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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Type Congenic; Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Homozygote x Homozygote (Female x Male) 22-AUG-06 Species laboratory mouse Generation N10+N1F13 (29-JUN-11)
Generation DefinitionsDonating Investigator Susumu Tonegawa, Massachusetts Institute of Technology Description
Mice homozygous for the transgenic insert are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. These transgenic mice express the Cre recombinase under the control of the mouse calcium/calmodulin-dependent protein kinase II alpha promoter. Cre recombinase expression is detected in the forebrain, specifically to the CA1 pyramidal cell layer in the hippocampus. When crossed with a strain containing loxP site flanked sequence of interest, Cre-mediated recombination occurs in the pyramidal cell layer.Development
A transgenic construct containing a 8.5 Kb sequence encoding the mouse calcium/calmodulin-dependent protein kinase II alpha promoter, sequence encoding Cre recombinase, and SV40 polyadenylation site sequence was injected into fertilized BCF1 eggs. The resulting male transgenic mice were bred to C57BL/6 mice, and then backcrossed to C57BL/6 mice for 10 generations.A 32 SNP (single nucleotide polymorphism) panel analysis, with 27 markers covering all 19 chromosomes and the X chromosome, as well as 5 markers that distinguish between the C57BL/6J and C57BL/6N substrains, was performed on the rederived living colony at The Jackson Laboratory Repository. While the 27 markers throughout the genome suggested a C57BL/6 genetic background, 4 of 5 markers that determine C57BL/6J from C57BL/6N were found to be segregating. These data suggest the mice sent to The Jackson Laboratory Repository were on a mixed C57BL/6J ; C57BL/6N genetic background.
Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of Camk2a
016198 129S6.Cg-Tg(Camk2a-tTA)1Mmay/JlwsJ 002362 B6.129P2-Camk2atm1Sva/J 007574 B6.Cg-Tg(Camk2a-Crebbp*)1364Tabe/J 005855 B6.Cg-Tg(Camk2a-Prkaca)426Tabe/J 007004 B6.Cg-Tg(Camk2a-tTA)1Mmay/DboJ 012362 B6;129S6-Tg(Camk2a-cre/ERT2)1Aibs/J 003010 B6;CBA-Tg(Camk2a-tTA)1Mmay/J 004995 C3H-Tg(Camk2a-Creb1/ESR1)3Sva/J 006575 C57BL/6-Camk2atm1Vyb/J 013760 C57BL/6-Tg(Camk2a-AIDPak)21Stl/J 006579 C57BL/6-Tg(Camk2a-Bdnf)A9Stl/J 005087 C57BL/6-Tg(Camk2a-IDE)1Selk/J 005086 C57BL/6-Tg(Camk2a-MME)3Selk/J 008833 C57BL/6-Tg(Camk2a-UBB)3413-1Fwvl/J 010712 C57BL/6-Tg(Camk2a-tTA)1Stl/J 008716 FVB/N-Tg(Myh6-AIP/PLN*)46Jded/J 015838 STOCK Tg(Camk2a-tTA)1Mmay Tg(tetO-ABL1*P242E*P249E)CPdav/J View Strains carrying other alleles of Camk2a (17 strains)
Additional Web Information
Genetic Quality Control Annual Report
Introduction to Cre-lox technology
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
cre relatedDevelopmental Biology Research
Internal/Organ Defects
brain
Neurobiology Research
Channel and Transporter Defects
Cortical Defects
Cre-lox System
Cre Recombinase expression in neural tissue
Neurotransmitter Receptor and Synaptic Vesicle Defects
Research Tools
Cre-lox System
Cre Recombinase Expression
Developmental Biology Research
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Neurobiology Research
Research Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Tg(Camk2a-cre)T29-1Stl | ||
|---|---|---|---|
| Allele Name | transgene insertion T29-1, Susumu Tonegawa | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) | CaMKIIalpha-cre; Cre; T29-1; | ||
| Mutation Made By | Susumu Tonegawa, Massachusetts Institute of Technology | ||
| Strain of Origin | (C57BL x BALB/c)F1 | ||
| Site of Expression | forebrain; pyramidal cell layer | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Promoter | Camk2a, calcium/calmodulin-dependent protein kinase II alpha, mouse, laboratory | ||
| Gene Symbol and Name | Tg(Camk2a-cre)T29-1Stl, transgene insertion T29-1, Susumu Tonegawa | ||
| Chromosome | UN | ||
| Gene Common Name(s) | CaMKIIalpha-cre; Cre; | ||
| Driver Note | Camk2a | ||
| Molecular Note | This transgene directs the expression of Cre recombinase under the control of the alpha subunit of the calcium/calmodulin-dependent protein kinase II promoter. Cre recombinase activity was detected in the CA1 region of the hippocampus. [MGI Ref ID J:66344] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Generic Cre Quantitative PCR, QPCR
Generic Cre, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Tsien JZ; Chen DF; Gerber D; Tom C; Mercer EH; Anderson DJ; Mayford M; Kandel ER; Tonegawa S. 1996. Subregion- and cell type-restricted gene knockout in mouse brain [see comments] Cell 87(7):1317-26. [PubMed: 8980237] [MGI Ref ID J:66344]
Additional References
Tg(Camk2a-cre)T29-1Stl relatedAlberi L; Liu S; Wang Y; Badie R; Smith-Hicks C; Wu J; Pierfelice TJ; Abazyan B; Mattson MP; Kuhl D; Pletnikov M; Worley PF; Gaiano N. 2011. Activity-induced Notch signaling in neurons requires Arc/Arg3.1 and is essential for synaptic plasticity in hippocampal networks. Neuron 69(3):437-44. [PubMed: 21315255] [MGI Ref ID J:174749]
Bongmba OY; Martinez LA; Elhardt ME; Butler K; Tejada-Simon MV. 2011. Modulation of dendritic spines and synaptic function by Rac1: A possible link to Fragile X syndrome pathology. Brain Res 1399:79-95. [PubMed: 21645877] [MGI Ref ID J:174070]
Borgesius NZ; de Waard MC; van der Pluijm I; Omrani A; Zondag GC; van der Horst GT; Melton DW; Hoeijmakers JH; Jaarsma D; Elgersma Y. 2011. Accelerated age-related cognitive decline and neurodegeneration, caused by deficient DNA repair. J Neurosci 31(35):12543-53. [PubMed: 21880916] [MGI Ref ID J:176221]
Bozdagi O; Wang XB; Nikitczuk JS; Anderson TR; Bloss EB; Radice GL; Zhou Q; Benson DL; Huntley GW. 2010. Persistence of coordinated long-term potentiation and dendritic spine enlargement at mature hippocampal CA1 synapses requires N-cadherin. J Neurosci 30(30):9984-9. [PubMed: 20668183] [MGI Ref ID J:162856]
Brigman JL; Wright T; Talani G; Prasad-Mulcare S; Jinde S; Seabold GK; Mathur P; Davis MI; Bock R; Gustin RM; Colbran RJ; Alvarez VA; Nakazawa K; Delpire E; Lovinger DM; Holmes A. 2010. Loss of GluN2B-containing NMDA receptors in CA1 hippocampus and cortex impairs long-term depression, reduces dendritic spine density, and disrupts learning. J Neurosci 30(13):4590-600. [PubMed: 20357110] [MGI Ref ID J:159387]
Carlisle HJ; Luong TN; Medina-Marino A; Schenker L; Khorosheva E; Indersmitten T; Gunapala KM; Steele AD; O'Dell TJ; Patterson PH; Kennedy MB. 2011. Deletion of Densin-180 Results in Abnormal Behaviors Associated with Mental Illness and Reduces mGluR5 and DISC1 in the Postsynaptic Density Fraction. J Neurosci 31(45):16194-207. [PubMed: 22072671] [MGI Ref ID J:177836]
Chan CS; Levenson JM; Mukhopadhyay PS; Zong L; Bradley A; Sweatt JD; Davis RL. 2007. Alpha3-integrins are required for hippocampal long-term potentiation and working memory. Learn Mem 14(9):606-15. [PubMed: 17848500] [MGI Ref ID J:147820]
Chan CS; Weeber EJ; Zong L; Fuchs E; Sweatt JD; Davis RL. 2006. Beta1-integrins are required for hippocampal AMPA receptor-dependent synaptic transmission, synaptic plasticity, and working memory. J Neurosci 26(1):223-32. [PubMed: 16399691] [MGI Ref ID J:104150]
Chao HT; Chen H; Samaco RC; Xue M; Chahrour M; Yoo J; Neul JL; Gong S; Lu HC; Heintz N; Ekker M; Rubenstein JL; Noebels JL; Rosenmund C; Zoghbi HY. 2010. Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes. Nature 468(7321):263-9. [PubMed: 21068835] [MGI Ref ID J:166851]
Chen Q; Nakajima A; Choi SH; Xiong X; Sisodia SS; Tang YP. 2008. Adult neurogenesis is functionally associated with AD-like neurodegeneration. Neurobiol Dis 29(2):316-26. [PubMed: 17980611] [MGI Ref ID J:141456]
Cui Z; Wang H; Tan Y; Zaia KA; Zhang S; Tsien JZ. 2004. Inducible and reversible NR1 knockout reveals crucial role of the NMDA receptor in preserving remote memories in the brain. Neuron 41(5):781-93. [PubMed: 15003177] [MGI Ref ID J:88689]
Dong S; Li C; Wu P; Tsien JZ; Hu Y. 2007. Environment enrichment rescues the neurodegenerative phenotypes in presenilins-deficient mice. Eur J Neurosci 26(1):101-12. [PubMed: 17614943] [MGI Ref ID J:125930]
Feng R; Rampon C; Tang YP; Shrom D; Jin J; Kyin M; Sopher B; Martin GM; Kim SH; Langdon RB; Sisodia SS; Tsien JZ. 2001. Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces. Neuron 32(5):911-26. [PubMed: 11738035] [MGI Ref ID J:73252]
Feng R; Wang H; Wang J; Shrom D; Zeng X; Tsien JZ. 2004. Forebrain degeneration and ventricle enlargement caused by double knockout of Alzheimer's presenilin-1 and presenilin-2. Proc Natl Acad Sci U S A 101(21):8162-7. [PubMed: 15148382] [MGI Ref ID J:90685]
Ferguson C; Hardy SL; Werner DF; Hileman SM; Delorey TM; Homanics GE. 2007. New insight into the role of the beta3 subunit of the GABAA-R in development, behavior, body weight regulation, and anesthesia revealed by conditional gene knockout. BMC Neurosci 8:85. [PubMed: 17927825] [MGI Ref ID J:127877]
Fukaya M; Kato A; Lovett C; Tonegawa S; Watanabe M. 2003. Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice. Proc Natl Acad Sci U S A 100(8):4855-60. [PubMed: 12676993] [MGI Ref ID J:83403]
Genetic Resource Sciences at The Jackson Laboratory. 2008. Expression/Specificity patterns of Cre transgenes MGI Direct Data Submission :. [MGI Ref ID J:137887]
Gould TD; O'Donnell KC; Picchini AM; Dow ER; Chen G; Manji HK. 2008. Generation and behavioral characterization of beta-catenin forebrain-specific conditional knock-out mice. Behav Brain Res 189(1):117-25. [PubMed: 18299155] [MGI Ref ID J:132769]
He M; Liu Y; Wang X; Zhang MQ; Hannon GJ; Huang ZJ. 2012. Cell-Type-Based Analysis of MicroRNA Profiles in the Mouse Brain. Neuron 73(1):35-48. [PubMed: 22243745] [MGI Ref ID J:179351]
Huang Z; Shimazu K; Woo NH; Zang K; Muller U; Lu B; Reichardt LF. 2006. Distinct roles of the beta 1-class integrins at the developing and the mature hippocampal excitatory synapse. J Neurosci 26(43):11208-19. [PubMed: 17065460] [MGI Ref ID J:114964]
Ivanova E; Hwang GS; Pan ZH. 2010. Characterization of transgenic mouse lines expressing Cre recombinase in the retina. Neuroscience 165(1):233-43. [PubMed: 19837136] [MGI Ref ID J:158209]
Jiang Z; Belforte JE; Lu Y; Yabe Y; Pickel J; Smith CB; Je HS; Lu B; Nakazawa K. 2010. eIF2alpha Phosphorylation-dependent translation in CA1 pyramidal cells impairs hippocampal memory consolidation without affecting general translation. J Neurosci 30(7):2582-94. [PubMed: 20164343] [MGI Ref ID J:157834]
Johnson AW; Crombag HS; Smith DR; Ramanan N. 2011. Effects of serum response factor (SRF) deletion on conditioned reinforcement. Behav Brain Res 220(2):312-8. [PubMed: 21329726] [MGI Ref ID J:171461]
Kallhoff-Munoz V; Hu L; Chen X; Pautler RG; Zheng H. 2008. Genetic dissection of gamma-secretase-dependent and -independent functions of presenilin in regulating neuronal cell cycle and cell death. J Neurosci 28(44):11421-31. [PubMed: 18971484] [MGI Ref ID J:143253]
Kelleher RJ 3rd; Govindarajan A; Jung HY; Kang H; Tonegawa S. 2004. Translational control by MAPK signaling in long-term synaptic plasticity and memory. Cell 116(3):467-79. [PubMed: 15016380] [MGI Ref ID J:88546]
Liu Q; Trotter J; Zhang J; Peters MM; Cheng H; Bao J; Han X; Weeber EJ; Bu G. 2010. Neuronal LRP1 knockout in adult mice leads to impaired brain lipid metabolism and progressive, age-dependent synapse loss and neurodegeneration. J Neurosci 30(50):17068-78. [PubMed: 21159977] [MGI Ref ID J:167724]
Liu Q; Zerbinatti CV; Zhang J; Hoe HS; Wang B; Cole SL; Herz J; Muglia L; Bu G. 2007. Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1. Neuron 56(1):66-78. [PubMed: 17920016] [MGI Ref ID J:126954]
Madisen L; Zwingman TA; Sunkin SM; Oh SW; Zariwala HA; Gu H; Ng LL; Palmiter RD; Hawrylycz MJ; Jones AR; Lein ES; Zeng H. 2010. A robust and high-throughput Cre reporting and characterization system for the whole mouse brain. Nat Neurosci 13(1):133-40. [PubMed: 20023653] [MGI Ref ID J:155793]
Mirnics ZK; Yan C; Portugal C; Kim TW; Saragovi HU; Sisodia SS; Mirnics K; Schor NF. 2005. P75 neurotrophin receptor regulates expression of neural cell adhesion molecule 1. Neurobiol Dis 20(3):969-85. [PubMed: 16006137] [MGI Ref ID J:104654]
Rajadhyaksha AM; Ra S; Kishinevsky S; Lee AS; Romanienko P; DuBoff M; Yang C; Zupan B; Byrne M; Daruwalla ZR; Mark W; Kosofsky BE; Toth M; Higgins JJ. 2012. Behavioral characterization of cereblon forebrain-specific conditional null mice: a model for human non-syndromic intellectual disability. Behav Brain Res 226(2):428-34. [PubMed: 21995942] [MGI Ref ID J:179427]
Ramanan N; Shen Y; Sarsfield S; Lemberger T; Schutz G; Linden DJ; Ginty DD. 2005. SRF mediates activity-induced gene expression and synaptic plasticity but not neuronal viability. Nat Neurosci 8(6):759-67. [PubMed: 15880109] [MGI Ref ID J:99232]
Rampon C; Tang YP; Goodhouse J; Shimizu E; Kyin M; Tsien JZ. 2000. Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice [see comments] Nat Neurosci 3(3):238-44. [PubMed: 10700255] [MGI Ref ID J:60730]
Rondi-Reig L; Libbey M; Eichenbaum H; Tonegawa S. 2001. CA1-specific N-methyl-D-aspartate receptor knockout mice are deficient in solving a nonspatial transverse patterning task. Proc Natl Acad Sci U S A 98(6):3543-8. [PubMed: 11248114] [MGI Ref ID J:68059]
Schweizer C; Balsiger S; Bluethmann H; Mansuy IM; Fritschy JM; Mohler H; Luscher B. 2003. The gamma2 subunit of GABA(A) receptors is required for maintenance of receptors at mature synapses. Mol Cell Neurosci 24(2):442-50. [PubMed: 14572465] [MGI Ref ID J:86221]
Shimizu E; Tang YP; Rampon C; Tsien JZ. 2000. NMDA receptor-dependent synaptic reinforcement as a crucial process for memory consolidation. Science 290(5494):1170-4. [PubMed: 11073458] [MGI Ref ID J:77659]
Skvorak K; Vissel B; Homanics GE. 2006. Production of conditional point mutant knockin mice. Genesis 44(7):345-53. [PubMed: 16832820] [MGI Ref ID J:110982]
Tsien JZ; Huerta PT; Tonegawa S. 1996. The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory [see comments] Cell 87(7):1327-38. [PubMed: 8980238] [MGI Ref ID J:37457]
Valor LM; Pulopulos MM; Jimenez-Minchan M; Olivares R; Lutz B; Barco A. 2011. Ablation of CBP in Forebrain Principal Neurons Causes Modest Memory and Transcriptional Defects and a Dramatic Reduction of Histone Acetylation But Does Not Affect Cell Viability. J Neurosci 31(5):1652-63. [PubMed: 21289174] [MGI Ref ID J:168984]
Wu P; Shen Q; Dong S; Xu Z; Tsien JZ; Hu Y. 2008. Calorie restriction ameliorates neurodegenerative phenotypes in forebrain-specific presenilin-1 and presenilin-2 double knockout mice. Neurobiol Aging 29(10):1502-11. [PubMed: 17499883] [MGI Ref ID J:140910]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX11
Colony Maintenance
Breeding & Husbandry When maintaining a live colony, these mice are bred as homozygotes. Mating System Homozygote x Homozygote (Female x Male) 22-AUG-06 Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Live Mice
Price (US dollars $) Gender Genotypes Provided Individual Mouse $225.00 Female or Male Homozygous for Tg(Camk2a-cre)T29-1Stl
Pairs /Price (US dollars $) Pair Genotype $450.00 Homozygous for Tg(Camk2a-cre)T29-1Stl x Homozygous for Tg(Camk2a-cre)T29-1Stl Standard Supply
Repository-Live. The Repository Strains represent an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. We treat orders for these strains as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
| Pricing for International shipping destinations |
|
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Live Mice
Price (US dollars $) Gender Genotypes Provided Individual Mouse $292.50 Female or Male Homozygous for Tg(Camk2a-cre)T29-1Stl
Pairs /Price (US dollars $) Pair Genotype $585.00 Homozygous for Tg(Camk2a-cre)T29-1Stl x Homozygous for Tg(Camk2a-cre)T29-1Stl Standard Supply
Repository-Live. The Repository Strains represent an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. We treat orders for these strains as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
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Standard Supply
Repository-Live. The Repository Strains represent an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. We treat orders for these strains as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
General Supply Notes
- This strain is included in the Induced Mutant Resource Colony collection.
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
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