Strain Name:

NODCaj.Cg-Igh-6tm1Cgn Tg(Igh-VB1-8/Igh-6m)1Mjsk/FswJ

Stock Number:

005306

Availability:

Repository-Cryopreserved

Use Restrictions Apply, see Terms of Use
Common Names: NOD.mIgM;    

Description

Strain Information

Former Names NODCaj.Cg-Igh-6tm1Cgn Tg(Igh-VB1-8/Igh-6)1Mjsk/FswJ    (Changed: 17-JUN-05 )
Type Coisogenic; Congenic; Mutant Strain; Targeted Mutation; Transgenic;
Additional information on Genetically Engineered Mutant Mice.
Specieslaboratory mouse
Background Strain NOD/Caj
Donor Strain 129/S2(B6)
H2 Haplotypeg7
GenerationN12F3+F3p (12-FEB-06)
 
Donating InvestigatorDr. F. Susan Wong,   University of Bristol

Appearance
pink-eye, albino
Related Genotype: A/? Tyrc/Tyrc

Description
Transgenic mice carrying the Igh-6tm1Cgn allele are viable, fertile, and normal in size and restores the B220+ B-cells to normal. The number of B-cells is normal and the ratio of CD4 to CD8 is normal. Although only a fraction of the transgenic mice have an increased amount of insulitis, it is more severe, especially in males. Diabetes incidence is partially restored in NODCaj.Cg-Igh-6tm1Cgn Tg(Igh-VB1-8/Igh-6m)1Mjsk/Fsw with approximately, 11% females and 0% males becoming diabetic by 50 weeks of age compared to approximately 2% Igh-6tm1Cgn female controls and 0% Igh-6tm1Cgn male controls by 50 weeks of age or 90% female NOD controls and 70% male NOD controls by 30 weeks of age. T- cell depleted spleen cells from Igh-6tm1Cgn Tg(Igh-VB1-8/Igh-6m)1Mjsk mice stimulated with lipopolysaccharide (LPS) respond normally. NODCaj.Cg-Igh-6tm1Cgn Tg(Igh-VB1-8/Igh-6 )2Mjsk/Fsw like NOD.129S2(B6)-Igh-6tm1Cgn generate low T-cell responses to GAD and insulin.

This model is useful for separating the role of B-cells in antigen presentation from antibody production involved in diabetes development.

Development
The transgenic construct Tg(Igh-VB1-8/Igh-6m)1Mjsk that encodes a membrane bound, but not a secreted, immunoglobulin mu heavy chain, was injected into NOD/Caj zygotes. Founders were backcrossed to NOD/Caj. An outcross-intercross strategy was employed to introduce an inactivated Igh6 allele from NOD.129S2(B6)-Igh-6tm1Cgn. In 2005, the Type 1 Diabetes Resource received NOD/Caj.Cg-Igh-6tm1Cgn Tg(Igh-VB1-8/Igh-6m)1Mjsk/FswJ at generation N12F3.

Control Information

  Control
   Homozygote for Igh-6tm1Cgn, Wildtype for Tg(Igh-VB1-8/Igh-6m)1Mjsk
   005309 NODCaj.Cg-Igh-6tm1Cgn Tg(Igh-VB1-8/Igh-6)2Mjsk/FswJ
 
  Considerations for Choosing Controls

Related Strains

View Strains carrying   Igh-6tm1Cgn     (7 strains)

View Strains carrying other alleles of Igh-6     (6 strains)

View Strains carrying other alleles of Igh-V     (3 strains)

Additional Web Information

Congenic Nomenclature
Genetic Quality Control Annual Report

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms
Diabetes Mellitus, Insulin-Dependent; IDDM - Models with phenotypic similarity to human disease where etiologies are distinct.2
2 Human genes are associated with this disease. Orthologs of those genes do not appear in the mouse genotype(s).
View Mammalian Phenotype Terms

Mammalian Phenotype Terms
      assigned by genotype

Igh-6tm1Cgn/Igh-6tm1Cgn Tg(Igh-VB1-8/Igh-6m)1Mjsk/?

        NODCaj.Cg-Igh-6tm1Cgn Tg(Igh-VB1-8/Igh-6m)1Mjsk/FswJ
  • immune system phenotype
  • increased susceptibility to autoimmune diabetes (MGI Ref ID J:93190)
    • female Igh-6-deficient transgenic mice show a 7-fold increase in the incidence of (blood glucose >250 mg/dl) diabetes compared with nontransgenic littermates
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Diabetes and Obesity Research
Type 1 Diabetes (IDDM)
Type 1 Diabetes (IDDM) Analysis Strains (NOD Congenics with Mutations Affecting Immunocompetence)
Type 1 Diabetes (IDDM) Analysis Strains (NOD Transgenics)

Immunology and Inflammation Research
Autoimmunity (B cell deficiency)
Autoimmunity (Type 1 Diabetes)
Immunodeficiency (B cell defects)

Igh-6tm1Cgn related

Immunology and Inflammation Research
Immunodeficiency (B cell deficiency)

Research Tools
Cancer Research (B cell deficiency)
Immunology and Inflammation Research (B cell deficiency)

Genes & Alleles

Gene & Allele Information

Allele Symbol Igh-6tm1Cgn
Allele Name targeted mutation 1, University of Cologne
Allele Type Targeted (knock-out)
Common Name(s) BCR-; BKO; Cmu <->; Ig- muMT; Ig-; IgH-; IgHmuMT; Igh-6-; Igh-6null; Igmunull; mu-MT-; muMT; muMt-; mum-;
Mutation Made By Daisuke Kitamura,   University of Cologne
Strain of Origin129S2/SvPas
ES Cell Line NameD3
ES Cell Line Strain129S2/SvPas
Gene Symbol and Name Igh-6, immunoglobulin heavy chain 6 (heavy chain of IgM)
Chromosome 12
Gene Common Name(s) AI326478; BCR; DKFZp686I15196; DKFZp686I15212; FLJ00385; Ig mu; IgM; Igh-M; Igh6; MGC104996; MGC52291; MU; VH; expressed sequence AI326478; immunoglobulin heavy chain mu; muH; muMT;
Molecular Note A neomycin resistance cassette disrupted one of the membrane exons of the gene encoding immunoglobulin heavy chain of the class mu (IgM). [MGI Ref ID J:110548] [MGI Ref ID J:70398]
 
Allele Symbol Tg(Igh-VB1-8/Igh-6m)1Mjsk
Allele Name transgene insertion 1, Mark J Shlomchik
Allele Type Transgenic (random, expressed)
Common Name(s) Tg(Igh-VB1-8/Igh-6)1Mjsk; mIg;
Mutation Made By Mark Shlomchik,   Yale School of Medicine
Strain of OriginNOD/Caj
Expressed Gene Igh-V, immunoglobulin heavy chain variable region, mouse, laboratory
Expressed Gene Igh-6, immunoglobulin heavy chain 6 (heavy chain of IgM), mouse, laboratory
Molecular Note The transgene encodes a membrane-bound, but not a secreted, immunoglobulin mu heavy chain. The variable region of the transgene comprises the VDJ moiety from the functionally rearranged Igh gene of the C57BL/6-derived B1-8 hybridoma, containing the V-region segment Vh186.2 and recognizing the hapten (4-hydroxy-3-nitrophenyl)acetyl. This is followed by a J-C intron fragment containing the Igh intronic enhancer and an Igh-6 constant region gene (of haplotype a) from which the exon encoding the secreted form of Igmu and its associated polyadenylation signal have been deleted. [MGI Ref ID J:55066]

Genotyping

Genotyping Information

Genotyping Protocols

Igh-6tm1Cgn, STD PCR, vers. 1

Helpful Links

Optimizing PCR Protocols

References

References

Selected Reference(s)

Wong FS; Wen L; Tang M; Ramanathan M; Visintin I; Daugherty J; Hannum LG; Janeway CA Jr; Shlomchik MJ. 2004. Investigation of the role of B-cells in type 1 diabetes in the NOD mouse. Diabetes 53(10):2581-7. [PubMed: 15448087]  [MGI Ref ID J:93190]

Additional References

Igh-6tm1Cgn related

Abraham D; Leon O; Schnyder-Candrian S; Wang CC; Galioto AM; Kerepesi LA; Lee JJ; Lustigman S. 2004. Immunoglobulin E and eosinophil-dependent protective immunity to larval Onchocerca volvulus in mice immunized with irradiated larvae. Infect Immun 72(2):810-7. [PubMed: 14742524]  [MGI Ref ID J:87861]

Akashi T; Nagafuchi S; Anzai K; Kitamura D; Wang J; Taniuchi I; Niho Y; Watanabe T. 1998. Proliferation of CD3+ B220- single-positive normal T cells was suppressed in B-cell-deficient lpr mice. Immunology 93(2):238-48. [PubMed: 9616374]  [MGI Ref ID J:45808]

Ali M; Weinreich M; Balcaitis S; Cooper CJ; Fink PJ. 2003. Differential regulation of peripheral CD4+ T cell tolerance induced by deletion and TCR revision. J Immunol 171(11):6290-6. [PubMed: 14634147]  [MGI Ref ID J:132828]

Allen HL; Deepe GS Jr. 2006. B cells and CD4-CD8- T cells are key regulators of the severity of reactivation histoplasmosis. J Immunol 177(3):1763-71. [PubMed: 16849486]  [MGI Ref ID J:138028]

Alpan O; Rudomen G; Matzinger P. 2001. The role of dendritic cells, B cells, and M cells in gut-oriented immune responses. J Immunol 166(8):4843-52. [PubMed: 11290760]  [MGI Ref ID J:68620]

Andersen C; Jensen T; Nansen A; Marker O; Thomsen AR. 1999. CD4(+) T cell-mediated protection against a lethal outcome of systemic infection with vesicular stomatitis virus requires CD40 ligand expression, but not IFN-gamma or IL-4. Int Immunol 11(12):2035-42. [PubMed: 10590269]  [MGI Ref ID J:110491]

Andoh M; Zhang G; Russell-Lodrigue KE; Shive HR; Weeks BR; Samuel JE. 2007. T Cells Are Essential for Bacterial Clearance, and Gamma Interferon, Tumor Necrosis Factor Alpha, and B Cells Are Crucial for Disease Development in Coxiella burnetii Infection in Mice. Infect Immun 75(7):3245-55. [PubMed: 17438029]  [MGI Ref ID J:122426]

Andreansky S; Liu H; Adler H; Koszinowski UH; Efstathiou S; Doherty PC. 2004. The limits of protection by 'memory' T cells in Ig-/- mice persistently infected with a gamma-herpesvirus. Proc Natl Acad Sci U S A 101(7):2017-22. [PubMed: 14764895]  [MGI Ref ID J:88442]

Angeli V; Ginhoux F; Llodra J; Quemeneur L; Frenette PS; Skobe M; Jessberger R; Merad M; Randolph GJ. 2006. B cell-driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization. Immunity 24(2):203-15. [PubMed: 16473832]  [MGI Ref ID J:113320]

Aroeira LS; Mouton CG; Toran JL; Ward ES; Martinez C. 1999. Anti-Vbeta8 antibodies induce and maintain staphylococcal enterotoxin B-triggered Vbeta8+ T cell anergy. Eur J Immunol 29(2):437-45. [PubMed: 10064059]  [MGI Ref ID J:115226]

Arras M; Louahed J; Heilier JF; Delos M; Brombacher F; Renauld JC; Lison D; Huaux F. 2005. IL-9 protects against bleomycin-induced lung injury: involvement of prostaglandins. Am J Pathol 166(1):107-15. [PubMed: 15632004]  [MGI Ref ID J:95244]

Arras M; Louahed J; Simoen V; Barbarin V; Misson P; van den Brule S; Delos M; Knoops L; Renauld JC; Lison D; Huaux F. 2006. B lymphocytes are critical for lung fibrosis control and prostaglandin E2 regulation in IL-9 transgenic mice. Am J Respir Cell Mol Biol 34(5):573-80. [PubMed: 16424385]  [MGI Ref ID J:136512]

Asano MS; Ahmed R. 1996. CD8 T cell memory in B cell-deficient mice. J Exp Med 183(5):2165-74. [PubMed: 8642326]  [MGI Ref ID J:33136]

Ashour HM; Niederkorn JY. 2006. Peripheral tolerance via the anterior chamber of the eye: role of B cells in MHC class I and II antigen presentation. J Immunol 176(10):5950-7. [PubMed: 16670303]  [MGI Ref ID J:131707]

Aurora AB; Baluk P; Zhang D; Sidhu SS; Dolganov GM; Basbaum C; McDonald DM; Killeen N. 2005. Immune complex-dependent remodeling of the airway vasculature in response to a chronic bacterial infection. J Immunol 175(10):6319-26. [PubMed: 16272283]  [MGI Ref ID J:119344]

Baumgarth N; Jager GC; Herman OC; Herzenberg LA. 2000. CD4+ T cells derived from B cell-deficient mice inhibit the establishment of peripheral B cell pools. Proc Natl Acad Sci U S A 97(9):4766-71. [PubMed: 10781082]  [MGI Ref ID J:61947]

Beland JL; Sobel RA; Adler H; Del-Pan NC; Rimm IJ. 1999. B cell-deficient mice have increased susceptibility to HSV-1 encephalomyelitis and mortality. J Neuroimmunol 94(1-2):122-6. [PubMed: 10376944]  [MGI Ref ID J:102971]

Belperron AA; Bockenstedt LK. 2001. Natural Antibody Affects Survival of the Spirochete Borrelia burgdorferi within Feeding Ticks. Infect Immun 69(10):6456-62. [PubMed: 11553590]  [MGI Ref ID J:71569]

Bergmann CC; Ramakrishna C; Kornacki M; Stohlman SA. 2001. Impaired T cell immunity in B cell-deficient mice following viral central nervous system infection. J Immunol 167(3):1575-83. [PubMed: 11466379]  [MGI Ref ID J:120484]

Beutner U; Kraus E; Kitamura D; Rajewsky K; Huber BT. 1994. B cells are essential for murine mammary tumor virus transmission, but not for presentation of endogenous superantigens. J Exp Med 179(5):1457-66. [PubMed: 8163931]  [MGI Ref ID J:110774]

Bhattacharya D; Rossi DJ; Bryder D; Weissman IL. 2006. Purified hematopoietic stem cell engraftment of rare niches corrects severe lymphoid deficiencies without host conditioning. J Exp Med 203(1):73-85. [PubMed: 16380511]  [MGI Ref ID J:118834]

Binder GK; Griffin DE. 2001. Interferon-gamma-mediated site-specific clearance of alphavirus from CNS neurons. Science 293(5528):303-6. [PubMed: 11452126]  [MGI Ref ID J:125465]

Bitsaktsis C; Nandi B; Racine R; MacNamara KC; Winslow G. 2007. T-Cell-independent humoral immunity is sufficient for protection against fatal intracellular ehrlichia infection. Infect Immun 75(10):4933-41. [PubMed: 17664264]  [MGI Ref ID J:125283]

Bommireddy R; Engle SJ; Ormsby I; Boivin GP; Babcock GF; Doetschman T. 2004. Elimination of both CD4(+) and CD8(+) T cells but not B cells eliminates inflammation and prolongs the survival of TGFbeta1-deficient mice. Cell Immunol 232(1-2):96-104. [PubMed: 15922720]  [MGI Ref ID J:99033]

Borchers MT; Crosby J; Justice P; Farmer S; Hines E; Lee JJ; Lee NA. 2001. Intrinsic AHR in IL-5 transgenic mice is dependent on CD4(+) cells and CD49d-mediated signaling. Am J Physiol Lung Cell Mol Physiol 281(3):L653-9. [PubMed: 11504693]  [MGI Ref ID J:132284]

Borenstein SH; Graham J; Zhang XL; Chamberlain JW. 2000. CD8+ T cells are necessary for recognition of allelic, but not locus-mismatched or xeno-, HLA class I transplantation antigens. J Immunol 165(5):2341-53. [PubMed: 10946256]  [MGI Ref ID J:80678]

Bosio CM; Elkins KL. 2001. Susceptibility to secondary Francisella tularensis live vaccine strain infection in B-cell-deficient mice is associated with neutrophilia but not with defects in specific T-cell-mediated immunity. Infect Immun 69(1):194-203. [PubMed: 11119506]  [MGI Ref ID J:67757]

Bowne WB; Srinivasan R; Wolchok JD; Hawkins WG; Blachere NE; Dyall R; Lewis JJ; Houghton AN. 1999. Coupling and uncoupling of tumor immunity and autoimmunity. J Exp Med 190(11):1717-22. [PubMed: 10587362]  [MGI Ref ID J:115120]

Braley-Mullen H; Yu S. 2000. Early requirement for B cells for development of spontaneous autoimmune thyroiditis in NOD.H-2h4 mice J Immunol 165(12):7262-9. [PubMed: 11120860]  [MGI Ref ID J:66106]

Brodie GM; Wallberg M; Santamaria P; Wong FS; Green EA. 2008. B-cells promote intra-islet CD8+ cytotoxic T-cell survival to enhance type 1 diabetes. Diabetes 57(4):909-17. [PubMed: 18184927]  [MGI Ref ID J:135342]

Brundler MA; Aichele P; Bachmann M; Kitamura D; Rajewsky K; Zinkernagel RM. 1996. Immunity to viruses in B cell-deficient mice: influence of antibodies on virus persistence and on T cell memory. Eur J Immunol 26(9):2257-62. [PubMed: 8814275]  [MGI Ref ID J:112980]

Bry L; Brenner MB. 2004. Critical role of T cell-dependent serum antibody, but not the gut-associated lymphoid tissue, for surviving acute mucosal infection with Citrobacter rodentium, an attaching and effacing pathogen. J Immunol 172(1):433-41. [PubMed: 14688352]  [MGI Ref ID J:87077]

Burne-Taney MJ; Ascon DB; Daniels F; Racusen L; Baldwin W; Rabb H. 2003. B cell deficiency confers protection from renal ischemia reperfusion injury. J Immunol 171(6):3210-5. [PubMed: 12960350]  [MGI Ref ID J:85388]

Ceredig R; Andersson J; Melchers F; Rolink A. 1999. Effect of deregulated IL-7 transgene expression on B lymphocyte development in mice expressing mutated pre-B cell receptors. Eur J Immunol 29(9):2797-807. [PubMed: 10508254]  [MGI Ref ID J:57690]

Cernetich A; Garver LS; Jedlicka AE; Klein PW; Kumar N; Scott AL; Klein SL. 2006. Involvement of gonadal steroids and gamma interferon in sex differences in response to blood-stage malaria infection. Infect Immun 74(6):3190-203. [PubMed: 16714546]  [MGI Ref ID J:109239]

Chan OT; Hannum LG; Haberman AM; Madaio MP; Shlomchik MJ. 1999. A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus. J Exp Med 189(10):1639-48. [PubMed: 10330443]  [MGI Ref ID J:55066]

Chao TK; Rifai A; Ka SM; Yang SM; Shui HA; Lin YF; Sytwu HK; Lee WH; Kung JT; Chen A. 2006. The endogenous immune response modulates the course of IgA-immune complex mediated nephropathy. Kidney Int 70(2):283-97. [PubMed: 16738538]  [MGI Ref ID J:136494]

Chen YG; Silveira PA; Osborne MA; Chapman HD; Serreze DV. 2007. Cellular expression requirements for inhibition of type 1 diabetes by a dominantly protective major histocompatibility complex haplotype. Diabetes 56(2):424-30. [PubMed: 17259387]  [MGI Ref ID J:121957]

Chen Z; Yu S; Concha HQ; Zhu Y; Mix E; Winblad B; Ljunggren HG; Zhu J. 2004. Kainic acid-induced excitotoxic hippocampal neurodegeneration in C57BL/6 mice: B cell and T cell subsets may contribute differently to the pathogenesis. Brain Behav Immun 18(2):175-85. [PubMed: 14759595]  [MGI Ref ID J:105331]

Chiarle R; Martinengo C; Mastini C; Ambrogio C; D'Escamard V; Forni G; Inghirami G. 2008. The anaplastic lymphoma kinase is an effective oncoantigen for lymphoma vaccination. Nat Med 14(6):676-80. [PubMed: 18469826]  [MGI Ref ID J:136968]

Christensen JP; Cardin RD; Branum KC; Doherty PC. 1999. CD4(+) T cell-mediated control of a gamma-herpesvirus in B cell- deficient mice is mediated by IFN-gamma. Proc Natl Acad Sci U S A 96(9):5135-40. [PubMed: 10220431]  [MGI Ref ID J:54884]

Christensen JP; Kauffmann SO; Thomsen AR. 2003. Deficient CD4+ T cell priming and regression of CD8+ T cell functionality in virus-infected mice lacking a normal B cell compartment. J Immunol 171(9):4733-41. [PubMed: 14568949]  [MGI Ref ID J:117991]

Compton SR; Ball-Goodrich LJ; Johnson LK; Johnson EA; Paturzo FX; Macy JD. 2004. Pathogenesis of enterotropic mouse hepatitis virus in immunocompetent and immunodeficient mice. Comp Med 54(6):681-9. [PubMed: 15679267]  [MGI Ref ID J:96019]

Corcoran AE; Riddell A; Krooshoop D; Venkitaraman AR. 1998. Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor. Nature 391(6670):904-7. [PubMed: 9495344]  [MGI Ref ID J:46133]

Coro ES; Chang WL; Baumgarth N. 2006. Type I IFN receptor signals directly stimulate local B cells early following influenza virus infection. J Immunol 176(7):4343-51. [PubMed: 16547272]  [MGI Ref ID J:129867]

Crawford A; Macleod M; Schumacher T; Corlett L; Gray D. 2006. Primary T cell expansion and differentiation in vivo requires antigen presentation by B cells. J Immunol 176(6):3498-506. [PubMed: 16517718]  [MGI Ref ID J:129511]

Croci S; Nicoletti G; Landuzzi L; De Giovanni C; Astolfi A; Marini C; Di Carlo E; Musiani P; Forni G; Nanni P; Lollini PL. 2004. Immunological prevention of a multigene cancer syndrome. Cancer Res 64(22):8428-34. [PubMed: 15548714]  [MGI Ref ID J:93904]

Crosby JR; Cieslewicz G; Borchers M; Hines E; Carrigan P; Lee JJ; Lee NA. 2002. Early phase bronchoconstriction in the mouse requires allergen-specific IgG. J Immunol 168(8):4050-4. [PubMed: 11937563]  [MGI Ref ID J:125656]

Crowley MT; Reilly CR; Lo D. 1999. Influence of lymphocytes on the presence and organization of dendritic cell subsets in the spleen. J Immunol 163(9):4894-900. [PubMed: 10528191]  [MGI Ref ID J:118436]

Croxford JL; Miyake S; Huang YY; Shimamura M; Yamamura T. 2006. Invariant V(alpha)19i T cells regulate autoimmune inflammation. Nat Immunol 7(9):987-94. [PubMed: 16878136]  [MGI Ref ID J:112657]

Cunningham AF; Fallon PG; Khan M; Vacheron S; Acha-Orbea H; MacLennan IC; McKenzie AN; Toellner KM. 2002. Th2 activities induced during virgin T cell priming in the absence of IL-4, IL-13, and B cells. J Immunol 169(6):2900-6. [PubMed: 12218103]  [MGI Ref ID J:120432]

D'Orazio TJ; Mayhew E; Niederkorn JY. 2001. Ocular immune privilege promoted by the presentation of peptide on tolerogenic B cells in the spleen. II. Evidence for presentation by Qa-1 J Immunol 166(1):26-32. [PubMed: 11123273]  [MGI Ref ID J:66404]

Dai WJ; Waldvogel A; Siles-Lucas M; Gottstein B. 2004. Echinococcus multilocularis proliferation in mice and respective parasite 14-3-3 gene expression is mainly controlled by an alphabeta CD4 T-cell-mediated immune response. Immunology 112(3):481-8. [PubMed: 15196217]  [MGI Ref ID J:90911]

Daly J; Licence S; Nanou A; Morgan G; Martensson IL. 2007. Transcription of productive and nonproductive VDJ-recombined alleles after IgH allelic exclusion. EMBO J 26(19):4273-82. [PubMed: 17805345]  [MGI Ref ID J:128011]

Dautigny N; Le Campion A; Lucas B. 1999. Timing and casting for actors of thymic negative selection. J Immunol 162(3):1294-302. [PubMed: 9973382]  [MGI Ref ID J:124433]

Davidson NJ; Leach MW; Fort MM; Thompson-Snipes L; Kuhn R; Muller W; Berg DJ; Rennick DM. 1996. T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice. J Exp Med 184(1):241-51. [PubMed: 8691138]  [MGI Ref ID J:34035]

Deshpande SP; Zheng M; Daheshia M; Rouse BT. 2000. Pathogenesis of herpes simplex virus-induced ocular immunoinflammatory lesions in B-cell-deficient mice. J Virol 74(8):3517-24. [PubMed: 10729125]  [MGI Ref ID J:126865]

Devoss JJ; Shum AK; Johannes KP; Lu W; Krawisz AK; Wang P; Yang T; Leclair NP; Austin C; Strauss EC; Anderson MS. 2008. Effector mechanisms of the autoimmune syndrome in the murine model of autoimmune polyglandular syndrome type 1. J Immunol 181(6):4072-9. [PubMed: 18768863]  [MGI Ref ID J:139094]

Di Rosa F; Matzinger P. 1996. Long-lasting CD8 T cell memory in the absence of CD4 T cells or B cells. J Exp Med 183(5):2153-63. [PubMed: 8642325]  [MGI Ref ID J:110690]

Diaz-de-Durana Y; Mantchev GT; Bram RJ; Franco A. 2006. TACI-BLyS signaling via B-cell-dendritic cell cooperation is required for naive CD8+ T-cell priming in vivo. Blood 107(2):594-601. [PubMed: 16195331]  [MGI Ref ID J:126637]

Dittel BN; Urbania TH; Janeway CA Jr. 2000. Relapsing and remitting experimental autoimmune encephalomyelitis in B cell deficient mice J Autoimmun 14(4):311-8. [PubMed: 10882057]  [MGI Ref ID J:62703]

Ehlich A; Schaal S; Gu H; Kitamura D; Muller W; Rajewsky K. 1993. Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development. Cell 72(5):695-704. [PubMed: 8453664]  [MGI Ref ID J:112992]

Endres R; Alimzhanov MB; Plitz T; Futterer A; Kosco-Vilbois MH; Nedospasov SA; Rajewsky K; Pfeffer K. 1999. Mature follicular dendritic cell networks depend on expression of lymphotoxin beta receptor by radioresistant stromal cells and of lymphotoxin beta and tumor necrosis factor by B cells. J Exp Med 189(1):159-68. [PubMed: 9874572]  [MGI Ref ID J:119173]

Enzler T; Bonizzi G; Silverman GJ; Otero DC; Widhopf GF; Anzelon-Mills A; Rickert RC; Karin M. 2006. Alternative and classical NF-kappa B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like disease. Immunity 25(3):403-15. [PubMed: 16973390]  [MGI Ref ID J:113556]

Eperon S; Bronnimann K; Hemphill A; Gottstein B. 1999. Susceptibility of B-cell deficient C57BL/6 (microMT) mice to Neospora caninum infection. Parasite Immunol 21(5):225-36. [PubMed: 10320620]  [MGI Ref ID J:57441]

Eriksson U; Kurrer MO; Schmitz N; Marsch SC; Fontana A; Eugster HP; Kopf M. 2003. Interleukin-6-deficient mice resist development of autoimmune myocarditis associated with impaired upregulation of complement C3. Circulation 107(2):320-5. [PubMed: 12538435]  [MGI Ref ID J:103083]

Espinoza CR; Feeney AJ. 2005. The extent of histone acetylation correlates with the differential rearrangement frequency of individual VH genes in pro-B cells. J Immunol 175(10):6668-75. [PubMed: 16272322]  [MGI Ref ID J:119390]

Falcone M; Lee J; Patstone G; Yeung B; Sarvetnick N. 1998. B lymphocytes are crucial antigen-presenting cells in the pathogenic autoimmune response to GAD65 antigen in nonobese diabetic mice. J Immunol 161(3):1163-8. [PubMed: 9686575]  [MGI Ref ID J:48878]

Fallah-Arani F; Schweighoffer E; Vanes L; Tybulewicz VL. 2008. Redundant role for Zap70 in B cell development and activation. Eur J Immunol 38(6):1721-33. [PubMed: 18465772]  [MGI Ref ID J:136323]

Fang H; Aosai F; Mun HS; Norose K; Ahmed AK; Furuya M; Yano A. 2006. Anaphylactic reaction induced by Toxoplasma gondii-derived heat shock protein 70. Int Immunol 18(10):1487-97. [PubMed: 16943259]  [MGI Ref ID J:112840]

Fang M; Sigal LJ. 2005. Antibodies and CD8+ T cells are complementary and essential for natural resistance to a highly lethal cytopathic virus. J Immunol 175(10):6829-36. [PubMed: 16272340]  [MGI Ref ID J:119697]

Fillatreau S; Gray D. 2003. T cell accumulation in B cell follicles is regulated by dendritic cells and is independent of B cell activation. J Exp Med 197(2):195-206. [PubMed: 12538659]  [MGI Ref ID J:124822]

Finkelman FD; Morris SC; Orekhova T; Mori M; Donaldson D; Reiner SL; Reilly NL; Schopf L; Urban JF Jr. 2000. Stat6 regulation of in vivo IL-4 responses. J Immunol 164(5):2303-10. [PubMed: 10679064]  [MGI Ref ID J:112038]

Fu YX; Huang G; Wang Y; Chaplin DD. 1998. B lymphocytes induce the formation of follicular dendritic cell clusters in a lymphotoxin alpha-dependent fashion. J Exp Med 187(7):1009-18. [PubMed: 9529317]  [MGI Ref ID J:118756]

Fu YX; Huang G; Wang Y; Chaplin DD. 2000. Lymphotoxin-alpha-dependent spleen microenvironment supports the generation of memory B cells and is required for their subsequent antigen-induced activation. J Immunol 164(5):2508-14. [PubMed: 10679088]  [MGI Ref ID J:126988]

Gallagher E; Enzler T; Matsuzawa A; Anzelon-Mills A; Otero D; Holzer R; Janssen E; Gao M; Karin M. 2007. Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production. Nat Immunol 8(1):57-63. [PubMed: 17143273]  [MGI Ref ID J:116622]

Gaspal F; Bekiaris V; Kim MY; Withers DR; Bobat S; Maclennan IC; Anderson G; Lane PJ; Cunningham AF. 2008. Critical Synergy of CD30 and OX40 Signals in CD4 T Cell Homeostasis and Th1 Immunity to Salmonella. J Immunol 180(5):2824-9. [PubMed: 18292503]  [MGI Ref ID J:131533]

Gelderblom H; Schmidt J; Londono D; Bai Y; Quandt J; Hornung R; Marques A; Martin R; Cadavid D. 2007. Role of interleukin 10 during persistent infection with the relapsing fever Spirochete Borrelia turicatae. Am J Pathol 170(1):251-62. [PubMed: 17200198]  [MGI Ref ID J:117201]

Golovkina TV; Shlomchik M; Hannum L; Chervonsky A. 1999. Organogenic role of B lymphocytes in mucosal immunity. Science 286(5446):1965-8. [PubMed: 10583962]  [MGI Ref ID J:124532]

Gonnella PA; Waldner HP; Weiner HL. 2001. B cell-deficient (mu MT) mice have alterations in the cytokine microenvironment of the gut-associated lymphoid tissue (GALT) and a defect in the low dose mechanism of oral tolerance. J Immunol 166(7):4456-64. [PubMed: 11254701]  [MGI Ref ID J:128579]

Gonzalez A; Andre-Schmutz I; Carnaud C; Mathis D; Benoist C. 2001. Damage control, rather than unresponsiveness, effected by protective DX5+ T cells in autoimmune diabetes. Nat Immunol 2(12):1117-25. [PubMed: 11713466]  [MGI Ref ID J:109860]

Gorbachev AV; Fairchild RL. 2004. CD40 engagement enhances antigen-presenting langerhans cell priming of IFN-gamma-producing CD4+ and CD8+ T cells independently of IL-12. J Immunol 173(4):2443-52. [PubMed: 15294958]  [MGI Ref ID J:92689]

Gramaglia I; Sahlin H; Nolan JP; Frangos JA; Intaglietta M; van der Heyde HC. 2005. Cell- rather than antibody-mediated immunity leads to the development of profound thrombocytopenia during experimental Plasmodium berghei malaria. J Immunol 175(11):7699-707. [PubMed: 16301680]  [MGI Ref ID J:122163]

Gray CA; Lawrence RA. 2002. A role for antibody and Fc receptor in the clearance of Brugia malayi microfilariae. Eur J Immunol 32(4):1114-20. [PubMed: 11920579]  [MGI Ref ID J:115364]

Guleria I; Gubbels Bupp M; Dada S; Fife B; Tang Q; Ansari MJ; Trikudanathan S; Vadivel N; Fiorina P; Yagita H; Azuma M; Atkinson M; Bluestone JA; Sayegh MH. 2007. Mechanisms of PDL1-mediated regulation of autoimmune diabetes. Clin Immunol 125(1):16-25. [PubMed: 17627890]  [MGI Ref ID J:125272]

Hall LR; Lass JH; Diaconu E; Strine ER; Pearlman E. 1999. An essential role for antibody in neutrophil and eosinophil recruitment to the cornea: B cell-deficient (microMT) mice fail to develop Th2-dependent, helminth-mediated keratitis. J Immunol 163(9):4970-5. [PubMed: 10528201]  [MGI Ref ID J:58177]

Hamano Y; Arase H; Saisho H; Saito T. 2000. Immune complex and Fc receptor-mediated augmentation of antigen presentation for in vivo Th cell responses. J Immunol 164(12):6113-9. [PubMed: 10843660]  [MGI Ref ID J:112160]

Hamelmann E; Tadeda K; Oshiba A; Gelfand EW. 1999. Role of IgE in the development of allergic airway inflammation and airway hyper-responsiveness--a murine model. Allergy 54(4):297-305. [PubMed: 10371087]  [MGI Ref ID J:55296]

Hamelmann E; Takeda K; Schwarze J; Vella AT; Irvin CG; Gelfand EW. 1999. Development of eosinophilic airway inflammation and airway hyperresponsiveness requires interleukin-5 but not immunoglobulin E or B lymphocytes. Am J Respir Cell Mol Biol 21(4):480-9. [PubMed: 10502558]  [MGI Ref ID J:114163]

Hamelmann E; Vella AT; Oshiba A; Kappler JW; Marrack P; Gelfand EW. 1997. Allergic airway sensitization induces T cell activation but not airway hyperresponsiveness in B cell-deficient mice. Proc Natl Acad Sci U S A 94(4):1350-5. [PubMed: 9037056]  [MGI Ref ID J:38611]

Hansson AS; Johannesson M; Svensson L; Nandakumar KS; Heinegard D; Holmdahl R. 2004. Relapsing polychondritis, induced in mice with matrilin 1, is an antibody- and complement-dependent disease. Am J Pathol 164(3):959-66. [PubMed: 14982849]  [MGI Ref ID J:88438]

Harder KW; Quilici C; Naik E; Inglese M; Kountouri N; Turner A; Zlatic K; Tarlinton DM; Hibbs ML. 2004. Perturbed myelo/erythropoiesis in Lyn-deficient mice is similar to that in mice lacking the inhibitory phosphatases SHP-1 and SHIP-1. Blood 104(13):3901-10. [PubMed: 15339845]  [MGI Ref ID J:95291]

Harvill ET; Osorio M; Loving CL; Lee GM; Kelly VK; Merkel TJ. 2008. Anamnestic protective immunity to Bacillus anthracis is antibody mediated but independent of complement and Fc receptors. Infect Immun 76(5):2177-82. [PubMed: 18316379]  [MGI Ref ID J:134474]

Hasan M; Polic B; Bralic M; Jonjic S; Rajewsky K. 2002. Incomplete block of B cell development and immunoglobulin production in mice carrying the muMT mutation on the BALB/c background. Eur J Immunol 32(12):3463-71. [PubMed: 12442328]  [MGI Ref ID J:80853]

Hayward SL; Bautista-Lopez N; Suzuki K; Atrazhev A; Dickie P; Elliott JF. 2006. CD4 T cells play major effector role and CD8 T cells initiating role in spontaneous autoimmune myocarditis of HLA-DQ8 transgenic IAb knockout nonobese diabetic mice. J Immunol 176(12):7715-25. [PubMed: 16751419]  [MGI Ref ID J:113267]

Heidari S; Berke Z; Berglof A; Woldegiorgis A; Smith CI; Dalianis T. 1999. Susceptibility to polyoma virus tumorigenesis in X-linked immunodeficient (XID) and B-cell deficient (microMT) mice is not increased In Vivo 13(6):439-44. [PubMed: 10757034]  [MGI Ref ID J:62004]

Heltemes-Harris L; Liu X; Manser T. 2005. An antibody VH gene that promotes marginal zone B cell development and heavy chain allelic inclusion. Int Immunol 17(11):1447-61. [PubMed: 16204304]  [MGI Ref ID J:102308]

Hida S; Ogasawara K; Sato K; Abe M; Takayanagi H; Yokochi T; Sato T; Hirose S; Shirai T; Taki S; Taniguchi T. 2000. CD8(+) T cell-mediated skin disease in mice lacking IRF-2, the transcriptional attenuator of interferon-alpha/beta signaling Immunity 13(5):643-55. [PubMed: 11114377]  [MGI Ref ID J:66034]

Hjelmstrom P; Juedes AE; Fjell J; Ruddle NH. 1998. B-cell-deficient mice develop experimental allergic encephalomyelitis with demyelination after myelin oligodendrocyte glycoprotein sensitization. J Immunol 161(9):4480-3. [PubMed: 9794370]  [MGI Ref ID J:50445]

Holz A; Dyrberg T; Hagopian W; Homann D; von Herrath M; Oldstone MB. 2000. Neither B lymphocytes nor antibodies directed against self antigens of the islets of Langerhans are required for development of virus-induced autoimmune diabetes. J Immunol 165(10):5945-53. [PubMed: 11067957]  [MGI Ref ID J:118383]

Homann D; Tishon A; Berger DP; Weigle WO; von Herrath MG; Oldstone MB. 1998. Evidence for an underlying CD4 helper and CD8 T-cell defect in B-cell-deficient mice: failure to clear persistent virus infection after adoptive immunotherapy with virus-specific memory cells from muMT/muMT mice. J Virol 72(11):9208-16. [PubMed: 9765468]  [MGI Ref ID J:50406]

Horowitz MC; Xi Y; Pflugh DL; Hesslein DG; Schatz DG; Lorenzo JA; Bothwell AL. 2004. Pax5-deficient mice exhibit early onset osteopenia with increased osteoclast progenitors. J Immunol 173(11):6583-91. [PubMed: 15557148]  [MGI Ref ID J:94372]

Hulbert C; Riseili B; Rojas M; Thomas JW. 2001. B cell specificity contributes to the outcome of diabetes in nonobese diabetic mice. J Immunol 167(10):5535-8. [PubMed: 11698422]  [MGI Ref ID J:91865]

Inoue S; Leitner WW; Golding B; Scott D. 2006. Inhibitory effects of B cells on antitumor immunity. Cancer Res 66(15):7741-7. [PubMed: 16885377]  [MGI Ref ID J:112103]

Itakura A; Szczepanik M; Campos RA; Paliwal V; Majewska M; Matsuda H; Takatsu K; Askenase PW. 2005. An hour after immunization peritoneal B-1 cells are activated to migrate to lymphoid organs where within 1 day they produce IgM antibodies that initiate elicitation of contact sensitivity. J Immunol 175(11):7170-8. [PubMed: 16301620]  [MGI Ref ID J:122149]

Izcue A; Morales G; Minguet S; Sanchez-Movilla A; Morales P; Martinez-M JA; Gaspar ML; Marcos MA. 2001. Both B and gamma delta TCR(+) lymphocytes regulate alpha beta TCR(+) lymphocytes involved in superantigen specific responses. Eur J Immunol 31(9):2811-7. [PubMed: 11536180]  [MGI Ref ID J:71673]

Jankovic D; Cheever AW; Kullberg MC; Wynn TA; Yap G; Caspar P; Lewis FA; Clynes R; Ravetch JV; Sher A. 1998. CD4+ T cell-mediated granulomatous pathology in schistosomiasis is downregulated by a B cell-dependent mechanism requiring Fc receptor signaling. J Exp Med 187(4):619-29. [PubMed: 9463412]  [MGI Ref ID J:119259]

Jeannet G; Coudert JD; Held W. 2006. T and B lymphocytes exert distinct effects on the homeostasis of NK cells. Eur J Immunol 36(10):2725-34. [PubMed: 16955521]  [MGI Ref ID J:118107]

Johnson CM; Cooper AM; Frank AA; Bonorino CB; Wysoki LJ; Orme IM. 1997. Mycobacterium tuberculosis aerogenic rechallenge infections in B cell-deficient mice. Tuber Lung Dis 78(5-6):257-61. [PubMed: 10209680]  [MGI Ref ID J:55984]

Justice JP; Crosby J; Borchers MT; Tomkinson A; Lee JJ; Lee NA. 2002. CD4(+) T cell-dependent airway mucus production occurs in response to IL-5 expression in lung. Am J Physiol Lung Cell Mol Physiol 282(5):L1066-74. [PubMed: 11943672]  [MGI Ref ID J:108354]

Kabashima K; Banks TA; Ansel KM; Lu TT; Ware CF; Cyster JG. 2005. Intrinsic lymphotoxin-beta receptor requirement for homeostasis of lymphoid tissue dendritic cells. Immunity 22(4):439-50. [PubMed: 15845449]  [MGI Ref ID J:97986]

Kang H; Remington JS; Suzuki Y. 2000. Decreased resistance of B cell-deficient mice to infection with Toxoplasma gondii despite unimpaired expression of IFN-gamma, TNF-alpha, and inducible nitric oxide synthase. J Immunol 164(5):2629-34. [PubMed: 10679102]  [MGI Ref ID J:127000]

Kang HK; Chung YJ; Park CU; Jang YS; Kim BS. 2006. Induction of autoimmunity by immunization with hapten-modified hen egg lysozyme in hen egg lysozyme-transgenic mice. Immunology 117(3):368-78. [PubMed: 16476056]  [MGI Ref ID J:107066]

Kassiotis G; Bauer J; Akassoglou K; Lassmann H; Kollias G; Probert L. 1999. A tumor necrosis factor-induced model of human primary demyelinating diseases develops in immunodeficient mice. Eur J Immunol 29(3):912-7. [PubMed: 10092095]  [MGI Ref ID J:53471]

Kawabata H; Niwa A; Tsuji-Kawahara S; Uenishi H; Iwanami N; Matsukuma H; Abe H; Tabata N; Matsumura H; Miyazawa M. 2006. Peptide-induced immune protection of CD8+ T cell-deficient mice against Friend retrovirus-induced disease. Int Immunol 18(1):183-98. [PubMed: 16352628]  [MGI Ref ID J:104156]

Kawikova I; Paliwal V; Szczepanik M; Itakura A; Fukui M; Campos RA; Geba GP; Homer RJ; Iliopoulou BP; Pober JS; Tsuji RF; Askenase PW. 2004. Airway hyper-reactivity mediated by B-1 cell immunoglobulin M antibody generating complement C5a at 1 day post-immunization in a murine hapten model of non-atopic asthma. Immunology 113(2):234-45. [PubMed: 15379984]  [MGI Ref ID J:92933]

Kersseboom R; Ta VB; Zijlstra AJ; Middendorp S; Jumaa H; van Loo PF; Hendriks RW. 2006. Bruton's tyrosine kinase and SLP-65 regulate pre-B cell differentiation and the induction of Ig light chain gene rearrangement. J Immunol 176(8):4543-52. [PubMed: 16585544]  [MGI Ref ID J:131167]

Kikuchi T; Andarini S; Xin H; Gomi K; Tokue Y; Saijo Y; Honjo T; Watanabe A; Nukiwa T. 2005. Involvement of fractalkine/CX3CL1 expression by dendritic cells in the enhancement of host immunity against Legionella pneumophila. Infect Immun 73(9):5350-7. [PubMed: 16113250]  [MGI Ref ID J:100418]

Kitamura D; Rajewsky K. 1992. Targeted disruption of mu chain membrane exon causes loss of heavy-chain allelic exclusion [see comments] Nature 356(6365):154-6. [PubMed: 1545868]  [MGI Ref ID J:64298]

Kitamura D; Roes J; Kuhn R; Rajewsky K. 1991. A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene. Nature 350(6317):423-6. [PubMed: 1901381]  [MGI Ref ID J:70398]

Klein MA; Frigg R; Flechsig E; Raeber AJ; Kalinke U; Bluethmann H; Bootz F; Suter M; Zinkernagel RM; Aguzzi A. 1997. A crucial role for B cells in neuroinvasive scrapie [see comments] Nature 390(6661):687-90. [PubMed: 9414161]  [MGI Ref ID J:44933]

Klein MA; Kaeser PS; Schwarz P; Weyd H; Xenarios I; Zinkernagel RM; Carroll MC; Verbeek JS; Botto M; Walport MJ; Molina H; Kalinke U; Acha-Orbea H; Aguzzi A. 2001. Complement facilitates early prion pathogenesis. Nat Med 7(4):488-92. [PubMed: 11283678]  [MGI Ref ID J:125467]

Kontoyiannis D; Boulougouris G; Manoloukos M; Armaka M; Apostolaki M; Pizarro T; Kotlyarov A; Forster I; Flavell R; Gaestel M; Tsichlis P; Cominelli F; Kollias G. 2002. Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease. J Exp Med 196(12):1563-74. [PubMed: 12486099]  [MGI Ref ID J:108572]

Korsgren M; Erjefalt JS; Korsgren O; Sundler F; Persson CG. 1997. Allergic eosinophil-rich inflammation develops in lungs and airways of B cell-deficient mice. J Exp Med 185(5):885-92. [PubMed: 9120394]  [MGI Ref ID J:38781]

Kouskoff V; Korganow AS; Duchatelle V; Degott C; Benoist C; Mathis D. 1996. Organ-specific disease provoked by systemic autoimmunity. Cell 87(5):811-22. [PubMed: 8945509]  [MGI Ref ID J:36815]

Kubo S; Nakayama T; Matsuoka K; Yonekawa H; Karasuyama H. 2003. Long term maintenance of IgE-mediated memory in mast cells in the absence of detectable serum IgE. J Immunol 170(2):775-80. [PubMed: 12517940]  [MGI Ref ID J:127137]

KuoLee R; Zhao X; Austin J; Harris G; Conlan JW; Chen W. 2007. Mouse model of oral infection with virulent type A Francisella tularensis. Infect Immun 75(4):1651-60. [PubMed: 17242058]  [MGI Ref ID J:119508]

Langford TD; Housley MP; Boes M; Chen J; Kagnoff MF; Gillin FD; Eckmann L. 2002. Central importance of immunoglobulin A in host defense against Giardia spp. Infect Immun 70(1):11-8. [PubMed: 11748158]  [MGI Ref ID J:74568]

Langhorne J; Cross C; Seixas E; Li C; von der Weid T. 1998. A role for B cells in the development of T cell helper function in a malaria infection in mice. Proc Natl Acad Sci U S A 95(4):1730-4. [PubMed: 9465085]  [MGI Ref ID J:120241]

Laouar A; Haridas V; Vargas D; Zhinan X; Chaplin D; van Lier RA; Manjunath N. 2005. CD70+ antigen-presenting cells control the proliferation and differentiation of T cells in the intestinal mucosa. Nat Immunol 6(7):698-706. [PubMed: 15937486]  [MGI Ref ID J:99148]

Le Bon A; Thompson C; Kamphuis E; Durand V; Rossmann C; Kalinke U; Tough DF. 2006. Cutting edge: enhancement of antibody responses through direct stimulation of B and T cells by type I IFN. J Immunol 176(4):2074-8. [PubMed: 16455962]  [MGI Ref ID J:129128]

Lee BO; Rangel-Moreno J; Moyron-Quiroz JE; Hartson L; Makris M; Sprague F; Lund FE; Randall TD. 2005. CD4 T cell-independent antibody response promotes resolution of primary influenza infection and helps to prevent reinfection. J Immunol 175(9):5827-38. [PubMed: 16237075]  [MGI Ref ID J:119355]

Leiter EH. 1998. NOD Mice and Related Strains: Origins, Husbandry and Biology Introduction. In: NOD Mice and Related Strains: Research Applications in Diabetes, AIDS, Cancer, and Other Diseases. RG Landes, Austin.  [MGI Ref ID J:110093]

Lentz VM; Manser T. 2000. Self-limiting systemic autoimmune disease during reconstitution of T cell-deficient mice with syngeneic T cells: support for a multifaceted role of T cells in the maintenance of peripheral B cell tolerance. Int Immunol 12(11):1483-97. [PubMed: 11058568]  [MGI Ref ID J:110494]

Lewkowich IP; Rempel JD; HayGlass KT. 2005. Prevention of allergen-specific, Th2-biased immune responses in vivo: role of increased IL-12 and IL-18 responsiveness. J Immunol 175(8):4956-62. [PubMed: 16210597]  [MGI Ref ID J:119100]

Li H; Shi FD; He B; Bakheit M; Wahren B; Berglof A; Sandstedt K; Link H. 1998. Experimental autoimmune myasthenia gravis induction in B cell-deficient mice. Int Immunol 10(9):1359-65. [PubMed: 9786435]  [MGI Ref ID J:110499]

Liao S; Ruddle NH. 2006. Synchrony of high endothelial venules and lymphatic vessels revealed by immunization. J Immunol 177(5):3369-79. [PubMed: 16920978]  [MGI Ref ID J:139499]

Lin MT; Hinton DR; Marten NW; Bergmann CC; Stohlman SA. 1999. Antibody prevents virus reactivation within the central nervous system. J Immunol 162(12):7358-68. [PubMed: 10358187]  [MGI Ref ID J:120237]

Ling YM; Shaw MH; Ayala C; Coppens I; Taylor GA; Ferguson DJ; Yap GS. 2006. Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages. J Exp Med 203(9):2063-71. [PubMed: 16940170]  [MGI Ref ID J:124556]

Linton PJ; Harbertson J; Bradley LM. 2000. A critical role for B cells in the development of memory CD4 cells. J Immunol 165(10):5558-65. [PubMed: 11067910]  [MGI Ref ID J:118565]

Liu R; Van Kaer L; La Cava A; Price M; Campagnolo DI; Collins M; Young DA; Vollmer TL; Shi FD. 2006. Autoreactive T cells mediate NK cell degeneration in autoimmune disease. J Immunol 176(9):5247-54. [PubMed: 16621990]  [MGI Ref ID J:131629]

Liu X; Manser T. 2005. Antinuclear antigen B cells that down-regulate surface B cell receptor during development to mature, follicular phenotype do not display features of anergy in vitro. J Immunol 174(8):4505-15. [PubMed: 15814671]  [MGI Ref ID J:98165]

Livingstone AM; Kuhn M. 2002. Peptide-pulsed splenic dendritic cells prime long-lasting CD8(+) T cell memory in the absence of cross-priming by host APC. Eur J Immunol 32(1):281-90. [PubMed: 11782019]  [MGI Ref ID J:73930]

Logunova NN; Viret C; Pobezinsky LA; Miller SA; Kazansky DB; Sundberg JP; Chervonsky AV. 2005. Restricted MHC-peptide repertoire predisposes to autoimmunity. J Exp Med 202(1):73-84. [PubMed: 15998789]  [MGI Ref ID J:100625]

Londono D; Bai Y; Zuckert WR; Gelderblom H; Cadavid D. 2005. Cardiac apoptosis in severe relapsing fever borreliosis. Infect Immun 73(11):7669-76. [PubMed: 16239571]  [MGI Ref ID J:104291]

Louten J; van Rooijen N; Biron CA. 2006. Type 1 IFN deficiency in the absence of normal splenic architecture during lymphocytic choriomeningitis virus infection. J Immunol 177(5):3266-72. [PubMed: 16920967]  [MGI Ref ID J:139540]

Lund FE; Hollifield M; Schuer K; Lines JL; Randall TD; Garvy BA. 2006. B cells are required for generation of protective effector and memory CD4 cells in response to Pneumocystis lung infection. J Immunol 176(10):6147-54. [PubMed: 16670323]  [MGI Ref ID J:131763]

Lund FE; Schuer K; Hollifield M; Randall TD; Garvy BA. 2003. Clearance of Pneumocystis carinii in mice is dependent on B cells but not on P carinii-specific antibody. J Immunol 171(3):1423-30. [PubMed: 12874234]  [MGI Ref ID J:120666]

Luther SA; Lopez T; Bai W; Hanahan D; Cyster JG. 2000. BLC expression in pancreatic islets causes B cell recruitment and lymphotoxin-dependent lymphoid neogenesis. Immunity 12(5):471-81. [PubMed: 10843380]  [MGI Ref ID J:110548]

Lyons BL; Lynes MA; Burzenski L; Joliat MJ; Hadjout N; Shultz LD. 2003. Mechanisms of anemia in SHP-1 protein tyrosine phosphatase-deficient 'viable motheaten' mice. Exp Hematol 31(3):234-43. [PubMed: 12644021]  [MGI Ref ID J:82283]

Maaser C; Housley MP; Iimura M; Smith JR; Vallance BA; Finlay BB; Schreiber JR; Varki NM; Kagnoff MF; Eckmann L. 2004. Clearance of Citrobacter rodentium requires B cells but not secretory immunoglobulin A (IgA) or IgM antibodies. Infect Immun 72(6):3315-24. [PubMed: 15155635]  [MGI Ref ID J:90245]

MacLean JA; Sauty A; Luster AD; Drazen JM; De Sanctis GT. 1999. Antigen-induced airway hyperresponsiveness, pulmonary eosinophilia, and chemokine expression in B cell-deficient mice. Am J Respir Cell Mol Biol 20(3):379-87. [PubMed: 10030835]  [MGI Ref ID J:114252]

Macpherson AJ; Lamarre A; McCoy K; Harriman GR; Odermatt B; Dougan G; Hengartner H; Zinkernagel RM. 2001. IgA production without mu or delta chain expression in developing B cells. Nat Immunol 2(7):625-31. [PubMed: 11429547]  [MGI Ref ID J:70173]

Magee DM; Friedberg RL; Woitaske MD; Johnston SA; Cox RA. 2005. Role of B cells in vaccine-induced immunity against coccidioidomycosis. Infect Immun 73(10):7011-3. [PubMed: 16177382]  [MGI Ref ID J:104209]

Mahon BP; Sheahan BJ; Griffin F; Murphy G; Mills KH. 1997. Atypical disease after Bordetella pertussis respiratory infection of mice with targeted disruptions of interferon-gamma receptor or immunoglobulin mu chain genes. J Exp Med 186(11):1843-51. [PubMed: 9382883]  [MGI Ref ID J:44402]

Major AS; Fazio S; Linton MF. 2002. B-lymphocyte deficiency increases atherosclerosis in LDL receptor-null mice. Arterioscler Thromb Vasc Biol 22(11):1892-8. [PubMed: 12426221]  [MGI Ref ID J:103218]

Malkiel S; Factor S; Diamond B. 1999. Autoimmune myocarditis does not require B cells for antigen presentation. J Immunol 163(10):5265-8. [PubMed: 10553048]  [MGI Ref ID J:118448]

Malley R; Srivastava A; Lipsitch M; Thompson CM; Watkins C; Tzianabos A; Anderson PW. 2006. Antibody-independent, interleukin-17A-mediated, cross-serotype immunity to pneumococci in mice immunized intranasally with the cell wall polysaccharide. Infect Immun 74(4):2187-95. [PubMed: 16552049]  [MGI Ref ID J:107408]

Malley R; Trzcinski K; Srivastava A; Thompson CM; Anderson PW; Lipsitch M. 2005. CD4+ T cells mediate antibody-independent acquired immunity to pneumococcal colonization. Proc Natl Acad Sci U S A 102(13):4848-53. [PubMed: 15781870]  [MGI Ref ID J:97363]

Mao D; Wu X; Deppong C; Friend LD; Dolecki G; Nelson DM; Molina H. 2003. Negligible role of antibodies and C5 in pregnancy loss associated exclusively with C3-dependent mechanisms through complement alternative pathway. Immunity 19(6):813-22. [PubMed: 14670299]  [MGI Ref ID J:86999]

Marquina R; Diez MA; Lopez-Hoyos M; Buelta L; Kuroki A; Kikuchi S; Villegas J; Pihlgren M; Siegrist CA; Arias M; Izui S; Merino J; Merino R. 2004. Inhibition of B cell death causes the development of an IgA nephropathy in (New Zealand white x C57BL/6)F(1)-bcl-2 transgenic mice. J Immunol 172(11):7177-85. [PubMed: 15153542]  [MGI Ref ID J:90535]

Marshall AJ; Fleming HE; Wu GE; Paige CJ. 1998. Modulation of the IL-7 dose-response threshold during pro-B cell differentiation is dependent on pre-B cell receptor expression. J Immunol 161(11):6038-45. [PubMed: 9834086]  [MGI Ref ID J:115032]

Marusic A; Grcevic D; Katavic V; Kovacic N; Lukic IK; Kalajzic I; Lorenzo JA. 2000. Role of B lymphocytes in new bone formation Lab Invest 80(11):1761-74. [PubMed: 11092536]  [MGI Ref ID J:65914]

Matlack R; Yeh K; Rosini L; Gonzalez D; Taylor J; Silberman D; Pennello A; Riggs J. 2006. Peritoneal macrophages suppress T-cell activation by amino acid catabolism. Immunology 117(3):386-95. [PubMed: 16476058]  [MGI Ref ID J:107076]

Matsumura Y; Byrne SN; Nghiem DX; Miyahara Y; Ullrich SE. 2006. A role for inflammatory mediators in the induction of immunoregulatory B cells. J Immunol 177(7):4810-7. [PubMed: 16982922]  [MGI Ref ID J:139306]

McCool TL; Weiser JN. 2004. Limited role of antibody in clearance of Streptococcus pneumoniae in a murine model of colonization. Infect Immun 72(10):5807-13. [PubMed: 15385481]  [MGI Ref ID J:93131]

Melamed D; Miri E; Leider N; Nemazee D. 2000. Unexpected autoantibody production in membrane Ig-mu-deficient/lpr mice. J Immunol 165(8):4353-8. [PubMed: 11035071]  [MGI Ref ID J:119584]

Mena I; Perry CM; Harkins S; Rodriguez F; Gebhard J; Whitton JL. 1999. The role of B lymphocytes in coxsackievirus B3 infection. Am J Pathol 155(4):1205-15. [PubMed: 10514403]  [MGI Ref ID J:108258]

Merkler D; Horvath E; Bruck W; Zinkernagel RM; Del la Torre JC; Pinschewer DD. 2006. 'Viral deja vu' elicits organ-specific immune disease independent of reactivity to self. J Clin Invest 116(5):1254-63. [PubMed: 16604192]  [MGI Ref ID J:108857]

Meyer-Bahlburg A; Andrews SF; Yu KO; Porcelli SA; Rawlings DJ. 2008. Characterization of a late transitional B cell population highly sensitive to BAFF-mediated homeostatic proliferation. J Exp Med 205(1):155-68. [PubMed: 18180309]  [MGI Ref ID J:131142]

Meyer-Bahlburg A; Khim S; Rawlings DJ. 2007. B cell intrinsic TLR signals amplify but are not required for humoral immunity. J Exp Med 204(13):3095-101. [PubMed: 18039950]  [MGI Ref ID J:130405]

Miller JP; Izon D; DeMuth W; Gerstein R; Bhandoola A; Allman D. 2002. The earliest step in B lineage differentiation from common lymphoid progenitors is critically dependent upon interleukin 7. J Exp Med 196(5):705-11. [PubMed: 12208884]  [MGI Ref ID J:119428]

Mills DM; Bonizzi G; Karin M; Rickert RC. 2007. Regulation of late B cell differentiation by intrinsic IKK{alpha}-dependent signals. Proc Natl Acad Sci U S A 104(15):6359-64. [PubMed: 17404218]  [MGI Ref ID J:120850]

Mishra A; Schlotman J; Wang M; Rothenberg ME. 2007. Critical role for adaptive T cell immunity in experimental eosinophilic esophagitis in mice. J Leukoc Biol 81(4):916-24. [PubMed: 17194734]  [MGI Ref ID J:121455]

Mittrucker HW; Raupach B; Kohler A; Kaufmann SH. 2000. Cutting edge: role of B lymphocytes in protective immunity against Salmonella typhimurium infection. J Immunol 164(4):1648-52. [PubMed: 10657605]  [MGI Ref ID J:60395]

Mizoguchi A; Mizoguchi E; Smith RN; Preffer FI; Bhan AK. 1997. Suppressive role of B cells in chronic colitis of T cell receptor alpha mutant mice. J Exp Med 186(10):1749-56. [PubMed: 9362534]  [MGI Ref ID J:111516]

Mizoguchi A; Ogawa A; Takedatsu H; Sugimoto K; Shimomura Y; Shirane K; Nagahama K; Nagaishi T; Mizoguchi E; Blumberg RS; Bhan AK. 2007. Dependence of intestinal granuloma formation on unique myeloid DC-like cells. J Clin Invest 117(3):605-15. [PubMed: 17318261]  [MGI Ref ID J:120740]

Mizoguchi E; Mizoguchi A; Preffer FI; Bhan AK. 2000. Regulatory role of mature B cells in a murine model of inflammatory bowel disease. Int Immunol 12(5):597-605. [PubMed: 10784605]  [MGI Ref ID J:110524]

Morrison SG; Morrison RP. 2005. A predominant role for antibody in acquired immunity to chlamydial genital tract reinfection. J Immunol 175(11):7536-42. [PubMed: 16301662]  [MGI Ref ID J:122166]

Morrison TE; Whitmore AC; Shabman RS; Lidbury BA; Mahalingam S; Heise MT. 2006. Characterization of Ross River virus tropism and virus-induced inflammation in a mouse model of viral arthritis and myositis. J Virol 80(2):737-49. [PubMed: 16378976]  [MGI Ref ID J:105656]

Mozdzanowska K; Maiese K; Gerhard W. 2000. Th cell-deficient mice control influenza virus infection more effectively than Th- and B cell-deficient mice: evidence for a Th-independent contribution by B cells to virus clearance. J Immunol 164(5):2635-43. [PubMed: 10679103]  [MGI Ref ID J:126999]

Mrusek S; Vallbracht S; Ehl S. 2005. The impact of splenectomy on antiviral T cell memory in mice. Int Immunol 17(1):27-33. [PubMed: 15520043]  [MGI Ref ID J:94798]

Murthy AK; Sharma J; Coalson JJ; Zhong G; Arulanandam BP. 2004. Chlamydia trachomatis pulmonary infection induces greater inflammatory pathology in immunoglobulin A deficient mice. Cell Immunol 230(1):56-64. [PubMed: 15541719]  [MGI Ref ID J:93852]

Nanni P; Landuzzi L; Nicoletti G; De Giovanni C; Rossi I; Croci S; Astolfi A; Iezzi M; Di Carlo E; Musiani P; Forni G; Lollini PL. 2004. Immunoprevention of Mammary Carcinoma in HER-2/neu Transgenic Mice Is IFN-{gamma} and B Cell Dependent. J Immunol 173(4):2288-2296. [PubMed: 15294941]  [MGI Ref ID J:92111]

Ngo VN; Cornall RJ; Cyster JG. 2001. Splenic T zone development is B cell dependent. J Exp Med 194(11):1649-60. [PubMed: 11733579]  [MGI Ref ID J:73100]

Nishiyama Y; Hamada H; Nonaka S; Yamamoto H; Nanno M; Katayama Y; Takahashi H; Ishikawa H. 2002. Homeostatic regulation of intestinal villous epithelia by B lymphocytes. J Immunol 168(6):2626-33. [PubMed: 11884426]  [MGI Ref ID J:126867]

Nolte MA; Arens R; Kraus M; van Oers MH; Kraal G; van Lier RA; Mebius RE. 2004. B cells are crucial for both development and maintenance of the splenic marginal zone. J Immunol 172(6):3620-7. [PubMed: 15004164]  [MGI Ref ID J:88620]

Noorchashm H; Lieu YK; Noorchashm N; Rostami SY; Greeley SA; Schlachterman A; Song HK; Noto LE; Jevnikar AM; Barker CF; Naji A. 1999. I-Ag7-mediated antigen presentation by B lymphocytes is critical in overcoming a checkpoint in T cell tolerance to islet beta cells of nonobese diabetic mice. J Immunol 163(2):743-50. [PubMed: 10395666]  [MGI Ref ID J:56160]

Noorchashm H; Reed AJ; Rostami SY; Mozaffari R; Zekavat G; Koeberlein B; Caton AJ; Naji A. 2006. B cell-mediated antigen presentation is required for the pathogenesis of acute cardiac allograft rejection. J Immunol 177(11):7715-22. [PubMed: 17114442]  [MGI Ref ID J:140848]

Nozaki T; Rosenblum JM; Ishii D; Tanabe K; Fairchild RL. 2008. CD4 T cell-mediated rejection of cardiac allografts in B cell-deficient mice. J Immunol 181(8):5257-63. [PubMed: 18832680]  [MGI Ref ID J:140775]

Okada T; Miller MJ; Parker I; Krummel MF; Neighbors M; Hartley SB; O'Garra A; Cahalan MD; Cyster JG. 2005. Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells. PLoS Biol 3(6):e150. [PubMed: 15857154]  [MGI Ref ID J:99611]

Orinska Z; Osiak A; Lohler J; Bulanova E; Budagian V; Horak I; Bulfone-Paus S. 2002. Novel B cell population producing functional IgG in the absence of membrane IgM expression. Eur J Immunol 32(12):3472-80. [PubMed: 12442329]  [MGI Ref ID J:80854]

Oya K; Wang J; Watanabe Y; Koga R; Watanabe T. 2003. Appearance of the LAT protein at an early stage of B-cell development and its possible role. Immunology 109(3):351-9. [PubMed: 12807480]  [MGI Ref ID J:84079]

Paciorkowski N; Porte P; Shultz LD; Rajan TV. 2000. B1 B lymphocytes play a critical role in host protection against lymphatic filarial parasites. J Exp Med 191(4):731-6. [PubMed: 10684864]  [MGI Ref ID J:112016]

Parent MA; Wilhelm LB; Kummer LW; Szaba FM; Mullarky IK; Smiley ST. 2006. Gamma interferon, tumor necrosis factor alpha, and nitric oxide synthase 2, key elements of cellular immunity, perform critical protective functions during humoral defense against lethal pulmonary Yersinia pestis infection. Infect Immun 74(6):3381-6. [PubMed: 16714568]  [MGI Ref ID J:109236]

Parr MB; Parr EL. 2000. Immunity to vaginal herpes simplex virus-2 infection in B-cell knockout mice. Immunology 101(1):126-31. [PubMed: 11012763]  [MGI Ref ID J:64870]

Pasare C; Medzhitov R. 2005. Control of B-cell responses by Toll-like receptors. Nature 438(7066):364-8. [PubMed: 16292312]  [MGI Ref ID J:102766]

Perona-Wright G; Jenkins SJ; Crawford A; Gray D; Pearce EJ; MacDonald AS. 2006. Distinct sources and targets of IL-10 during dendritic cell-driven Th1 and Th2 responses in vivo. Eur J Immunol 36(9):2367-75. [PubMed: 16917957]  [MGI Ref ID J:116745]

Perona-Wright G; Mohrs K; Taylor J; Zaph C; Artis D; Pearce EJ; Mohrs M. 2008. Cutting edge: Helminth infection induces IgE in the absence of mu- or delta-chain expression. J Immunol 181(10):6697-701. [PubMed: 18981085]  [MGI Ref ID J:140953]

Phillips JA; Romball CG; Hobbs MV; Ernst DN; Shultz L; Weigle WO. 1996. CD4+ T cell activation and tolerance induction in B cell knockout mice. J Exp Med 183(4):1339-44. [PubMed: 8666892]  [MGI Ref ID J:110756]

Pilione MR; Harvill ET. 2006. The Bordetella bronchiseptica type III secretion system inhibits gamma interferon production that is required for efficient antibody-mediated bacterial clearance. Infect Immun 74(2):1043-9. [PubMed: 16428751]  [MGI Ref ID J:105004]

Polic B; Hengel H; Krmpotic A; Trgovcich J; Pavic I; Luccaronin P; Jonjic S; Koszinowski UH. 1998. Hierarchical and redundant lymphocyte subset control precludes cytomegalovirus replication during latent infection. J Exp Med 188(6):1047-54. [PubMed: 9743523]  [MGI Ref ID J:115208]

Price GE; Huang L; Ou R; Zhang M; Moskophidis D. 2005. Perforin and Fas cytolytic pathways coordinately shape the selection and diversity of CD8+-T-cell escape variants of influenza virus. J Virol 79(13):8545-59. [PubMed: 15956596]  [MGI Ref ID J:99433]

Prinz M; Huber G; Macpherson AJ; Heppner FL; Glatzel M; Eugster HP; Wagner N; Aguzzi A. 2003. Oral Prion Infection Requires Normal Numbers of Peyer's Patches but Not of Enteric Lymphocytes. Am J Pathol 162(4):1103-11. [PubMed: 12651603]  [MGI Ref ID J:82476]

Qin Z; Richter G; Schuler T; Ibe S; Cao X; Blankenstein T. 1998. B cells inhibit induction of T cell-dependent tumor immunity. Nat Med 4(5):627-30. [PubMed: 9585241]  [MGI Ref ID J:48909]

Quemeneur L; Angeli V; Chopin M; Jessberger R. 2008. SWAP-70 deficiency causes high-affinity plasma cell generation despite impaired germinal center formation. Blood 111(5):2714-24. [PubMed: 18094331]  [MGI Ref ID J:131581]

Rangel-Moreno J; Carragher DM; Misra RS; Kusser K; Hartson L; Moquin A; Lund FE; Randall TD. 2008. B cells promote resistance to heterosubtypic strains of influenza via multiple mechanisms. J Immunol 180(1):454-63. [PubMed: 18097047]  [MGI Ref ID J:130893]

Ren L; Zou X; Smith JA; Bruggemann M. 2004. Silencing of the immunoglobulin heavy chain locus by removal of all eight constant-region genes in a 200-kb region. Genomics 84(4):686-95. [PubMed: 15475246]  [MGI Ref ID J:118453]

Rivera A; Chen CC; Ron N; Dougherty JP; Ron Y. 2001. Role of B cells as antigen-presenting cells in vivo revisited: antigen-specific B cells are essential for T cell expansion in lymph nodes and for systemic T cell responses to low antigen concentrations. Int Immunol 13(12):1583-93. [PubMed: 11717199]  [MGI Ref ID J:107395]

Rivera J; Zaragoza O; Casadevall A. 2005. Antibody-mediated protection against Cryptococcus neoformans pulmonary infection is dependent on B cells. Infect Immun 73(2):1141-50. [PubMed: 15664957]  [MGI Ref ID J:95620]

Rolan HG; Tsolis RM. 2007. Mice lacking components of adaptive immunity show increased Brucella abortus virB mutant colonization. Infect Immun 75(6):2965-73. [PubMed: 17420243]  [MGI Ref ID J:121919]

Rolink A; Grawunder U; Winkler TH; Karasuyama H; Melchers F. 1994. IL-2 receptor alpha chain (CD25, TAC) expression defines a crucial stage in pre-B cell development. Int Immunol 6(8):1257-64. [PubMed: 7526894]  [MGI Ref ID J:22573]

Roth KA; Kapadia SB; Martin SM; Lorenz RG. 1999. Cellular immune responses are essential for the development of Helicobacter felis-associated gastric pathology. J Immunol 163(3):1490-7. [PubMed: 10415051]  [MGI Ref ID J:56994]

Roth PE; Kurtz B; Lo D; Storb U. 1995. lambda 5, but not mu, is required for B cell maturation in a unique gamma 2b transgenic mouse line. J Exp Med 181(3):1059-70. [PubMed: 7869028]  [MGI Ref ID J:23341]

Rottman M; Catherinot E; Hochedez P; Emile JF; Casanova JL; Gaillard JL; Soudais C. 2007. Importance of T cells, gamma interferon, and tumor necrosis factor in immune control of the rapid grower Mycobacterium abscessus in C57BL/6 mice. Infect Immun 75(12):5898-907. [PubMed: 17875636]  [MGI Ref ID J:127652]

Russell PS; Chase CM; Colvin RB. 1997. Alloantibody- and T cell-mediated immunity in the pathogenesis of transplant arteriosclerosis: lack of progression to sclerotic lesions in B cell-deficient mice. Transplantation 64(11):1531-6. [PubMed: 9415552]  [MGI Ref ID J:44888]

Sapoznikov A; Fischer JA; Zaft T; Krauthgamer R; Dzionek A; Jung S. 2007. Organ-dependent in vivo priming of naive CD4+, but not CD8+, T cells by plasmacytoid dendritic cells. J Exp Med 204(8):1923-33. [PubMed: 17646404]  [MGI Ref ID J:125954]

Savitsky D; Calame K. 2006. B-1 B lymphocytes require Blimp-1 for immunoglobulin secretion. J Exp Med 203(10):2305-14. [PubMed: 16954370]  [MGI Ref ID J:124626]

Sawa S; Kamimura D; Jin GH; Morikawa H; Kamon H; Nishihara M; Ishihara K; Murakami M; Hirano T. 2006. Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T cells. J Exp Med 203(6):1459-70. [PubMed: 16717113]  [MGI Ref ID J:124381]

Seagal J; Edry E; Naftali H; Melamed D. 2004. Generation and selection of an IgG-driven autoimmune repertoire during B-lymphopoiesis in Igmicro-deficient/lpr mice. Int Immunol 16(7):905-13. [PubMed: 15148286]  [MGI Ref ID J:90752]

Seagal J; Melamed D. 2004. Contribution of alphabeta and gammadelta T cells to the generation of primary immunoglobulin G-driven autoimmune response in immunoglobulin- mu-deficient/lpr mice. Immunology 112(2):265-73. [PubMed: 15147570]  [MGI Ref ID J:90503]

Seixas E; Fonseca L; Langhorne J. 2002. The influence of gammadelta T cells on the CD4+ T cell and antibody response during a primary Plasmodium chabaudi chabaudi infection in mice. Parasite Immunol 24(3):131-40. [PubMed: 11982858]  [MGI Ref ID J:134387]

Seixas EM; Langhorne J. 1999. gammadelta T cells contribute to control of chronic parasitemia in Plasmodium chabaudi infections in mice. J Immunol 162(5):2837-41. [PubMed: 10072531]  [MGI Ref ID J:124535]

Senn BM; Lopez-Macias C; Kalinke U; Lamarre A; Isibasi A; Zinkernagel RM; Hengartner H. 2003. Combinatorial immunoglobulin light chain variability creates sufficient B cell diversity to mount protective antibody responses against pathogen infections. Eur J Immunol 33(4):950-61. [PubMed: 12672061]  [MGI Ref ID J:82866]

Serpe CJ; Coers S; Sanders VM; Jones KJ. 2003. CD4+ T, but not CD8+ or B, lymphocytes mediate facial motoneuron survival after facial nerve transection. Brain Behav Immun 17(5):393-402. [PubMed: 12946661]  [MGI Ref ID J:105952]

Serreze DV; Chapman HD; Varnum DS; Hanson MS; Reifsnyder PC; Richard SD; Fleming SA; Leiter EH; Shultz LD. 1996. B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new speed congenic stock of NOD.Ig mu null mice. J Exp Med 184(5):2049-53. [PubMed: 8920894]  [MGI Ref ID J:37287]

Shen H; Whitmire JK; Fan X; Shedlock DJ; Kaech SM; Ahmed R. 2003. A specific role for B cells in the generation of CD8 T cell memory by recombinant Listeria monocytogenes. J Immunol 170(3):1443-51. [PubMed: 12538706]  [MGI Ref ID J:126273]

Shimomura Y; Mizoguchi E; Sugimoto K; Kibe R; Benno Y; Mizoguchi A; Bhan AK. 2008. Regulatory role of B-1 B cells in chronic colitis. Int Immunol 20(6):729-37. [PubMed: 18375938]  [MGI Ref ID J:136178]

Silveira PA; Chapman HD; Stolp J; Johnson E; Cox SL; Hunter K; Wicker LS; Serreze DV. 2006. Genes within the Idd5 and Idd9/11 Diabetes Susceptibility Loci Affect the Pathogenic Activity of B Cells in Nonobese Diabetic Mice. J Immunol 177(10):7033-41. [PubMed: 17082619]  [MGI Ref ID J:114754]

Silveira PA; Johnson E; Chapman HD; Bui T; Tisch RM; Serreze DV. 2002. The preferential ability of B lymphocytes to act as diabetogenic APC in NOD mice depends on expression of self-antigen-specific immunoglobulin receptors. Eur J Immunol 32(12):3657-66. [PubMed: 12516557]  [MGI Ref ID J:80859]

Skelsey ME; Mayhew E; Niederkorn JY. 2003. Splenic B cells act as antigen presenting cells for the induction of anterior chamber-associated immune deviation. Invest Ophthalmol Vis Sci 44(12):5242-51. [PubMed: 14638723]  [MGI Ref ID J:107362]

Smith-Norowitz TA; Sobel RA; Mokhtarian F. 2000. B cells and antibodies in the pathogenesis of myelin injury in Semliki Forest Virus encephalomyelitis. Cell Immunol 200(1):27-35. [PubMed: 10716880]  [MGI Ref ID J:114278]

Sobel ES; Satoh M; Chen Y; Wakeland EK; Morel L. 2002. The major murine systemic lupus erythematosus susceptibility locus Sle1 results in abnormal functions of both B and T cells. J Immunol 169(5):2694-700. [PubMed: 12193743]  [MGI Ref ID J:78570]

Souabni A; Jochum W; Busslinger M. 2007. Oncogenic role of Pax5 in the T-lymphoid lineage upon ectopic expression from the immunoglobulin heavy-chain locus. Blood 109(1):281-9. [PubMed: 16968900]  [MGI Ref ID J:118111]

Strick-Marchand H; Masse GX; Weiss MC; Di Santo JP. 2008. Lymphocytes support oval cell-dependent liver regeneration. J Immunol 181(4):2764-71. [PubMed: 18684967]  [MGI Ref ID J:140175]

Su H; Feilzer K; Caldwell HD; Morrison RP. 1997. Chlamydia trachomatis genital tract infection of antibody-deficient gene knockout mice. Infect Immun 65(6):1993-9. [PubMed: 9169723]  [MGI Ref ID J:40576]

Sullivan BA; Kraj P; Weber DA; Ignatowicz L; Jensen PE. 2002. Positive selection of a Qa-1-restricted T cell receptor with specificity for insulin. Immunity 17(1):95-105. [PubMed: 12150895]  [MGI Ref ID J:132383]

Sutherland AP; Ng LG; Fletcher CA; Shum B; Newton RA; Grey ST; Rolph MS; Mackay F; Mackay CR. 2005. BAFF augments certain Th1-associated inflammatory responses. J Immunol 174(9):5537-44. [PubMed: 15843552]  [MGI Ref ID J:98405]

Sutton P; Wilson J; Kosaka T; Wolowczuk I; Lee A. 2000. Therapeutic immunization against Helicobacter pylori infection in the absence of antibodies. Immunol Cell Biol 78(1):28-30. [PubMed: 10651926]  [MGI Ref ID J:110477]

Svensson L; Jirholt J; Holmdahl R; Jansson L. 1998. B cell-deficient mice do not develop type II collagen-induced arthritis (CIA). Clin Exp Immunol 111(3):521-6. [PubMed: 9528892]  [MGI Ref ID J:46988]

Svensson L; Lilliehook B; Larsson R; Bucht A. 2003. gammadelta T cells contribute to the systemic immunoglobulin E response and local B-cell reactivity in allergic eosinophilic airway inflammation. Immunology 108(1):98-108. [PubMed: 12519308]  [MGI Ref ID J:113627]

Swain SD; Meissner NN; Harmsen AG. 2006. CD8 T cells modulate CD4 T-cell and eosinophil-mediated pulmonary pathology in pneumocystis pneumonia in B-cell-deficient mice. Am J Pathol 168(2):466-75. [PubMed: