Strain Name: |
C57BL/6J-mtA/J/NaJ |
|---|---|
Stock Number: |
005545 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Former Name |
C57BL/6J-mtA/NaJ (Changed: 16-NOV-05
) |
Product Information
Strain Details
Type Conplastic Type JAX® GEMM® Strain - Mutant Strain Additional information on JAX® GEMM® Strains. Species laboratory mouse Background Strain C57BL/6J Donor Strain A/J H2 Haplotype b Generation N14F3p Appearance
black
Related Genotype: a/aStrain Description
A chromosome substitution or consomic strain is an inbred strain with one of its chromosomes replaced by the homologous chromosome of another inbred strain. The C57BL/6J and A/J strains in this set were chosen because they differ in their susceptibility to diseases such as arthritis, asthma, atherosclerosis, cancer, several infectious diseases, inflammatory responses, and physiological, behavioral and sensory phenotypes. Chromosome substitution strain nomenclature is designated as Host Strain - Chromosome #<Donor Strain>/Laboratory code. For example, C57BL/6J-Chr1A/NaJ carries chromosome 1 for strain A/J (A) on a C57BL/6J background, was constructed in the laboratory of Joseph Nadeau (Na) and is maintained at The Jackson Laboratory (J). Chromosome substitution strains or consomic strains can accelerate quantitative trait loci identification and mapping.Strain Development
Dr. Joseph Nadeau from Case Western Reserve University developed the C57BL/6J-Chr #A/NaJ strain set by replacing individual chromosomes from the A/J donor strain into the C57BL/6J host strain using a marker-assisted series of backcrosses (Nadeau et al., 2000). A mitochondrial substitution or conplastic strain is created by performing the initial backcross with a female donor, then using F1 females and females of all subsquent generations for further backcrosses to the male host. The set was donated to The Jackson Laboratory in 2004.
Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
B6/A Consomic Panel
004388 C57BL/6J-Chr 10A/J/NaJ 004389 C57BL/6J-Chr 11A/J/NaJ 004390 C57BL/6J-Chr 12A/J/NaJ 004391 C57BL/6J-Chr 13A/J/NaJ 004392 C57BL/6J-Chr 14A/J/NaJ 004393 C57BL/6J-Chr 15A/J/NaJ 004394 C57BL/6J-Chr 16A/J/NaJ 004395 C57BL/6J-Chr 17A/J/NaJ 004396 C57BL/6J-Chr 18A/J/NaJ 004397 C57BL/6J-Chr 19A/J/NaJ 004379 C57BL/6J-Chr 1A/J/NaJ 004380 C57BL/6J-Chr 2A/J/NaJ 004381 C57BL/6J-Chr 3A/J/NaJ 004382 C57BL/6J-Chr 4A/J/NaJ 004383 C57BL/6J-Chr 5A/J/NaJ 004384 C57BL/6J-Chr 6A/J/NaJ 004385 C57BL/6J-Chr 7A/J/NaJ 004386 C57BL/6J-Chr 8A/J/NaJ 004398 C57BL/6J-Chr XA/J/NaJ 004399 C57BL/6J-Chr YA/J/NaJ View B6/A Consomic Panel (20 strains)
Additional Web Information
Genetic Quality Control Annual Report
JAX Notes, Spring 2004; 493. Chromosome Substitution Strain Panel: A New Tool for Quantitative Trait Loci Analysis.
Research Applications
This mouse can be used to support research in many areas including:
Research Tools
Genetics Research (Gene Mapping: Tools for QTL Mapping, Segregation and Linkage Analysis)
Price and Supply Information
| Strain Name: | C57BL/6J-mtA/J/NaJ |
| Stock Number: | 005545 |
Price Details
IMPORTANT NOTE: Prices are based on shipping destination. To view prices, select your shipping destination.
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to the Supply Notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Licensing | See General Terms and Conditions below for Licensing and Use Restrictions |
| Control Information | View Control Information in Strain Details. |
General Terms and Conditions
View JAX® Mice & Services Conditions of Use.
For additional Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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