Strain Name: |
C;129S7 Gt(ROSA)26Sor-Bmp5cfe-se7J/J |
|---|---|
Stock Number: |
005420 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Genes & Alleles | Bmp5; Bmp5cfe-se7J; Gt(ROSA)26Sor; |
Type JAX® GEMM® Strain - Gene Trap Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Mutant Stock Type JAX® GEMM® Strain - Mutant Strain Type JAX® GEMM® Strain - Spontaneous Mutation Species laboratory mouse Generation +F8N1F2pN1 Important Note
This strain is segregating for Gt(ROSA)26Sor.Strain Development
The cauliflower ear mutation arose spontaneously in 2002 in the production colony of C.129S7-Gt(ROSA)26Sor/J (stock #002255) at The Jackson Laboratory. The mutant subline was maintained by sibling breeding for 8 generations, then backcrossed once to BALB/cJ, and then intercrossed. In 2007 sperm were cryopreserved from homozygous Males at generation +F8N1F2.
Mammalian Phenotype Terms assigned by genotype |
| Allele Symbol | Bmp5cfe-se7J | ||
|---|---|---|---|
| Allele Name | cauliflower ear short ear 7 Jackson | ||
| Strain of Origin | C.129S7-Gt(ROSA)26Sor/J | ||
| Gene Symbol and Name | Bmp5, bone morphogenetic protein 5 | ||
| Chromosome | 9 | ||
| Gene Common Name(s) | AU023399; MGC34244; expressed sequence AU023399; se; short ear; | ||
| Molecular Note | The cauliflower ear mutation was found to be allelic with the short ear mutation through a noncomplementation test. | ||
| Allele Symbol | Gt(ROSA)26Sor | ||
| Allele Name | gene trap ROSA 26, Philippe Soriano | ||
| Common Name(s) | ROSA26; ROSA26-lacZ; Rosa26lacZ; TgR(ROSA26)26Sor; gtrosa26; | ||
| Mutation Made By | Philippe Soriano, Fred Hutchinson Cancer Research Center | ||
| Strain of Origin | 129 x C57BL/6J | ||
| Site of Expression | All tissues of the developing embryo and in most tissues of the adult mouse. | ||
| General Note | No overt phenotypes in heterozygous or homozygous animals. The trapped gene appears to be ubiquitously expressed during embryonic development and in all hematopoietic cells. | ||
| Molecular Note | Random insertion of retroviral gene trap vector ROSA, Reverse Orientation with Splice Acceptor, which contains the beta-galactosidase gene and accompanying splice acceptor and neo sequences. The construct was inserted in reverse orientation in the retroviral vector pGen-. The transgene is controlled by an unknown endogenous promoter. lacZ is expressed in all tissues of the developing embryo and in most tissues of the adult transgenic mouse. | ||
Gt(ROSA)26Sor, Gt(ROSA)26Sortm1Sho
Strains carrying Gt(ROSA)26Sor allele
002292 129-Gt(ROSA)26Sor/J 002192 B6.129S7-Gt(ROSA)26Sor/J 002073 B6;129S-Gt(ROSA)26Sor/J 002955 C.129S7-Gt(ROSA)26Sor/J View Strains carrying Gt(ROSA)26Sor (4 strains)
Strains carrying other alleles of Bmp5
000004 ABP/LeJ 000578 B6 x STOCK Tyrc-ch Bmp5se +/+ Myo6sv/J 000056 B6.Cg-Bmp5se/J 000285 B6.Cg-Rorasg + +/+ Myo5ad Bmp5se/J 001496 C57BL/6J-Bmp5se-4J/J 005421 CBy;B6-Bmp5cfe-se8J/J 000253 DLS/LeJ 000644 SEA/GnJ 000270 SEC/1GnLeJ View Strains carrying other alleles of Bmp5 (9 strains)
Strains carrying other alleles of Gt(ROSA)26Sor
View Strains carrying other alleles of Gt(ROSA)26Sor (32 strains)
| Strain Name: | C;129S7 Gt(ROSA)26Sor-Bmp5cfe-se7J/J |
| Stock Number: | 005420 |
IMPORTANT NOTE: Prices are based on shipping destination. To view prices, select your shipping destination.
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Licensing | See General Terms and Conditions below for Licensing and Use Restrictions |
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