Strain Name:

NOD.Cg-Il10tm1Cgn Casp1tm1Sesh Casp4del/LtJ

Stock Number:


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Common Names: NOD.IL10,Casp1;    


The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names NOD.Cg-Il10tm1Cgn Casp1tm1Sesh/LtJ    (Changed: 24-APR-13 )
Type Deletion;
Additional information on Mice with Chromosomal Aberrations.
Type Congenic; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
Background Strain NOD/ShiLt
Donor Strain 129
H2 Haplotypeg7
Generation Definitions
Donating InvestigatorDr. Edward Leiter,   The Jackson Laboratory

albino, pink-eyed
Related Genotype: A/? Tyrc/Tyrc

Mice homozygous for the Il10 and Casp1 targeted mutations are viable and fertile when housed under SPF conditions. NOD/Lt mice deficient for both of these genes develop type 1 diabetes at a rate equivalent to the parental strains. The Il10 targeted mutation also renders this NOD/Lt stock susceptible to colitis (although not as severe as other strains of Il10 deficient mice) when maintained under standard housing conditions.

For details related to the construction of each allele, please refer to the entries for strains 004947 and 004266. NOD.Il10 homozygous mice were crossed to NOD.Casp1 homozygous mice prior to making homozygous for both alleles. In 2006, the T1DR received double homozygous mice at generation F16.

Control Information

   None Available
  Considerations for Choosing Controls

Related Strains

Strains carrying   Casp1tm1Sesh allele
004947   NOD.129S2(B6)-Casp1tm1Sesh Casp4del/LtJ
View Strains carrying   Casp1tm1Sesh     (1 strain)

Strains carrying   Casp4del allele
026021   B6;129-Casp4del Panx1tm1Vshe/J
004947   NOD.129S2(B6)-Casp1tm1Sesh Casp4del/LtJ
View Strains carrying   Casp4del     (2 strains)

View Strains carrying   Il10tm1Cgn     (10 strains)

Strains carrying other alleles of Casp1
016621   B6N.129S2-Casp1tm1Flv/J
View Strains carrying other alleles of Casp1     (1 strain)

Strains carrying other alleles of Casp4
024698   B6.129S4(D2)-Casp4tm1Yuan/J
View Strains carrying other alleles of Casp4     (1 strain)

Strains carrying other alleles of Il10
014530   B6(Cg)-Il10tm1.1Karp/J
008379   B6.129S6-Il10tm1Flv/J
005973   C3Bir.129P2(B6)-Il10C3Bir/LtJ
View Strains carrying other alleles of Il10     (3 strains)


Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Graft-Versus-Host Disease, Susceptibility To; GVHDS   (IL10)
Human Immunodeficiency Virus Type 1, Susceptibility to   (IL10)
Rheumatoid Arthritis; RA   (IL10)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Cancer Research
Growth Factors/Receptors/Cytokines

Diabetes and Obesity Research
Type 1 Diabetes (IDDM)
      Congenics with mutations affecting cytokine production by autoreactive T cells
Type 1 Diabetes (IDDM) Analysis Strains
      NOD Congenics with Mutations Affecting Cytokine Production by Autoreactive T Cells

Immunology, Inflammation and Autoimmunity Research
Growth Factors/Receptors/Cytokines
      control strain

Internal/Organ Research
Gastrointestinal Defects

Casp1tm1Sesh related

Diabetes and Obesity Research
Type 1 Diabetes (IDDM)

Immunology, Inflammation and Autoimmunity Research
      B cell defects

Research Tools
Diabetes and Obesity Research

Il10tm1Cgn related

Cancer Research
Growth Factors/Receptors/Cytokines

Hematological Research
Anemia, Iron Deficiency and Transport Defects
Immunological Defects

Immunology, Inflammation and Autoimmunity Research
Growth Factors/Receptors/Cytokines
      Inflammatory bowel disease

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol Casp1tm1Sesh
Allele Name targeted mutation 1, Tara Seshadri
Allele Type Targeted (Null/Knockout)
Common Name(s) Casp1 -; Casp1-/Casp11129mt; Caspase-1-; ICE -; casp-1-;
Mutation Made ByDr. Edward Leiter,   The Jackson Laboratory
Strain of Origin129S2/SvPas
ES Cell Line NameD3
ES Cell Line Strain129S2/SvPas
Gene Symbol and Name Casp1, caspase 1
Chromosome 9
Gene Common Name(s) Caspase-1; ICE; IL1BC; Il1bc; P45; interleukin 1 beta convertase; interleukin 1 beta-converting enzyme;
General Note The ES cells used to generate this allele contain the linked Casp4del truncated allele that fails to produce a functional Casp4. Phenotypes associated with this allele may be affected by the presence of the Caspdel allele. J:193522
Molecular Note A neomycin expression cassette was inserted into exon 6, deleting 31 bp of sequence encoding the region of the active site and rendering the sequence out of frame after the insertion. Northern blot analysis on spleen RNA demonstrated an absence of the normal transcript in homozygous mice, and western blot analysis showed that the protein was not expressed in peritoneal macrophages of homozygous mice. This allele was generated in ES cells that lack protein expression of Casp11 (Casp129mt). [MGI Ref ID J:22964]
Allele Symbol Casp4del
Allele Name deletion
Allele Type Spontaneous
Common Name(s) Casp129;
Strain of Origin129P3/J and 129S1/SvImJ and 129S2/SvPas and 129S6/SvEvTac and 129X1/SvJ
Gene Symbol and Name Casp4, caspase 4, apoptosis-related cysteine peptidase
Chromosome 9
Gene Common Name(s) Casp11; Caspase-11; ICE(rel)II; ICEREL-II; ICH-2; Mih1/TX; TX; capase 11, apoptosis-related cysteine protease; caspase 11, apoptosis-related cysteine peptidase; ich-3;
Molecular Note RT-PCR confirmed that five 129 substrains (129X1/SvJ, 129S1/SvImJ, 129S2/SvPas, 129S6/SvEvTac and 129P3/J) express a transcript that lacks exon 7 (delta110 isoform). Sequencing identified a 5 bp deletion in exon 7 that results in the fusion of exon 6 and8, a frame-shift after proline 304 and a stop codon after 5 aberrant amino acids. This deletion is not present in C57BL/6. Western blot analysis confirmed the absence of protein expression in LPS-primed macrophage. [MGI Ref ID J:193522]
Allele Symbol Il10tm1Cgn
Allele Name targeted mutation 1, University of Cologne
Allele Type Targeted (Null/Knockout)
Common Name(s) IL-10 KO; IL-10-; IL-10KO; IL-10KO; Il10-; Il10tmCgn;
Mutation Made ByDr. Ralf Kuhn,   University of Cologne
Strain of Origin129P2/OlaHsd
ES Cell Line NameE14.1
ES Cell Line Strain129P2/OlaHsd
Gene Symbol and Name Il10, interleukin 10
Chromosome 1
Gene Common Name(s) CSIF; GVHDS; IL-10; IL10A; IL10X; Il-10; TGIF; cytokine synthesis inhibitory factor;
General Note Phenotypic Similarity to Human Syndrome: Idiopathic Inflammatory Bowel Disease (J:15222).
Molecular Note A 500 bp genomic fragment containing codons 5-55 was replaced with a linker containing a termination codon followed by a neomycin cassette. A termination codon was also introduced into exon 3. No IL10 activity was detectable by ELISA assays in supernatants of in vitro cultures of Con A-stimulated splenic T cells derived from homozygous mice following infection with the nematode N. brasiliensis. [MGI Ref ID J:15222]


Genotyping Information

Genotyping Protocols

Il10tm1Cgn, High Resolution Melting
Il10tm1Cgn, Standard PCR

Helpful Links

Genotyping resources and troubleshooting


References provided by MGI

Additional References

Casp1tm1Sesh related

Aachoui Y; Leaf IA; Hagar JA; Fontana MF; Campos CG; Zak DE; Tan MH; Cotter PA; Vance RE; Aderem A; Miao EA. 2013. Caspase-11 protects against bacteria that escape the vacuole. Science 339(6122):975-8. [PubMed: 23348507]  [MGI Ref ID J:193387]

Anthony DA; Andrews DM; Chow M; Watt SV; House C; Akira S; Bird PI; Trapani JA; Smyth MJ. 2010. A role for granzyme M in TLR4-driven inflammation and endotoxicosis. J Immunol 185(3):1794-803. [PubMed: 20585036]  [MGI Ref ID J:162467]

Antonopoulos C; Cumberbatch M; Dearman RJ; Daniel RJ; Kimber I; Groves RW. 2001. Functional caspase-1 is required for Langerhans cell migration and optimal contact sensitization in mice. J Immunol 166(6):3672-7. [PubMed: 11238606]  [MGI Ref ID J:124939]

Antonopoulos C; Cumberbatch M; Mee JB; Dearman RJ; Wei XQ; Liew FY; Kimber I; Groves RW. 2008. IL-18 is a key proximal mediator of contact hypersensitivity and allergen-induced Langerhans cell migration in murine epidermis. J Leukoc Biol 83(2):361-7. [PubMed: 17984289]  [MGI Ref ID J:145093]

Antonopoulos C; El Sanadi C; Kaiser WJ; Mocarski ES; Dubyak GR. 2013. Proapoptotic chemotherapeutic drugs induce noncanonical processing and release of IL-1beta via caspase-8 in dendritic cells. J Immunol 191(9):4789-803. [PubMed: 24078693]  [MGI Ref ID J:206238]

Barry KC; Fontana MF; Portman JL; Dugan AS; Vance RE. 2013. IL-1alpha signaling initiates the inflammatory response to virulent Legionella pneumophila in vivo. J Immunol 190(12):6329-39. [PubMed: 23686480]  [MGI Ref ID J:204844]

Boyden ED; Dietrich WF. 2006. Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin Nat Genet 38(2):240-244. [PubMed: 16429160]  [MGI Ref ID J:99748]

Chamberlain J; Evans D; King A; Dewberry R; Dower S; Crossman D; Francis S. 2006. Interleukin-1beta and signaling of interleukin-1 in vascular wall and circulating cells modulates the extent of neointima formation in mice. Am J Pathol 168(4):1396-403. [PubMed: 16565512]  [MGI Ref ID J:107324]

Cheng W; Shivshankar P; Li Z; Chen L; Yeh IT; Zhong G. 2008. Caspase-1 contributes to Chlamydia trachomatis-induced upper urogenital tract inflammatory pathologies without affecting the course of infection. Infect Immun 76(2):515-22. [PubMed: 18025098]  [MGI Ref ID J:130235]

Coers J; Vance RE; Fontana MF; Dietrich WF. 2007. Restriction of Legionella pneumophila growth in macrophages requires the concerted action of cytokine and Naip5/Ipaf signalling pathways. Cell Microbiol 9(10):2344-57. [PubMed: 17506816]  [MGI Ref ID J:148669]

Cumberbatch M; Dearman RJ; Antonopoulos C; Groves RW; Kimber I. 2001. Interleukin (IL)-18 induces Langerhans cell migration by a tumour necrosis factor-alpha- and IL-1beta-dependent mechanism. Immunology 102(3):323-30. [PubMed: 11298831]  [MGI Ref ID J:68644]

Desbien AL; Reed SJ; Bailor HR; Dubois Cauwelaert N; Laurance JD; Orr MT; Fox CB; Carter D; Reed SG; Duthie MS. 2015. Squalene emulsion potentiates the adjuvant activity of the TLR4 agonist, GLA, via inflammatory caspases, IL-18, and IFN-gamma. Eur J Immunol 45(2):407-17. [PubMed: 25367751]  [MGI Ref ID J:222315]

Dewamitta SR; Nomura T; Kawamura I; Hara H; Tsuchiya K; Kurenuma T; Shen Y; Daim S; Yamamoto T; Qu H; Sakai S; Xu Y; Mitsuyama M. 2010. Listeriolysin O-dependent bacterial entry into the cytoplasm is required for calpain activation and interleukin-1 alpha secretion in macrophages infected with Listeria monocytogenes. Infect Immun 78(5):1884-94. [PubMed: 20194588]  [MGI Ref ID J:160087]

Dixon LJ; Flask CA; Papouchado BG; Feldstein AE; Nagy LE. 2013. Caspase-1 as a central regulator of high fat diet-induced non-alcoholic steatohepatitis. PLoS One 8(2):e56100. [PubMed: 23409132]  [MGI Ref ID J:198314]

Dorhoi A; Nouailles G; Jorg S; Hagens K; Heinemann E; Pradl L; Oberbeck-Muller D; Duque-Correa MA; Reece ST; Ruland J; Brosch R; Tschopp J; Gross O; Kaufmann SH. 2012. Activation of the NLRP3 inflammasome by Mycobacterium tuberculosis is uncoupled from susceptibility to active tuberculosis. Eur J Immunol 42(2):374-84. [PubMed: 22101787]  [MGI Ref ID J:179821]

Edelson BT; Unanue ER. 2002. MyD88-dependent but Toll-like receptor 2-independent innate immunity to Listeria: no role for either in macrophage listericidal activity. J Immunol 169(7):3869-75. [PubMed: 12244184]  [MGI Ref ID J:120406]

Ewald SE; Chavarria-Smith J; Boothroyd JC. 2014. NLRP1 is an inflammasome sensor for Toxoplasma gondii. Infect Immun 82(1):460-8. [PubMed: 24218483]  [MGI Ref ID J:206165]

Feliciani C; Toto P; Amerio P; Pour SM; Coscione G; Shivji G; Wang B; Sauder DN. 2000. In vitro and in vivo expression of interleukin-1alpha and tumor necrosis factor-alpha mRNA in pemphigus vulgaris: interleukin-1alpha and tumor necrosis factor-alpha are involved in acantholysis. J Invest Dermatol 114(1):71-7. [PubMed: 10620118]  [MGI Ref ID J:127060]

Freigang S; Ampenberger F; Spohn G; Heer S; Shamshiev AT; Kisielow J; Hersberger M; Yamamoto M; Bachmann MF; Kopf M. 2011. Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis. Eur J Immunol 41(7):2040-51. [PubMed: 21484785]  [MGI Ref ID J:177309]

Freigang S; Ampenberger F; Weiss A; Kanneganti TD; Iwakura Y; Hersberger M; Kopf M. 2013. Fatty acid-induced mitochondrial uncoupling elicits inflammasome-independent IL-1alpha and sterile vascular inflammation in atherosclerosis. Nat Immunol 14(10):1045-53. [PubMed: 23995233]  [MGI Ref ID J:208219]

Gehrig A; Janssen A; Horling F; Grimm C; Weber BH. 2006. The role of caspases in photoreceptor cell death of the retinoschisin-deficient mouse. Cytogenet Genome Res 115(1):35-44. [PubMed: 16974082]  [MGI Ref ID J:112879]

Gross O; Poeck H; Bscheider M; Dostert C; Hannesschlager N; Endres S; Hartmann G; Tardivel A; Schweighoffer E; Tybulewicz V; Mocsai A; Tschopp J; Ruland J. 2009. Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence. Nature 459(7245):433-6. [PubMed: 19339971]  [MGI Ref ID J:148538]

Gurung P; Karki R; Vogel P; Watanabe M; Bix M; Lamkanfi M; Kanneganti TD. 2015. An NLRP3 inflammasome-triggered Th2-biased adaptive immune response promotes leishmaniasis. J Clin Invest 125(3):1329-38. [PubMed: 25689249]  [MGI Ref ID J:220540]

Hagar JA; Powell DA; Aachoui Y; Ernst RK; Miao EA. 2013. Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock. Science 341(6151):1250-3. [PubMed: 24031018]  [MGI Ref ID J:201144]

Hanamsagar R; Aldrich A; Kielian T. 2014. Critical role for the AIM2 inflammasome during acute CNS bacterial infection. J Neurochem 129(4):704-11. [PubMed: 24484406]  [MGI Ref ID J:208779]

Hanley PJ; Kronlage M; Kirschning C; del Rey A; Di Virgilio F; Leipziger J; Chessell IP; Sargin S; Filippov MA; Lindemann O; Mohr S; Konigs V; Schillers H; Bahler M; Schwab A. 2012. Transient P2X7 receptor activation triggers macrophage death independent of Toll-like receptors 2 and 4, caspase-1, and pannexin-1 proteins. J Biol Chem 287(13):10650-63. [PubMed: 22235111]  [MGI Ref ID J:183298]

Heneka MT; Kummer MP; Stutz A; Delekate A; Schwartz S; Vieira-Saecker A; Griep A; Axt D; Remus A; Tzeng TC; Gelpi E; Halle A; Korte M; Latz E; Golenbock DT. 2013. NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature 493(7434):674-8. [PubMed: 23254930]  [MGI Ref ID J:194405]

Henry T; Brotcke A; Weiss DS; Thompson LJ; Monack DM. 2007. Type I interferon signaling is required for activation of the inflammasome during Francisella infection. J Exp Med 204(5):987-94. [PubMed: 17452523]  [MGI Ref ID J:125737]

Jamilloux Y; Pierini R; Querenet M; Juruj C; Fauchais AL; Jauberteau MO; Jarraud S; Lina G; Etienne J; Roy CR; Henry T; Davoust N; Ader F. 2013. Inflammasome activation restricts Legionella pneumophila replication in primary microglial cells through flagellin detection. Glia 61(4):539-49. [PubMed: 23355222]  [MGI Ref ID J:193477]

Jayaraman P; Sada-Ovalle I; Beladi S; Anderson AC; Dardalhon V; Hotta C; Kuchroo VK; Behar SM. 2010. Tim3 binding to galectin-9 stimulates antimicrobial immunity. J Exp Med 207(11):2343-54. [PubMed: 20937702]  [MGI Ref ID J:166066]

Jehl SP; Doling AM; Giddings KS; Phalipon A; Sansonetti PJ; Goldberg MB; Starnbach MN. 2011. Antigen-Specific CD8+ T Cells Fail To Respond to Shigella flexneri. Infect Immun 79(5):2021-30. [PubMed: 21357720]  [MGI Ref ID J:171947]

Jolicoeur P; Hu C; Mak TW; Martinou JC; Kay DG. 2003. Protection against murine leukemia virus-induced spongiform myeloencephalopathy in mice overexpressing Bcl-2 but not in mice deficient for interleukin-6, inducible nitric oxide synthetase, ICE, Fas, Fas ligand, or TNF-R1 genes. J Virol 77(24):13161-70. [PubMed: 14645573]  [MGI Ref ID J:86761]

Kang TJ; Basu S; Zhang L; Thomas KE; Vogel SN; Baillie L; Cross AS. 2008. Bacillus anthracis spores and lethal toxin induce IL-1beta via functionally distinct signaling pathways. Eur J Immunol 38(6):1574-84. [PubMed: 18493980]  [MGI Ref ID J:136368]

Kayagaki N; Warming S; Lamkanfi M; Vande Walle L; Louie S; Dong J; Newton K; Qu Y; Liu J; Heldens S; Zhang J; Lee WP; Roose-Girma M; Dixit VM. 2011. Non-canonical inflammasome activation targets caspase-11. Nature 479(7371):117-21. [PubMed: 22002608]  [MGI Ref ID J:193522]

Kistowska M; Gehrke S; Jankovic D; Kerl K; Fettelschoss A; Feldmeyer L; Fenini G; Kolios A; Navarini A; Ganceviciene R; Schauber J; Contassot E; French LE. 2014. IL-1beta Drives Inflammatory Responses to Propionibacterium acnes In Vitro and In Vivo. J Invest Dermatol 134(3):677-85. [PubMed: 24157462]  [MGI Ref ID J:206191]

Kordes M; Matuschewski K; Hafalla JC. 2011. Caspase-1 Activation of Interleukin-1{beta} (IL-1{beta}) and IL-18 Is Dispensable for Induction of Experimental Cerebral Malaria. Infect Immun 79(9):3633-41. [PubMed: 21708993]  [MGI Ref ID J:175707]

Leibundgut-Landmann S; Weidner K; Hilbi H; Oxenius A. 2011. Nonhematopoietic cells are key players in innate control of bacterial airway infection. J Immunol 186(5):3130-7. [PubMed: 21270399]  [MGI Ref ID J:169394]

Li P; Allen H; Banerjee S; Franklin S; Herzog L; Johnston C; McDowell J; Paskind M; Rodman L; Salfeld J; Towne E; Tracey D; Wardwell S; Wei FY; Wong W; Kamen R; Seshadri T. 1995. Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock. Cell 80(3):401-11. [PubMed: 7859282]  [MGI Ref ID J:22964]

Li P; Allen H; Banerjee S; Seshadri T. 1997. Characterization of mice deficient in interleukin-1 beta converting enzyme. J Cell Biochem 64(1):27-32. [PubMed: 9015751]  [MGI Ref ID J:40691]

Lichtnekert J; Kulkarni OP; Mulay SR; Rupanagudi KV; Ryu M; Allam R; Vielhauer V; Muruve D; Lindenmeyer MT; Cohen CD; Anders HJ. 2011. Anti-GBM Glomerulonephritis Involves IL-1 but Is Independent of NLRP3/ASC Inflammasome-Mediated Activation of Caspase-1. PLoS One 6(10):e26778. [PubMed: 22046355]  [MGI Ref ID J:178074]

Liege S; Moze E; Kelley KW; Parnet P; Neveu PJ. 2000. Activation of the hypothalamic-pituitary-adrenal axis in IL-1 beta-converting enzyme-deficient mice. Neuroimmunomodulation 7(4):189-94. [PubMed: 10810251]  [MGI Ref ID J:62433]

Lightfield KL; Persson J; Brubaker SW; Witte CE; von Moltke J; Dunipace EA; Henry T; Sun YH; Cado D; Dietrich WF; Monack DM; Tsolis RM; Vance RE. 2008. Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin. Nat Immunol 9(10):1171-8. [PubMed: 18724372]  [MGI Ref ID J:141008]

Liu XH; Kwon D; Schielke GP; Yang GY; Silverstein FS; Barks JD. 1999. Mice deficient in interleukin-1 converting enzyme are resistant to neonatal hypoxic-ischemic brain damage. J Cereb Blood Flow Metab 19(10):1099-108. [PubMed: 10532634]  [MGI Ref ID J:98866]

MacDuff DA; Reese TA; Kimmey JM; Weiss LA; Song C; Zhang X; Kambal A; Duan E; Carrero JA; Boisson B; Laplantine E; Israel A; Picard C; Colonna M; Edelson BT; Sibley LD; Stallings CL; Casanova JL; Iwai K; Virgin HW. 2015. Phenotypic complementation of genetic immunodeficiency by chronic herpesvirus infection. Elife 4:. [PubMed: 25599590]  [MGI Ref ID J:219574]

Man SM; Ekpenyong A; Tourlomousis P; Achouri S; Cammarota E; Hughes K; Rizzo A; Ng G; Wright JA; Cicuta P; Guck JR; Bryant CE. 2014. Actin polymerization as a key innate immune effector mechanism to control Salmonella infection. Proc Natl Acad Sci U S A 111(49):17588-93. [PubMed: 25422455]  [MGI Ref ID J:216797]

Mankan AK; Canli O; Schwitalla S; Ziegler P; Tschopp J; Korn T; Greten FR. 2011. TNF-{alpha}-dependent loss of IKK{beta}-deficient myeloid progenitors triggers a cytokine loop culminating in granulocytosis. Proc Natl Acad Sci U S A 108(16):6567-72. [PubMed: 21464320]  [MGI Ref ID J:171365]

Mariathasan S; Weiss DS; Dixit VM; Monack DM. 2005. Innate immunity against Francisella tularensis is dependent on the ASC/caspase-1 axis. J Exp Med 202(8):1043-9. [PubMed: 16230474]  [MGI Ref ID J:116821]

Masters SL; Gerlic M; Metcalf D; Preston S; Pellegrini M; O'Donnell JA; McArthur K; Baldwin TM; Chevrier S; Nowell CJ; Cengia LH; Henley KJ; Collinge JE; Kastner DL; Feigenbaum L; Hilton DJ; Alexander WS; Kile BT; Croker BA. 2012. NLRP1 Inflammasome Activation Induces Pyroptosis of Hematopoietic Progenitor Cells. Immunity 37(6):1009-23. [PubMed: 23219391]  [MGI Ref ID J:191055]

Mastronardi C; Whelan F; Yildiz OA; Hannestad J; Elashoff D; McCann SM; Licinio J; Wong ML. 2007. Caspase 1 deficiency reduces inflammation-induced brain transcription. Proc Natl Acad Sci U S A 104(17):7205-10. [PubMed: 17409187]  [MGI Ref ID J:120877]

Meissner F; Molawi K; Zychlinsky A. 2008. Superoxide dismutase 1 regulates caspase-1 and endotoxic shock. Nat Immunol 9(8):866-72. [PubMed: 18604212]  [MGI Ref ID J:137865]

Meunier E; Dick MS; Dreier RF; Schurmann N; Kenzelmann Broz D; Warming S; Roose-Girma M; Bumann D; Kayagaki N; Takeda K; Yamamoto M; Broz P. 2014. Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases. Nature 509(7500):366-70. [PubMed: 24739961]  [MGI Ref ID J:210626]

Miggin SM; Palsson-McDermott E; Dunne A; Jefferies C; Pinteaux E; Banahan K; Murphy C; Moynagh P; Yamamoto M; Akira S; Rothwell N; Golenbock D; Fitzgerald KA; O'Neill LA. 2007. NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1. Proc Natl Acad Sci U S A 104(9):3372-7. [PubMed: 17360653]  [MGI Ref ID J:125936]

Miwa K; Asano M; Horai R; Iwakura Y; Nagata S; Suda T. 1998. Caspase 1-independent IL-1beta release and inflammation induced by the apoptosis inducer Fas ligand. Nat Med 4(11):1287-92. [PubMed: 9809553]  [MGI Ref ID J:50775]

Moayeri M; Crown D; Newman ZL; Okugawa S; Eckhaus M; Cataisson C; Liu S; Sastalla I; Leppla SH. 2010. Inflammasome sensor Nlrp1b-dependent resistance to anthrax is mediated by caspase-1, IL-1 signaling and neutrophil recruitment. PLoS Pathog 6(12):e1001222. [PubMed: 21170303]  [MGI Ref ID J:168096]

Monack DM; Hersh D; Ghori N; Bouley D; Zychlinsky A; Falkow S. 2000. Salmonella exploits caspase-1 to colonize Peyer's patches in a murine typhoid model. J Exp Med 192(2):249-58. [PubMed: 10899911]  [MGI Ref ID J:63488]

Moreth K; Brodbeck R; Babelova A; Gretz N; Spieker T; Zeng-Brouwers J; Pfeilschifter J; Young MF; Schaefer RM; Schaefer L. 2010. The proteoglycan biglycan regulates expression of the B cell chemoattractant CXCL13 and aggravates murine lupus nephritis. J Clin Invest 120(12):4251-72. [PubMed: 21084753]  [MGI Ref ID J:171866]

Murphey ED. 2011. Cecal ligation and puncture-induced impairment of innate immune function does not occur in the absence of caspase-1. J Immunol 187(2):905-10. [PubMed: 21677131]  [MGI Ref ID J:178035]

Pilla DM; Hagar JA; Haldar AK; Mason AK; Degrandi D; Pfeffer K; Ernst RK; Yamamoto M; Miao EA; Coers J. 2014. Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS. Proc Natl Acad Sci U S A 111(16):6046-51. [PubMed: 24715728]  [MGI Ref ID J:208845]

Priceputu E; Rodrigue I; Chrobak P; Poudrier J; Mak TW; Hanna Z; Hu C; Kay DG; Jolicoeur P. 2005. The Nef-mediated AIDS-like disease of CD4C/human immunodeficiency virus transgenic mice is associated with increased Fas/FasL expression on T cells and T-cell death but is not prevented in Fas-, FasL-, tumor necrosis factor receptor 1-, or interleukin-1beta-converting enzyme-deficient or Bcl2-expressing transgenic mice. J Virol 79(10):6377-91. [PubMed: 15858021]  [MGI Ref ID J:98353]

Raupach B; Peuschel SK; Monack DM; Zychlinsky A. 2006. Caspase-1-mediated activation of interleukin-1beta (IL-1beta) and IL-18 contributes to innate immune defenses against Salmonella enterica serovar Typhimurium infection. Infect Immun 74(8):4922-6. [PubMed: 16861683]  [MGI Ref ID J:112400]

Rosenzweig HL; Galster KT; Planck SR; Rosenbaum JT. 2009. NOD1 expression in the eye and functional contribution to IL-1beta-dependent ocular inflammation in mice. Invest Ophthalmol Vis Sci 50(4):1746-53. [PubMed: 19074813]  [MGI Ref ID J:146667]

Rosenzweig HL; Martin TM; Planck SR; Galster K; Jann MM; Davey MP; Kobayashi K; Flavell RA; Rosenbaum JT. 2008. Activation of NOD2 in vivo induces IL-1beta production in the eye via caspase-1 but results in ocular inflammation independently of IL-1 signaling. J Leukoc Biol 84(2):529-36. [PubMed: 18495787]  [MGI Ref ID J:138433]

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Samardzija M; Wenzel A; Thiersch M; Frigg R; Reme C; Grimm C. 2006. Caspase-1 ablation protects photoreceptors in a model of autosomal dominant retinitis pigmentosa. Invest Ophthalmol Vis Sci 47(12):5181-90. [PubMed: 17122101]  [MGI Ref ID J:123100]

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Schott WH; Haskell BD; Tse HM; Milton MJ; Piganelli JD; Choisy-Rossi CM; Reifsnyder PC; Chervonsky AV; Leiter EH. 2004. Caspase-1 Is Not Required for Type 1 Diabetes in the NOD Mouse. Diabetes 53(1):99-104. [PubMed: 14693703]  [MGI Ref ID J:87250]

Serbina NV; Hohl TM; Cherny M; Pamer EG. 2009. Selective expansion of the monocytic lineage directed by bacterial infection. J Immunol 183(3):1900-10. [PubMed: 19596996]  [MGI Ref ID J:151581]

Sundquist M; Wick MJ. 2005. TNF-alpha-dependent and -independent maturation of dendritic cells and recruited CD11c(int)CD11b+ Cells during oral Salmonella infection. J Immunol 175(5):3287-98. [PubMed: 16116221]  [MGI Ref ID J:113214]

Tang H; Cao W; Kasturi SP; Ravindran R; Nakaya HI; Kundu K; Murthy N; Kepler TB; Malissen B; Pulendran B. 2010. The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling. Nat Immunol 11(7):608-17. [PubMed: 20495560]  [MGI Ref ID J:161857]

Tonti E; Jimenez de Oya N; Galliverti G; Moseman EA; Di Lucia P; Amabile A; Sammicheli S; De Giovanni M; Sironi L; Chevrier N; Sitia G; Gennari L; Guidotti LG; von Andrian UH; Iannacone M. 2013. Bisphosphonates target B cells to enhance humoral immune responses. Cell Rep 5(2):323-30. [PubMed: 24120862]  [MGI Ref ID J:203773]

Trunk G; Oxenius A. 2012. Innate instruction of CD4+ T cell immunity in respiratory bacterial infection. J Immunol 189(2):616-28. [PubMed: 22723524]  [MGI Ref ID J:189793]

Vande Walle L; Van Opdenbosch N; Jacques P; Fossoul A; Verheugen E; Vogel P; Beyaert R; Elewaut D; Kanneganti TD; van Loo G; Lamkanfi M. 2014. Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis. Nature 512(7512):69-73. [PubMed: 25043000]  [MGI Ref ID J:217119]

Vladimer GI; Weng D; Paquette SW; Vanaja SK; Rathinam VA; Aune MH; Conlon JE; Burbage JJ; Proulx MK; Liu Q; Reed G; Mecsas JC; Iwakura Y; Bertin J; Goguen JD; Fitzgerald KA; Lien E. 2012. The NLRP12 inflammasome recognizes Yersinia pestis. Immunity 37(1):96-107. [PubMed: 22840842]  [MGI Ref ID J:187388]

Wickstrum JR; Bokhari SM; Fischer JL; Pinson DM; Yeh HW; Horvat RT; Parmely MJ. 2009. Francisella tularensis induces extensive caspase-3 activation and apoptotic cell death in the tissues of infected mice. Infect Immun 77(11):4827-36. [PubMed: 19703976]  [MGI Ref ID J:154196]

Wong ML; Xie B; Beatini N; Phu P; Marathe S; Johns A; Gold PW; Hirsch E; Williams KJ; Licinio J; Tabas I. 2000. Acute systemic inflammation up-regulates secretory sphingomyelinase in vivo: A possible link between inflammatory cytokines and atherogenesis Proc Natl Acad Sci U S A 97(15):8681-6. [PubMed: 10890909]  [MGI Ref ID J:63405]

Xu H; Barks JD; Schielke GP; Silverstein FS. 2001. Attenuation of hypoxia-ischemia-induced monocyte chemoattractant protein-1 expression in brain of neonatal mice deficient in interleukin-1 converting enzyme. Brain Res Mol Brain Res 90(1):57-67. [PubMed: 11376856]  [MGI Ref ID J:69589]

Yang GY; Schielke GP; Gong C; Mao Y; Ge HL; Liu XH; Betz AL. 1999. Expression of tumor necrosis factor-alpha and intercellular adhesion molecule-1 after focal cerebral ischemia in interleukin-1beta converting enzyme deficient mice. J Cereb Blood Flow Metab 19(10):1109-17. [PubMed: 10532635]  [MGI Ref ID J:59704]

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Zhao Y; Yang J; Shi J; Gong YN; Lu Q; Xu H; Liu L; Shao F. 2011. The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus. Nature 477(7366):596-600. [PubMed: 21918512]  [MGI Ref ID J:177040]

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van der Velden AW; Velasquez M; Starnbach MN. 2003. Salmonella rapidly kill dendritic cells via a caspase-1-dependent mechanism. J Immunol 171(12):6742-9. [PubMed: 14662878]  [MGI Ref ID J:118499]

Casp4del related

Aachoui Y; Leaf IA; Hagar JA; Fontana MF; Campos CG; Zak DE; Tan MH; Cotter PA; Vance RE; Aderem A; Miao EA. 2013. Caspase-11 protects against bacteria that escape the vacuole. Science 339(6122):975-8. [PubMed: 23348507]  [MGI Ref ID J:193387]

Desbien AL; Reed SJ; Bailor HR; Dubois Cauwelaert N; Laurance JD; Orr MT; Fox CB; Carter D; Reed SG; Duthie MS. 2015. Squalene emulsion potentiates the adjuvant activity of the TLR4 agonist, GLA, via inflammatory caspases, IL-18, and IFN-gamma. Eur J Immunol 45(2):407-17. [PubMed: 25367751]  [MGI Ref ID J:222315]

Gurung P; Karki R; Vogel P; Watanabe M; Bix M; Lamkanfi M; Kanneganti TD. 2015. An NLRP3 inflammasome-triggered Th2-biased adaptive immune response promotes leishmaniasis. J Clin Invest 125(3):1329-38. [PubMed: 25689249]  [MGI Ref ID J:220540]

Kayagaki N; Warming S; Lamkanfi M; Vande Walle L; Louie S; Dong J; Newton K; Qu Y; Liu J; Heldens S; Zhang J; Lee WP; Roose-Girma M; Dixit VM. 2011. Non-canonical inflammasome activation targets caspase-11. Nature 479(7371):117-21. [PubMed: 22002608]  [MGI Ref ID J:193522]

MacDuff DA; Reese TA; Kimmey JM; Weiss LA; Song C; Zhang X; Kambal A; Duan E; Carrero JA; Boisson B; Laplantine E; Israel A; Picard C; Colonna M; Edelson BT; Sibley LD; Stallings CL; Casanova JL; Iwai K; Virgin HW. 2015. Phenotypic complementation of genetic immunodeficiency by chronic herpesvirus infection. Elife 4:. [PubMed: 25599590]  [MGI Ref ID J:219574]

Masters SL; Gerlic M; Metcalf D; Preston S; Pellegrini M; O'Donnell JA; McArthur K; Baldwin TM; Chevrier S; Nowell CJ; Cengia LH; Henley KJ; Collinge JE; Kastner DL; Feigenbaum L; Hilton DJ; Alexander WS; Kile BT; Croker BA. 2012. NLRP1 Inflammasome Activation Induces Pyroptosis of Hematopoietic Progenitor Cells. Immunity 37(6):1009-23. [PubMed: 23219391]  [MGI Ref ID J:191055]

Place DE; Muse SJ; Kirimanjeswara GS; Harvill ET. 2014. Caspase-1-independent interleukin-1beta is required for clearance of Bordetella pertussis infections and whole-cell vaccine-mediated immunity. PLoS One 9(9):e107188. [PubMed: 25198773]  [MGI Ref ID J:221522]

Wynosky-Dolfi MA; Snyder AG; Philip NH; Doonan PJ; Poffenberger MC; Avizonis D; Zwack EE; Riblett AM; Hu B; Strowig T; Flavell RA; Jones RG; Freedman BD; Brodsky IE. 2014. Oxidative metabolism enables Salmonella evasion of the NLRP3 inflammasome. J Exp Med 211(4):653-68. [PubMed: 24638169]  [MGI Ref ID J:211688]

Il10tm1Cgn related

Aggarwal NR; Tsushima K; Eto Y; Tripathi A; Mandke P; Mock JR; Garibaldi BT; Singer BD; Sidhaye VK; Horton MR; King LS; D'Alessio FR. 2014. Immunological priming requires regulatory T cells and IL-10-producing macrophages to accelerate resolution from severe lung inflammation. J Immunol 192(9):4453-64. [PubMed: 24688024]  [MGI Ref ID J:209966]

Akhiani AA; Stensson A; Schon K; Lycke NY. 2005. IgA antibodies impair resistance against Helicobacter pylori infection: studies on immune evasion in IL-10-deficient mice. J Immunol 174(12):8144-53. [PubMed: 15944323]  [MGI Ref ID J:100891]

Alayan J; Ivanovski S; Farah CS. 2007. Alveolar bone loss in T helper 1/T helper 2 cytokine-deficient mice. J Periodontal Res 42(2):97-103. [PubMed: 17305866]  [MGI Ref ID J:147935]

Albert E; Walker J; Thiesen A; Churchill T; Madsen K. 2010. cis-Urocanic acid attenuates acute dextran sodium sulphate-induced intestinal inflammation. PLoS One 5(10):e13676. [PubMed: 21060867]  [MGI Ref ID J:166665]

Aliberti J; Viola JP; Vieira-de-Abreu A; Bozza PT; Sher A; Scharfstein J. 2003. Cutting edge: Bradykinin induces IL-12 production by dendritic cells: a danger signal that drives Th1 polarization. J Immunol 170(11):5349-53. [PubMed: 12759407]  [MGI Ref ID J:83453]

Allen HL; Deepe GS Jr. 2005. Apoptosis modulates protective immunity to the pathogenic fungus Histoplasma capsulatum. J Clin Invest 115(10):2875-85. [PubMed: 16151533]  [MGI Ref ID J:101533]

Allen HL; Deepe GS Jr. 2006. B cells and CD4-CD8- T cells are key regulators of the severity of reactivation histoplasmosis. J Immunol 177(3):1763-71. [PubMed: 16849486]  [MGI Ref ID J:138028]

Almeida AR; Legrand N; Papiernik M; Freitas AA. 2002. Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers. J Immunol 169(9):4850-60. [PubMed: 12391195]  [MGI Ref ID J:125748]

Amante FH; Stanley AC; Randall LM; Zhou Y; Haque A; McSweeney K; Waters AP; Janse CJ; Good MF; Hill GR; Engwerda CR. 2007. A role for natural regulatory T cells in the pathogenesis of experimental cerebral malaria. Am J Pathol 171(2):548-59. [PubMed: 17600128]  [MGI Ref ID J:123927]

Ameredes BT; Sethi JM; Liu HL; Choi AM; Calhoun WJ. 2005. Enhanced nitric oxide production associated with airway hyporesponsiveness in the absence of IL-10. Am J Physiol Lung Cell Mol Physiol 288(5):L868-73. [PubMed: 15618456]  [MGI Ref ID J:115459]

Ameredes BT; Zamora R; Gibson KF; Billiar TR; Dixon-McCarthy B; Watkins S; Calhoun WJ. 2001. Increased nitric oxide production by airway cells of sensitized and challenged IL-10 knockout mice. J Leukoc Biol 70(5):730-6. [PubMed: 11698492]  [MGI Ref ID J:124461]

Ameredes BT; Zamora R; Sethi JM; Liu HL; Kohut LK; Gligonic AL; Choi AM; Calhoun WJ. 2005. Alterations in nitric oxide and cytokine production with airway inflammation in the absence of IL-10. J Immunol 175(2):1206-13. [PubMed: 16002724]  [MGI Ref ID J:100726]

Ananieva O; Darragh J; Johansen C; Carr JM; McIlrath J; Park JM; Wingate A; Monk CE; Toth R; Santos SG; Iversen L; Arthur JS. 2008. The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling. Nat Immunol 9(9):1028-36. [PubMed: 18690222]  [MGI Ref ID J:139576]

Anderson AC; Reddy J; Nazareno R; Sobel RA; Nicholson LB; Kuchroo VK. 2004. IL-10 plays an important role in the homeostatic regulation of the autoreactive repertoire in naive mice. J Immunol 173(2):828-34. [PubMed: 15240669]  [MGI Ref ID J:91913]

Anderson CF; Oukka M; Kuchroo VJ; Sacks D. 2007. CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis. J Exp Med 204(2):285-97. [PubMed: 17283207]  [MGI Ref ID J:125372]

Andou A; Hisamatsu T; Okamoto S; Chinen H; Kamada N; Kobayashi T; Hashimoto M; Okutsu T; Shimbo K; Takeda T; Matsumoto H; Sato A; Ohtsu H; Suzuki M; Hibi T. 2009. Dietary histidine ameliorates murine colitis by inhibition of proinflammatory cytokine production from macrophages. Gastroenterology 136(2):564-74.e2. [PubMed: 19027739]  [MGI Ref ID J:145874]

Andrade EB; Alves J; Madureira P; Oliveira L; Ribeiro A; Cordeiro-da-Silva A; Correia-Neves M; Trieu-Cuot P; Ferreira P. 2013. TLR2-induced IL-10 production impairs neutrophil recruitment to infected tissues during neonatal bacterial sepsis. J Immunol 191(9):4759-68. [PubMed: 24078699]  [MGI Ref ID J:206234]

Andrassy M; Igwe J; Autschbach F; Volz C; Remppis A; Neurath MF; Schleicher E; Humpert PM; Wendt T; Liliensiek B; Morcos M; Schiekofer S; Thiele K; Chen J; Kientsch-Engel R; Schmidt AM; Stremmel W; Stern DM; Katus HA; Nawroth PP; Bierhaus A. 2006. Posttranslationally modified proteins as mediators of sustained intestinal inflammation. Am J Pathol 169(4):1223-37. [PubMed: 17003481]  [MGI Ref ID J:113376]

Ankathatti Munegowda M; Xu S; Freywald A; Xiang J. 2012. CD4+ Th2 cells function alike effector Tr1 and Th1 cells through the deletion of a single cytokine IL-6 and IL-10 gene. Mol Immunol 51(2):143-9. [PubMed: 22424785]  [MGI Ref ID J:184874]

Apte RS; Richter J; Herndon J; Ferguson TA. 2006. Macrophages inhibit neovascularization in a murine model of age-related macular degeneration. PLoS Med 3(8):e310. [PubMed: 16903779]  [MGI Ref ID J:134144]

Arrieta MC; Madsen K; Doyle J; Meddings J. 2009. Reducing small intestinal permeability attenuates colitis in the IL10 gene-deficient mouse. Gut 58(1):41-8. [PubMed: 18829978]  [MGI Ref ID J:213262]

Arsenescu R; Blum AM; Metwali A; Elliott DE; Weinstock JV. 2005. IL-12 induction of mRNA encoding substance P in murine macrophages from the spleen and sites of inflammation. J Immunol 174(7):3906-11. [PubMed: 15778345]  [MGI Ref ID J:110005]

Auerbuch V; Isberg RR. 2007. Growth of Yersinia pseudotuberculosis in Mice Occurs Independently of Toll-Like Receptor 2 Expression and Induction of Interleukin-10. Infect Immun 75(7):3561-70. [PubMed: 17420232]  [MGI Ref ID J:122417]

Aviszus K; Macleod MK; Kirchenbaum GA; Detanico TO; Heiser RA; St Clair JB; Guo W; Wysocki LJ. 2012. Antigen-specific suppression of humoral immunity by anergic Ars/A1 B cells. J Immunol 189(9):4275-83. [PubMed: 23008448]  [MGI Ref ID J:190617]

Awasthi A; Carrier Y; Peron JP; Bettelli E; Kamanaka M; Flavell RA; Kuchroo VK; Oukka M; Weiner HL. 2007. A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells. Nat Immunol 8(12):1380-9. [PubMed: 17994022]  [MGI Ref ID J:127774]

Bai F; Town T; Qian F; Wang P; Kamanaka M; Connolly TM; Gate D; Montgomery RR; Flavell RA; Fikrig E. 2009. IL-10 signaling blockade controls murine West Nile virus infection. PLoS Pathog 5(10):e1000610. [PubMed: 19816558]  [MGI Ref ID J:162907]

Balasa B; La Cava A; Van Gunst K; Mocnik L; Balakrishna D; Nguyen N; Tucker L; Sarvetnick N. 2000. A mechanism for IL-10-mediated diabetes in the nonobese diabetic (NOD) mouse: ICAM-1 deficiency blocks accelerated diabetes J Immunol 165(12):7330-7. [PubMed: 11120869]  [MGI Ref ID J:66103]

Balasa B; Van Gunst K; Jung N; Katz JD; Sarvetnick N. 2000. IL-10 deficiency does not inhibit insulitis and accelerates cyclophosphamide-induced diabetes in the nonobese diabetic mouse. Cell Immunol 202(2):97-102. [PubMed: 10896769]  [MGI Ref ID J:114170]

Bamboat ZM; Ocuin LM; Balachandran VP; Obaid H; Plitas G; Dematteo RP. 2010. Conventional DCs reduce liver ischemia/reperfusion injury in mice via IL-10 secretion. J Clin Invest 120(2):559-69. [PubMed: 20093775]  [MGI Ref ID J:156672]

Bandukwala HS; Clay BS; Tong J; Mody PD; Cannon JL; Shilling RA; Verbeek JS; Weinstock JV; Solway J; Sperling AI. 2007. Signaling through Fc gamma RIII is required for optimal T helper type (Th)2 responses and Th2-mediated airway inflammation. J Exp Med 204(8):1875-89. [PubMed: 17664287]  [MGI Ref ID J:125951]

Barbi J; Brombacher F; Satoskar AR. 2008. T Cells from Leishmania major-susceptible BALB/c mice have a defect in efficiently up-regulating CXCR3 upon activation. J Immunol 181(7):4613-20. [PubMed: 18802063]  [MGI Ref ID J:141294]

Bassaganya-Riera J; Viladomiu M; Pedragosa M; De Simone C; Hontecillas R. 2012. Immunoregulatory mechanisms underlying prevention of colitis-associated colorectal cancer by probiotic bacteria. PLoS One 7(4):e34676. [PubMed: 22511958]  [MGI Ref ID J:187088]

Beatty PL; Plevy SE; Sepulveda AR; Finn OJ. 2007. Cutting edge: transgenic expression of human MUC1 in IL-10-/- mice accelerates inflammatory bowel disease and progression to colon cancer. J Immunol 179(2):735-9. [PubMed: 17617560]  [MGI Ref ID J:149347]

Beckwith J; Cong Y; Sundberg JP; Elson CO; Leiter EH. 2005. Cdcs1, a major colitogenic locus in mice, regulates innate and adaptive immune response to enteric bacterial antigens. Gastroenterology 129(5):1473-84. [PubMed: 16285949]  [MGI Ref ID J:101721]

Beenhouwer DO; Shapiro S; Feldmesser M; Casadevall A; Scharff MD. 2001. Both Th1 and Th2 Cytokines Affect the Ability of Monoclonal Antibodies To Protect Mice against Cryptococcus neoformans. Infect Immun 69(10):6445-55. [PubMed: 11553589]  [MGI Ref ID J:71570]

Beissert S; Hosoi J; Kuhn R; Rajewsky K; Muller W; Granstein RD. 1996. Impaired immunosuppressive response to ultraviolet radiation in interleukin-10-deficient mice. J Invest Dermatol 107(4):553-7. [PubMed: 8823360]  [MGI Ref ID J:35510]

Beiting DP; Bliss SK; Schlafer DH; Roberts VL; Appleton JA. 2004. Interleukin-10 limits local and body cavity inflammation during infection with muscle-stage Trichinella spiralis. Infect Immun 72(6):3129-37. [PubMed: 15155614]  [MGI Ref ID J:90250]

Belkaid Y; Hoffmann KF; Mendez S; Kamhawi S; Udey MC; Wynn TA; Sacks DL. 2001. The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure. J Exp Med 194(10):1497-506. [PubMed: 11714756]  [MGI Ref ID J:118003]

Berg DJ; Davidson N; Kuhn R; Muller W; Menon S; Holland G; Thompson-Snipes L; Leach MW; Rennick D. 1996. Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses. J Clin Invest 98(4):1010-20. [PubMed: 8770874]  [MGI Ref ID J:35020]

Berg DJ; Leach MW; Kuhn R; Rajewsky K; Muller W; Davidson NJ; Rennick D. 1995. Interleukin 10 but not interleukin 4 is a natural suppressant of cutaneous inflammatory responses. J Exp Med 182(1):99-108. [PubMed: 7790826]  [MGI Ref ID J:26221]

Bernert H; Sekikawa K; Radcliffe RA; Iraqi F; You M; Malkinson AM. 2003. Tnfa and Il-10 deficiencies have contrasting effects on lung tumor susceptibility: Gender-dependent modulation of IL-10 haploinsufficiency. Mol Carcinog 38(3):117-23. [PubMed: 14587096]  [MGI Ref ID J:86489]

Bettelli E; Das MP; Howard ED; Weiner HL; Sobel RA; Kuchroo VK. 1998. IL-10 is critical in the regulation of autoimmune encephalomyelitis as demonstrated by studies of IL-10- and IL-4-deficient and transgenic mice. J Immunol 161(7):3299-306. [PubMed: 9759845]  [MGI Ref ID J:115204]

Bettenworth D; Buyse M; Bohm M; Mennigen R; Czorniak I; Kannengiesser K; Brzoska T; Luger TA; Kucharzik T; Domschke W; Maaser C; Lugering A. 2011. The tripeptide KdPT protects from intestinal inflammation and maintains intestinal barrier function. Am J Pathol 179(3):1230-42. [PubMed: 21741932]  [MGI Ref ID J:176323]

Bhattacharyya S; Deb J; Patra AK; Thuy Pham DA; Chen W; Vaeth M; Berberich-Siebelt F; Klein-Hessling S; Lamperti ED; Reifenberg K; Jellusova J; Schweizer A; Nitschke L; Leich E; Rosenwald A; Brunner C; Engelmann S; Bommhardt U; Avots A; Muller MR; Kondo E; Serfling E. 2011. NFATc1 affects mouse splenic B cell function by controlling the calcineurin--NFAT signaling network. J Exp Med 208(4):823-39. [PubMed: 21464221]  [MGI Ref ID J:177319]

Biburger M; Tiegs G. 2008. Activation-induced NKT cell hyporesponsiveness protects from alpha-galactosylceramide hepatitis and is independent of active transregulatory factors. J Leukoc Biol 84(1):264-79. [PubMed: 18407967]  [MGI Ref ID J:137749]

Biswas A; Wilmanski J; Forsman H; Hrncir T; Hao L; Tlaskalova-Hogenova H; Kobayashi KS. 2011. Negative regulation of Toll-like receptor signaling plays an essential role in homeostasis of the intestine. Eur J Immunol 41(1):182-94. [PubMed: 21182089]  [MGI Ref ID J:174655]

Bleich A; Buchler G; Beckwith J; Petell LM; Affourtit JP; King BL; Shaffer DJ; Roopenian DC; Hedrich HJ; Sundberg JP; Leiter EH. 2010. Cdcs1 a major colitis susceptibility locus in mice; subcongenic analysis reveals genetic complexity. Inflamm Bowel Dis 16(5):765-75. [PubMed: 19856416]  [MGI Ref ID J:171733]

Bleich A; Janus LM; Smoczek A; Westendorf AM; Strauch U; Mahler M; Hedrich HJ; Fichtner-Feigl S; Scholmerich J; Falk W; Hofmann C; Obermeier F. 2009. CpG motifs of bacterial DNA exert protective effects in mouse models of IBD by antigen-independent tolerance induction. Gastroenterology 136(1):278-87. [PubMed: 18952084]  [MGI Ref ID J:145618]

Bliss SK; Alcaraz A; Appleton JA. 2003. IL-10 prevents liver necrosis during murine infection with Trichinella spiralis. J Immunol 171(6):3142-7. [PubMed: 12960341]  [MGI Ref ID J:85372]

Bliss SK; Bliss SP; Beiting DP; Alcaraz A; Appleton JA. 2007. IL-10 regulates movement of intestinally derived CD4+ T cells to the liver. J Immunol 178(12):7974-83. [PubMed: 17548634]  [MGI Ref ID J:148582]

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Vishwakarma V; Pati NB; Chandel HS; Sahoo SS; Saha B; Suar M. 2012. Evaluation of Salmonella enterica serovar Typhimurium TTSS-2 deficient fur mutant as safe live-attenuated vaccine candidate for immunocompromised mice. PLoS One 7(12):e52043. [PubMed: 23284865]  [MGI Ref ID J:195626]

Walker WE; Goldstein DR. 2007. Neonatal B cells suppress innate toll-like receptor immune responses and modulate alloimmunity. J Immunol 179(3):1700-10. [PubMed: 17641036]  [MGI Ref ID J:149945]

Walsh KP; Brady MT; Finlay CM; Boon L; Mills KH. 2009. Infection with a helminth parasite attenuates autoimmunity through TGF-beta-mediated suppression of Th17 and Th1 responses. J Immunol 183(3):1577-86. [PubMed: 19587018]  [MGI Ref ID J:151701]

Wang B; Zhuang L; Fujisawa H; Shinder GA; Feliciani C; Shivji GM; Suzuki H; Amerio P; Toto P; Sauder DN. 1999. Enhanced epidermal Langerhans cell migration in IL-10 knockout mice. J Immunol 162(1):277-83. [PubMed: 9886396]  [MGI Ref ID J:51636]

Wang J; Cho S; Ueno A; Cheng L; Xu BY; Desrosiers MD; Shi Y; Yang Y. 2008. Ligand-dependent induction of noninflammatory dendritic cells by anergic invariant NKT cells minimizes autoimmune inflammation. J Immunol 181(4):2438-45. [PubMed: 18684934]  [MGI Ref ID J:140188]

Wang L; Gordon RA; Huynh L; Su X; Park Min KH; Han J; Arthur JS; Kalliolias GD; Ivashkiv LB. 2010. Indirect inhibition of Toll-like receptor and type I interferon responses by ITAM-coupled receptors and integrins. Immunity 32(4):518-30. [PubMed: 20362473]  [MGI Ref ID J:160755]

Wang Q; Fang CH; Hasselgren PO. 2001. Intestinal permeability is reduced and IL-10 levels are increased in septic IL-6 knockout mice. Am J Physiol Regul Integr Comp Physiol 281(3):R1013-23. [PubMed: 11507020]  [MGI Ref ID J:71507]

Wang RX; Yu CR; Dambuza IM; Mahdi RM; Dolinska MB; Sergeev YV; Wingfield PT; Kim SH; Egwuagu CE. 2014. Interleukin-35 induces regulatory B cells that suppress autoimmune disease. Nat Med 20(6):633-41. [PubMed: 24743305]  [MGI Ref ID J:213242]

Weaver BK; Bohn E; Judd BA; Gil MP; Schreiber RD. 2007. ABIN-3: a molecular basis for species divergence in interleukin-10-induced anti-inflammatory actions. Mol Cell Biol 27(13):4603-16. [PubMed: 17485448]  [MGI Ref ID J:122758]

Weiss KA; Christiaansen AF; Fulton RB; Meyerholz DK; Varga SM. 2011. Multiple CD4+ T cell subsets produce immunomodulatory IL-10 during respiratory syncytial virus infection. J Immunol 187(6):3145-54. [PubMed: 21844390]  [MGI Ref ID J:179242]

Whary MT; Danon SJ; Feng Y; Ge Z; Sundina N; Ng V; Taylor NS; Rogers AB; Fox JG. 2006. Rapid onset of ulcerative typhlocolitis in B6.129P2-IL10tm1Cgn (IL-10-/-) mice infected with Helicobacter trogontum is associated with decreased colonization by altered Schaedler's flora. Infect Immun 74(12):6615-23. [PubMed: 16982822]  [MGI Ref ID J:115918]

Whary MT; Taylor NS; Feng Y; Ge Z; Muthupalani S; Versalovic J; Fox JG. 2011. Lactobacillus reuteri promotes Helicobacter hepaticus-associated typhlocolitis in gnotobiotic B6.129P2-IL-10(tm1Cgn) (IL-10(-/-) ) mice. Immunology 133(2):165-78. [PubMed: 21426337]  [MGI Ref ID J:173794]

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Wilson EH; Wille-Reece U; Dzierszinski F; Hunter CA. 2005. A critical role for IL-10 in limiting inflammation during toxoplasmic encephalitis. J Neuroimmunol 165(1-2):63-74. [PubMed: 16005735]  [MGI Ref ID J:112764]

Wilson MS; Elnekave E; Mentink-Kane MM; Hodges MG; Pesce JT; Ramalingam TR; Thompson RW; Kamanaka M; Flavell RA; Keane-Myers A; Cheever AW; Wynn TA. 2007. IL-13Ralpha2 and IL-10 coordinately suppress airway inflammation, airway-hyperreactivity, and fibrosis in mice. J Clin Invest 117(10):2941-51. [PubMed: 17885690]  [MGI Ref ID J:127527]

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Winstead CJ; Reilly CS; Moon JJ; Jenkins MK; Hamilton SE; Jameson SC; Way SS; Khoruts A. 2010. CD4(+)CD25(+)Foxp3(+) regulatory T cells optimize diversity of the conventional T cell repertoire during reconstitution from lymphopenia. J Immunol 184(9):4749-60. [PubMed: 20357265]  [MGI Ref ID J:160453]

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Wojciechowski W; Harris DP; Sprague F; Mousseau B; Makris M; Kusser K; Honjo T; Mohrs K; Mohrs M; Randall T; Lund FE. 2009. Cytokine-producing effector B cells regulate type 2 immunity to H. polygyrus. Immunity 30(3):421-33. [PubMed: 19249230]  [MGI Ref ID J:146768]

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Wynn TA; Morawetz R; Scharton-Kersten T; Hieny S; Morse HC 3rd ; Kuhn R ; Muller W ; Cheever AW ; Sher A. 1997. Analysis of granuloma formation in double cytokine-deficient mice reveals a central role for IL-10 in polarizing both T helper cell 1- and T helper cell 2-type cytokine responses in vivo. J Immunol 159(10):5014-23. [PubMed: 9366429]  [MGI Ref ID J:44069]

Xavier MN; Winter MG; Spees AM; Nguyen K; Atluri VL; Silva TM; Baumler AJ; Muller W; Santos RL; Tsolis RM. 2013. CD4+ T cell-derived IL-10 promotes Brucella abortus persistence via modulation of macrophage function. PLoS Pathog 9(6):e1003454. [PubMed: 23818855]  [MGI Ref ID J:213384]

Xia ZW; Xu LQ; Zhong WW; Wei JJ; Li NL; Shao J; Li YZ; Yu SC; Zhang ZL. 2007. Heme oxygenase-1 attenuates ovalbumin-induced airway inflammation by up-regulation of foxp3 T-regulatory cells, interleukin-10, and membrane-bound transforming growth factor- 1. Am J Pathol 171(6):1904-14. [PubMed: 17991714]  [MGI Ref ID J:129098]

Xu L; Yin W; Sun R; Wei H; Tian Z. 2013. Liver type I regulatory T cells suppress germinal center formation in HBV-tolerant mice. Proc Natl Acad Sci U S A 110(42):16993-8. [PubMed: 24089450]  [MGI Ref ID J:201989]

Xue X; Feng T; Yao S; Wolf KJ; Liu CG; Liu X; Elson CO; Cong Y. 2011. Microbiota downregulates dendritic cell expression of miR-10a, which targets IL-12/IL-23p40. J Immunol 187(11):5879-86. [PubMed: 22068236]  [MGI Ref ID J:179678]

Yan F; John SK; Wilson G; Jones DS; Washington MK; Polk DB. 2004. Kinase suppressor of Ras-1 protects intestinal epithelium from cytokine-mediated apoptosis during inflammation. J Clin Invest 114(9):1272-80. [PubMed: 15520859]  [MGI Ref ID J:94534]

Yanaba K; Bouaziz JD; Haas KM; Poe JC; Fujimoto M; Tedder TF. 2008. A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses. Immunity 28(5):639-50. [PubMed: 18482568]  [MGI Ref ID J:136340]

Yanaba K; Bouaziz JD; Matsushita T; Tsubata T; Tedder TF. 2009. The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals. J Immunol 182(12):7459-72. [PubMed: 19494269]  [MGI Ref ID J:149301]

Yanaba K; Kamata M; Ishiura N; Shibata S; Asano Y; Tada Y; Sugaya M; Kadono T; Tedder TF; Sato S. 2013. Regulatory B cells suppress imiquimod-induced, psoriasis-like skin inflammation. J Leukoc Biol 94(4):563-73. [PubMed: 23630391]  [MGI Ref ID J:202646]

Yang F; Dong A; Mueller P; Caicedo J; Sutton AM; Odetunde J; Barrick CJ; Klyachkin YM; Abdel-Latif A; Smyth SS. 2012. Coronary artery remodeling in a model of left ventricular pressure overload is influenced by platelets and inflammatory cells. PLoS One 7(8):e40196. [PubMed: 22916095]  [MGI Ref ID J:190055]

Yang HT; Wang Y; Zhao X; Demissie E; Papoutsopoulou S; Mambole A; O'Garra A; Tomczak MF; Erdman SE; Fox JG; Ley SC; Horwitz BH. 2011. NF-(kappa)B1 inhibits TLR-induced IFN-(beta) production in macrophages through TPL-2-dependent ERK activation. J Immunol 186(4):1989-96. [PubMed: 21217011]  [MGI Ref ID J:169175]

Yang I; Eibach D; Kops F; Brenneke B; Woltemate S; Schulze J; Bleich A; Gruber AD; Muthupalani S; Fox JG; Josenhans C; Suerbaum S. 2013. Intestinal microbiota composition of interleukin-10 deficient C57BL/6J mice and susceptibility to Helicobacter hepaticus-induced colitis. PLoS One 8(8):e70783. [PubMed: 23951007]  [MGI Ref ID J:204929]

Yang M; Deng J; Liu Y; Ko KH; Wang X; Jiao Z; Wang S; Hua Z; Sun L; Srivastava G; Lau CS; Cao X; Lu L. 2012. IL-10-Producing Regulatory B10 Cells Ameliorate Collagen-Induced Arthritis via Suppressing Th17 Cell Generation. Am J Pathol 180(6):2375-85. [PubMed: 22538089]  [MGI Ref ID J:184805]

Yang M; Sun L; Wang S; Ko KH; Xu H; Zheng BJ; Cao X; Lu L. 2010. Novel function of B cell-activating factor in the induction of IL-10-producing regulatory B cells. J Immunol 184(7):3321-5. [PubMed: 20208006]  [MGI Ref ID J:160064]

Yang X; Wang S; Fan Y; Han X. 2000. IL-10 deficiency prevents IL-5 overproduction and eosinophilic inflammation in a murine model of asthma-like reaction. Eur J Immunol 30(2):382-91. [PubMed: 10671193]  [MGI Ref ID J:60381]

Yang Z; Zhang X; Darrah PA; Mosser DM. 2010. The Regulation of Th1 Responses by the p38 MAPK. J Immunol 185(10):6205-13. [PubMed: 20937847]  [MGI Ref ID J:165637]

Yao Y; Li W; Kaplan MH; Chang CH. 2005. Interleukin (IL)-4 inhibits IL-10 to promote IL-12 production by dendritic cells. J Exp Med 201(12):1899-903. [PubMed: 15967820]  [MGI Ref ID J:99206]

Yen D; Cheung J; Scheerens H; Poulet F; McClanahan T; McKenzie B; Kleinschek MA; Owyang A; Mattson J; Blumenschein W; Murphy E; Sathe M; Cua DJ; Kastelein RA; Rennick D. 2006. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J Clin Invest 116(5):1310-6. [PubMed: 16670770]  [MGI Ref ID J:108946]

Yin S; Wang H; Park O; Wei W; Shen J; Gao B. 2011. Enhanced Liver Regeneration in IL-10-Deficient Mice after Partial Hepatectomy via Stimulating Inflammatory Response and Activating Hepatocyte STAT3. Am J Pathol 178(4):1614-21. [PubMed: 21435447]  [MGI Ref ID J:169853]

Yin Z; Bahtiyar G; Zhang N; Liu L; Zhu P; Robert ME; McNiff J; Madaio MP; Craft J. 2002. IL-10 regulates murine lupus. J Immunol 169(4):2148-55. [PubMed: 12165544]  [MGI Ref ID J:78239]

Yoshizaki A; Miyagaki T; DiLillo DJ; Matsushita T; Horikawa M; Kountikov EI; Spolski R; Poe JC; Leonard WJ; Tedder TF. 2012. Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions. Nature 491(7423):264-8. [PubMed: 23064231]  [MGI Ref ID J:189218]

Young A; Linehan E; Hams E; O'Hara Hall AC; McClurg A; Johnston JA; Hunter CA; Fallon PG; Fitzgerald DC. 2012. Cutting edge: suppression of GM-CSF expression in murine and human T cells by IL-27. J Immunol 189(5):2079-83. [PubMed: 22837488]  [MGI Ref ID J:189868]

Zediak VP; Hunter CA. 2003. IL-10 fails to inhibit the production of IL-18 in response to inflammatory stimuli. Cytokine 21(2):84-90. [PubMed: 12670447]  [MGI Ref ID J:128186]

Zemse SM; Chiao CW; Hilgers RH; Webb RC. 2010. Interleukin-10 inhibits the in vivo and in vitro adverse effects of TNF-{alpha} on the endothelium of murine aorta. Am J Physiol Heart Circ Physiol :. [PubMed: 20639218]  [MGI Ref ID J:162772]

Zhang B; Maris CH; Foell J; Whitmire J; Niu L; Song J; Kwon BS; Vella AT; Ahmed R; Jacob J; Mittler RS. 2007. Immune suppression or enhancement by CD137 T cell costimulation during acute viral infection is time dependent. J Clin Invest 117(10):3029-41. [PubMed: 17853940]  [MGI Ref ID J:127406]

Zhang L; Yuan S; Cheng G; Guo B. 2011. Type I IFN promotes IL-10 production from T cells to suppress Th17 cells and Th17-associated autoimmune inflammation. PLoS One 6(12):e28432. [PubMed: 22163016]  [MGI Ref ID J:182267]

Zhang N; Schroppel B; Lal G; Jakubzick C; Mao X; Chen D; Yin N; Jessberger R; Ochando JC; Ding Y; Bromberg JS. 2009. Regulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune response. Immunity 30(3):458-69. [PubMed: 19303390]  [MGI Ref ID J:147032]

Zhang R; Li Q; Chuang PY; Lu G; Liu R; Yang J; Peng L; Dai Y; Zheng Z; Qi CF; He JC; Xiong H. 2013. Regulation of pathogenic th17 cell differentiation by IL-10 in the development of glomerulonephritis. Am J Pathol 183(2):402-12. [PubMed: 23747510]  [MGI Ref ID J:198724]

Zhang R; Li Y; Beck PL; McCafferty DM. 2007. Toll-like receptor 4 regulates colitis-associated adenocarcinoma development in interleukin-10-deficient (IL-10(-/-)) mice. Biochem Soc Trans 35(Pt 5):1375-6. [PubMed: 17956355]  [MGI Ref ID J:131228]

Zhang R; Ma A; Urbanski SJ; McCafferty DM. 2007. Induction of inducible nitric oxide synthase: a protective mechanism in colitis-induced adenocarcinoma. Carcinogenesis 28(5):1122-30. [PubMed: 17116728]  [MGI Ref ID J:121056]

Zhang X; Deriaud E; Jiao X; Braun D; Leclerc C; Lo-Man R. 2007. Type I interferons protect neonates from acute inflammation through interleukin 10-producing B cells. J Exp Med 204(5):1107-18. [PubMed: 17485512]  [MGI Ref ID J:125728]

Zhang X; Hester SE; Kennett MJ; Karanikas AT; Bendor L; Place DE; Harvill ET. 2011. Interleukin-1 receptor signaling is required to overcome the effects of pertussis toxin and for efficient infection- or vaccination-induced immunity against Bordetella pertussis. Infect Immun 79(1):527-41. [PubMed: 20974829]  [MGI Ref ID J:167554]

Zhao J; de Vera J; Narushima S; Beck EX; Palencia S; Shinkawa P; Kim KA; Liu Y; Levy MD; Berg DJ; Abo A; Funk WD. 2007. R-spondin1, a novel intestinotrophic mitogen, ameliorates experimental colitis in mice. Gastroenterology 132(4):1331-43. [PubMed: 17408649]  [MGI Ref ID J:203619]

Zhao Z; Ciric B; Yu S; Zhang GX; Rostami A. 2010. Targeting ganglioside epitope 3G11 on the surface of CD4+ T cells suppresses EAE by altering the Treg/Th17 cell balance. Int Immunol 22(10):817-26. [PubMed: 20679513]  [MGI Ref ID J:164321]

Zhong J; Deaciuc IV; Burikhanov R; de Villiers WJ. 2006. Lipopolysaccharide-induced liver apoptosis is increased in interleukin-10 knockout mice. Biochim Biophys Acta 1762(4):468-77. [PubMed: 16497487]  [MGI Ref ID J:110238]

Zhong Y; Cantwell A; Dube PH. 2010. Transforming growth factor beta and CD25 are important for controlling systemic dissemination following Yersinia enterocolitica infection of the gut. Infect Immun 78(9):3716-25. [PubMed: 20584975]  [MGI Ref ID J:163014]

Zhou D; Collins CA; Wu P; Brown EJ. 2010. Protein tyrosine phosphatase SHP-1 positively regulates TLR-induced IL-12p40 production in macrophages through inhibition of phosphatidylinositol 3-kinase. J Leukoc Biol 87(5):845-55. [PubMed: 20145200]  [MGI Ref ID J:160352]

Zhou F; Ciric B; Li H; Yan Y; Li K; Cullimore M; Lauretti E; Gonnella P; Zhang GX; Rostami A. 2012. IL-10 deficiency blocks the ability of LPS to regulate expression of tolerance-related molecules on dendritic cells. Eur J Immunol 42(6):1449-58. [PubMed: 22622800]  [MGI Ref ID J:187763]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

Pricing for USA, Canada and Mexico shipping destinations View International Pricing


Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2625.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $1725.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing


Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3412.50
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $2242.50

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

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Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

General Supply Notes

Control Information

   None Available
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice
Surgical and Preconditioning Services
JAX® Services
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Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
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Terms of Use

Terms of Use

General Terms and Conditions

For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries regarding Terms of Use

Contracts Administration


JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty


In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.