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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Type Coisogenic; Mutant Strain; Spontaneous Mutation; Additional information on Genetically Engineered Mutant Mice. Species Outbred and M. m. domesticus Generation F?+64+27 (07-DEC-07) Important Note
This genetic background is homozygous for Robertsonian translocations Rb(1.3)1Bnr, Rb(8.12)5Bnr, and Rb(9.14)6Bnr.Description
The phenotype of this mutation can be identified at about 10 days of age by a ruffled looking coat, which is different than the smooth coat of control littermates. The hair of mutant mice is sparse and has some curling. The ruffled looking coat is maintained throughout the animal's lifespan, unlike the caracul and caracul-like mutants who lose some of their curly coat with age. Mice homozygous for the ruffled mutation have a normal lifespan and both sexes breed normally.Development
Rb(1.3)1Bnr, Rb(4.6)2Bnr, Rb(5.15)3Bnr, Rb(11.13)4Bnr, Rb(8.12)5Bnr, Rb(9.14)6Bnr, and Rb(16.17)7Bnr were identified in the progeny of tobacco mice trapped in Val Poschiavo, Switzerland. A female from the random bred Swiss NMRI/Han stock was bred to a male descended from the mice trapped in Val Poschiavo and their F1 offspring were sent from Dr. Alfred Gropp at Medizinische Hochschule, Lubeck, to Dr. Thomas Roderick at The Jackson Laboratory where they were intercrossed and the F2 offpsring were separated into distinct breeding lines maintained by sibling mating. This generated a panel of recombinant inbred strains, some of which were developed by Dr. Eva Eicher, including RB126Bnr/EiJ (stock #002040). This strain is homozygous for Rb(1.3)1Bnr, Rb(4.6)2Bnr, and Rb(9.14)6Bnr. The rul mutation arose spontaneously in the RB126Bnr/EiJ strain at The Jackson Laboratory in 1989 and since then has been maintained segregating for rul by sibling mating primarily heterozygotes with homozygotes.
Control Information
| Control | ||
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| Heterozygote | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying rul allele
005354 RB156Bnr/Ei rul-Gulosfx-2J/J View Strains carrying rul (1 strain)
Phenotype
Phenotype Information
assigned by genotype
rul/rul
RB156Bnr/Ei-rul/J
- skin/coat/nails phenotype
- ruffled hair (MGI Ref ID J:96444)
- ruffled looking coat apparent at 10 days of age; sparse hairs with some curling; coat is not lost with age
This mouse can be used to support research in many areas including:rul related
Dermatology Research
Skin and Hair Texture Defects
Genes & Alleles
Gene & Allele Information
| Allele Symbol | rul | ||
|---|---|---|---|
| Allele Name | ruffled | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | RB156Bnr/Ei | ||
| Molecular Note | This spontaneous mutation was discovered in 1989 at The Jackson Laboratory. | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Optimizing PCR Protocols
References
References
Selected Reference(s)
Original article from The Mouse Mutant ResourceHarris BS; Ward-Bailey PF; Johnson KR; Bronson RT; Davisson MT. 2005. A New Hair Mutation Named Ruffled Maps to Chromosome 13 MGI Direct Data Submission :. [MGI Ref ID J:96444]
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Weeks of Age Price* Gender Genotypes Provided Individual Mouse Price $127.90 Female or Male Homozygous for rul *Price(s) in US dollars ($)
Pairs /Price* Pair Genotype $255.80 Heterozygous for rul x Heterozygous for rul $255.80 Heterozygous for rul x Homozygous for rul $255.80 Homozygous for rul x Heterozygous for rul
Additional Supply Details
| Supply Notes |
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| Pricing for International shipping destinations |
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Weeks of Age Price* Gender Genotypes Provided Individual Mouse Price $166.30 Female or Male Homozygous for rul *Price(s) in US dollars ($)
Pairs /Price* Pair Genotype $332.60 Heterozygous for rul x Heterozygous for rul $332.60 Heterozygous for rul x Homozygous for rul $332.60 Homozygous for rul x Heterozygous for rul
Additional Supply Details
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement. |
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| Supply Notes |
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| Important Note | This genetic background is homozygous for Robertsonian translocations Rb(1.3)1Bnr, Rb(8.12)5Bnr, and Rb(9.14)6Bnr. |
Control Information
| Control | ||
|---|---|---|
| Heterozygote | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
General Terms and Conditions
See Terms of Use
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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Contact Information
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Terms of Use
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Contact information
General inquiries
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| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice & Services Conditions of Use
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