Strain Name:

B6.Cg-Tg(BAT-lacZ)3Picc/J

Stock Number:

005317

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Availability:

Repository- Live

Use Restrictions Apply, see Terms of Use
These the BAT-GAL transgenic mice (also called β-catenin/TCF/LEF reporter transgenic mice) are a reporter strain that expresses beta-galactosidase in the presence of activated beta-catenin (mimics the pattern of Wnt signaling). These mice may be useful for identifying mutations that affect the Wnt-signalling pathway, and in the identification of Wnt-responsive cell populations in development and disease.

Description

Strain Information

Type Congenic; Mutant Strain; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
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Additional information on Congenic nomenclature.
Mating SystemHomozygote x Homozygote         (Female x Male)   25-JUL-09
Specieslaboratory mouse
GenerationN6+N1F9 (10-DEC-13)
Generation Definitions
 
Donating Investigator Stefano Piccolo,   UNIVERSITY OF PADUA

Description
Mice homozygous for the transgenic insert are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. These "BAT-GAL" transgenic mice are a reporter strain that express beta-galactosidase in the presence of activated beta-catenin. The transgene expresses the lacZ gene under the control of a regulatory sequence consisting of seven consensus LEF/TCF-binding motifs upstream of the Xenopus siamois gene minimal promoter. Transgenic mice display beta-galactosidase activity beginning at embryonic day 6.0 in the posterior side of the proximal epiblast. Beta-galactosidase expression is detectable in the posterior primitive streak and node at gastrulation, and progresses to the paraxial mesoderm and notochord. Beta-galactosidase activity in developing and adult nervous tissue mimics the pattern of Wnt signaling. When bred to other mutant strains, this reporter strain may be useful for identifying mutations that affect the Wnt-signalling pathway, and in the identification of Wnt-responsive cell populations in development and disease.

In 2012, the laboratory of Dr. Glen L Radice (Thomas Jefferson University, Philadelphia) reported that when breeding BAT-GAL transgenic mice with junction plakoglobin mutant mice (Jup; see Stock No. 017575), the BAT-GAL transgene did not segregate randomly with respect to the Jup locus. They concluded that the BAT-GAL transgene is located within several centimorgans (11/201, 5.47% recombination frequency) of the Jup gene (Chr11:100230272-100259077 bp; - strand [NCBI Build 37]). For similar Wnt-signalling beta-galactosidase reporter function with mutant alleles on chromosome 11, they suggest considering TOP-GAL transgenic mice (Stock No. 004623).

Development
A transgenic construct containing the lacZ gene under the control of a promoter consisting of seven consensus LEF-/TCF-binding motifs upstream of the 0.13 kb minimal promoter of the Xenopus siamois gene was injected into fertilized B6D2F2 mouse eggs. Founder animals were bred to CD-1 outbred mice. After this, transgenic mice were bred to C57BL/6J mice for at least five generations prior to sending to The Jackson Laboratory Repository in 2006. Upon arrival, transgenic mice were bred once to C57BL/6J inbred mice (Stock No. 000664), and then the colony has been maintained by breeding transgenic mice together.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

lacZ Expression Strains
002484   129-Alpltm1Sor/J
002292   129-Gt(ROSA)26Sor/J
012756   129-Sirt4tm1Fwa/J
006050   129-Sirt6tm1Fwa/J
003451   129-Smad3tm1Par/J
003310   129S-Gt(ROSA)26Sortm1Sor/J
003383   129S-Nogtm1Amc/J
004545   129S-Npytm1Rpa/J
005091   129S-Pnpla6tm1Blw/J
007199   129S-Sgpl1Gt(ROSA)78Sor/J
003082   129S1/SvImJ-Bcl2tm1Mpin/J
010633   B6(Cg)-Gt(ROSA)26Sortm1(CAG-taulacZ)Bene/J
005085   B6.129(Cg)-Cd44tm1Hbg/J
012239   B6.129(Cg)-Cd44tm1Hbg/SjJ
004178   B6.129(Cg)-Tg(CAG-Bgeo/GFP)21Lbe/J
004478   B6.129-Foxd1tm1Lai/J
006939   B6.129-Fut1tm1Sdo/J
008606   B6.129-Gt(ROSA)26Sortm1Joe/J
005768   B6.129-Htr5atm1Dgen/J
002938   B6.129-Kdrtm1Jrt/J
004158   B6.129-Maftm1Gsb/J
006497   B6.129-Skiltm2Spw/J
009348   B6.129P2(Cg)-Hprttm17(Ple48-lacZ)Ems/Mmjax
012572   B6.129P2(Cg)-Hprttm19(Ple88-lacZ)Ems/Mmjax
012574   B6.129P2(Cg)-Hprttm38(Ple17-lacZ)Ems/Mmjax
012575   B6.129P2(Cg)-Hprttm39(Ple24-lacZ)Ems/Mmjax
012576   B6.129P2(Cg)-Hprttm40(Ple34-lacZ)Ems/Mmjax
010805   B6.129P2(Cg)-Hprttm41(Ple160-lacZ)Ems/Mmjax
012331   B6.129P2(Cg)-Hprttm42(Ple131-lacZ)Ems/Mmjax
012577   B6.129P2(Cg)-Hprttm43(Ple140-lacZ)Ems/Mmjax
010709   B6.129P2(Cg)-Hprttm44(Ple49-lacZ)Ems/Mmjax
012333   B6.129P2(Cg)-Hprttm45(Ple67-lacZ)Ems/Mmjax
012733   B6.129P2(Cg)-Hprttm53(CAG-lacZ)Ems/Mmjax
012578   B6.129P2(Cg)-Hprttm56(Ple25-lacZ)Ems/Mmjax
012579   B6.129P2(Cg)-Hprttm58(Ple119-lacZ)Ems/Mmjax
012580   B6.129P2(Cg)-Hprttm59(Ple123-lacZ)Ems/Mmjax
012581   B6.129P2(Cg)-Hprttm62(Ple153-lacZ)Ems/Mmjax
012342   B6.129P2(Cg)-Hprttm63(Ple12-lacZ)Ems/Mmjax
012347   B6.129P2(Cg)-Hprttm64(Ple170-lacZ)Ems/Mmjax
012582   B6.129P2(Cg)-Hprttm67(Ple238-lacZ)Ems/Mmjax
012583   B6.129P2(Cg)-Hprttm68(Ple127-lacZ)Ems/Mmjax
012656   B6.129P2(Cg)-Hprttm70(Ple240-lacZ)Ems/Mmjax
012657   B6.129P2(Cg)-Hprttm71(Ple155-lacZ)Ems/Mmjax
012659   B6.129P2(Cg)-Hprttm73(Ple142-lacZ)Ems/Mmjax
012734   B6.129P2(Cg)-Hprttm74(Ple232-lacZ)Ems/Mmjax
005772   B6.129P2-Acvrl1tm1Dgen/J
005770   B6.129P2-Adamts4tm1Dgen/J
005771   B6.129P2-Adamts5tm1Dgen/J
005773   B6.129P2-Adcy3tm1Dgen/J
005774   B6.129P2-Adcy7tm1Dgen/J
005775   B6.129P2-Adipor2tm1Dgen/J
005776   B6.129P2-Avpr1atm1Dgen/J
009120   B6.129P2-Axin2tm1Wbm/J
005777   B6.129P2-Axltm1Dgen/J
005783   B6.129P2-Cacna1ctm1Dgen/J
005780   B6.129P2-Cacna2d3tm1Dgen/J
005781   B6.129P2-Cacng3tm1Dgen/J
005782   B6.129P2-Cacng4tm1Dgen/J
005784   B6.129P2-Capn5tm1Dgen/J
005785   B6.129P2-Capn7tm1Dgen/J
005792   B6.129P2-Ccr1l1tm1Dgen/J
005793   B6.129P2-Ccr6tm1Dgen/J
005794   B6.129P2-Ccr7tm1Dgen/J
005779   B6.129P2-Celsr2tm1Dgen/J
005797   B6.129P2-Chrna2tm1Dgen/J
005787   B6.129P2-Ctsctm1Dgen/J
005796   B6.129P2-Cxcr3tm1Dgen/J
005798   B6.129P2-Drd5tm1Dgen/J
005800   B6.129P2-Efemp2tm1Dgen/J
005801   B6.129P2-Esrratm1Dgen/J
005802   B6.129P2-Faim2tm1Dgen/J
005803   B6.129P2-Fzd1tm1Dgen/J
005804   B6.129P2-Fzd8tm1Dgen/J
005811   B6.129P2-Gabra3tm1Dgen/J
005812   B6.129P2-Gabra4tm1Dgen/J
005810   B6.129P2-Gabrptm1Dgen/J
005809   B6.129P2-Galr1tm1Dgen/J
016094   B6.129P2-Git2Gt(XG510)Byg/WeisJ
005816   B6.129P2-Glra3tm1Dgen/J
005805   B6.129P2-Gpr151tm1Dgen/J
005806   B6.129P2-Gpr37tm1Dgen/J
005807   B6.129P2-Gpr6tm1Dgen/J
005813   B6.129P2-Grik5tm1Dgen/J
005808   B6.129P2-Grk5tm1Dgen/J
005814   B6.129P2-Grm1tm1Dgen/J
005815   B6.129P2-Grm3tm1Dgen/J
005817   B6.129P2-Gsk3btm1Dgen/J
005818   B6.129P2-Hcrtr1tm1Dgen/J
005767   B6.129P2-Htr4tm1Dgen/J
005769   B6.129P2-Htr7tm1Dgen/J
005830   B6.129P2-Kcnq2tm1Dgen/J
005821   B6.129P2-Lats2tm1Dgen/J
005822   B6.129P2-Lmbr1tm1Dgen/J
005850   B6.129P2-Mapkapk2tm1Dgen/J
005824   B6.129P2-Mmp17tm1Dgen/J
005825   B6.129P2-Mtmr1tm1Dgen/J
005826   B6.129P2-Ntsr1tm1Dgen/J
007767   B6.129P2-Olfr17tm1Mom/MomJ
005829   B6.129P2-Pkd2l2tm1Dgen/J
005828   B6.129P2-Ppardtm1Dgen/J
005831   B6.129P2-Ppm1ftm1Dgen/J
005827   B6.129P2-Ptch2tm1Dgen/J
005832   B6.129P2-Ptprotm1Dgen/J
005799   B6.129P2-S1pr4tm1Dgen/J
005837   B6.129P2-Scn11atm1Dgen/J
005836   B6.129P2-Scn9atm1Dgen/J
005834   B6.129P2-Sema5atm1Dgen/J
005835   B6.129P2-Sema6ctm1Dgen/J
006432   B6.129P2-Slc18a1tm1Dgen/J
005839   B6.129P2-Slc22a12tm1Dgen/J
005838   B6.129P2-Slc22a6tm1Dgen/J
005840   B6.129P2-Slc40a1tm1Dgen/J
005841   B6.129P2-Slc6a9tm1Dgen/J
005842   B6.129P2-Slc7a8tm1Dgen/J
005843   B6.129P2-Slc9a6tm1Dgen/J
012723   B6.129P2-Sptbn2Gt(XK442)Byg/LlpJ
005844   B6.129P2-Sstr1tm1Dgen/J
005847   B6.129P2-Tgfbr1tm1Dgen/J
005845   B6.129P2-Thbs4tm1Dgen/J
005790   B6.129P2-Tpp1tm1Dgen/J
005848   B6.129P2-Trpm5tm1Dgen/J
005791   B6.129P2-Xcr1tm1Dgen/J
012374   B6.129S-Artm1Rax/ShahJ
012377   B6.129S-Cyp19a1tm1.1Shah/J
009089   B6.129S1(Cg)-Ndntm2Stw/J
009386   B6.129S1-Osr2tm1Jian/J
007768   B6.129S2-Omptm1Mom/MomJ
003474   B6.129S4-Gt(ROSA)26Sortm1Sor/J
005901   B6.129S4-Ppardtm2Rev/J
006142   B6.129S4-Ppargtm1Rev/J
003754   B6.129S4-Shroom3Gt(ROSA53)Sor/J
013189   B6.129S5-Mlst8tm1Lex/J
013190   B6.129S5-MtorGt(OST92090)Lex/J
013191   B6.129S5-Rptortm1Lex/J
005119   B6.129S6-Npas2tm1Slm/J
002741   B6.129S7-Alpltm1Sor/J
005970   B6.129S7-Atoh1tm2Hzo/J
006039   B6.129S7-Efnb2tm1And/J
002192   B6.129S7-Gt(ROSA)26Sor/J
005981   B6.129S7-Rai1tm1Jrl/J
005039   B6.129X1-Adra1atm1Pcs/J
006262   B6.129X1-Fut2tm1Sdo/J
014536   B6.Cg-Hprttm75(Ple143-lacZ)Ems/Mmjax
007745   B6.Cg-Mir155tm1.1Rsky/J
003139   B6.Cg-Tg(DBHn-lacZ)8Rpk/J
006229   B6.Cg-Tg(DRE-lacZ)2Gswz/J
006773   B6.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd/J
024377   B6.Cg-Tg(TCF/Lef1-lacZ)34Efu/KatmJ
002982   B6.Cg-Tg(xstpx-lacZ)32And/J
008615   B6;129-Frzbtm1Nat/J
012820   B6;129-Fzd1tm1.1Nat/J
012821   B6;129-Fzd2tm1.1Nat/J
012822   B6;129-Fzd3tm1Nat/J
012824   B6;129-Fzd6tm1Nat/J
012825   B6;129-Fzd7tm1.1Nat/J
008516   B6;129-Gt(ROSA)26Sortm1Joe/J
003504   B6;129-Gt(ROSA)26Sortm1Sho/J
010590   B6;129-Iis1tm1(CAG-Bgeo,-tdTomato/TEVP,-SV2B/GFP)Nat/J
016857   B6;129-Itga7tm1Burk/J
018296   B6;129-Kcptm1Gdr/J
008614   B6;129-Sfrp2tm1Nat/J
012757   B6;129-Sirt5tm1Fwa/J
005064   B6;129-Slc30a3tm1Rpa/J
009599   B6;129P2-Adam19Gt(Betageo)1Bbl/J
006431   B6;129P2-Adam21tm1Dgen/J
005788   B6;129P2-Cd97tm1Dgen/J
006595   B6;129P2-Olfr17tm1Mom/MomJ
005833   B6;129P2-Rgs4tm1Dgen/J
012850   B6;129P2-TardbpGt(RRB030)Byg/J
002073   B6;129S-Gt(ROSA)26Sor/J
006470   B6;129S-Hopxtm1Eno/J
004153   B6;129S-Map7Gt(ROSABetageo)1Sor/J
006958   B6;129S-Nkd1tm1Kwha/J
006960   B6;129S-Nkd2tm1Kwha/J
006594   B6;129S2-Omptm1Mom/MomJ
007204   B6;129S4-2610005L07RikGt(ROSA)73Sor/J
011052   B6;129S4-Ctbp2Gt(ROSA61)Sor/J
003309   B6;129S4-Gt(ROSA)26Sortm1Sor/J
004365   B6;129S6-Srebf1tm1Mbr/J
002317   B6;129S7-Alpltm1Sor/J
003266   B6;129S7-Epas1tm1Rus/J
006044   B6;129S7-Ephb4tm1And/J
008618   B6;A-Tg(OPN1LW-lacZ)1Nat/J
003471   B6;C3H-Tg(CNP-GEO)1Ldh/J
006465   B6;CBA-Tg(CAG-lacZ-WGA)330Bbm/J
006680   B6;CBA-Tg(Olfr16*,taulacZ)19Mom/MomJ
006671   B6;CBA-Tg(Olfr16*,taulacZ)5Mom/MomJ
006672   B6;CBA-Tg(Olfr16*,taulacZ)7Mom/MomJ
006673   B6;CBA-Tg(Olfr16,taulacZ)sn2Mom/MomJ
004141   B6;CBA-Tg(UAS-lacZ)65Rth/J
008344   B6;DBA-Tg(Fos-tTA,Fos-EGFP*)1Mmay Tg(tetO-lacZ,tTA*)1Mmay/J
002369   B6;SJL-Tg(c177-lacZ)226Bri/J
002372   B6;SJL-Tg(c177-lacZ)227Bri/J
002621   B6;SJL-Tg(tetop-lacZ)2Mam/J
003299   B6;SWJ-Tg(TIMP3-lacZ)7Jeb/J
002865   B6CBA-Tg(Wnt1-lacZ)206Amc/J
016095   C.129P2(B6)-Git2Gt(XG510)Byg/WeisJ
016093   C.129S4(B6)-Git1Gt(FHCRC-GT-S10-12C1)Sor/WeisJ
002955   C.129S7-Gt(ROSA)26Sor/J
010683   C57BL/6-Enamtm1.1Jcch/J
010684   C57BL/6-Klk4tm1.1Jpsi/J
009062   C57BL/6-Magel2tm1Stw/J
002754   C57BL/6-Tg(LacZpl)60Vij/J
013729   C57BL/6-Tg(tetO-EDN1,-lacZ)9Mhus/J
013728   C57BL/6-Tg(tetO-NOS2,-lacZ)240iMhus/J
002193   C57BL/6J-Tg(MTn-lacZ)204Bri/J
002981   DBA/2-Tg(xstpx-lacZ)36And/J
004127   FVB-Tg(Nes-rtTA)306Rvs/J
007225   FVB.129(B6)-Usp18tm1Dzh/J
006214   FVB.129P2-Smn1tm1Msd/J
009427   FVB.129S4(B6)-Gt(ROSA)26Sortm1Sor/J
012429   FVB.Cg-Gt(ROSA)26Sortm1(CAG-lacZ,-EGFP)Glh/J
008206   FVB.Cg-Smn1tm1Msd Tg(SMN2)566Ahmb/J
008209   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(ACTA1-SMN)69Ahmb/J
005025   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
005026   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN1*A2G)2023Ahmb/J
005024   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd/J
003487   FVB.Cg-Tg(XGFAP-lacZ)3Mes/J
003140   FVB/N-Tg(PAI1-lacZ)1Jjb/J
002856   FVB/N-Tg(TIE2-lacZ)182Sato/J
005941   FVB/N-Tg(tetO-Aurkb,lacZ)41Kra/J
003315   FVB/N-Tg(tetORo1-lacZ)3Conk/J
005878   NOD.129(Cg)-Cd44tm1Hbg/J
003899   STOCK Cd44tm1Hbg/J
008602   STOCK Cdontm2Rsk/J
007912   STOCK En1tm2Alj/J
007925   STOCK En2tm5.1Alj/J
008211   STOCK Gli1tm2Alj/J
007922   STOCK Gli2tm2.1Alj/J
013123   STOCK Gt(ROSA)26Sortm6(Gli1)Amc/J
006241   STOCK Hhiptm1Amc/J
010707   STOCK Hprttm37(lacZ)Ems/Mmjax
012335   STOCK Hprttm50(Ple55-lacZ)Ems/Mmjax
013764   STOCK Hprttm57(Ple26-lacZ)Ems/Mmjax
012353   STOCK Hprttm65(Ple53-lacZ)Ems/Mmjax
012354   STOCK Hprttm66(Ple5-lacZ)Ems/Mmjax
012584   STOCK Hprttm69(Ple134-lacZ)Ems/Mmjax
012923   STOCK IppkGt(XA232)Byg/J
006578   STOCK Myoz2tm1Eno/J
005707   STOCK Rag1tm1Mom Tg(TIE2-lacZ)182Sato/J
006882   STOCK Tg(CAG-Bgeo,-AML1/ETO,-ALPP)1Lbe/J
005438   STOCK Tg(CAG-Bgeo,-DsRed*MST)1Nagy/J
006850   STOCK Tg(CAG-Bgeo,-NOTCH1,-EGFP)1Lbe/J
006876   STOCK Tg(CAG-Bgeo,-TEL/AML1,-EGFP)A6Lbe/J
006613   STOCK Tg(CAG-Bgeo,-Tle1,-ALPP)1Lbe/J
003919   STOCK Tg(CAG-Bgeo/ALPP)1Lbe/J
003920   STOCK Tg(CAG-Bgeo/GFP)21Lbe/J
006674   STOCK Tg(Olfr16,taulacZ)2030Mom/MomJ
008477   STOCK Tg(RARE-Hspa1b/lacZ)12Jrt/J
008203   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(ACTA1-SMN)63Ahmb/J
006553   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(H2-K1-tsA58)6Kio Tg(SMN2*delta7)4299Ahmb/J
008212   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(Prnp-SMN)92Ahmb/J
004623   STOCK Tg(TCF/Lef1-lacZ)34Efu/J
005493   STOCK Tg(Tek-rtTA,TRE-lacZ)1425Tpr/J
002395   STOCK Tg(Zfy1-lacZ)218Bri/J
003274   STOCK Tg(tetNZL)2Bjd/J
005728   STOCK Tg(tetO-Ipf1,lacZ)958.1Macd/J
View lacZ Expression Strains     (257 strains)

Strains carrying other alleles of lacZ
002484   129-Alpltm1Sor/J
002292   129-Gt(ROSA)26Sor/J
006050   129-Sirt6tm1Fwa/J
003451   129-Smad3tm1Par/J
003310   129S-Gt(ROSA)26Sortm1Sor/J
003383   129S-Nogtm1Amc/J
004545   129S-Npytm1Rpa/J
005091   129S-Pnpla6tm1Blw/J
007199   129S-Sgpl1Gt(ROSA)78Sor/J
003082   129S1/SvImJ-Bcl2tm1Mpin/J
010633   B6(Cg)-Gt(ROSA)26Sortm1(CAG-taulacZ)Bene/J
023757   B6(Cg)-Tg(tetO-tetX,lacZ)1Gogo/UmriJ
005085   B6.129(Cg)-Cd44tm1Hbg/J
012239   B6.129(Cg)-Cd44tm1Hbg/SjJ
004178   B6.129(Cg)-Tg(CAG-Bgeo/GFP)21Lbe/J
004478   B6.129-Foxd1tm1Lai/J
006939   B6.129-Fut1tm1Sdo/J
005768   B6.129-Htr5atm1Dgen/J
002938   B6.129-Kdrtm1Jrt/J
004158   B6.129-Maftm1Gsb/J
008233   B6.129-Nrgntm1Kph/J
006497   B6.129-Skiltm2Spw/J
005849   B6.129-Tmprss11atm1Dgen/J
009348   B6.129P2(Cg)-Hprttm17(Ple48-lacZ)Ems/Mmjax
012572   B6.129P2(Cg)-Hprttm19(Ple88-lacZ)Ems/Mmjax
012574   B6.129P2(Cg)-Hprttm38(Ple17-lacZ)Ems/Mmjax
012575   B6.129P2(Cg)-Hprttm39(Ple24-lacZ)Ems/Mmjax
012576   B6.129P2(Cg)-Hprttm40(Ple34-lacZ)Ems/Mmjax
010805   B6.129P2(Cg)-Hprttm41(Ple160-lacZ)Ems/Mmjax
012331   B6.129P2(Cg)-Hprttm42(Ple131-lacZ)Ems/Mmjax
012577   B6.129P2(Cg)-Hprttm43(Ple140-lacZ)Ems/Mmjax
010709   B6.129P2(Cg)-Hprttm44(Ple49-lacZ)Ems/Mmjax
012333   B6.129P2(Cg)-Hprttm45(Ple67-lacZ)Ems/Mmjax
012733   B6.129P2(Cg)-Hprttm53(CAG-lacZ)Ems/Mmjax
012578   B6.129P2(Cg)-Hprttm56(Ple25-lacZ)Ems/Mmjax
012579   B6.129P2(Cg)-Hprttm58(Ple119-lacZ)Ems/Mmjax
012580   B6.129P2(Cg)-Hprttm59(Ple123-lacZ)Ems/Mmjax
012581   B6.129P2(Cg)-Hprttm62(Ple153-lacZ)Ems/Mmjax
012342   B6.129P2(Cg)-Hprttm63(Ple12-lacZ)Ems/Mmjax
012347   B6.129P2(Cg)-Hprttm64(Ple170-lacZ)Ems/Mmjax
012582   B6.129P2(Cg)-Hprttm67(Ple238-lacZ)Ems/Mmjax
012583   B6.129P2(Cg)-Hprttm68(Ple127-lacZ)Ems/Mmjax
012656   B6.129P2(Cg)-Hprttm70(Ple240-lacZ)Ems/Mmjax
012657   B6.129P2(Cg)-Hprttm71(Ple155-lacZ)Ems/Mmjax
012659   B6.129P2(Cg)-Hprttm73(Ple142-lacZ)Ems/Mmjax
012734   B6.129P2(Cg)-Hprttm74(Ple232-lacZ)Ems/Mmjax
010921   B6.129P2(Cg)-Smn1tm1Msd/J
008235   B6.129P2-Abcg5tm1Plo/J
005772   B6.129P2-Acvrl1tm1Dgen/J
005770   B6.129P2-Adamts4tm1Dgen/J
005771   B6.129P2-Adamts5tm1Dgen/J
005773   B6.129P2-Adcy3tm1Dgen/J
005774   B6.129P2-Adcy7tm1Dgen/J
005775   B6.129P2-Adipor2tm1Dgen/J
005776   B6.129P2-Avpr1atm1Dgen/J
009120   B6.129P2-Axin2tm1Wbm/J
005777   B6.129P2-Axltm1Dgen/J
005783   B6.129P2-Cacna1ctm1Dgen/J
005780   B6.129P2-Cacna2d3tm1Dgen/J
005781   B6.129P2-Cacng3tm1Dgen/J
005782   B6.129P2-Cacng4tm1Dgen/J
005784   B6.129P2-Capn5tm1Dgen/J
005785   B6.129P2-Capn7tm1Dgen/J
005792   B6.129P2-Ccr1l1tm1Dgen/J
005793   B6.129P2-Ccr6tm1Dgen/J
005794   B6.129P2-Ccr7tm1Dgen/J
005779   B6.129P2-Celsr2tm1Dgen/J
005797   B6.129P2-Chrna2tm1Dgen/J
007566   B6.129P2-Clip2tm1.1Gal/J
005787   B6.129P2-Ctsctm1Dgen/J
005796   B6.129P2-Cxcr3tm1Dgen/J
005798   B6.129P2-Drd5tm1Dgen/J
005800   B6.129P2-Efemp2tm1Dgen/J
005801   B6.129P2-Esrratm1Dgen/J
005802   B6.129P2-Faim2tm1Dgen/J
005803   B6.129P2-Fzd1tm1Dgen/J
005804   B6.129P2-Fzd8tm1Dgen/J
005811   B6.129P2-Gabra3tm1Dgen/J
005812   B6.129P2-Gabra4tm1Dgen/J
005810   B6.129P2-Gabrptm1Dgen/J
005809   B6.129P2-Galr1tm1Dgen/J
005816   B6.129P2-Glra3tm1Dgen/J
005805   B6.129P2-Gpr151tm1Dgen/J
005806   B6.129P2-Gpr37tm1Dgen/J
005807   B6.129P2-Gpr6tm1Dgen/J
005813   B6.129P2-Grik5tm1Dgen/J
005808   B6.129P2-Grk5tm1Dgen/J
005814   B6.129P2-Grm1tm1Dgen/J
005815   B6.129P2-Grm3tm1Dgen/J
005817   B6.129P2-Gsk3btm1Dgen/J
005818   B6.129P2-Hcrtr1tm1Dgen/J
005767   B6.129P2-Htr4tm1Dgen/J
005769   B6.129P2-Htr7tm1Dgen/J
005821   B6.129P2-Lats2tm1Dgen/J
005822   B6.129P2-Lmbr1tm1Dgen/J
005850   B6.129P2-Mapkapk2tm1Dgen/J
005824   B6.129P2-Mmp17tm1Dgen/J
005825   B6.129P2-Mtmr1tm1Dgen/J
005826   B6.129P2-Ntsr1tm1Dgen/J
005829   B6.129P2-Pkd2l2tm1Dgen/J
005828   B6.129P2-Ppardtm1Dgen/J
005831   B6.129P2-Ppm1ftm1Dgen/J
005827   B6.129P2-Ptch2tm1Dgen/J
005832   B6.129P2-Ptprotm1Dgen/J
005799   B6.129P2-S1pr4tm1Dgen/J
005837   B6.129P2-Scn11atm1Dgen/J
005836   B6.129P2-Scn9atm1Dgen/J
005834   B6.129P2-Sema5atm1Dgen/J
005835   B6.129P2-Sema6ctm1Dgen/J
006432   B6.129P2-Slc18a1tm1Dgen/J
005839   B6.129P2-Slc22a12tm1Dgen/J
005838   B6.129P2-Slc22a6tm1Dgen/J
005840   B6.129P2-Slc40a1tm1Dgen/J
005841   B6.129P2-Slc6a9tm1Dgen/J
005842   B6.129P2-Slc7a8tm1Dgen/J
005843   B6.129P2-Slc9a6tm1Dgen/J
005844   B6.129P2-Sstr1tm1Dgen/J
005847   B6.129P2-Tgfbr1tm1Dgen/J
005845   B6.129P2-Thbs4tm1Dgen/J
005790   B6.129P2-Tpp1tm1Dgen/J
005848   B6.129P2-Trpm5tm1Dgen/J
005791   B6.129P2-Xcr1tm1Dgen/J
012377   B6.129S-Cyp19a1tm1.1Shah/J
009089   B6.129S1(Cg)-Ndntm2Stw/J
009387   B6.129S1-Osr1tm1Jian/J
009386   B6.129S1-Osr2tm1Jian/J
010617   B6.129S1-Snai2tm1Grid/J
003474   B6.129S4-Gt(ROSA)26Sortm1Sor/J
006142   B6.129S4-Ppargtm1Rev/J
003754   B6.129S4-Shroom3Gt(ROSA53)Sor/J
005119   B6.129S6-Npas2tm1Slm/J
002741   B6.129S7-Alpltm1Sor/J
005970   B6.129S7-Atoh1tm2Hzo/J
006039   B6.129S7-Efnb2tm1And/J
002192   B6.129S7-Gt(ROSA)26Sor/J
005981   B6.129S7-Rai1tm1Jrl/J
005039   B6.129X1-Adra1atm1Pcs/J
006262   B6.129X1-Fut2tm1Sdo/J
025101   B6.Cg-Avpr1atm1Dgen Tg(AVPR1A)1Bux/BuxJ
014536   B6.Cg-Hprttm75(Ple143-lacZ)Ems/Mmjax
007745   B6.Cg-Mir155tm1.1Rsky/J
003139   B6.Cg-Tg(DBHn-lacZ)8Rpk/J
006229   B6.Cg-Tg(DRE-lacZ)2Gswz/J
024050   B6.Cg-Tg(Hmgcr-lacZ)H253Sest/J
008629   B6.Cg-Tg(SMN2)11Tro Smn1tm1Msd/J
008631   B6.Cg-Tg(SMN2)11Tro Tg(SMN2)46Tro Smn1tm1Msd/J
008630   B6.Cg-Tg(SMN2)46Tro Smn1tm1Msd/J
007222   B6.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN1*A2G)2023Ahmb/J
006964   B6.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
006773   B6.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd/J
024377   B6.Cg-Tg(TCF/Lef1-lacZ)34Efu/KatmJ
009136   B6.Cg-Tg(tetO-Kcnj2,lacZ)1Gogo/J
002982   B6.Cg-Tg(xstpx-lacZ)32And/J
018625   B6.FVB-Tg(Fabp4-lacZ)4Mosh/J
008615   B6;129-Frzbtm1Nat/J
008621   B6;129-Fzd5tm1Nat/J
016857   B6;129-Itga7tm1Burk/J
005064   B6;129-Slc30a3tm1Rpa/J
009599   B6;129P2-Adam19Gt(Betageo)1Bbl/J
006431   B6;129P2-Adam21tm1Dgen/J
005788   B6;129P2-Cd97tm1Dgen/J
008590   B6;129P2-Cxcl14tm1Litt/J
006703   B6;129P2-Gucy2dtm1Mom/MomJ
021162   B6;129P2-Mapttm2Arbr/J
006665   B6;129P2-Olfr151tm13(rI7)Mom/MomJ
006666   B6;129P2-Olfr151tm24(Olfr2)Mom/MomJ
005833   B6;129P2-Rgs4tm1Dgen/J
002073   B6;129S-Gt(ROSA)26Sor/J
006470   B6;129S-Hopxtm1Eno/J
004153   B6;129S-Map7Gt(ROSABetageo)1Sor/J
006958   B6;129S-Nkd1tm1Kwha/J
006960   B6;129S-Nkd2tm1Kwha/J
010619   B6;129S1-Lfngtm1Grid/J
007208   B6;129S4-Csrnp1Gt(ROSA)80Sor/J
011052   B6;129S4-Ctbp2Gt(ROSA61)Sor/J
003309   B6;129S4-Gt(ROSA)26Sortm1Sor/J
007207   B6;129S4-Zfp640Gt(ROSA)81Sor/J
004365   B6;129S6-Srebf1tm1Mbr/J
002317   B6;129S7-Alpltm1Sor/J
003266   B6;129S7-Epas1tm1Rus/J
006044   B6;129S7-Ephb4tm1And/J
012436   B6;129S7-Tg(CAG-lacZ,-BMPR1A*,-EGFP)1Mis/Mmjax
008618   B6;A-Tg(OPN1LW-lacZ)1Nat/J
006465   B6;CBA-Tg(CAG-lacZ-WGA)330Bbm/J
007975   B6;CBA-Tg(OR8A1-taulacZ)1Mom/MomJ
007972   B6;CBA-Tg(Olfr151-taulacZ)4Mom/MomJ
006680   B6;CBA-Tg(Olfr16*,taulacZ)19Mom/MomJ
006671   B6;CBA-Tg(Olfr16*,taulacZ)5Mom/MomJ
006672   B6;CBA-Tg(Olfr16*,taulacZ)7Mom/MomJ
006673   B6;CBA-Tg(Olfr16,taulacZ)sn2Mom/MomJ
007973   B6;CBA-Tg(Olfr16-taulacZ)1Mom/MomJ
007974   B6;CBA-Tg(Olfr160-taulacZ)V4-7Mom/MomJ
007976   B6;CBA-Tg(Olfr713-taulacZ)4Mom/MomJ
006743   B6;CBA-Tg(P-taulacZ)11Mom/MomJ
006793   B6;CBA-Tg(P-taulacZ)13Mom/MomJ
006742   B6;CBA-Tg(P-taulacZ)8Mom/MomJ
004141   B6;CBA-Tg(UAS-lacZ)65Rth/J
008344   B6;DBA-Tg(Fos-tTA,Fos-EGFP*)1Mmay Tg(tetO-lacZ,tTA*)1Mmay/J
018627   B6;SJL-Tg(Myl1-lacZ)1Ibdml/J
026216   B6;SJL-Tg(Tnnt2-lacZ)497Jl/J
002369   B6;SJL-Tg(c177-lacZ)226Bri/J
002372   B6;SJL-Tg(c177-lacZ)227Bri/J
002621   B6;SJL-Tg(tetop-lacZ)2Mam/J
003299   B6;SWJ-Tg(TIMP3-lacZ)7Jeb/J
002865   B6CBA-Tg(Wnt1-lacZ)206Amc/J
019101   B6N.129S4(B6)-Gt(ROSA)26Sortm1Sor/CjDswJ
018913   B6N.Cg-Tg(tetO-GFP,-lacZ)G3Rsp/J
002955   C.129S7-Gt(ROSA)26Sor/J
009062   C57BL/6-Magel2tm1Stw/J
017955   C57BL/6-Tg(Gfap-rtTA,tetO-MAOB,-lacZ)1Jkan/J
002754   C57BL/6-Tg(LacZpl)60Vij/J
013729   C57BL/6-Tg(tetO-EDN1,-lacZ)9Mhus/J
013728   C57BL/6-Tg(tetO-NOS2,-lacZ)240iMhus/J
002193   C57BL/6J-Tg(MTn-lacZ)204Bri/J
005420   C;129S7 Gt(ROSA)26Sor-Bmp5cfe-se7J/GrsrJ
002981   DBA/2-Tg(xstpx-lacZ)36And/J
017333   FVB-Tg(tetO-Gnai2*,-lacZ)382Kndl/J
007225   FVB.129(B6)-Usp18tm1Dzh/J
006214   FVB.129P2-Smn1tm1Msd/J
009427   FVB.129S4(B6)-Gt(ROSA)26Sortm1Sor/J
012429   FVB.Cg-Gt(ROSA)26Sortm1(CAG-lacZ,-EGFP)Glh/J
008206   FVB.Cg-Smn1tm1Msd Tg(SMN2)566Ahmb/J
008209   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(ACTA1-SMN)69Ahmb/J
016573   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(S100B-EGFP)1Wjt Tg(SMN2*delta7)4299Ahmb/J
007968   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN1*A2G)2023Ahmb/2J
008782   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*A111G)588Ahmb/J
009134   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*A111G)591Ahmb/J
007952   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/2J
005025   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
005026   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN1*A2G)2023Ahmb/J
007949   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd/2J
005024   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd/J
003487   FVB.Cg-Tg(XGFAP-lacZ)3Mes/J
003140   FVB/N-Tg(PAI1-lacZ)1Jjb/J
002856   FVB/N-Tg(TIE2-lacZ)182Sato/J
005941   FVB/N-Tg(tetO-Aurkb,lacZ)41Kra/J
003315   FVB/N-Tg(tetORo1-lacZ)3Conk/J
005878   NOD.129(Cg)-Cd44tm1Hbg/J
003899   STOCK Cd44tm1Hbg/J
008602   STOCK Cdontm2Rsk/J
007912   STOCK En1tm2Alj/J
007925   STOCK En2tm5.1Alj/J
008211   STOCK Gli1tm2Alj/J
007922   STOCK Gli2tm2.1Alj/J
017596   STOCK Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb Tg(tetO-SMN2,-luc)#aAhmb/J
017597   STOCK Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb Tg(tetO-SMN2,-luc)#bAhmb/J
024746   STOCK Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy Hprttm1(tetO-Dkk1)Spdl Tg(TCF/Lef1-lacZ)34Efu/J
006241   STOCK Hhiptm1Amc/J
010707   STOCK Hprttm37(lacZ)Ems/Mmjax
012335   STOCK Hprttm50(Ple55-lacZ)Ems/Mmjax
013764   STOCK Hprttm57(Ple26-lacZ)Ems/Mmjax
012353   STOCK Hprttm65(Ple53-lacZ)Ems/Mmjax
012354   STOCK Hprttm66(Ple5-lacZ)Ems/Mmjax
012584   STOCK Hprttm69(Ple134-lacZ)Ems/Mmjax
007022   STOCK Mnx1tm4(cre)Tmj Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
006578   STOCK Myoz2tm1Eno/J
006646   STOCK Olfr151tm11(Olfr160)Mom/MomJ
006645   STOCK Olfr151tm12(Olfr16)Mom/MomJ
006691   STOCK Olfr151tm14(Adrb2)Mom/MomJ
006635   STOCK Olfr151tm15(V1rb2)Mom/MomJ
006630   STOCK Olfr151tm1Mom/MomJ
006629   STOCK Olfr151tm2Mom/MomJ
006628   STOCK Olfr151tm3Mom/MomJ
006740   STOCK Olfr160tm1(Olfr151)Mom Tg(Olfr151,taulacZ)AMom/MomJ
006741   STOCK Olfr160tm1(Olfr151)Mom Tg(Olfr151,taulacZ)BMom/MomJ
006651   STOCK Olfr17tm4Mom/MomJ
005707   STOCK Rag1tm1Mom Tg(TIE2-lacZ)182Sato/J
006633   STOCK Vmn1r49tm3Mom/MomJ
006634   STOCK Vmn1r49tm4(Olfr151)Mom/MomJ
014092   STOCK Tg(ACTB-tTA2,-MAPT/lacZ)1Luo/J
006613   STOCK Tg(CAG-Bgeo,-Tle1,-ALPP)1Lbe/J
003920   STOCK Tg(CAG-Bgeo/GFP)21Lbe/J
006674   STOCK Tg(Olfr16,taulacZ)2030Mom/MomJ
008477   STOCK Tg(RARE-Hspa1b/lacZ)12Jrt/J
008203   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(ACTA1-SMN)63Ahmb/J
006553   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(H2-K1-tsA58)6Kio Tg(SMN2*delta7)4299Ahmb/J
006570   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(Hlxb9-GFP)1Tmj/J
008212   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(Prnp-SMN)92Ahmb/J
018916   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN1-SMN2*)16Cll/CllJ
004623   STOCK Tg(TCF/Lef1-lacZ)34Efu/J
005493   STOCK Tg(Tek-rtTA,TRE-lacZ)1425Tpr/J
002395   STOCK Tg(Zfy1-lacZ)218Bri/J
003274   STOCK Tg(tetNZL)2Bjd/J
005728   STOCK Tg(tetO-Ipf1,lacZ)958.1Macd/J
View Strains carrying other alleles of lacZ     (284 strains)

Additional Web Information

Fluorescent Proteins/lacZ Systems

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Tg(BAT-lacZ)3Picc/Tg(BAT-lacZ)3Picc

        involves: C57BL/6 * DBA/2
  • normal phenotype
  • no abnormal phenotype detected
    • homozygotes are viable, fertile and display no gross physical or behavioral abnormalities   (MGI Ref ID J:82727)
    • transgene gives a read-out of beta-catenin activity by expression of beta-galactosidase; expression is initially detectable at E6 in posterior side of proximal epiblast and is observed in the posterior primitive streak and node at gastrulation, progressing to the paraxial mesoderm and notochord   (MGI Ref ID J:82727)
    • expression in developing and adult tissues mimics the pattern of Wnt signaling   (MGI Ref ID J:82727)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Cell Biology Research
Signal Transduction

Developmental Biology Research
Cell Motility Defects
Defects in Cell Adhesion Molecules
Defects in Extracellular Matrix Molecules
Growth Defects
Internal/Organ Defects
Limb Patterning Defects
Mesodermal Defects
Neural Crest Defects
Neurodevelopmental Defects
Skeletal Defects

Neurobiology Research
lacZ expression in neural tissue
Neurodevelopmental Defects

Research Tools
lacZ Expression
Developmental Biology Research
Genetics Research
      Tissue/Cell Markers
      Tissue/Cell Markers: neurons
Neurobiology Research
      cell marker

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Tg(BAT-lacZ)3Picc
Allele Name transgene insertion 3, Stefano Piccolo
Allele Type Transgenic (Reporter)
Common Name(s) BAT-gal; BAT::gal; BATnlacZ; BATGAL;
Strain of Origin(C57BL/6 x DBA/2)F2
Site of Expressionbeta-galactosidase activity in developing and adult nervous tissue mimics the pattern of Wnt signaling
Expressed Gene lacZ, beta-galactosidase, E. coli
Promoter siamois, siamois gene minimal promoter, Xenopus,
General Note This is one of three "BAT-gal" transgenic lines generated, which the authors state exhibitied "qualitatively identical expression patterns, although quantitative differences could be observed."
Molecular Note Mice with this transgene express nuclear beta-galactosidase under control of the beta-catenin-activated transgene (BAT) promoter. This promoter consists of a DNA fragment extending 0.13 kb upstream from the translation start site of the novel protein containing homeodomain (siamois) gene of Xenopus laevis, which contains the (beta-catenin non-responsive) minimal promoter of this natively beta-catenin activated gene, downstream of seven synthetic lymphoid enhancer factor/T-cell factor- (LEF/TCF-) binding sites that effectively restore the promoter's beta-catenin responsiveness. The transgene does not segregate randomly with respect to the Jup locus indicating that the transgene insertion site is genetically linked to Jup. [MGI Ref ID J:82727]
 
 

Genotyping

Genotyping Information

Genotyping Protocols

Generic LacZ Melt Curve Analysis, Melt Curve Analysis
Generic LacZ QPCR, QPCR
Generic LacZ, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Maretto S; Cordenonsi M; Dupont S; Braghetta P; Broccoli V; Hassan AB; Volpin D; Bressan GM; Piccolo S. 2003. Mapping Wnt/beta-catenin signaling during mouse development and in colorectal tumors. Proc Natl Acad Sci U S A 100(6):3299-304. [PubMed: 12626757]  [MGI Ref ID J:82727]

Additional References

Tg(BAT-lacZ)3Picc related

Akiyama R; Kawakami H; Taketo MM; Evans SM; Wada N; Petryk A; Kawakami Y. 2014. Distinct populations within Isl1 lineages contribute to appendicular and facial skeletogenesis through the beta-catenin pathway. Dev Biol 387(1):37-48. [PubMed: 24424161]  [MGI Ref ID J:207610]

Al Alam D; Green M; Tabatabai Irani R; Parsa S; Danopoulos S; Sala FG; Branch J; El Agha E; Tiozzo C; Voswinckel R; Jesudason EC; Warburton D; Bellusci S. 2011. Contrasting expression of canonical Wnt signaling reporters TOPGAL, BATGAL and Axin2(LacZ) during murine lung development and repair. PLoS One 6(8):e23139. [PubMed: 21858009]  [MGI Ref ID J:176498]

Andoniadou CL; Signore M; Young RM; Gaston-Massuet C; Wilson SW; Fuchs E; Martinez-Barbera JP. 2011. HESX1- and TCF3-mediated repression of Wnt/beta-catenin targets is required for normal development of the anterior forebrain. Development 138(22):4931-42. [PubMed: 22007134]  [MGI Ref ID J:181005]

Aulehla A; Wiegraebe W; Baubet V; Wahl MB; Deng C; Taketo M; Lewandoski M; Pourquie O. 2008. A beta-catenin gradient links the clock and wavefront systems in mouse embryo segmentation. Nat Cell Biol 10(2):186-93. [PubMed: 18157121]  [MGI Ref ID J:132361]

Beites CL; Hollenbeck PL; Kim J; Lovell-Badge R; Lander AD; Calof AL. 2009. Follistatin modulates a BMP autoregulatory loop to control the size and patterning of sensory domains in the developing tongue. Development 136(13):2187-97. [PubMed: 19474151]  [MGI Ref ID J:149988]

Berbari NF; Kin NW; Sharma N; Michaud EJ; Kesterson RA; Yoder BK. 2011. Mutations in Traf3ip1 reveal defects in ciliogenesis, embryonic development, and altered cell size regulation. Dev Biol 360(1):66-76. [PubMed: 21945076]  [MGI Ref ID J:178483]

Bloomekatz J; Grego-Bessa J; Migeotte I; Anderson KV. 2012. Pten regulates collective cell migration during specification of the anterior-posterior axis of the mouse embryo. Dev Biol 364(2):192-201. [PubMed: 22342906]  [MGI Ref ID J:183946]

Bluske KK; Kawakami Y; Koyano-Nakagawa N; Nakagawa Y. 2009. Differential activity of Wnt/beta-catenin signaling in the embryonic mouse thalamus. Dev Dyn 238(12):3297-3309. [PubMed: 19924825]  [MGI Ref ID J:154363]

Bluske KK; Vue TY; Kawakami Y; Taketo MM; Yoshikawa K; Johnson JE; Nakagawa Y. 2012. beta-Catenin signaling specifies progenitor cell identity in parallel with Shh signaling in the developing mammalian thalamus. Development 139(15):2692-702. [PubMed: 22745311]  [MGI Ref ID J:185651]

Borello U; Cobos I; Long JE; McWhirter JR; Murre C; Rubenstein JL. 2008. FGF15 promotes neurogenesis and opposes FGF8 function during neocortical development. Neural Dev 3:17. [PubMed: 18625063]  [MGI Ref ID J:160580]

Boulday G; Rudini N; Maddaluno L; Blecon A; Arnould M; Gaudric A; Chapon F; Adams RH; Dejana E; Tournier-Lasserve E. 2011. Developmental timing of CCM2 loss influences cerebral cavernous malformations in mice. J Exp Med 208(9):1835-47. [PubMed: 21859843]  [MGI Ref ID J:177584]

Bridgewater D; Cox B; Cain J; Lau A; Athaide V; Gill PS; Kuure S; Sainio K; Rosenblum ND. 2008. Canonical WNT/beta-catenin signaling is required for ureteric branching. Dev Biol 317(1):83-94. [PubMed: 18358465]  [MGI Ref ID J:136068]

Buchert M; Athineos D; Abud HE; Burke ZD; Faux MC; Samuel MS; Jarnicki AG; Winbanks CE; Newton IP; Meniel VS; Suzuki H; Stacker SA; Nathke IS; Tosh D; Huelsken J; Clarke AR; Heath JK; Sansom OJ; Ernst M. 2010. Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo. PLoS Genet 6(1):e1000816. [PubMed: 20084116]  [MGI Ref ID J:156864]

Burn SF; Webb A; Berry RL; Davies JA; Ferrer-Vaquer A; Hadjantonakis AK; Hastie ND; Hohenstein P. 2011. Calcium/NFAT signalling promotes early nephrogenesis. Dev Biol 352(2):288-98. [PubMed: 21295565]  [MGI Ref ID J:171469]

Cantu C; Valenta T; Hausmann G; Vilain N; Aguet M; Basler K. 2013. The Pygo2-H3K4me2/3 interaction is dispensable for mouse development and Wnt signaling-dependent transcription. Development 140(11):2377-86. [PubMed: 23637336]  [MGI Ref ID J:198562]

Chen F; Cao Y; Qian J; Shao F; Niederreither K; Cardoso WV. 2010. A retinoic acid-dependent network in the foregut controls formation of the mouse lung primordium. J Clin Invest 120(6):2040-8. [PubMed: 20484817]  [MGI Ref ID J:161637]

Chilov D; Sinjushina N; Saarimaki-Vire J; Taketo MM; Partanen J. 2010. beta-Catenin regulates intercellular signalling networks and cell-type specific transcription in the developing mouse midbrain-rhombomere 1 region. PLoS One 5(6):e10881. [PubMed: 20532162]  [MGI Ref ID J:161813]

Cohen ED; Ihida-Stansbury K; Lu MM; Panettieri RA; Jones PL; Morrisey EE. 2009. Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway. J Clin Invest 119(9):2538-49. [PubMed: 19690384]  [MGI Ref ID J:152705]

Cohen ED; Miller MF; Wang Z; Moon RT; Morrisey EE. 2012. Wnt5a and Wnt11 are essential for second heart field progenitor development. Development 139(11):1931-40. [PubMed: 22569553]  [MGI Ref ID J:184511]

Cohen ED; Wang Z; Lepore JJ; Lu MM; Taketo MM; Epstein DJ; Morrisey EE. 2007. Wnt/beta-catenin signaling promotes expansion of Isl-1-positive cardiac progenitor cells through regulation of FGF signaling. J Clin Invest 117(7):1794-804. [PubMed: 17607356]  [MGI Ref ID J:124189]

Collette NM; Genetos DC; Murugesh D; Harland RM; Loots GG. 2010. Genetic evidence that SOST inhibits WNT signaling in the limb. Dev Biol 342(2):169-79. [PubMed: 20359476]  [MGI Ref ID J:161416]

Corbit KC; Shyer AE; Dowdle WE; Gaulden J; Singla V; Reiter JF. 2008. Kif3a constrains beta-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms. Nat Cell Biol 10(1):70-6. [PubMed: 18084282]  [MGI Ref ID J:132369]

Cui C; Chatterjee B; Lozito TP; Zhang Z; Francis RJ; Yagi H; Swanhart LM; Sanker S; Francis D; Yu Q; San Agustin JT; Puligilla C; Chatterjee T; Tansey T; Liu X; Kelley MW; Spiliotis ET; Kwiatkowski AV; Tuan R; Pazour GJ; Hukriede NA; Lo CW. 2013. Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton. PLoS Biol 11(11):e1001720. [PubMed: 24302887]  [MGI Ref ID J:205269]

Cui Y; Niziolek PJ; Macdonald BT; Zylstra CR; Alenina N; Robinson DR; Zhong Z; Matthes S; Jacobsen CM; Conlon RA; Brommage R; Liu Q; Mseeh F; Powell DR; Yang QM; Zambrowicz B; Gerrits H; Gossen JA; He X; Bader M; Williams BO; Warman ML; Robling AG. 2011. Lrp5 functions in bone to regulate bone mass. Nat Med 17(6):684-91. [PubMed: 21602802]  [MGI Ref ID J:172746]

Davis RB; Curtis CD; Griffin CT. 2013. BRG1 promotes COUP-TFII expression and venous specification during embryonic vascular development. Development 140(6):1272-81. [PubMed: 23406903]  [MGI Ref ID J:194470]

Demireva EY; Shapiro LS; Jessell TM; Zampieri N. 2011. Motor neuron position and topographic order imposed by beta- and gamma-catenin activities. Cell 147(3):641-52. [PubMed: 22036570]  [MGI Ref ID J:178688]

Donaldson IJ; Amin S; Hensman JJ; Kutejova E; Rattray M; Lawrence N; Hayes A; Ward CM; Bobola N. 2012. Genome-wide occupancy links Hoxa2 to Wnt-beta-catenin signaling in mouse embryonic development. Nucleic Acids Res 40(9):3990-4001. [PubMed: 22223247]  [MGI Ref ID J:197726]

Du J; Takeuchi H; Leonhard-Melief C; Shroyer KR; Dlugosz M; Haltiwanger RS; Holdener BC. 2010. O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. Dev Biol 346(1):25-38. [PubMed: 20637190]  [MGI Ref ID J:165751]

Etheridge SL; Ray S; Li S; Hamblet NS; Lijam N; Tsang M; Greer J; Kardos N; Wang J; Sussman DJ; Chen P; Wynshaw-Boris A. 2008. Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development. PLoS Genet 4(11):e1000259. [PubMed: 19008950]  [MGI Ref ID J:142392]

Faedo A; Tomassy GS; Ruan Y; Teichmann H; Krauss S; Pleasure SJ; Tsai SY; Tsai MJ; Studer M; Rubenstein JL. 2008. COUP-TFI coordinates cortical patterning, neurogenesis, and laminar fate and modulates MAPK/ERK, AKT, and beta-catenin signaling. Cereb Cortex 18(9):2117-31. [PubMed: 18165280]  [MGI Ref ID J:146820]

Fancy SP; Baranzini SE; Zhao C; Yuk DI; Irvine KA; Kaing S; Sanai N; Franklin RJ; Rowitch DH. 2009. Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS. Genes Dev 23(13):1571-85. [PubMed: 19515974]  [MGI Ref ID J:150044]

Ferretti E; Li B; Zewdu R; Wells V; Hebert JM; Karner C; Anderson MJ; Williams T; Dixon J; Dixon MJ; Depew MJ; Selleri L. 2011. A conserved Pbx-Wnt-p63-Irf6 regulatory module controls face morphogenesis by promoting epithelial apoptosis. Dev Cell 21(4):627-41. [PubMed: 21982646]  [MGI Ref ID J:178316]

Fossat N; Jones V; Khoo PL; Bogani D; Hardy A; Steiner K; Mukhopadhyay M; Westphal H; Nolan PM; Arkell R; Tam PP. 2011. Stringent requirement of a proper level of canonical WNT signalling activity for head formation in mouse embryo. Development 138(4):667-76. [PubMed: 21228006]  [MGI Ref ID J:170646]

Fotaki V; Price DJ; Mason JO. 2011. Wnt/beta-catenin signaling is disrupted in the extra-toes (Gli3(Xt/Xt) ) mutant from early stages of forebrain development, concomitant with anterior neural plate patterning defects. J Comp Neurol 519(9):1640-57. [PubMed: 21452227]  [MGI Ref ID J:174727]

Fotaki V; Smith R; Pratt T; Price DJ. 2013. Foxg1 is required to limit the formation of ciliary margin tissue and Wnt/beta-catenin signalling in the developing nasal retina of the mouse. Dev Biol 380(2):299-313. [PubMed: 23624311]  [MGI Ref ID J:199602]

Fujimura N; Taketo MM; Mori M; Korinek V; Kozmik Z. 2009. Spatial and temporal regulation of Wnt/beta-catenin signaling is essential for development of the retinal pigment epithelium. Dev Biol 334(1):31-45. [PubMed: 19596317]  [MGI Ref ID J:153566]

Gaillard D; Barlow LA. 2011. Taste bud cells of adult mice are responsive to Wnt/beta-catenin signaling: Implications for the renewal of mature taste cells. Genesis 49(4):295-306. [PubMed: 21328519]  [MGI Ref ID J:171517]

Gaston-Massuet C; Andoniadou CL; Signore M; Jayakody SA; Charolidi N; Kyeyune R; Vernay B; Jacques TS; Taketo MM; Le Tissier P; Dattani MT; Martinez-Barbera JP. 2011. From the Cover: Increased Wingless (Wnt) signaling in pituitary progenitor/stem cells gives rise to pituitary tumors in mice and humans. Proc Natl Acad Sci U S A 108(28):11482-7. [PubMed: 21636786]  [MGI Ref ID J:174144]

Gilbert LC; Chen H; Lu X; Nanes MS. 2013. Chronic low dose tumor necrosis factor-alpha (TNF) suppresses early bone accrual in young mice by inhibiting osteoblasts without affecting osteoclasts. Bone 56(1):174-83. [PubMed: 23756233]  [MGI Ref ID J:203629]

Goss AM; Tian Y; Cheng L; Yang J; Zhou D; Cohen ED; Morrisey EE. 2011. Wnt2 signaling is necessary and sufficient to activate the airway smooth muscle program in the lung by regulating myocardin/Mrtf-B and Fgf10 expression. Dev Biol 356(2):541-52. [PubMed: 21704027]  [MGI Ref ID J:175454]

Goss AM; Tian Y; Tsukiyama T; Cohen ED; Zhou D; Lu MM; Yamaguchi TP; Morrisey EE. 2009. Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut. Dev Cell 17(2):290-8. [PubMed: 19686689]  [MGI Ref ID J:153098]

Goux D; Coudert JD; Maurice D; Scarpellino L; Jeannet G; Piccolo S; Weston K; Huelsken J; Held W. 2005. Cooperating pre-T-cell receptor and TCF-1-dependent signals ensure thymocyte survival. Blood 106(5):1726-33. [PubMed: 15890681]  [MGI Ref ID J:118496]

Griffin CT; Curtis CD; Davis RB; Muthukumar V; Magnuson T. 2011. The chromatin-remodeling enzyme BRG1 modulates vascular Wnt signaling at two levels. Proc Natl Acad Sci U S A 108(6):2282-7. [PubMed: 21262838]  [MGI Ref ID J:169096]

Grimsley-Myers CM; Sipe CW; Wu DK; Lu X. 2012. Redundant functions of Rac GTPases in inner ear morphogenesis. Dev Biol 362(2):172-86. [PubMed: 22182523]  [MGI Ref ID J:180774]

Hammerschmidt B; Schlake T. 2007. Localization of Shh expression by Wnt and Eda affects axial polarity and shape of hairs. Dev Biol 305(1):246-61. [PubMed: 17376426]  [MGI Ref ID J:121316]

Hashimoto S; Chen H; Que J; Brockway BL; Drake JA; Snyder JC; Randell SH; Stripp BR. 2012. beta-Catenin-SOX2 signaling regulates the fate of developing airway epithelium. J Cell Sci 125(Pt 4):932-42. [PubMed: 22421361]  [MGI Ref ID J:197815]

He F; Xiong W; Wang Y; Li L; Liu C; Yamagami T; Taketo MM; Zhou C; Chen Y. 2011. Epithelial Wnt/beta-catenin signaling regulates palatal shelf fusion through regulation of Tgfbeta3 expression. Dev Biol 350(2):511-9. [PubMed: 21185284]  [MGI Ref ID J:170579]

Hierholzer A; Kemler R. 2009. beta-catenin-mediated signaling and cell adhesion in postgastrulation mouse embryos. Dev Dyn 239(1):191-199. [PubMed: 19705445]  [MGI Ref ID J:155247]

Horner VL; Caspary T. 2011. Disrupted dorsal neural tube BMP signaling in the cilia mutant Arl13b hnn stems from abnormal Shh signaling. Dev Biol 355(1):43-54. [PubMed: 21539826]  [MGI Ref ID J:173637]

Ivaniutsin U; Chen Y; Mason JO; Price DJ; Pratt T. 2009. Adenomatous polyposis coli is required for early events in the normal growth and differentiation of the developing cerebral cortex. Neural Dev 4:3. [PubMed: 19149881]  [MGI Ref ID J:160733]

Jen YH; Musacchio M; Lander AD. 2009. Glypican-1 controls brain size through regulation of fibroblast growth factor signaling in early neurogenesis. Neural Dev 4:33. [PubMed: 19732411]  [MGI Ref ID J:159598]

Juan J; Muraguchi T; Iezza G; Sears RC; McMahon M. 2014. Diminished WNT -> beta-catenin -> c-MYC signaling is a barrier for malignant progression of BRAFV600E-induced lung tumors. Genes Dev 28(6):561-75. [PubMed: 24589553]  [MGI Ref ID J:209631]

Karalay O; Doberauer K; Vadodaria KC; Knobloch M; Berti L; Miquelajauregui A; Schwark M; Jagasia R; Taketo MM; Tarabykin V; Lie DC; Jessberger S. 2011. Prospero-related homeobox 1 gene (Prox1) is regulated by canonical Wnt signaling and has a stage-specific role in adult hippocampal neurogenesis. Proc Natl Acad Sci U S A 108(14):5807-12. [PubMed: 21436036]  [MGI Ref ID J:171216]

Kasberg AD; Brunskill EW; Steven Potter S. 2013. SP8 regulates signaling centers during craniofacial development. Dev Biol 381(2):312-23. [PubMed: 23872235]  [MGI Ref ID J:200761]

Kawakami Y; Marti M; Kawakami H; Itou J; Quach T; Johnson A; Sahara S; O'Leary DD; Nakagawa Y; Lewandoski M; Pfaff S; Evans SM; Izpisua Belmonte JC. 2011. Islet1-mediated activation of the beta-catenin pathway is necessary for hindlimb initiation in mice. Development 138(20):4465-73. [PubMed: 21937598]  [MGI Ref ID J:178771]

Kemler R; Hierholzer A; Kanzler B; Kuppig S; Hansen K; Taketo MM; de Vries WN; Knowles BB; Solter D. 2004. Stabilization of {beta}-catenin in the mouse zygote leads to premature epithelial-mesenchymal transition in the epiblast. Development 131(23):5817-5824. [PubMed: 15525667]  [MGI Ref ID J:94395]

Kim H; Kim T; Jeong BC; Cho IT; Han D; Takegahara N; Negishi-Koga T; Takayanagi H; Lee JH; Sul JY; Prasad V; Lee SH; Choi Y. 2013. Tmem64 modulates calcium signaling during RANKL-mediated osteoclast differentiation. Cell Metab 17(2):249-60. [PubMed: 23395171]  [MGI Ref ID J:198051]

Klimova L; Kozmik Z. 2014. Stage-dependent requirement of neuroretinal Pax6 for lens and retina development. Development 141(6):1292-302. [PubMed: 24523460]  [MGI Ref ID J:208421]

Kreslova J; Machon O; Ruzickova J; Lachova J; Wawrousek EF; Kemler R; Krauss S; Piatigorsky J; Kozmik Z. 2007. Abnormal lens morphogenesis and ectopic lens formation in the absence of beta-catenin function. Genesis 45(4):157-68. [PubMed: 17410548]  [MGI Ref ID J:121794]

Kumamoto N; Gu Y; Wang J; Janoschka S; Takemaru K; Levine J; Ge S. 2012. A role for primary cilia in glutamatergic synaptic integration of adult-born neurons. Nat Neurosci 15(3):399-405, S1. [PubMed: 22306608]  [MGI Ref ID J:182293]

Lancaster MA; Gopal DJ; Kim J; Saleem SN; Silhavy JL; Louie CM; Thacker BE; Williams Y; Zaki MS; Gleeson JG. 2011. Defective Wnt-dependent cerebellar midline fusion in a mouse model of Joubert syndrome. Nat Med 17(6):726-31. [PubMed: 21623382]  [MGI Ref ID J:172420]

Lancaster MA; Schroth J; Gleeson JG. 2011. Subcellular spatial regulation of canonical Wnt signalling at the primary cilium. Nat Cell Biol 13(6):700-7. [PubMed: 21602792]  [MGI Ref ID J:174986]

Lang J; Maeda Y; Bannerman P; Xu J; Horiuchi M; Pleasure D; Guo F. 2013. Adenomatous polyposis coli regulates oligodendroglial development. J Neurosci 33(7):3113-30. [PubMed: 23407966]  [MGI Ref ID J:194259]

Larkins CE; Long AB; Caspary T. 2012. Defective Nodal and Cerl2 expression in the Arl13b(hnn) mutant node underlie its heterotaxia. Dev Biol 367(1):15-24. [PubMed: 22554696]  [MGI Ref ID J:185804]

Lewis SL; Khoo PL; De Young RA; Steiner K; Wilcock C; Mukhopadhyay M; Westphal H; Jamieson RV; Robb L; Tam PP. 2008. Dkk1 and Wnt3 interact to control head morphogenesis in the mouse. Development 135(10):1791-801. [PubMed: 18403408]  [MGI Ref ID J:134688]

Li B; Rheaume C; Teng A; Bilanchone V; Munguia JE; Hu M; Jessen S; Piccolo S; Waterman ML; Dai X. 2007. Developmental phenotypes and reduced Wnt signaling in mice deficient for pygopus 2. Genesis 45(5):318-25. [PubMed: 17458864]  [MGI Ref ID J:121776]

Li X; Shan J; Chang W; Kim I; Bao J; Lee HJ; Zhang X; Samuel VT; Shulman GI; Liu D; Zheng JJ; Wu D. 2012. Chemical and genetic evidence for the involvement of Wnt antagonist Dickkopf2 in regulation of glucose metabolism. Proc Natl Acad Sci U S A 109(28):11402-7. [PubMed: 22733757]  [MGI Ref ID J:186402]

Liebner S; Corada M; Bangsow T; Babbage J; Taddei A; Czupalla CJ; Reis M; Felici A; Wolburg H; Fruttiger M; Taketo MM; von Melchner H; Plate KH; Gerhardt H; Dejana E. 2008. Wnt/beta-catenin signaling controls development of the blood-brain barrier. J Cell Biol 183(3):409-17. [PubMed: 18955553]  [MGI Ref ID J:141415]

Lin C; Fisher AV; Yin Y; Maruyama T; Veith GM; Dhandha M; Huang GJ; Hsu W; Ma L. 2011. The inductive role of Wnt-beta-Catenin signaling in the formation of oral apparatus. Dev Biol 356(1):40-50. [PubMed: 21600200]  [MGI Ref ID J:175262]

Lin SL; Li B; Rao S; Yeo EJ; Hudson TE; Nowlin BT; Pei H; Chen L; Zheng JJ; Carroll TJ; Pollard JW; McMahon AP; Lang RA; Duffield JS. 2010. Macrophage Wnt7b is critical for kidney repair and regeneration. Proc Natl Acad Sci U S A 107(9):4194-9. [PubMed: 20160075]  [MGI Ref ID J:158579]

Lindvall C; Zylstra CR; Evans N; West RA; Dykema K; Furge KA; Williams BO. 2009. The Wnt co-receptor Lrp6 is required for normal mouse mammary gland development. PLoS One 4(6):e5813. [PubMed: 19503830]  [MGI Ref ID J:150203]

Liu F; Chu EY; Watt B; Zhang Y; Gallant NM; Andl T; Yang SH; Lu MM; Piccolo S; Schmidt-Ullrich R; Taketo MM; Morrisey EE; Atit R; Dlugosz AA; Millar SE. 2008. Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis. Dev Biol 313(1):210-24. [PubMed: 18022614]  [MGI Ref ID J:130228]

Liu W; Lagutin O; Swindell E; Jamrich M; Oliver G. 2010. Neuroretina specification in mouse embryos requires Six3-mediated suppression of Wnt8b in the anterior neural plate. J Clin Invest 120(10):3568-77. [PubMed: 20890044]  [MGI Ref ID J:165328]

Lorenz K; Grashoff C; Torka R; Sakai T; Langbein L; Bloch W; Aumailley M; Fassler R. 2007. Integrin-linked kinase is required for epidermal and hair follicle morphogenesis. J Cell Biol 177(3):501-13. [PubMed: 17485490]  [MGI Ref ID J:134724]

Love D; Li FQ; Burke MC; Cyge B; Ohmitsu M; Cabello J; Larson JE; Brody SL; Cohen JC; Takemaru K. 2010. Altered lung morphogenesis, epithelial cell differentiation and mechanics in mice deficient in the Wnt/beta-catenin antagonist Chibby. PLoS One 5(10):e13600. [PubMed: 21049041]  [MGI Ref ID J:166685]

Lu P; Yu Y; Perdue Y; Werb Z. 2008. The apical ectodermal ridge is a timer for generating distal limb progenitors. Development 135(8):1395-405. [PubMed: 18359901]  [MGI Ref ID J:136057]

Ma S; Kwon HJ; Johng H; Zang K; Huang Z. 2013. Radial glial neural progenitors regulate nascent brain vascular network stabilization via inhibition of Wnt signaling. PLoS Biol 11(1):e1001469. [PubMed: 23349620]  [MGI Ref ID J:194480]

Machon O; Backman M; Machonova O; Kozmik Z; Vacik T; Andersen L; Krauss S. 2007. A dynamic gradient of Wnt signaling controls initiation of neurogenesis in the mammalian cortex and cellular specification in the hippocampus. Dev Biol 311(1):223-37. [PubMed: 17916349]  [MGI Ref ID J:126323]

Machon O; Kreslova J; Ruzickova J; Vacik T; Klimova L; Fujimura N; Lachova J; Kozmik Z. 2010. Lens morphogenesis is dependent on Pax6-mediated inhibition of the canonical Wnt/beta-catenin signaling in the lens surface ectoderm. Genesis 48(2):86-95. [PubMed: 20027618]  [MGI Ref ID J:158407]

Maes C; Goossens S; Bartunkova S; Drogat B; Coenegrachts L; Stockmans I; Moermans K; Nyabi O; Haigh K; Naessens M; Haenebalcke L; Tuckermann JP; Tjwa M; Carmeliet P; Mandic V; David JP; Behrens A; Nagy A; Carmeliet G; Haigh JJ. 2010. Increased skeletal VEGF enhances beta-catenin activity and results in excessively ossified bones. EMBO J 29(2):424-41. [PubMed: 20010698]  [MGI Ref ID J:156474]

Manicassamy S; Reizis B; Ravindran R; Nakaya H; Salazar-Gonzalez RM; Wang YC; Pulendran B. 2010. Activation of beta-catenin in dendritic cells regulates immunity versus tolerance in the intestine. Science 329(5993):849-53. [PubMed: 20705860]  [MGI Ref ID J:163676]

Mao J; McKean DM; Warrier S; Corbin JG; Niswander L; Zohn IE. 2010. The iron exporter ferroportin 1 is essential for development of the mouse embryo, forebrain patterning and neural tube closure. Development 137(18):3079-88. [PubMed: 20702562]  [MGI Ref ID J:164587]

McBride JD; Jenkins AJ; Liu X; Zhang B; Lee K; Berry WL; Janknecht R; Griffin CT; Aston CE; Lyons TJ; Tomasek JJ; Ma JX. 2014. Elevated circulation levels of an antiangiogenic SERPIN in patients with diabetic microvascular complications impair wound healing through suppression of Wnt signaling. J Invest Dermatol 134(6):1725-34. [PubMed: 24463424]  [MGI Ref ID J:210841]

Migeotte I; Omelchenko T; Hall A; Anderson KV. 2010. Rac1-dependent collective cell migration is required for specification of the anterior-posterior body axis of the mouse. PLoS Biol 8(8):e1000442. [PubMed: 20689803]  [MGI Ref ID J:166095]

Munne PM; Tummers M; Jarvinen E; Thesleff I; Jernvall J. 2009. Tinkering with the inductive mesenchyme: Sostdc1 uncovers the role of dental mesenchyme in limiting tooth induction. Development 136(3):393-402. [PubMed: 19141669]  [MGI Ref ID J:144193]

Mutch CA; Funatsu N; Monuki ES; Chenn A. 2009. Beta-catenin signaling levels in progenitors influence the laminar cell fates of projection neurons. J Neurosci 29(43):13710-9. [PubMed: 19864583]  [MGI Ref ID J:158308]

Narhi K; Jarvinen E; Birchmeier W; Taketo MM; Mikkola ML; Thesleff I. 2008. Sustained epithelial {beta}-catenin activity induces precocious hair development but disrupts hair follicle down-growth and hair shaft formation. Development 135(6):1019-28. [PubMed: 18256193]  [MGI Ref ID J:131961]

Narhi K; Tummers M; Ahtiainen L; Itoh N; Thesleff I; Mikkola ML. 2012. Sostdc1 defines the size and number of skin appendage placodes. Dev Biol 364(2):149-61. [PubMed: 22509524]  [MGI Ref ID J:183911]

Nava P; Koch S; Laukoetter MG; Lee WY; Kolegraff K; Capaldo CT; Beeman N; Addis C; Gerner-Smidt K; Neumaier I; Skerra A; Li L; Parkos CA; Nusrat A. 2010. Interferon-gamma regulates intestinal epithelial homeostasis through converging beta-catenin signaling pathways. Immunity 32(3):392-402. [PubMed: 20303298]  [MGI Ref ID J:158902]

Norrmen C; Ivanov KI; Cheng J; Zangger N; Delorenzi M; Jaquet M; Miura N; Puolakkainen P; Horsley V; Hu J; Augustin HG; Yla-Herttuala S; Alitalo K; Petrova TV. 2009. FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1. J Cell Biol 185(3):439-57. [PubMed: 19398761]  [MGI Ref ID J:149138]

Ohazama A; Johnson EB; Ota MS; Choi HJ; Porntaveetus T; Oommen S; Itoh N; Eto K; Gritli-Linde A; Herz J; Sharpe PT. 2008. Lrp4 modulates extracellular integration of cell signaling pathways in development. PLoS ONE 3(12):e4092. [PubMed: 19116665]  [MGI Ref ID J:144348]

Ola R; Jakobson M; Kvist J; Perala N; Kuure S; Braunewell KH; Bridgewater D; Rosenblum ND; Chilov D; Immonen T; Sainio K; Sariola H. 2011. The GDNF target Vsnl1 marks the ureteric tip. J Am Soc Nephrol 22(2):274-84. [PubMed: 21289216]  [MGI Ref ID J:191040]

Osorio KM; Lilja KC; Tumbar T. 2011. Runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartments. J Cell Biol 193(1):235-50. [PubMed: 21464233]  [MGI Ref ID J:171374]

Pereira PN; Dobreva MP; Maas E; Cornelis FM; Moya IM; Umans L; Verfaillie CM; Camus A; de Sousa Lopes SM; Huylebroeck D; Zwijsen A. 2012. Antagonism of Nodal signaling by BMP/Smad5 prevents ectopic primitive streak formation in the mouse amnion. Development 139(18):3343-54. [PubMed: 22912414]  [MGI Ref ID J:187710]

Phng LK; Potente M; Leslie JD; Babbage J; Nyqvist D; Lobov I; Ondr JK; Rao S; Lang RA; Thurston G; Gerhardt H. 2009. Nrarp coordinates endothelial Notch and Wnt signaling to control vessel density in angiogenesis. Dev Cell 16(1):70-82. [PubMed: 19154719]  [MGI Ref ID J:144980]

Porntaveetus T; Ohazama A; Choi HY; Herz J; Sharpe PT. 2012. Wnt signaling in the murine diastema. Eur J Orthod 34(4):518-24. [PubMed: 21531785]  [MGI Ref ID J:186534]

Qian D; Jones C; Rzadzinska A; Mark S; Zhang X; Steel KP; Dai X; Chen P. 2007. Wnt5a functions in planar cell polarity regulation in mice. Dev Biol 306(1):121-33. [PubMed: 17433286]  [MGI Ref ID J:122585]

Reid BS; Yang H; Melvin VS; Taketo MM; Williams T. 2011. Ectodermal Wnt/beta-catenin signaling shapes the mouse face. Dev Biol 349(2):261-9. [PubMed: 21087601]  [MGI Ref ID J:168016]

Riddle RC; Leslie JM; Gross TS; Clemens TL. 2011. Hypoxia-inducible Factor-1alpha Protein Negatively Regulates Load-induced Bone Formation. J Biol Chem 286(52):44449-56. [PubMed: 22081627]  [MGI Ref ID J:178824]

Sans MD; Sabbatini ME; Ernst SA; D'Alecy LG; Nishijima I; Williams JA. 2011. Secretin is not necessary for exocrine pancreatic development and growth in mice. Am J Physiol Gastrointest Liver Physiol 301(5):G791-8. [PubMed: 21852360]  [MGI Ref ID J:178016]

Sato A; Yamamoto H; Sakane H; Koyama H; Kikuchi A. 2010. Wnt5a regulates distinct signalling pathways by binding to Frizzled2. EMBO J 29(1):41-54. [PubMed: 19910923]  [MGI Ref ID J:156508]

Schneider FT; Schanzer A; Czupalla CJ; Thom S; Engels K; Schmidt MH; Plate KH; Liebner S. 2010. Sonic hedgehog acts as a negative regulator of {beta}-catenin signaling in the adult tongue epithelium. Am J Pathol 177(1):404-14. [PubMed: 20508033]  [MGI Ref ID J:162106]

Schwab KR; Patterson LT; Hartman HA; Song N; Lang RA; Lin X; Potter SS. 2007. Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development. BMC Biol 5:15. [PubMed: 17425782]  [MGI Ref ID J:121918]

Selvadurai HJ; Mason JO. 2011. Wnt/beta-catenin signalling is active in a highly dynamic pattern during development of the mouse cerebellum. PLoS One 6(8):e23012. [PubMed: 21857982]  [MGI Ref ID J:176501]

Sherwood RI; Maehr R; Mazzoni EO; Melton DA. 2011. Wnt signaling specifies and patterns intestinal endoderm. Mech Dev 128(7-10):387-400. [PubMed: 21854845]  [MGI Ref ID J:178354]

Smith MK; Koch PJ; Reynolds SD. 2012. Direct and indirect roles for beta-catenin in facultative basal progenitor cell differentiation. Am J Physiol Lung Cell Mol Physiol 302(6):L580-94. [PubMed: 22227204]  [MGI Ref ID J:183435]

Solberg N; Machon O; Krauss S. 2008. Effect of canonical Wnt inhibition in the neurogenic cortex, hippocampus, and premigratory dentate gyrus progenitor pool. Dev Dyn 237(7):1799-811. [PubMed: 18521945]  [MGI Ref ID J:137035]

Sparrow DB; Chapman G; Smith AJ; Mattar MZ; Major JA; O'Reilly VC; Saga Y; Zackai EH; Dormans JP; Alman BA; McGregor L; Kageyama R; Kusumi K; Dunwoodie SL. 2012. A mechanism for gene-environment interaction in the etiology of congenital scoliosis. Cell 149(2):295-306. [PubMed: 22484060]  [MGI Ref ID J:186213]

Stenman JM; Rajagopal J; Carroll TJ; Ishibashi M; McMahon J; McMahon AP. 2008. Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature. Science 322(5905):1247-50. [PubMed: 19023080]  [MGI Ref ID J:142352]

Sundararajan S; Wakamiya M; Behringer RR; Rivera-Perez JA. 2012. A fast and sensitive alternative for beta-galactosidase detection in mouse embryos. Development 139(23):4484-90. [PubMed: 23132248]  [MGI Ref ID J:190884]

Suomalainen M; Thesleff I. 2009. Patterns of Wnt pathway activity in the mouse incisor indicate absence of Wnt/beta-catenin signaling in the epithelial stem cells. Dev Dyn 239(1):364-372. [PubMed: 19806668]  [MGI Ref ID J:155223]

Swope D; Li J; Muller EJ; Radice GL. 2012. Analysis of a Jup hypomorphic allele reveals a critical threshold for postnatal viability. Genesis :. [PubMed: 22522917]  [MGI Ref ID J:187805]

Tang M; Luo SX; Tang V; Huang EJ. 2013. Temporal and spatial requirements of Smoothened in ventral midbrain neuronal development. Neural Dev 8:8. [PubMed: 23618354]  [MGI Ref ID J:199133]

Tiozzo C; Carraro G; Al Alam D; Baptista S; Danopoulos S; Li A; Lavarreda-Pearce M; Li C; De Langhe S; Chan B; Borok Z; Bellusci S; Minoo P. 2012. Mesodermal Pten inactivation leads to alveolar capillary dysplasia- like phenotype. J Clin Invest 122(11):3862-72. [PubMed: 23023706]  [MGI Ref ID J:192736]

Tran PV; Talbott GC; Turbe-Doan A; Jacobs DT; Schonfeld MP; Silva LM; Chatterjee A; Prysak M; Allard BA; Beier DR. 2014. Downregulating Hedgehog Signaling Reduces Renal Cystogenic Potential of Mouse Models. J Am Soc Nephrol :. [PubMed: 24700869]  [MGI Ref ID J:213263]

Tsai SY; Sennett R; Rezza A; Clavel C; Grisanti L; Zemla R; Najam S; Rendl M. 2014. Wnt/beta-catenin signaling in dermal condensates is required for hair follicle formation. Dev Biol 385(2):179-88. [PubMed: 24309208]  [MGI Ref ID J:205498]

Ukita K; Hirahara S; Oshima N; Imuta Y; Yoshimoto A; Jang CW; Oginuma M; Saga Y; Behringer RR; Kondoh H; Sasaki H. 2009. Wnt signaling maintains the notochord fate for progenitor cells and supports the posterior extension of the notochord. Mech Dev 126(10):791-803. [PubMed: 19720144]  [MGI Ref ID J:153634]

Valenta T; Gay M; Steiner S; Draganova K; Zemke M; Hoffmans R; Cinelli P; Aguet M; Sommer L; Basler K. 2011. Probing transcription-specific outputs of beta-catenin in vivo. Genes Dev 25(24):2631-43. [PubMed: 22190459]  [MGI Ref ID J:178971]

Voutilainen M; Lindfors PH; Lefebvre S; Ahtiainen L; Fliniaux I; Rysti E; Murtoniemi M; Schneider P; Schmidt-Ullrich R; Mikkola ML. 2012. Ectodysplasin regulates hormone-independent mammary ductal morphogenesis via NF-kappaB. Proc Natl Acad Sci U S A 109(15):5744-9. [PubMed: 22451941]  [MGI Ref ID J:183539]

Welsh IC; Thomsen M; Gludish DW; Alfonso-Parra C; Bai Y; Martin JF; Kurpios NA. 2013. Integration of left-right Pitx2 transcription and Wnt signaling drives asymmetric gut morphogenesis via Daam2. Dev Cell 26(6):629-44. [PubMed: 24091014]  [MGI Ref ID J:204986]

Westenskow P; Piccolo S; Fuhrmann S. 2009. Beta-catenin controls differentiation of the retinal pigment epithelium in the mouse optic cup by regulating Mitf and Otx2 expression. Development 136(15):2505-10. [PubMed: 19553286]  [MGI Ref ID J:152855]

Xie W; Lynch TJ; Liu X; Tyler SR; Yu S; Zhou X; Luo M; Kusner DM; Sun X; Yi Y; Zhang Y; Goodheart MJ; Parekh KR; Wells JM; Xue HH; Pevny LH; Engelhardt JF. 2014. Sox2 modulates Lef-1 expression during airway submucosal gland development. Am J Physiol Lung Cell Mol Physiol 306(7):L645-60. [PubMed: 24487391]  [MGI Ref ID J:210182]

Xu B; Chen C; Chen H; Zheng SG; Bringas P Jr; Xu M; Zhou X; Chen D; Umans L; Zwijsen A; Shi W. 2011. Smad1 and its target gene Wif1 coordinate BMP and Wnt signaling activities to regulate fetal lung development. Development 138(5):925-35. [PubMed: 21270055]  [MGI Ref ID J:169137]

Youssef KK; Lapouge G; Bouvree K; Rorive S; Brohee S; Appelstein O; Larsimont JC; Sukumaran V; Van de Sande B; Pucci D; Dekoninck S; Berthe JV; Aerts S; Salmon I; del Marmol V; Blanpain C. 2012. Adult interfollicular tumour-initiating cells are reprogrammed into an embryonic hair follicle progenitor-like fate during basal cell carcinoma initiation. Nat Cell Biol 14(12):1282-94. [PubMed: 23178882]  [MGI Ref ID J:195242]

Zaghetto AA; Paina S; Mantero S; Platonova N; Peretto P; Bovetti S; Puche A; Piccolo S; Merlo GR. 2007. Activation of the Wnt-beta catenin pathway in a cell population on the surface of the forebrain is essential for the establishment of olfactory axon connections. J Neurosci 27(36):9757-68. [PubMed: 17804636]  [MGI Ref ID J:124891]

Zhang Y; Goss AM; Cohen ED; Kadzik R; Lepore JJ; Muthukumaraswamy K; Yang J; DeMayo FJ; Whitsett JA; Parmacek MS; Morrisey EE. 2008. A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration. Nat Genet 40(7):862-70. [PubMed: 18536717]  [MGI Ref ID J:138407]

Zhao T; Gan Q; Stokes A; Lassiter RN; Wang Y; Chan J; Han JX; Pleasure DE; Epstein JA; Zhou CJ. 2014. beta-catenin regulates Pax3 and Cdx2 for caudal neural tube closure and elongation. Development 141(1):148-57. [PubMed: 24284205]  [MGI Ref ID J:206311]

Zhong Z; Zylstra-Diegel CR; Schumacher CA; Baker JJ; Carpenter AC; Rao S; Yao W; Guan M; Helms JA; Lane NE; Lang RA; Williams BO. 2012. Wntless functions in mature osteoblasts to regulate bone mass. Proc Natl Acad Sci U S A 109(33):E2197-204. [PubMed: 22745162]  [MGI Ref ID J:188416]

Zhu H; Zhao J; Zhou W; Li H; Zhou R; Zhang L; Zhao H; Cao J; Zhu X; Hu H; Ma G; He L; Yao Z; Yao L; Guo X. 2012. Ndrg2 regulates vertebral specification in differentiating somites. Dev Biol 369(2):308-18. [PubMed: 22819676]  [MGI Ref ID J:187603]

von Gise A; Zhou B; Honor LB; Ma Q; Petryk A; Pu WT. 2011. WT1 regulates epicardial epithelial to mesenchymal transition through beta-catenin and retinoic acid signaling pathways. Dev Biol 356(2):421-31. [PubMed: 21663736]  [MGI Ref ID J:175466]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX10

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, these mice may be bred as hemizygotes or homozygotes.
Mating SystemHomozygote x Homozygote         (Female x Male)   25-JUL-09
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $239.00Female or MaleHomozygous for Tg(BAT-lacZ)3Picc  
Price per Pair (US dollars $)Pair Genotype
$478.00Homozygous for Tg(BAT-lacZ)3Picc x Homozygous for Tg(BAT-lacZ)3Picc  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $310.70Female or MaleHomozygous for Tg(BAT-lacZ)3Picc  
Price per Pair (US dollars $)Pair Genotype
$621.40Homozygous for Tg(BAT-lacZ)3Picc x Homozygous for Tg(BAT-lacZ)3Picc  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice
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JAX® Services
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Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
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Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

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General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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