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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Former Names C3.129S1(B6)-rcw/J (Changed: 14-DEC-07 ) Type Congenic; Mutant Strain; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Background Strain C3H (see Development Field) Donor Strain 129S1/SvImJ H2 Haplotype k Generation N5F2+N1p (31-OCT-05) Important Note
This strain is homozygous for the retinal degeneration mutation Pde6brd1; it may also carry the age related hearing loss mutation, Cdh23ahl, which is linked to rcw within ~20 - 30 cM on Chromosome 10.Description
Visibly, Grm1rcw/Grm1rcw mice are identifiable by 2.5 - 3 weeks of age. Their constant wobbly gait frequently throws them off balance, but only briefly, as they show immediate and normal righting response. When walking, they often brace for balance with their fore- and hindfeet extended forward or sideways. Their heads lurch mildly and the mutants often sit on their haunches when motion falters. Their forefeet show normal grip strength when the mutant mice are pulled gently backwards over a cage cover. When picked up by the tail, they may clasp their hindfeet. However, they show sufficient hindlimb strength to prevent their falling when placed on an edge. Mutants live through adulthood, and mice of both sexes breed. Grm1rcw has been mapped between the flanking markers D10Mit49, at map position 6.3 Mb and D10Mit80, at map position 11.4 Mb.Development
rcw arose in the 129S1/SvImJ production colony at The Jackson Laboratory in 1998. An affected female was crossed to a C3HeB/FeJ male, and the stock was then maintained by sib matings for seven generations. It was then decided to transfer rcw onto C3FeLe.B6-a/a so that females of an agouti C3H subline could serve as ovarian transplant hosts if ovarian transplantation should prove necessary to maintain the mutation on an inbred background. The resulting strain was named C3FeLe.Cg a-rcw/J. This strain is no longer available. The homozygous mutant phenotype did not diminish or show reduced viability at N5. In 2005 embryos were generated for cryopreservation using C3HeB/FeJ agouti females and congenic C3FeLe.B6-a/a homozygous mutant males and were assigned stock#5494 and named C3.Cg-rcw/J. This thawed strain will be segregating for a and A.
Related Strains
Strains carrying Cdh23ahl allele
001137 129P1/ReJ 000690 129P3/J 000691 129X1/SvJ 000646 A/J 000647 A/WySnJ 003070 ALR/LtJ 003072 ALS/LtJ 004502 B6;AKR-Lxl2/GrsrJ 001026 BALB/cByJ 000653 BUB/BnJ 000664 C57BL/6J 004764 C57BL/6J-Cdh23v-8J/J 003129 C57BL/6J-Epha4rb-2J/GrsrJ 004820 C57BL/6J-Kcne12J/J 004703 C57BL/6J-Kcnq2Nmf134/J 004811 C57BL/6J-nmf110/J 004812 C57BL/6J-nmf111/J 004747 C57BL/6J-nmf118/J 004656 C57BL/6J-nmf88/J 004391 C57BL/6J-Chr 13A/J/NaJ 004385 C57BL/6J-Chr 7A/J/NaJ 000662 C57BLKS/J 000667 C57BR/cdJ 000668 C57L/J 000669 C58/J 000657 CE/J 000670 DBA/1J 001140 DBA/1LacJ 000671 DBA/2J 007048 DBA/2J-Gpnmb+/SjJ 002106 KK/HlJ 000675 LG/J 000676 LP/J 000677 MA/MyJ 001976 NOD/ShiLtJ 002050 NOR/LtJ 000679 P/J 002747 SENCARB/PtJ 002335 SKH2/J 003392 STOCK Crb1rd8/J View Strains carrying Cdh23ahl (40 strains)
002756 B6.CAST-Cdh23Ahl+/Kjn 002432 B6J x B6.C-H2-Kbm1/ByJ-Cdh23v-J/J 002552 C57BL/6J-Cdh23v-2J/J 004764 C57BL/6J-Cdh23v-8J/J 004819 C57BL/6J-Cdh23v-9J/J 005016 CByJ;B6-Cdh23v-10J/J 000275 V/LeJ
005814 B6.129P2-Grm1tm1Dgen/J 005561 C57BL/6J-Grm1nmf373/J 005521 C57BL/6J-Grm1rcw-3J/GrsrJ
004297 B6.CXB1-Pde6brd10/J 003647 B6EiC3Sn.BLiAF1 002802 C3.BLiA Pde6b+-Krd/J 001979 C3A.BLiA-Pde6b+.O20-Prph2Rd2/J 001912 C3A.BLiA-Pde6b+/J 003648 C3Sn.BLiA-Pde6b+/Dn 004766 C57BL/6J-Pde6brd1-2J/J 004828 FVB.129P2-Pde6b+ Tyrc-ch/AntJ 004808 STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Grm1rcw/Grm1rcw
129S1/SvImJ
- behavior/neurological phenotype
- abnormal gait (MGI Ref ID J:83427)
- mutants exhibit a constant wobbly gait
- impaired balance (MGI Ref ID J:83427)
- an animal can throw itself off balance but only briefly (normal righting response); mutants brace for balance with fore- and hindfeet extended to front and sides and may sit on haunches; often mild lurching back and forth with head trying to get body in motion; normal grip with forefeet
- limb grasping (MGI Ref ID J:83427)
- animals may clench hindfeet when picked up by tail and holds onto an edge by doing so
This mouse can be used to support research in many areas including:Cdh23ahl related
Grm1rcw relatedNeurobiology Research
Vestibular and Hearing Defects
Age related hearing loss
Sensorineural Research
Vestibular and Hearing Defects
Age related hearing loss
Pde6brd1 relatedNeurobiology Research
Ataxia (Movement) Defects
Mouse/Human Gene Homologs
retinitis pigmentosa, autosomal recessive
Sensorineural Research
Retinal Degeneration
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Grm1rcw | ||
|---|---|---|---|
| Allele Name | recoil wobbler | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | 129S1/SvImJ | ||
| Gene Symbol and Name | Grm1, glutamate receptor, metabotropic 1 | ||
| Chromosome | 10 | ||
| Gene Common Name(s) | 4930455H15Rik; G protein coupled receptor, family C, group 1, member A; G protein-coupled receptor, family C, group 1, member A; GPRC1A; GRM1A; Gprc1a; MGLUR1; MGLUR1A; RIKEN cDNA 4930455H15 gene; mGlu1; neuroscience mutagenesis facility, 373; nmf373; rcw; recoil wobbler; wobbles; wobl; | ||
| Molecular Note | A spontaneous mutation that arose at The Jackson Laboratory. A G1251T transversion causing an E292D amino acid change has been identified. [MGI Ref ID J:127311] | ||
| Allele Symbol | Cdh23ahl | ||
| Allele Name | age related hearing loss 1 | ||
| Allele Type | QTL | ||
| Common Name(s) | Cdh23753A; mdfw; | ||
| Allele Symbol | Pde6brd1 | ||
| Allele Name | retinal degeneration 1 | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | Pdebrd1; rd; rd-1; rd1; rodless retina; | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
References
References
Additional References
Grm1rcw relatedCook SA; Bronson RT; Davisson MT. 2003. A new neurological mutation in the proximal region of mouse Chromosome 10. Mouse Mutant Resources Web Site, The Jackson Laboratory, Bar Harbor, Maine (http://www.jax.org/mmr) MGI Direct Data Submission :. [MGI Ref ID J:83427]
Sachs AJ; Schwendinger JK; Yang AW; Haider NB; Nystuen AM. 2007. The mouse mutants recoil wobbler and nmf373 represent a series of Grm1 mutations. Mamm Genome 18(11):749-56. [PubMed: 17934773] [MGI Ref ID J:127311]
Health & husbandry
Health & Colony Maintenance Information
Currently there no information available for this strain. This may be due to the supply level of this strain.
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 Cryopreserved Embryos $1600.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
| Pricing for International shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 Cryopreserved Embryos $2080.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
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Supply Details
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
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| Supply Notes |
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| Important Note | |
| This strain is homozygous for the retinal degeneration mutation Pde6brd1; it may also carry the age related hearing loss mutation, Cdh23ahl, which is linked to rcw within ~20 - 30 cM on Chromosome 10. | |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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