006. Neonatal mice of the Down syndrome model, Ts65Dn, exhibit upregulated VIP measures and reduced responsiveness of cortical astrocytes to VIP stimulation. J Mol Neurosci 30(3):329-40. [PubMed: 17401158]  [MGI Ref ID J:174343]

Salehi A; Delcroix JD; Belichenko PV; Zhan K; Wu C; Valletta JS; Takimoto-Kimura R; Kleschevnikov AM; Sambamurti K; Chung PP; Xia W; Villar A; Campbell WA; Kulnane LS; Nixon RA; Lamb BT; Epstein CJ; Stokin GB; Goldstein LS; Mobley WC. 2006. Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron 51(1):29-42. [PubMed: 16815330]  [MGI Ref ID J:122937]

Salehi A; Faizi M; Colas D; Valletta J; Laguna J; Takimoto-Kimura R; Kleschevnikov A; Wagner SL; Aisen P; Shamloo M; Mobley WC. 2009. Restoration of norepinephrine-modulated contextual memory in a mouse model of Down syndrome. Sci Transl Med 1(7):7ra17. [PubMed: 20368182]  [MGI Ref ID J:167886]

Sanders NC; Williams DK; Wenger GR. 2009. Does the learning deficit observed under an incremental repeated acquisition schedule of reinforcement in Ts65Dn mice, a model for Down syndrome, change as they age? Behav Brain Res 203(1):137-42. [PubMed: 19409933]  [MGI Ref ID J:149835]

Saran NG; Pletcher MT; Natale JE; Cheng Y; Reeves RH. 2003. Global disruption of the cerebellar transcriptome in a Down syndrome mouse model. Hum Mol Genet 12(16):2013-9. [PubMed: 12913072]  [MGI Ref ID J:95709]

Scott-McKean JJ; Chang B; Hurd RE; Nusinowitz S; Schmidt C; Davisson MT; Costa AC. 2010. The mouse model of Down syndrome Ts65Dn presents visual deficits as assessed by pattern visual evoked potentials. Invest Ophthalmol Vis Sci 51(6):3300-8. [PubMed: 20130276]  [MGI Ref ID J:164105]

Seo H; Isacson O. 2005. Abnormal APP, cholinergic and cognitive function in Ts65Dn Down's model mice. Exp Neurol 193(2):469-80. [PubMed: 15869949]  [MGI Ref ID J:99662]

Shetty HU; Siarey RJ; Galdzicki Z; Stoll J; Rapoport SI. 2000. Ts65Dn mouse, a Down syndrome model, exhibits elevated myo-inositol in selected brain regions and peripheral tissues. Neurochem Res 25(4):431-5. [PubMed: 10823574]  [MGI Ref ID J:174335]

Shichiri M; Yoshida Y; Ishida N; Hagihara Y; Iwahashi H; Tamai H; Niki E. 2011. alpha-Tocopherol suppresses lipid peroxidation and behavioral and cognitive impairments in the Ts65Dn mouse model of Down syndrome. Free Radic Biol Med 50(12):1801-11. [PubMed: 21447382]  [MGI Ref ID J:172069]

Siarey RJ; Carlson EJ; Epstein CJ; Balbo A; Rapoport SI; Galdzicki Z. 1999. Increased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome. Neuropharmacology 38(12):1917-20. [PubMed: 10608287]  [MGI Ref ID J:86821]

Siarey RJ; Coan EJ; Rapoport SI; Galdzicki Z. 1997. Responses to NMDA in cultured hippocampal neurons from trisomy 16 embryonic mice. Neurosci Lett 232(3):131-4. [PubMed: 9310297]  [MGI Ref ID J:174280]

Siarey RJ; Kline-Burgess A; Cho M; Balbo A; Best TK; Harashima C; Klann E; Galdzicki Z. 2006. Altered signaling pathways underlying abnormal hippocampal synaptic plasticity in the Ts65Dn mouse model of Down syndrome. J Neurochem 98(4):1266-77. [PubMed: 16895585]  [MGI Ref ID J:119275]

Siarey RJ; Stoll J; Rapoport SI; Galdzicki Z. 1997. Altered long-term potentiation in the young and old Ts65Dn mouse, a model for Down Syndrome. Neuropharmacology 36(11-12):1549-54. [PubMed: 9517425]  [MGI Ref ID J:174279]

Siddiqui A; Lacroix T; Stasko MR; Scott-McKean JJ; Costa AC; Gardiner KJ. 2008. Molecular responses of the Ts65Dn and Ts1Cje mouse models of Down syndrome to MK-801. Genes Brain Behav 7(7):810-20. [PubMed: 19125866]  [MGI Ref ID J:151137]

Spellman C; Ahmed MM; Dubach D; Gardiner KJ. 2013. Expression of trisomic proteins in Down syndrome model systems. Gene 512(2):219-25. [PubMed: 23103828]  [MGI Ref ID J:192164]

Stasko MR; Costa AC. 2004. Experimental parameters affecting the Morris water maze performance of a mouse model of Down syndrome. Behav Brain Res 154(1):1-17. [PubMed: 15302106]  [MGI Ref ID J:95703]

Stasko MR; Scott-McKean JJ; Costa AC. 2006. Hypothermic responses to 8-OH-DPAT in the Ts65Dn mouse model of Down syndrome. Neuroreport 17(8):837-41. [PubMed: 16708025]  [MGI Ref ID J:174341]

Stewart LS; Persinger MA; Cortez MA; Snead OC 3rd. 2007. Chronobiometry of behavioral activity in the Ts65Dn model of Down syndrome. Behav Genet 37(2):388-98. [PubMed: 17146725]  [MGI Ref ID J:147556]

Strovel J; Stamberg J; Yarowsky PJ. 1999. Interphase FISH for rapid identification of a down syndrome animal model. Cytogenet Cell Genet 86(3-4):285-7. [PubMed: 10575227]  [MGI Ref ID J:174278]

Sussan TE; Yang A; Li F; Ostrowski MC; Reeves RH. 2008. Trisomy represses Apc(Min)-mediated tumours in mouse models of Down's syndrome. Nature 451(7174):73-5. [PubMed: 18172498]  [MGI Ref ID J:131046]

Tlili A; Noll C; Middendorp S; Duchon A; Jouan M; Benabou E; Herault Y; Paul JL; Delabar JM; Janel N. 2013. DYRK1A overexpression decreases plasma lecithin:cholesterol acyltransferase activity and apolipoprotein A-I levels. Mol Genet Metab 110(3):371-7. [PubMed: 23920041]  [MGI Ref ID J:205302]

Toiber D; Azkona G; Ben-Ari S; Toran N; Soreq H; Dierssen M. 2010. Engineering DYRK1A overdosage yields Down syndrome-characteristic cortical splicing aberrations. Neurobiol Dis 40(1):348-359. [PubMed: 20600907]  [MGI Ref ID J:163008]

Trazzi S; Mitrugno VM; Valli E; Fuchs C; Rizzi S; Guidi S; Perini G; Bartesaghi R; Ciani E. 2011. APP-dependent up-regulation of Ptch1 underlies proliferation impairment of neural precursors in Down syndrome. Hum Mol Genet 20(8):1560-73. [PubMed: 21266456]  [MGI Ref ID J:170123]

Turner CA; Presti MF; Newman HA; Bugenhagen P; Crnic L; Lewis MH. 2001. Spontaneous stereotypy in an animal model of Down syndrome: Ts65Dn mice. Behav Genet 31(4):393-400. [PubMed: 11720125]  [MGI Ref ID J:72690]

Usowicz MM; Garden CL. 2012. Increased excitability and altered action potential waveform in cerebellar granule neurons of the Ts65Dn mouse model of Down syndrome. Brain Res 1465:10-7. [PubMed: 22627164]  [MGI Ref ID J:186437]

Velazquez R; Ash JA; Powers BE; Kelley CM; Strawderman M; Luscher ZI; Ginsberg SD; Mufson EJ; Strupp BJ. 2013. Maternal choline supplementation improves spatial learning and adult hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome. Neurobiol Dis 58C:92-101. [PubMed: 23643842]  [MGI Ref ID J:197983]

Vidal V; Garcia S; Martinez P; Corrales A; Florez J; Rueda N; Sharma A; Martinez-Cue C. 2012. Lack of behavioral and cognitive effects of chronic ethosuximide and gabapentin treatment in the Ts65Dn mouse model of Down syndrome. Neuroscience 220:158-68. [PubMed: 22728103]  [MGI Ref ID J:192516]

Villar AJ; Belichenko PV; Gillespie AM; Kozy HM; Mobley WC; Epstein CJ. 2005. Identification and characterization of a new Down syndrome model, Ts[Rb(12.1716)]2Cje, resulting from a spontaneous Robertsonian fusion between T(171)65Dn and mouse chromosome 12. Mamm Genome 16(2):79-90. [PubMed: 15859352]  [MGI Ref ID J:96650]

Vorbrodt AW; Li S; Brown WT; Ramakrishna N. 2008. Increased expression of beta-catenin in brain microvessels of a segmentally trisomic (Ts65Dn) mouse model of Down syndrome. Brain Cell Biol 36(5-6):203-11. [PubMed: 19132532]  [MGI Ref ID J:174346]

Voronov SV; Frere SG; Giovedi S; Pollina EA; Borel C; Zhang H; Schmidt C; Akeson EC; Wenk MR; Cimasoni L; Arancio O; Davisson MT; Antonarakis SE; Gardiner K; De Camilli P; Di Paolo G. 2008. Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome. Proc Natl Acad Sci U S A 105(27):9415-20. [PubMed: 18591654]  [MGI Ref ID J:137826]

Wang X; Zhao Y; Zhang X; Badie H; Zhou Y; Mu Y; Loo LS; Cai L; Thompson RC; Yang B; Chen Y; Johnson PF; Wu C; Bu G; Mobley WC; Zhang D; Gage FH; Ranscht B; Zhang YW; Lipton SA; Hong W; Xu H. 2013. Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome. Nat Med 19(4):473-80. [PubMed: 23524343]  [MGI Ref ID J:198375]

Wenger GR; Schmidt C; Davisson MT. 2004. Operant conditioning in the Ts65Dn mouse: learning. Behav Genet 34(1):105-19. [PubMed: 14739701]  [MGI Ref ID J:95708]

Williams AD; Mjaatvedt CH; Moore CS. 2008. Characterization of the cardiac phenotype in neonatal Ts65Dn mice. Dev Dyn 237(2):426-35. [PubMed: 18161058]  [MGI Ref ID J:130989]

Wiseman FK; Alford KA; Tybulewicz VL; Fisher EM. 2009. Down syndrome--recent progress and future prospects. Hum Mol Genet 18(R1):R75-83. [PubMed: 19297404]  [MGI Ref ID J:156661]

Xu JC; Dawson VL; Dawson TM. 2013. Usp16: key controller of stem cells in Down syndrome. EMBO J 32(21):2788-9. [PubMed: 24076652]  [MGI Ref ID J:202008]

Yang A; Reeves RH. 2011. Increased Survival following Tumorigenesis in Ts65Dn Mice That Model Down Syndrome. Cancer Res 71(10):3573-81. [PubMed: 21467166]  [MGI Ref ID J:171978]

Zhang L; Fu D; Belichenko PV; Liu C; Kleschevnikov AM; Pao A; Liang P; Clapcote SJ; Mobley WC; Yu YE. 2012. Genetic analysis of Down syndrome facilitated by mouse chromosome engineering. Bioeng Bugs 3(1):8-12. [PubMed: 22126738]  [MGI Ref ID J:196862]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX11

Colony Maintenance

Mating SystemTs65Dn trisomic female x B6EiC3Sn.BLiAF1 (003647)
See Colony Maintenance for Ts65Dn for additional details.
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $225.00Female or MaleTrisomic for Ts(1716)65Dn  
Price per Pair (US dollars $)Pair Genotype
$350.00Trisomic for Ts(1716)65Dn x B6EiC3Sn.BLiAF1 (003647)  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $292.50Female or MaleTrisomic for Ts(1716)65Dn  
Price per Pair (US dollars $)Pair Genotype
$455.00Trisomic for Ts(1716)65Dn x B6EiC3Sn.BLiAF1 (003647)  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.

General Supply Notes

  • A 10% price increase applied to orders for this strain placed by for-profit companies.

Control Information

  Control
   Wild-type from the colony
   003647 B6EiC3Sn.BLiAF1/J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Strain from the Cytogenetic Models Resource. First time use requires submission of a Request Form, please inquire.

Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


(6.6)