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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Former Names RB156Bnr/Ei-rul/J (Changed: 22-JUN-09 ) Type Coisogenic; Mutant Strain; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species Outbred and M. m. domesticus Important Note
This genetic background is homozygous for Robertsonian translocations Rb(1.3)1Bnr, Rb(8.12)5Bnr, and Rb(9.14)6Bnr.Description
The phenotype of this mutation can be identified at about 10 days of age by a ruffled looking coat, which is different than the smooth coat of control littermates. The hair of mutant mice is sparse and has some curling. The ruffled looking coat is maintained throughout the animal's lifespan, unlike the caracul and caracul-like mutants who lose some of their curly coat with age. Mice homozygous for the ruffled mutation have a normal lifespan and both sexes breed normally.Development
Rb(1.3)1Bnr, Rb(4.6)2Bnr, Rb(5.15)3Bnr, Rb(11.13)4Bnr, Rb(8.12)5Bnr, Rb(9.14)6Bnr, and Rb(16.17)7Bnr were identified in the progeny of tobacco mice trapped in Val Poschiavo, Switzerland. A female from the random bred Swiss NMRI/Han stock was bred to a male descended from the mice trapped in Val Poschiavo and their F1 offspring were sent from Dr. Alfred Gropp at Medizinische Hochschule, Lubeck, to Dr. Thomas Roderick at The Jackson Laboratory where they were intercrossed and the F2 offpsring were separated into distinct breeding lines maintained by sibling mating. This generated a panel of recombinant inbred strains, some of which were developed by Dr. Eva Eicher, including RB126Bnr/EiJ (stock #002040). This strain is homozygous for Rb(1.3)1Bnr, Rb(4.6)2Bnr, and Rb(9.14)6Bnr. The rul mutation arose spontaneously in the RB126Bnr/EiJ strain at The Jackson Laboratory in 1989 and since then has been maintained segregating for rul by sibling mating primarily heterozygotes with homozygotes.
Control Information
| Control | ||
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| Heterozygote | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying rul allele
005354 RB156Bnr/Ei rul-Gulosfx-2J/GrsrJ View Strains carrying rul (1 strain)
005354 RB156Bnr/Ei rul-Gulosfx-2J/GrsrJ
Phenotype
Phenotype Information
assigned by genotype
rul/rul
RB156Bnr/Ei-rul/GrsrJ
- integument phenotype
- ruffled hair
- ruffled looking coat apparent at 10 days of age; sparse hairs with some curling; coat is not lost with age (MGI Ref ID J:96444)
This mouse can be used to support research in many areas including:rul related
Dermatology Research
Skin and Hair Texture Defects
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | rul | ||
|---|---|---|---|
| Allele Name | ruffled | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | RB156Bnr/Ei | ||
| Gene Symbol and Name | rul, ruffled | ||
| Chromosome | 13 | ||
| Molecular Note | This spontaneous mutation was discovered in 1989 at The Jackson Laboratory. | ||
References
References provided by MGI
Selected Reference(s)
Harris BS; Ward-Bailey PF; Johnson KR; Bronson RT; Davisson MT. 2005. A New Hair Mutation Named Ruffled Maps to Chromosome 13 MGI Direct Data Submission :. [MGI Ref ID J:96444]
Purchasing information
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Live Mice
Price (US dollars $) Gender Genotypes Provided Individual Mouse $242.00 Female or Male Homozygous for rul
Pairs /Price (US dollars $) Pair Genotype $310.00 Heterozygous for rul x Heterozygous for rul $397.00 Heterozygous for rul x Homozygous for rul $397.00 Homozygous for rul x Heterozygous for rul Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
| Pricing for International shipping destinations |
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Live Mice
Price (US dollars $) Gender Genotypes Provided Individual Mouse $314.60 Female or Male Homozygous for rul
Pairs /Price (US dollars $) Pair Genotype $403.00 Heterozygous for rul x Heterozygous for rul $516.10 Heterozygous for rul x Homozygous for rul $516.10 Homozygous for rul x Heterozygous for rul Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
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Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
General Supply Notes
- This strain is included in the Mouse Mutant Resource collection.
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| Heterozygote | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Important Note
This genetic background is homozygous for Robertsonian translocations Rb(1.3)1Bnr, Rb(8.12)5Bnr, and Rb(9.14)6Bnr.
Payment Terms and Conditions
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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