Description

Strain Information

Former Names C57BL/6J-Clcn1nmf355/J    (Changed: 22-MAY-06 ) C57BL/6J-nmf355/J    (Changed: 05-JAN-06 ) Type Chemically Induced Mutation; Coisogenic; Mutant Strain; Additional information on Genetically Engineered Mutant Mice. Species laboratory mouse H2 Haplotype b Generation N2F2+N1p (04-SEP-05)

Appearance
black, affected
Related Genotype: a/a, Clcn1^adr-mto7J/Clcn1^adr-mto7J

black, unaffected
Related Genotype: a/a, Clcn1^adr-mto7J/+ or a/a, +/+

Description
View strain phenotype and additional information on the Neuroscience Mutagenesis Facility web page for Clcn1^adr-mto7J entry.

Control Information

	Control
	+/? untyped from the colony
Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of Clcn1

003817	B6;129S-Fcgr2btm1Ttk Clcn1adr-mto5J/J
003922	BALB/cByJ-Clcn1adr-mto2J jgl/J
001265	BALB/cByJ-Clcn1adr-mto2J/J
005253	C57BL/6J-Clcn1adr-mto6J/J
008253	C57BL/6J-Clcn1adr-mto9J/J
000939	SWR/J-Clcn1adr-mto/J

View Strains carrying other alleles of Clcn1     (6 strains)

Additional Web Information

Genetic Quality Control Annual Report

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms

      assigned by genotype

Clcn1^adr-mto7J/Clcn1^adr-mto7J

        C57BL/6J-Clcn1^adr-mto7J/J

• behavior/neurological phenotype
• limb grasping (MGI Ref ID J:82238)
  • from approximately 4 weeks of age, mutant mice draw their hind limbs close to the body when picked up by the tail and fail to withdraw a hind limb that is gently pulled
• muscle phenotype
• muscle spasm (MGI Ref ID J:82238)
  • from approximately 4 weeks of age, mutant mice exhibit hind limb spasms; mild spasms cause apparently hesitant movement, while intense spasms can persist longer than 2 seconds and cause the limb either to be drawn close to the body or extended backward or to the side

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Clcn1^adr-mto7J related

Cell Biology Research
Channel and Transporter Defects (chloride)

Neurobiology Research
Ataxia (Movement) Defects
Channel and Transporter Defects (chloride)
Neuroscience Mutagenesis Facility Strain

Genes & Alleles

Gene & Allele Information

Allele Symbol		Clcn1adr-mto7J
Allele Name		myotonia 7 Jackson
Allele Type		Chemically induced (ENU)
Common Name(s)		Clcn1nmf355; NMF355; neuroscience mutagenesis facility, 355;
Strain of Origin		C57BL/6J
Gene Symbol and Name		Clcn1, chloride channel 1
Chromosome		6
Gene Common Name(s)		CLC1; Clc-1; Clc1; MGC138361; MGC142055; NMF355; SMCC; SMCC1; adr; arrested development of righting response; mto; myotonia; neuroscience mutagenesis facility, 355; nmf310; nmf355;
Molecular Note		This phenotypic allele was identified in an ENU mutagenesis screen. It was shown by its failure to complement Clcn1adr-mto2J to be an allele of Clcn1.

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Optimizing PCR Protocols

References

References

Additional References

Clcn1^adr-mto7J related

JAX Neuroscience Mutagenesis Facility URL: http://www.jax.org/nmf. 2003. Heritable mouse mutants from JAX NMF ENU Mutagenesis Program MGI Direct Data Submission :.  [MGI Ref ID J:82238]

Health & husbandry

Health & Colony Maintenance Information

Currently there no information available for this strain. This may be due to the supply level of this strain.

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Supply Details

Standard Supply

Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.

Supply Notes

Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 or 1-207-288-5845. This strain is included in the Neuroscience Mutagenesis Facility (NMF).

Control Information

	Control
	+/? untyped from the colony
Considerations for Choosing Controls
USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
International - Control Pricing Information for Genetically Engineered Mutant Strains.

General Terms and Conditions

See Terms of Use

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Ordering and Purchasing Information

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Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form

Terms of Use

Terms of Use

General Terms and Conditions

Contact information

General inquiries

Contracts Administration

phone:	207-288-6470
fax:	207-288-6655

JAX^® Mice & Services Conditions of Use

“Each recipient institution, including its employees and other researchers under its control (RECIPIENT), of mice or services using mice from The Jackson Laboratory (TJL) agrees that such mice, descendants of those mice derived by inbreeding or crossbreeding, including unmodified derivatives of those mice or their descendants (“MICE”) shall not be: (i) used for any purpose other than the internal research of the RECIPIENT, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services with respect to MICE. Acceptance of MICE from TJL shall be deemed agreement by RECIPIENT to these conditions, and departure from these conditions requires The Jackson Laboratory’s prior written authorization.”

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The foregoing represents the General Terms and Conditions applicable to The Jackson Laboratory’s MICE, products and services. In addition, special terms and conditions of sale of certain MICE, products and services may be set forth separately in The Jackson Laboratory web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, products and services by The Jackson Laboratory, and by its licensees and distributors.

Acceptance of delivery of MICE, products or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on The Jackson Laboratory, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, products services by The Jackson Laboratory.