| |||||||||||||||
- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Type Gene Trap; Mutant Stock; Mutant Strain; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation +F8N1F2pN1 Important Note
This strain is segregating for Gt(ROSA)26Sor.Description
Homozygotes have small, round ear pinnae with ridges along the perimeter and both ears are affected. This mutation is 100% penetrant. Unlike short ear mutations of this gene, skeletal abnormalities were not detected by X-ray for this mutant. Both males and females are fertile.Development
The cauliflower ear mutation arose spontaneously in 2002 in the production colony of C.129S7-Gt(ROSA)26Sor/J (stock #002255) at The Jackson Laboratory. The mutant subline was maintained by sibling breeding for 8 generations, then backcrossed once to BALB/cJ, and then intercrossed. In 2007 sperm were cryopreserved from homozygous Males at generation +F8N1F2.
Related Strains
Strains carrying Gt(ROSA)26Sor allele
002292 129-Gt(ROSA)26Sor/J 002192 B6.129S7-Gt(ROSA)26Sor/J 002073 B6;129S-Gt(ROSA)26Sor/J 002955 C.129S7-Gt(ROSA)26Sor/J View Strains carrying Gt(ROSA)26Sor (4 strains)
000004 ABP/LeJ 000578 B6 x STOCK Tyrc-ch Bmp5se +/+ Myo6sv/J 001496 B6(Cg)-Bmp5se-4J/J 000056 B6.Cg-Bmp5se/J 000285 B6.Cg-Rorasg + +/+ Myo5ad Bmp5se/J 005348 BALB/cByJ Agtpbp1pcd-3J-Bmp5cfe-se6J/GrsrJ 005421 CBy;B6-Bmp5cfe-se8J/J 000253 DLS/LeJ 000644 SEA/GnJ 000270 SEC/1GnLeJ
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Bmp5cfe-se7J/Bmp5cfe-se7J
involves: 129S7/SvEvBrd * BALB/cJ
- craniofacial phenotype
- abnormal ear shape (MGI Ref ID J:123049)
- both ears are smaller than normal and have round ear pinnae with ridges around the perimeter
- abnormal skull morphology (MGI Ref ID J:123049)
- male homozygotes have greater skull height than controls, but female homozygotes have a statistically insignificant decrease in skull height
- the skull length to nose length ratio is decreased in females
- the skull height to skull length ratio is increased in males
- the skull length to skull width ratio is decreased in both males and females
- the skull height to skull width ratio is increased in males
- longitudinally short skull (MGI Ref ID J:123049)
- males and females have shorter skull lengths than do controls
- short mandible (MGI Ref ID J:123049)
- shortened lower jaw length is statistically significant in females, but not statistically significant in males
- short maxilla (MGI Ref ID J:123049)
- shortened upper jaw length is statistically significant in males, but not statistically significant in females
- lowered ear position (MGI Ref ID J:123049)
- short snout (MGI Ref ID J:123049)
- skeleton phenotype
- *normal* skeleton phenotype (MGI Ref ID J:123049)
- no abnormality was found in spine length, ratios of tail length to back length, femur length to back length or spine length to back length
- abnormal skull morphology (MGI Ref ID J:123049)
- male homozygotes have greater skull height than controls, but female homozygotes have a statistically insignificant decrease in skull height
- the skull length to nose length ratio is decreased in females
- the skull height to skull length ratio is increased in males
- the skull length to skull width ratio is decreased in both males and females
- the skull height to skull width ratio is increased in males
- longitudinally short skull (MGI Ref ID J:123049)
- males and females have shorter skull lengths than do controls
- short mandible (MGI Ref ID J:123049)
- shortened lower jaw length is statistically significant in females, but not statistically significant in males
- short maxilla (MGI Ref ID J:123049)
- shortened upper jaw length is statistically significant in males, but not statistically significant in females
- decreased bone density (MGI Ref ID J:123049)
- whole body bone mineral density is decreased in both females and males
- hearing/vestibular/ear phenotype
- *normal* hearing/vestibular/ear phenotype (MGI Ref ID J:123049)
- ABR threshold analysis at three months of age indicates normal hearing
- abnormal ear shape (MGI Ref ID J:123049)
- both ears are smaller than normal and have round ear pinnae with ridges around the perimeter
- lowered ear position (MGI Ref ID J:123049)
- respiratory system phenotype
- abnormal nose morphology (MGI Ref ID J:123049)
- females have shorter nose lengths than controls, but the shortened nose lenghts of male homozygotes was not found statistically significant
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Bmp5cfe-se7J | ||
|---|---|---|---|
| Allele Name | cauliflower ear short ear 7 Jackson | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | C.129S7-Gt(ROSA)26Sor/J | ||
| Gene Symbol and Name | Bmp5, bone morphogenetic protein 5 | ||
| Chromosome | 9 | ||
| Gene Common Name(s) | AU023399; MGC34244; expressed sequence AU023399; se; short ear; | ||
| Molecular Note | The cauliflower ear mutation was found to be allelic with the short ear mutation through a noncomplementation test. | ||
| Allele Symbol | Gt(ROSA)26Sor | ||
| Allele Name | gene trap ROSA 26, Philippe Soriano | ||
| Allele Type | Gene trapped | ||
| Common Name(s) | R26tg; ROSA26; ROSA26-lacZ; Rosa26lacZ; TgR(ROSA26)26Sor; gtrosa26; | ||
| Mutation Made By | Philippe Soriano, Mount Sinai School of Medicine | ||
| Strain of Origin | 129S7/SvEvBrd-Hprt1<+> | ||
| ES Cell Line Name | Other (see notes) | ||
| ES Cell Line Strain | 129 | ||
| Site of Expression | All tissues of the developing embryo and in most tissues of the adult mouse. | ||
| Gene Symbol and Name | Gt(ROSA)26Sor, gene trap ROSA 26, Philippe Soriano | ||
| Chromosome | 6 | ||
| Gene Common Name(s) | AV258896; Gtrgeo26; Gtrosa26; R26; ROSA26; beta geo; expressed sequence AV258896; gene trap ROSA 26; gene trap ROSA b-geo 26; | ||
| General Note | ES cell line = AB1 or AB2.1. No overt phenotypes in heterozygous or homozygous animals. The trapped gene appears to be ubiquitously expressed during embryonic development and in all hematopoietic cells. | ||
| Molecular Note | Random insertion of retroviral gene trap vector ROSA, Reverse Orientation with Splice Acceptor, which contains the beta-galactosidase gene and accompanying splice acceptor and neo sequences. The construct was inserted in reverse orientation in the retroviral vector pGen-. The transgene is controlled by an unknown endogenous promoter. lacZ is expressed in all tissues of the developing embryo and in most tissues of the adult transgenic mouse. [MGI Ref ID J:39814] [MGI Ref ID J:79478] | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
References
References
Additional References
Bmp5cfe-se7J relatedGt(ROSA)26Sor relatedGiggey J; Bauschatz J; Curtain M; Donahue LR. 2007. Cauliflower Ear, a Remutation to Bmp5 MGI Direct Data Submission :. [MGI Ref ID J:123049]
Aghi M; Cohen KS; Klein RJ; Scadden DT; Chiocca EA. 2006. Tumor stromal-derived factor-1 recruits vascular progenitors to mitotic neovasculature, where microenvironment influences their differentiated phenotypes. Cancer Res 66(18):9054-64. [PubMed: 16982747] [MGI Ref ID J:112935]
Ahn GO; Brown JM. 2008. Matrix metalloproteinase-9 is required for tumor vasculogenesis but not for angiogenesis: role of bone marrow-derived myelomonocytic cells. Cancer Cell 13(3):193-205. [PubMed: 18328424] [MGI Ref ID J:132946]
Ando S; Abe R; Sasaki M; Murata J; Inokuma D; Shimizu H. 2009. Bone marrow-derived cells are not the origin of the cancer stem cells in ultraviolet-induced skin cancer. Am J Pathol 174(2):595-601. [PubMed: 19131588] [MGI Ref ID J:144196]
Anthony TE; Klein C; Fishell G; Heintz N. 2004. Radial glia serve as neuronal progenitors in all regions of the central nervous system. Neuron 41(6):881-90. [PubMed: 15046721] [MGI Ref ID J:89775]
Arnold SJ; Hofmann UK; Bikoff EK; Robertson EJ. 2008. Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse. Development 135(3):501-11. [PubMed: 18171685] [MGI Ref ID J:131055]
Baba M; Furihata M; Hong SB; Tessarollo L; Haines DC; Southon E; Patel V; Igarashi P; Alvord WG; Leighty R; Yao M; Bernardo M; Ileva L; Choyke P; Warren MB; Zbar B; Linehan WM; Schmidt LS. 2008. Kidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys. J Natl Cancer Inst 100(2):140-54. [PubMed: 18182616] [MGI Ref ID J:130978]
Babaev VR; Yancey PG; Ryzhov SV; Kon V; Breyer MD; Magnuson MA; Fazio S; Linton MF. 2005. Conditional knockout of macrophage PPARgamma increases atherosclerosis in C57BL/6 and low-density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol 25(8):1647-53. [PubMed: 15947238] [MGI Ref ID J:114332]
Bosman EA; Lawson KA; Debruyn J; Beek L; Francis A; Schoonjans L; Huylebroeck D; Zwijsen A. 2006. Smad5 determines murine amnion fate through the control of bone morphogenetic protein expression and signalling levels. Development 133(17):3399-409. [PubMed: 16887830] [MGI Ref ID J:112229]
Carvalho RL; Itoh F; Goumans MJ; Lebrin F; Kato M; Takahashi S; Ema M; Itoh S; van Rooijen M; Bertolino P; Ten Dijke P; Mummery CL. 2007. Compensatory signalling induced in the yolk sac vasculature by deletion of TGF receptors in mice. J Cell Sci 120(Pt 24):4269-77. [PubMed: 18029401] [MGI Ref ID J:128498]
Chi L; Itaranta P; Zhang S; Vainio S. 2006. Sprouty2 is involved in male sex organogenesis by controlling fibroblast growth factor 9-induced mesonephric cell migration to the developing testis. Endocrinology 147(8):3777-88. [PubMed: 16675530] [MGI Ref ID J:129651]
Ciarloni L; Mallepell S; Brisken C. 2007. Amphiregulin is an essential mediator of estrogen receptor alpha function in mammary gland development. Proc Natl Acad Sci U S A 104(13):5455-60. [PubMed: 17369357] [MGI Ref ID J:120116]
Dong F; Sun X; Liu W; Ai D; Klysik E; Lu MF; Hadley J; Antoni L; Chen L; Baldini A; Francis-West P; Martin JF. 2006. Pitx2 promotes development of splanchnic mesoderm-derived branchiomeric muscle. Development 133(24):4891-9. [PubMed: 17107996] [MGI Ref ID J:119660]
Duncan AW; Hickey RD; Paulk NK; Culberson AJ; Olson SB; Finegold MJ; Grompe M. 2009. Ploidy reductions in murine fusion-derived hepatocytes. PLoS Genet 5(2):e1000385. [PubMed: 19229314] [MGI Ref ID J:146785]
Fraidenraich D; Stillwell E; Romero E; Wilkes D; Manova K; Basson CT; Benezra R. 2004. Rescue of cardiac defects in id knockout embryos by injection of embryonic stem cells. Science 306(5694):247-52. [PubMed: 15472070] [MGI Ref ID J:93083]
Friedrich G; Soriano P. 1991. Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev 5(9):1513-23. [PubMed: 1653172] [MGI Ref ID J:79478]
Guerra C; Schuhmacher AJ; Canamero M; Grippo PJ; Verdaguer L; Perez-Gallego L; Dubus P; Sandgren EP; Barbacid M. 2007. Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. Cancer Cell 11(3):291-302. [PubMed: 17349585] [MGI Ref ID J:119988]
Hadland BK; Huppert SS; Kanungo J; Xue Y; Jiang R; Gridley T; Conlon RA; Cheng AM; Kopan R; Longmore GD. 2004. A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development. Blood 104(10):3097-105. [PubMed: 15251982] [MGI Ref ID J:94898]
Haraguchi R; Motoyama J; Sasaki H; Satoh Y; Miyagawa S; Nakagata N; Moon A; Yamada G. 2007. Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling. Development 134(3):525-33. [PubMed: 17202190] [MGI Ref ID J:119913]
Ho KJ; Bass CE; Kroemer AH; Ma C; Terwilliger E; Karp SJ. 2008. Optimized adeno-associated virus 8 produces hepatocyte-specific Cre-mediated recombination without toxicity or affecting liver regeneration. Am J Physiol Gastrointest Liver Physiol 295(2):G412-9. [PubMed: 18535290] [MGI Ref ID J:138633]
Jager R; Maurer J; Jacob A; Schorle H. 2004. Cell type-specific conditional regulation of the c-myc proto-oncogene by combining Cre/loxP recombination and tamoxifen-mediated activation. Genesis 38(3):145-50. [PubMed: 15048812] [MGI Ref ID J:89756]
Kleaveland B; Zheng X; Liu JJ; Blum Y; Tung JJ; Zou Z; Chen M; Guo L; Lu MM; Zhou D; Kitajewski J; Affolter M; Ginsberg MH; Kahn ML. 2009. Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway. Nat Med 15(2):169-76. [PubMed: 19151727] [MGI Ref ID J:146528]
Kobayashi A; Valerius MT; Mugford JW; Carroll TJ; Self M; Oliver G; McMahon AP. 2008. Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development. Cell Stem Cell 3(2):169-81. [PubMed: 18682239] [MGI Ref ID J:148455]
Kohlhepp RL; Hegge LF; Moser AR. 2001. The ROSA26 LacZ-neoR insertion confers resistance to mammary tumors in ApcMin/+ mice. Mamm Genome 12(8):606-11. [PubMed: 11471054] [MGI Ref ID J:70825]
Kohlhepp RL; Hegge LF; Nett JE; Moser AR. 2000. ROSA26 mice carry a modifier of Min-induced mammary and intestinal tumor development. Mamm Genome 11(12):1058-62. [PubMed: 11130972] [MGI Ref ID J:66060]
Kubota H; Avarbock MR; Schmidt JA; Brinster RL. 2009. Spermatogonial stem cells derived from infertile Wv/Wv mice self-renew in vitro and generate progeny following transplantation. Biol Reprod 81(2):293-301. [PubMed: 19369648] [MGI Ref ID J:152976]
Li Z; Chen MJ; Stacy T; Speck NA. 2006. Runx1 function in hematopoiesis is required in cells that express Tek. Blood 107(1):106-10. [PubMed: 16174759] [MGI Ref ID J:125796]
Lugus JJ; Park C; Ma YD; Choi K. 2009. Both primitive and definitive blood cells are derived from Flk-1+ mesoderm. Blood 113(3):563-6. [PubMed: 18957687] [MGI Ref ID J:144056]
Macatee TL; Hammond BP; Arenkiel BR; Francis L; Frank DU; Moon AM. 2003. Ablation of specific expression domains reveals discrete functions of ectoderm- and endoderm-derived FGF8 during cardiovascular and pharyngeal development. Development 130(25):6361-74. [PubMed: 14623825] [MGI Ref ID J:87304]
Matsumoto Y; Irie F; Inatani M; Tessier-Lavigne M; Yamaguchi Y. 2007. Netrin-1/DCC signaling in commissural axon guidance requires cell-autonomous expression of heparan sulfate. J Neurosci 27(16):4342-50. [PubMed: 17442818] [MGI Ref ID J:121105]
Matt N; Dupe V; Garnier JM; Dennefeld C; Chambon P; Mark M; Ghyselinck NB. 2005. Retinoic acid-dependent eye morphogenesis is orchestrated by neural crest cells. Development 132(21):4789-800. [PubMed: 16207763] [MGI Ref ID J:102847]
Medina-Martinez O; Amaya-Manzanares F; Liu C; Mendoza M; Shah R; Zhang L; Behringer RR; Mahon KA; Jamrich M. 2009. Cell-autonomous requirement for rx function in the mammalian retina and posterior pituitary. PLoS ONE 4(2):e4513. [PubMed: 19229337] [MGI Ref ID J:146279]
Morroni M; Giordano A; Zingaretti MC; Boiani R; De Matteis R; Kahn BB; Nisoli E; Tonello C; Pisoschi C; Luchetti MM; Marelli M; Cinti S. 2004. Reversible transdifferentiation of secretory epithelial cells into adipocytes in the mammary gland. Proc Natl Acad Sci U S A 101(48):16801-6. [PubMed: 15556998] [MGI Ref ID J:94729]
Mukouyama YS; Deneen B; Lukaszewicz A; Novitch BG; Wichterle H; Jessell TM; Anderson DJ. 2006. Olig2+ neuroepithelial motoneuron progenitors are not multipotent stem cells in vivo. Proc Natl Acad Sci U S A 103(5):1551-6. [PubMed: 16432183] [MGI Ref ID J:142333]
Narhi K; Jarvinen E; Birchmeier W; Taketo MM; Mikkola ML; Thesleff I. 2008. Sustained epithelial {beta}-catenin activity induces precocious hair development but disrupts hair follicle down-growth and hair shaft formation. Development 135(6):1019-28. [PubMed: 18256193] [MGI Ref ID J:131961]
Nguyen QT; Son YJ; Sanes JR; Lichtman JW. 2000. Nerve terminals form but fail to mature when postsynaptic differentiation is blocked: in vivo analysis using mammalian nerve-muscle chimeras. J Neurosci 20(16):6077-86. [PubMed: 10934257] [MGI Ref ID J:120388]
Nishimura EK; Jordan SA; Oshima H; Yoshida H; Osawa M; Moriyama M; Jackson IJ; Barrandon Y; Miyachi Y; Nishikawa S. 2002. Dominant role of the niche in melanocyte stem-cell fate determination. Nature 416(6883):854-60. [PubMed: 11976685] [MGI Ref ID J:130556]
Okamura Y; Saga Y. 2008. Notch signaling is required for the maintenance of enteric neural crest progenitors. Development 135(21):3555-65. [PubMed: 18832397] [MGI Ref ID J:143441]
Parisi T; Bronson RT; Lees JA. 2009. Inhibition of pituitary tumors in Rb mutant chimeras through E2f4 loss reveals a key suppressive role for the pRB/E2F pathway in urothelium and ganglionic carcinogenesis. Oncogene 28(4):500-8. [PubMed: 18997819] [MGI Ref ID J:145896]
Patel V; Li L; Cobo-Stark P; Shao X; Somlo S; Lin F; Igarashi P. 2008. Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia. Hum Mol Genet 17(11):1578-90. [PubMed: 18263895] [MGI Ref ID J:135523]
Que J; Wilm B; Hasegawa H; Wang F; Bader D; Hogan BL. 2008. Mesothelium contributes to vascular smooth muscle and mesenchyme during lung development. Proc Natl Acad Sci U S A 105(43):16626-30. [PubMed: 18922767] [MGI Ref ID J:143278]
R R; Speed R; Taggart M; Cooke HJ. 2003. Spermatogenesis in testes of Dazl null mice after transplantation of wild-type germ cells. Reproduction 126(5):599-604. [PubMed: 14611632] [MGI Ref ID J:87151]
Samokhvalov IM; Samokhvalova NI; Nishikawa S. 2007. Cell tracing shows the contribution of the yolk sac to adult haematopoiesis. Nature 446(7139):1056-61. [PubMed: 17377529] [MGI Ref ID J:121435]
Sasaki T; Ito Y; Xu X; Han J; Bringas P Jr; Maeda T; Slavkin HC; Grosschedl R; Chai Y. 2005. LEF1 is a critical epithelial survival factor during tooth morphogenesis. Dev Biol 278(1):130-43. [PubMed: 15649466] [MGI Ref ID J:96501]
Seandel M; James D; Shmelkov SV; Falciatori I; Kim J; Chavala S; Scherr DS; Zhang F; Torres R; Gale NW; Yancopoulos GD; Murphy A; Valenzuela DM; Hobbs RM; Pandolfi PP; Rafii S. 2007. Generation of functional multipotent adult stem cells from GPR125+ germline progenitors. Nature 449(7160):346-50. [PubMed: 17882221] [MGI Ref ID J:126330]
Sebzda E; Hibbard C; Sweeney S; Abtahian F; Bezman N; Clemens G; Maltzman JS; Cheng L; Liu F; Turner M; Tybulewicz V; Koretzky GA; Kahn ML. 2006. Syk and Slp-76 mutant mice reveal a cell-autonomous hematopoietic cell contribution to vascular development. Dev Cell 11(3):349-61. [PubMed: 16950126] [MGI Ref ID J:112805]
Shi Y; Desponts C; Do JT; Hahm HS; Scholer HR; Ding S. 2008. Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell 3(5):568-74. [PubMed: 18983970] [MGI Ref ID J:149867]
Snider P; Fix JL; Rogers R; Peabody-Dowling G; Ingram D; Lilly B; Conway SJ. 2008. Generation and characterization of Csrp1 enhancer-driven tissue-restricted Cre-recombinase mice. Genesis 46(3):167-76. [PubMed: 18327771] [MGI Ref ID J:133342]
Takahashi Y; Kitajima S; Inoue T; Kanno J; Saga Y. 2005. Differential contributions of Mesp1 and Mesp2 to the epithelialization and rostro-caudal patterning of somites. Development 132(4):787-96. [PubMed: 15677726] [MGI Ref ID J:120635]
Tanaka KK; Hall JK; Troy AA; Cornelison DD; Majka SM; Olwin BB. 2009. Syndecan-4-expressing muscle progenitor cells in the SP engraft as satellite cells during muscle regeneration. Cell Stem Cell 4(3):217-25. [PubMed: 19265661] [MGI Ref ID J:149919]
Vernet N; Dennefeld C; Guillou F; Chambon P; Ghyselinck NB; Mark M. 2006. Prepubertal testis development relies on retinoic acid but not rexinoid receptors in Sertoli cells. EMBO J 25(24):5816-25. [PubMed: 17124491] [MGI Ref ID J:119926]
Vidal A; Zacharoulis S; Guo W; Shaffer D; Giancotti F; Bramley AH; de la Hoz C; Jensen KK; Kato D; MacDonald DD; Knowles J; Yeh N; Frohman LA; Rafii S; Lyden D; Koff A. 2005. p130Rb2 and p27kip1 cooperate to control mobilization of angiogenic progenitors from the bone marrow. Proc Natl Acad Sci U S A 102(19):6890-5. [PubMed: 15867156] [MGI Ref ID J:99064]
Wijgerde M; McMahon JA; Rule M; McMahon AP. 2002. A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord. Genes Dev 16(22):2849-64. [PubMed: 12435628] [MGI Ref ID J:80206]
Yamamoto S; Fukumoto E; Yoshizaki K; Iwamoto T; Yamada A; Tanaka K; Suzuki H; Aizawa S; Arakaki M; Yuasa K; Oka K; Chai Y; Nonaka K; Fukumoto S. 2008. Platelet-derived growth factor receptor regulates salivary gland morphogenesis via fibroblast growth factor expression. J Biol Chem 283(34):23139-49. [PubMed: 18559345] [MGI Ref ID J:140258]
Ybot-Gonzalez P; Savery D; Gerrelli D; Signore M; Mitchell CE; Faux CH; Greene ND; Copp AJ. 2007. Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure. Development 134(4):789-99. [PubMed: 17229766] [MGI Ref ID J:119920]
Zambrowicz BP; Imamoto A; Fiering S; Herzenberg LA; Kerr WG; Soriano P. 1997. Disruption of overlapping transcripts in the ROSA beta geo 26 gene trap strain leads to widespread expression of beta-galactosidase in mouse embryos and hematopoietic cells. Proc Natl Acad Sci U S A 94(8):3789-94. [PubMed: 9108056] [MGI Ref ID J:39814]
Zhang C; Wu B; Beglopoulos V; Wines-Samuelson M; Zhang D; Dragatsis I; Sudhof TC; Shen J. 2009. Presenilins are essential for regulating neurotransmitter release. Nature 460(7255):632-6. [PubMed: 19641596] [MGI Ref ID J:150936]
Zhang Z; Cerrato F; Xu H; Vitelli F; Morishima M; Vincentz J; Furuta Y; Ma L; Martin JF; Baldini A; Lindsay E. 2005. Tbx1 expression in pharyngeal epithelia is necessary for pharyngeal arch artery development. Development 132(23):5307-15. [PubMed: 16284121] [MGI Ref ID J:102843]
Health & husbandry
Health & Colony Maintenance Information
Currently there no information available for this strain. This may be due to the supply level of this strain.
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
|
Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
| Pricing for International shipping destinations |
|
Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
|
|
|
Supply Details
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
|
| Important Note | |
| This strain is segregating for Gt(ROSA)26Sor. | |
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
Purchasing Information
JAX® Mice Orders
Surgical Services
Contact Information
Orders & Technical Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form
Terms of Use
Terms of Use
General Terms and Conditions
For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license.
Contact information
General inquiries
Contracts Administration
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. In purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.