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Strain Name:

C57BL/6J-Myo7ash1-11J/J

Stock Number:

005468

Availability:

Repository-Cryopreserved

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General Terms and Conditions

Former Name      C57BL/6J-Myo7anmf371/J    (Changed: 22-MAY-06 )
      C57BL/6J-nmf371/J    (Changed: 23-NOV-05 )
Strain Common Names      NMF371;
Genes & Alleles   Myo7a;   Myo7ash1-11J;

Product Information

Strain Details

Type JAX® GEMM® Strain - Chemically Induced Mutation
Additional information on JAX® GEMM® Strains.
Type JAX® GEMM® Strain - Coisogenic
Type JAX® GEMM® Strain - Mutant Strain
Specieslaboratory mouse
H2 Haplotypeb

Appearance
black
Related Genotype: a/a

Strain Description
View strain phenotype and additional information on the Neuroscience Mutagenesis Facility web page for Myo7ash1-11J entry.

Mammalian Phenotype Terms assigned by genotype

Myo7ash1-11J/Myo7ash1-11J

        C57BL/6J-Myo7ash1-11J/J
  • behavior/neurological phenotype
  • circling (MGI Ref ID J:82238)
    • mutant mice exhibit bidirectional circling behavior from weaning age, at approximately 3-4 weeks
  • head tilt (MGI Ref ID J:82238)
    • mutants exhibit a head tilt from weaning age, approximately 3-4 weeks
  • hearing/vestibular/ear phenotype
  • circling (MGI Ref ID J:82238)
    • mutant mice exhibit bidirectional circling behavior from weaning age, at approximately 3-4 weeks
  • head tilt (MGI Ref ID J:82238)
    • mutants exhibit a head tilt from weaning age, approximately 3-4 weeks

Gene & Allele Details

Allele Symbol Myo7ash1-11J
Allele Name shaker 1, 11 Jackson
Common Name(s) Myo7anmf371; NMF371; neuroscience mutagenesis facility, 371;
Strain of OriginC57BL/6J
Gene Symbol and Name Myo7a, myosin VIIa
Chromosome 7
Gene Common Name(s) DFNA11; DFNB2; MYOVIIA; MYU7A; Myo7; NSRD2; USH1B; myosin VII; neuroscience mutagenesis facility, 371; nmf371; sh-1; sh1; shaker 1;
Molecular Note This phenotypic mutation was identified in an ENU mutagenesis screen. [MGI Ref ID J:82238]

Control Information

  Control
   +/? untyped from the colony
 
  Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of Myo7a
003184   B6.Cg-Myo7ash1-8J/J
000619   FS/EiJ
000271   SH1/LeJ
002919   STOCK Myo7ash1-7J/J
View Strains carrying other alleles of Myo7a     (4 strains)

Additional Web Information

Genetic Quality Control Annual Report

Research Applications

This mouse can be used to support research in many areas including:

Myo7ash1-11J related

Neurobiology Research
Ataxia (Movement) Defects
Neuroscience Mutagenesis Facility Strain
Vestibular and Hearing Defects

Sensorineural Research
Vestibular and Hearing Defects

References

Additional References

Price and Supply Information

Strain Name: C57BL/6J-Myo7ash1-11J/J
Stock Number: 005468

Price Details

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Supply Details

Standard SupplyRepository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes Cryorecovery - Standard.
The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery.

Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services: Tel: 1-800-422-6423 or 1-207-288-5845; Email: jaxservices@jax.org.
This strain is included in the Neuroscience Mutagenesis Facility (NMF).
Genomic DNA is available for this strain from the Mouse DNA Resource.

LicensingSee General Terms and Conditions below  
Control InformationView Control Information in Strain Details.

General Terms and Conditions

View JAX® Mice & Services Conditions of Use.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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Contact Information
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