Strain Name:

CBy;B6-Bmp5cfe-se8J/J

Stock Number:

005421

Availability:

Repository-Cryopreserved

Description

Strain Information

Type Chemically Induced Mutation; Mutant Stock; Spontaneous Mutation;
Specieslaboratory mouse

Development
The cauliflower ear 8 Jackson re-mutation of Bmp5 arose in the offspring of an ENU mutagenized C57BL/6J male, which was then bred to a BALB/cByJ female. The mutant line was maintained segregating on this mixed background and in 2006 embryos were generated for cryopreservation using homozygous males and BALB/cByJ females.

Related Strains

Strains carrying other alleles of Bmp5
000004   ABP/LeJ
000578   B6 x STOCK Tyrc-ch Bmp5se +/+ Myo6sv/J
000056   B6.Cg-Bmp5se/J
000285   B6.Cg-Rorasg + +/+ Myo5ad Bmp5se/J
001496   C57BL/6J-Bmp5se-4J/J
005420   C;129S7 Gt(ROSA)26Sor-Bmp5cfe-se7J/J
000253   DLS/LeJ
000644   SEA/GnJ
000270   SEC/1GnLeJ
View Strains carrying other alleles of Bmp5     (9 strains)

Phenotype

Phenotype Information

Mammalian Phenotype Terms assigned by genotype

Bmp5cfe-se8J/Bmp5cfe-se8J

        involves: BALB/cByJ * C57BL/6J
  • craniofacial phenotype
  • abnormal ear shape (MGI Ref ID J:123125)
    • ears have ruffles around the perimeter of the ear pinnae
  • small ears (MGI Ref ID J:123125)
    • ears are smaller than normal
  • hearing/vestibular/ear phenotype
  • abnormal ear shape (MGI Ref ID J:123125)
    • ears have ruffles around the perimeter of the ear pinnae
  • small ears (MGI Ref ID J:123125)
    • ears are smaller than normal
  • skeleton phenotype
  • *normal* skeleton phenotype (MGI Ref ID J:123125)
    • As is the case with cfe-se7J homozygotes, X-Ray fails to detect the skeletal defects found in other mutants of this gene

Genes & Alleles

Gene & Allele Information

Allele Symbol Bmp5cfe-se8J
Allele Name cauliflower ear short ear 8 Jackson
Strain of OriginC57BL/6J
Gene Symbol and Name Bmp5, bone morphogenetic protein 5
Chromosome 9
Gene Common Name(s) AU023399; MGC34244; expressed sequence AU023399; se; short ear;
Molecular Note A failed complementation test with cfe-7J proved that this is an allele of Bmp5.

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Optimizing PCR Protocols

References

References

Selected Reference(s)

Giggey J; Bauschatz J; Curtain M; Hurd J; Donahue LR. 2007. A Cauliflower Remutation to Bmp-5 MGI Direct Data Submission :.  [MGI Ref ID J:123125]

Health & husbandry

Health & Colony Maintenance Information

Currently there no information available for this strain. This may be due to the supply level of this strain.

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations             View   International   Pricing
Weeks of AgePrice*Gender
Cryorecovery Fee $1900.00
Cryopreserved Embryos Fee $1600.00
*Price(s) in US dollars ($)

Supply Details

Standard SupplyRepository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes
  • Cryopreserved Embryos
    This strain is also available as cryopreserved embryos from our Repository. Orders for cryopreserved embryos are supplied subject to a signed agreement that must be returned to the Customer Service Department after order placement. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos from our repository, please visit our Cryopreserved Embryos web page.
  • Cryorecovery - Standard.
    The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 or 1-207-288-5845.

  • Genomic DNA is available for this strain from the Mouse DNA Resource.

Pricing for International shipping destinations             View   USA, Canada and Mexico   Pricing
Weeks of AgePrice*Gender
Cryorecovery Fee $2470.00
Cryopreserved Embryos Fee $2080.00
*Price(s) in US dollars ($)

Supply Details

Standard SupplyRepository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes
  • Cryopreserved Embryos
    This strain is also available as cryopreserved embryos from our Repository. Orders for cryopreserved embryos are supplied subject to a signed agreement that must be returned to the Customer Service Department after order placement. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos from our repository, please visit our Cryopreserved Embryos web page.
  • Cryorecovery - Standard.
    The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 or 1-207-288-5845.

  • Genomic DNA is available for this strain from the Mouse DNA Resource.

General Terms and Conditions

View JAX® Mice & Services Conditions of Use.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering and Purchasing Information

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Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
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