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| These the BAT-GAL transgenic mice (also called β-catenin/TCF/LEF reporter transgenic mice) are a reporter strain that express beta-galactosidase in the presence of activated beta-catenin (mimics the pattern of Wnt signaling). These mice may be useful for identifying mutations that affect the Wnt-signalling pathway, and in the identification of Wnt-responsive cell populations in development and disease. | |||||||||||||||||||
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Description
Strain Information
Type Congenic; Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Homozygote x Homozygote (Female x Male) 25-JUL-09 Species laboratory mouse Generation N6+N1F7 (27-JAN-10)
Generation DefinitionsDonating Investigator Stefano Piccolo, UNIVERSITY OF PADUA Description
Mice homozygous for the transgenic insert are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. These "BAT-GAL" transgenic mice are a reporter strain that express beta-galactosidase in the presence of activated beta-catenin. The transgene expresses the lacZ gene under the control of a regulatory sequence consisting of seven consensus LEF/TCF-binding motifs upstream of the Xenopus siamois gene minimal promoter. Transgenic mice display beta-galactosidase activity beginning at embryonic day 6.0 in the posterior side of the proximal epiblast. Beta-galactosidase expression is detectable in the posterior primitive streak and node at gastrulation, and progresses to the paraxial mesoderm and notochord. Beta-galactosidase activity in developing and adult nervous tissue mimics the pattern of Wnt signaling. When bred to other mutant strains, this reporter strain may be useful for identifying mutations that affect the Wnt-signalling pathway, and in the identification of Wnt-responsive cell populations in development and disease.In 2012, the laboratory of Dr. Glen L Radice (Thomas Jefferson University, Philadelphia) reported that when breeding BAT-GAL transgenic mice with junction plakoglobin mutant mice (Jup; see Stock No. 017575), the BAT-GAL transgene did not segregate randomly with respect to the Jup locus. They concluded that the BAT-GAL transgene is located within several centimorgans (11/201, 5.47% recombination frequency) of the Jup gene (Chr11:100230272-100259077 bp; - strand [NCBI Build 37]). For similar Wnt-signalling beta-galactosidase reporter function with mutant alleles on chromosome 11, they suggest considering TOP-GAL transgenic mice (Stock No. 004623).
Development
A transgenic construct containing the lacZ gene under the control of a promoter consisting of seven consensus LEF-/TCF-binding motifs upstream of the 0.13 kb minimal promoter of the Xenopus siamois gene was injected into fertilized B6D2F2 mouse eggs. Founder animals were bred to CD-1 outbred mice. After this, transgenic mice were bred to C57BL/6J mice for at least five generations prior to sending to The Jackson Laboratory Repository in 2006. Upon arrival, transgenic mice were bred once to C57BL/6J inbred mice (Stock No. 000664), and then the colony has been maintained by breeding transgenic mice together.
Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
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Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Tg(BAT-lacZ)3Picc/Tg(BAT-lacZ)3Picc
involves: C57BL/6 * DBA/2
- normal phenotype
- no abnormal phenotype detected
- homozygotes are viable, fertile and display no gross physical or behavioral abnormalities (MGI Ref ID J:82727)
- transgene gives a read-out of beta-catenin activity by expression of beta-galactosidase; expression is initially detectable at E6 in posterior side of proximal epiblast and is observed in the posterior primitive streak and node at gastrulation, progressing to the paraxial mesoderm and notochord (MGI Ref ID J:82727)
- expression in developing and adult tissues mimics the pattern of Wnt signaling (MGI Ref ID J:82727)
This mouse can be used to support research in many areas including:
Cell Biology Research
Signal Transduction
Developmental Biology Research
Cell Motility Defects
Defects in Cell Adhesion Molecules
Defects in Extracellular Matrix Molecules
Growth Defects
Internal/Organ Defects
Limb Patterning Defects
Mesodermal Defects
Neural Crest Defects
Neurodevelopmental Defects
Skeletal Defects
Neurobiology Research
lacZ expression in neural tissue
Neurodevelopmental Defects
Research Tools
lacZ Expression
Developmental Biology Research
Genetics Research
Tissue/Cell Markers
Tissue/Cell Markers: neurons
Neurobiology Research
cell marker
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Tg(BAT-lacZ)3Picc | ||
|---|---|---|---|
| Allele Name | transgene insertion 3, Stefano Piccolo | ||
| Allele Type | Transgenic (Reporter) | ||
| Common Name(s) | BAT-gal; BAT::gal; BATnlacZ; BATGAL; | ||
| Strain of Origin | (C57BL/6 x DBA/2)F2 | ||
| Site of Expression | beta-galactosidase activity in developing and adult nervous tissue mimics the pattern of Wnt signaling | ||
| Expressed Gene | lacZ, beta-galactosidase, E. coli | ||
| Promoter | siamois, siamois gene minimal promoter, Xenopus, | ||
| General Note | This is one of three "BAT-gal" transgenic lines generated, which the authors state exhibitied "qualitatively identical expression patterns, although quantitative differences could be observed." | ||
| Molecular Note | Mice with this transgene express nuclear beta-galactosidase under control of the beta-catenin-activated transgene (BAT) promoter. This promoter consists of a DNA fragment extending 0.13 kb upstream from the translation start site of the novel protein containing homeodomain (siamois) gene of Xenopus laevis, which contains the (beta-catenin non-responsive) minimal promoter of this natively beta-catenin activated gene, downstream of seven synthetic lymphoid enhancer factor/T-cell factor- (LEF/TCF-) binding sites that effectively restore the promoter's beta-catenin responsiveness. The transgene does not segregate randomly with respect to the Jup locus indicating that the transgene insertion site is genetically linked to Jup. [MGI Ref ID J:82727] | ||
| Gene Symbol and Name | Tg(BAT-lacZ)3Picc, transgene insertion 3, Stefano Piccolo | ||
| Chromosome | 11 | ||
| Gene Common Name(s) | BAT-gal; BATnlacZ; BATGAL; beta-catenin activated transgene driving expression of nuclear beta-galactosidase reporter; | ||
Genotyping
Genotyping Information
Genotyping Protocols
Generic LacZ Melt Curve Analysis, Melt Curve Analysis
Generic LacZ QPCR, QPCR
Generic LacZ, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Maretto S; Cordenonsi M; Dupont S; Braghetta P; Broccoli V; Hassan AB; Volpin D; Bressan GM; Piccolo S. 2003. Mapping Wnt/beta-catenin signaling during mouse development and in colorectal tumors. Proc Natl Acad Sci U S A 100(6):3299-304. [PubMed: 12626757] [MGI Ref ID J:82727]
Additional References
Tg(BAT-lacZ)3Picc relatedAl Alam D; Green M; Tabatabai Irani R; Parsa S; Danopoulos S; Sala FG; Branch J; El Agha E; Tiozzo C; Voswinckel R; Jesudason EC; Warburton D; Bellusci S. 2011. Contrasting expression of canonical Wnt signaling reporters TOPGAL, BATGAL and Axin2(LacZ) during murine lung development and repair. PLoS One 6(8):e23139. [PubMed: 21858009] [MGI Ref ID J:176498]
Andoniadou CL; Signore M; Young RM; Gaston-Massuet C; Wilson SW; Fuchs E; Martinez-Barbera JP. 2011. HESX1- and TCF3-mediated repression of Wnt/beta-catenin targets is required for normal development of the anterior forebrain. Development 138(22):4931-42. [PubMed: 22007134] [MGI Ref ID J:181005]
Aulehla A; Wiegraebe W; Baubet V; Wahl MB; Deng C; Taketo M; Lewandoski M; Pourquie O. 2008. A beta-catenin gradient links the clock and wavefront systems in mouse embryo segmentation. Nat Cell Biol 10(2):186-93. [PubMed: 18157121] [MGI Ref ID J:132361]
Beites CL; Hollenbeck PL; Kim J; Lovell-Badge R; Lander AD; Calof AL. 2009. Follistatin modulates a BMP autoregulatory loop to control the size and patterning of sensory domains in the developing tongue. Development 136(13):2187-97. [PubMed: 19474151] [MGI Ref ID J:149988]
Berbari NF; Kin NW; Sharma N; Michaud EJ; Kesterson RA; Yoder BK. 2011. Mutations in Traf3ip1 reveal defects in ciliogenesis, embryonic development, and altered cell size regulation. Dev Biol 360(1):66-76. [PubMed: 21945076] [MGI Ref ID J:178483]
Bloomekatz J; Grego-Bessa J; Migeotte I; Anderson KV. 2012. Pten regulates collective cell migration during specification of the anterior-posterior axis of the mouse embryo. Dev Biol 364(2):192-201. [PubMed: 22342906] [MGI Ref ID J:183946]
Bluske KK; Kawakami Y; Koyano-Nakagawa N; Nakagawa Y. 2009. Differential activity of Wnt/beta-catenin signaling in the embryonic mouse thalamus. Dev Dyn 238(12):3297-3309. [PubMed: 19924825] [MGI Ref ID J:154363]
Bluske KK; Vue TY; Kawakami Y; Taketo MM; Yoshikawa K; Johnson JE; Nakagawa Y. 2012. beta-Catenin signaling specifies progenitor cell identity in parallel with Shh signaling in the developing mammalian thalamus. Development 139(15):2692-702. [PubMed: 22745311] [MGI Ref ID J:185651]
Borello U; Cobos I; Long JE; McWhirter JR; Murre C; Rubenstein JL. 2008. FGF15 promotes neurogenesis and opposes FGF8 function during neocortical development. Neural Dev 3:17. [PubMed: 18625063] [MGI Ref ID J:160580]
Boulday G; Rudini N; Maddaluno L; Blecon A; Arnould M; Gaudric A; Chapon F; Adams RH; Dejana E; Tournier-Lasserve E. 2011. Developmental timing of CCM2 loss influences cerebral cavernous malformations in mice. J Exp Med 208(9):1835-47. [PubMed: 21859843] [MGI Ref ID J:177584]
Bridgewater D; Cox B; Cain J; Lau A; Athaide V; Gill PS; Kuure S; Sainio K; Rosenblum ND. 2008. Canonical WNT/beta-catenin signaling is required for ureteric branching. Dev Biol 317(1):83-94. [PubMed: 18358465] [MGI Ref ID J:136068]
Buchert M; Athineos D; Abud HE; Burke ZD; Faux MC; Samuel MS; Jarnicki AG; Winbanks CE; Newton IP; Meniel VS; Suzuki H; Stacker SA; Nathke IS; Tosh D; Huelsken J; Clarke AR; Heath JK; Sansom OJ; Ernst M. 2010. Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo. PLoS Genet 6(1):e1000816. [PubMed: 20084116] [MGI Ref ID J:156864]
Burn SF; Webb A; Berry RL; Davies JA; Ferrer-Vaquer A; Hadjantonakis AK; Hastie ND; Hohenstein P. 2011. Calcium/NFAT signalling promotes early nephrogenesis. Dev Biol 352(2):288-98. [PubMed: 21295565] [MGI Ref ID J:171469]
Chen F; Cao Y; Qian J; Shao F; Niederreither K; Cardoso WV. 2010. A retinoic acid-dependent network in the foregut controls formation of the mouse lung primordium. J Clin Invest 120(6):2040-8. [PubMed: 20484817] [MGI Ref ID J:161637]
Chilov D; Sinjushina N; Saarimaki-Vire J; Taketo MM; Partanen J. 2010. beta-Catenin regulates intercellular signalling networks and cell-type specific transcription in the developing mouse midbrain-rhombomere 1 region. PLoS One 5(6):e10881. [PubMed: 20532162] [MGI Ref ID J:161813]
Cohen ED; Ihida-Stansbury K; Lu MM; Panettieri RA; Jones PL; Morrisey EE. 2009. Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway. J Clin Invest 119(9):2538-49. [PubMed: 19690384] [MGI Ref ID J:152705]
Cohen ED; Miller MF; Wang Z; Moon RT; Morrisey EE. 2012. Wnt5a and Wnt11 are essential for second heart field progenitor development. Development 139(11):1931-40. [PubMed: 22569553] [MGI Ref ID J:184511]
Cohen ED; Wang Z; Lepore JJ; Lu MM; Taketo MM; Epstein DJ; Morrisey EE. 2007. Wnt/beta-catenin signaling promotes expansion of Isl-1-positive cardiac progenitor cells through regulation of FGF signaling. J Clin Invest 117(7):1794-804. [PubMed: 17607356] [MGI Ref ID J:124189]
Collette NM; Genetos DC; Murugesh D; Harland RM; Loots GG. 2010. Genetic evidence that SOST inhibits WNT signaling in the limb. Dev Biol 342(2):169-79. [PubMed: 20359476] [MGI Ref ID J:161416]
Corbit KC; Shyer AE; Dowdle WE; Gaulden J; Singla V; Reiter JF. 2008. Kif3a constrains beta-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms. Nat Cell Biol 10(1):70-6. [PubMed: 18084282] [MGI Ref ID J:132369]
Cui Y; Niziolek PJ; Macdonald BT; Zylstra CR; Alenina N; Robinson DR; Zhong Z; Matthes S; Jacobsen CM; Conlon RA; Brommage R; Liu Q; Mseeh F; Powell DR; Yang QM; Zambrowicz B; Gerrits H; Gossen JA; He X; Bader M; Williams BO; Warman ML; Robling AG. 2011. Lrp5 functions in bone to regulate bone mass. Nat Med 17(6):684-91. [PubMed: 21602802] [MGI Ref ID J:172746]
Davis RB; Curtis CD; Griffin CT. 2013. BRG1 promotes COUP-TFII expression and venous specification during embryonic vascular development. Development 140(6):1272-81. [PubMed: 23406903] [MGI Ref ID J:194470]
Demireva EY; Shapiro LS; Jessell TM; Zampieri N. 2011. Motor neuron position and topographic order imposed by beta- and gamma-catenin activities. Cell 147(3):641-52. [PubMed: 22036570] [MGI Ref ID J:178688]
Du J; Takeuchi H; Leonhard-Melief C; Shroyer KR; Dlugosz M; Haltiwanger RS; Holdener BC. 2010. O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. Dev Biol 346(1):25-38. [PubMed: 20637190] [MGI Ref ID J:165751]
Etheridge SL; Ray S; Li S; Hamblet NS; Lijam N; Tsang M; Greer J; Kardos N; Wang J; Sussman DJ; Chen P; Wynshaw-Boris A. 2008. Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development. PLoS Genet 4(11):e1000259. [PubMed: 19008950] [MGI Ref ID J:142392]
Faedo A; Tomassy GS; Ruan Y; Teichmann H; Krauss S; Pleasure SJ; Tsai SY; Tsai MJ; Studer M; Rubenstein JL. 2008. COUP-TFI coordinates cortical patterning, neurogenesis, and laminar fate and modulates MAPK/ERK, AKT, and beta-catenin signaling. Cereb Cortex 18(9):2117-31. [PubMed: 18165280] [MGI Ref ID J:146820]
Fancy SP; Baranzini SE; Zhao C; Yuk DI; Irvine KA; Kaing S; Sanai N; Franklin RJ; Rowitch DH. 2009. Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS. Genes Dev 23(13):1571-85. [PubMed: 19515974] [MGI Ref ID J:150044]
Ferretti E; Li B; Zewdu R; Wells V; Hebert JM; Karner C; Anderson MJ; Williams T; Dixon J; Dixon MJ; Depew MJ; Selleri L. 2011. A conserved Pbx-Wnt-p63-Irf6 regulatory module controls face morphogenesis by promoting epithelial apoptosis. Dev Cell 21(4):627-41. [PubMed: 21982646] [MGI Ref ID J:178316]
Fossat N; Jones V; Khoo PL; Bogani D; Hardy A; Steiner K; Mukhopadhyay M; Westphal H; Nolan PM; Arkell R; Tam PP. 2011. Stringent requirement of a proper level of canonical WNT signalling activity for head formation in mouse embryo. Development 138(4):667-76. [PubMed: 21228006] [MGI Ref ID J:170646]
Fotaki V; Price DJ; Mason JO. 2011. Wnt/beta-catenin signaling is disrupted in the extra-toes (Gli3(Xt/Xt) ) mutant from early stages of forebrain development, concomitant with anterior neural plate patterning defects. J Comp Neurol 519(9):1640-57. [PubMed: 21452227] [MGI Ref ID J:174727]
Fujimura N; Taketo MM; Mori M; Korinek V; Kozmik Z. 2009. Spatial and temporal regulation of Wnt/beta-catenin signaling is essential for development of the retinal pigment epithelium. Dev Biol 334(1):31-45. [PubMed: 19596317] [MGI Ref ID J:153566]
Gaillard D; Barlow LA. 2011. Taste bud cells of adult mice are responsive to Wnt/beta-catenin signaling: Implications for the renewal of mature taste cells. Genesis 49(4):295-306. [PubMed: 21328519] [MGI Ref ID J:171517]
Gaston-Massuet C; Andoniadou CL; Signore M; Jayakody SA; Charolidi N; Kyeyune R; Vernay B; Jacques TS; Taketo MM; Le Tissier P; Dattani MT; Martinez-Barbera JP. 2011. From the Cover: Increased Wingless (Wnt) signaling in pituitary progenitor/stem cells gives rise to pituitary tumors in mice and humans. Proc Natl Acad Sci U S A 108(28):11482-7. [PubMed: 21636786] [MGI Ref ID J:174144]
Goss AM; Tian Y; Cheng L; Yang J; Zhou D; Cohen ED; Morrisey EE. 2011. Wnt2 signaling is necessary and sufficient to activate the airway smooth muscle program in the lung by regulating myocardin/Mrtf-B and Fgf10 expression. Dev Biol 356(2):541-52. [PubMed: 21704027] [MGI Ref ID J:175454]
Goss AM; Tian Y; Tsukiyama T; Cohen ED; Zhou D; Lu MM; Yamaguchi TP; Morrisey EE. 2009. Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut. Dev Cell 17(2):290-8. [PubMed: 19686689] [MGI Ref ID J:153098]
Goux D; Coudert JD; Maurice D; Scarpellino L; Jeannet G; Piccolo S; Weston K; Huelsken J; Held W. 2005. Cooperating pre-T-cell receptor and TCF-1-dependent signals ensure thymocyte survival. Blood 106(5):1726-33. [PubMed: 15890681] [MGI Ref ID J:118496]
Griffin CT; Curtis CD; Davis RB; Muthukumar V; Magnuson T. 2011. The chromatin-remodeling enzyme BRG1 modulates vascular Wnt signaling at two levels. Proc Natl Acad Sci U S A 108(6):2282-7. [PubMed: 21262838] [MGI Ref ID J:169096]
Grimsley-Myers CM; Sipe CW; Wu DK; Lu X. 2012. Redundant functions of Rac GTPases in inner ear morphogenesis. Dev Biol 362(2):172-86. [PubMed: 22182523] [MGI Ref ID J:180774]
Hammerschmidt B; Schlake T. 2007. Localization of Shh expression by Wnt and Eda affects axial polarity and shape of hairs. Dev Biol 305(1):246-61. [PubMed: 17376426] [MGI Ref ID J:121316]
He F; Xiong W; Wang Y; Li L; Liu C; Yamagami T; Taketo MM; Zhou C; Chen Y. 2011. Epithelial Wnt/beta-catenin signaling regulates palatal shelf fusion through regulation of Tgfbeta3 expression. Dev Biol 350(2):511-9. [PubMed: 21185284] [MGI Ref ID J:170579]
Hierholzer A; Kemler R. 2009. beta-catenin-mediated signaling and cell adhesion in postgastrulation mouse embryos. Dev Dyn 239(1):191-199. [PubMed: 19705445] [MGI Ref ID J:155247]
Horner VL; Caspary T. 2011. Disrupted dorsal neural tube BMP signaling in the cilia mutant Arl13b hnn stems from abnormal Shh signaling. Dev Biol 355(1):43-54. [PubMed: 21539826] [MGI Ref ID J:173637]
Ivaniutsin U; Chen Y; Mason JO; Price DJ; Pratt T. 2009. Adenomatous polyposis coli is required for early events in the normal growth and differentiation of the developing cerebral cortex. Neural Dev 4:3. [PubMed: 19149881] [MGI Ref ID J:160733]
Jen YH; Musacchio M; Lander AD. 2009. Glypican-1 controls brain size through regulation of fibroblast growth factor signaling in early neurogenesis. Neural Dev 4:33. [PubMed: 19732411] [MGI Ref ID J:159598]
Karalay O; Doberauer K; Vadodaria KC; Knobloch M; Berti L; Miquelajauregui A; Schwark M; Jagasia R; Taketo MM; Tarabykin V; Lie DC; Jessberger S. 2011. Prospero-related homeobox 1 gene (Prox1) is regulated by canonical Wnt signaling and has a stage-specific role in adult hippocampal neurogenesis. Proc Natl Acad Sci U S A 108(14):5807-12. [PubMed: 21436036] [MGI Ref ID J:171216]
Kawakami Y; Marti M; Kawakami H; Itou J; Quach T; Johnson A; Sahara S; O'Leary DD; Nakagawa Y; Lewandoski M; Pfaff S; Evans SM; Izpisua Belmonte JC. 2011. Islet1-mediated activation of the beta-catenin pathway is necessary for hindlimb initiation in mice. Development 138(20):4465-73. [PubMed: 21937598] [MGI Ref ID J:178771]
Kemler R; Hierholzer A; Kanzler B; Kuppig S; Hansen K; Taketo MM; de Vries WN; Knowles BB; Solter D. 2004. Stabilization of {beta}-catenin in the mouse zygote leads to premature epithelial-mesenchymal transition in the epiblast. Development 131(23):5817-5824. [PubMed: 15525667] [MGI Ref ID J:94395]
Kreslova J; Machon O; Ruzickova J; Lachova J; Wawrousek EF; Kemler R; Krauss S; Piatigorsky J; Kozmik Z. 2007. Abnormal lens morphogenesis and ectopic lens formation in the absence of beta-catenin function. Genesis 45(4):157-68. [PubMed: 17410548] [MGI Ref ID J:121794]
Kumamoto N; Gu Y; Wang J; Janoschka S; Takemaru K; Levine J; Ge S. 2012. A role for primary cilia in glutamatergic synaptic integration of adult-born neurons. Nat Neurosci 15(3):399-405, S1. [PubMed: 22306608] [MGI Ref ID J:182293]
Lancaster MA; Gopal DJ; Kim J; Saleem SN; Silhavy JL; Louie CM; Thacker BE; Williams Y; Zaki MS; Gleeson JG. 2011. Defective Wnt-dependent cerebellar midline fusion in a mouse model of Joubert syndrome. Nat Med 17(6):726-31. [PubMed: 21623382] [MGI Ref ID J:172420]
Lancaster MA; Schroth J; Gleeson JG. 2011. Subcellular spatial regulation of canonical Wnt signalling at the primary cilium. Nat Cell Biol 13(6):700-7. [PubMed: 21602792] [MGI Ref ID J:174986]
Lang J; Maeda Y; Bannerman P; Xu J; Horiuchi M; Pleasure D; Guo F. 2013. Adenomatous polyposis coli regulates oligodendroglial development. J Neurosci 33(7):3113-30. [PubMed: 23407966] [MGI Ref ID J:194259]
Larkins CE; Long AB; Caspary T. 2012. Defective Nodal and Cerl2 expression in the Arl13b(hnn) mutant node underlie its heterotaxia. Dev Biol 367(1):15-24. [PubMed: 22554696] [MGI Ref ID J:185804]
Lewis SL; Khoo PL; De Young RA; Steiner K; Wilcock C; Mukhopadhyay M; Westphal H; Jamieson RV; Robb L; Tam PP. 2008. Dkk1 and Wnt3 interact to control head morphogenesis in the mouse. Development 135(10):1791-801. [PubMed: 18403408] [MGI Ref ID J:134688]
Li B; Rheaume C; Teng A; Bilanchone V; Munguia JE; Hu M; Jessen S; Piccolo S; Waterman ML; Dai X. 2007. Developmental phenotypes and reduced Wnt signaling in mice deficient for pygopus 2. Genesis 45(5):318-25. [PubMed: 17458864] [MGI Ref ID J:121776]
Li X; Shan J; Chang W; Kim I; Bao J; Lee HJ; Zhang X; Samuel VT; Shulman GI; Liu D; Zheng JJ; Wu D. 2012. Chemical and genetic evidence for the involvement of Wnt antagonist Dickkopf2 in regulation of glucose metabolism. Proc Natl Acad Sci U S A 109(28):11402-7. [PubMed: 22733757] [MGI Ref ID J:186402]
Liebner S; Corada M; Bangsow T; Babbage J; Taddei A; Czupalla CJ; Reis M; Felici A; Wolburg H; Fruttiger M; Taketo MM; von Melchner H; Plate KH; Gerhardt H; Dejana E. 2008. Wnt/beta-catenin signaling controls development of the blood-brain barrier. J Cell Biol 183(3):409-17. [PubMed: 18955553] [MGI Ref ID J:141415]
Lin C; Fisher AV; Yin Y; Maruyama T; Veith GM; Dhandha M; Huang GJ; Hsu W; Ma L. 2011. The inductive role of Wnt-beta-Catenin signaling in the formation of oral apparatus. Dev Biol 356(1):40-50. [PubMed: 21600200] [MGI Ref ID J:175262]
Lin SL; Li B; Rao S; Yeo EJ; Hudson TE; Nowlin BT; Pei H; Chen L; Zheng JJ; Carroll TJ; Pollard JW; McMahon AP; Lang RA; Duffield JS. 2010. Macrophage Wnt7b is critical for kidney repair and regeneration. Proc Natl Acad Sci U S A 107(9):4194-9. [PubMed: 20160075] [MGI Ref ID J:158579]
Lindvall C; Zylstra CR; Evans N; West RA; Dykema K; Furge KA; Williams BO. 2009. The Wnt co-receptor Lrp6 is required for normal mouse mammary gland development. PLoS One 4(6):e5813. [PubMed: 19503830] [MGI Ref ID J:150203]
Liu F; Chu EY; Watt B; Zhang Y; Gallant NM; Andl T; Yang SH; Lu MM; Piccolo S; Schmidt-Ullrich R; Taketo MM; Morrisey EE; Atit R; Dlugosz AA; Millar SE. 2008. Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis. Dev Biol 313(1):210-24. [PubMed: 18022614] [MGI Ref ID J:130228]
Liu W; Lagutin O; Swindell E; Jamrich M; Oliver G. 2010. Neuroretina specification in mouse embryos requires Six3-mediated suppression of Wnt8b in the anterior neural plate. J Clin Invest 120(10):3568-77. [PubMed: 20890044] [MGI Ref ID J:165328]
Lorenz K; Grashoff C; Torka R; Sakai T; Langbein L; Bloch W; Aumailley M; Fassler R. 2007. Integrin-linked kinase is required for epidermal and hair follicle morphogenesis. J Cell Biol 177(3):501-13. [PubMed: 17485490] [MGI Ref ID J:134724]
Love D; Li FQ; Burke MC; Cyge B; Ohmitsu M; Cabello J; Larson JE; Brody SL; Cohen JC; Takemaru K. 2010. Altered lung morphogenesis, epithelial cell differentiation and mechanics in mice deficient in the Wnt/beta-catenin antagonist Chibby. PLoS One 5(10):e13600. [PubMed: 21049041] [MGI Ref ID J:166685]
Lu P; Yu Y; Perdue Y; Werb Z. 2008. The apical ectodermal ridge is a timer for generating distal limb progenitors. Development 135(8):1395-405. [PubMed: 18359901] [MGI Ref ID J:136057]
Ma S; Kwon HJ; Johng H; Zang K; Huang Z. 2013. Radial glial neural progenitors regulate nascent brain vascular network stabilization via inhibition of Wnt signaling. PLoS Biol 11(1):e1001469. [PubMed: 23349620] [MGI Ref ID J:194480]
Machon O; Backman M; Machonova O; Kozmik Z; Vacik T; Andersen L; Krauss S. 2007. A dynamic gradient of Wnt signaling controls initiation of neurogenesis in the mammalian cortex and cellular specification in the hippocampus. Dev Biol 311(1):223-37. [PubMed: 17916349] [MGI Ref ID J:126323]
Machon O; Kreslova J; Ruzickova J; Vacik T; Klimova L; Fujimura N; Lachova J; Kozmik Z. 2010. Lens morphogenesis is dependent on Pax6-mediated inhibition of the canonical Wnt/beta-catenin signaling in the lens surface ectoderm. Genesis 48(2):86-95. [PubMed: 20027618] [MGI Ref ID J:158407]
Maes C; Goossens S; Bartunkova S; Drogat B; Coenegrachts L; Stockmans I; Moermans K; Nyabi O; Haigh K; Naessens M; Haenebalcke L; Tuckermann JP; Tjwa M; Carmeliet P; Mandic V; David JP; Behrens A; Nagy A; Carmeliet G; Haigh JJ. 2010. Increased skeletal VEGF enhances beta-catenin activity and results in excessively ossified bones. EMBO J 29(2):424-41. [PubMed: 20010698] [MGI Ref ID J:156474]
Manicassamy S; Reizis B; Ravindran R; Nakaya H; Salazar-Gonzalez RM; Wang YC; Pulendran B. 2010. Activation of beta-catenin in dendritic cells regulates immunity versus tolerance in the intestine. Science 329(5993):849-53. [PubMed: 20705860] [MGI Ref ID J:163676]
Mao J; McKean DM; Warrier S; Corbin JG; Niswander L; Zohn IE. 2010. The iron exporter ferroportin 1 is essential for development of the mouse embryo, forebrain patterning and neural tube closure. Development 137(18):3079-88. [PubMed: 20702562] [MGI Ref ID J:164587]
Migeotte I; Omelchenko T; Hall A; Anderson KV. 2010. Rac1-dependent collective cell migration is required for specification of the anterior-posterior body axis of the mouse. PLoS Biol 8(8):e1000442. [PubMed: 20689803] [MGI Ref ID J:166095]
Munne PM; Tummers M; Jarvinen E; Thesleff I; Jernvall J. 2009. Tinkering with the inductive mesenchyme: Sostdc1 uncovers the role of dental mesenchyme in limiting tooth induction. Development 136(3):393-402. [PubMed: 19141669] [MGI Ref ID J:144193]
Mutch CA; Funatsu N; Monuki ES; Chenn A. 2009. Beta-catenin signaling levels in progenitors influence the laminar cell fates of projection neurons. J Neurosci 29(43):13710-9. [PubMed: 19864583] [MGI Ref ID J:158308]
Narhi K; Jarvinen E; Birchmeier W; Taketo MM; Mikkola ML; Thesleff I. 2008. Sustained epithelial {beta}-catenin activity induces precocious hair development but disrupts hair follicle down-growth and hair shaft formation. Development 135(6):1019-28. [PubMed: 18256193] [MGI Ref ID J:131961]
Narhi K; Tummers M; Ahtiainen L; Itoh N; Thesleff I; Mikkola ML. 2012. Sostdc1 defines the size and number of skin appendage placodes. Dev Biol 364(2):149-61. [PubMed: 22509524] [MGI Ref ID J:183911]
Nava P; Koch S; Laukoetter MG; Lee WY; Kolegraff K; Capaldo CT; Beeman N; Addis C; Gerner-Smidt K; Neumaier I; Skerra A; Li L; Parkos CA; Nusrat A. 2010. Interferon-gamma regulates intestinal epithelial homeostasis through converging beta-catenin signaling pathways. Immunity 32(3):392-402. [PubMed: 20303298] [MGI Ref ID J:158902]
Norrmen C; Ivanov KI; Cheng J; Zangger N; Delorenzi M; Jaquet M; Miura N; Puolakkainen P; Horsley V; Hu J; Augustin HG; Yla-Herttuala S; Alitalo K; Petrova TV. 2009. FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1. J Cell Biol 185(3):439-57. [PubMed: 19398761] [MGI Ref ID J:149138]
Ohazama A; Johnson EB; Ota MS; Choi HJ; Porntaveetus T; Oommen S; Itoh N; Eto K; Gritli-Linde A; Herz J; Sharpe PT. 2008. Lrp4 modulates extracellular integration of cell signaling pathways in development. PLoS ONE 3(12):e4092. [PubMed: 19116665] [MGI Ref ID J:144348]
Ola R; Jakobson M; Kvist J; Perala N; Kuure S; Braunewell KH; Bridgewater D; Rosenblum ND; Chilov D; Immonen T; Sainio K; Sariola H. 2011. The GDNF target Vsnl1 marks the ureteric tip. J Am Soc Nephrol 22(2):274-84. [PubMed: 21289216] [MGI Ref ID J:191040]
Osorio KM; Lilja KC; Tumbar T. 2011. Runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartments. J Cell Biol 193(1):235-50. [PubMed: 21464233] [MGI Ref ID J:171374]
Pereira PN; Dobreva MP; Maas E; Cornelis FM; Moya IM; Umans L; Verfaillie CM; Camus A; de Sousa Lopes SM; Huylebroeck D; Zwijsen A. 2012. Antagonism of Nodal signaling by BMP/Smad5 prevents ectopic primitive streak formation in the mouse amnion. Development 139(18):3343-54. [PubMed: 22912414] [MGI Ref ID J:187710]
Phng LK; Potente M; Leslie JD; Babbage J; Nyqvist D; Lobov I; Ondr JK; Rao S; Lang RA; Thurston G; Gerhardt H. 2009. Nrarp coordinates endothelial Notch and Wnt signaling to control vessel density in angiogenesis. Dev Cell 16(1):70-82. [PubMed: 19154719] [MGI Ref ID J:144980]
Porntaveetus T; Ohazama A; Choi HY; Herz J; Sharpe PT. 2012. Wnt signaling in the murine diastema. Eur J Orthod 34(4):518-24. [PubMed: 21531785] [MGI Ref ID J:186534]
Qian D; Jones C; Rzadzinska A; Mark S; Zhang X; Steel KP; Dai X; Chen P. 2007. Wnt5a functions in planar cell polarity regulation in mice. Dev Biol 306(1):121-33. [PubMed: 17433286] [MGI Ref ID J:122585]
Reid BS; Yang H; Melvin VS; Taketo MM; Williams T. 2011. Ectodermal Wnt/beta-catenin signaling shapes the mouse face. Dev Biol 349(2):261-9. [PubMed: 21087601] [MGI Ref ID J:168016]
Riddle RC; Leslie JM; Gross TS; Clemens TL. 2011. Hypoxia-inducible Factor-1alpha Protein Negatively Regulates Load-induced Bone Formation. J Biol Chem 286(52):44449-56. [PubMed: 22081627] [MGI Ref ID J:178824]
Sans MD; Sabbatini ME; Ernst SA; D'Alecy LG; Nishijima I; Williams JA. 2011. Secretin is not necessary for exocrine pancreatic development and growth in mice. Am J Physiol Gastrointest Liver Physiol 301(5):G791-8. [PubMed: 21852360] [MGI Ref ID J:178016]
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Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX11
Colony Maintenance
Breeding & Husbandry When maintaining a live colony, these mice may be bred as hemizygotes or homozygotes. Mating System Homozygote x Homozygote (Female x Male) 25-JUL-09 Diet Information LabDiet® 5K52/5K67
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $232.00 Female or Male Homozygous for Tg(BAT-lacZ)3Picc
Price per Pair (US dollars $) Pair Genotype $464.00 Homozygous for Tg(BAT-lacZ)3Picc x Homozygous for Tg(BAT-lacZ)3Picc Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
| Pricing for International shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $301.60 Female or Male Homozygous for Tg(BAT-lacZ)3Picc
Price per Pair (US dollars $) Pair Genotype $603.20 Homozygous for Tg(BAT-lacZ)3Picc x Homozygous for Tg(BAT-lacZ)3Picc Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
|
|
|
Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
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See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
JAX® Mice
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Terms of Use
General Terms and Conditions
For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.
Contact information
General inquiries regarding Terms of UseContracts Administration
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
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In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
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The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.