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Strain Name:

C;129S7 Gt(ROSA)26Sor-Bmp5cfe-se7J/J

Stock Number:

005420

Availability:

Repository-Cryopreserved

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Genes & Alleles   Bmp5;   Bmp5cfe-se7J;   Gt(ROSA)26Sor;

Product Information

Strain Details

Type JAX® GEMM® Strain - Gene Trap
Additional information on JAX® GEMM® Strains.
Type JAX® GEMM® Strain - Mutant Stock
Type JAX® GEMM® Strain - Mutant Strain
Type JAX® GEMM® Strain - Spontaneous Mutation
Specieslaboratory mouse
Generation+F8N1F2pN1

Important Note
This strain is segregating for Gt(ROSA)26Sor.

Strain Development
The cauliflower ear mutation arose spontaneously in 2002 in the production colony of C.129S7-Gt(ROSA)26Sor/J (stock #002255) at The Jackson Laboratory. The mutant subline was maintained by sibling breeding for 8 generations, then backcrossed once to BALB/cJ, and then intercrossed. In 2007 sperm were cryopreserved from homozygous Males at generation +F8N1F2.

Mammalian Phenotype Terms assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Bmp5cfe-se7J/Bmp5cfe-se7J

        involves: 129S7/SvEvBrd * BALB/cJ
  • craniofacial phenotype
  • abnormal ear shape (MGI Ref ID J:123049)
    • both ears are smaller than normal and have round ear pinnae with ridges around the perimeter
  • abnormal skull morphology (MGI Ref ID J:123049)
    • male homozygotes have greater skull height than controls, but female homozygotes have a statistically insignificant decrease in skull height
    • the skull length to nose length ratio is decreased in females
    • the skull height to skull length ratio is increased in males
    • the skull length to skull width ratio is decreased in both males and females
    • the skull height to skull width ratio is increased in males
    • longitudinally short skull (MGI Ref ID J:123049)
      • males and females have shorter skull lengths than do controls
    • short mandible (MGI Ref ID J:123049)
      • shortened lower jaw length is statistically significant in females, but not statistically significant in males
    • short maxilla (MGI Ref ID J:123049)
      • shortened upper jaw length is statistically significant in males, but not statistically significant in females
  • lowered ear position (MGI Ref ID J:123049)
  • short snout (MGI Ref ID J:123049)
  • skeleton phenotype
  • *normal* skeleton phenotype (MGI Ref ID J:123049)
    • no abnormality was found in spine length, ratios of tail length to back length, femur length to back length or spine length to back length
    • abnormal skull morphology (MGI Ref ID J:123049)
      • male homozygotes have greater skull height than controls, but female homozygotes have a statistically insignificant decrease in skull height
      • the skull length to nose length ratio is decreased in females
      • the skull height to skull length ratio is increased in males
      • the skull length to skull width ratio is decreased in both males and females
      • the skull height to skull width ratio is increased in males
      • longitudinally short skull (MGI Ref ID J:123049)
        • males and females have shorter skull lengths than do controls
      • short mandible (MGI Ref ID J:123049)
        • shortened lower jaw length is statistically significant in females, but not statistically significant in males
      • short maxilla (MGI Ref ID J:123049)
        • shortened upper jaw length is statistically significant in males, but not statistically significant in females
    • decreased bone density (MGI Ref ID J:123049)
      • whole body bone mineral density is decreased in both females and males
  • hearing/vestibular/ear phenotype
  • *normal* hearing/vestibular/ear phenotype (MGI Ref ID J:123049)
    • ABR threshold analysis at three months of age indicates normal hearing
    • abnormal ear shape (MGI Ref ID J:123049)
      • both ears are smaller than normal and have round ear pinnae with ridges around the perimeter
    • lowered ear position (MGI Ref ID J:123049)
  • respiratory system phenotype
  • abnormal nose morphology (MGI Ref ID J:123049)
    • females have shorter nose lengths than controls, but the shortened nose lenghts of male homozygotes was not found statistically significant

Gene & Allele Details

Allele Symbol Bmp5cfe-se7J
Allele Name cauliflower ear short ear 7 Jackson
Strain of OriginC.129S7-Gt(ROSA)26Sor/J
Gene Symbol and Name Bmp5, bone morphogenetic protein 5
Chromosome 9
Gene Common Name(s) AU023399; MGC34244; expressed sequence AU023399; se; short ear;
Molecular Note The cauliflower ear mutation was found to be allelic with the short ear mutation through a noncomplementation test.
 
Allele Symbol Gt(ROSA)26Sor
Allele Name gene trap ROSA 26, Philippe Soriano
Common Name(s) ROSA26; ROSA26-lacZ; Rosa26lacZ; TgR(ROSA26)26Sor; gtrosa26;
Mutation Made By Philippe Soriano,   Fred Hutchinson Cancer Research Center
Strain of Origin129 x C57BL/6J
Site of ExpressionAll tissues of the developing embryo and in most tissues of the adult mouse.
General Note No overt phenotypes in heterozygous or homozygous animals. The trapped gene appears to be ubiquitously expressed during embryonic development and in all hematopoietic cells.
Molecular Note Random insertion of retroviral gene trap vector ROSA, Reverse Orientation with Splice Acceptor, which contains the beta-galactosidase gene and accompanying splice acceptor and neo sequences. The construct was inserted in reverse orientation in the retroviral vector pGen-. The transgene is controlled by an unknown endogenous promoter. lacZ is expressed in all tissues of the developing embryo and in most tissues of the adult transgenic mouse.

Genotyping Protocols

Gt(ROSA)26Sor, Gt(ROSA)26Sortm1Sho

Related Strains

Strains carrying   Gt(ROSA)26Sor allele
002292   129-Gt(ROSA)26Sor/J
002192   B6.129S7-Gt(ROSA)26Sor/J
002073   B6;129S-Gt(ROSA)26Sor/J
002955   C.129S7-Gt(ROSA)26Sor/J
View Strains carrying   Gt(ROSA)26Sor     (4 strains)

Strains carrying other alleles of Bmp5
000004   ABP/LeJ
000578   B6 x STOCK Tyrc-ch Bmp5se +/+ Myo6sv/J
000056   B6.Cg-Bmp5se/J
000285   B6.Cg-Rorasg + +/+ Myo5ad Bmp5se/J
001496   C57BL/6J-Bmp5se-4J/J
005421   CBy;B6-Bmp5cfe-se8J/J
000253   DLS/LeJ
000644   SEA/GnJ
000270   SEC/1GnLeJ
View Strains carrying other alleles of Bmp5     (9 strains)

Strains carrying other alleles of Gt(ROSA)26Sor
006053   129-Gt(ROSA)26Sortm1Luo/J
006067   129-Gt(ROSA)26Sortm2Luo/J
006041   129-Gt(ROSA)26Sortm3Luo/J
003310   129S-Gt(ROSA)26Sortm1Sor/J
003946   129S4/SvJaeSor-Gt(ROSA)26Sortm1(FLP1)Dym/J
007689   129S4/SvJaeSor-Gt(ROSA)26Sortm4(attB/attP)Sor/J
007708   B6.129-Gt(ROSA)26Sortm1(HD*103Q)Xwy/J
006071   B6.129-Gt(ROSA)26Sortm1Luo/J
006080   B6.129-Gt(ROSA)26Sortm2Luo/J
006075   B6.129-Gt(ROSA)26Sortm3Luo/J
003474   B6.129S4-Gt(ROSA)26Sortm1Sor/J
006148   B6.129X1-Gt(ROSA)26Sortm1(EYFP)Cos/J
006965   B6.Cg-Gt(ROSA)26Sortm1(rtTA*M2)Jae/J
005670   B6.Cg-Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/J
004847   B6;129-Gt(ROSA)26Sortm1(cre/Esr1)Nat/J
006911   B6;129-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm2(tetO-Pou5f1)Jae/J
003504   B6;129-Gt(ROSA)26Sortm1Sho/J
004077   B6;129-Gt(ROSA)26Sortm2Sho/J
003309   B6;129S4-Gt(ROSA)26Sortm1Sor/J
004598   B6;129S4-Gt(ROSA)26Sortm2Dym/J
007670   B6;129S4-Gt(ROSA)26Sortm3(phiC31*)Sor/J
007900   C57BL/6-Gt(ROSA)26Sortm1(HBEGF)Awai/J
008242   C57BL/6-Gt(ROSA)26Sortm1(Ikbkb)Rsky/J
005125   FVB.129S6(B6)-Gt(ROSA)26Sortm1(Luc)Kael/J
006206   FVB.129S6-Gt(ROSA)26Sortm1(HIF1A/luc)Kael/J
006331   STOCK Gt(ROSA)26Sortm1(DTA)Jpmb/J
008159   STOCK Gt(ROSA)26Sortm1(Notch1)Dam/J
005130   STOCK Gt(ROSA)26Sortm1(Smo/EYFP)Amc/J
005572   STOCK Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/J
007576   STOCK Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/J
007577   STOCK Tg(Gt(ROSA)26Sor-BCHE*G117H)837Loc/J
007896   STOCK Tg(Gt(ROSA)26Sor-EGFP)I1Able/J
View Strains carrying other alleles of Gt(ROSA)26Sor     (32 strains)

References

Additional References

Price and Supply Information

Strain Name: C;129S7 Gt(ROSA)26Sor-Bmp5cfe-se7J/J
Stock Number: 005420

Price Details

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Supply Details

Standard SupplyRepository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes Cryorecovery - Standard.
The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery.

Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services: Tel: 1-800-422-6423 or 1-207-288-5845; Email: jaxservices@jax.org.
Genomic DNA is available for this strain from the Mouse DNA Resource.

LicensingSee General Terms and Conditions below for Licensing and Use Restrictions  

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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