Description

Strain Information

Type Coisogenic; Mutant Strain; Spontaneous Mutation; Additional information on Genetically Engineered Mutant Mice. Mating System Homozygote x Heterozygote         (Female x Male) Mating System Heterozygote x Homozygote         (Female x Male) Species laboratory mouse Generation F121+29 (06-DEC-07)

Appearance
albino, unaffected
Related Genotype: a/a Tyrp^b/Tyrp1^b Tyr^c/Tyr^c stmp/+

albino, transitory curly hair
Related Genotype: a/a Tyrp^b/Tyrp1^b Tyr^c/Tyr^c stmp/stmp

Description
The phenotype of this mutation can be identified by a curly coat, which is different from the smooth coat of control littermates. At 3 weeks of age, mice homozygous for this new mutation have very curly coats and slightly curved vibrissae. In several weeks time the curly coat disappears but the hair retains a rough texture, and the vibrissae then appear normal. Heterozygous mice have normal smooth coats and straight whiskers.

Development
The short term perm mutation arose spontaneously on the RHJ/LeJ background at The Jackson Laboratory in 1998 when that strain was at F121. This mutant substrain was subsequently maintained by sibling mating primarily heterozygotes with homozygotes and vice versa. The recessive rhino mutation has never been seen in this substrain although it had to have been present heterozygously in the founders. In 2005 this strain reached F121+F23.

Control Information

	Control
	Heterozygote from the colony
Considerations for Choosing Controls

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms

      assigned by genotype

stpm/stpm

        RHJ/LeJ-stpm/J

• skin/coat/nails phenotype
• *normal* skin/coat/nails phenotype (MGI Ref ID J:100186)
  • at 4-5 weeks of age, the skin is histologically normal
• abnormal guard hair (MGI Ref ID J:100186)
  • guard hairs are rare
• abnormal zigzag hairs (MGI Ref ID J:100186)
  • at 4-5 weeks of age, the zigzag hairs have abnormal bends and kinks and a few of the hairs have variable thickness
• rough hair (MGI Ref ID J:100186)
  • with age, curly coat disappears but hair retains a rough texture
• waved hair (MGI Ref ID J:100186)
  • at three weeks of age, mice have very curly coats
  • with age, the curly coat disappears
• touch/vibrissae phenotype
• curly vibrissae (MGI Ref ID J:100186)
  • at three weeks of age, vibrissae appear slightly curved
  • this phenotype disappears with age

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

stpm related

Dermatology Research
Skin and Hair Texture Defects

Developmental Biology Research
Skin and Hair Texture Defects

Genes & Alleles

Gene & Allele Information

Allele Symbol		stpm
Allele Name		short term perm
Allele Type		Spontaneous
Strain of Origin		RHJ/LeJ
Molecular Note		This spontaneous mutation arose at The Jackson Laboratory.

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Optimizing PCR Protocols

References

References

Selected Reference(s)

Samples RM; Ward-Bailey PF; Donahue LR; Bronson RT; Davisson MT. 2005. Short term perm (stpm): a new recessive curly coat mutation MGI Direct Data Submission :.  [MGI Ref ID J:100186]

Original article from The Mouse Mutant Resource

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           A1

Colony Maintenance

Mating System	Homozygote x Heterozygote         (Female x Male)
	Heterozygote x Homozygote         (Female x Male)

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Supply Details

Standard Supply

Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.

Supply Notes

Usually shipped between four and eight weeks of age. This strain is included in the Mouse Mutant Resource collection.

Control Information

	Control
	Heterozygote from the colony
Considerations for Choosing Controls
USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
International - Control Pricing Information for Genetically Engineered Mutant Strains.

General Terms and Conditions

See Terms of Use

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Ordering and Purchasing Information

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Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form

Terms of Use

Terms of Use

General Terms and Conditions

Contact information

General inquiries

Contracts Administration

phone:	207-288-6470
fax:	207-288-6655

JAX^® Mice & Services Conditions of Use

“Each recipient institution, including its employees and other researchers under its control (RECIPIENT), of mice or services using mice from The Jackson Laboratory (TJL) agrees that such mice, descendants of those mice derived by inbreeding or crossbreeding, including unmodified derivatives of those mice or their descendants (“MICE”) shall not be: (i) used for any purpose other than the internal research of the RECIPIENT, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services with respect to MICE. Acceptance of MICE from TJL shall be deemed agreement by RECIPIENT to these conditions, and departure from these conditions requires The Jackson Laboratory’s prior written authorization.”

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of MICE, products or services, The Jackson Laboratory will, at its option, provide credit or replacement for the MICE or product received or the services provided.

No Liability

In no event shall The Jackson Laboratory, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, products or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of The Jackson Laboratory, its agents or employees. In purchasing or receiving MICE, products or services from The Jackson Laboratory, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges The Jackson Laboratory from all such causes of action or damages, and further agrees to defend and indemnify The Jackson Laboratory from any costs or damages arising out of any third party claims.

MICE and biological materials are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to The Jackson Laboratory’s MICE, products and services. In addition, special terms and conditions of sale of certain MICE, products and services may be set forth separately in The Jackson Laboratory web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, products and services by The Jackson Laboratory, and by its licensees and distributors.

Acceptance of delivery of MICE, products or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on The Jackson Laboratory, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, products services by The Jackson Laboratory.