Description

Strain Information

Type Mutant Strain; Spontaneous Mutation; Additional information on Genetically Engineered Mutant Mice. Species laboratory mouse Generation +F18+N1F3 (06-DEC-07)

Development
The ruby-eye 7 Jackson mutation arose spontaneously in the B6.129S4-Cd86^tm1Shr/J strain (stock #003609). This mutant subline was backcrossed once to C57BL/6J and selectively intercrossed to bred out the targeted mutation and this strain has been maintained subsequently by sibling mating.

Control Information

	Control
	Heterozygote from the colony
Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of Hps6

002424	B6 x C3H/HeJ-Hps6ru-6J/J
000103	B6.Cg-Hps6ru/J
006929	B6.Cg-Hps6ru/JLlp
000278	B6C3Fe a/a-Papss2bm Hps1ep Hps6ru/J
000259	JE/LeJ

View Strains carrying other alleles of Hps6     (5 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms

      assigned by genotype

Hps6^ru-7J/Hps6^ru-7J

        involves: 129S4/SvJae * C57BL/6

• craniofacial phenotype
• abnormal ear pigmentation (MGI Ref ID J:133644)
  • severe loss of pigment in the ear skin
• hearing/vestibular/ear phenotype
• *normal* hearing/vestibular/ear phenotype (MGI Ref ID J:133644)
  • auditory brainstem response is normal
• abnormal ear pigmentation (MGI Ref ID J:133644)
  • severe loss of pigment in the ear skin
• pigmentation phenotype
• abnormal ear pigmentation (MGI Ref ID J:133644)
  • severe loss of pigment in the ear skin
• diluted coat color (MGI Ref ID J:133644)
  • grey coat color
• reduced eye pigmentation (MGI Ref ID J:133644)
  • ruby colored eyes
• skin/coat/nails phenotype
• abnormal ear pigmentation (MGI Ref ID J:133644)
  • severe loss of pigment in the ear skin
• diluted coat color (MGI Ref ID J:133644)
  • grey coat color
• vision/eye phenotype
• reduced eye pigmentation (MGI Ref ID J:133644)
  • ruby colored eyes

Genes & Alleles

Gene & Allele Information

Allele Symbol		Hps6ru-7J
Allele Name		ruby-eye 7 Jackson
Allele Type		Spontaneous
Strain of Origin		B6.129S4-Cd86tm1Shr/J
Gene Symbol and Name		Hps6, Hermansky-Pudlak syndrome 6
Chromosome		19
Gene Common Name(s)		5330434M19Rik; BLOC-2; FLJ22501; Hsp6; MGC20522; MGC93064; RIKEN cDNA 5330434M19 gene; RP11-302K17.1; ru; ruby eye; ruby-eye;

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Optimizing PCR Protocols

References

References

Selected Reference(s)

Dionne L; Ward-Bailey P; Samples R; Bronson R; Johnson K. 2008. Ruby-eye 7 Jackson (ru-7J); a new remutation in the Hps6 gene MGI Direct Data Submission :.  [MGI Ref ID J:133644]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           A1

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Supply Details

Standard Supply

Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.

Supply Notes

Usually shipped between four and eight weeks of age. This strain is included in the Mouse Mutant Resource collection.

Control Information

	Control
	Heterozygote from the colony
Considerations for Choosing Controls
USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
International - Control Pricing Information for Genetically Engineered Mutant Strains.

General Terms and Conditions

See Terms of Use

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

---

Ordering and Purchasing Information

      Purchasing Information
      JAX^® Mice Orders
      Surgical Services

Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form

Terms of Use

Terms of Use

General Terms and Conditions

Contact information

General inquiries

Contracts Administration

phone:	207-288-6470
fax:	207-288-6655

JAX^® Mice & Services Conditions of Use

“Each recipient institution, including its employees and other researchers under its control (RECIPIENT), of mice or services using mice from The Jackson Laboratory (TJL) agrees that such mice, descendants of those mice derived by inbreeding or crossbreeding, including unmodified derivatives of those mice or their descendants (“MICE”) shall not be: (i) used for any purpose other than the internal research of the RECIPIENT, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services with respect to MICE. Acceptance of MICE from TJL shall be deemed agreement by RECIPIENT to these conditions, and departure from these conditions requires The Jackson Laboratory’s prior written authorization.”

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of MICE, products or services, The Jackson Laboratory will, at its option, provide credit or replacement for the MICE or product received or the services provided.

No Liability

In no event shall The Jackson Laboratory, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, products or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of The Jackson Laboratory, its agents or employees. In purchasing or receiving MICE, products or services from The Jackson Laboratory, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges The Jackson Laboratory from all such causes of action or damages, and further agrees to defend and indemnify The Jackson Laboratory from any costs or damages arising out of any third party claims.

MICE and biological materials are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to The Jackson Laboratory’s MICE, products and services. In addition, special terms and conditions of sale of certain MICE, products and services may be set forth separately in The Jackson Laboratory web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, products and services by The Jackson Laboratory, and by its licensees and distributors.

Acceptance of delivery of MICE, products or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on The Jackson Laboratory, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, products services by The Jackson Laboratory.