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Common Names: T29-1;    
These CaMKIIalpha-cre T29-1 transgenic mice have the mouse calcium/calmodulin-dependent protein kinase II alpha (Camk2a) promoter driving Cre recombinase expression in the forebrain, specifically to the CA1 pyramidal cell layer in the hippocampus.


Strain Information

Type Congenic; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
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Additional information on Congenic nomenclature.
Mating SystemHomozygote x Homozygote         (Female x Male)   22-AUG-06
Specieslaboratory mouse
GenerationN10+N2F5 (12-DEC-13)
Generation Definitions
Donating InvestigatorDr. Susumu Tonegawa,   Massachusetts Institute of Technology

Mice homozygous for the transgenic insert are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. These transgenic mice express the Cre recombinase under the control of the mouse calcium/calmodulin-dependent protein kinase II alpha promoter. Cre recombinase expression is detected in the forebrain, specifically to the CA1 pyramidal cell layer in the hippocampus. When crossed with a strain containing loxP site flanked sequence of interest, Cre-mediated recombination occurs in the pyramidal cell layer.

View cre expression characterization.

A transgenic construct containing a 8.5 kbp sequence encoding the mouse calcium/calmodulin-dependent protein kinase II alpha promoter, sequence encoding Cre recombinase, and SV40 polyadenylation site sequence was injected into fertilized BCF1 eggs. The resulting male transgenic mice were bred to C57BL/6 mice, and then backcrossed to C57BL/6 mice for 10 generations.

A 32 SNP (single nucleotide polymorphism) panel analysis, with 27 markers covering all 19 chromosomes and the X chromosome, as well as 5 markers that distinguish between the C57BL/6J and C57BL/6N substrains, was performed on the rederived living colony at The Jackson Laboratory Repository. While the 27 markers throughout the genome suggested a C57BL/6 genetic background, 4 of 5 markers that determine C57BL/6J from C57BL/6N were found to be segregating. These data suggest the mice sent to The Jackson Laboratory Repository were on a mixed C57BL/6J ; C57BL/6N genetic background.

Control Information

   000664 C57BL/6J
  Considerations for Choosing Controls

Related Strains

Strains carrying   Tg(Camk2a-cre)T29-1Stl allele
018966   B6N.Cg-Tg(Camk2a-cre)T29-1Stl/J
View Strains carrying   Tg(Camk2a-cre)T29-1Stl     (1 strain)

View Strains carrying other alleles of Camk2a     (25 strains)

Strains carrying other alleles of cre
004337   129(Cg)-Foxg1tm1(cre)Skm/J
008569   129-Alpltm1(cre)Nagy/J
005989   129;FVB-Tg(PTH-cre)4167Slib/J
007179   129S.Cg-Tg(UBC-cre/ERT2)1Ejb/J
007915   129S.FVB-Tg(Amh-cre)8815Reb/J
003328   129S/Sv-Tg(Prm-cre)58Og/J
026200   129S1.Cg-Tg(Vsx2-cre)2690Chow/J
004302   129S1/Sv-Hprttm1(cre)Mnn/J
022137   129S4.Cg-Tg(Wnt1-cre)2Sor/J
003960   129S6-Tg(Prnp-GFP/cre)1Blw/J
008523   129S6.Cg-Tg(NPHS2-cre)295Lbh/BroJ
009587   B6(129S4)-Et(icre)1402Rdav/J
009588   B6(129S4)-Et(icre)1470Rdav/J
009589   B6(129S4)-Et(icre)1555Rdav/J
009586   B6(129S4)-Et(icre)754Rdav/J
012687   B6(129S4)-Tg(SYN1-icre/mRFP1)9934Rdav/J
010774   B6(Cg)-Calb2tm1(cre)Zjh/J
017562   B6(Cg)-Cd8atm1.1(cre)Koni/J
012704   B6(Cg)-Crhtm1(cre)Zjh/J
018448   B6(Cg)-Foxn1tm3(cre)Nrm/J
026801   B6(Cg)-Ins1tm1.1(cre)Thor/J
016223   B6(Cg)-Tg(Phox2b-cre)3Jke/J
016829   B6(SJL)-Pou5f1tm1.1(cre/Esr1*)Yseg/J
016959   B6.129(Cg)-Foxp3tm4(YFP/cre)Ayr/J
023055   B6.129(Cg)-Krt12tm3(cre)Wwk/J
008320   B6.129-Leprtm2(cre)Rck/J
017526   B6.129-Nos1tm1(cre)Mgmj/J
005697   B6.129-Otx1tm4(cre)Asim/J
018938   B6.129-Tac2tm1.1(cre)Qima/J
017769   B6.129-Trpv1tm1(cre)Bbm/J
004146   B6.129-Tg(Pcp2-cre)2Mpin/J
008710   B6.129P2(129S4)-Hprttm10(Ple162-EGFP/cre)Ems/Mmjax
008877   B6.129P2(129S4)-Hprttm12(Ple177-EGFP/cre)Ems/Mmjax
009116   B6.129P2(129S4)-Hprttm16(Ple167-EGFP/cre)Ems/Mmjax
008709   B6.129P2(129S4)-Hprttm9(Ple178-EGFP/cre)Ems/Mmjax
006785   B6.129P2(C)-Cd19tm1(cre)Cgn/J
006084   B6.129P2(Cg)-Foxg1tm1(cre)Skm/J
010611   B6.129P2(Cg)-Ighg1tm1(IRES-cre)Cgn/J
007770   B6.129P2-Aicdatm1(cre)Mnz/J
004781   B6.129P2-Lyz2tm1(cre)Ifo/J
017320   B6.129P2-Pvalbtm1(cre)Arbr/J
017915   B6.129S(Cg)-Pgrtm1.1(cre)Shah/AndJ
013594   B6.129S-Atoh1tm5.1(Cre/PGR)Hzo/J
021794   B6.129S1(Cg)-Ascl3tm1.1(EGFP/cre)Ovi/J
024637   B6.129S1(SJL)-Nkx2-5tm2(cre)Rph/J
006600   B6.129S1-Mnx1tm4(cre)Tmj/J
005628   B6.129S2-Emx1tm1(cre)Krj/J
022510   B6.129S4-Gpr88tm1.1(cre/GFP)Rpa/J
017578   B6.129S4-Mcpt8tm1(cre)Lky/J
003755   B6.129S4-Meox2tm1(cre)Sor/J
007893   B6.129S4-Myf5tm3(cre)Sor/J
006878   B6.129S6-Taglntm2(cre)Yec/J
012839   B6.129X1(Cg)-Tnfrsf4tm2(cre)Nik/J
008712   B6.129X1-Twist2tm1.1(cre)Dor/J
006054   B6.C-Tg(CMV-cre)1Cgn/J
020811   B6.C-Tg(Pgk1-cre)1Lni/CrsJ
023530   B6.Cg-Avptm1.1(cre)Hze/J
013590   B6.Cg-Braftm1Mmcm Ptentm1Hwu Tg(Tyr-cre/ERT2)13Bos/BosJ
006230   B6.Cg-Cebpatm1Dgt Tg(Mx1-cre)1Cgn/J
012358   B6.Cg-Pvalbtm1.1(cre)Aibs/J
005622   B6.Cg-Shhtm1(EGFP/cre)Cjt/J
022762   B6.Cg-Zfp335tm1.2Caw Emx1tm1(cre)Krj/J
017346   B6.Cg-Tg(A930038C07Rik-cre)1Aibs/J
006149   B6.Cg-Tg(ACTA1-cre)79Jme/J
003574   B6.Cg-Tg(Alb-cre)21Mgn/J
006881   B6.Cg-Tg(Aqp2-cre)1Dek/J
011104   B6.Cg-Tg(Atoh1-cre)1Bfri/J
004682   B6.Cg-Tg(CAG-cre/Esr1*)5Amc/J
008520   B6.Cg-Tg(CD2-cre)4Kio/J
009350   B6.Cg-Tg(CDX2-cre)101Erf/J
009352   B6.Cg-Tg(CDX2-cre*)189Erf/J
027310   B6.Cg-Tg(Camk2a-cre)2Szi/J
027400   B6.Cg-Tg(Camk2a-cre)3Szi/J
022071   B6.Cg-Tg(Cd4-cre)1Cwi/BfluJ
012237   B6.Cg-Tg(Cdh16-cre)91Igr/J
006368   B6.Cg-Tg(Cr2-cre)3Cgn/J
008538   B6.Cg-Tg(Cspg4-cre/Esr1*)BAkik/J
006663   B6.Cg-Tg(Eno2-cre)39Jme/J
005069   B6.Cg-Tg(Fabp4-cre)1Rev/J
012712   B6.Cg-Tg(Fev-cre)1Esd/J
012849   B6.Cg-Tg(GFAP-cre/ERT2)505Fmv/J
012886   B6.Cg-Tg(Gfap-cre)73.12Mvs/J
024098   B6.Cg-Tg(Gfap-cre)77.6Mvs/2J
009642   B6.Cg-Tg(Gh1-cre)1Sac/J
024474   B6.Cg-Tg(Il9-cre)#Stck/J
003573   B6.Cg-Tg(Ins2-cre)25Mgn/J
008068   B6.Cg-Tg(Itgax-cre)1-1Reiz/J
008781   B6.Cg-Tg(Kap-cre)29066/2Sig/J
003802   B6.Cg-Tg(Lck-cre)548Jxm/J
006889   B6.Cg-Tg(Lck-cre)I540Jxm/J
012837   B6.Cg-Tg(Lck-icre)3779Nik/J
009643   B6.Cg-Tg(Lhb-cre)1Sac/J
008330   B6.Cg-Tg(Mc4r-cre)25Rck/J
003556   B6.Cg-Tg(Mx1-cre)1Cgn/J
007742   B6.Cg-Tg(Myh11-cre,-EGFP)2Mik/J
008205   B6.Cg-Tg(NPHS2-cre)295Lbh/J
003771   B6.Cg-Tg(Nes-cre)1Kln/J
010536   B6.Cg-Tg(Pcp2-cre)3555Jdhu/J
005975   B6.Cg-Tg(Plp1-cre/ERT)3Pop/J
008827   B6.Cg-Tg(Prdm1-cre)1Masu/J
005584   B6.Cg-Tg(Prrx1-cre)1Cjt/J
003967   B6.Cg-Tg(Rbp3-cre)528Jxm/J
021614   B6.Cg-Tg(S100A8-cre,-EGFP)1Ilw/J
008454   B6.Cg-Tg(Sox2-cre)1Amc/J
006361   B6.Cg-Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/J
003966   B6.Cg-Tg(Syn1-cre)671Jxm/J
017491   B6.Cg-Tg(Tagln-cre)1Her/J
004128   B6.Cg-Tg(Tek-cre)12Flv/J
008863   B6.Cg-Tg(Tek-cre)1Ywa/J
008601   B6.Cg-Tg(Th-cre)1Tmd/J
012328   B6.Cg-Tg(Tyr-cre/ERT2)13Bos/J
008085   B6.Cg-Tg(UBC-cre/ERT2)1Ejb/J
008610   B6.Cg-Tg(Vav1-cre)A2Kio/J
004586   B6.Cg-Tg(Vil-cre)997Gum/J
021504   B6.Cg-Tg(Vil1-cre)1000Gum/J
008735   B6.Cg-Tg(Wap-cre)11738Mam/JKnwJ
009614   B6.Cg-Tg(Wfs1-cre/ERT2)2Aibs/J
009107   B6.Cg-Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J
022501   B6.Cg-Tg(Wnt1-cre)2Sor/J
006234   B6.Cg-Tg(tetO-cre)1Jaw/J
016832   B6.FVB(129)-Tg(Alb1-cre)1Dlr/J
005657   B6.FVB(129)-Tg(Myh6-cre/Esr1*)1Jmk/J
024688   B6.FVB(129S)-Tg(Pax6-GFP/cre)1Rilm/J
006475   B6.FVB(129S4)-Tg(Ckmm-cre)5Khn/J
006451   B6.FVB(129X1)-Tg(Sim1-cre)1Lowl/J
006333   B6.FVB(Cg)-Tg(Neurog3-cre)C1Able/J
014643   B6.FVB-Tg(CMA1-cre)6Thhe/J
006137   B6.FVB-Tg(Cdh5-cre)7Mlia/J
018980   B6.FVB-Tg(Ddx4-cre)1Dcas/KnwJ
003724   B6.FVB-Tg(EIIa-cre)C5379Lmgd/J
011069   B6.FVB-Tg(Gh1-cre)bKnmn/J
011038   B6.FVB-Tg(Myh6-cre)2182Mds/J
014647   B6.FVB-Tg(Pdx1-cre)6Tuv/J
010714   B6.FVB-Tg(Pomc-cre)1Lowl/J
022791   B6.FVB-Tg(Rorc-cre)1Litt/J
017535   B6.FVB-Tg(Slc32a1-cre)2.1Hzo/FrkJ
017490   B6.FVB-Tg(Stra8-icre)1Reb/LguJ
024670   B6.FVB-Tg(Ucp1-cre)1Evdr/J
003394   B6.FVB-Tg(Zp3-cre)3Mrt/J
006660   B6.SJL-Slc6a3tm1.1(cre)Bkmn/J
003552   B6129-Tg(Wap-cre)11738Mam/J
023161   B6129S-Tg(Foxp3-EGFP/cre)1aJbs/J
021025   B6;129-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm1(tetO-cre)Haho/J
010529   B6;129-Myf5tm1(cre)Mrc/J
010528   B6;129-Myf6tm2(cre)Mrc/J
017525   B6;129-Ntstm1(cre)Mgmj/J
005549   B6;129-Pax3tm1(cre)Joe/J
017968   B6;129-Tg(Cdh5-cre)1Spe/J
024860   B6;129-Tg(Drd1-cre)120Mxu/Mmjax
010988   B6;129P-Cyp11a1tm1(GFP/cre)Pzg/J
008529   B6;129P-Tg(Neurog1-cre/ERT2)1Good/J
012601   B6;129P2-Lyve1tm1.1(EGFP/cre)Cys/J
006668   B6;129P2-Omptm4(cre)Mom/MomJ
008069   B6;129P2-Pvalbtm1(cre)Arbr/J
012373   B6;129S-Hoxb1tm1(cre)Og/J
024234   B6;129S-Oxttm1.1(cre)Dolsn/J
023526   B6;129S-Rorbtm1.1(cre)Hze/J
023527   B6;129S-Slc17a7tm1.1(cre)Hze/J
023525   B6;129S-Snap25tm2.1(cre)Hze/J
021877   B6;129S-Tac1tm1.1(cre)Hze/J
021878   B6;129S-Tac2tm1.1(cre)Hze/J
017685   B6;129S-Wisp3tm1(cre)Mawa/J
007001   B6;129S-Tg(UBC-cre/ERT2)1Ejb/J
009388   B6;129S1-Osr2tm2(cre)Jian/J
012463   B6;129S4-Foxd1tm1(GFP/cre)Amc/J
011105   B6;129S4-Olig1tm1(cre)Rth/J
006410   B6;129S6-Chattm2(cre)Lowl/J
009616   B6;C3-Tg(A930038C07Rik-cre)4Aibs/J
012433   B6;C3-Tg(ACTA1-rtTA,tetO-cre)102Monk/J
008844   B6;C3-Tg(Ctgf-cre)2Aibs/J
008839   B6;C3-Tg(Cyp39a1-cre)1Aibs/J
009117   B6;C3-Tg(Cyp39a1-cre)7Aibs/J
008848   B6;C3-Tg(Mybpc1-cre)2Aibs/J
009111   B6;C3-Tg(Scnn1a-cre)1Aibs/J
009112   B6;C3-Tg(Scnn1a-cre)2Aibs/J
009613   B6;C3-Tg(Scnn1a-cre)3Aibs/J
009103   B6;C3-Tg(Wfs1-cre/ERT2)3Aibs/J
025806   B6;CBA-Tg(Gsx2-cre)1Kess/J
026555   B6;CBA-Tg(Lhx6-cre)1Kess/J
025807   B6;CBA-Tg(Sox10-cre)1Wdr/J
024507   B6;CBA-Tg(Tbx21-cre)1Dlc/J
017494   B6;D-Tg(Tshz3-GFP/cre)43Amc/J
024926   B6;D2-Tg(Fshr-cre)1Ldu/J
003466   B6;D2-Tg(Sycp1-cre)4Min/J
014160   B6;DBA-Tg(S100b-EGFP/cre/ERT2)22Amc/J
014159   B6;DBA-Tg(Tmem100-EGFP/cre/ERT2)30Amc/J
015855   B6;DBA-Tg(Upk3a-GFP/cre/ERT2)26Amc/J
010803   B6;FVB-Tg(Adipoq-cre)1Evdr/J
018422   B6;FVB-Tg(Aicda-cre)1Rcas/J
023748   B6;FVB-Tg(Aldh1l1-cre)JD1884Gsat/J
011087   B6;FVB-Tg(Crh-cre)1Kres/J
008533   B6;FVB-Tg(Cspg4-cre)1Akik/J
003734   B6;FVB-Tg(GZMB-cre)1Jcb/J
015850   B6;SJL-Pde6b+ Tg(Rho-icre)1Ck/Boc
004426   B6;SJL-Tg(Cga-cre)3Sac/J
003554   B6;SJL-Tg(Col2a1-cre)1Bhr/J
017738   B6;SJL-Tg(Foxl1-cre)1Khk/J
005249   B6;SJL-Tg(Krt1-15-cre/PGR)22Cot/J
019893   B6;SJL-Tg(Tex101-icre)2Lzj/J
007252   B6Ei.129S4-Tg(Prm-cre)58Og/EiJ
025524   B6J.B6N(Cg)-Cx3cr1tm1.1(cre)Jung/J
018956   B6N.129P2(B6)-Lyz2tm1(cre)Ifo/J
018958   B6N.129P2-Cd19tm1(cre)Cgn/J
021077   B6N.129S1-Mrgprb4tm3(cre)And/J
018957   B6N.129S6(B6)-Chattm2(cre)Lowl/J
017911   B6N.129S6(Cg)-Esr1tm1.1(cre)And/J
019013   B6N.129S6(Cg)-Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
018974   B6N.B6-Tg(Nr4a1-EGFP/cre)820Khog/J
019021   B6N.Cg-Ccktm1.1(cre)Zjh/J
019022   B6N.Cg-Gad2tm2(cre)Zjh/J
018973   B6N.Cg-Ssttm2.1(cre)Zjh/J
018961   B6N.Cg-Tg(Alb-cre)21Mgn/J
019102   B6N.Cg-Tg(CAG-cre/Esr1*)5Amc/CjDswJ
018965   B6N.Cg-Tg(Fabp4-cre)1Rev/J
017310   B6N.Cg-Tg(Hsd17b1-icre/ERT2)3Casa/J
018960   B6N.Cg-Tg(Ins2-cre)25Mgn/J
018967   B6N.Cg-Tg(Itgax-cre)1-1Reiz/J
018964   B6N.Cg-Tg(KRT14-cre)1Amc/J
019103   B6N.Cg-Tg(Nes-cre)1Kln/CjDswJ
014094   B6N.Cg-Tg(Sox2-cre)1Amc/J
018968   B6N.Cg-Tg(Vav1-cre)A2Kio/J
018963   B6N.Cg-Tg(Vil-cre)997Gum/J
018972   B6N.FVB(B6)-Tg(Myh6-cre)2182Mds/J
019099   B6N.FVB-Tg(ACTB-cre)2Mrt/CjDswJ
019509   B6N.FVB-Tg(BGLAP-cre)1Clem/J
023047   B6N.FVB-Tg(Dmp1-cre)1Jqfe/BwdJ
017927   B6N.FVB-Tg(Mpz-cre)26Mes/J
003465   BALB/c-Tg(CMV-cre)1Cgn/J
012641   BALB/c-Tg(S100a4-cre)1Egn/YunkJ
010612   C.129P2(Cg)-Ighg1tm1(IRES-cre)Cgn/J
017353   C.129S4(B6)-Il13tm1(YFP/cre)Lky/J
017582   C.129S4(B6)-Mcpt8tm1(cre)Lky/J
004126   C.Cg-Cd19tm1(cre)Cgn Ighb/J
005673   C.Cg-Tg(Mx1-cre)1Cgn/J
006244   C.Cg-Tg(tetO-cre)1Jaw/J
009155   C57BL/6-Cldn6tm1(cre)Dkwu/J
017557   C57BL/6-Tg(BEST1-cre)1Jdun/J
027406   C57BL/6-Tg(CD2-cre)1Lov/J
016097   C57BL/6-Tg(Car1-cre)5Flt/J
011086   C57BL/6-Tg(Cck-cre)CKres/J
008766   C57BL/6-Tg(Cd8a-cre)1Itan/J
026828   C57BL/6-Tg(Cpa3-cre)4Glli/J
006474   C57BL/6-Tg(Grik4-cre)G32-4Stl/J
008314   C57BL/6-Tg(HBB-cre)12Kpe/J
008870   C57BL/6-Tg(Hspa2-cre)1Eddy/J
016261   C57BL/6-Tg(Nes-cre/ERT2)KEisc/J
012906   C57BL/6-Tg(Nes-cre/Esr1*)1Kuan/J
027205   C57BL/6-Tg(Nms-icre)20Ywa/J
016617   C57BL/6-Tg(Nr4a1-EGFP/cre)820Khog/J
020287   C57BL/6-Tg(Pbsn-cre/Esr1*)14Abch/J
013148   C57BL/6-Tg(Pdgfra-cre)1Clc/J
008535   C57BL/6-Tg(Pf4-cre)Q3Rsko/J
024034   C57BL/6-Tg(Pmch-cre)1Rck/J
016583   C57BL/6-Tg(Slc6a3-icre/ERT2)2Gloss/J
006888   C57BL/6-Tg(Zp3-cre)1Gwh/J
003651   C57BL/6-Tg(Zp3-cre)93Knw/J
021119   C57BL/6J-Tg(Dlx2-cre,-mCherry)4Grsr/GrsrJ
021423   C57BL/6J-Tg(Dlx2-cre,-mCherry)9Grsr/GrsrJ
007567   C57BL/6J-Tg(Itgax-cre,-EGFP)4097Ach/J
018895   C57BL/6J-Tg(Krt6,-cre,-Cerulean)1Grsr/Grsr
018896   C57BL/6J-Tg(Krt6,-cre,-Cerulean)2Grsr/Grsr
018898   C57BL/6J-Tg(Krt6,-cre,-Cerulean)4Grsr/Grsr
018899   C57BL/6J-Tg(Krt6,-cre,-Cerulean)5Grsr/Grsr
021582   C57BL/6J-Tg(Mchr1-cre)1Emf/J
008661   C57BL/6J-Tg(Nkx2-1-cre)2Sand/J
022883   C57BL/6J-Tg(Six6-cre)3Grsr/GrsrJ
022887   C57BL/6J-Tg(Six6-cre)7Grsr/GrsrJ
018754   C57BL/6J-Tg(Tbx22,-cre,-mCherry)1Grsr/GrsrJ
019363   C57BL/6J-Tg(Trp63,-cre,-Cerulean)10Grsr/Grsr
018792   C57BL/6J-Tg(Trp63,-cre,-Cerulean)4Grsr/GrsrJ
003650   C57BL/6J-Tg(Zp3-cre)82Knw/KnwJ
018151   C57BL/6N-Krt17tm1(cre,Cerulean)Murr/GrsrJ
023014   C57BL/6N-Tg(Calcrl,cre)4688Nkza/J
012686   C57BL/6N-Tg(Ppp1r2-cre)4127Nkza/J
016582   C57BL/6N-Tg(Slc32a1-icre/ERT2)3Gloss/J
026861   D2.129P2(B6)-Lyz2tm1(cre)Ifo/SjJ
026858   D2.129S4(B6)-Meox2tm1(cre)Sor/SjJ
026266   D2.B6-Tg(Zp3-cre)93Knw/SjJ
026852   D2.Cg-Tg(Gfap-cre)73.12Mvs/SjJ
024701   D2.Cg-Tg(Plp1-cre/ERT)3Pop/SjJ
026859   D2.Cg-Tg(Sox2-cre)1Amc/SjJ
026857   D2.FVB-Tg(GFAP-cre)25Mes/SjJ
026860   D2.FVB-Tg(Tek-cre)2352Rwng/SjJ
016833   FVB(Cg)-Tg(Alb1-cre)1Dlr/J
012929   FVB(Cg)-Tg(Dhh-cre)1Mejr/J
011034   FVB(Cg)-Tg(Ghrhr-cre)3242Lsk/J
006405   FVB-Tg(Ckmm-cre)5Khn/J
021024   FVB-Tg(Csf1r-icre)1Jwp/J
006954   FVB-Tg(Ddx4-cre)1Dcas/J
004600   FVB-Tg(GFAP-cre)25Mes/J
011037   FVB-Tg(Myh6-cre)2182Mds/J
006364   FVB-Tg(Nr5a1-cre)2Lowl/J
008537   FVB-Tg(Tek-cre)2352Rwng/J
019382   FVB.Cg-Myh9tm1.1Gac Tg(NPHS2-cre)295Lbh/Mmjax
014140   FVB.Cg-Myod1tm2.1(icre)Glh/J
006139   FVB.Cg-Tg(ACTA1-cre)79Jme/J
017595   FVB.Cg-Tg(CAG-cre/Esr1*)5Amc/J
006297   FVB.Cg-Tg(Eno2-cre)39Jme/J
018394   FVB.Cg-Tg(KRT5-cre/ERT2)2Ipc/JeldJ
008244   FVB.Cg-Tg(tetO-cre)1Jaw/J
003376   FVB/N-Tg(ACTB-cre)2Mrt/J
024384   FVB/N-Tg(AMELX-cre)A1Kul/J
003314   FVB/N-Tg(EIIa-cre)C5379Lmgd/J
025062   FVB/N-Tg(Figla-EGFP,-icre)ZP3Dean/Mmjax
017928   FVB/N-Tg(Mpz-cre)26Mes/J
025066   FVB/N-Tg(Mylpf-cre)3Kraj/Mmjax
006143   FVB/N-Tg(Thy1-cre)1Vln/J
003377   FVB/N-Tg(Zp3-cre)3Mrt/J
023325   FVB;B6-Tg(Pbsn-cre)20Fwan/J
019096   NOD.129P2(B6)-Lyz2tm1(cre)Ifo/NadlJ
023806   NOD.129P2(Cg)-Cd19tm1(cre)Cgn/J
013233   NOD.B6-Tg(Itgax-cre,-EGFP)4097Ach/J
013234   NOD.Cg-Tg(Cd4-cre)1Cwi/2AchJ
023972   NOD.Cg-Tg(Ins2-cre/ERT)1Dam/SbwJ
023203   NOD.Cg-Tg(Itgax-cre)1-1Reiz/PesaJ
005732   NOD.Cg-Tg(Lck-cre)548Jxm/AchJ
023973   NOD.Cg-Tg(Neurog3-cre)1Dam/SbwJ
013251   NOD.FVB-Tg(EIIa-cre)C5379Lmgd/J
008694   NOD/ShiLt-Tg(Foxp3-EGFP/cre)1cJbs/J
004986   NOD/ShiLt-Tg(Ins2-cre)3Lt/LtJ
003855   NOD/ShiLt-Tg(Ins2-cre)5Lt/LtJ
004987   NOD/ShiLt-Tg(Ins2-cre)6Lt/LtJ
012899   STOCK Agrptm1(cre)Lowl/J
026229   STOCK Akap12tm1Ihg Rb1tm2Brn Tg(Pbsn-cre)4Prb/J
012706   STOCK Ccktm1.1(cre)Zjh/J
010910   STOCK Corttm1(cre)Zjh/J
007916   STOCK En1tm2(cre)Wrst/J
008464   STOCK Foxa2tm2.1(cre/Esr1*)Moon/J
010802   STOCK Gad2tm2(cre)Zjh/J
018903   STOCK Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
023407   STOCK HhatTg(TFAP2A-cre)1Will/J
008876   STOCK Hprttm11(Ple176-EGFP/cre)Ems/Mmjax
016879   STOCK Il17atm1.1(icre)Stck/J
024242   STOCK Isl1tm1(cre)Sev/J
018976   STOCK Kdrtm1(cre)Sato/J
017701   STOCK Kiss1tm1.1(cre/EGFP)Stei/J
007022   STOCK Mnx1tm4(cre)Tmj Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
004192   STOCK Mttptm2Sgy Ldlrtm1Her Apobtm2Sgy Tg(Mx1-cre)1Cgn/J
023342   STOCK Myf5tm1(cre/Esr1*)Trdo/J
024713   STOCK Myl1tm1(cre)Sjb/J
014180   STOCK Myocdtm1(cre)Jomm/J
006953   STOCK Notch1tm3(cre)Rko/J
006677   STOCK Olfr151tm28(cre)Mom/MomJ
011103   STOCK Olig2tm2(TVA,cre)Rth/J
010530   STOCK Pax7tm1(cre)Mrc/J
019378   STOCK Ptf1atm2(cre/ESR1)Cvw/J
016963   STOCK Slc17a6tm2(cre)Lowl/J
016962   STOCK Slc32a1tm2(cre)Lowl/J
013044   STOCK Ssttm2.1(cre)Zjh/J
012719   STOCK Tgfb3tm1(cre)Vk/J
012620   STOCK Trp53tm1Brd Brca1tm1Aash Tg(LGB-cre)74Acl/J
008813   STOCK Trpa1tm2Kykw Tg(CAG-cre/Esr1*)5Amc/J
010908   STOCK Viptm1(cre)Zjh/J
010911   STOCK Wt1tm1(EGFP/cre)Wtp/J
008783   STOCK Tg(CAG-cre/Esr1*)5Amc Smn1tm3(SMN2/Smn1)Mrph Tg(SMN2*delta7)4299Ahmb Tg(SMN2)89Ahmb/J
004453   STOCK Tg(CAG-cre/Esr1*)5Amc/J
009615   STOCK Tg(Cartpt-cre)1Aibs/J
017336   STOCK Tg(Cd4-cre)1Cwi/BfluJ
005105   STOCK Tg(Chx10-EGFP/cre,-ALPP)2Clc/J
008861   STOCK Tg(Ela1-Cre/ERT2)1Stof/J
008852   STOCK Tg(En2-cre)22Alj/J
005938   STOCK Tg(Eno2-cre)39Jme/J
022763   STOCK Tg(Eno2-cre/ERT2)1Pohlk/J
011062   STOCK Tg(Gdf9-cre)5092Coo/J
012841   STOCK Tg(Ggt1-cre)M3Egn/J
021207   STOCK Tg(Gnrh1-cre)1Dlc/J
017981   STOCK Tg(Hoxb6-cre)#Mku/J
004692   STOCK Tg(Hoxb7-cre)13Amc/J
014600   STOCK Tg(I12b-cre/ERT2,-ALPP)37Fsh/J
008122   STOCK Tg(Ins2-cre/ERT)1Dam/J
004782   STOCK Tg(KRT14-cre)1Amc/J
005107   STOCK Tg(KRT14-cre/ERT)20Efu/J
008582   STOCK Tg(Kcnc2-Cre)K128Stl/LetJ
023426   STOCK Tg(Kiss1-cre)J2-4Cfe/J
017836   STOCK Tg(LGB-cre)74Acl/J
003551   STOCK Tg(MMTV-cre)1Mam/J
003553   STOCK Tg(MMTV-cre)4Mam/J
002527   STOCK Tg(Mx1-cre)1Cgn/J
009074   STOCK Tg(Myh6-cre)1Jmk/J
005650   STOCK Tg(Myh6-cre/Esr1*)1Jmk/J
009102   STOCK Tg(Nefh-cre)12Kul/J
002858   STOCK Tg(Nes-cre)1Wme/J
002859   STOCK Tg(Nes-cre)2Wme/J
012859   STOCK Tg(Neurog1-cre)1Jejo/J
005667   STOCK Tg(Neurog3-cre)C1Able/J
008119   STOCK Tg(Neurog3-cre/Esr1*)1Dam/J
012462   STOCK Tg(Nr5a1-cre)7Lowl/J
014158   STOCK Tg(Pax4-cre)1Dam/J
024578   STOCK Tg(Pax6-GFP/cre)1Rilm/J
006207   STOCK Tg(Pcp2-cre)1Amc/J
014099   STOCK Tg(Pmch-cre)1Lowl/J
005965   STOCK Tg(Pomc1-cre)16Lowl/J
012452   STOCK Tg(Rr5-GFP/cre)1Sapc/J
006395   STOCK Tg(Sim1-cre)1Lowl/J
009606   STOCK Tg(Six2-EGFP/cre)1Amc/J
019755   STOCK Tg(Six3-cre)69Frty/GcoJ
018147   STOCK Tg(Slc17a8-icre)1Edw/SealJ
012586   STOCK Tg(Slc1a3-cre/ERT)1Nat/J
004783   STOCK Tg(Sox2-cre)1Amc/J
008208   STOCK Tg(Stra8-icre)1Reb/J
016236   STOCK Tg(TCF/Lef1-cre/ERT2)1Dje/J
004746   STOCK Tg(Tagln-cre)1Her/J
012708   STOCK Tg(Thy1-cre/ERT2,-EYFP)HGfng/PyngJ
024240   STOCK Tg(Tnnt2-cre)5Blh/JiaoJ
016584   STOCK Tg(Tph2-icre/ERT2)6Gloss/J
003829   STOCK Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J
008851   STOCK Tg(Wnt1-cre/ERT)1Alj/J
018281   STOCK Tg(Wnt7a-EGFP/cre)#Bhr/Mmjax
008199   STOCK Tg(dlx6a-cre)1Mekk/J
002471   STOCK Tg(hCMV-cre)140Sau/J
023724   STOCK Tg(mI56i-cre,EGFP)1Kc/J
006224   STOCK Tg(tetO-cre)1Jaw/J
View Strains carrying other alleles of cre     (412 strains)

Additional Web Information

Introduction to Cre-lox technology


Phenotype Information

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Research Applications
This mouse can be used to support research in many areas including:

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      Cre Recombinase expression in neural tissue
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      Mutagenesis and Transgenesis: Cre-lox System

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol Tg(Camk2a-cre)T29-1Stl
Allele Name transgene insertion T29-1, Susumu Tonegawa
Allele Type Transgenic (cre- or Flp-expressing)
Common Name(s) CaMKIIalpha-cre; T29-1;
Mutation Made ByDr. Susumu Tonegawa,   Massachusetts Institute of Technology
Strain of Origin(C57BL x BALB/c)F1
Site of Expressionforebrain; pyramidal cell layer
Expressed Gene cre, cre recombinase, bacteriophage P1
Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence.
Promoter Camk2a, calcium/calmodulin-dependent protein kinase II alpha, mouse, laboratory
Driver Note Camk2a
Molecular Note This transgene directs the expression of Cre recombinase under the control of the alpha subunit of the calcium/calmodulin-dependent protein kinase II promoter. Cre recombinase activity was detected in the CA1 region of the hippocampus. [MGI Ref ID J:66344]


Genotyping Information

Genotyping Protocols

Generic Cre Quantitative PCR, QPCR
Generic Cre, Standard PCR

Helpful Links

Genotyping resources and troubleshooting


References provided by MGI

Selected Reference(s)

Tsien JZ; Chen DF; Gerber D; Tom C; Mercer EH; Anderson DJ; Mayford M; Kandel ER; Tonegawa S. 1996. Subregion- and cell type-restricted gene knockout in mouse brain [see comments] Cell 87(7):1317-26. [PubMed: 8980237]  [MGI Ref ID J:66344]

Additional References

Tg(Camk2a-cre)T29-1Stl related

Alberi L; Liu S; Wang Y; Badie R; Smith-Hicks C; Wu J; Pierfelice TJ; Abazyan B; Mattson MP; Kuhl D; Pletnikov M; Worley PF; Gaiano N. 2011. Activity-induced Notch signaling in neurons requires Arc/Arg3.1 and is essential for synaptic plasticity in hippocampal networks. Neuron 69(3):437-44. [PubMed: 21315255]  [MGI Ref ID J:174749]

Barbarese E; Ifrim MF; Hsieh L; Guo C; Tatavarty V; Maggipinto MJ; Korza G; Tutolo JW; Giampetruzzi A; Le H; Ma XM; Levine E; Bishop B; Kim DO; Kuwada S; Carson JH. 2013. Conditional knockout of tumor overexpressed gene in mouse neurons affects RNA granule assembly, granule translation, LTP and short term habituation. PLoS One 8(8):e69989. [PubMed: 23936366]  [MGI Ref ID J:205779]

Bongmba OY; Martinez LA; Elhardt ME; Butler K; Tejada-Simon MV. 2011. Modulation of dendritic spines and synaptic function by Rac1: A possible link to Fragile X syndrome pathology. Brain Res 1399:79-95. [PubMed: 21645877]  [MGI Ref ID J:174070]

Borgesius NZ; de Waard MC; van der Pluijm I; Omrani A; Zondag GC; van der Horst GT; Melton DW; Hoeijmakers JH; Jaarsma D; Elgersma Y. 2011. Accelerated age-related cognitive decline and neurodegeneration, caused by deficient DNA repair. J Neurosci 31(35):12543-53. [PubMed: 21880916]  [MGI Ref ID J:176221]

Bozdagi O; Wang XB; Nikitczuk JS; Anderson TR; Bloss EB; Radice GL; Zhou Q; Benson DL; Huntley GW. 2010. Persistence of coordinated long-term potentiation and dendritic spine enlargement at mature hippocampal CA1 synapses requires N-cadherin. J Neurosci 30(30):9984-9. [PubMed: 20668183]  [MGI Ref ID J:162856]

Brigman JL; Daut RA; Wright T; Gunduz-Cinar O; Graybeal C; Davis MI; Jiang Z; Saksida LM; Jinde S; Pease M; Bussey TJ; Lovinger DM; Nakazawa K; Holmes A. 2013. GluN2B in corticostriatal circuits governs choice learning and choice shifting. Nat Neurosci 16(8):1101-10. [PubMed: 23831965]  [MGI Ref ID J:203729]

Brigman JL; Wright T; Talani G; Prasad-Mulcare S; Jinde S; Seabold GK; Mathur P; Davis MI; Bock R; Gustin RM; Colbran RJ; Alvarez VA; Nakazawa K; Delpire E; Lovinger DM; Holmes A. 2010. Loss of GluN2B-containing NMDA receptors in CA1 hippocampus and cortex impairs long-term depression, reduces dendritic spine density, and disrupts learning. J Neurosci 30(13):4590-600. [PubMed: 20357110]  [MGI Ref ID J:159387]

Cabral HO; Fouquet C; Rondi-Reig L; Pennartz CM; Battaglia FP. 2014. Single-trial properties of place cells in control and CA1 NMDA receptor subunit 1-KO mice. J Neurosci 34(48):15861-9. [PubMed: 25429128]  [MGI Ref ID J:218191]

Caccamo A; De Pinto V; Messina A; Branca C; Oddo S. 2014. Genetic reduction of mammalian target of rapamycin ameliorates Alzheimer's disease-like cognitive and pathological deficits by restoring hippocampal gene expression signature. J Neurosci 34(23):7988-98. [PubMed: 24899720]  [MGI Ref ID J:211628]

Carlisle HJ; Luong TN; Medina-Marino A; Schenker L; Khorosheva E; Indersmitten T; Gunapala KM; Steele AD; O'Dell TJ; Patterson PH; Kennedy MB. 2011. Deletion of Densin-180 Results in Abnormal Behaviors Associated with Mental Illness and Reduces mGluR5 and DISC1 in the Postsynaptic Density Fraction. J Neurosci 31(45):16194-207. [PubMed: 22072671]  [MGI Ref ID J:177836]

Chan CS; Levenson JM; Mukhopadhyay PS; Zong L; Bradley A; Sweatt JD; Davis RL. 2007. Alpha3-integrins are required for hippocampal long-term potentiation and working memory. Learn Mem 14(9):606-15. [PubMed: 17848500]  [MGI Ref ID J:147820]

Chan CS; Weeber EJ; Zong L; Fuchs E; Sweatt JD; Davis RL. 2006. Beta1-integrins are required for hippocampal AMPA receptor-dependent synaptic transmission, synaptic plasticity, and working memory. J Neurosci 26(1):223-32. [PubMed: 16399691]  [MGI Ref ID J:104150]

Chao HT; Chen H; Samaco RC; Xue M; Chahrour M; Yoo J; Neul JL; Gong S; Lu HC; Heintz N; Ekker M; Rubenstein JL; Noebels JL; Rosenmund C; Zoghbi HY. 2010. Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes. Nature 468(7321):263-9. [PubMed: 21068835]  [MGI Ref ID J:166851]

Chen HZ; Guo S; Li ZZ; Lu Y; Jiang DS; Zhang R; Lei H; Gao L; Zhang X; Zhang Y; Wang L; Zhu LH; Xiang M; Zhou Y; Wan Q; Dong H; Liu DP; Li H. 2014. A critical role for interferon regulatory factor 9 in cerebral ischemic stroke. J Neurosci 34(36):11897-912. [PubMed: 25186738]  [MGI Ref ID J:216134]

Chen Q; Nakajima A; Choi SH; Xiong X; Sisodia SS; Tang YP. 2008. Adult neurogenesis is functionally associated with AD-like neurodegeneration. Neurobiol Dis 29(2):316-26. [PubMed: 17980611]  [MGI Ref ID J:141456]

Chinnakkaruppan A; Wintzer ME; McHugh TJ; Rosenblum K. 2014. Differential contribution of hippocampal subfields to components of associative taste learning. J Neurosci 34(33):11007-15. [PubMed: 25122900]  [MGI Ref ID J:216180]

Cook D; Nuro E; Jones EV; Altimimi HF; Farmer WT; Gandin V; Hanna E; Zong R; Barbon A; Nelson DL; Topisirovic I; Rochford J; Stellwagen D; Beique JC; Murai KK. 2014. FXR1P limits long-term memory, long-lasting synaptic potentiation, and de novo GluA2 translation. Cell Rep 9(4):1402-16. [PubMed: 25456134]  [MGI Ref ID J:218753]

Cui Z; Wang H; Tan Y; Zaia KA; Zhang S; Tsien JZ. 2004. Inducible and reversible NR1 knockout reveals crucial role of the NMDA receptor in preserving remote memories in the brain. Neuron 41(5):781-93. [PubMed: 15003177]  [MGI Ref ID J:88689]

Dong S; Li C; Wu P; Tsien JZ; Hu Y. 2007. Environment enrichment rescues the neurodegenerative phenotypes in presenilins-deficient mice. Eur J Neurosci 26(1):101-12. [PubMed: 17614943]  [MGI Ref ID J:125930]

Feng R; Rampon C; Tang YP; Shrom D; Jin J; Kyin M; Sopher B; Martin GM; Kim SH; Langdon RB; Sisodia SS; Tsien JZ. 2001. Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces. Neuron 32(5):911-26. [PubMed: 11738035]  [MGI Ref ID J:73252]

Feng R; Wang H; Wang J; Shrom D; Zeng X; Tsien JZ. 2004. Forebrain degeneration and ventricle enlargement caused by double knockout of Alzheimer's presenilin-1 and presenilin-2. Proc Natl Acad Sci U S A 101(21):8162-7. [PubMed: 15148382]  [MGI Ref ID J:90685]

Ferguson C; Hardy SL; Werner DF; Hileman SM; Delorey TM; Homanics GE. 2007. New insight into the role of the beta3 subunit of the GABAA-R in development, behavior, body weight regulation, and anesthesia revealed by conditional gene knockout. BMC Neurosci 8:85. [PubMed: 17927825]  [MGI Ref ID J:127877]

Fukaya M; Kato A; Lovett C; Tonegawa S; Watanabe M. 2003. Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice. Proc Natl Acad Sci U S A 100(8):4855-60. [PubMed: 12676993]  [MGI Ref ID J:83403]

Gaidamakov S; Maximova OA; Chon H; Blewett NH; Wang H; Crawford AK; Day A; Tulchin N; Crouch RJ; Morse HC 3rd; Blitzer RD; Maraia RJ. 2014. Targeted deletion of the gene encoding the La autoantigen (Sjogren's syndrome antigen B) in B cells or the frontal brain causes extensive tissue loss. Mol Cell Biol 34(1):123-31. [PubMed: 24190965]  [MGI Ref ID J:207687]

Gee JM; Smith NA; Fernandez FR; Economo MN; Brunert D; Rothermel M; Morris SC; Talbot A; Palumbos S; Ichida JM; Shepherd JD; West PJ; Wachowiak M; Capecchi MR; Wilcox KS; White JA; Tvrdik P. 2014. Imaging Activity in Neurons and Glia with a Polr2a-Based and Cre-Dependent GCaMP5G-IRES-tdTomato Reporter Mouse. Neuron :. [PubMed: 25155958]  [MGI Ref ID J:212315]

Genetic Resource Science at The Jackson Laboratory. 2008. Expression/Specificity Patterns of Cre Alleles Direct Data Submission from Genetic Resource Science :.  [MGI Ref ID J:137887]

Genetic Resource Science at The Jackson Laboratory. 2012. Expression/Specificity Patterns of Cre Alleles, 2011 Direct Data Submission from Genetic Resource Science :.  [MGI Ref ID J:184578]

Gould TD; O'Donnell KC; Picchini AM; Dow ER; Chen G; Manji HK. 2008. Generation and behavioral characterization of beta-catenin forebrain-specific conditional knock-out mice. Behav Brain Res 189(1):117-25. [PubMed: 18299155]  [MGI Ref ID J:132769]

Harris JA; Hirokawa KE; Sorensen SA; Gu H; Mills M; Ng LL; Bohn P; Mortrud M; Ouellette B; Kidney J; Smith KA; Dang C; Sunkin S; Bernard A; Oh SW; Madisen L; Zeng H. 2014. Anatomical characterization of Cre driver mice for neural circuit mapping and manipulation. Front Neural Circuits 8:76. [PubMed: 25071457]  [MGI Ref ID J:220523]

He M; Liu Y; Wang X; Zhang MQ; Hannon GJ; Huang ZJ. 2012. Cell-Type-Based Analysis of MicroRNA Profiles in the Mouse Brain. Neuron 73(1):35-48. [PubMed: 22243745]  [MGI Ref ID J:179351]

Heimer-McGinn V; Murphy AC; Kim JC; Dymecki SM; Young PW. 2013. Decreased dendritic spine density as a consequence of tetanus toxin light chain expression in single neurons in vivo. Neurosci Lett :. [PubMed: 24035894]  [MGI Ref ID J:201825]

Horn KE; Glasgow SD; Gobert D; Bull SJ; Luk T; Girgis J; Tremblay ME; McEachern D; Bouchard JF; Haber M; Hamel E; Krimpenfort P; Murai KK; Berns A; Doucet G; Chapman CA; Ruthazer ES; Kennedy TE. 2013. DCC expression by neurons regulates synaptic plasticity in the adult brain. Cell Rep 3(1):173-85. [PubMed: 23291093]  [MGI Ref ID J:196327]

Huang Z; Shimazu K; Woo NH; Zang K; Muller U; Lu B; Reichardt LF. 2006. Distinct roles of the beta 1-class integrins at the developing and the mature hippocampal excitatory synapse. J Neurosci 26(43):11208-19. [PubMed: 17065460]  [MGI Ref ID J:114964]

Ivanova E; Hwang GS; Pan ZH. 2010. Characterization of transgenic mouse lines expressing Cre recombinase in the retina. Neuroscience 165(1):233-43. [PubMed: 19837136]  [MGI Ref ID J:158209]

Jacobson L. 2014. Forebrain glucocorticoid receptor gene deletion attenuates behavioral changes and antidepressant responsiveness during chronic stress. Brain Res 1583:109-21. [PubMed: 25168761]  [MGI Ref ID J:215374]

Jiang Z; Belforte JE; Lu Y; Yabe Y; Pickel J; Smith CB; Je HS; Lu B; Nakazawa K. 2010. eIF2alpha Phosphorylation-dependent translation in CA1 pyramidal cells impairs hippocampal memory consolidation without affecting general translation. J Neurosci 30(7):2582-94. [PubMed: 20164343]  [MGI Ref ID J:157834]

Johnson AW; Crombag HS; Smith DR; Ramanan N. 2011. Effects of serum response factor (SRF) deletion on conditioned reinforcement. Behav Brain Res 220(2):312-8. [PubMed: 21329726]  [MGI Ref ID J:171461]

Kallhoff-Munoz V; Hu L; Chen X; Pautler RG; Zheng H. 2008. Genetic dissection of gamma-secretase-dependent and -independent functions of presenilin in regulating neuronal cell cycle and cell death. J Neurosci 28(44):11421-31. [PubMed: 18971484]  [MGI Ref ID J:143253]

Kanekiyo T; Cirrito JR; Liu CC; Shinohara M; Li J; Schuler DR; Shinohara M; Holtzman DM; Bu G. 2013. Neuronal clearance of amyloid-beta by endocytic receptor LRP1. J Neurosci 33(49):19276-83. [PubMed: 24305823]  [MGI Ref ID J:204149]

Kelleher RJ 3rd; Govindarajan A; Jung HY; Kang H; Tonegawa S. 2004. Translational control by MAPK signaling in long-term synaptic plasticity and memory. Cell 116(3):467-79. [PubMed: 15016380]  [MGI Ref ID J:88546]

Kim IH; Racz B; Wang H; Burianek L; Weinberg R; Yasuda R; Wetsel WC; Soderling SH. 2013. Disruption of Arp2/3 results in asymmetric structural plasticity of dendritic spines and progressive synaptic and behavioral abnormalities. J Neurosci 33(14):6081-92. [PubMed: 23554489]  [MGI Ref ID J:196577]

Kim SJ; Kwon MC; Ryu MJ; Chung HK; Tadi S; Kim YK; Man Kim J; Lee SH; Park JH; Kweon GR; Ryu SW; Jo YS; Lee CH; Hatakeyama H; Goto Y; Yim YH; Chung J; Kong YY; Shong M. 2012. CRIF1 Is Essential for the Synthesis and Insertion of Oxidative Phosphorylation Polypeptides in the Mammalian Mitochondrial Membrane. Cell Metab 16(2):274-83. [PubMed: 22819524]  [MGI Ref ID J:187395]

Kiselycznyk C; Svenningsson P; Delpire E; Holmes A. 2011. Genetic, pharmacological and lesion analyses reveal a selective role for corticohippocampal GLUN2B in a novel repeated swim stress paradigm. Neuroscience 193:259-68. [PubMed: 21704131]  [MGI Ref ID J:180351]

Liu CC; Hu J; Tsai CW; Yue M; Melrose HL; Kanekiyo T; Bu G. 2015. Neuronal LRP1 regulates glucose metabolism and insulin signaling in the brain. J Neurosci 35(14):5851-9. [PubMed: 25855193]  [MGI Ref ID J:221678]

Liu Q; Trotter J; Zhang J; Peters MM; Cheng H; Bao J; Han X; Weeber EJ; Bu G. 2010. Neuronal LRP1 knockout in adult mice leads to impaired brain lipid metabolism and progressive, age-dependent synapse loss and neurodegeneration. J Neurosci 30(50):17068-78. [PubMed: 21159977]  [MGI Ref ID J:167724]

Liu Q; Zerbinatti CV; Zhang J; Hoe HS; Wang B; Cole SL; Herz J; Muglia L; Bu G. 2007. Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1. Neuron 56(1):66-78. [PubMed: 17920016]  [MGI Ref ID J:126954]

Liu X; Gu QH; Duan K; Li Z. 2014. NMDA receptor-dependent LTD is required for consolidation but not acquisition of fear memory. J Neurosci 34(26):8741-8. [PubMed: 24966374]  [MGI Ref ID J:212385]

Madisen L; Zwingman TA; Sunkin SM; Oh SW; Zariwala HA; Gu H; Ng LL; Palmiter RD; Hawrylycz MJ; Jones AR; Lein ES; Zeng H. 2010. A robust and high-throughput Cre reporting and characterization system for the whole mouse brain. Nat Neurosci 13(1):133-40. [PubMed: 20023653]  [MGI Ref ID J:155793]

McMahon J; Huang X; Yang J; Komatsu M; Yue Z; Qian J; Zhu X; Huang Y. 2012. Impaired autophagy in neurons after disinhibition of mammalian target of rapamycin and its contribution to epileptogenesis. J Neurosci 32(45):15704-14. [PubMed: 23136410]  [MGI Ref ID J:192244]

Mirnics K; Norstrom EM; Garbett K; Choi SH; Zhang X; Ebert P; Sisodia SS. 2008. Molecular signatures of neurodegeneration in the cortex of PS1/PS2 double knockout mice. Mol Neurodegener 3:14. [PubMed: 18834536]  [MGI Ref ID J:187802]

Mirnics ZK; Yan C; Portugal C; Kim TW; Saragovi HU; Sisodia SS; Mirnics K; Schor NF. 2005. P75 neurotrophin receptor regulates expression of neural cell adhesion molecule 1. Neurobiol Dis 20(3):969-85. [PubMed: 16006137]  [MGI Ref ID J:104654]

Nijboer CH; Heijnen CJ; Willemen HL; Groenendaal F; Dorn GW 2nd; van Bel F; Kavelaars A. 2010. Cell-specific roles of GRK2 in onset and severity of hypoxic-ischemic brain damage in neonatal mice. Brain Behav Immun 24(3):420-6. [PubMed: 19932746]  [MGI Ref ID J:222368]

Nilsson P; Loganathan K; Sekiguchi M; Matsuba Y; Hui K; Tsubuki S; Tanaka M; Iwata N; Saito T; Saido TC. 2013. Abeta secretion and plaque formation depend on autophagy. Cell Rep 5(1):61-9. [PubMed: 24095740]  [MGI Ref ID J:203777]

Ning L; Tian L; Smirnov S; Vihinen H; Llano O; Vick K; Davis RL; Rivera C; Gahmberg CG. 2013. Interactions between ICAM-5 and beta1 integrins regulate neuronal synapse formation. J Cell Sci 126(Pt 1):77-89. [PubMed: 23015592]  [MGI Ref ID J:200266]

Park H; Popescu A; Poo MM. 2014. Essential role of presynaptic NMDA receptors in activity-dependent BDNF secretion and corticostriatal LTP. Neuron 84(5):1009-22. [PubMed: 25467984]  [MGI Ref ID J:217528]

Pieraut S; Gounko N; Sando R 3rd; Dang W; Rebboah E; Panda S; Madisen L; Zeng H; Maximov A. 2014. Experience-dependent remodeling of basket cell networks in the dentate gyrus. Neuron 84(1):107-22. [PubMed: 25277456]  [MGI Ref ID J:218035]

Raj DD; Jaarsma D; Holtman IR; Olah M; Ferreira FM; Schaafsma W; Brouwer N; Meijer MM; de Waard MC; van der Pluijm I; Brandt R; Kreft KL; Laman JD; de Haan G; Biber KP; Hoeijmakers JH; Eggen BJ; Boddeke HW. 2014. Priming of microglia in a DNA-repair deficient model of accelerated aging. Neurobiol Aging 35(9):2147-60. [PubMed: 24799273]  [MGI Ref ID J:213229]

Rajadhyaksha AM; Ra S; Kishinevsky S; Lee AS; Romanienko P; DuBoff M; Yang C; Zupan B; Byrne M; Daruwalla ZR; Mark W; Kosofsky BE; Toth M; Higgins JJ. 2012. Behavioral characterization of cereblon forebrain-specific conditional null mice: a model for human non-syndromic intellectual disability. Behav Brain Res 226(2):428-34. [PubMed: 21995942]  [MGI Ref ID J:179427]

Ramanan N; Shen Y; Sarsfield S; Lemberger T; Schutz G; Linden DJ; Ginty DD. 2005. SRF mediates activity-induced gene expression and synaptic plasticity but not neuronal viability. Nat Neurosci 8(6):759-67. [PubMed: 15880109]  [MGI Ref ID J:99232]

Rampon C; Tang YP; Goodhouse J; Shimizu E; Kyin M; Tsien JZ. 2000. Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice [see comments] Nat Neurosci 3(3):238-44. [PubMed: 10700255]  [MGI Ref ID J:60730]

Ren A; Zhang H; Xie Z; Ma X; Ji W; He DZ; Yuan W; Ding YQ; Zhang XH; Zhang WJ. 2012. Regulation of hippocampus-dependent memory by the zinc finger protein Zbtb20 in mature CA1 neurons. J Physiol 590(Pt 19):4917-32. [PubMed: 22777671]  [MGI Ref ID J:202369]

Rondi-Reig L; Libbey M; Eichenbaum H; Tonegawa S. 2001. CA1-specific N-methyl-D-aspartate receptor knockout mice are deficient in solving a nonspatial transverse patterning task. Proc Natl Acad Sci U S A 98(6):3543-8. [PubMed: 11248114]  [MGI Ref ID J:68059]

Rozas NS; Redell JB; McKenna J 3rd; Moore AN; Gambello MJ; Dash PK. 2015. Prolonging the survival of Tsc2 conditional knockout mice by glutamine supplementation. Biochem Biophys Res Commun 457(4):635-9. [PubMed: 25613864]  [MGI Ref ID J:220337]

Sarinana J; Kitamura T; Kunzler P; Sultzman L; Tonegawa S. 2014. Differential roles of the dopamine 1-class receptors, D1R and D5R, in hippocampal dependent memory. Proc Natl Acad Sci U S A 111(22):8245-50. [PubMed: 24843151]  [MGI Ref ID J:211355]

Sato C; Turkoz M; Dearborn JT; Wozniak DF; Kopan R; Hass MR. 2012. Loss of RBPj in postnatal excitatory neurons does not cause neurodegeneration or memory impairments in aged mice. PLoS One 7(10):e48180. [PubMed: 23110206]  [MGI Ref ID J:192302]

Shih PY; Savtchenko LP; Kamasawa N; Dembitskaya Y; McHugh TJ; Rusakov DA; Shigemoto R; Semyanov A. 2013. Retrograde synaptic signaling mediated by K+ efflux through postsynaptic NMDA receptors. Cell Rep 5(4):941-51. [PubMed: 24268779]  [MGI Ref ID J:206845]

Shimizu E; Tang YP; Rampon C; Tsien JZ. 2000. NMDA receptor-dependent synaptic reinforcement as a crucial process for memory consolidation. Science 290(5494):1170-4. [PubMed: 11073458]  [MGI Ref ID J:77659]

Skvorak K; Vissel B; Homanics GE. 2006. Production of conditional point mutant knockin mice. Genesis 44(7):345-53. [PubMed: 16832820]  [MGI Ref ID J:110982]

Sorrells SF; Caso JR; Munhoz CD; Hu CK; Tran KV; Miguel ZD; Chien BY; Sapolsky RM. 2013. Glucocorticoid signaling in myeloid cells worsens acute CNS injury and inflammation. J Neurosci 33(18):7877-89. [PubMed: 23637179]  [MGI Ref ID J:197150]

Stein LR; Wozniak DF; Dearborn JT; Kubota S; Apte RS; Izumi Y; Zorumski CF; Imai S. 2014. Expression of Nampt in hippocampal and cortical excitatory neurons is critical for cognitive function. J Neurosci 34(17):5800-15. [PubMed: 24760840]  [MGI Ref ID J:210614]

Sudarov A; Gooden F; Tseng D; Gan WB; Ross ME. 2013. Lis1 controls dynamics of neuronal filopodia and spines to impact synaptogenesis and social behaviour. EMBO Mol Med 5(4):591-607. [PubMed: 23483716]  [MGI Ref ID J:219053]

Tang G; Gudsnuk K; Kuo SH; Cotrina ML; Rosoklija G; Sosunov A; Sonders MS; Kanter E; Castagna C; Yamamoto A; Yue Z; Arancio O; Peterson BS; Champagne F; Dwork AJ; Goldman J; Sulzer D. 2014. Loss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficits. Neuron 83(5):1131-43. [PubMed: 25155956]  [MGI Ref ID J:217829]

Trinh MA; Kaphzan H; Wek RC; Pierre P; Cavener DR; Klann E. 2012. Brain-specific disruption of the eIF2alpha kinase PERK decreases ATF4 expression and impairs behavioral flexibility. Cell Rep 1(6):676-88. [PubMed: 22813743]  [MGI Ref ID J:196023]

Trotter J; Lee GH; Kazdoba TM; Crowell B; Domogauer J; Mahoney HM; Franco SJ; Muller U; Weeber EJ; D'Arcangelo G. 2013. Dab1 is required for synaptic plasticity and associative learning. J Neurosci 33(39):15652-68. [PubMed: 24068831]  [MGI Ref ID J:202682]

Tsien JZ; Huerta PT; Tonegawa S. 1996. The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory [see comments] Cell 87(7):1327-38. [PubMed: 8980238]  [MGI Ref ID J:37457]

Valor LM; Pulopulos MM; Jimenez-Minchan M; Olivares R; Lutz B; Barco A. 2011. Ablation of CBP in Forebrain Principal Neurons Causes Modest Memory and Transcriptional Defects and a Dramatic Reduction of Histone Acetylation But Does Not Affect Cell Viability. J Neurosci 31(5):1652-63. [PubMed: 21289174]  [MGI Ref ID J:168984]

Veeraraghavalu K; Sisodia SS. 2013. Mutant presenilin 1 expression in excitatory neurons impairs enrichment-mediated phenotypes of adult hippocampal progenitor cells. Proc Natl Acad Sci U S A 110(22):9148-53. [PubMed: 23674689]  [MGI Ref ID J:197420]

Veeraraghavalu K; Zhang C; Zhang X; Tanzi RE; Sisodia SS. 2014. Age-dependent, non-cell-autonomous deposition of amyloid from synthesis of beta-amyloid by cells other than excitatory neurons. J Neurosci 34(10):3668-73. [PubMed: 24599465]  [MGI Ref ID J:209619]

Vincent MY; Hussain RJ; Zampi ME; Sheeran K; Solomon MB; Herman JP; Khan A; Jacobson L. 2013. Sensitivity of depression-like behavior to glucocorticoids and antidepressants is independent of forebrain glucocorticoid receptors. Brain Res 1525:1-15. [PubMed: 23727405]  [MGI Ref ID J:218146]

Wiltgen BJ; Godsil BP; Peng Z; Saab F; June HL; Linn ML; Cook JM; Houser CR; O'Dell TJ; Homanics GE; Fanselow MS. 2009. The alpha1 subunit of the GABA(A) receptor modulates fear learning and plasticity in the lateral amygdala. Front Behav Neurosci 3:37. [PubMed: 19876409]  [MGI Ref ID J:180420]

Wu P; Shen Q; Dong S; Xu Z; Tsien JZ; Hu Y. 2008. Calorie restriction ameliorates neurodegenerative phenotypes in forebrain-specific presenilin-1 and presenilin-2 double knockout mice. Neurobiol Aging 29(10):1502-11. [PubMed: 17499883]  [MGI Ref ID J:140910]

Yamanaka T; Tosaki A; Kurosawa M; Akimoto K; Hirose T; Ohno S; Hattori N; Nukina N. 2013. Loss of aPKClambda in differentiated neurons disrupts the polarity complex but does not induce obvious neuronal loss or disorientation in mouse brains. PLoS One 8(12):e84036. [PubMed: 24391875]  [MGI Ref ID J:211115]

Yan L; Li L; Han W; Pan B; Xue X; Mei B. 2013. Age-related neuropsychiatric symptoms in presenilins conditional double knockout mice. Brain Res Bull 97:104-11. [PubMed: 23792007]  [MGI Ref ID J:205538]

Zhang H; Chen G; Kuang H; Tsien JZ. 2013. Mapping and deciphering neural codes of NMDA receptor-dependent fear memory engrams in the hippocampus. PLoS One 8(11):e79454. [PubMed: 24302990]  [MGI Ref ID J:209768]

Zhang Z; Yan J; Taheri S; Liu KJ; Shi H. 2014. Hypoxia-inducible factor 1 contributes to N-acetylcysteine's protection in stroke. Free Radic Biol Med 68:8-21. [PubMed: 24296245]  [MGI Ref ID J:211876]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX10

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, these mice are bred as homozygotes.
Mating SystemHomozygote x Homozygote         (Female x Male)   22-AUG-06
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $239.00Female or MaleHomozygous for Tg(Camk2a-cre)T29-1Stl  
Price per Pair (US dollars $)Pair Genotype
$478.00Homozygous for Tg(Camk2a-cre)T29-1Stl x Homozygous for Tg(Camk2a-cre)T29-1Stl  

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $310.70Female or MaleHomozygous for Tg(Camk2a-cre)T29-1Stl  
Price per Pair (US dollars $)Pair Genotype
$621.40Homozygous for Tg(Camk2a-cre)T29-1Stl x Homozygous for Tg(Camk2a-cre)T29-1Stl  

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

   000664 C57BL/6J
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.

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Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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Terms of Use

Terms of Use

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For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty


In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.